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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LILRB3 Gene

protein-coding   GIFtS: 59
GCID: GC19M054720

Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 31 2
     CD85 Antigen-Like Family Member A2 3
ILT52 3 5     HL92 5
LIR32 3 5     CD85A2
Immunoglobulin-Like Transcript 52 3     LILRA62
Leukocyte Immunoglobulin-Like Receptor 32 3     PIRB2
Monocyte Inhibitory Receptor HL92 3     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 32
ILT-52 3     Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain),
Member 62
LIR-32 3     CD85a Antigen3

External Ids:    HGNC: 66071   Entrez Gene: 110252   Ensembl: ENSG000002045777   OMIM: 6048205   UniProtKB: O750223   

Export aliases for LILRB3 gene to outside databases

Previous GC identifers: GC19M055584 GC19M055145 GC19M059237 GC19M059412


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LILRB3 Gene:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster
at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which
contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic
immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds
to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation
of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune
response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for LILRB3 Gene: 
LILRB3 (leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3) is a protein-coding gene. Diseases associated with LILRB3 include hematopoietic stem cell transplantation, and type 1 diabetes, and among its related super-pathways are Immune System and BCR signaling pathway. GO annotations related to this gene include transmembrane signaling receptor activity and receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune
receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting
phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity)

Gene Wiki entry for LILRB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LILRB3 gene promoter:
         HOXA9B   E2F-4   E2F-3a   E2F-5   E2F-2   AREB6   E2F   E2F-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLILRB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for LILRB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054720:  view genomic region     (about GC identifiers)

Start:
54,720,147 bp from pter      End:
54,746,602 bp from pter
Size:
26,456 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr19-,NW_003571060 191,264-217,824      Chr19-,NW_003571057 191,260-195,631      Chr19-,NW_003571056 191,260-195,631     
Chr19-,NW_003571054 191,078-217,606      Chr19-,NW_003571061 191,260-217,849      Chr19-,NW_003571059 191,260-195,631     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor  
Size: 631 amino acids; 69386 Da
Subunit: Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Miscellaneous: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4
Secondary accessions: C9J1P3 C9JIP1 O15471 Q86U49
Alternative splicing: 3 isoforms:  O75022-1   O75022-2   O75022-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRB3: NX_O75022

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction
    with PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75022

  • LILRB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001074919.1  NP_006855.2  

    ENSEMBL proteins: 
     ENSP00000375630   ENSP00000416920   ENSP00000345184   ENSP00000245620   ENSP00000388199  
     ENSP00000384274   ENSP00000412771  
    Reactome Protein details: O75022
    Human Recombinant Protein Products for LILRB3: 
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    OriGene Protein Over-expression Lysate for LILRB3
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    Novus Biologicals LILRB3 Lysate
    Sino Biological Recombinant Protein for LILRB3
    Sino Biological Cell Lysate for LILRB3 
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    Cloud-Clone Corp. Proteins for LILRB3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9278324

    LILRB3 for ontologies           About GeneDecksing



    LILRB3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O75022

    ProtoNet protein and cluster: O75022

    1 Blocks protein domain: IPB008262 Lipase

    UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
    Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the
    dephosphorylation of the downstream protein kinases SYK and BTK (By similarity)
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    LILRB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRB3_HUMAN, O75022
    Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune
    receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting
    phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity)

         Genatlas biochemistry entry for LILRB3:
    leukocyte immunoglobulin-like receptor,subfamily B,member 3,expressed on dentritic cells,related to the Fc alpha
    receptor and natural killed inhibitory receptor superfamily

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9382880
    GO:0004888transmembrane signaling receptor activity TAS9278324
    GO:0005515protein binding IPI18802077
         
    LILRB3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lilrb3):
     cellular  hematopoietic system  immune system  nervous system 

    LILRB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LILRB3: Pirbtm1Stz Pirbtm1Ttk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LILRB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LILRB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LILRB3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LILRB3 

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LILRB3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    3Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
    4Spinal Cord Injury
    Spinal Cord Injury
    5Osteoclast differentiation
    Osteoclast differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LILRB3
        Spinal Cord Injury


    3        Reactome Pathways for LILRB3
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    2         Kegg Pathways  (Kegg details for LILRB3):
        Osteoclast differentiation
    B cell receptor signaling pathway


    LILRB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LILRB3

    5/9 Interacting proteins for LILRB3 (O750223) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235657P018923I2D: score=1 
    HLA-AP018923I2D: score=1 
    HCKP086313I2D: score=1 
    LYNP079483I2D: score=1 
    NR0B2Q154663I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS9382880
    GO:0007166cell surface receptor signaling pathway TAS9382880
    GO:0045671negative regulation of osteoclast differentiation IDA18802077

    LILRB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LILRB3 (LIRB3)

    Search CenterWatch for drugs/clinical trials and news about LILRB3 / LIRB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LILRB3 gene (2 alternative transcripts): 
    NM_001081450.1  NM_006864.2  

    Unigene Clusters for LILRB3:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
    Hs.631592  [show with all ESTs], Hs.688335  [show with all ESTs]
    Unigene Representative Sequences: NM_001081450, NM_024318
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391750 ENST00000414379 ENST00000346401 ENST00000245620 ENST00000460208
    ENST00000469273 ENST00000436504 ENST00000468668 ENST00000445347 ENST00000407860
    ENST00000424807(uc002qee.1 uc002qef.1 uc002qeh.1 uc002qeg.1 uc010erh.1 uc002qej.1 uc002qep.1)

