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LILRA5 Gene

protein-coding   GIFtS: 50
GCID: GC19M054818

Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With...


(Previous symbol: LILRB7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain),
Member 51 2
     CD852
LILRB71 2 3     Immunoglobulin-Like Transcript 11 Protein2
ILT112 3 5     Leukocyte Ig-Like Receptor 92
LIR92 3 5     Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 52
Leukocyte Immunoglobulin-Like Receptor 92 3     Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 Soluble2
ILT-112 3     Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 72
LIR-92 3     CD85f Antigen3
CD85 Antigen-Like Family Member F2 3     Immunoglobulin-Like Transcript 113
CD85F2 5     

External Ids:    HGNC: 163091   Entrez Gene: 3535142   Ensembl: ENSG000001871167   OMIM: 6060475   UniProtKB: A6NI733   

Export aliases for LILRA5 gene to outside databases

Previous GC identifers: GC19M059511 GC19M051140


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LILRA5 Gene:
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR
family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor
protein on the surface of monocytes has been shown to induce calcium flux and secretion of several
proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This
gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four
alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for LILRA5 Gene:
LILRA5 (leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5) is a protein-coding gene. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: LIRA5_HUMAN, A6NI73
Function: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC
antigen recognition




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LILRA5 gene promoter:
         HEN1   POU2F1   SREBP-1a   SREBP-1c   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLILRA5 promoter sequence
   Search Chromatin IP Primers for LILRA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRA5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054818:  view genomic region     (about GC identifiers)

Start:
54,818,353 bp from pter      End:
54,824,409 bp from pter
Size:
6,057 bases      Orientation:
minus strand

3 alternative locations:
Chr19-,NW_003571055 288,421-294,484      Chr19-,NW_003571061 288,602-294,639      Chr19-,NW_003571054 288,498-294,554     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LIRA5_HUMAN, A6NI73 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily A member 5 precursor  
Size: 299 amino acids; 32755 Da
1 PDB 3D structure from and Proteopedia for LILRA5:
2D3V (3D)    
Secondary accessions: A6NHI3
Alternative splicing: 4 isoforms:  A6NI73-1   A6NI73-2   A6NI73-3   A6NI73-4   

Explore the universe of human proteins at neXtProt for LILRA5: NX_A6NI73

Explore proteomics data for LILRA5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn43, Asn157, Asn248
  • Modification sites at PhosphoSitePlus

  • See LILRA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_067073.1  NP_870994.1  NP_871714.1  NP_871715.1  

    ENSEMBL proteins: 
     ENSP00000301219   ENSP00000302948   ENSP00000389499   ENSP00000404236  

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    antibodies-online proteins for LILRA5 (4 products) 

     
    antibodies-online peptides for LILRA5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry A6NI73

    ProtoNet protein and cluster: A6NI73

    UniProtKB/Swiss-Prot: LIRA5_HUMAN, A6NI73
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with LILRA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRA5_HUMAN, A6NI73
    Function: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC
    antigen recognition

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LILRA5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LILRA5

    miRNA
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    miRTarBase miRNAs that target LILRA5:
    hsa-mir-335-5p (MIRT019221)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIRA5_HUMAN, A6NI73: Isoform 1: Membrane; Single-pass type I membrane protein. Secreted
    LIRA5_HUMAN, A6NI73: Isoform 2: Membrane; Single-pass type I membrane protein. Secreted
    LIRA5_HUMAN, A6NI73: Isoform 3: Secreted
    LIRA5_HUMAN, A6NI73: Isoform 4: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LILRA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LILRA5 About    
    See pathways by source

    SuperPathContained pathways About
    1Osteoclast differentiation
    Osteoclast differentiation


    Find genes that share SuperPaths with LILRA5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for LILRA5):
        Osteoclast differentiation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LILRA5
    Interactions:

        Search GeneGlobe Interaction Network for LILRA5

    1 Interacting protein for LILRA5 (A6NI733) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293503I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response IEA--

    Find genes that share ontologies with LILRA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LILRA5 (LIRA5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LILRA5 gene (4 alternative transcripts): 
    NM_021250.3  NM_181879.2  NM_181985.3  NM_181986.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301219(uc002qfe.3 uc002qff.3 uc010yev.2 uc010yew.2)
    ENST00000346508 ENST00000477720 ENST00000489504 ENST00000486742 ENST00000446712(uc002qfg.1 uc002qfh.1)
    ENST00000432233
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat LILRA5

