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Aliases for LILRA6 Gene

Aliases for LILRA6 Gene

  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 6 2 3
  • Immunoglobulin-Like Transcript 8 3 4
  • Leukocyte Ig-Like Receptor 3 4
  • ILT-8 3 4
  • ILT8 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 6 3
  • Immunoglobulin-Like Transcript 5 3
  • LILRB3 3
  • LILRB6 3
  • CD85b 3
  • ILT5 3

External Ids for LILRA6 Gene

Previous HGNC Symbols for LILRA6 Gene

  • LILRB6

Previous GeneCards Identifiers for LILRA6 Gene

  • GC19M059413
  • GC19M054740
  • GC19M054721

Summaries for LILRA6 Gene

GeneCards Summary for LILRA6 Gene

LILRA6 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Spinal Cord Injury. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRA6 Gene

  • May act as receptor for class I MHC antigens.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA6 Gene

Genomics for LILRA6 Gene

Regulatory Elements for LILRA6 Gene

Genomic Location for LILRA6 Gene

54,216,868 bp from pter
54,242,991 bp from pter
26,124 bases
Minus strand

Genomic View for LILRA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LILRA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA6 Gene

Proteins for LILRA6 Gene

  • Protein details for LILRA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 6
    Protein Accession:
    Secondary Accessions:

    Protein attributes for LILRA6 Gene

    481 amino acids
    Molecular mass:
    52399 Da
    Quaternary structure:
    No Data Available
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4

    Alternative splice isoforms for LILRA6 Gene


neXtProt entry for LILRA6 Gene

Proteomics data for LILRA6 Gene at MOPED

Post-translational modifications for LILRA6 Gene

  • Glycosylation at Asn139, Asn280, Asn301, and Asn340
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA6 Gene

No data available for DME Specific Peptides for LILRA6 Gene

Domains for LILRA6 Gene

Gene Families for LILRA6 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • LILR :Leukocyte immunoglobulin-like receptors

Protein Domains for LILRA6 Gene

Suggested Antigen Peptide Sequences for LILRA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6PI73
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA6: view

Function for LILRA6 Gene

Molecular function for LILRA6 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.

Gene Ontology (GO) - Molecular Function for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LILRA6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LILRA6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LILRA6 Gene

Localization for LILRA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LILRA6 Gene COMPARTMENTS Subcellular localization image for LILRA6 gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA6: view

Pathways for LILRA6 Gene

genes like me logo Genes that share pathways with LILRA6: view

Pathways by source for LILRA6 Gene

Interacting Proteins for LILRA6 Gene

Gene Ontology (GO) - Biological Process for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LILRA6: view

Transcripts for LILRA6 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LILRA6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA6 Gene

No ASD Table

Relevant External Links for LILRA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRA6 Gene

mRNA expression in normal human tissues for LILRA6 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA6 Gene

This gene is overexpressed in Whole Blood (38.4) and Spleen (4.5).

Protein differential expression in normal tissues for LILRA6 Gene

This gene is overexpressed in Monocytes (61.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LILRA6 Gene

genes like me logo Genes that share expressions with LILRA6: view

Expression partners for LILRA6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LILRA6 Gene

Orthologs for LILRA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRA6 35
  • 93.56 (n)
  • 89.19 (a)
  • 64 (a)
(Rattus norvegicus)
Mammalia Lilra3 35
  • 68.27 (n)
  • 56.11 (a)
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
-- 36
  • 27 (a)
-- 36
  • 42 (a)
-- 36
  • 54 (a)
-- 36
  • 67 (a)
-- 36
  • 50 (a)
-- 36
  • 51 (a)
-- 36
  • 36 (a)
-- 36
  • 55 (a)
-- 36
  • 49 (a)
  • 60 (a)
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
-- 36
  • 46 (a)
(Mus musculus)
Mammalia Gm15448 36
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
Species with no ortholog for LILRA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA6 Gene

Gene Tree for LILRA6 (if available)
Gene Tree for LILRA6 (if available)

Paralogs for LILRA6 Gene

genes like me logo Genes that share paralogs with LILRA6: view

Variants for LILRA6 Gene

Sequence variations from dbSNP and Humsavar for LILRA6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs620207 - 54,242,175(-) GCCCT(G/T)GGACA reference, missense, nc-transcript-variant
rs635711 -- 54,244,919(-) tccag(A/C)gattc upstream-variant-2KB
rs1052963 -- 54,242,113(-) TGACA(C/G)AGCAC missense, reference, nc-transcript-variant
rs1052964 -- 54,242,102(-) CATGC(A/G)GGGAG synonymous-codon, reference, nc-transcript-variant
rs1052984 -- 54,240,490(-) AGTCA(C/T)GGGGT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for LILRA6 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv510774 CNV Loss 20534489
dgv1118e1 CNV Complex 17122850
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
nsv2546 CNV Loss 18451855
nsv458783 CNV Loss 19166990
essv101799 CNV Loss 18971310
dgv1120e1 CNV Complex 17122850
dgv1121e1 CNV Complex 17122850
dgv1122e1 CNV Complex 17122850
dgv432n27 CNV Loss 19166990
nsv912399 CNV Loss 21882294
nsv183 CNV Loss 15895083
nsv517129 CNV Gain+Loss 19592680
dgv4003n71 CNV Loss 21882294
nsv912402 CNV Gain 21882294
esv1003658 CNV Gain 20482838
nsv912403 CNV Gain 21882294
nsv912404 CNV Gain+Loss 21882294
nsv912405 CNV Loss 21882294
nsv9752 CNV Gain+Loss 18304495
esv2718859 CNV Deletion 23290073
esv6034 CNV Loss 19470904
esv23225 CNV Gain+Loss 19812545
dgv598n67 CNV Gain 20364138
dgv1123e1 CNV Complex 17122850
dgv1124e1 CNV Complex 17122850
dgv1125e1 CNV Complex 17122850
nsv513760 CNV Insertion 21212237
esv2718860 CNV Deletion 23290073
nsv498906 CNV Loss 21111241
dgv77e180 CNV Gain 20482838
esv2663554 CNV Deletion 23128226
esv32835 CNV Gain 17666407
nsv442773 CNV CNV 18776908
esv2421809 OTHER Complex 20811451
dgv433n27 CNV Loss 19166990
nsv433320 CNV Loss 18776910
nsv817868 CNV Gain+Loss 17921354
nsv433322 CNV Loss 18776910
nsv817869 CNV Loss 17921354
dgv434n27 CNV Gain 19166990
nsv817870 CNV Gain 17921354
esv1006598 CNV Insertion 20482838
dgv4004n71 CNV Loss 21882294
nsv2548 CNV Insertion 18451855

Relevant External Links for LILRA6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA6 Gene

Disorders for LILRA6 Gene

Relevant External Links for LILRA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for LILRA6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for LILRA6 Gene

Publications for LILRA6 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 3 4
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 48
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for LILRA6 Gene

Sources for LILRA6 Gene

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