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Aliases for LILRB3 Gene

Aliases for LILRB3 Gene

  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 3 2 3
  • ILT5 3 4 6
  • LIR3 3 4 6
  • Leukocyte Immunoglobulin-Like Receptor 3 3 4
  • CD85 Antigen-Like Family Member A 3 4
  • Immunoglobulin-Like Transcript 5 3 4
  • Monocyte Inhibitory Receptor HL9 3 4
  • ILT-5 3 4
  • LIR-3 3 4
  • HL9 3 6
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 3
  • CD85a Antigen 4
  • LILRA6 3
  • CD85A 3
  • PIRB 3

External Ids for LILRB3 Gene

Previous GeneCards Identifiers for LILRB3 Gene

  • GC19M055584
  • GC19M055145
  • GC19M059237
  • GC19M059412
  • GC19M054720

Summaries for LILRB3 Gene

Entrez Gene Summary for LILRB3 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB3 Gene

LILRB3 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Spinal Cord Injury. GO annotations related to this gene include receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRB3 Gene

  • May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity).

Gene Wiki entry for LILRB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRB3 Gene

Genomics for LILRB3 Gene

Regulatory Elements for LILRB3 Gene

Genomic Location for LILRB3 Gene

54,216,278 bp from pter
54,223,506 bp from pter
7,229 bases
Minus strand

Genomic View for LILRB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LILRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB3 Gene

Proteins for LILRB3 Gene

  • Protein details for LILRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 3
    Protein Accession:
    Secondary Accessions:
    • C9J1P3
    • C9JIP1
    • O15471
    • Q86U49

    Protein attributes for LILRB3 Gene

    631 amino acids
    Molecular mass:
    69386 Da
    Quaternary structure:
    • Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2.
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4

    Alternative splice isoforms for LILRB3 Gene


neXtProt entry for LILRB3 Gene

Proteomics data for LILRB3 Gene at MOPED

Post-translational modifications for LILRB3 Gene

  • Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2 (By similarity).
  • Glycosylation at Asn139, Asn280, Asn301, and Asn340
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRB3 Gene

No data available for DME Specific Peptides for LILRB3 Gene

Domains for LILRB3 Gene

Gene Families for LILRB3 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • LILR :Leukocyte immunoglobulin-like receptors

Protein Domains for LILRB3 Gene

Suggested Antigen Peptide Sequences for LILRB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75022
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK (By similarity).
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRB3: view

Function for LILRB3 Gene

Molecular function for LILRB3 Gene

GENATLAS Biochemistry: leukocyte immunoglobulin-like receptor,subfamily B,member 3,expressed on dentritic cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
UniProtKB/Swiss-Prot Function: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity).

Gene Ontology (GO) - Molecular Function for LILRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9382880
GO:0004888 transmembrane signaling receptor activity TAS 9278324
GO:0005515 protein binding IPI 18802077
genes like me logo Genes that share ontologies with LILRB3: view
genes like me logo Genes that share phenotypes with LILRB3: view

Animal Models for LILRB3 Gene

MGI Knock Outs for LILRB3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LILRB3 Gene

Localization for LILRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB3 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for LILRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9278324
genes like me logo Genes that share ontologies with LILRB3: view

No data available for Subcellular locations from COMPARTMENTS for LILRB3 Gene

Pathways for LILRB3 Gene

genes like me logo Genes that share pathways with LILRB3: view

Pathways by source for LILRB3 Gene

Interacting Proteins for LILRB3 Gene

Selected Interacting proteins: O75022-LIRB3_HUMAN for LILRB3 Gene via I2D

Gene Ontology (GO) - Biological Process for LILRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006952 defense response TAS 9382880
GO:0007166 cell surface receptor signaling pathway TAS 9382880
GO:0045671 negative regulation of osteoclast differentiation IDA 18802077
genes like me logo Genes that share ontologies with LILRB3: view

Transcripts for LILRB3 Gene

mRNA/cDNA for LILRB3 Gene

Unigene Clusters for LILRB3 Gene

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB3 Gene

No ASD Table

Relevant External Links for LILRB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRB3 Gene

mRNA expression in normal human tissues for LILRB3 Gene

mRNA differential expression in normal tissues according to GTEx for LILRB3 Gene

This gene is overexpressed in Whole Blood (43.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LILRB3 Gene

