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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LILRB2 Gene

protein-coding   GIFtS: 56
GCID: GC19M054777

leukocyte immunoglobulin-like receptor, subfamily B (with...
 Explore 4 diseases affiliated with
LILRB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LILRB2    

Aliases
for LILRB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 21 2
     CD85 Antigen-Like Family Member D2 3
ILT41 2 3 5     CD85d1
LIR21 2 3 5     CD85D2
MIR101 2 3 5     LILRA62
LIR-21 2 3     Eukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 62
MIR-101 2 3     Ig-Like Transcript 42
Immunoglobulin-Like Transcript 42 3     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 22
Leukocyte Immunoglobulin-Like Receptor 22 3     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 Soluble Isoform2
Monocyte/Macrophage Immunoglobulin-Like Receptor 102 3     CD85d Antigen3
ILT-42 3     

External Ids:    HGNC: 66061   Entrez Gene: 102882   Ensembl: ENSG000001310427   OMIM: 6048155   UniProtKB: Q8N4233   

Export aliases for LILRB2 gene to outside databases

Previous GC identifers: GC19M055583 GC19M055149 GC19M059454 GC19M059470 GC19M059469 GC19M051105


Summaries
for LILRB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LILRB2:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at
chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or
four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor
tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I
molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune
response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit
autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423
Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for
binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of
intracellular calcium ions

Gene Wiki entry for LILRB2


Genomic Views
for LILRB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LILRB2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LILRB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LILRB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054777:  view genomic region     (about GC identifiers)

Start:
 54,777,675 bp from pter      End:
 54,785,039 bp from pter
Size:
 7,365 bases      Orientation:
 minus strand

Proteins
for LILRB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 2 precursor  
Size: 598 amino acids; 65039 Da
Subunit: Binds PTPN6 when phosphorylated. Binds FCGR1A
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for LILRB2:
2DYP (3D)        2GW5 (3D)    
Secondary accessions: O75017 Q8NHJ7 Q8NHJ8
Alternative splicing: 2 isoforms:  Q8N423-1   Q8N423-2   (Alternative use of an acceptor site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRB2: NX_Q8N423

Post-translational modifications:

  • Phosphorylated on tyrosine residues. Dephosphorylated by PTPN61
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N423

    • LILRB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001074447.1  NP_005865.2  

    ENSEMBL proteins: 
     ENSP00000375628   ENSP00000319960   ENSP00000375629   ENSP00000375626   ENSP00000394130  
     ENSP00000410117  
    Reactome Protein details: Q8N423
    Human Recombinant Protein Products: 
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    Novus Biologicals LILRB2 Proteins
    Novus Biologicals LILRB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LILRB2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA14971032
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IDA19124746
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IC14971032


    LILRB2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for LILRB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LILRB2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8N423

    ProtoNet protein and cluster: Q8N423

    UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423
    Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the
    SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for LILRB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423
    Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
    Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for
    binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of
    intracellular calcium ions

         Genatlas biochemistry entry for LILRB2:
    leukocyte immunoglobulin-like receptor,subfamily B,member 2,expressed on monocytes,B cells,dentritic and natural killer
    cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,binding to MHC class I
    molecules A2,B44

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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9382880
    GO:0005515protein binding IPI18802077
    GO:0008157protein phosphatase 1 binding IPI9842885
    GO:0023029MHC class Ib protein binding IPI--
    GO:0032396inhibitory MHC class I receptor activity IMP14971032


    LILRB2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for LILRB2:
     Decreased Wnt reporter activit 


    Pathways & Interactions
    for LILRB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Osteoclast differentiation
    		Osteoclast differentiation1.00
    3Cleavage of Alpha-1-Microglobulin
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for LILRB2
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for LILRB2):
        Osteoclast differentiation


    LILRB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LILRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/22 Interacting proteins for LILRB2 (Q8N4233 ENSP000003756294) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-AP044393, ENSP000003660054I2D: score=1 I2D: score=1 STRING: ENSP00000366005
    HLA-BP018893, ENSP000003991684I2D: score=2 STRING: ENSP00000399168
    PTPN6P293503, ENSP000003915924I2D: score=3 STRING: ENSP00000391592
    FCGR1AP123143, ENSP000003581654I2D: score=1 STRING: ENSP00000358165
    HLA-CP103213, ENSP000003654024I2D: score=2 STRING: ENSP00000365402
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002578negative regulation of antigen processing and presentation IDA19124746
    GO:0002666positive regulation of T cell tolerance induction IMP--
    GO:0002767immune response-inhibiting cell surface receptor signaling pathway IMP14971032
    GO:0002774Fc receptor mediated inhibitory signaling pathway IDA9842885
    GO:0006955immune response TAS9079806


    LILRB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LILRB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LILRB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for LILRB2

    1 HMDB Compound for LILRB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for LILRB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 2.38 4 10399074 (1), 9842885 (1), 12853576 (1)

    Search CenterWatch for drugs/clinical trials and news about LILRB2 / LIRB2 

    Transcripts
    for LILRB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LILRB2 gene (2 alternative transcripts): 
    NM_001080978.2  NM_005874.3  

    Unigene Cluster for LILRB2:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
    Hs.655652  [show with all ESTs]
    Unigene Representative Sequence: NM_005874
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391748(uc010eri.3 uc010erj.3 uc002qfb.3 uc002qfc.3 uc010yet.2)
    ENST00000314446 ENST00000493242 ENST00000391749(uc010yeu.1) ENST00000391746
    ENST00000455108 ENST00000471216 ENST00000434421

