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Aliases for LILRA4 Gene

Aliases for LILRA4 Gene

  • Leukocyte Immunoglobulin Like Receptor A4 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4 2 3
  • CD85 Antigen-Like Family Member G 3 4
  • Immunoglobulin-Like Transcript 7 3 4
  • Leucocyte Ig-Like Receptor A4 2 3
  • ILT7 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain), Member 4 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 3
  • CD85g Antigen 4
  • CD85g 3
  • ILT-7 4

External Ids for LILRA4 Gene

Previous GeneCards Identifiers for LILRA4 Gene

  • GC19M059540
  • GC19M054844
  • GC19M051166

Summaries for LILRA4 Gene

Entrez Gene Summary for LILRA4 Gene

  • This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]

GeneCards Summary for LILRA4 Gene

LILRA4 (Leukocyte Immunoglobulin Like Receptor A4) is a Protein Coding gene. Diseases associated with LILRA4 include Blastic Plasmacytoid Dendritic Cell. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. An important paralog of this gene is LILRB3.

UniProtKB/Swiss-Prot for LILRA4 Gene

  • May act as receptor for class I MHC antigens.

Gene Wiki entry for LILRA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA4 Gene

Genomics for LILRA4 Gene

Regulatory Elements for LILRA4 Gene

Enhancers for LILRA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G054199 1.9 FANTOM5 ENCODE dbSUPER 15.1 +133.5 133459 12.1 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 LILRB5 RPS9 PRPF31 LILRB3 LILRA6 LILRA2 LILRA4 VSTM1 LILRA5 ENSG00000249189
GH19G054220 0.6 Ensembl 15.4 +116.5 116469 3.8 SMARCE1 MTA2 TAL1 TCF12 ARID1B NCOR1 EGR1 ID3 TRIM24 LILRA4 LILRB5 RPS9 LILRA6 LILRB3 ENSG00000224579
GH19G054247 1.1 Ensembl ENCODE dbSUPER 8.1 +91.2 91175 1.6 BCOR SMARCA5 ZMYM3 ZKSCAN1 NR2F2 POLR2A EED ETV6 FOS LILRA6 LILRA4 GC19M054312 ENSG00000249189
GH19G054339 0.9 Ensembl ENCODE 0.7 -0.7 -737 0.9 MTA2 BHLHE40 TAL1 EBF1 MCM7 TCF12 NFIC NCOR1 EED IKZF1 LOC284379 DNAAF3 LILRA4 GC19M054352
GH19G054345 1.3 Ensembl ENCODE dbSUPER 0.4 -6.9 -6937 1.0 TBL1XR1 WRNIP1 BMI1 YBX1 RELB ETV6 IKZF2 CREM CBFB USF2 GC19M054352 LILRA4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LILRA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LILRA4 Gene

Chromosome:
19
Start:
54,333,185 bp from pter
End:
54,339,169 bp from pter
Size:
5,985 bases
Orientation:
Minus strand

Genomic View for LILRA4 Gene

Genes around LILRA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA4 Gene

Proteins for LILRA4 Gene

  • Protein details for LILRA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59901-LIRA4_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 4
    Protein Accession:
    P59901
    Secondary Accessions:
    • Q32MC4

    Protein attributes for LILRA4 Gene

    Size:
    499 amino acids
    Molecular mass:
    55165 Da
    Quaternary structure:
    • Interacts with BST2.

    Alternative splice isoforms for LILRA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA4 Gene

Post-translational modifications for LILRA4 Gene

  • Glycosylation at isoforms=2138, isoforms=2239, isoforms=2279, and posLast=300300
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LILRA4 Gene

Domains & Families for LILRA4 Gene

Suggested Antigen Peptide Sequences for LILRA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LILRA4: view

No data available for UniProtKB/Swiss-Prot for LILRA4 Gene

Function for LILRA4 Gene

Molecular function for LILRA4 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens.

