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LILRB1 Gene

protein-coding   GIFtS: 61
GCID: GC19P055085

Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With...

  See LILRB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 11 2
     CD85J2
ILT22 3 5     Ig-Like Transcript 22
LIR12 3 5     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 12
MIR72 3 5     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 Soluble
Isoform2
Monocyte/Macrophage Immunoglobulin-Like Receptor 72 3     CD85j Antigen3
ILT-22 3     Immunoglobulin-Like Transcript 23
LIR-12 3     Leukocyte Immunoglobulin-Like Receptor 13
MIR-72 3     CD855
CD85 Antigen-Like Family Member J2 3     

External Ids:    HGNC: 66051   Entrez Gene: 108592   Ensembl: ENSG000001049727   OMIM: 6048115   UniProtKB: Q8NHL63   

Export aliases for LILRB1 gene to outside databases

Previous GC identifers: GC19P055947 GC19P055510 GC19P059761 GC19P059776 GC19P059820 GC19P051451


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LILRB1 Gene:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster
at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which
contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic
immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds
to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation
of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune
response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for LILRB1 Gene:
LILRB1 (leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1) is a protein-coding gene. Diseases associated with LILRB1 include cytomegalovirus infection, and pre-eclampsia. GO annotations related to this gene include MHC class I protein binding and protein homodimerization activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals
and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by
class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition
of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of
cellular proteins and mobilization of intracellular calcium ions

Gene Wiki entry for LILRB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LILRB1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LILRB1 promoter sequence
   Search Chromatin IP Primers for LILRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055085:  view genomic region     (about GC identifiers)

Start:
55,085,346 bp from pter      End:
55,149,007 bp from pter
Size:
63,662 bases      Orientation:
plus strand

3 alternative locations:
Chr19+,NW_003571060 522,048-542,434      Chr19+,NW_003571054 479,685-543,942      Chr19+,NW_003571061 338,148-364,038     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 1 precursor  
Size: 650 amino acids; 70819 Da
Subunit: Binds PTPN6 when phosphorylated. Binds FCER1A and FCGR1A. Interacts with human cytomegalovirus/HHV-5
protein UL18
Selected PDB 3D structures from and Proteopedia for LILRB1 (see all 7):
1G0X (3D)        1P7Q (3D)        1UFU (3D)        1UGN (3D)        1VDG (3D)        3D2U (3D)    
Secondary accessions: A2IXV4 A8MXT0 O75024 O75025 Q8NHJ9 Q8NHK0
Alternative splicing: 4 isoforms:  Q8NHL6-1   Q8NHL6-2   Q8NHL6-3   Q8NHL6-4   

Explore the universe of human proteins at neXtProt for LILRB1: NX_Q8NHL6

Explore proteomics data for LILRB1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues. Dephosphorylated by PTPN61
  • Glycosylation2 at Asn281, Asn302, Asn341
  • Modification sites at PhosphoSitePlus

  • See LILRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001075106.1  NP_001075107.1  NP_001075108.1  NP_001265327.1  NP_001265328.1  NP_006660.3  

    ENSEMBL proteins: 
     ENSP00000379622   ENSP00000379618   ENSP00000379623   ENSP00000395004   ENSP00000379610  
     ENSP00000379608   ENSP00000410165   ENSP00000379614   ENSP00000391514   ENSP00000409968  
     ENSP00000315997   ENSP00000405243  
    Reactome Protein details: Q8NHL6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8NHL6

    ProtoNet protein and cluster: Q8NHL6

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
    Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with LILRB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRB1_HUMAN, Q8NHL6
    Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
    Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals
    and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by
    class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition
    of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of
    cellular proteins and mobilization of intracellular calcium ions

         Genatlas biochemistry entry for LILRB1:
    leukocyte immunoglobulin-like receptor,subfamily B,member 1,expressed on monocytes,B cells,dentritic cells and
    natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,binding
    to MHC class I molecules A2,B44

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008157protein phosphatase 1 binding IPI11907092
    GO:0030107HLA-A specific inhibitory MHC class I receptor activity IDA18684926
    GO:0030109HLA-B specific inhibitory MHC class I receptor activity IDA11907092
    GO:0032393MHC class I receptor activity IDA17869268
         
    Find genes that share ontologies with LILRB1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for LILRB1:
     Decreased DCP1a protein expres  Decreased cell number and incr  Decreased circadian period len 

    Animal Models:
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LILRB1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIRB1_HUMAN, Q8NHL6: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15585844
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IDA15585844
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LILRB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LILRB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Osteoclast differentiation
    Osteoclast differentiation
    3Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Find genes that share SuperPaths with LILRB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for LILRB1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    1 Kegg Pathway  (Kegg details for LILRB1):
        Osteoclast differentiation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LILRB1
    Interactions:

        GeneGlobe Interaction Network for LILRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for LILRB1 (Q8NHL62, 3 ENSP000003159974) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206506P176932, 3MINT-7144982 I2D: score=3 
    ENSG00000230413P176932, 3MINT-7144982 I2D: score=3 
    ENSG00000233095P176932, 3MINT-7144982 I2D: score=3 
    ENSG00000235680P176932, 3MINT-7144982 I2D: score=3 
    ENSG00000237216P176932, 3MINT-7144982 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001915negative regulation of T cell mediated cytotoxicity IDA--
    GO:0002230positive regulation of defense response to virus by host IDA18398485
    GO:0002309T cell proliferation involved in immune response IDA18094328
    GO:0002740negative regulation of cytokine secretion involved in immune response IDA18094328
    GO:0002767immune response-inhibiting cell surface receptor signaling pathway NAS18550825

    Find genes that share ontologies with LILRB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LILRB1 (LIRB1)

