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Aliases for LILRA6 Gene

Aliases for LILRA6 Gene

  • Leukocyte Immunoglobulin Like Receptor A6 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 6 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6 2 3
  • Immunoglobulin-Like Transcript 8 3 4
  • Leucocyte Ig-Like Receptor A6 2 3
  • Leukocyte Ig-Like Receptor 3 4
  • ILT-8 3 4
  • ILT8 3 4
  • LOW QUALITY PROTEIN: Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 6 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 6 3
  • Immunoglobulin-Like Transcript 5 3
  • LILRB3 3
  • LILRB6 3
  • CD85b 3
  • ILT5 3

External Ids for LILRA6 Gene

Previous HGNC Symbols for LILRA6 Gene

  • LILRB6

Previous GeneCards Identifiers for LILRA6 Gene

  • GC19M059413
  • GC19M054740
  • GC19M054721
  • GC19M054260
  • GC19M054277
  • GC19M054284
  • GC19M054287
  • GC19M054290

Summaries for LILRA6 Gene

GeneCards Summary for LILRA6 Gene

LILRA6 (Leukocyte Immunoglobulin Like Receptor A6) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. An important paralog of this gene is LILRB3.

UniProtKB/Swiss-Prot for LILRA6 Gene

  • May act as receptor for class I MHC antigens.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA6 Gene

Genomics for LILRA6 Gene

Regulatory Elements for LILRA6 Gene

Enhancers for LILRA6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G054199 1.9 FANTOM5 ENCODE dbSUPER 22.4 +37.1 37081 12.1 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 LILRB5 RPS9 PRPF31 LILRB3 LILRA6 LILRA2 LILRA4 VSTM1 LILRA5 ENSG00000249189
GH19G054282 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -40.2 -40159 1.1 KLF1 POLR2A NRF1 IKZF1 LILRB3 LAIR1 LILRA6 LILRB5 ENSG00000249189 OSCAR MYADM LILRB2 VSTM1 LILRB1
GH19G054318 1.3 FANTOM5 Ensembl ENCODE 13.4 -76.3 -76310 1.0 MTA2 RNF2 CEBPG TBX21 ATF2 ATF3 IKZF1 TARDBP EED NBN LILRB2 LILRB3 LAIR1 LILRA6 TTYH1 ENSG00000227407 LILRB5 ENSG00000249189 CNOT3 ENSG00000237017
GH19G054186 1.4 ENCODE dbSUPER 11.6 +53.2 53170 6.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 PRPF31 ZNF845 LENG8-AS1 ZNF525 ENSG00000235681 LILRB3 LILRA6 ENSG00000249189 LILRB5 ZNF677
GH19G054247 1.1 Ensembl ENCODE dbSUPER 8.9 -5.2 -5204 1.6 BCOR SMARCA5 ZMYM3 ZKSCAN1 NR2F2 POLR2A EED ETV6 FOS LILRA6 LILRA4 GC19M054312 ENSG00000249189
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LILRA6 on UCSC Golden Path with GeneCards custom track

Genomic Location for LILRA6 Gene

Chromosome:
19
Start:
54,236,592 bp from pter
End:
54,242,791 bp from pter
Size:
6,200 bases
Orientation:
Minus strand

Genomic View for LILRA6 Gene

Genes around LILRA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA6 Gene

Proteins for LILRA6 Gene

  • Protein details for LILRA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI73-LIRA6_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 6
    Protein Accession:
    Q6PI73

    Protein attributes for LILRA6 Gene

    Size:
    481 amino acids
    Molecular mass:
    52399 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

    Alternative splice isoforms for LILRA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA6 Gene

Post-translational modifications for LILRA6 Gene

  • Glycosylation at posLast=139139, isoforms=280, posLast=301301, and isoforms=340
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA6 Gene

No data available for DME Specific Peptides for LILRA6 Gene

Domains & Families for LILRA6 Gene

Suggested Antigen Peptide Sequences for LILRA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LILRA6: view

No data available for UniProtKB/Swiss-Prot for LILRA6 Gene

Function for LILRA6 Gene

Molecular function for LILRA6 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.

Phenotypes for LILRA6 Gene

GenomeRNAi human phenotypes for LILRA6:
genes like me logo Genes that share phenotypes with LILRA6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LILRA6 Gene

Localization for LILRA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA6 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA6: view

Pathways & Interactions for LILRA6 Gene

genes like me logo Genes that share pathways with LILRA6: view

Pathways by source for LILRA6 Gene

Gene Ontology (GO) - Biological Process for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LILRA6: view

No data available for SIGNOR curated interactions for LILRA6 Gene

Transcripts for LILRA6 Gene

mRNA/cDNA for LILRA6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA6 Gene

No ASD Table

Relevant External Links for LILRA6 Gene

GeneLoc Exon Structure for
LILRA6
ECgene alternative splicing isoforms for
LILRA6

Expression for LILRA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRA6 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA6 Gene

This gene is overexpressed in Whole Blood (x38.4) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for LILRA6 Gene

This gene is overexpressed in Monocytes (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRA6 Gene