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF000574.1 AF004231.2 AF011565.1 AF025528.1 AF283986.1 AF283987.1 AK226015.1 AK297041.1 
    AK297071.1 AK298649.1 AK310263.1 BC036827.1 DQ655938.2 EU915606.1 

    11 DOTS entries:

    DT.75189743  DT.121487035  DT.121487097  DT.102820252  DT.121487655  DT.92466952  DT.92466967  DT.99928022 
    DT.100814430  DT.100814431  DT.121487522 

    4 AceView cDNA sequences:

    AA559048 AW193552 AF283987 NM_005874 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LILRB2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -                                                         
    SP2:                                                                              
    SP3:                                                                              


    ECgene alternative splicing isoforms for LILRB2

    Expression
    for LILRB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LILRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGAGATGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See LILRB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LILRB2

    SOURCE GeneReport for Unigene cluster: Hs.655652

    UniProtKB/Swiss-Prot: LIRB2_HUMAN, Q8N423
    Tissue specificity: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels
    in natural killer (NK) cells

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    In Situ
    Assay Products:     
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    Orthologs
    for LILRB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LILRB2 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    --
    (see all 59)    		 --
    		 25(a)
    23(a)
    (see all 59)    		 many ↔ many
    many ↔ many
    (see all 59)    		 Un(51843257-51844123)
    Un(59460063-59462402)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 27(a)
    23(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343329.1(823590-844642)
    GL343329.1(1231914-1234163)


    ENSEMBL Gene Tree for LILRB2 (if available)
    TreeFam Gene Tree for LILRB2 (if available) 

    Paralogs
    for LILRB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LILRB2 gene
    KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  LILRA52  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  LILRA12  
    KIR3DL32  KIR2DL12  A1BG2  KIR2DL22  LILRA22  KIR3DL22  KIR2DL32  FCAR2  
    LILRB32  GP62  
    18/50 SIMAP similar genes for LILRB2 using alignment to 4 protein entries:     LIRB2_HUMAN (see all proteins) (see all similar genes):
    MIR cl-10    LILRA1    LILRA3    LILRB1    LILRA2    LILRB5
    LILRA6    p58    LILRB3    LILRA4    KIR-K36    KIR-K64
    KIR412    LILRB4    KIR-K15    KIR-K3    KIR-K39    KIR-K65

    LILRB2 for paralogs           About GeneDecksing



    Genomic Variants
    for LILRB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/379 NCBI SNPs in LILRB2 are shown (see all 379)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1495676751,2
    		--54777207(+) AAAAAA/GTCCTA 2 -- ds50010--------
    rs1442109681,2
    		--54777314(+) GGGGGG/TTTGTT 2 -- ds50010--------
    rs1487457081,2
    		--54777345(+) CCTCCC/TGGGTT 2 -- ds50010--------
    rs1873259241,2
    		--54777379(+) TGCCTC/TCCAAG 2 -- ds50010--------
    rs104060311,2
    		C,F,H--54777387(+) aagtaG/Actggg 2 -- ds50013Minor allele frequency- A:0.01NS NA 386
    rs1904711591,2
    		--54777431(+) TTGTAC/TTTTTA 2 -- ds50010--------
    rs1474822521,2
    		--54777677(+) TGATAC/TGATGG 2 -- ut310--------
    rs558496511,2
    		C,--54777711(+) ACACA-/CATATAT 2 -- ut311Minor allele frequency- CA:0.00NA 2
    rs1437925391,2
    		C,--54777711(+) TTTTT-/CACA  
                CACAC     		2 -- ut310--------
    rs754953981,2
    		C--54777737(+) ACACAC/TACATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LILRB2 (54777675 - 54785039 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for LILRB2
         5 CNVs: 4088 32269 5116 3199 23217

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    Disorders / Diseases
    for LILRB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LILRB2 for disorders           About GeneDecksing

    OMIM gene information: 604815    OMIM disorders: --

    4 diseases for LILRB2:    About MalaCards
    chronic lymphocytic leukemia    herpes simplex    lymphocytic leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: LILRB2 (1 document)

    Export disorders for LILRB2 gene to outside databases

    Publications
    for LILRB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LILRB2 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with LILRB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. (PubMed id 12853576)1, 2, 9 Shiroishi M.... Maenaka K. (2003)
    2. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. (PubMed id 11875462)1, 2, 9 Chang C.C....Suciu-Foca N. (2002)
    3. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor- mediated signaling in monocytes. (PubMed id 9842885)1, 2, 9 Fanger N.A....Borges L. (1998)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18. (PubMed id 12390682)1, 2 Willcox B.E....Bjorkman P.J. (2002)
    6. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2 Borges L....Cosman D. (1997)
    7. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new sti mulatory and inhibitory pathways. (PubMed id 9079806)1, 3 Samaridis J. and Colonna M. (1997)
    8. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. (PubMed id 9151699)1, 3 Cella M.... Colonna M. (1997)
    9. Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro. (PubMed id 14971032)1, 9 Beinhauer B.G....Jung T. (2004)
    10. Novel HLA-G-Binding Leukocyte Immunoglobulin-Like Receptor (LILR) Expression Patterns in Human Placentas and Umbilical Cords. (PubMed id 18538388)1, 9 McIntire R.H....Hunt J.S. (2008)

    External Searches for LILRB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing LILRB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10288 HGNC: 6606 AceView: LILRB2 Ensembl:ENSG00000131042 euGenes: HUgn10288
    ECgene: LILRB2 Kegg: 10288 H-InvDB: LILRB2

    Other Databases showing LILRB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LILRB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LILRB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LILRB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LILRB2 gene:
    Search GeneIP for patents involving LILRB2

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