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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LILRB1 Gene

protein-coding   GIFtS: 63
GCID: GC19P055085

Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 11 2
     CD85J2
ILT22 3 5     Ig-Like Transcript 22
LIR12 3 5     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 12
MIR72 3 5     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 Soluble
Isoform2
Monocyte/Macrophage Immunoglobulin-Like Receptor 72 3     CD85j Antigen3
ILT-22 3     Immunoglobulin-Like Transcript 23
LIR-12 3     Leukocyte Immunoglobulin-Like Receptor 13
MIR-72 3     CD855
CD85 Antigen-Like Family Member J2 3     

External Ids:    HGNC: 66051   Entrez Gene: 108592   Ensembl: ENSG000001049727   OMIM: 6048115   UniProtKB: Q8NHL63   

Export aliases for LILRB1 gene to outside databases

Previous GC identifers: GC19P055947 GC19P055510 GC19P059761 GC19P059776 GC19P059820 GC19P051451


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LILRB1 Gene:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster
at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which
contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic
immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds
to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation
of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune
response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for LILRB1 Gene: 
LILRB1 (leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1) is a protein-coding gene. Diseases associated with LILRB1 include cytomegalovirus infection, and autoimmune thyroiditis, and among its related super-pathways are Immune System and FCGR activation. GO annotations related to this gene include MHC class I receptor activity and protein homodimerization activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals
and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by
class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition
of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of
cellular proteins and mobilization of intracellular calcium ions

Gene Wiki entry for LILRB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LILRB1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LILRB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LILRB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055085:  view genomic region     (about GC identifiers)

Start:
55,085,346 bp from pter      End:
55,149,007 bp from pter
Size:
63,662 bases      Orientation:
plus strand

3 alternative locations:
Chr19+,NW_003571060 522,048-542,434      Chr19+,NW_003571054 479,685-543,942      Chr19+,NW_003571061 338,148-364,038     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 1 precursor  
Size: 650 amino acids; 70819 Da
Subunit: Binds PTPN6 when phosphorylated. Binds FCER1A and FCGR1A. Interacts with human cytomegalovirus/HHV-5
protein UL18
Subcellular location: Membrane; Single-pass type I membrane protein
6 PDB 3D structures from and Proteopedia for LILRB1:
1G0X (3D)        1P7Q (3D)        1UFU (3D)        1UGN (3D)        1VDG (3D)        3D2U (3D)    
Secondary accessions: A2IXV4 A8MXT0 O75024 O75025 Q8NHJ9 Q8NHK0
Alternative splicing: 4 isoforms:  Q8NHL6-1   Q8NHL6-2   Q8NHL6-3   Q8NHL6-4   

Explore the universe of human proteins at neXtProt for LILRB1: NX_Q8NHL6

Explore proteomics data for LILRB1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NHL6

  • LILRB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LILRB1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001075106.1  NP_001075107.1  NP_001075108.1  NP_001265327.1  NP_001265328.1  NP_006660.3  

    ENSEMBL proteins: 
     ENSP00000379622   ENSP00000379618   ENSP00000379623   ENSP00000395004   ENSP00000379610  
     ENSP00000379608   ENSP00000410165   ENSP00000379614   ENSP00000391514   ENSP00000409968  
     ENSP00000315997   ENSP00000405243  
    Reactome Protein details: Q8NHL6
    Human Recombinant Protein Products for LILRB1: 
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    Novus Biologicals LILRB1 Proteins
    Novus Biologicals LILRB1 Lysates
    Sino Biological Recombinant Protein for LILRB1
    Sino Biological Cell Lysate for LILRB1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LILRB1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15585844
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IDA15585844
    GO:0016021integral to membrane IEA--

    LILRB1 for ontologies           About GeneDecksing



    LILRB1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for LILRB1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8NHL6

    ProtoNet protein and cluster: Q8NHL6

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
    Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    LILRB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRB1_HUMAN, Q8NHL6
    Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
    Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals
    and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by
    class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition
    of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of
    cellular proteins and mobilization of intracellular calcium ions

