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Aliases for LILRA6 Gene

Aliases for LILRA6 Gene

  • Leukocyte Immunoglobulin Like Receptor A6 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 6 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 6 2 3
  • Immunoglobulin-Like Transcript 8 3 4
  • Leucocyte Ig-Like Receptor A6 2 3
  • Leukocyte Ig-Like Receptor 3 4
  • ILT-8 3 4
  • ILT8 3 4
  • LOW QUALITY PROTEIN: Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 6 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 6 3
  • Immunoglobulin-Like Transcript 5 3
  • LILRB3 3
  • LILRB6 3
  • CD85b 3
  • ILT5 3

External Ids for LILRA6 Gene

Previous HGNC Symbols for LILRA6 Gene

  • LILRB6

Previous GeneCards Identifiers for LILRA6 Gene

  • GC19M059413
  • GC19M054740
  • GC19M054721
  • GC19M054260
  • GC19M054277
  • GC19M054284
  • GC19M054287
  • GC19M054290
  • GC19M054306

Summaries for LILRA6 Gene

GeneCards Summary for LILRA6 Gene

LILRA6 (Leukocyte Immunoglobulin Like Receptor A6) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Osteoclast differentiation. An important paralog of this gene is LILRB3.

UniProtKB/Swiss-Prot for LILRA6 Gene

  • May act as receptor for class I MHC antigens.

Additional gene information for LILRA6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA6 Gene

Genomics for LILRA6 Gene

Regulatory Elements for LILRA6 Gene

Enhancers for LILRA6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H054199 1.9 FANTOM5 ENCODE dbSUPER 22.4 +37.1 37081 12.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D PRPF31 CNOT3 LENG8 LENG8-AS1 ZNF525 LILRB5 ZNF845 ZNF765 ENSG00000235681 RPS9
GH19H054282 1.3 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -40.2 -40159 1.1 KLF1 POLR2A IKZF1 LILRB3 LAIR1 LILRA6 LILRB5 ENSG00000249189 OSCAR MYADM LILRB2 VSTM1 LILRB1
GH19H054318 1.3 FANTOM5 Ensembl ENCODE 13.4 -76.3 -76310 1 RNF2 CEBPG ATF2 IKZF1 TARDBP EED NBN ATF7 IKZF2 CREM LILRB2 LILRB3 LAIR1 LILRA6 TTYH1 ENSG00000227407 LILRB5 ENSG00000249189 CNOT3 ENSG00000237017
GH19H054186 1.4 ENCODE dbSUPER 11.6 +53.2 53170 6.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PRPF31 ZNF665 LENG8 LENG8-AS1 CNOT3 ZNF845 ZNF525 ZNF677 ENSG00000269001 ENSG00000269288
GH19H054247 1.1 Ensembl ENCODE dbSUPER 8.9 -5.2 -5204 1.6 BCOR SMARCA5 ZMYM3 ZKSCAN1 NR2F2 POLR2A EED ETV6 LILRA6 LILRA4 GC19M054323 ENSG00000249189
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LILRA6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LILRA6 Gene

Genomic Locations for LILRA6 Gene
6,200 bases
Minus strand

Genomic View for LILRA6 Gene

Genes around LILRA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA6 Gene

Proteins for LILRA6 Gene

  • Protein details for LILRA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 6
    Protein Accession:

    Protein attributes for LILRA6 Gene

    481 amino acids
    Molecular mass:
    52399 Da
    Quaternary structure:
    No Data Available
    • Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

    Alternative splice isoforms for LILRA6 Gene


neXtProt entry for LILRA6 Gene

Post-translational modifications for LILRA6 Gene

  • Glycosylation at posLast=139139, posLast=280280, isoforms=301, and isoforms=340
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA6 Gene

No data available for DME Specific Peptides for LILRA6 Gene

Domains & Families for LILRA6 Gene

Gene Families for LILRA6 Gene

Suggested Antigen Peptide Sequences for LILRA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LILRA6: view

No data available for UniProtKB/Swiss-Prot for LILRA6 Gene

Function for LILRA6 Gene

Molecular function for LILRA6 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.

Phenotypes From GWAS Catalog for LILRA6 Gene

Phenotypes for LILRA6 Gene

GenomeRNAi human phenotypes for LILRA6:
genes like me logo Genes that share phenotypes with LILRA6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LILRA6 Gene

Localization for LILRA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA6 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LILRA6 Gene

Pathways & Interactions for LILRA6 Gene

genes like me logo Genes that share pathways with LILRA6: view

Pathways by source for LILRA6 Gene

Gene Ontology (GO) - Biological Process for LILRA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LILRA6: view

No data available for SIGNOR curated interactions for LILRA6 Gene

Drugs & Compounds for LILRA6 Gene

No Compound Related Data Available

Transcripts for LILRA6 Gene

mRNA/cDNA for LILRA6 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA6 Gene

No ASD Table

Relevant External Links for LILRA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRA6 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA6 Gene

This gene is overexpressed in Whole Blood (x38.4) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for LILRA6 Gene

This gene is overexpressed in Monocytes (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRA6 Gene

Protein tissue co-expression partners for LILRA6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LILRA6 Gene:


