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LILRB3 Gene

protein-coding   GIFtS: 58
GCID: GC19M054720

Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 31 2
     CD85 Antigen-Like Family Member A2 3
ILT52 3 5     HL92 5
LIR32 3 5     CD85A2
Immunoglobulin-Like Transcript 52 3     LILRA62
Leukocyte Immunoglobulin-Like Receptor 32 3     PIRB2
Monocyte Inhibitory Receptor HL92 3     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 32
ILT-52 3     Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain),
Member 62
LIR-32 3     CD85a Antigen3

External Ids:    HGNC: 66071   Entrez Gene: 110252   Ensembl: ENSG000002045777   OMIM: 6048205   UniProtKB: O750223   

Export aliases for LILRB3 gene to outside databases

Previous GC identifers: GC19M055584 GC19M055145 GC19M059237 GC19M059412


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LILRB3 Gene:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster
at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which
contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic
immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds
to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation
of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune
response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for LILRB3 Gene:
LILRB3 (leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3) is a protein-coding gene. GO annotations related to this gene include transmembrane signaling receptor activity and receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune
receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting
phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity)

Gene Wiki entry for LILRB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NT_187693.1  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LILRB3 gene promoter:
         HOXA9B   E2F-4   E2F-3a   E2F-5   E2F-2   AREB6   E2F   E2F-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLILRB3 promoter sequence
   Search Chromatin IP Primers for LILRB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054720:  view genomic region     (about GC identifiers)

Start:
54,720,147 bp from pter      End:
54,746,602 bp from pter
Size:
26,456 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr19-,NW_003571054 191,078-217,606      Chr19-,NW_003571059 191,260-195,631      Chr19-,NW_003571057 191,260-195,631     
Chr19-,NW_003571061 191,260-217,849      Chr19-,NW_003571056 191,260-195,631      Chr19-,NW_003571058 191,260-195,631     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor  
Size: 631 amino acids; 69386 Da
Subunit: Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity)
Miscellaneous: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4
Secondary accessions: C9J1P3 C9JIP1 O15471 Q86U49
Alternative splicing: 3 isoforms:  O75022-1   O75022-2   O75022-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRB3: NX_O75022

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction
    with PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity)1
  • Glycosylation2 at Asn139, Asn280, Asn301, Asn340
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (2 alternative transcripts): 
    NP_001074919.2  NP_006855.3  

    ENSEMBL proteins: 
     ENSP00000375630   ENSP00000416920   ENSP00000345184   ENSP00000245620   ENSP00000388199  
     ENSP00000384274   ENSP00000412771  
    Reactome Protein details: O75022

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O75022

    ProtoNet protein and cluster: O75022

    1 Blocks protein domain: IPB008262 Lipase

    UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
    Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the
    dephosphorylation of the downstream protein kinases SYK and BTK (By similarity)
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with LILRB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRB3_HUMAN, O75022
    Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune
    receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting
    phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity)

         Genatlas biochemistry entry for LILRB3:
    leukocyte immunoglobulin-like receptor,subfamily B,member 3,expressed on dentritic cells,related to the Fc alpha
    receptor and natural killed inhibitory receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9382880
    GO:0004888transmembrane signaling receptor activity TAS9278324
    GO:0005515protein binding IPI18802077
         
    Find genes that share ontologies with LILRB3           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lilrb3):
     cellular  hematopoietic system  immune system  nervous system 

    Find genes that share phenotypes with LILRB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LILRB3: Pirbtm1Stz Pirbtm1Ttk

       genOway: Develop your customized and physiologically relevant rodent model for LILRB3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIRB3_HUMAN, O75022: Cell membrane; Single-pass type I membrane protein

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS9278324

    Find genes that share ontologies with LILRB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LILRB3 About    
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Spinal Cord Injury
    Spinal Cord Injury
    4Osteoclast differentiation
    Osteoclast differentiation
    5Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Find genes that share SuperPaths with LILRB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LILRB3
        Spinal Cord Injury


    1 Reactome Pathway for LILRB3
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    2 Kegg Pathways  (Kegg details for LILRB3):
        Osteoclast differentiation
    B cell receptor signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LILRB3
    Interactions:

        GeneGlobe Interaction Network for LILRB3

    Selected Interacting proteins for LILRB3 (O750223) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235657P018923I2D: score=1 
    HLA-AP018923I2D: score=1 
    HCKP086313I2D: score=1 
    LYNP079483I2D: score=1 
    NR0B2Q154663I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0006952defense response TAS9382880
    GO:0007166cell surface receptor signaling pathway TAS9382880
    GO:0045671negative regulation of osteoclast differentiation IDA18802077

    Find genes that share ontologies with LILRB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for LILRB3 (LIRB3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LILRB3 gene (2 alternative transcripts): 
    NM_001081450.2  NM_006864.3  

    Unigene Cluster for LILRB3:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
    Hs.631592  [show with all ESTs]
    Unigene Representative Sequence: NM_001081450
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391750 ENST00000414379 ENST00000346401 ENST00000245620 ENST00000460208
    ENST00000469273 ENST00000436504 ENST00000468668 ENST00000445347 ENST00000407860
    ENST00000424807(uc002qee.1 uc002qef.1 uc002qeh.1 uc002qeg.1 uc010erh.1 uc002qej.1 uc002qep.1)

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    Additional mRNA sequence: 

