Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LILRB2 Gene

protein-coding   GIFtS: 61
GCID: GC19M054777

Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 21 2
     CD85 Antigen-Like Family Member D2 3
ILT42 3 5     CD85D2
LIR22 3 5     Ig-Like Transcript 42
MIR102 3 5     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 22
Monocyte/Macrophage Immunoglobulin-Like Receptor 102 3     CD85d Antigen3
ILT-42 3     Immunoglobulin-Like Transcript 43
LIR-22 3     Leukocyte Immunoglobulin-Like Receptor 23
MIR-102 3     

External Ids:    HGNC: 66061   Entrez Gene: 102882   Ensembl: ENSG000001310427   OMIM: 6048155   UniProtKB: Q8N4233   

Export aliases for LILRB2 gene to outside databases

Previous GC identifers: GC19M055583 GC19M055149 GC19M059454 GC19M059470 GC19M059469 GC19M051105


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LILRB2 Gene:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster
at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which
contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic
immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds
to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation
of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune
response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for LILRB2 Gene:
LILRB2 (leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2) is a protein-coding gene. Diseases associated with LILRB2 include herpes simplex, and chronic lymphocytic leukemia. GO annotations related to this gene include MHC class I protein binding and receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423
Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for
binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization
of intracellular calcium ions

Gene Wiki entry for LILRB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NT_187693.1  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LILRB2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLILRB2 promoter sequence
   Search Chromatin IP Primers for LILRB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054777:  view genomic region     (about GC identifiers)

Start:
54,777,675 bp from pter      End:
54,785,039 bp from pter
Size:
7,365 bases      Orientation:
minus strand

3 alternative locations:
Chr19-,NW_003571054 248,562-255,917      Chr19-,NW_003571060 248,805-253,362      Chr19-,NW_003571061 248,816-256,171     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 2 precursor  
Size: 598 amino acids; 65039 Da
Subunit: Binds PTPN6 when phosphorylated. Binds FCGR1A
3 PDB 3D structures from and Proteopedia for LILRB2:
2DYP (3D)        2GW5 (3D)        4LLA (3D)    
Secondary accessions: O75017 Q8NHJ7 Q8NHJ8
Alternative splicing: 2 isoforms:  Q8N423-1   Q8N423-2   (Alternative use of an acceptor site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRB2: NX_Q8N423

Explore proteomics data for LILRB2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues. Dephosphorylated by PTPN61
  • Glycosylation2 at Asn280, Asn301, Asn340
  • Modification sites at PhosphoSitePlus

  • See LILRB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001074447.1  NP_001265332.1  NP_001265333.1  NP_001265334.1  NP_001265335.1  NP_005865.2  

    ENSEMBL proteins: 
     ENSP00000375628   ENSP00000319960   ENSP00000394130   ENSP00000375626   ENSP00000375629  
     ENSP00000410117  
    Reactome Protein details: Q8N423

    LILRB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LILRB2 (ILT4/CD85d)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for LILRB2
    OriGene Protein Over-expression Lysate for LILRB2
    OriGene MassSpec for LILRB2
    OriGene Custom Protein Services for LILRB2
    GenScript Custom Purified and Recombinant Proteins Services for LILRB2
    Novus Biologicals LILRB2 Proteins
    Novus Biologicals LILRB2 Lysates
    Sino Biological Recombinant Protein for LILRB2
    Sino Biological Cell Lysate for LILRB2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LILRB2

    LILRB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LILRB2 (ILT4/CD85d)
    OriGene Antibodies for LILRB2
    OriGene Custom Antibody Services for LILRB2
    Novus Biologicals LILRB2 Antibodies
    Abcam antibodies for LILRB2
    Cloud-Clone Corp. Antibodies for LILRB2
    Search ThermoFisher Antibodies for LILRB2
    LSBio Antibodies in human, mouse, rat for LILRB2

