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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LILRB1 Gene

protein-coding   GIFtS: 61
GCID: GC19P055085

leukocyte immunoglobulin-like receptor, subfamily B (with...
 Explore 18 diseases affiliated with
LILRB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LILRB1    

Aliases
for LILRB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 11 2
     CD85 Antigen-Like Family Member J2 3
ILT21 2 3 5     CD85j1
LIR11 2 3 5     CD85J2
LIR-11 2 3     Ig-Like Transcript 22
MIR-71 2 3     Leukocyte Ig-Like Receptor-12
CD851 2 5     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 12
MIR72 3 5     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 Soluble Isoform2
Immunoglobulin-Like Transcript 22 3     CD85j Antigen3
Monocyte/Macrophage Immunoglobulin-Like Receptor 72 3     Leukocyte Immunoglobulin-Like Receptor 13
ILT-22 3     

External Ids:    HGNC: 66051   Entrez Gene: 108592   Ensembl: ENSG000001049727   OMIM: 6048115   UniProtKB: Q8NHL63   

Export aliases for LILRB1 gene to outside databases

Previous GC identifers: GC19P055947 GC19P055510 GC19P059761 GC19P059776 GC19P059820 GC19P051451


Summaries
for LILRB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LILRB1:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at
chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or
four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor
tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I
molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune
response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit
autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and
down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC
molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal
triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and
mobilization of intracellular calcium ions

Gene Wiki entry for LILRB1


Genomic Views
for LILRB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LILRB1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LILRB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LILRB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055085:  view genomic region     (about GC identifiers)

Start:
 55,085,346 bp from pter      End:
 55,149,007 bp from pter
Size:
 63,662 bases      Orientation:
 plus strand

Proteins
for LILRB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 1 precursor  
Size: 650 amino acids; 70819 Da
Subunit: Binds PTPN6 when phosphorylated. Binds FCER1A and FCGR1A. Interacts with human cytomegalovirus/HHV-5 protein
UL18
Subcellular location: Membrane; Single-pass type I membrane protein
6 PDB 3D structures from and Proteopedia for LILRB1:
1G0X (3D)        1P7Q (3D)        1UFU (3D)        1UGN (3D)        1VDG (3D)        3D2U (3D)    
Secondary accessions: A2IXV4 A8MXT0 O75024 O75025 Q8NHJ9 Q8NHK0
Alternative splicing: 4 isoforms:  Q8NHL6-1   Q8NHL6-2   Q8NHL6-3   Q8NHL6-4   

Explore the universe of human proteins at neXtProt for LILRB1: NX_Q8NHL6

Post-translational modifications:

  • Phosphorylated on tyrosine residues. Dephosphorylated by PTPN61
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NHL6

    • LILRB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001075106.1  NP_001075107.1  NP_001075108.1  NP_006660.3  

    ENSEMBL proteins: 
     ENSP00000379622   ENSP00000379618   ENSP00000379623   ENSP00000395004   ENSP00000379610  
     ENSP00000379608   ENSP00000410165   ENSP00000379614   ENSP00000391514   ENSP00000409968  
     ENSP00000315997   ENSP00000405243  
    Reactome Protein details: Q8NHL6
    Human Recombinant Protein Products: 
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    Novus Biologicals LILRB1 Proteins
    Novus Biologicals LILRB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LILRB1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15585844
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IDA15585844
    GO:0016021integral to membrane IEA--


    LILRB1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for LILRB1

    Protein Domains /
    Families
    for LILRB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LILRB1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8NHL6

    ProtoNet protein and cluster: Q8NHL6

    1 Blocks protein family: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
    Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the
    SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for LILRB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
    Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
    Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and
    down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC
    molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal
    triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and
    mobilization of intracellular calcium ions

         Genatlas biochemistry entry for LILRB1:
    leukocyte immunoglobulin-like receptor,subfamily B,member 1,expressed on monocytes,B cells,dentritic cells and natural
    killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,binding to MHC class
    I molecules A2,B44

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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008157protein phosphatase 1 binding IPI11907092
    GO:0030107HLA-A specific inhibitory MHC class I receptor activity IDA18684926
    GO:0030109HLA-B specific inhibitory MHC class I receptor activity IDA11907092
    GO:0032393MHC class I receptor activity IDA--
    GO:0042169SH2 domain binding IDA11907092


    LILRB1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for LILRB1:
     Decreased DCP1a protein expres  Decreased cell number and incr  Decreased circadian period len 


