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Aliases for LILRB2 Gene

Aliases for LILRB2 Gene

  • Leukocyte Immunoglobulin Like Receptor B2 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2 2 3 5
  • Monocyte/Macrophage Immunoglobulin-Like Receptor 10 3 4
  • CD85 Antigen-Like Family Member D 3 4
  • Myeloid Inhibitory Receptor 10 2 3
  • Leucocyte Ig-Like Receptor B2 2 3
  • MIR-10 3 4
  • ILT-4 3 4
  • LIR-2 3 4
  • MIR10 3 4
  • ILT4 3 4
  • LIR2 3 4
  • Leukocyte Immunoglobulin-Like Receptor 2 4
  • Immunoglobulin-Like Transcript 4 4
  • Ig-Like Transcript 4 3
  • CD85d Antigen 4
  • CD85D 3

External Ids for LILRB2 Gene

Previous GeneCards Identifiers for LILRB2 Gene

  • GC19M055583
  • GC19M055149
  • GC19M059454
  • GC19M059470
  • GC19M059469
  • GC19M054777
  • GC19M051105
  • GC19M054267
  • GC19M054281

Summaries for LILRB2 Gene

Entrez Gene Summary for LILRB2 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB2 Gene

LILRB2 (Leukocyte Immunoglobulin Like Receptor B2) is a Protein Coding gene. Among its related pathways are Immune System and Osteoclast differentiation. GO annotations related to this gene include receptor activity and protein phosphatase 1 binding. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRB2 Gene

  • Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Wiki entry for LILRB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRB2 Gene

Genomics for LILRB2 Gene

Regulatory Elements for LILRB2 Gene

Promoters for LILRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LILRB2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LILRB2 gene promoter:

Genomic Location for LILRB2 Gene

Chromosome:
19
Start:
54,238,904 bp from pter
End:
54,281,184 bp from pter
Size:
42,281 bases
Orientation:
Minus strand

Genomic View for LILRB2 Gene

Genes around LILRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB2 Gene

Proteins for LILRB2 Gene

  • Protein details for LILRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N423-LIRB2_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 2
    Protein Accession:
    Q8N423
    Secondary Accessions:
    • A8MU67
    • C9JF29
    • O75017
    • Q8NHJ7
    • Q8NHJ8

    Protein attributes for LILRB2 Gene

    Size:
    598 amino acids
    Molecular mass:
    65039 Da
    Quaternary structure:
    • Binds PTPN6 when phosphorylated. Binds FCGR1A.

    Three dimensional structures from OCA and Proteopedia for LILRB2 Gene

    Alternative splice isoforms for LILRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRB2 Gene

Proteomics data for LILRB2 Gene at MOPED

Post-translational modifications for LILRB2 Gene

  • Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
  • Glycosylation at Asn 280, Asn 301, and Asn 340
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for LILRB2 (LILRB2/CD85d/ILT4)

No data available for DME Specific Peptides for LILRB2 Gene

Domains & Families for LILRB2 Gene

Protein Domains for LILRB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LILRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N423

UniProtKB/Swiss-Prot:

LIRB2_HUMAN :
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRB2: view

Function for LILRB2 Gene

Molecular function for LILRB2 Gene

GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily B,member 2,expressed on monocytes,B cells,dentritic and natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,binding to MHC class I molecules A2,B44
UniProtKB/Swiss-Prot Function:
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Ontology (GO) - Molecular Function for LILRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 18802077
GO:0023029 MHC class Ib protein binding IPI 20008523
genes like me logo Genes that share ontologies with LILRB2: view
genes like me logo Genes that share phenotypes with LILRB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRB2 Gene

Localization for LILRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LILRB2 Gene COMPARTMENTS Subcellular localization image for LILRB2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LILRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9079806
genes like me logo Genes that share ontologies with LILRB2: view

Pathways & Interactions for LILRB2 Gene

genes like me logo Genes that share pathways with LILRB2: view

Pathways by source for LILRB2 Gene

Gene Ontology (GO) - Biological Process for LILRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006955 immune response TAS 9079806
GO:0007165 signal transduction IMP 20008523
GO:0007267 cell-cell signaling TAS 9382880
GO:0032755 positive regulation of interleukin-6 production NAS 18550825
genes like me logo Genes that share ontologies with LILRB2: view