         Genatlas biochemistry entry for LILRB1:
    leukocyte immunoglobulin-like receptor,subfamily B,member 1,expressed on monocytes,B cells,dentritic cells and
    natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,binding
    to MHC class I molecules A2,B44

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008157protein phosphatase 1 binding IPI11907092
    GO:0030107HLA-A specific inhibitory MHC class I receptor activity IDA18684926
    GO:0030109HLA-B specific inhibitory MHC class I receptor activity IDA11907092
    GO:0032393MHC class I receptor activity IDA17869268
         
    LILRB1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LILRB1:
     Decreased DCP1a protein expres  Decreased cell number and incr  Decreased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LILRB1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LILRB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
    3Osteoclast differentiation
    Osteoclast differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for LILRB1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for LILRB1):
        Osteoclast differentiation


    LILRB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LILRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/33 Interacting proteins for LILRB1 (Q8NHL62, 3 ENSP000003159974) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206506P176932, 3MINT-7144982 I2D: score=3 
    ENSG00000230413P176932, 3MINT-7144982 I2D: score=3 
    ENSG00000233095P176932, 3MINT-7144982 I2D: score=3 
    ENSG00000235680P176932, 3MINT-7144982 I2D: score=3 
    ENSG00000237216P176932, 3MINT-7144982 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001915negative regulation of T cell mediated cytotoxicity IDA--
    GO:0002230positive regulation of defense response to virus by host IDA18398485
    GO:0002309T cell proliferation involved in immune response IDA18094328
    GO:0002740negative regulation of cytokine secretion involved in immune response IDA18094328
    GO:0002767immune response-inhibiting cell surface receptor signaling pathway NAS18550825

    LILRB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LILRB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LILRB1 (LIRB1)

    1 HMDB Compound for LILRB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for LILRB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 19.3 10 9285411 (2), 16897816 (1), 9842885 (1), 12853576 (1) (see all 6)
    cysteine 1.4 3 17217953 (1), 17869268 (1)

    Search CenterWatch for drugs/clinical trials and news about LILRB1 / LIRB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LILRB1 gene (6 alternative transcripts): 
    NM_001081637.1  NM_001081638.2  NM_001081639.2  NM_001278398.1  NM_001278399.1  NM_006669.5  

    Unigene Cluster for LILRB1:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
    Hs.667388  [show with all ESTs]
    Unigene Representative Sequence: BC015731
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396331(uc002qgj.3) ENST00000396327 ENST00000396332(uc010err.3)
    ENST00000427581 ENST00000396317 ENST00000396315 ENST00000421584 ENST00000480257
    ENST00000473412 ENST00000462628(uc010erp.1) ENST00000487425 ENST00000480375
    ENST00000396321 ENST00000418536 ENST00000448689 ENST00000324602(uc002qgl.3 uc002qgk.3 uc002qgm.3 uc010erq.3)
    ENST00000434867
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AF009005.1 AF009006.1 AF009220.1 AF009221.1 AF283984.1 AF283985.1 AK223310.1 AK292028.1 
    AK292156.1 AK311555.1 BC015731.1 EU915608.1 U82279.1 

    17 DOTS entries:

    DT.100876154  DT.40133678  DT.121487568  DT.97774796  DT.92415976  DT.102820252  DT.121487341  DT.92466955 
    DT.121487201  DT.121487333  DT.75189743  DT.101982942  DT.121487038  DT.121487405  DT.454891  DT.92466952 
    DT.92466963 

    3 AceView cDNA sequences:

    AF283984 AI436582 NM_006669 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LILRB1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for LILRB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LILRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTGCCC
    LILRB1 Expression
    About this image


    See LILRB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LILRB1

    SOURCE GeneReport for Unigene cluster: Hs.667388

    UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
    Tissue specificity: Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells.
    Detected on a low percentage of T-cells and natural killer (NK) cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for LILRB1 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    42(a)
    possible ortholog
    1(102996666-103000872)


    ENSEMBL Gene Tree for LILRB1 (if available)
    TreeFam Gene Tree for LILRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LILRB1 gene
    LILRB42  KIR2DL42  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  LILRB22  A1BG2  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    18/54 SIMAP similar genes for LILRB1 using alignment to 11 protein entries:     LIRB1_HUMAN (see all proteins) (see all similar genes):
    LILRA3    LILRA2    LILRA1    LILRB2    MIR cl-10    LILRB3
    LILRA6    p58    LILRA4    KIR-K36    LILRB5    KIR2DS
    KIR412    KIR-K64    LILRB4    LILRA5    KIR-K65    KIR-K15

