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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LILRB3 Gene

protein-coding   GIFtS: 55
GCID: GC19M054720

leukocyte immunoglobulin-like receptor, subfamily B (with...
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Aliases
for LILRB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 31 2
     CD85 Antigen-Like Family Member A2 3
ILT51 2 3 5     CD85a1
LIR31 2 3 5     CD85A2
LIR-31 2 3     LILRA62
HL91 2 5     PIRB2
Immunoglobulin-Like Transcript 52 3     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 32
Leukocyte Immunoglobulin-Like Receptor 32 3     Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 62
Monocyte Inhibitory Receptor HL92 3     CD85a Antigen3
ILT-52 3     

External Ids:    HGNC: 66071   Entrez Gene: 110252   Ensembl: ENSG000002045777   OMIM: 6048205   UniProtKB: O750223   

Export aliases for LILRB3 gene to outside databases

Previous GC identifers: GC19M055584 GC19M055145 GC19M059237 GC19M059412


Summaries
for LILRB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LILRB3:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at
chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or
four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor
tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I
molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune
response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit
autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune
receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting
phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity)

Gene Wiki entry for LILRB3


Genomic Views
for LILRB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_018930.1  NC_000019.9  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LILRB3 gene promoter:
         HOXA9B   E2F-4   E2F-3a   E2F-5   E2F-2   AREB6   E2F   E2F-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LILRB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for LILRB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054720:  view genomic region     (about GC identifiers)

Start:
 54,720,147 bp from pter      End:
 54,746,602 bp from pter
Size:
 26,456 bases      Orientation:
 minus strand

Proteins
for LILRB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor  
Size: 631 amino acids; 69386 Da
Subunit: Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Miscellaneous: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4
Secondary accessions: C9J1P3 C9JIP1 O15471 Q86U49
Alternative splicing: 3 isoforms:  O75022-1   O75022-2   O75022-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRB3: NX_O75022

Post-translational modifications:

  • Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with
    • PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75022

    • LILRB3 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001074919.1  NP_006855.2  

    ENSEMBL proteins: 
     ENSP00000375630   ENSP00000416920   ENSP00000345184   ENSP00000245620   ENSP00000388199  
     ENSP00000384274   ENSP00000412771  
    Reactome Protein details: O75022
    Human Recombinant Protein Products: 
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    Novus Biologicals LILRB3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LILRB3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9278324


    LILRB3 for ontologies           About GeneDecksing



    LILRB3 Antibody Products: 
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    Uscn Antibodies for LILRB3
    Search ThermoFisher Antibodies for LILRB3

    Assay Products for LILRB3: 
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    Uscn ELISAs and CLIAs for LILRB3

    Protein Domains /
    Families
    for LILRB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LILRB3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O75022

    ProtoNet protein and cluster: O75022

    1 Blocks protein family: IPB008262 Lipase

    UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
    Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the
    SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the
    downstream protein kinases SYK and BTK (By similarity)
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for LILRB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
    Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune
    receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting
    phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity)

         Genatlas biochemistry entry for LILRB3:
    leukocyte immunoglobulin-like receptor,subfamily B,member 3,expressed on dentritic cells,related to the Fc alpha
    receptor and natural killed inhibitory receptor superfamily

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    Inhib. RNA
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    OriGene shRNA RFP: LILRB3
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9382880
    GO:0004888transmembrane signaling receptor activity TAS9278324
    GO:0005515protein binding IPI18802077


    LILRB3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for LILRB3: Lilrb3tm1Stz Lilrb3tm1Ttk
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lilrb3):
     cellular  hematopoietic system  immune system  nervous system 

    LILRB3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LILRB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    3Osteoclast differentiation
    		Osteoclast differentiation1.00
    4Cleavage of Alpha-1-Microglobulin
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for LILRB3
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    2         Kegg Pathways  (Kegg details for LILRB3):
        Osteoclast differentiation
    B cell receptor signaling pathway


    LILRB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LILRB3

    5/9 Interacting proteins for LILRB3 (O750223) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235657P018923I2D: score=1 
    HLA-AP018923I2D: score=1 
    HCKP086313I2D: score=1 
    LYNP079483I2D: score=1 
    NR0B2Q154663I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS9382880
    GO:0007166cell surface receptor signaling pathway TAS9382880
    GO:0045671negative regulation of osteoclast differentiation IDA18802077


    LILRB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LILRB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LILRB3
    Search CenterWatch for drugs/clinical trials and news about LILRB3 / LIRB3 

    Transcripts
    for LILRB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LILRB3 gene (2 alternative transcripts): 
    NM_001081450.1  NM_006864.2  

    Unigene Cluster for LILRB3:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
    Hs.631592  [show with all ESTs]
    Unigene Representative Sequence: NM_001081450
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391750 ENST00000414379 ENST00000346401 ENST00000245620 ENST00000460208
    ENST00000469273 ENST00000436504 ENST00000468668 ENST00000445347 ENST00000407860
    ENST00000424807(uc002qee.1 uc002qef.1 uc002qeh.1 uc002qeg.1 uc010erh.1 uc002qej.1 uc002qep.1)


    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: LILRB3
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRB3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRB3

    Additional cDNA sequence: 

    AF000575.1 AF009632.1 AF009633.1 AF009635.1 AF009637.1 AF009638.1 AF009639.1 AF009641.1 
    AF009642.1 AF025533.1 AF031553.1 AF031554.1 AF031555.1 AF031556.1 AF344427.1 AF344432.1 
    AF344434.1 AF344435.1 AF344437.1 AK223265.1 AK290917.1 BC028153.1 BC104993.1 BC112198.1 
    EU814627.1 EU814628.1 EU915603.1 EU915604.1 EU915605.1 U91928.1 

