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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LILRA5 Gene

protein-coding   GIFtS: 48
GCID: GC19M054818

leukocyte immunoglobulin-like receptor, subfamily A (with...


(Previous symbol: LILRB7)
 Explore 2 diseases affiliated with
LILRA5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LILRA5    

Aliases
for LILRA5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member
51 2
     CD85F2 5
ILT111 2 3 5     CD85f1
LIR91 2 3 5     Immunoglobulin-Like Transcript 11 Protein2
LILRB71 2 3     Leukocyte Ig-Like Receptor 92
CD851 2     Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 52
Leukocyte Immunoglobulin-Like Receptor 92 3     Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 Soluble2
ILT-112 3     Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains),
Member 72
LIR-92 3     CD85f Antigen3
CD85 Antigen-Like Family Member F2 3     Immunoglobulin-Like Transcript 113

External Ids:    HGNC: 163091   Entrez Gene: 3535142   Ensembl: ENSG000001871167   OMIM: 6060475   UniProtKB: A6NI733   

Export aliases for LILRA5 gene to outside databases

Previous GC identifers: GC19M059511 GC19M051140


Summaries
for LILRA5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LILRA5:
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family
members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the
surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which
suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor
genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants
encoding distinct isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LIRA5_HUMAN, A6NI73
Function: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC
antigen recognition




Genomic Views
for LILRA5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LILRA5 gene promoter:
         HEN1   POU2F1   SREBP-1a   SREBP-1c   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LILRA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for LILRA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRA5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054818:  view genomic region     (about GC identifiers)

Start:
 54,818,353 bp from pter      End:
 54,824,409 bp from pter
Size:
 6,057 bases      Orientation:
 minus strand

Proteins
for LILRA5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LIRA5_HUMAN, A6NI73 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily A member 5 precursor  
Size: 299 amino acids; 32755 Da
Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein. Secreted
Subcellular location: Isoform 2: Membrane; Single-pass type I membrane protein. Secreted
Subcellular location: Isoform 3: Secreted
Subcellular location: Isoform 4: Secreted
1 PDB 3D structure from and Proteopedia for LILRA5:
2D3V (3D)    
Secondary accessions: A6NHI3
Alternative splicing: 4 isoforms:  A6NI73-1   A6NI73-2   A6NI73-3   A6NI73-4   

Explore the universe of human proteins at neXtProt for LILRA5: NX_A6NI73

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NI73

    • LILRA5 Protein expression data from MOPED and PaxDb:    About this image 
    LILRA5 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_067073.1  NP_870994.1  NP_871714.1  NP_871715.1  

    ENSEMBL proteins: 
     ENSP00000301219   ENSP00000302948   ENSP00000389499   ENSP00000404236  

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    Uscn Proteins for LILRA5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016021integral to membrane IEA--

    LILRA5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for LILRA5

    Protein Domains /
    Families
    for LILRA5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LILRA5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry A6NI73

    ProtoNet protein and cluster: A6NI73

    UniProtKB/Swiss-Prot: LIRA5_HUMAN, A6NI73
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for LILRA5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRA5_HUMAN, A6NI73
    Function: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC
    antigen recognition

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
         
    LILRA5 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Pathways & Interactions
    for LILRA5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LILRA5

    1 Interacting protein for LILRA5 (A6NI733) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293503I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response IEA--

    LILRA5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LILRA5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LILRA5
    Search CenterWatch for drugs/clinical trials and news about LILRA5 / LIRA5 

    Transcripts
    for LILRA5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LILRA5 gene (4 alternative transcripts): 
    NM_021250.2  NM_181879.2  NM_181985.2  NM_181986.2  

    Unigene Cluster for LILRA5:

    Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
    Hs.710986  [show with all ESTs]
    Unigene Representative Sequence: NM_021250
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301219(uc002qfe.3 uc002qff.3 uc010yev.2 uc010yew.2)
    ENST00000346508 ENST00000477720 ENST00000489504 ENST00000486742 ENST00000446712(uc002qfg.1 uc002qfh.1)
    ENST00000432233

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF212842.1 AF324830.1 AF499916.1 AF499917.1 AF499918.1 AF499919.1 EU915611.1 EU915612.1 

    7 DOTS entries:

    DT.100742828  DT.91833897  DT.99994654  DT.99994661  DT.92466940  DT.95091468  DT.121487202 

    8 AceView cDNA sequences:

    NM_181986 NM_181985 F18318 NM_181879 BF901857 AF499919 AF499917 NM_021250 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LILRA5    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                                                  -     -               
    SP2:                                -                 -     -               
    SP3:                                                                        
    SP4:                                -                                       


