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LILRA3 Gene

protein-coding   GIFtS: 56
GCID: GC19M054798

Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM
Domain), Member 31 2
     CD85 Antigen-Like Family Member E2 3
ILT62 3 5     HM432 5
LIR42 3 5     CD85E2
Immunoglobulin-Like Transcript 62 3     HM312
Leukocyte Immunoglobulin-Like Receptor 42 3     Leucocyte Immunoglobulin-Like Receptor2
Monocyte Inhibitory Receptor HM43/HM312 3     Leukocyte Immunoglobulin-Like Receptor A32
ILT-62 3     Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 32
LIR-42 3     CD85e Antigen3

External Ids:    HGNC: 66041   Entrez Gene: 110262   Ensembl: ENSG000001708667   OMIM: 6048185   UniProtKB: Q8N6C83   

Export aliases for LILRA3 gene to outside databases

Previous GC identifers: GC19M055680 GC19M055224 GC19M059475 GC19M059491


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LILRA3 Gene:
This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B
cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the
transmembrane region found in other members of this family. It acts as a soluble receptor for class I major
histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms
have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human
populations, with many individuals containing a deletion of this genomic region. (provided by RefSeq, Mar 2014)

GeneCards Summary for LILRA3 Gene:
LILRA3 (leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3) is a protein-coding gene. Diseases associated with LILRA3 include ascariasis, and trichuriasis. GO annotations related to this gene include antigen binding and receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8
Function: Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I
molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of
monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes

Gene Wiki entry for LILRA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the LILRA3 gene promoter:
         AML1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for LILRA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRA3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054798:  view genomic region     (about GC identifiers)

Start:
54,799,854 bp from pter      End:
54,809,952 bp from pter
Size:
10,099 bases      Orientation:
minus strand

3 alternative locations:
Chr19-,NW_003571054 270,739-275,150      Chr19-,NW_003571055 270,619-275,030      Chr19-,NW_003571061 270,994-275,405     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily A member 3 precursor  
Size: 439 amino acids; 47472 Da
1 PDB 3D structure from and Proteopedia for LILRA3:
3Q2C (3D)    
Secondary accessions: J3KPM2 O15469 O15470 O75016 Q8N151 Q8N154 Q8NHJ1 Q8NHJ2 Q8NHJ3 Q8NHJ4
Alternative splicing: 3 isoforms:  Q8N6C8-1   Q8N6C8-2   Q8N6C8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRA3: NX_Q8N6C8

Explore proteomics data for LILRA3 at MOPED

Post-translational modifications: 

  • N-glycosylation is required for ligand binding1
  • Glycosylation2 at Asn140, Asn281, Asn302, Asn341, Asn431

  • See LILRA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001166125.1  NP_006856.3  

    ENSEMBL proteins: 
     ENSP00000375624   ENSP00000251390   ENSP00000375625  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR016332 A1B_glyco/leuk_Ig-like_rcpt
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8N6C8

    ProtoNet protein and cluster: Q8N6C8

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    LILRA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRA3_HUMAN, Q8N6C8
    Function: Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I
    molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of
    monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes

         Genatlas biochemistry entry for LILRA3:
    leukocyte immunoglobulin-like receptor,subfamily A,member 3,expressed on monocytes and B cells,secreted,acting
    potentially as a dominant negative soluble receptor that would suppress the function of other LIR
    molecules,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS9151699
    GO:0004872receptor activity TAS9151699
    GO:0005515protein binding ----
         
    LILRA3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LILRA3
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    miRTarBase miRNAs that target LILRA3:
    hsa-mir-335-5p (MIRT018243)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIRA3_HUMAN, Q8N6C8: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    cytosol1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS9151699

    LILRA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LILRA3 About    
    See pathways by source

    SuperPathContained pathways About
    1Osteoclast differentiation
    Osteoclast differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for LILRA3):
        Osteoclast differentiation


    LILRA3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LILRA3
    Interactions:

        Search GeneGlobe Interaction Network for LILRA3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for LILRA3 (Q8N6C82, 3 ENSP000002513904) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    CPSF6Q166303I2D: score=1 
    USP46ENSP000004078184STRING: ENSP00000407818
    DDA1ENSP000003529284STRING: ENSP00000352928
    PTPN11ENSP000003409444STRING: ENSP00000340944
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0006952defense response TAS9151699
    GO:0007165signal transduction TAS9151699

    LILRA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LILRA3 (LIRA3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LILRA3 gene (2 alternative transcripts): 
    NM_001172654.2  NM_006865.4  

    Unigene Cluster for LILRA3:

    Leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
    Hs.113277  [show with all ESTs]
    Unigene Representative Sequence: NM_006865
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391744 ENST00000251390(uc002qfd.3 uc010erk.3) ENST00000391745


    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat LILRA3
      QuantiFast Probe-based Assays in human, mouse, rat LILRA3

    Additional mRNA sequence: 