    AF000575.1 AF009633.1 AF009635.1 AF009637.1 AF009638.1 AF009639.1 AF009641.1 AF009642.1 
    AF025533.1 AF031554.1 AF031555.1 AF031556.1 AF344427.1 AF344435.1 AK223265.1 AK290917.1 
    BC028153.1 EU814628.1 EU915603.1 EU915604.1 EU915605.1 

    17 DOTS entries:

    DT.121487233  DT.451144  DT.121487030  DT.121487038  DT.121487675  DT.121487666  DT.92466937  DT.121487270 
    DT.121487132  DT.100778521  DT.92466963  DT.95370538  DT.101969502  DT.121487694  DT.97825698  DT.100033681 
    DT.121487411 

    14 AceView cDNA sequences:

    AF014923 AV661443 AI655471 BX280714 AK124026 AF014924 AA770279 AI678772 
    BF903041 BI029427 CD369952 NM_006864 NM_006865 NM_024318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LILRB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCCGGGAG
    LILRB3 Expression
    About this image


    LILRB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 12 entries
             Granulocytes Peripheral Blood
             Peripheral Blood Monocytes (PB CD14+)   
             neutrophils   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Umbilical Veins
             Cord Blood Monocytes (CD14+)   
     
     Liver (Hepatobiliary System)
    LILRB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.631592

    UniProtKB/Swiss-Prot: LIRB3_HUMAN, O75022
    Tissue specificity: Detected in monocytes and B-cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LILRB3 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lilrb35
    Pira61
    leukocyte immunoglobulin-like receptor, subfamily B more5
    paired-Ig-like receptor A61
    70.12(n)1
    57.78(a)1
      7 (2.14 cM)5
    187291  NM_008848.11  NP_032874.11 
     37114095 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    19(a)
    1 → many
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for LILRB3 (if available)
    TreeFam Gene Tree for LILRB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LILRB3 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  
    KIR3DL32  LILRA12  KIR3DS12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  LILRA22  
    KIR2DL32  FCAR2  GP62  
    Selected SIMAP similar genes for LILRB3 using alignment to 27 protein entries:     LIRB3_HUMAN (see all proteins) (see all similar genes):
    LILRA6    LILRB1    LILRA4    LILRA2    LILRA1    LILRA5
    LILRA3    LILRB5    LILRB2    KIR2DS    MIR cl-10    GP6
    p58    KIR2DS4    KIR-K36    KIR-G2    KIR-K64    KIR-K78

    Find genes that share paralogs with LILRB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LILRB3 (see all 434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    rs1431415501,2
    --54719766(+) ACCCCC/TGCGCC 2 -- ds50010--------
    rs1387899071,2
    --54719767(+) CCCCCA/GCGCCT 2 -- ds50010--------
    rs2557751,2
    C--54719768(-) caggcA/Gcgggg 2 -- ds50017Minor allele frequency- G:0.13NA WA 132
    rs129719511,2
    C,F--54719858(+) TTCACT/CGGCTT 2 -- ds50015Minor allele frequency- C:0.25NA EA 246
    rs1842999141,2
    --54719896(+) GGTCTC/TGTCCA 2 -- ds50010--------
    rs1469983741,2
    --54720001(+) TACAGC/GTGTGT 2 -- ds50010--------
    rs1382031241,2
    --54720017(+) CACGCC/TGGACT 2 -- ds50010--------
    rs1119133801,2
    F--54720026(+) CTGGTC/TTTATT 2 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1866015721,2
    --54720045(+) AGATGG/TGGCCT 2 -- ds50010--------
    rs1434631341,2
    C--54720058(+) CAATGC/TTGATC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LILRB3 (54720147 - 54746602 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LILRB3 (see all 35):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718859CNV Deletion23290073
    esv2718812CNV Deletion23290073
    esv2718860CNV Deletion23290073
    nsv2547CNV Insertion18451855
    nsv513760CNV Insertion21212237
    esv989644CNV Insertion20482838
    esv6034CNV Loss19470904
    nsv510774CNV Loss20534489
    dgv4003n71CNV Loss21882294
    nsv912405CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604820    OMIM disorders: --


    Find genes that share disorders with LILRB3           About GenesLikeMe

    Genetic Association Database (GAD): LILRB3
    Human Genome Epidemiology (HuGE) Navigator: LILRB3 (4 documents)

    Export disorders for LILRB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for LILRB3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with LILRB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PubMed id 9278324)1, 2, 3 Arm J.P.... Austen K.F. (J. Immunol. 1997)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)1, 2 Wende H.... Ziegler A. (Immunogenetics 2000)
    4. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2 Borges L.... Cosman D. (J. Immunol. 1997)
    5. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. (PubMed id 9382880)1, 3 Colonna M....LA^pez-Botet M. (J. Exp. Med. 1997)
    6. Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair. (PubMed id 24096970)1 Bashirova A.A....Carrington M. (Immunogenetics 2014)
    7. Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. (PubMed id 20631139)1 Huang J....Yu X.G. (J. Virol. 2010)
    8. Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients. (PubMed id 19617579)1 Pfistershammer K....Steinberger P. (Blood 2009)
    9. Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. (PubMed id 19658091)1 Jones D.C....Young N.T. (Eur. J. Immunol. 2009)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11025 HGNC: 6607 AceView: LILRB3 Ensembl:ENSG00000204577 euGenes: HUgn11025
    ECgene: LILRB3 Kegg: 11025 H-InvDB: LILRB3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LILRB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LILRB3 gene:
    Search GeneIP for patents involving LILRB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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