    17 DOTS entries:

    DT.451144  DT.121487030  DT.121487233  DT.121487038  DT.121487675  DT.121487132  DT.121487666  DT.92466937 
    DT.121487270  DT.100778521  DT.92466963  DT.95370538  DT.101969502  DT.121487694  DT.97825698  DT.100033681 
    DT.121487411 

    14 AceView cDNA sequences:

    CD369952 BF903041 AI655471 BX280714 AF014924 AA770279 AK124026 AI678772 
    AV661443 AF014923 BI029427 NM_006864 NM_006865 NM_024318 

    GeneLoc Exon Structure


    Expression
    for LILRB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LILRB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCCCGGGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LILRB3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for LILRB3

    SOURCE GeneReport for Unigene cluster: Hs.631592

    UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
    Tissue specificity: Detected in monocytes and B-cells

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    In Situ
    Assay Products:     
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    Orthologs
    for LILRB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LILRB3 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    --
    (see all 59)    		 --
    		 31(a)
    24(a)
    (see all 59)    		 many ↔ many
    many ↔ many
    (see all 59)    		 Un(51843257-51844123)
    Un(59460063-59462402)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 26(a)
    21(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343329.1(823590-844642)
    GL343329.1(1231914-1234163)


    ENSEMBL Gene Tree for LILRB3 (if available)
    TreeFam Gene Tree for LILRB3 (if available) 

    Paralogs
    for LILRB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LILRB3 gene
    KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  LILRA52  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR2DL12  LILRB22  A1BG2  KIR2DL22  LILRA22  KIR3DL22  KIR2DL32  
    FCAR2  GP62  
    18/57 SIMAP similar genes for LILRB3 using alignment to 5 protein entries:     LIRB3_HUMAN (see all proteins) (see all similar genes):
    LILRA6    LILRB1    LILRA4    LILRA2    LILRA1    LILRA5
    LILRA3    LILRB5    LILRB2    KIR2DS    MIR cl-10    GP6
    p58    KIR2DS4    LILRB4    KIR-K36    KIR-G2    KIR-K64

    LILRB3 for paralogs           About GeneDecksing



    Genomic Variants
    for LILRB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 NCBI SNPs in LILRB3 are shown (see all 309)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1431415501,2
    		--54719766(+) ACCCCC/TGCGCC 2 -- ds50010--------
    rs1387899071,2
    		--54719767(+) CCCCCA/GCGCCT 2 -- ds50010--------
    rs2557751,2
    		C,--54719768(-) CAGGCA/GCGGGG 2 -- ds50017Minor allele frequency- G:0.13NA WA 132
    rs129719511,2
    		C,F,--54719858(+) TTCACT/CGGCTT 2 -- ds50015Minor allele frequency- C:0.25NA EA 246
    rs1842999141,2
    		--54719896(+) GGTCTC/TGTCCA 2 -- ds50010--------
    rs1469983741,2
    		--54720001(+) TACAGC/GTGTGT 2 -- ds50010--------
    rs1382031241,2
    		--54720017(+) CACGCC/TGGACT 2 -- ds50010--------
    rs1119133801,2
    		F--54720026(+) CTGGTC/TTTATT 2 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1866015721,2
    		--54720045(+) AGATGG/TGGCCT 2 -- ds50010--------
    rs1434631341,2
    		--54720058(+) CAATGC/TTGATC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LILRB3 (54720147 - 54746602 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 21 variations for LILRB3
         15/21 CNVs (see all 21): 30921 48058 35679 67610 61717 50207 78267 35677 37528 78268 4088 53265 73420 0520 89312

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    Disorders / Diseases
    for LILRB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LILRB3 for disorders           About MalaCards

    LILRB3 for disorders           About GeneDecksing

    OMIM gene information: 604820    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: LILRB3 (4 documents)

    Export disorders for LILRB3 gene to outside databases

    Publications
    for LILRB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LILRB3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with LILRB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PubMed id 9278324)1, 2, 3 Arm J.P.... Austen K.F. (1997)
    2. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)1, 2 Wende H.... Ziegler A. (2000)
    3. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2 Borges L....Cosman D. (1997)
    4. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. (PubMed id 9382880)1, 3 Colonna M....Lopez-Botet M. (1997)
    5. Leukocyte immunoglobulin-like receptors maintain uniq ue antigen-presenting properties of circulating myeloid dendritic cells in HIV- 1-infected elite controllers. (PubMed id 20631139)1 Huang J....Yu X.G. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    7. Allogeneic disparities in immunoglobulin-like transcr ipt 5 induce potent antibody responses in hematopoietic stem cell transplant re cipients. (PubMed id 19617579)1 Pfistershammer K....Steinberger P. (2009)
    8. Alternative mRNA splicing creates transcripts encodin g soluble proteins from most LILR genes. (PubMed id 19658091)1 Jones D.C....Young N.T. (2009)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. (PubMed id 18802077)1 Mori Y....Takai T. (2008)

    External Searches for LILRB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    NCBI Bookshelf
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    Genome Databases showing LILRB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11025 HGNC: 6607 AceView: LILRB3 Ensembl:ENSG00000204577 euGenes: HUgn11025
    ECgene: LILRB3 Kegg: 11025 H-InvDB: LILRB3

    Other Databases showing LILRB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LILRB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LILRB3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LILRB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LILRB3 gene:
    Search GeneIP for patents involving LILRB3

    GeneCards and IP:
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