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Aliases for LILRB2 Gene

Aliases for LILRB2 Gene

  • Leukocyte Immunoglobulin Like Receptor B2 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2 2 3
  • Monocyte/Macrophage Immunoglobulin-Like Receptor 10 3 4
  • CD85 Antigen-Like Family Member D 3 4
  • Myeloid Inhibitory Receptor 10 2 3
  • Leucocyte Ig-Like Receptor B2 2 3
  • MIR-10 3 4
  • ILT-4 3 4
  • LIR-2 3 4
  • MIR10 3 4
  • ILT4 3 4
  • LIR2 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 3
  • Leukocyte Immunoglobulin-Like Receptor 2 4
  • Immunoglobulin-Like Transcript 4 4
  • Ig-Like Transcript 4 3
  • CD85d Antigen 4
  • CD85D 3

External Ids for LILRB2 Gene

Previous GeneCards Identifiers for LILRB2 Gene

  • GC19M055583
  • GC19M055149
  • GC19M059454
  • GC19M059470
  • GC19M059469
  • GC19M054777
  • GC19M051105
  • GC19M054267
  • GC19M054281
  • GC19M054286
  • GC19M054289
  • GC19M054292

Summaries for LILRB2 Gene

Entrez Gene Summary for LILRB2 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB2 Gene

LILRB2 (Leukocyte Immunoglobulin Like Receptor B2) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include receptor activity and protein phosphatase 1 binding. An important paralog of this gene is LILRB1.

UniProtKB/Swiss-Prot for LILRB2 Gene

  • Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Wiki entry for LILRB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRB2 Gene

Genomics for LILRB2 Gene

Regulatory Elements for LILRB2 Gene

Enhancers for LILRB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G054318 1.3 FANTOM5 Ensembl ENCODE 18.9 -37.9 -37917 1.0 MTA2 RNF2 CEBPG TBX21 ATF2 ATF3 IKZF1 TARDBP EED NBN LILRB2 LILRB3 LAIR1 LILRA6 TTYH1 ENSG00000227407 LILRB5 ENSG00000249189 CNOT3 ENSG00000237017
GH19G054270 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +9.3 9284 2.2 ZNF777 ZNF316 PKNOX1 ZNF114 CUX1 NFE2 ZNF112 LAIR1 LILRB2 OSCAR MYADM LILRB3 LILRB1 LILRA5 VSTM1 LILRB4 NLRP12
GH19G054368 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -91.7 -91652 8.9 HDGF PKNOX1 YY1 ZNF766 ZNF143 JUNB REST TBX21 MAFF ATF4 FCAR LAIR1 LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1 LILRA2
GH19G054018 1.6 FANTOM5 Ensembl ENCODE 10.9 +260.1 260067 6.8 PKNOX1 FOXA2 ATF1 CREB3L1 ARID4B SIN3A TCF12 GTF3C2 ZNF302 GATA2 LILRB3 ZNF845 ZNF525 ENSG00000235681 ENSG00000267265 LENG8-AS1 ZNF765 PRPF31 VSTM1 LILRA5
GH19G054660 1.6 FANTOM5 Ensembl ENCODE 10.5 -381.1 -381113 4.2 HDGF ATF1 PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A GLI4 GLIS2 FOS LILRB4 FCAR LAIR1 LILRB1 KIR3DX1 LILRB2 KIR2DL3 LILRA5 LILRB3 LILRA1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LILRB2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LILRB2 gene promoter:

Genomic Location for LILRB2 Gene

Chromosome:
19
Start:
54,273,812 bp from pter
End:
54,281,184 bp from pter
Size:
7,373 bases
Orientation:
Minus strand

Genomic View for LILRB2 Gene

Genes around LILRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB2 Gene

Proteins for LILRB2 Gene

  • Protein details for LILRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N423-LIRB2_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 2
    Protein Accession:
    Q8N423
    Secondary Accessions:
    • A8MU67
    • C9JF29
    • O75017
    • Q8NHJ7
    • Q8NHJ8

    Protein attributes for LILRB2 Gene

    Size:
    598 amino acids
    Molecular mass:
    65039 Da
    Quaternary structure:
    • Binds PTPN6 when phosphorylated. Binds FCGR1A.

    Three dimensional structures from OCA and Proteopedia for LILRB2 Gene

    Alternative splice isoforms for LILRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRB2 Gene

Post-translational modifications for LILRB2 Gene

  • Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
  • Glycosylation at posLast=280280, isoforms=2, 3, 4301, and isoforms=2, 3, 4340
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for LILRB2 (LILRB2/CD85d/ILT4)
  • Cloud-Clone Corp. Antibodies for LILRB2

No data available for DME Specific Peptides for LILRB2 Gene

Domains & Families for LILRB2 Gene

Protein Domains for LILRB2 Gene

Suggested Antigen Peptide Sequences for LILRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N423

UniProtKB/Swiss-Prot:

LIRB2_HUMAN :
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
genes like me logo Genes that share domains with LILRB2: view

Function for LILRB2 Gene

Molecular function for LILRB2 Gene

GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily B,member 2,expressed on monocytes,B cells,dentritic and natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,binding to MHC class I molecules A2,B44
UniProtKB/Swiss-Prot Function:
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Ontology (GO) - Molecular Function for LILRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9382880
GO:0005515 protein binding IPI 18802077
GO:0008157 protein phosphatase 1 binding IPI 9842885
GO:0023029 MHC class Ib protein binding IPI 20008523
GO:0032396 inhibitory MHC class I receptor activity IMP 14971032
genes like me logo Genes that share ontologies with LILRB2: view
genes like me logo Genes that share phenotypes with LILRB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LILRB2 (LILRB2/CD85d/ILT4)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRB2 Gene