SOURCE GeneReport for Unigene cluster for LILRB3 Gene Hs.631592

mRNA Expression by UniProt/SwissProt for LILRB3 Gene

Tissue specificity: Detected in monocytes and B-cells.
genes like me logo Genes that share expressions with LILRB3: view

Orthologs for LILRB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRB3 35
  • 95.19 (n)
  • 90.49 (a)
  • 90 (a)
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
-- 36
  • 41 (a)
-- 36
  • 42 (a)
-- 36
  • 52 (a)
-- 36
  • 66 (a)
-- 36
  • 49 (a)
-- 36
  • 50 (a)
-- 36
  • 44 (a)
-- 36
  • 52 (a)
-- 36
  • 59 (a)
  • 59 (a)
(Canis familiaris)
Mammalia -- 36
  • 58 (a)
-- 36
  • 61 (a)
  • 72.2 (n)
  • 58.8 (a)
(Mus musculus)
Mammalia Lilrb3 16
Lilrb4 36
  • 49 (a)
Pira6 35
  • 70.12 (n)
  • 57.78 (a)
(Rattus norvegicus)
Mammalia LOC683463 35
  • 68.7 (n)
  • 55.1 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 19 (a)
Species with no ortholog for LILRB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRB3 Gene

Gene Tree for LILRB3 (if available)
Gene Tree for LILRB3 (if available)

Paralogs for LILRB3 Gene

genes like me logo Genes that share paralogs with LILRB3: view

Variants for LILRB3 Gene

Sequence variations from dbSNP and Humsavar for LILRB3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs369824 -- 54,221,643(-) ACCTG(A/G)AAGGG intron-variant
rs409147 -- 54,224,619(-) ACCAA(C/T)GCCAG upstream-variant-2KB
rs438458 -- 54,224,751(-) ACCTG(A/G)CCTTT upstream-variant-2KB
rs582278 -- 54,224,791(-) TCATA(C/T)GGTTG upstream-variant-2KB
rs590151 -- 54,224,445(+) GGTGA(C/G)GCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LILRB3 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv4002n71 CNV Loss 21882294
nsv510774 CNV Loss 20534489
dgv1118e1 CNV Complex 17122850
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
nsv2546 CNV Loss 18451855
nsv458783 CNV Loss 19166990
essv101799 CNV Loss 18971310
dgv1120e1 CNV Complex 17122850
dgv1121e1 CNV Complex 17122850
dgv1122e1 CNV Complex 17122850
dgv432n27 CNV Loss 19166990
nsv912399 CNV Loss 21882294
nsv183 CNV Loss 15895083
nsv517129 CNV Gain+Loss 19592680
dgv4003n71 CNV Loss 21882294
nsv912402 CNV Gain 21882294
esv1003658 CNV Gain 20482838
nsv2547 CNV Insertion 18451855
nsv912403 CNV Gain 21882294
nsv912404 CNV Gain+Loss 21882294
nsv912405 CNV Loss 21882294
nsv9752 CNV Gain+Loss 18304495
esv2718859 CNV Deletion 23290073
esv6034 CNV Loss 19470904
esv989644 CNV Insertion 20482838
esv23225 CNV Gain+Loss 19812545
dgv598n67 CNV Gain 20364138
nsv514901 CNV Complex 21397061
dgv1123e1 CNV Complex 17122850
dgv1124e1 CNV Complex 17122850
dgv1125e1 CNV Complex 17122850
nsv513760 CNV Insertion 21212237
esv2718860 CNV Deletion 23290073

Relevant External Links for LILRB3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRB3 Gene

Disorders for LILRB3 Gene

Relevant External Links for LILRB3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LILRB3: view

No data available for UniProtKB/Swiss-Prot for LILRB3 Gene

Publications for LILRB3 Gene

  1. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PMID: 9278324) Arm J.P. … Austen K.F. (J. Immunol. 1997) 2 3 4
  2. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. (PMID: 9382880) Colonna M. … LA^pez-Botet M. (J. Exp. Med. 1997) 2 3
  3. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L. … Cosman D. (J. Immunol. 1997) 3 4
  4. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for LILRB3 Gene

  • antibodies-online proteins for LILRB3
  • antibodies-online antibodies for LILRB3
  • antibodies-online kits for LILRB3

Sources for LILRB3 Gene

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