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Aliases for LILRA5 Gene

Aliases for LILRA5 Gene

  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 2 3
  • Leukocyte Immunoglobulin-Like Receptor 9 3 4
  • CD85 Antigen-Like Family Member F 3 4
  • LILRB7 3 4
  • ILT-11 3 4
  • ILT11 3 4
  • LIR-9 3 4
  • LIR9 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 7 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 Soluble 3
  • Immunoglobulin-Like Transcript 11 Protein 3
  • Immunoglobulin-Like Transcript 11 4
  • Leukocyte Ig-Like Receptor 9 3
  • CD85f Antigen 4
  • CD85F 3
  • CD85 3

External Ids for LILRA5 Gene

Previous HGNC Symbols for LILRA5 Gene

  • LILRB7

Previous GeneCards Identifiers for LILRA5 Gene

  • GC19M059511
  • GC19M054818
  • GC19M051140

Summaries for LILRA5 Gene

Entrez Gene Summary for LILRA5 Gene

  • The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRA5 Gene

LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRA5 Gene

  • May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA5 Gene

Genomics for LILRA5 Gene

Regulatory Elements for LILRA5 Gene

Genomic Location for LILRA5 Gene

Chromosome:
19
Start:
54,307,070 bp from pter
End:
54,313,139 bp from pter
Size:
6,070 bases
Orientation:
Minus strand

Genomic View for LILRA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LILRA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA5 Gene

Proteins for LILRA5 Gene

  • Protein details for LILRA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI73-LIRA5_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 5
    Protein Accession:
    A6NI73
    Secondary Accessions:
    • A6NHI3

    Protein attributes for LILRA5 Gene

    Size:
    299 amino acids
    Molecular mass:
    32755 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LILRA5 Gene

    Alternative splice isoforms for LILRA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA5 Gene

Proteomics data for LILRA5 Gene at MOPED

Post-translational modifications for LILRA5 Gene

  • Glycosylation at Asn 43, Asn 157, Asn 242, and Asn 248
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA5 Gene

Antibody Products

  • R&D Systems Antibodies for LILRA5 (LILRA5/CD85f)

No data available for DME Specific Peptides for LILRA5 Gene

Domains & Families for LILRA5 Gene

Protein Domains for LILRA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LILRA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NI73

UniProtKB/Swiss-Prot:

LIRA5_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA5: view

Function for LILRA5 Gene

Molecular function for LILRA5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

Gene Ontology (GO) - Molecular Function for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LILRA5: view

Phenotypes for LILRA5 Gene

genes like me logo Genes that share phenotypes with LILRA5: view

Animal Model Products

miRNA for LILRA5 Gene

miRTarBase miRNAs that target LILRA5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LILRA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA5 Gene

Localization for LILRA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA5 Gene

Isoform 1: Membrane; Single-pass type I membrane protein. Secreted.
Isoform 2: Membrane; Single-pass type I membrane protein. Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.

Gene Ontology (GO) - Cellular Components for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LILRA5: view

No data available for Subcellular locations from COMPARTMENTS for LILRA5 Gene

Pathways & Interactions for LILRA5 Gene

genes like me logo Genes that share pathways with LILRA5: view

Pathways by source for LILRA5 Gene

Interacting Proteins for LILRA5 Gene

Selected Interacting proteins: A6NI73-LIRA5_HUMAN for LILRA5 Gene via I2D

Symbol External ID(s) Details
PTPN6

Gene Ontology (GO) - Biological Process for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with LILRA5: view

No data available for SIGNOR curated interactions for LILRA5 Gene

Drugs & Compounds for LILRA5 Gene

No Compound Related Data Available

Transcripts for LILRA5 Gene

mRNA/cDNA for LILRA5 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA5 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LILRA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for LILRA5 Gene

GeneLoc Exon Structure for
LILRA5
ECgene alternative splicing isoforms for
LILRA5

Expression for LILRA5 Gene

mRNA expression in normal human tissues for LILRA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA5 Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for LILRA5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.2) and Monocytes (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA5 Gene



SOURCE GeneReport for Unigene cluster for LILRA5 Gene Hs.710986

mRNA Expression by UniProt/SwissProt for LILRA5 Gene

A6NI73-LIRA5_HUMAN
Tissue specificity: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level).
genes like me logo Genes that share expression patterns with LILRA5: view

Protein tissue co-expression partners for LILRA5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LILRA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA5 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LILRA5 35
  • 73.65 (n)
  • 55.72 (a)
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Lilra5 35
  • 69.18 (n)
  • 57.19 (a)
Lilra5 16
Gp49a 36
  • 38 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LILRA5 35
  • 98.33 (n)
  • 96.66 (a)
LILRA5 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lilra5 35
  • 71.6 (n)
  • 58.48 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
LILRA4 36
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 11 (a)
OneToMany
Species with no ortholog for LILRA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA5 Gene

ENSEMBL:
Gene Tree for LILRA5 (if available)
TreeFam:
Gene Tree for LILRA5 (if available)

Paralogs for LILRA5 Gene

genes like me logo Genes that share paralogs with LILRA5: view

Variants for LILRA5 Gene

Sequence variations from dbSNP and Humsavar for LILRA5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4806743 -- 54,309,292(+) acccc(A/G)tctct intron-variant
rs10559466 -- 1(+) AAGAA(-/TAAT)TAAAG intron-variant
rs59260538 -- 1(+) GTTGA(-/TTTC)TTTCT upstream-variant-2KB
rs199822634 -- 1(+) AATAA(A/T)TAAAG intron-variant
rs201969470 -- 1(+) TTAAG(-/AAT)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LILRA5 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
nsv912402 CNV Gain 21882294
esv2718860 CNV Deletion 23290073
nsv833878 CNV Loss 17160897
nsv527908 CNV Gain 19592680
nsv510775 CNV Loss 20534489

Variation tolerance for LILRA5 Gene

Residual Variation Intolerance Score: 55.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRA5 Gene

HapMap Linkage Disequilibrium report
LILRA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA5 Gene

Disorders for LILRA5 Gene

Relevant External Links for LILRA5

Genetic Association Database (GAD)
LILRA5
Human Genome Epidemiology (HuGE) Navigator
LILRA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRA5
genes like me logo Genes that share disorders with LILRA5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA5 Gene

Publications for LILRA5 Gene

  1. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. (PMID: 12393390) Borges L. … Kuhlman T. (Blood 2003) 23 67
  2. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 67
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 67
  5. Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. (PMID: 19658091) Jones D.C. … Young N.T. (Eur. J. Immunol. 2009) 67

Products for LILRA5 Gene

Sources for LILRA5 Gene

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