Gene Ontology (GO) - Molecular Function for LILRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19564354
genes like me logo Genes that share ontologies with LILRA4: view

Phenotypes for LILRA4 Gene

genes like me logo Genes that share phenotypes with LILRA4: view

Animal Model Products

CRISPR Products

miRNA for LILRA4 Gene

miRTarBase miRNAs that target LILRA4

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LILRA4 (LILRA4/CD85g/ILT7)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA4 Gene

Localization for LILRA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRA4 gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LILRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA4: view

Pathways & Interactions for LILRA4 Gene

genes like me logo Genes that share pathways with LILRA4: view

Pathways by source for LILRA4 Gene

Interacting Proteins for LILRA4 Gene

Gene Ontology (GO) - Biological Process for LILRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LILRA4: view

No data available for SIGNOR curated interactions for LILRA4 Gene

Drugs & Compounds for LILRA4 Gene

(1) Drugs for LILRA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LILRA4: view

Transcripts for LILRA4 Gene

mRNA/cDNA for LILRA4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA4 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LILRA4 (LILRA4/CD85g/ILT7)

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA4 Gene

No ASD Table

Relevant External Links for LILRA4 Gene

GeneLoc Exon Structure for
LILRA4
ECgene alternative splicing isoforms for
LILRA4

Expression for LILRA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LILRA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA4 Gene

This gene is overexpressed in Spleen (x15.0), Whole Blood (x13.3), and Brain - Spinal cord (cervical c-1) (x5.2).

Protein differential expression in normal tissues from HIPED for LILRA4 Gene

This gene is overexpressed in Nasal epithelium (40.6), Lavage (20.2), and Breast (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRA4 Gene



NURSA nuclear receptor signaling pathways regulating expression of LILRA4 Gene:

LILRA4

SOURCE GeneReport for Unigene cluster for LILRA4 Gene:

Hs.406708

Evidence on tissue expression from TISSUES for LILRA4 Gene

  • Spleen(4.7)
  • Pancreas(4.1)
  • Lymph node(2.5)
genes like me logo Genes that share expression patterns with LILRA4: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LILRA4 Gene

Orthologs for LILRA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRA4 34 35
  • 98.33 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 62 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
LILRA4 35
  • 55 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 43 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Lilra6 35
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 20 (a)
OneToMany
Species where no ortholog for LILRA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA4 Gene

ENSEMBL:
Gene Tree for LILRA4 (if available)
TreeFam:
Gene Tree for LILRA4 (if available)

Paralogs for LILRA4 Gene

Pseudogenes.org Pseudogenes for LILRA4 Gene

genes like me logo Genes that share paralogs with LILRA4: view

Variants for LILRA4 Gene

Sequence variations from dbSNP and Humsavar for LILRA4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000066853 -- 54,340,504(+) TTGGG(A/C)GGCCC upstream-variant-2KB
rs1000494182 -- 54,334,317(+) AGAGA(C/T)AGAAA intron-variant
rs1001091800 -- 54,337,205(+) CCCCA(A/C)CAGTC intron-variant
rs1002404506 -- 54,337,492(+) AGGAG(C/G/T)GGCTC reference, missense
rs1002604426 -- 54,332,699(+) TTCTG(G/T)ACTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LILRA4 Gene

Variant ID Type Subtype PubMed ID
dgv3660n100 CNV gain 25217958
dgv3661n100 CNV gain+loss 25217958
dgv3662n100 CNV gain 25217958
dgv3663n100 CNV gain 25217958
dgv6549n54 CNV gain 21841781
esv2758771 CNV gain+loss 17122850
esv2763032 CNV gain+loss 21179565
esv3583531 CNV loss 25503493
esv3644796 CNV loss 21293372
esv3644797 CNV gain 21293372
esv3644801 CNV loss 21293372
esv3644802 CNV loss 21293372
nsv1148744 OTHER inversion 26484159
nsv428371 CNV gain+loss 18775914
nsv527908 CNV gain 19592680
nsv580236 CNV loss 21841781
nsv833878 CNV loss 17160897

Variation tolerance for LILRA4 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA4 Gene

Disorders for LILRA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LILRA4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LILRA4

Genetic Association Database (GAD)
LILRA4
Human Genome Epidemiology (HuGE) Navigator
LILRA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRA4
genes like me logo Genes that share disorders with LILRA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LILRA4 Gene

Publications for LILRA4 Gene

  1. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. (PMID: 19564354) Cao W. … Liu Y.J. (J. Exp. Med. 2009) 3 4 22 64
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 4 22 64
  3. Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. (PMID: 20193018) Cao W. … Bover L. (Immunol. Rev. 2010) 3 22 64
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  5. Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells. (PMID: 19723650) Tsukamoto N. … Kawakami Y. (Clin. Cancer Res. 2009) 3 22 64

Products for LILRA4 Gene

Sources for LILRA4 Gene

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