Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LILRA3 Gene

Aliases for LILRA3 Gene

  • Leukocyte Immunoglobulin Like Receptor A3 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain), Member 3 2 3
  • Leukocyte Immunoglobulin-Like Receptor 4 3 4
  • Monocyte Inhibitory Receptor HM43/HM31 3 4
  • CD85 Antigen-Like Family Member E 3 4
  • Immunoglobulin-Like Transcript 6 3 4
  • Leucocyte Ig-Like Receptor A3 2 3
  • ILT-6 3 4
  • LIR-4 3 4
  • ILT6 3 4
  • LIR4 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 3
  • CD85e Antigen 4
  • CD85E 3
  • HM31 3
  • HM43 3

External Ids for LILRA3 Gene

Previous GeneCards Identifiers for LILRA3 Gene

  • GC19M055680
  • GC19M055224
  • GC19M059475
  • GC19M059491
  • GC19M054798
  • GC19Mj00270

Summaries for LILRA3 Gene

Entrez Gene Summary for LILRA3 Gene

  • This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]

GeneCards Summary for LILRA3 Gene

LILRA3 (Leukocyte Immunoglobulin Like Receptor A3) is a Protein Coding gene. Diseases associated with LILRA3 include Lethal Midline Granuloma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include receptor activity and antigen binding.

UniProtKB/Swiss-Prot for LILRA3 Gene

  • Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Gene Wiki entry for LILRA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA3 Gene

Genomics for LILRA3 Gene

Regulatory Elements for LILRA3 Gene

Enhancers for LILRA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F000283 0.9 ENCODE 0.8 -2.7 -2687 0.2 LILRA3 PLPP2
GH19F000288 1.2 FANTOM5 Ensembl ENCODE 0.4 -9.3 -9254 2.9 TBP SREBF2 SIN3A RCOR1 FOS ZNF263 SMARCC1 CEBPB USF2 SMARCB1 PLPP2 WASH5P GZMM MISP RNF126 C2CD4C LILRA3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LILRA3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LILRA3 gene promoter:

Genomic Location for LILRA3 Gene

Chromosome:
19
Start:
270,735 bp from pter
End:
280,849 bp from pter
Size:
10,115 bases
Orientation:
Minus strand

Genomic View for LILRA3 Gene

Genes around LILRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for LILRA3 Gene

Proteins for LILRA3 Gene

  • Protein details for LILRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6C8-LIRA3_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 3
    Protein Accession:
    Q8N6C8
    Secondary Accessions:
    • J3KPM2
    • O15469
    • O15470
    • O75016
    • Q8N151
    • Q8N154
    • Q8NHJ1
    • Q8NHJ2
    • Q8NHJ3
    • Q8NHJ4

    Protein attributes for LILRA3 Gene

    Size:
    439 amino acids
    Molecular mass:
    47472 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LILRA3 Gene

    Alternative splice isoforms for LILRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA3 Gene

Post-translational modifications for LILRA3 Gene

  • N-glycosylation is required for ligand binding.
  • Glycosylation at Asn 140, Asn 281, Asn 302, Asn 341, and Asn 431
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA3 Gene

REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LILRA3 (LILRA3/CD85e)
  • Abcam antibodies for LILRA3
  • Cloud-Clone Corp. Antibodies for LILRA3

No data available for DME Specific Peptides for LILRA3 Gene

Domains & Families for LILRA3 Gene

Suggested Antigen Peptide Sequences for LILRA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6C8

UniProtKB/Swiss-Prot:

LIRA3_HUMAN :
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA3: view

Function for LILRA3 Gene

Molecular function for LILRA3 Gene

GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily A,member 3,expressed on monocytes and B cells,secreted,acting potentially as a dominant negative soluble receptor that would suppress the function of other LIR molecules,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
UniProtKB/Swiss-Prot Function:
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Gene Ontology (GO) - Molecular Function for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 9151699
GO:0004872 receptor activity TAS 9151699
genes like me logo Genes that share ontologies with LILRA3: view
genes like me logo Genes that share phenotypes with LILRA3: view

Animal Model Products

miRNA for LILRA3 Gene

miRTarBase miRNAs that target LILRA3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA3 Gene

Localization for LILRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LILRA3 Gene COMPARTMENTS Subcellular localization image for LILRA3 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS 9151699
genes like me logo Genes that share ontologies with LILRA3: view

Pathways & Interactions for LILRA3 Gene

genes like me logo Genes that share pathways with LILRA3: view

Pathways by source for LILRA3 Gene

Interacting Proteins for LILRA3 Gene

Selected Interacting proteins: Q8N6C8-LIRA3_HUMAN for LILRA3 Gene via IID

Gene Ontology (GO) - Biological Process for LILRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006952 defense response TAS 9151699
GO:0007165 signal transduction TAS 9151699
genes like me logo Genes that share ontologies with LILRA3: view

No data available for SIGNOR curated interactions for LILRA3 Gene

Transcripts for LILRA3 Gene

Unigene Clusters for LILRA3 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA3 Gene

No ASD Table

Relevant External Links for LILRA3 Gene

GeneLoc Exon Structure for
LILRA3
ECgene alternative splicing isoforms for
LILRA3

Expression for LILRA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LILRA3 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA3 Gene

This gene is overexpressed in Whole Blood (x43.9) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for LILRA3 Gene

This gene is overexpressed in Serum (43.0), Monocytes (7.7), and Plasma (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA3 Gene



NURSA nuclear receptor signaling pathways regulating expression of LILRA3 Gene:

LILRA3

SOURCE GeneReport for Unigene cluster for LILRA3 Gene:

Hs.113277

mRNA Expression by UniProt/SwissProt for LILRA3 Gene:

Q8N6C8-LIRA3_HUMAN
Tissue specificity: Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
genes like me logo Genes that share expression patterns with LILRA3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for LILRA3 Gene

Orthologs for LILRA3 Gene

No data available for Orthologs and Evolution for LILRA3 Gene

Paralogs for LILRA3 Gene

No data available for Paralogs for LILRA3 Gene

Variants for LILRA3 Gene

Sequence variations from dbSNP and Humsavar for LILRA3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1128645 --
rs11574606 --
rs4473306 --
rs539365473 -- 54,295,822(+) TACAT(-/A)TTGAT downstream-variant-500B
rs6509862 --

Variation tolerance for LILRA3 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRA3 Gene

Human Gene Mutation Database (HGMD)
LILRA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LILRA3 Gene

Disorders for LILRA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LILRA3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lethal midline granuloma
  • malignant granuloma of face
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LILRA3

Genetic Association Database (GAD)
LILRA3
Human Genome Epidemiology (HuGE) Navigator
LILRA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRA3
genes like me logo Genes that share disorders with LILRA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LILRA3 Gene

Publications for LILRA3 Gene

  1. Association of immunoglobulin-like transcript 6 deficiency with SjAPgren's syndrome. (PMID: 19790059) Kabalak G. … Witte T. (Arthritis Rheum. 2009) 3 22 46 64
  2. Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls. (PMID: 12651072) WiA9niewski A. … KuA9nierczyk P. (Hum. Immunol. 2003) 3 22 46 64
  3. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L. … Cosman D. (J. Immunol. 1997) 2 3 4 64
  4. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PMID: 9278324) Arm J.P. … Austen K.F. (J. Immunol. 1997) 2 3 4 64
  5. Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein. (PMID: 24085305) Lee T.H. … Tedla N. (J. Biol. Chem. 2013) 3 4 64

Products for LILRA3 Gene

Sources for LILRA3 Gene

Content
Loading form....