    8 AceView cDNA sequences:

    NM_181986 NM_181985 NM_021250 NM_181879 AF499917 AF499919 BF901857 F18318 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LILRA5    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                                                  -     -               
    SP2:                                -                 -     -               
    SP3:                                                                        
    SP4:                                -                                       


    ECgene alternative splicing isoforms for LILRA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LILRA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGAGATA
    LILRA5 Expression
    About this image


    LILRA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Brain (Nervous System)
             Medulla Oblongata
    LILRA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LILRA5 Protein Expression

    UniProtKB/Swiss-Prot: LIRA5_HUMAN, A6NI73
    Tissue specificity: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph
    node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed
    in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LILRA5 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lilra51 , 5 leukocyte immunoglobulin-like receptor, subfamily A more1, 5 69.18(n)1
    57.19(a)1
      7 (2.45 cM)5
    2328011  NM_001081239.21  NP_001074708.21 
     42377545 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    11(a)
    1 → many
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for LILRA5 (if available)
    TreeFam Gene Tree for LILRA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LILRA5 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  IGSF12  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for LILRA5 using alignment to 1 protein entry:     LIRA5_HUMAN(see all similar genes):
    LILRB3    LILRA4    LILRA6    LILRB5    LILRB4    LILRB1
    LILRA3    LILRA1    FLJ00275    LILRA2    LAIR2    LILRB2
    KIR2DL4    KIR-K36    KIR222    KIR412    KIR2DL3    KIR3DL3

    Find genes that share paralogs with LILRA5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LILRA5 (see all 273)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399375071,2
    C--54817865(+) GCATGC/TGCCTG 2 -- ds50010--------
    rs1428159611,2
    --54817879(+) TCCCAA/GCTACT 2 -- ds50010--------
    rs38267521,2
    C--54817965(+) tccagC/Tctggg 2 -- ds50010--------
    rs1396572981,2
    --54817987(+) GACTCC/TGTCTC 2 -- ds50010--------
    rs17614501,2
    C,F,H--54818035(-) ACCTCC/TTGTCT 2 -- ds500122Minor allele frequency- T:0.25NS EA NA 2544
    rs1850699171,2
    --54818046(+) TAGGAA/CGCCAT 2 -- ds50010--------
    rs736179771,2
    C,F--54818150(+) CTCAGT/CAAAGC 2 -- ds50012Minor allele frequency- C:0.03WA 120
    rs1427432231,2
    C--54818359(+) CCTCCA/GTGGAT 2 -- ut310--------
    rs1898310041,2
    --54818484(+) ATTGCA/GCCACT 2 -- ut310--------
    rs1815639831,2
    --54818568(+) AAAGAA/GAGAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LILRA5 (54818353 - 54824409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for LILRA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718860CNV Deletion23290073
    esv2718812CNV Deletion23290073
    nsv510775CNV Loss20534489
    nsv833878CNV Loss17160897
    nsv527908CNV Gain19592680
    nsv912402CNV Gain21882294
    nsv428371CNV Gain+Loss18775914
    dgv1119e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606047    OMIM disorders: --


    Find genes that share disorders with LILRA5           About GenesLikeMe

    Genetic Association Database (GAD): LILRA5
    Human Genome Epidemiology (HuGE) Navigator: LILRA5 (1 document)

    Export disorders for LILRA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LILRA5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LILRA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PubMed id 10941842)1, 2, 3 Wende H.... Ziegler A. (Immunogenetics 2000)
    2. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. (PubMed id 12393390)1, 2, 9 Borges L.... Kuhlman T. (Blood 2003)
    3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    4. Crystal structure of the human monocyte-activating receptor, 'Group 2' leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). (PubMed id 16675463)1, 2 Shiroishi M.... Maenaka K. (J. Biol. Chem. 2006)
    5. Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. (PubMed id 19658091)1 Jones D.C....Young N.T. (Eur. J. Immunol. 2009)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 353514 HGNC: 16309 AceView: LIR9 Ensembl:ENSG00000187116 euGenes: HUgn353514
    ECgene: LILRA5 Kegg: 353514 H-InvDB: LILRA5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LILRA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LILRA5 gene:
    Search GeneIP for patents involving LILRA5

    GeneCards and IP:
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