Evidence on tissue expression from TISSUES for LILRA6 Gene

  • Blood(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with LILRA6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA6 Gene

Orthologs for LILRA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRA6 33
  • 93.56 (n)
  • 64 (a)
(Rattus norvegicus)
Mammalia Lilra3 33
  • 68.27 (n)
(Bos Taurus)
Mammalia -- 34
  • 67 (a)
  • 60 (a)
-- 34
  • 59 (a)
-- 34
  • 55 (a)
-- 34
  • 54 (a)
-- 34
  • 51 (a)
-- 34
  • 50 (a)
-- 34
  • 49 (a)
-- 34
  • 42 (a)
-- 34
  • 36 (a)
-- 34
  • 27 (a)
(Canis familiaris)
Mammalia -- 34
  • 46 (a)
-- 34
  • 43 (a)
(Mus musculus)
Mammalia Gm15448 34
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 20 (a)
Species where no ortholog for LILRA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA6 Gene

Gene Tree for LILRA6 (if available)
Gene Tree for LILRA6 (if available)

Paralogs for LILRA6 Gene Pseudogenes for LILRA6 Gene

genes like me logo Genes that share paralogs with LILRA6: view

Variants for LILRA6 Gene

Sequence variations from dbSNP and Humsavar for LILRA6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1052966 --
rs1052975 --
rs620207 --
rs8104206 --

Structural Variations from Database of Genomic Variants (DGV) for LILRA6 Gene

Variant ID Type Subtype PubMed ID
nsv978848 CNV duplication 23825009
nsv9752 CNV gain+loss 18304495
nsv960942 OTHER complex 23825009
nsv953615 CNV deletion 24416366
nsv817870 CNV gain 17921354
nsv817869 CNV loss 17921354
nsv817868 CNV gain+loss 17921354
nsv580227 CNV loss 21841781
nsv580193 CNV gain 21841781
nsv580192 CNV gain+loss 21841781
nsv580191 CNV gain 21841781
nsv580150 CNV loss 21841781
nsv580149 CNV gain 21841781
nsv580148 CNV loss 21841781
nsv517129 CNV gain+loss 19592680
nsv513760 CNV insertion 21212237
nsv510774 CNV deletion 20534489
nsv498906 CNV loss 21111241
nsv458783 CNV loss 19166990
nsv442773 CNV gain+loss 18776908
nsv433322 CNV loss 18776910
nsv433320 CNV loss 18776910
nsv428371 CNV gain+loss 18775914
nsv2548 CNV insertion 18451855
nsv2546 CNV deletion 18451855
nsv183 CNV deletion 15895083
nsv1160663 OTHER complex 26073780
nsv1151876 CNV duplication 26484159
nsv1142120 CNV deletion 24896259
nsv1132481 CNV duplication 24896259
nsv1131442 CNV deletion 24896259
nsv1115551 CNV duplication 24896259
nsv1066425 CNV gain 25217958
nsv1061096 CNV gain+loss 25217958
nsv1060193 CNV gain 25217958
nsv1057076 CNV loss 25217958
esv6034 CNV loss 19470904
esv3893247 CNV loss 25118596
esv3644786 CNV loss 21293372
esv3584744 CNV loss 24956385
esv3574853 CNV gain 25503493
esv3390177 CNV duplication 20981092
esv32835 CNV gain 17666407
esv2763032 CNV gain+loss 21179565
esv2760520 CNV gain+loss 21179565
esv2758771 CNV gain+loss 17122850
esv2756707 CNV loss 18971310
esv2718860 CNV deletion 23290073
esv2718859 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv2663554 CNV deletion 23128226
esv2421809 OTHER complex 20811451
esv23225 CNV gain+loss 19812545
esv1006598 CNV insertion 20482838
esv1003658 CNV gain 20482838
dgv77e180 CNV gain 20482838
dgv671e214 CNV gain 21293372
dgv6555n54 CNV gain 21841781
dgv6551n54 CNV loss 21841781
dgv6549n54 CNV gain 21841781
dgv6548n54 CNV gain 21841781
dgv598n67 CNV gain 20364138
dgv434n27 CNV gain 19166990
dgv433n27 CNV loss 19166990
dgv432n27 CNV loss 19166990
dgv3660n100 CNV gain 25217958
dgv3659n100 CNV gain+loss 25217958
dgv3658n100 CNV gain+loss 25217958
dgv3657n100 CNV gain 25217958
dgv3656n100 CNV gain 25217958
dgv3655n100 CNV gain 25217958
dgv3654n100 CNV gain 25217958
dgv2026e59 CNV duplication 20981092
dgv1075e212 CNV gain 25503493
dgv1074e212 CNV gain 25503493
dgv1073e212 CNV loss 25503493
dgv1072e212 CNV gain 25503493

Variation tolerance for LILRA6 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.93; 89.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA6 Gene

Disorders for LILRA6 Gene

Relevant External Links for LILRA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LILRA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA6 Gene

Publications for LILRA6 Gene

  1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H … Ziegler A (Immunogenetics 2000) 2 3 4 60
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 45 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for LILRA6 Gene

Sources for LILRA6 Gene

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