    LILRB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LILRB1
    PGOHUM00000250588


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/814 SNPs in LILRB1 are shown (see all 814)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0673164
    ----see VAR_0673162 L V mis40--------
    rs344486471,2
    C--51461148(+) TTCTTG/-ATGCA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1406505831,2
    C--55126639(+) AGTTT-/ACACACA 1 -- us2k10--------
    rs129801061,2
    C,F--55126665(+) cacacA/Gcaata 1 -- us2k15Minor allele frequency- G:0.09NA CSA 128
    rs1503014751,2
    --55126716(+) AAGGAA/GAACTA 1 -- us2k10--------
    rs72509311,2
    C,F,A--55126757(+) ACAAAC/TAGATG 1 -- us2k110Minor allele frequency- T:0.24NA WA CSA EA 371
    rs1379440751,2
    --55126759(+) AAATAC/GATGGA 1 -- us2k10--------
    rs713654731,2
    C,F--55126840(+) TAGATT/CCAGTA 1 -- us2k13Minor allele frequency- C:0.09NA 124
    rs1481627761,2
    C--55126857(+) GTATT-/AAGTTAT 1 -- us2k10--------
    rs1494563621,2
    C--55126986(+) AAACCA/GAAAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LILRB1 (55085346 - 55149007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for LILRB1 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2718879CNV Deletion23290073
    dgv17e196CNV Deletion17116639
    esv2718872CNV Deletion23290073
    dgv16e196CNV Duplication17116639
    dgv4006n71CNV Loss21882294
    nsv522872CNV Loss19592680
    nsv9760CNV Loss18304495
    nsv470158CNV Loss18288195
    dgv435n27CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for LILRB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604811    OMIM disorders: --

    20/23 diseases for LILRB1 (see all 23):    About MalaCards
    cytomegalovirus infection    autoimmune thyroiditis    tonsillitis    chagas disease
    malaria    myopathy    acute lymphoblastic leukemia    lymphoblastic leukemia
    influenza    systemic lupus erythematosus    atherosclerosis    lupus erythematosus
    multiple myeloma    tuberculosis    thyroiditis    myeloma
    rheumatoid arthritis    glioblastoma    arthritis    melanoma


    LILRB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for LILRB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cmv infection 46.6 1 14662864 (1)
    lymphoma 0 3 11337356 (3)

    Genetic Association Database (GAD): LILRB1
    Human Genome Epidemiology (HuGE) Navigator: LILRB1 (5 documents)

    Export disorders for LILRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LILRB1 gene, integrated from 9 sources (see all 149):
    (articles sorted by number of sources associating them with LILRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. (PubMed id 9285411)1, 2, 3, 9 Cosman D....Hsu M.-L. (1997)
    2. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. (PubMed id 16014635)1, 4, 9 Kuroki K....Tokunaga K. (2005)
    3. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. (PubMed id 10591185)1, 2, 9 Chapman T.L....Bjorkman P.J. (1999)
    4. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). (PubMed id 11114384)1, 2, 9 Chapman T.L.... Bjorkman P.J. (2000)
    5. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PubMed id 10941837)1, 2, 9 Liu W.R.... Arm J.P. (2000)
    6. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor- mediated signaling in monocytes. (PubMed id 9842885)1, 2, 9 Fanger N.A....Borges L. (1998)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. LILRB1 polymorphism and surface phenotypes of natural killer cells. (PubMed id 20600445)1, 2 Davidson C.L.... Burshtyn D.N. (2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. (PubMed id 11907092)1, 2 Bellon T.... Lopez-Botet M. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10859 HGNC: 6605 AceView: LILRB1 Ensembl:ENSG00000104972 euGenes: HUgn10859
    ECgene: LILRB1 Kegg: 10859 H-InvDB: LILRB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LILRB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LILRB1 gene:
    Search GeneIP for patents involving LILRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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