    LILRB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LILRB2
    R&D Systems Proteome Profiler Antibody Arrays for LILRB2 (ILT4/CD85d)
    GenScript Custom Assay Services for LILRB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LILRB2
    Cloud-Clone Corp. CLIAs for LILRB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8N423

    ProtoNet protein and cluster: Q8N423

    UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423
    Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    LILRB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRB2_HUMAN, Q8N423
    Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
    Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for
    binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization
    of intracellular calcium ions

         Genatlas biochemistry entry for LILRB2:
    leukocyte immunoglobulin-like receptor,subfamily B,member 2,expressed on monocytes,B cells,dentritic and natural
    killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,binding to MHC
    class I molecules A2,B44

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9382880
    GO:0005515protein binding IPI18802077
    GO:0008157protein phosphatase 1 binding IPI9842885
    GO:0023029MHC class Ib protein binding IPI--
    GO:0032396inhibitory MHC class I receptor activity IMP14971032
         
    LILRB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LILRB2:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LILRB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LILRB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LILRB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LILRB2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LILRB2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LILRB2
    SwitchGear 3'UTR luciferase reporter plasmidLILRB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LILRB2
    Predesigned siRNA for gene silencing in human, mouse, rat LILRB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LILRB2

    Clone
    Products:
         
    OriGene clones in human, mouse for LILRB2 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LILRB2 (NM_001080978)
    Sino Biological Human cDNA Clone for LILRB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LILRB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LILRB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for LILRB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LIRB2_HUMAN, Q8N423: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane3
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA14971032
    GO:0005737cytoplasm IDA19124746
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IC14971032
    GO:0009986cell surface IDA14971032

    LILRB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LILRB2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Osteoclast differentiation
    Osteoclast differentiation
    3Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for LILRB2
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    1 Kegg Pathway  (Kegg details for LILRB2):
        Osteoclast differentiation


    LILRB2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LILRB2
    Interactions:

        GeneGlobe Interaction Network for LILRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for LILRB2 (Q8N4233 ENSP000003756294) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000230413P176933, ENSP000003835064I2D: score=2 STRING: ENSP00000383506
    ENSG00000235346P176933, ENSP000003973314I2D: score=2 STRING: ENSP00000397331
    HLA-GP176933, ENSP000003534724I2D: score=2 STRING: ENSP00000353472
    ENSG00000206506P176933I2D: score=2 
    ENSG00000233095P176933I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002578negative regulation of antigen processing and presentation IDA19124746
    GO:0002666positive regulation of T cell tolerance induction IMP--
    GO:0002767immune response-inhibiting cell surface receptor signaling pathway IMP14971032
    GO:0002774Fc receptor mediated inhibitory signaling pathway IDA9842885
    GO:0006955immune response TAS9079806

    LILRB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LILRB2 (LIRB2)

    1 HMDB Compound for LILRB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for LILRB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 2.38 4 10399074 (1), 9842885 (1), 12853576 (1)



    LILRB2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LILRB2 gene (6 alternative transcripts): 
    NM_001080978.2  NM_001278403.1  NM_001278404.1  NM_001278405.1  NM_001278406.1  NM_005874.3  

    Unigene Cluster for LILRB2:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
    Hs.655652  [show with all ESTs]
    Unigene Representative Sequence: NM_005874
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391748(uc010eri.3 uc010erj.3 uc002qfb.3 uc002qfc.3 uc010yet.2)
    ENST00000314446 ENST00000455108 ENST00000391746 ENST00000493242 ENST00000391749(uc010yeu.1)
    ENST00000471216 ENST00000434421
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LILRB2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LILRB2
    SwitchGear 3'UTR luciferase reporter plasmidLILRB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LILRB2
    Predesigned siRNA for gene silencing in human, mouse, rat LILRB2
    Clone
    Products:
         