    ECgene alternative splicing isoforms for LILRA5

    Expression
    for LILRA5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LILRA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGGAGATA
    LILRA5 Expression
    About this image

    LILRA5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LILRA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LILRA5

    SOURCE GeneReport for Unigene cluster: Hs.710986

    UniProtKB/Swiss-Prot: LIRA5_HUMAN, A6NI73
    Tissue specificity: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node
    and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+
    monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level)

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    In Situ
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    Orthologs
    for LILRA5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LILRA5 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    --
    (see all 59)    		 --
    		 28(a)
    24(a)
    (see all 59)    		 many ↔ many
    many ↔ many
    (see all 59)    		 Un(51843257-51844123)
    Un(10797126-10797984)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 15(a)
    15(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343329.1(1231914-1234163)
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for LILRA5 (if available)
    TreeFam Gene Tree for LILRA5 (if available) 

    Paralogs
    for LILRA5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LILRA5 gene
    KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  KIR3DL12  OSCAR2  NCR12  
    LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  LILRA12  KIR3DL32  
    KIR2DL12  LILRB22  A1BG2  KIR2DL22  LILRA22  KIR3DL22  KIR2DL32  FCAR2  
    LILRB32  GP62  
    18/47 SIMAP similar genes for LILRA5 using alignment to 1 protein entry:     LIRA5_HUMAN(see all similar genes):
    LILRB3    LILRA4    LILRB4    LILRA6    LILRB5    LILRB1
    LILRA3    LILRA1    FLJ00275    LILRA2    LAIR2    LILRB2
    KIR2DL4    KIR-K36    KIR222    KIR412    KIR2DL3    1060P11.3

    LILRA5 for paralogs           About GeneDecksing



    Genomic Variants
    for LILRA5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/223 NCBI SNPs in LILRA5 are shown (see all 223)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1399375071,2
    		--54817865(+) GCATGC/TGCCTG 2 -- ds50010--------
    rs1428159611,2
    		--54817879(+) TCCCAA/GCTACT 2 -- ds50010--------
    rs38267521,2
    		C--54817965(+) tccagC/Tctggg 2 -- ds50010--------
    rs1396572981,2
    		--54817987(+) GACTCC/TGTCTC 2 -- ds50010--------
    rs17614501,2
    		C,F,H--54818035(-) ACCTCC/TTGTCT 2 -- ds500122Minor allele frequency- T:0.25NS EA NA 2544
    rs1850699171,2
    		--54818046(+) TAGGAA/CGCCAT 2 -- ds50010--------
    rs736179771,2
    		C--54818150(+) CTCAGT/CAAAGC 2 -- ds50012Minor allele frequency- C:0.03WA 120
    rs1427432231,2
    		--54818359(+) CCTCCA/GTGGAT 2 -- ut310--------
    rs1898310041,2
    		--54818484(+) ATTGCA/GCCACT 2 -- ut310--------
    rs1815639831,2
    		--54818568(+) AAAGAA/GAGAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LILRA5 (54818353 - 54824409 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for LILRA5
         2 CNVs: 4088 5116

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for LILRA5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LILRA5 for disorders           About GeneDecksing

    OMIM gene information: 606047    OMIM disorders: --

    2 diseases for LILRA5:    About MalaCards
    hepatitis c    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: LILRA5 (1 document)

    Export disorders for LILRA5 gene to outside databases

    Publications
    for LILRA5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LILRA5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with LILRA5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)1, 2, 3 Wende H.... Ziegler A. (2000)
    2. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. (PubMed id 12393390)1, 2, 9 Borges L.... Kuhlman T. (2003)
    3. Crystal structure of the human monocyte-activating receptor, 'Group 2' leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). (PubMed id 16675463)1, 2 Shiroishi M.... Maenaka K. (2006)
    4. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1 Mosbruger T.L....Thio C.L. (2010)
    5. Alternative mRNA splicing creates transcripts encodin g soluble proteins from most LILR genes. (PubMed id 19658091)1 Jones D.C....Young N.T. (2009)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    External Searches for LILRA5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing LILRA5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353514 HGNC: 16309 AceView: LIR9 Ensembl:ENSG00000187116 euGenes: HUgn353514
    ECgene: LILRA5 H-InvDB: LILRA5

    Other Databases showing LILRA5 gene

    (According to HUGE)
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    Specialized Databases showing LILRA5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LILRA5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LILRA5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LILRA5 gene:
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