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Aliases for LILRA6 Gene

Aliases for LILRA6 Gene

  • Leukocyte Immunoglobulin Like Receptor A6 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 6 2 3
  • Immunoglobulin-Like Transcript 8 3 4
  • Leucocyte Ig-Like Receptor A6 2 3
  • Leukocyte Ig-Like Receptor 3 4
  • ILT-8 3 4
  • ILT8 3 4
  • Immunoglobulin-Like Transcript 5 3
  • LILRB3 3
  • LILRB6 3
  • CD85b 3
  • ILT5 3

External Ids for LILRA6 Gene

Previous HGNC Symbols for LILRA6 Gene

  • LILRB6

Previous GeneCards Identifiers for LILRA6 Gene

  • GC19M059413
  • GC19M054740
  • GC19M054721
  • GC19M054260
  • GC19M054277

Summaries for LILRA6 Gene

GeneCards Summary for LILRA6 Gene

LILRA6 (Leukocyte Immunoglobulin Like Receptor A6) is a Protein Coding gene. Among its related pathways are Immune System and Osteoclast differentiation. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRA6 Gene

  • May act as receptor for class I MHC antigens.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA6 Gene

Genomics for LILRA6 Gene

Regulatory Elements for LILRA6 Gene

Enhancers for LILRA6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LILRA6 on UCSC Golden Path with GeneCards custom track

Promoters for LILRA6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LILRA6 on UCSC Golden Path with GeneCards custom track

Genomic Location for LILRA6 Gene

54,236,592 bp from pter
54,242,791 bp from pter
6,200 bases
Minus strand

Genomic View for LILRA6 Gene

Genes around LILRA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA6 Gene

Proteins for LILRA6 Gene

  • Protein details for LILRA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 6
    Protein Accession:

    Protein attributes for LILRA6 Gene

    481 amino acids
    Molecular mass:
    52399 Da
    Quaternary structure:
    No Data Available
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

    Alternative splice isoforms for LILRA6 Gene


neXtProt entry for LILRA6 Gene

Proteomics data for LILRA6 Gene at MOPED

Post-translational modifications for LILRA6 Gene

  • Glycosylation at Asn 139, Asn 280, Asn 301, and Asn 340
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LILRA6 Gene

Domains & Families for LILRA6 Gene

Protein Domains for LILRA6 Gene

Suggested Antigen Peptide Sequences for LILRA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA6: view

Function for LILRA6 Gene

Molecular function for LILRA6 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.

Phenotypes for LILRA6 Gene

GenomeRNAi human phenotypes for LILRA6:
genes like me logo Genes that share phenotypes with LILRA6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LILRA6 Gene

Localization for LILRA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LILRA6 Gene COMPARTMENTS Subcellular localization image for LILRA6 gene
Compartment Confidence
plasma membrane 3
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for LILRA6 Gene

Pathways & Interactions for LILRA6 Gene

genes like me logo Genes that share pathways with LILRA6: view

Pathways by source for LILRA6 Gene

Interacting Proteins for LILRA6 Gene

Gene Ontology (GO) - Biological Process for LILRA6 Gene


No data available for SIGNOR curated interactions for LILRA6 Gene

Drugs & Compounds for LILRA6 Gene

No Compound Related Data Available

Transcripts for LILRA6 Gene

mRNA/cDNA for LILRA6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA6 Gene

No ASD Table

Relevant External Links for LILRA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRA6 Gene

mRNA expression in normal human tissues for LILRA6 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA6 Gene

This gene is overexpressed in Whole Blood (x38.4) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for LILRA6 Gene

This gene is overexpressed in Monocytes (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRA6 Gene

genes like me logo Genes that share expression patterns with LILRA6: view

Protein tissue co-expression partners for LILRA6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LILRA6 Gene

Orthologs for LILRA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRA6 35
  • 93.56 (n)
  • 89.19 (a)
  • 64 (a)
(Rattus norvegicus)
Mammalia Lilra3 35
  • 68.27 (n)
  • 56.11 (a)
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
-- 36
  • 27 (a)
-- 36
  • 42 (a)
-- 36
  • 54 (a)
-- 36
  • 67 (a)
-- 36
  • 50 (a)
-- 36
  • 51 (a)
-- 36
  • 36 (a)
-- 36
  • 55 (a)
-- 36
  • 49 (a)
  • 60 (a)
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
-- 36
  • 46 (a)
(Mus musculus)
Mammalia Gm15448 36
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
Species with no ortholog for LILRA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA6 Gene

Gene Tree for LILRA6 (if available)
Gene Tree for LILRA6 (if available)

Paralogs for LILRA6 Gene

genes like me logo Genes that share paralogs with LILRA6: view

Variants for LILRA6 Gene

Sequence variations from dbSNP and Humsavar for LILRA6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_033170 -
VAR_033171 -
VAR_033172 -
VAR_033173 -

Structural Variations from Database of Genomic Variants (DGV) for LILRA6 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv510774 CNV Loss 20534489
dgv1118e1 CNV Complex 17122850
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
nsv2546 CNV Loss 18451855
nsv458783 CNV Loss 19166990
essv101799 CNV Loss 18971310
dgv1120e1 CNV Complex 17122850
dgv1121e1 CNV Complex 17122850
dgv1122e1 CNV Complex 17122850
dgv432n27 CNV Loss 19166990
nsv912399 CNV Loss 21882294
nsv183 CNV Loss 15895083
nsv517129 CNV Gain+Loss 19592680
dgv4003n71 CNV Loss 21882294
nsv912402 CNV Gain 21882294
esv1003658 CNV Gain 20482838
nsv912403 CNV Gain 21882294
nsv912404 CNV Gain+Loss 21882294
nsv912405 CNV Loss 21882294
nsv9752 CNV Gain+Loss 18304495
esv2718859 CNV Deletion 23290073
esv6034 CNV Loss 19470904
esv23225 CNV Gain+Loss 19812545
dgv598n67 CNV Gain 20364138
dgv1123e1 CNV Complex 17122850
dgv1124e1 CNV Complex 17122850
dgv1125e1 CNV Complex 17122850
nsv513760 CNV Insertion 21212237
esv2718860 CNV Deletion 23290073
nsv498906 CNV Loss 21111241
dgv77e180 CNV Gain 20482838
esv2663554 CNV Deletion 23128226
esv32835 CNV Gain 17666407
nsv442773 CNV CNV 18776908
esv2421809 OTHER Complex 20811451
dgv433n27 CNV Loss 19166990
nsv433320 CNV Loss 18776910
nsv817868 CNV Gain+Loss 17921354
nsv433322 CNV Loss 18776910
nsv817869 CNV Loss 17921354
dgv434n27 CNV Gain 19166990
nsv817870 CNV Gain 17921354
esv1006598 CNV Insertion 20482838
dgv4004n71 CNV Loss 21882294
nsv2548 CNV Insertion 18451855

Variation tolerance for LILRA6 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LILRA6 Gene

Disorders for LILRA6 Gene

Relevant External Links for LILRA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LILRA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA6 Gene

Publications for LILRA6 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 3 4 67
  2. Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair. (PMID: 24096970) Bashirova A.A. … Carrington M. (Immunogenetics 2014) 3
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3
  4. Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients. (PMID: 19617579) Pfistershammer K. … Steinberger P. (Blood 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for LILRA6 Gene

Sources for LILRA6 Gene