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Aliases for LILRA5 Gene

Aliases for LILRA5 Gene

  • Leukocyte Immunoglobulin Like Receptor A5 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 2 3
  • Leukocyte Immunoglobulin-Like Receptor 9 3 4
  • CD85 Antigen-Like Family Member F 3 4
  • Leucocyte Ig-Like Receptor A5 2 3
  • LILRB7 3 4
  • ILT-11 3 4
  • ILT11 3 4
  • LIR-9 3 4
  • LIR9 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 7 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 Soluble 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 5 3
  • Immunoglobulin-Like Transcript 11 Protein 3
  • Immunoglobulin-Like Transcript 11 4
  • Leukocyte Ig-Like Receptor 9 3
  • CD85f Antigen 4
  • CD85F 3
  • CD85 3

External Ids for LILRA5 Gene

Previous HGNC Symbols for LILRA5 Gene

  • LILRB7

Previous GeneCards Identifiers for LILRA5 Gene

  • GC19M059511
  • GC19M054818
  • GC19M051140

Summaries for LILRA5 Gene

Entrez Gene Summary for LILRA5 Gene

  • The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRA5 Gene

LILRA5 (Leukocyte Immunoglobulin Like Receptor A5) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. An important paralog of this gene is LILRA6.

UniProtKB/Swiss-Prot for LILRA5 Gene

  • May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA5 Gene

Genomics for LILRA5 Gene

Regulatory Elements for LILRA5 Gene

Enhancers for LILRA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F054199 1 FANTOM5 ENCODE 12.7 +107.4 107429 12.1 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 LILRB5 PRPF31 RPS9 LILRB3 LILRA6 LILRA2 ZNF765 ZNF525 LILRA4 ENSG00000269288
GH19F054018 1 FANTOM5 Ensembl ENCODE 11.7 +292.0 292022 6.8 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A GTF3C2 ZNF302 ZNF143 SP5 JUNB LILRB3 ZNF845 ZNF525 ENSG00000235681 ENSG00000267265 LENG8-AS1 ZNF765 PRPF31 VSTM1 LILRA5
GH19F054373 0.8 FANTOM5 ENCODE 10.2 -61.8 -61779 2.7 PKNOX1 TBL1XR1 EBF1 RELA YY1 ZNF316 EED ZNF143 ETV6 NFE2 FCAR LAIR1 LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1 LILRA2
GH19F054670 1.1 FANTOM5 Ensembl 10.1 -358.0 -357963 1.0 TNNI3 DNAAF3 ENSG00000239137 KIR3DX1 LILRA5 LILRA1 LILRB1 LILRB2 LILRB3 LILRA2
GH19F054661 1.3 FANTOM5 ENCODE 9.8 -348.8 -348828 2.4 HDAC1 TBP ARNT WRNIP1 ZNF76 SIN3A GLI4 ZBTB40 ZNF335 GLIS2 FCAR LILRB4 LAIR1 KIR3DX1 LILRB2 KIR2DL3 LILRB1 LILRA5 LILRB3 LILRA1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LILRA5 on UCSC Golden Path with GeneCards custom track

Promoters for LILRA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001015876 439 201 SPI1

Genomic Location for LILRA5 Gene

Chromosome:
19
Start:
54,307,070 bp from pter
End:
54,313,139 bp from pter
Size:
6,070 bases
Orientation:
Minus strand

Genomic View for LILRA5 Gene

Genes around LILRA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA5 Gene

Proteins for LILRA5 Gene

  • Protein details for LILRA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI73-LIRA5_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 5
    Protein Accession:
    A6NI73
    Secondary Accessions:
    • A6NHI3

    Protein attributes for LILRA5 Gene

    Size:
    299 amino acids
    Molecular mass:
    32755 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LILRA5 Gene

    Alternative splice isoforms for LILRA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA5 Gene

Post-translational modifications for LILRA5 Gene

  • Glycosylation at Asn 43, Asn 157, Asn 242, and Asn 248
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA5 Gene

Antibody Products

  • R&D Systems Antibodies for LILRA5 (LILRA5/CD85f)
  • Abcam antibodies for LILRA5
  • Santa Cruz Biotechnology (SCBT) Antibodies for LILRA5

No data available for DME Specific Peptides for LILRA5 Gene

Domains & Families for LILRA5 Gene

Protein Domains for LILRA5 Gene

Suggested Antigen Peptide Sequences for LILRA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NI73