    OriGene clones in human, mouse for LILRB2 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LILRB2 (NM_001080978)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LILRB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LILRB2
    OriGene qSTAR qPCR primer pairs in human, mouse for LILRB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LILRB2
      QuantiTect SYBR Green Assays in human, mouse, rat LILRB2
      QuantiFast Probe-based Assays in human, mouse, rat LILRB2

    Additional mRNA sequence: 

    AF000574.1 AF004231.2 AF011565.1 AF025528.1 AF283986.1 AF283987.1 AK226015.1 AK297041.1 
    AK297071.1 AK298649.1 AK310263.1 BC036827.1 DQ655938.2 EU915606.1 

    11 DOTS entries:

    DT.75189743  DT.121487035  DT.121487097  DT.102820252  DT.121487655  DT.92466952  DT.92466967  DT.99928022 
    DT.100814430  DT.100814431  DT.121487522 

    4 AceView cDNA sequences:

    AF283987 AA559048 AW193552 NM_005874 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LILRB2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -                                                         
    SP2:                                                                              
    SP3:                                                                              


    ECgene alternative splicing isoforms for LILRB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LILRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGATGCT
    LILRB2 Expression
    About this image


    LILRB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Spleen (Hematopoietic System)
    LILRB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LILRB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655652

    UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423
    Tissue specificity: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low
    levels in natural killer (NK) cells

        Custom PCR Arrays for LILRB2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LILRB2
    OriGene qSTAR qPCR primer pairs in human, mouse for LILRB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LILRB2
    QuantiTect SYBR Green Assays in human, mouse, rat LILRB2
    QuantiFast Probe-based Assays in human, mouse, rat LILRB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for LILRB2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    20(a)
    1 → many
    GL343329.1(823590-844642)
            Species with no ortholog for LILRB2

    ENSEMBL Gene Tree for LILRB2 (if available)
    TreeFam Gene Tree for LILRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LILRB2 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  
    KIR3DL32  LILRA12  KIR3DS12  KIR2DL12  A1BG2  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for LILRB2 using alignment to 4 protein entries:     LIRB2_HUMAN (see all proteins) (see all similar genes):
    MIR cl-10    LILRA1    LILRA3    LILRB1    LILRA2    LILRB5
    LILRA6    p58    LILRB3    LILRA4    KIR-K36    KIR-K64
    KIR412    LILRB4    KIR-K15    KIR-K3    KIR-K39    KIR-K65

    LILRB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LILRB2 (see all 429)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495676751,2
    C--54777207(+) AAAAAA/GTCCTA 2 -- ds50010--------
    rs1442109681,2
    --54777314(+) GGGGGG/TTTGTT 2 -- ds50010--------
    rs1487457081,2
    C--54777345(+) CCTCCC/TGGGTT 2 -- ds50010--------
    rs1873259241,2
    --54777379(+) TGCCTC/TCCAAG 2 -- ds50010--------
    rs104060311,2
    C,F,H--54777387(+) aagtaG/Actggg 2 -- ds50013Minor allele frequency- A:0.01NS NA 386
    rs1904711591,2
    C--54777431(+) TTGTAC/TTTTTA 2 -- ds50010--------
    rs1474822521,2
    C--54777677(+) TGATAC/TGATGG 2 -- ut310--------
    rs558496511,2
    C--54777711(+) ACACA-/CATATAT 2 -- ut311Minor allele frequency- CA:0.00NA 2
    rs754953981,2
    C--54777737(+) ACACAC/TACATA 2 -- ut310--------
    rs3737195681,2
    C--54777739(+) ACACAC/TATATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LILRB2 (54777675 - 54785039 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LILRB2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718864CNV Deletion23290073
    esv2718812CNV Deletion23290073
    nsv435704CNV Deletion17901297
    esv2718863CNV Deletion23290073
    esv2718860CNV Deletion23290073
    nsv9753CNV Loss18304495
    nsv528370CNV Loss19592680
    dgv4004n71CNV Loss21882294
    dgv4003n71CNV Loss21882294
    nsv833878CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LILRB2
    DNA2.0 Custom Variant and Variant Library Synthesis for LILRB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604815    OMIM disorders: --