Protein tissue co-expression partners for LILRA6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LILRA6 Gene:

LILRA6

Evidence on tissue expression from TISSUES for LILRA6 Gene

  • Blood(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with LILRA6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA6 Gene

Orthologs for LILRA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRA6 34
  • 93.56 (n)
LIRD 35
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Lilra3 34
  • 68.27 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 67 (a)
ManyToMany
LILRA4 35
  • 60 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm15448 35
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 20 (a)
OneToMany
Species where no ortholog for LILRA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA6 Gene

ENSEMBL:
Gene Tree for LILRA6 (if available)
TreeFam:
Gene Tree for LILRA6 (if available)

Paralogs for LILRA6 Gene

Pseudogenes.org Pseudogenes for LILRA6 Gene

genes like me logo Genes that share paralogs with LILRA6: view

Variants for LILRA6 Gene

Sequence variations from dbSNP and Humsavar for LILRA6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1052966 --
rs1052975 --
rs620207 --
rs8104206 --

Structural Variations from Database of Genomic Variants (DGV) for LILRA6 Gene

Variant ID Type Subtype PubMed ID
dgv1072e212 CNV gain 25503493
dgv1073e212 CNV loss 25503493
dgv1074e212 CNV gain 25503493
dgv1075e212 CNV gain 25503493
dgv2026e59 CNV duplication 20981092
dgv3654n100 CNV gain 25217958
dgv3655n100 CNV gain 25217958
dgv3656n100 CNV gain 25217958
dgv3657n100 CNV gain 25217958
dgv3658n100 CNV gain+loss 25217958
dgv3659n100 CNV gain+loss 25217958
dgv3660n100 CNV gain 25217958
dgv432n27 CNV loss 19166990
dgv433n27 CNV loss 19166990
dgv434n27 CNV gain 19166990
dgv598n67 CNV gain 20364138
dgv6548n54 CNV gain 21841781
dgv6549n54 CNV gain 21841781
dgv6551n54 CNV loss 21841781
dgv6555n54 CNV gain 21841781
dgv671e214 CNV gain 21293372
dgv77e180 CNV gain 20482838
esv1003658 CNV gain 20482838
esv1006598 CNV insertion 20482838
esv23225 CNV gain+loss 19812545
esv2421809 OTHER complex 20811451
esv2663554 CNV deletion 23128226
esv2718812 CNV deletion 23290073
esv2718859 CNV deletion 23290073
esv2718860 CNV deletion 23290073
esv2756707 CNV loss 18971310
esv2758771 CNV gain+loss 17122850
esv2760520 CNV gain+loss 21179565
esv2763032 CNV gain+loss 21179565
esv32835 CNV gain 17666407
esv3390177 CNV duplication 20981092
esv3574853 CNV gain 25503493
esv3584744 CNV loss 24956385
esv3644786 CNV loss 21293372
esv3893247 CNV loss 25118596
esv6034 CNV loss 19470904
nsv1057076 CNV loss 25217958
nsv1060193 CNV gain 25217958
nsv1061096 CNV gain+loss 25217958
nsv1066425 CNV gain 25217958
nsv1115551 CNV duplication 24896259
nsv1131442 CNV deletion 24896259
nsv1132481 CNV duplication 24896259
nsv1142120 CNV deletion 24896259
nsv1151876 CNV duplication 26484159
nsv1160663 OTHER complex 26073780
nsv183 CNV deletion 15895083
nsv2546 CNV deletion 18451855
nsv2548 CNV insertion 18451855
nsv428371 CNV gain+loss 18775914
nsv433320 CNV loss 18776910
nsv433322 CNV loss 18776910
nsv442773 CNV gain+loss 18776908
nsv458783 CNV loss 19166990
nsv498906 CNV loss 21111241
nsv510774 CNV deletion 20534489
nsv513760 CNV insertion 21212237
nsv517129 CNV gain+loss 19592680
nsv580148 CNV loss 21841781
nsv580149 CNV gain 21841781
nsv580150 CNV loss 21841781
nsv580191 CNV gain 21841781
nsv580192 CNV gain+loss 21841781
nsv580193 CNV gain 21841781
nsv580227 CNV loss 21841781
nsv817868 CNV gain+loss 17921354
nsv817869 CNV loss 17921354
nsv817870 CNV gain 17921354
nsv953615 CNV deletion 24416366
nsv960942 OTHER complex 23825009
nsv9752 CNV gain+loss 18304495
nsv978848 CNV duplication 23825009

Variation tolerance for LILRA6 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA6 Gene

Disorders for LILRA6 Gene

Relevant External Links for LILRA6

Genetic Association Database (GAD)
LILRA6
Human Genome Epidemiology (HuGE) Navigator
LILRA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRA6

No disorders were found for LILRA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA6 Gene

Publications for LILRA6 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 3 4 64
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. LILRA6 copy number variation correlates with susceptibility to atopic dermatitis. (PMID: 27333811) LA^pez-A8lvarez M.R. … Traherne J.A. (Immunogenetics 2016) 3 64

Products for LILRA6 Gene

Sources for LILRA6 Gene

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