UniProtKB/Swiss-Prot:

LIRA5_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA5: view

Function for LILRA5 Gene

Molecular function for LILRA5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.
genes like me logo Genes that share phenotypes with LILRA5: view

Animal Model Products

miRNA for LILRA5 Gene

miRTarBase miRNAs that target LILRA5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA5 Gene

Localization for LILRA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA5 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LILRA5 Gene COMPARTMENTS Subcellular localization image for LILRA5 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LILRA5: view

Pathways & Interactions for LILRA5 Gene

genes like me logo Genes that share pathways with LILRA5: view

Pathways by source for LILRA5 Gene

Interacting Proteins for LILRA5 Gene

Selected Interacting proteins: A6NI73-LIRA5_HUMAN for LILRA5 Gene via IID

Gene Ontology (GO) - Biological Process for LILRA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with LILRA5: view

No data available for SIGNOR curated interactions for LILRA5 Gene

Transcripts for LILRA5 Gene

mRNA/cDNA for LILRA5 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA5 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for LILRA5 Gene

GeneLoc Exon Structure for
LILRA5
ECgene alternative splicing isoforms for
LILRA5

Expression for LILRA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LILRA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA5 Gene

This gene is overexpressed in Whole Blood (x48.5).

Protein differential expression in normal tissues from HIPED for LILRA5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.2) and Monocytes (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA5 Gene



Protein tissue co-expression partners for LILRA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LILRA5 Gene:

LILRA5

SOURCE GeneReport for Unigene cluster for LILRA5 Gene:

Hs.710986

mRNA Expression by UniProt/SwissProt for LILRA5 Gene:

A6NI73-LIRA5_HUMAN
Tissue specificity: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level).
genes like me logo Genes that share expression patterns with LILRA5: view

Primer Products

Orthologs for LILRA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRA5 34 35
  • 98.33 (n)
dog
(Canis familiaris)
Mammalia LILRA5 34
  • 73.65 (n)
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Lilra5 34
  • 71.6 (n)
mouse
(Mus musculus)
Mammalia Lilra5 34 16
  • 69.18 (n)
Gp49a 35
  • 38 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 51 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
LILRA4 35
  • 28 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 18 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 11 (a)
OneToMany
Species where no ortholog for LILRA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA5 Gene

ENSEMBL:
Gene Tree for LILRA5 (if available)
TreeFam:
Gene Tree for LILRA5 (if available)

Paralogs for LILRA5 Gene

Pseudogenes.org Pseudogenes for LILRA5 Gene

genes like me logo Genes that share paralogs with LILRA5: view

Variants for LILRA5 Gene

Sequence variations from dbSNP and Humsavar for LILRA5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2781752 -- 54,308,345(-) atata(C/T)acaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LILRA5 Gene

Variant ID Type Subtype PubMed ID
dgv3660n100 CNV gain 25217958
dgv3661n100 CNV gain+loss 25217958
dgv3662n100 CNV gain 25217958
dgv3663n100 CNV gain 25217958
dgv6549n54 CNV gain 21841781
esv2718812 CNV deletion 23290073
esv2718860 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv2763032 CNV gain+loss 21179565
esv3574853 CNV gain 25503493
esv3644796 CNV loss 21293372
esv3644797 CNV gain 21293372
nsv1148744 OTHER inversion 26484159
nsv428371 CNV gain+loss 18775914
nsv527908 CNV gain 19592680
nsv833878 CNV loss 17160897
nsv960872 CNV duplication 23825009

Variation tolerance for LILRA5 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA5 Gene

Disorders for LILRA5 Gene

Relevant External Links for LILRA5

Genetic Association Database (GAD)
LILRA5
Human Genome Epidemiology (HuGE) Navigator
LILRA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRA5

No disorders were found for LILRA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA5 Gene

Publications for LILRA5 Gene

  1. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. (PMID: 12393390) Borges L. … Kuhlman T. (Blood 2003) 3 4 22 64
  2. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 3 4 64
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  4. Crystal structure of the human monocyte-activating receptor, 'Group 2' leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). (PMID: 16675463) Shiroishi M. … Maenaka K. (J. Biol. Chem. 2006) 3 4 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for LILRA5 Gene

Sources for LILRA5 Gene

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