    5 diseases for LILRB2:    
    About MalaCards
    herpes simplex    chronic lymphocytic leukemia    hiv-1    endotheliitis
    leukemia


    LILRB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LILRB2
    Human Genome Epidemiology (HuGE) Navigator: LILRB2 (1 document)

    Export disorders for LILRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LILRB2 gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with LILRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. (PubMed id 12853576)1, 2, 9 Shiroishi M.... Maenaka K. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. (PubMed id 11875462)1, 2, 9 Chang C.C....Suciu-Foca N. (Nat. Immunol. 2002)
    3. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor- mediated signaling in monocytes. (PubMed id 9842885)1, 2, 9 Fanger N.A....Borges L. (Eur. J. Immunol. 1998)
    4. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18. (PubMed id 12390682)1, 2 Willcox B.E....Bjorkman P.J. (BMC Struct. Biol. 2002)
    7. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2 Borges L.... Cosman D. (J. Immunol. 1997)
    8. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. (PubMed id 9079806)1, 3 Samaridis J. and Colonna M. (Eur. J. Immunol. 1997)
    9. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. (PubMed id 9151699)1, 3 Cella M.... Colonna M. (J. Exp. Med. 1997)
    10. Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro. (PubMed id 14971032)1, 9 Beinhauer B.G....Jung T. (Eur. J. Immunol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10288 HGNC: 6606 AceView: LILRB2 Ensembl:ENSG00000131042 euGenes: HUgn10288
    ECgene: LILRB2 Kegg: 10288 H-InvDB: LILRB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LILRB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LILRB2 gene:
    Search GeneIP for patents involving LILRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for LILRB2 (ILT4/CD85d)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for LILRB2 (ILT4/CD85d)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for LILRB2 (ILT4/CD85d)  
     OriGene Antibodies for LILRB2   OriGene RNAi products in human, mouse, rat for LILRB2  
     OriGene qPCR primer pairs and template standards for LILRB2   OriGene Protein Over-expression Lysate for LILRB2  
     OriGene MassSpec something-or-other for LILRB2   OriGene clones in human, mouse for LILRB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for LILRB2   OriGene Purified Protein for LILRB2  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LILRB2   OriGene Custom Protein Services for LILRB2  

     
     
     Block miRNA regulation of human, mouse, rat LILRB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LILRB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRB2 Predesigned siRNA for gene silencing in human, mouse, rat LILRB2
     QuantiFast Probe-based Assays in human, mouse, rat LILRB2 QuantiTect SYBR Green Assays in human, mouse, rat LILRB2
     Custom PCR Arrays for LILRB2 Search Chromatin IP Primers for LILRB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LILRB2  GeneGlobe Interaction Network for LILRB2
     Regulatory tfbs in LILRB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LILRB2 GenScript cDNA clones with any tag delivered in your preferred vector for LILRB2
     GenScript Custom Assay Services for LILRB2 GenScript Custom overexpressing Cell Line Services for LILRB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LILRB2 (LIRB2)
     Proteins for LILRB2
     Cell Lysates for LILRB2
     cDNA Clones for LILRB2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LILRB2 antibodies
     LILRB2 proteins
     LILRB2 lysates
     Antibodies for LILRB2
     See all of Abcam's Antibodies, Kits and Proteins for LILRB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LILRB2
     Antibodies for LILRB2
     ELISAs for LILRB2
     CLIAs for LILRB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for LILRB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB2
     SwitchGear 3'UTR luciferase reporter plasmids for LILRB2
     SwitchGear Promoter luciferase reporter plasmids for LILRB2
     Search ThermoFisher Antibodies for LILRB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LILRB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LILRB2
     LSBio Antibodies in human, mouse, rat for LILRB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LILRB2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4