    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRB3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRB3

    Additional mRNA sequence: 

    AF009632.1 AF031553.1 AF344428.1 AF344429.1 AF344430.1 AF344431.1 AF344432.1 AF344433.1 
    AF344434.1 AF344436.1 AF344437.1 AF344438.1 AF344439.1 AF344440.1 AF344441.1 AF344442.1 
    AF344443.1 AF344651.1 AF344652.1 AK124026.1 BC104993.1 BC112198.1 EU814627.1 U91928.1 

    20 DOTS entries:

    DT.121487233  DT.451144  DT.92466937  DT.121487270  DT.121487030  DT.121487038  DT.121487675  DT.121487132 
    DT.97825698  DT.121487666  DT.100778521  DT.121487694  DT.92466963  DT.101969502  DT.95370538  DT.121487411 
    DT.100033681  DT.100648231  DT.92466940  DT.95241439 

    14 AceView cDNA sequences:

    BX280714 AA770279 BF903041 BI029427 AV661443 AK124026 AF014923 CD369952 
    AI678772 AI655471 AF014924 NM_006864 NM_006865 NM_024318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LILRB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCCGGGAG
    LILRB3 Expression
    About this image


    Genevestigator expression for LILRB3

    SOURCE GeneReport for Unigene clusters: Hs.631592 Hs.688335

    UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
    Tissue specificity: Detected in monocytes and B-cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for LILRB3 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lilrb35
    Pira61
    leukocyte immunoglobulin-like receptor, subfamily B more5
    paired-Ig-like receptor A61
    66.82(n)1
    54.12(a)1
      7 (2.14 cM)5
    187291  NM_008848.11  NP_032874.11 
     37114095 


    ENSEMBL Gene Tree for LILRB3 (if available)
    TreeFam Gene Tree for LILRB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LILRB3 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  
    KIR3DL32  LILRA12  KIR3DS12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  LILRA22  
    KIR2DL32  FCAR2  GP62  
    18/60 SIMAP similar genes for LILRB3 using alignment to 5 protein entries:     LIRB3_HUMAN (see all proteins) (see all similar genes):
    LILRA6    LILRB1    LILRA4    LILRA2    LILRA1    LILRA5
    LILRA3    LILRB5    LILRB2    KIR2DS    MIR cl-10    GP6
    p58    KIR2DS4    KIR-K36    KIR-G2    KIR-K64    KIR-K78

    LILRB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/434 SNPs in LILRB3 are shown (see all 434)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0170064
    ----see VAR_0170062 W Q mis40--------
    VAR_0170074
    ----see VAR_0170072 Y R mis40--------
    VAR_0170094
    ----see VAR_0170092 Y F mis40--------
    VAR_0170024
    ----see VAR_0170022 R Q mis40--------
    VAR_0170084
    ----see VAR_0170082 Y H mis40--------
    VAR_0170044
    ----see VAR_0170042 E Q mis40--------
    VAR_0170104
    ----see VAR_0170102 H Y mis40--------
    VAR_0170054
    ----see VAR_0170052 S N mis40--------
    VAR_0170034
    ----see VAR_0170032 L W mis40--------
    rs1431415501,2
    --54719766(+) ACCCCC/TGCGCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LILRB3 (54720147 - 54746602 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/35 variations for LILRB3 (see all 35):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718859CNV Deletion23290073
    esv2718812CNV Deletion23290073
    esv2718860CNV Deletion23290073
    nsv2547CNV Insertion18451855
    nsv513760CNV Insertion21212237
    esv989644CNV Insertion20482838
    esv6034CNV Loss19470904
    nsv510774CNV Loss20534489
    dgv4003n71CNV Loss21882294
    nsv912405CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604820    OMIM disorders: --

    2 diseases for LILRB3:    About MalaCards
    hematopoietic stem cell transplantation    type 1 diabetes


    LILRB3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LILRB3
    Human Genome Epidemiology (HuGE) Navigator: LILRB3 (4 documents)

    Export disorders for LILRB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LILRB3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with LILRB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PubMed id 9278324)1, 2, 3 Arm J.P.... Austen K.F. (1997)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)1, 2 Wende H.... Ziegler A. (2000)
    4. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2 Borges L....Cosman D. (1997)
    5. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. (PubMed id 9382880)1, 3 Colonna M....Lopez-Botet M. (1997)
    6. Leukocyte immunoglobulin-like receptors maintain uniq ue antigen-presenting properties of circulating myeloid dendritic cells in HIV- 1-infected elite controllers. (PubMed id 20631139)1 Huang J....Yu X.G. (2010)
    7. Allogeneic disparities in immunoglobulin-like transcr ipt 5 induce potent antibody responses in hematopoietic stem cell transplant re cipients. (PubMed id 19617579)1 Pfistershammer K....Steinberger P. (2009)
    8. Alternative mRNA splicing creates transcripts encodin g soluble proteins from most LILR genes. (PubMed id 19658091)1 Jones D.C....Young N.T. (2009)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. (PubMed id 18802077)1 Mori Y....Takai T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11025 HGNC: 6607 AceView: LILRB3 Ensembl:ENSG00000204577 euGenes: HUgn11025
    ECgene: LILRB3 Kegg: 11025 H-InvDB: LILRB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LILRB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LILRB3 gene:
    Search GeneIP for patents involving LILRB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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