Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LILRA4 Gene

Aliases for LILRA4 Gene

  • Leukocyte Immunoglobulin Like Receptor A4 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4 2 3 5
  • CD85 Antigen-Like Family Member G 3 4
  • Immunoglobulin-Like Transcript 7 3 4
  • Leucocyte Ig-Like Receptor A4 2 3
  • ILT7 3 4
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain), Member 4 3
  • CD85g Antigen 4
  • CD85g 3
  • ILT-7 4

External Ids for LILRA4 Gene

Previous GeneCards Identifiers for LILRA4 Gene

  • GC19M059540
  • GC19M054844
  • GC19M051166

Summaries for LILRA4 Gene

Entrez Gene Summary for LILRA4 Gene

  • This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]

GeneCards Summary for LILRA4 Gene

LILRA4 (Leukocyte Immunoglobulin Like Receptor A4) is a Protein Coding gene. Diseases associated with LILRA4 include Blastic Plasmacytoid Dendritic Cell. Among its related pathways are Immune System and Osteoclast differentiation. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRA4 Gene

  • May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.

Gene Wiki entry for LILRA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA4 Gene

Genomics for LILRA4 Gene

Regulatory Elements for LILRA4 Gene

Enhancers for LILRA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LILRA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LILRA4 Gene

54,333,185 bp from pter
54,339,169 bp from pter
5,985 bases
Minus strand

Genomic View for LILRA4 Gene

Genes around LILRA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA4 Gene

Proteins for LILRA4 Gene

  • Protein details for LILRA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 4
    Protein Accession:
    Secondary Accessions:
    • Q32MC4

    Protein attributes for LILRA4 Gene

    499 amino acids
    Molecular mass:
    55165 Da
    Quaternary structure:
    • Interacts with BST2.

    Alternative splice isoforms for LILRA4 Gene


neXtProt entry for LILRA4 Gene

Proteomics data for LILRA4 Gene at MOPED

Post-translational modifications for LILRA4 Gene

  • Glycosylation at Asn 138, Asn 239, Asn 279, and Asn 300
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LILRA4 (LILRA4/CD85g/ILT7)

No data available for DME Specific Peptides for LILRA4 Gene

Domains & Families for LILRA4 Gene

Protein Domains for LILRA4 Gene

Suggested Antigen Peptide Sequences for LILRA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA4: view

Function for LILRA4 Gene

Molecular function for LILRA4 Gene

UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.

Phenotypes for LILRA4 Gene

genes like me logo Genes that share phenotypes with LILRA4: view

Animal Model Products

CRISPR Products

miRNA for LILRA4 Gene

miRTarBase miRNAs that target LILRA4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA4 Gene

Localization for LILRA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LILRA4 Gene COMPARTMENTS Subcellular localization image for LILRA4 gene
Compartment Confidence
plasma membrane 3
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for LILRA4 Gene

Pathways & Interactions for LILRA4 Gene

genes like me logo Genes that share pathways with LILRA4: view

Pathways by source for LILRA4 Gene

Interacting Proteins for LILRA4 Gene

Selected Interacting proteins: P59901-LIRA4_HUMAN for LILRA4 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for LILRA4 Gene


No data available for SIGNOR curated interactions for LILRA4 Gene

Drugs & Compounds for LILRA4 Gene

(1) Drugs for LILRA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LILRA4: view

Transcripts for LILRA4 Gene

mRNA/cDNA for LILRA4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA4 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA4 Gene

No ASD Table

Relevant External Links for LILRA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRA4 Gene

mRNA expression in normal human tissues for LILRA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA4 Gene

This gene is overexpressed in Spleen (x15.0), Whole Blood (x13.3), and Brain - Spinal cord (cervical c-1) (x5.2).

Protein differential expression in normal tissues from HIPED for LILRA4 Gene

This gene is overexpressed in Nasal epithelium (40.6), Lavage (20.2), and Breast (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA4 Gene

SOURCE GeneReport for Unigene cluster for LILRA4 Gene Hs.406708

mRNA Expression by UniProt/SwissProt for LILRA4 Gene

Tissue specificity: Detected in eosinophils, neutrophils and monocytes.
genes like me logo Genes that share expression patterns with LILRA4: view

Primer Products

No data available for Protein tissue co-expression partners for LILRA4 Gene

Orthologs for LILRA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRA4 35
  • 98.33 (n)
  • 97.6 (a)
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
-- 36
  • 26 (a)
-- 36
  • 40 (a)
-- 36
  • 43 (a)
-- 36
  • 62 (a)
-- 36
  • 43 (a)
-- 36
  • 44 (a)
-- 36
  • 33 (a)
-- 36
  • 47 (a)
-- 36
  • 45 (a)
  • 55 (a)
(Canis familiaris)
Mammalia -- 36
  • 41 (a)
-- 36
  • 43 (a)
(Mus musculus)
Mammalia Lilra6 36
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
Species with no ortholog for LILRA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA4 Gene

Gene Tree for LILRA4 (if available)
Gene Tree for LILRA4 (if available)

Paralogs for LILRA4 Gene

genes like me logo Genes that share paralogs with LILRA4: view

Variants for LILRA4 Gene

Sequence variations from dbSNP and Humsavar for LILRA4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2241384 - 54,338,671(-) CCTAC(C/T)CAAAC reference, missense
rs10419832 - 54,338,128(+) CTCAA(C/T)CAGAG reference, missense
rs7256494 -- 54,338,210(+) GGCAG(C/G/T)GCGGA reference, synonymous-codon
rs7257994 -- 54,334,624(+) TAGAT(C/T)GGAAG intron-variant
rs12976217 -- 54,338,192(+) GAGGT(C/T)ACCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LILRA4 Gene

Variant ID Type Subtype PubMed ID
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
nsv833878 CNV Loss 17160897
nsv527908 CNV Gain 19592680
nsv912411 CNV Loss 21882294
nsv912412 CNV Gain 21882294

Variation tolerance for LILRA4 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LILRA4 Gene

Disorders for LILRA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LILRA4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
blastic plasmacytoid dendritic cell
  • blastic nk-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LILRA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LILRA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LILRA4 Gene

Publications for LILRA4 Gene

  1. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. (PMID: 19564354) Cao W. … Liu Y.J. (J. Exp. Med. 2009) 3 4 23 67
  2. Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. (PMID: 20193018) Cao W. … Bover L. (Immunol. Rev. 2010) 3 23
  3. Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells. (PMID: 19723650) Tsukamoto N. … Kawakami Y. (Clin. Cancer Res. 2009) 3 23
  4. Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. (PMID: 16735691) Cao W. … Liu Y.J. (J. Exp. Med. 2006) 3 23
  5. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 23

Products for LILRA4 Gene

Sources for LILRA4 Gene