    Pathways & Interactions
    for LILRB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Osteoclast differentiation
    		Osteoclast differentiation1.00
    3Cleavage of Alpha-1-Microglobulin
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for LILRB1
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for LILRB1):
        Osteoclast differentiation


    LILRB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LILRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/22 Interacting proteins for LILRB1 (Q8NHL62, 3 ENSP000003159974) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412402, 3, ENSP000002200034MINT-8027342 MINT-8027327 I2D: score=2 STRING: ENSP00000220003
    HLA-AP304433, ENSP000003660054I2D: score=1 I2D: score=1 I2D: score=1 STRING: ENSP00000366005
    HLA-GP176932, 3, ENSP000003534724MINT-7144982 I2D: score=3 STRING: ENSP00000353472
    B2MP617693, ENSP000003408584I2D: score=2 STRING: ENSP00000340858
    HLA-BP018893, ENSP000003991684I2D: score=2 STRING: ENSP00000399168
    About this table

    Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001915negative regulation of T cell mediated cytotoxicity IDA--
    GO:0002230positive regulation of defense response to virus by host IDA18398485
    GO:0002309T cell proliferation involved in immune response IDA18094328
    GO:0002740negative regulation of cytokine secretion involved in immune response IDA18094328
    GO:0002767immune response-inhibiting cell surface receptor signaling pathway NAS18550825


    LILRB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LILRB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LILRB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LILRB1

    1 HMDB Compound for LILRB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    2 Novoseek chemical compound relationships for LILRB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 19.3 10 9285411 (2), 16897816 (1), 9842885 (1), 12853576 (1) (see all 6)
    cysteine 1.4 3 17217953 (1), 17869268 (1)

    Search CenterWatch for drugs/clinical trials and news about LILRB1 / LIRB1 

    Transcripts
    for LILRB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LILRB1 gene (4 alternative transcripts): 
    NM_001081637.1  NM_001081638.1  NM_001081639.1  NM_006669.3  

    Unigene Cluster for LILRB1:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
    Hs.667388  [show with all ESTs]
    Unigene Representative Sequence: BC015731
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396331(uc002qgj.3) ENST00000396327 ENST00000396332(uc010err.3)
    ENST00000427581 ENST00000396317 ENST00000396315 ENST00000421584 ENST00000480257
    ENST00000473412 ENST00000462628(uc010erp.1) ENST00000487425 ENST00000480375
    ENST00000396321 ENST00000418536 ENST00000448689 ENST00000324602(uc002qgl.3 uc002qgk.3 uc002qgm.3 uc010erq.3)
    ENST00000434867

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF009005.1 AF009006.1 AF009220.1 AF009221.1 AF283984.1 AF283985.1 AK223310.1 AK292028.1 
    AK292156.1 AK311555.1 BC015731.1 EU915608.1 U82279.1 

    17 DOTS entries:

    DT.100876154  DT.40133678  DT.121487568  DT.97774796  DT.92415976  DT.102820252  DT.121487341  DT.92466955 
    DT.121487201  DT.121487333  DT.75189743  DT.101982942  DT.121487038  DT.121487405  DT.454891  DT.92466952 
    DT.92466963 

    3 AceView cDNA sequences:

    AI436582 AF283984 NM_006669 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LILRB1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for LILRB1

    Expression
    for LILRB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LILRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGCTGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See LILRB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LILRB1

    SOURCE GeneReport for Unigene cluster: Hs.667388

    UniProtKB/Swiss-Prot: LIRB1_HUMAN, Q8NHL6
    Tissue specificity: Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected
    on a low percentage of T-cells and natural killer (NK) cells

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    In Situ
    Assay Products:     
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    Orthologs
    for LILRB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LILRB1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    --
    (see all 59)    		 --
    		 28(a)
    26(a)
    (see all 59)    		 many ↔ many
    many ↔ many
    (see all 59)    		 Un(51843257-51844123)
    Un(10797126-10797984)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 27(a)
    23(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343329.1(823590-844642)
    GL343329.1(1231914-1234163)


    ENSEMBL Gene Tree for LILRB1 (if available)
    TreeFam Gene Tree for LILRB1 (if available) 