Localization for LILRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRB2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LILRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 14971032
GO:0005737 cytoplasm IDA 19124746
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IC 14971032
GO:0009986 cell surface IDA 14971032
genes like me logo Genes that share ontologies with LILRB2: view

Pathways & Interactions for LILRB2 Gene

genes like me logo Genes that share pathways with LILRB2: view

Pathways by source for LILRB2 Gene

Interacting Proteins for LILRB2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000375629%0d%0a9606.ENSP00000452780%0d%0a9606.ENSP00000365817%0d%0a9606.ENSP00000353472%0d%0a9606.ENSP00000351497%0d%0a9606.ENSP00000356946%0d%0a
Selected Interacting proteins: ENSP00000375629 Q8N423-LIRB2_HUMAN for LILRB2 Gene via STRING IID UniProtKB

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
ANGPTL2
ANGPTL5

Gene Ontology (GO) - Biological Process for LILRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002578 negative regulation of antigen processing and presentation IDA 19124746
GO:0002645 positive regulation of tolerance induction IMP 22802125
GO:0002666 positive regulation of T cell tolerance induction IMP 20008523
genes like me logo Genes that share ontologies with LILRB2: view

No data available for SIGNOR curated interactions for LILRB2 Gene

Drugs & Compounds for LILRB2 Gene

(2) Drugs for LILRB2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with LILRB2: view

Transcripts for LILRB2 Gene

Unigene Clusters for LILRB2 Gene

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LILRB2 (LILRB2/CD85d/ILT4)

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3:

Relevant External Links for LILRB2 Gene

GeneLoc Exon Structure for
LILRB2
ECgene alternative splicing isoforms for
LILRB2

Expression for LILRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRB2 Gene

This gene is overexpressed in Whole Blood (x31.6) and Spleen (x8.4).

Protein differential expression in normal tissues from HIPED for LILRB2 Gene

This gene is overexpressed in Monocytes (27.3), Cervix (19.5), and Neutrophil (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRB2 Gene



Protein tissue co-expression partners for LILRB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LILRB2 Gene:

LILRB2

SOURCE GeneReport for Unigene cluster for LILRB2 Gene:

Hs.655652

mRNA Expression by UniProt/SwissProt for LILRB2 Gene:

Q8N423-LIRB2_HUMAN
Tissue specificity: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.

Evidence on tissue expression from TISSUES for LILRB2 Gene

  • Blood(4.6)
  • Spleen(4.6)
  • Lymph node(4.5)
genes like me logo Genes that share expression patterns with LILRB2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRB2 Gene

Orthologs for LILRB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRB2 35
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC484306 34
  • 72.89 (n)
-- 35
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pirb 35
  • 33 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia KIR2DL5A 35
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 20 (a)
OneToMany
Species where no ortholog for LILRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRB2 Gene

ENSEMBL:
Gene Tree for LILRB2 (if available)
TreeFam:
Gene Tree for LILRB2 (if available)

Paralogs for LILRB2 Gene

Variants for LILRB2 Gene

Sequence variations from dbSNP and Humsavar for LILRB2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1128646 --
rs138253074 -- 54,273,858(+) TTTTC(A/T)CACAC nc-transcript-variant, utr-variant-3-prime
rs145755382 -- 54,273,857(+) TTTTT(C/T)ACACA nc-transcript-variant, utr-variant-3-prime
rs373032 --
rs383369 --

Structural Variations from Database of Genomic Variants (DGV) for LILRB2 Gene

Variant ID Type Subtype PubMed ID
dgv1074e212 CNV gain 25503493
dgv3654n100 CNV gain 25217958
dgv3657n100 CNV gain 25217958
dgv3660n100 CNV gain 25217958
dgv3661n100 CNV gain+loss 25217958
dgv3662n100 CNV gain 25217958
dgv6549n54 CNV gain 21841781
esv2718812 CNV deletion 23290073
esv2718860 CNV deletion 23290073
esv2718863 CNV deletion 23290073
esv2718864 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv2763032 CNV gain+loss 21179565
esv3574853 CNV gain 25503493
esv3644790 CNV loss 21293372
esv3644791 CNV gain 21293372
esv3644792 CNV loss 21293372
esv3644793 CNV gain 21293372
nsv1148744 OTHER inversion 26484159
nsv428371 CNV gain+loss 18775914
nsv435704 CNV deletion 17901297
nsv528370 CNV loss 19592680
nsv580193 CNV gain 21841781
nsv833878 CNV loss 17160897
nsv963078 CNV duplication 23825009
nsv9753 CNV loss 18304495

Variation tolerance for LILRB2 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.32; 94.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRB2 Gene

Disorders for LILRB2 Gene

Relevant External Links for LILRB2

Genetic Association Database (GAD)
LILRB2
Human Genome Epidemiology (HuGE) Navigator
LILRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRB2

No disorders were found for LILRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRB2 Gene

Publications for LILRB2 Gene

  1. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. (PMID: 12853576) Shiroishi M. … Maenaka K. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 22 64
  2. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. (PMID: 11875462) Chang C.C. … Suciu-Foca N. (Nat. Immunol. 2002) 3 4 22 64
  3. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor- mediated signaling in monocytes. (PMID: 9842885) Fanger N.A. … Borges L. (Eur. J. Immunol. 1998) 3 4 22 64
  4. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 46 64
  5. Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction. (PMID: 19124746) Li D. … Xu X.N. (J. Immunol. 2009) 3 22 64

Products for LILRB2 Gene

Sources for LILRB2 Gene

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