No data available for SIGNOR curated interactions for LILRB2 Gene

Drugs & Compounds for LILRB2 Gene

(2) Drugs for LILRB2 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with LILRB2: view

Transcripts for LILRB2 Gene

mRNA/cDNA for LILRB2 Gene

(48) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRB2 Gene

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3:

Relevant External Links for LILRB2 Gene

GeneLoc Exon Structure for
LILRB2
ECgene alternative splicing isoforms for
LILRB2

Expression for LILRB2 Gene

mRNA expression in normal human tissues for LILRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRB2 Gene

This gene is overexpressed in Whole Blood (x31.6) and Spleen (x8.4).

Protein differential expression in normal tissues from HIPED for LILRB2 Gene

This gene is overexpressed in Monocytes (27.3), Cervix (19.5), and Neutrophil (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRB2 Gene



SOURCE GeneReport for Unigene cluster for LILRB2 Gene Hs.655652

mRNA Expression by UniProt/SwissProt for LILRB2 Gene

Q8N423-LIRB2_HUMAN
Tissue specificity: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.
genes like me logo Genes that share expression patterns with LILRB2: view

Protein tissue co-expression partners for LILRB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LILRB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC484306 35
  • 72.89 (n)
  • 58.8 (a)
-- 36
  • 51 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia KIR2DL5A 36
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pirb 36
  • 33 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LILRB2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
OneToMany
Species with no ortholog for LILRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRB2 Gene

ENSEMBL:
Gene Tree for LILRB2 (if available)
TreeFam:
Gene Tree for LILRB2 (if available)

Paralogs for LILRB2 Gene

genes like me logo Genes that share paralogs with LILRB2: view

Variants for LILRB2 Gene

Sequence variations from dbSNP and Humsavar for LILRB2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_016997 -
VAR_016998 -
VAR_016999 -
VAR_017000 -
VAR_047432 -

Structural Variations from Database of Genomic Variants (DGV) for LILRB2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv1118e1 CNV Complex 17122850
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
dgv1121e1 CNV Complex 17122850
dgv4003n71 CNV Loss 21882294
nsv912402 CNV Gain 21882294
dgv1125e1 CNV Complex 17122850
esv2718860 CNV Deletion 23290073
dgv4004n71 CNV Loss 21882294
nsv528370 CNV Loss 19592680
nsv435704 CNV Deletion 17901297
esv2718863 CNV Deletion 23290073
nsv912408 CNV Gain 21882294
nsv833878 CNV Loss 17160897
nsv9753 CNV Loss 18304495
nsv912409 CNV Gain 21882294
esv2718864 CNV Deletion 23290073

Variation tolerance for LILRB2 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.32; 94.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRB2 Gene

HapMap Linkage Disequilibrium report
LILRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRB2 Gene

Disorders for LILRB2 Gene

Relevant External Links for LILRB2

Genetic Association Database (GAD)
LILRB2
Human Genome Epidemiology (HuGE) Navigator
LILRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRB2

No disorders were found for LILRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRB2 Gene

Publications for LILRB2 Gene

  1. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. (PMID: 12853576) Shiroishi M. … Maenaka K. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23 67
  2. Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction. (PMID: 19124746) Li D. … Xu X.N. (J. Immunol. 2009) 3 23
  3. Crystallization and preliminary X-ray analysis of the low-affinity complex between human leukocyte antigen-G (HLA-G) and leukocyte Ig-like receptor B2 (LILRB2). (PMID: 19356145) Shiroishi M. … Maenaka K. (Protein Pept. Lett. 2009) 3 23
  4. Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells. (PMID: 19535644) Brenk M. … von Bubnoff D. (J. Immunol. 2009) 3 23
  5. HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses. (PMID: 20008523) Huang J. … Yu X.G. (J. Exp. Med. 2009) 3 23

Products for LILRB2 Gene

Sources for LILRB2 Gene

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