    Paralogs
    for LILRB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LILRB1 gene
    KIR2DL42  LILRB42  LILRA62  IGSF12  LILRA52  KIR3DL12  OSCAR2  NCR12  
    LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  LILRA12  KIR3DL32  
    KIR2DL12  LILRB22  A1BG2  KIR2DL22  LILRA22  KIR3DL22  KIR2DL32  FCAR2  
    LILRB32  GP62  
    18/54 SIMAP similar genes for LILRB1 using alignment to 11 protein entries:     LIRB1_HUMAN (see all proteins) (see all similar genes):
    LILRA3    LILRA2    LILRA1    LILRB2    MIR cl-10    LILRB3
    LILRA6    p58    LILRA4    KIR-K36    LILRB5    KIR2DS
    KIR412    LILRB4    KIR-K64    LILRA5    KIR-K65    KIR-K15

    LILRB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LILRB1
    PGOHUM00000250588


    Genomic Variants
    for LILRB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/601 NCBI SNPs in LILRB1 are shown (see all 601)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs556351221,2
    		C--51452094(+) GTGTG-/TGT   
       GTGTG    GTGTG     		1 -- int12Minor allele frequency- TGTGTGTG:0.25NA 4
    rs1406505831,2
    		--55126639(+) AGTTT-/ACACACA 1 -- us2k10--------
    rs129801061,2
    		C,F,--55126665(+) cacacA/Gcaata 1 -- us2k15Minor allele frequency- G:0.09NA CSA 128
    rs1503014751,2
    		--55126716(+) AAGGAA/GAACTA 1 -- us2k10--------
    rs72509311,2
    		C,F,A,--55126757(+) ACAAAC/TAGATG 1 -- us2k110Minor allele frequency- T:0.24NA WA CSA EA 371
    rs1379440751,2
    		--55126759(+) AAATAC/GATGGA 1 -- us2k10--------
    rs713654731,2
    		C,F,--55126840(+) TAGATT/CCAGTA 1 -- us2k13Minor allele frequency- C:0.09NA 124
    rs1481627761,2
    		C,--55126857(+) GTATT-/AAGTTAT 1 -- us2k10--------
    rs1494563621,2
    		--55126986(+) AAACCA/GAAAAC 1 -- us2k10--------
    rs1459025731,2
    		--55127030(+) ACTATA/TCTACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LILRB1 (55085346 - 55149007 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for LILRB1
         9 CNVs: 4088 30083 32270 30082 29696 5345 5447 10568 53601

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    Disorders / Diseases
    for LILRB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LILRB1 for disorders           About GeneDecksing

    OMIM gene information: 604811    OMIM disorders: --

    18 diseases for LILRB1:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    cytomegalovirus infection    acute lymphoblastic leukemia
    lymphoblastic leukemia    myopathy    autoimmune thyroiditis    rheumatoid arthritis
    tonsillitis    arthritis    influenza    thyroiditis
    leukemia    atherosclerosis    tuberculosis    melanoma
    malaria    mycobacterium tuberculosis

    2 Novoseek disease relationships for LILRB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cmv infection 46.6 1 14662864 (1)
    lymphoma 0 3 11337356 (3)

    Genetic Association Database (GAD): LILRB1
    Human Genome Epidemiology (HuGE) Navigator: LILRB1 (5 documents)

    Export disorders for LILRB1 gene to outside databases

    Publications
    for LILRB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LILRB1 gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with LILRB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. (PubMed id 9285411)1, 2, 3, 9 Cosman D....Hsu M.-L. (1997)
    2. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. (PubMed id 16014635)1, 4, 9 Kuroki K....Tokunaga K. (2005)
    3. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. (PubMed id 10591185)1, 2, 9 Chapman T.L....Bjorkman P.J. (1999)
    4. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). (PubMed id 11114384)1, 2, 9 Chapman T.L.... Bjorkman P.J. (2000)
    5. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PubMed id 10941837)1, 2, 9 Liu W.R.... Arm J.P. (2000)
    6. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor- mediated signaling in monocytes. (PubMed id 9842885)1, 2, 9 Fanger N.A....Borges L. (1998)
    7. LILRB1 polymorphism and surface phenotypes of natural killer cells. (PubMed id 20600445)1, 2 Davidson C.L.... Burshtyn D.N. (2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. (PubMed id 11907092)1, 2 Bellon T.... Lopez-Botet M. (2002)
    10. A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors. (PubMed id 9259559)1, 2 Wagtmann N.... Long E.O. (1997)

    External Searches for LILRB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LILRB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10859 HGNC: 6605 AceView: LILRB1 Ensembl:ENSG00000104972 euGenes: HUgn10859
    ECgene: LILRB1 Kegg: 10859 H-InvDB: LILRB1

    Other Databases showing LILRB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LILRB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LILRB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LILRB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LILRB1 gene:
    Search GeneIP for patents involving LILRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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