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Aliases for LILRA4 Gene

Aliases for LILRA4 Gene

  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4 2 3
  • CD85 Antigen-Like Family Member G 3 4
  • Immunoglobulin-Like Transcript 7 3 4
  • ILT7 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain), Member 4 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 3
  • CD85g Antigen 4
  • CD85g 3
  • ILT-7 4

External Ids for LILRA4 Gene

Summaries for LILRA4 Gene

Entrez Gene Summary for LILRA4 Gene

  • This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]

GeneCards Summary for LILRA4 Gene

LILRA4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4) is a Protein Coding gene. Diseases associated with LILRA4 include blastic plasmacytoid dendritic cell. Among its related pathways are Osteoclast differentiation. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRA4 Gene

  • May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.

Gene Wiki entry for LILRA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA4 Gene

Genomics for LILRA4 Gene

Genomic Location for LILRA4 Gene

Start:
54,333,185 bp from pter
End:
54,339,150 bp from pter
Size:
5,966 bases
Orientation:
Minus strand

Genomic View for LILRA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LILRA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA4 Gene

Regulatory Elements for LILRA4 Gene

Proteins for LILRA4 Gene

  • Protein details for LILRA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59901-LIRA4_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 4
    Protein Accession:
    P59901
    Secondary Accessions:
    • Q32MC4

    Protein attributes for LILRA4 Gene

    Size:
    499 amino acids
    Molecular mass:
    55165 Da
    Quaternary structure:
    • Interacts with BST2.

    Alternative splice isoforms for LILRA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA4 Gene

Proteomics data for LILRA4 Gene at MOPED

Post-translational modifications for LILRA4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn138, Asn239, Asn279, and Asn300

Other Protein References for LILRA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LILRA4 Gene

Domains for LILRA4 Gene

Gene Families for LILRA4 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • LILR :Leukocyte immunoglobulin-like receptors

Protein Domains for LILRA4 Gene

UniProtKB/Swiss-Prot:

LIRA4_HUMAN
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.:
    • P59901
genes like me logo Genes that share domains with LILRA4: view

Function for LILRA4 Gene

Molecular function for LILRA4 Gene

UniProtKB/Swiss-Prot Function: May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.

Gene Ontology (GO) - Molecular Function for LILRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19564354
genes like me logo Genes that share ontologies with LILRA4: view

miRNA for LILRA4 Gene

miRTarBase miRNAs that target LILRA4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LILRA4 Gene

Localization for LILRA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LILRA4 Gene COMPARTMENTS Subcellular localization image for LILRA4 gene
Compartment Confidence
plasma membrane 3
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LILRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA4: view

Pathways for LILRA4 Gene

SuperPathways for LILRA4 Gene

Superpath Contained pathways
1 Osteoclast differentiation
genes like me logo Genes that share pathways with LILRA4: view

Pathways by source for LILRA4 Gene

1 KEGG pathway for LILRA4 Gene

Interacting Proteins for LILRA4 Gene

Selected Interacting proteins: P59901-LIRA4_HUMAN for LILRA4 Gene via I2D

Symbol External ID(s) Details
BST2

Gene Ontology (GO) - Biological Process for LILRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LILRA4: view

Compounds for LILRA4 Gene

(1) Novoseek inferred chemical compound relationships for LILRA4 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 16.3 2
genes like me logo Genes that share compounds with LILRA4: view

Transcripts for LILRA4 Gene

mRNA/cDNA for LILRA4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA4 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA4 Gene

No ASD Table

Relevant External Links for LILRA4 Gene

GeneLoc Exon Structure for
LILRA4
ECgene alternative splicing isoforms for
LILRA4

Expression for LILRA4 Gene

mRNA expression in normal human tissues for LILRA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA4 Gene

This gene is overexpressed in Spleen (15.0), Whole Blood (13.3), and Brain - Spinal cord (cervical c-1) (5.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LILRA4 Gene

SOURCE GeneReport for Unigene cluster for LILRA4 Gene Hs.406708

mRNA Expression by UniProt/SwissProt for LILRA4 Gene

P59901-LIRA4_HUMAN
Tissue specificity: Detected in eosinophils, neutrophils and monocytes.
genes like me logo Genes that share expressions with LILRA4: view

Orthologs for LILRA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRA4 36
  • 98.33 (n)
  • 97.6 (a)
LILRA4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 55 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
LILRA4 37
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 41 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Lilra6 37
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 20 (a)
OneToMany
Species with no ortholog for LILRA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA4 Gene

ENSEMBL:
Gene Tree for LILRA4 (if available)
TreeFam:
Gene Tree for LILRA4 (if available)

Paralogs for LILRA4 Gene

genes like me logo Genes that share paralogs with LILRA4: view

Variants for LILRA4 Gene

Sequence variations from dbSNP and Humsavar for LILRA4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1205322 -- 54,333,166(+) ACTTA(A/G)ATTTT downstream-variant-500B
rs2013485 -- 54,333,844(-) TGGGT(A/G)CCCTG intron-variant
rs2241385 -- 54,338,295(-) CTTGT(A/G)GGATA intron-variant
rs3745419 -- 54,336,819(+) CAGAG(A/T)GGACA intron-variant
rs6417165 -- 54,333,110(+) TGTAT(C/T)TCTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LILRA4 Gene

Variant ID Type Subtype PubMed ID
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
nsv833878 CNV Loss 17160897
nsv527908 CNV Gain 19592680
nsv912411 CNV Loss 21882294
nsv912412 CNV Gain 21882294

Relevant External Links for LILRA4 Gene

HapMap Linkage Disequilibrium report
LILRA4

Disorders for LILRA4 Gene

Relevant External Links for LILRA4

Genetic Association Database (GAD)
LILRA4
Human Genome Epidemiology (HuGE) Navigator
LILRA4
genes like me logo Genes that share disorders with LILRA4: view

No data available for UniProtKB/Swiss-Prot for LILRA4 Gene

Publications for LILRA4 Gene

  1. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 4 23
  2. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. (PMID: 19564354) Cao W. … Liu Y.J. (J. Exp. Med. 2009) 3 4 23
  3. Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells. (PMID: 19723650) Tsukamoto N. … Kawakami Y. (Clin. Cancer Res. 2009) 3 23
  4. Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. (PMID: 20193018) Cao W. … Bover L. (Immunol. Rev. 2010) 3 23
  5. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. (PMID: 10941842) Wende H. … Ziegler A. (Immunogenetics 2000) 2 3

Products for LILRA4 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate LILRA4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for LILRA4
    • Block miRNA regulation of LILRA4 using miScript Target Protectors

    Sources for LILRA4 Gene

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