    1 HMDB Compound for LILRB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for LILRB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 19.3 10 9285411 (2), 16897816 (1), 9842885 (1), 12853576 (1) (see all 6)
    cysteine 1.4 3 17217953 (1), 17869268 (1)



    Find genes that share compounds with LILRB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LILRB1 gene (6 alternative transcripts): 
    NM_001081637.1  NM_001081638.2  NM_001081639.2  NM_001278398.1  NM_001278399.1  NM_006669.5  

    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396331(uc002qgj.3) ENST00000396327 ENST00000396332(uc010err.3)
    ENST00000427581 ENST00000396317 ENST00000396315 ENST00000421584 ENST00000480257
    ENST00000473412 ENST00000462628(uc010erp.1) ENST00000487425 ENST00000480375
    ENST00000396321 ENST00000418536 ENST00000448689 ENST00000324602(uc002qgl.3 uc002qgk.3 uc002qgm.3 uc010erq.3)
    ENST00000434867
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    3 AceView cDNA sequences:

    AI436582 AF283984 NM_006669 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LILRB1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for LILRB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LILRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTGCCC
    LILRB1 Expression
    About this image


    LILRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Larynx (Respiratory System)
     
     Spleen (Hematopoietic System)
    LILRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LILRB1 Protein Expression

    UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
    Tissue specificity: Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells.
    Detected on a low percentage of T-cells and natural killer (NK) cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LILRB1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    19(a)
    1 → many
    GL343329.1(823590-844642)
            Species with no ortholog for LILRB1

    ENSEMBL Gene Tree for LILRB1 (if available)
    TreeFam Gene Tree for LILRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LILRB1 gene
    LILRB42  KIR2DL42  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  LILRB22  A1BG2  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for LILRB1 using alignment to 11 protein entries:     LIRB1_HUMAN (see all proteins) (see all similar genes):
    LILRA3    LILRA2    LILRA1    LILRB2    MIR cl-10    LILRB3
    LILRA6    p58    LILRA4    KIR-K36    LILRB5    KIR2DS
    KIR412    KIR-K64    LILRB4    LILRA5    KIR-K65    KIR-K15

    Find genes that share paralogs with LILRB1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LILRB1
    PGOHUM00000250588


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LILRB1 (see all 814)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344486471,2
    C--51461148(+) TTCTTG/-ATGCA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1406505831,2
    C--55126639(+) AGTTT-/ACACACA 1 -- us2k10--------
    rs129801061,2
    C,F--55126665(+) cacacA/Gcaata 1 -- us2k15Minor allele frequency- G:0.09NA CSA 128
    rs1503014751,2
    --55126716(+) AAGGAA/GAACTA 1 -- us2k10--------
    rs72509311,2
    C,F,A--55126757(+) ACAAAC/TAGATG 1 -- us2k110Minor allele frequency- T:0.24NA WA CSA EA 371
    rs1379440751,2
    --55126759(+) AAATAC/GATGGA 1 -- us2k10--------
    rs713654731,2
    C,F--55126840(+) TAGATT/CCAGTA 1 -- us2k13Minor allele frequency- C:0.09NA 124
    rs1481627761,2
    C--55126857(+) GTATT-/AAGTTAT 1 -- us2k10--------
    rs1494563621,2
    C--55126986(+) AAACCA/GAAAAC 1 -- us2k10--------
    rs1459025731,2
    C--55127030(+) ACTATA/TCTACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LILRB1 (55085346 - 55149007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LILRB1 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2718879CNV Deletion23290073
    dgv17e196CNV Deletion17116639
    esv2718872CNV Deletion23290073
    dgv16e196CNV Duplication17116639
    dgv4006n71CNV Loss21882294
    nsv522872CNV Loss19592680
    nsv9760CNV Loss18304495
    nsv470158CNV Loss18288195
    dgv435n27CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604811    OMIM disorders: --

    2 diseases for LILRB1:    
    About MalaCards
    cytomegalovirus infection    pre-eclampsia


    Find genes that share disorders with LILRB1           About GenesLikeMe

    2 Novoseek inferred disease relationships for LILRB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cmv infection 46.6 1 14662864 (1)
    lymphoma 0 3 11337356 (3)

    Genetic Association Database (GAD): LILRB1
    Human Genome Epidemiology (HuGE) Navigator: LILRB1 (5 documents)

    Export disorders for LILRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LILRB1 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with LILRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. (PubMed id 9285411)1, 2, 3, 9 Cosman D....Hsu M.-L. (Immunity 1997)
    2. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. (PubMed id 16014635)1, 4, 9 Kuroki K....Tokunaga K. (Hum. Mol. Genet. 2005)
    3. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. (PubMed id 10591185)1, 2, 9 Chapman T.L.... Bjorkman P.J. (Immunity 1999)
    4. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). (PubMed id 11114384)1, 2, 9 Chapman T.L.... Bjorkman P.J. (Immunity 2000)
    5. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PubMed id 10941837)1, 2, 9 Liu W.R.... Arm J.P. (Immunogenetics 2000)
    6. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor- mediated signaling in monocytes. (PubMed id 9842885)1, 2, 9 Fanger N.A....Borges L. (Eur. J. Immunol. 1998)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. LILRB1 polymorphism and surface phenotypes of natural killer cells. (PubMed id 20600445)1, 2 Davidson C.L.... Burshtyn D.N. (Hum. Immunol. 2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. (PubMed id 11907092)1, 2 Bellon T.... Lopez-Botet M. (J. Immunol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10859 HGNC: 6605 AceView: LILRB1 Ensembl:ENSG00000104972 euGenes: HUgn10859
    ECgene: LILRB1 Kegg: 10859 H-InvDB: LILRB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LILRB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LILRB1 gene:
    Search GeneIP for patents involving LILRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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