    AF014923.1 AF014924.1 AF025527.1 BC028208.1 U91926.1 U91927.1 

    8 DOTS entries:

    DT.454891  DT.100814431  DT.75189743  DT.92466938  DT.100876154  DT.101982942  DT.121487035  DT.121487097 

    14 AceView cDNA sequences:

    BF903041 AF014924 AK124026 AI655471 AF014923 CD369952 AA770279 BI029427 
    AI678772 BX280714 AV661443 NM_006864 NM_006865 NM_024318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LILRA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LILRA3 Expression
    About this image

    LILRA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LILRA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113277

    UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8
    Tissue specificity: Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral
    blood monocytes and lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LILRA3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    19(a)
    1 → many
    GL343329.1(823590-844642)
            Species with no ortholog for LILRA3

    ENSEMBL Gene Tree for LILRA3 (if available)
    TreeFam Gene Tree for LILRA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LILRA3 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  LILRB22  A1BG2  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for LILRA3 using alignment to 4 protein entries:     LIRA3_HUMAN (see all proteins) (see all similar genes):
    LILRA1    LILRB1    LILRA2    MIR cl-10    LILRB2    LILRA6
    LILRB3    LILRA4    LILRB5    LILRA5    KIR-K36    FLJ00275
    KIR412    KIR-G1    KIR-K64    KIR-K9    KIR-K15    KIR-K3

    LILRA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LILRA3 (see all 369)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006552921,2
    Cuntested11(-) GGACTC/TCCTTG 2 G syn11Minor allele frequency- T:0.00EU 1189
    rs14761241,2
    C--1(-) GACCAG/CGTCAG 1 -- us2k16Minor allele frequency- C:0.12MN NA WA 464
    rs37646291,2
    C,F--1(-) CACCTT/CAATCC 1 -- us2k11Minor allele frequency- C:0.15WA 118
    rs37646311,2
    C,H--1(-) ACGTGA/CAGTAT 1 -- us2k13Minor allele frequency- C:0.00NS NA 120
    rs38296851,2
    C--1(-) TCAATA/GTCATG 1 -- us2k10--------
    rs65098621,2,,4
    C,F,A,H--1(-) CTGAGA/CGGCCT 2 R L mis1 ese39Minor allele frequency- C:0.25NS NA WA CSA EU 1617
    rs72504951,2
    C--1(-) AAAAAG/TAACCA 1 -- us2k1 trp32Minor allele frequency- T:0.19NA WA 120
    rs81003191,2
    C,F,H--1(-) CAGGGC/TTGGGC 1 -- int14Minor allele frequency- T:0.02NS NA 566
    rs104232441,2
    C--1(-) tcagcC/Ttccca 1 -- us2k10--------
    rs115746021,2
    C--1(+) TCAAAT/CATAAG 1 -- us2k1 tfbs33Minor allele frequency- C:0.03NA 44

    HapMap Linkage Disequilibrium report for LILRA3 (54799854 - 54809952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LILRA3 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv665e199CNV Deletion23128226
    esv2718864CNV Deletion23290073
    esv2718812CNV Deletion23290073
    nsv821486CNV Deletion20802225
    dgv664e199CNV Deletion23128226
    esv2718860CNV Deletion23290073
    esv991182CNV Deletion20482838
    nsv828635CNV Loss20364138
    nsv510775CNV Loss20534489
    esv998993CNV Loss20482838

    Human Gene Mutation Database (HGMD): LILRA3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LILRA3
    DNA2.0 Custom Variant and Variant Library Synthesis for LILRA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604818    OMIM disorders: --

    11 diseases for LILRA3:    
    About MalaCards
    ascariasis    trichuriasis    rheumatoid arthritis    hepatitis c virus
    multiple sclerosis    type 1 diabetes    hepatitis c    arthritis
    hepatitis    prostate cancer    prostatitis


    LILRA3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for LILRA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 22.8 2 17202177 (2)

    Genetic Association Database (GAD): LILRA3
    Human Genome Epidemiology (HuGE) Navigator: LILRA3 (8 documents)

    Export disorders for LILRA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LILRA3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with LILRA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PubMed id 9278324)1, 2, 3 Arm J.P.... Austen K.F. (J. Immunol. 1997)
    2. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2, 3 Borges L.... Cosman D. (J. Immunol. 1997)
    3. Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls. (PubMed id 12651072)1, 4, 9 WiA9niewski A....KuA9nierczyk P. (Hum. Immunol. 2003)
    4. Association of immunoglobulin-like transcript 6 deficiency with SjAPgren's syndrome. (PubMed id 19790059)1, 4, 9 Kabalak G....Witte T. (Arthritis Rheum. 2009)
    5. Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein. (PubMed id 24085305)1, 2 Lee T.H.... Tedla N. (J. Biol. Chem. 2013)
    6. LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence. (PubMed id 21559424)1, 2 Ryu M....Gao G.F. (PLoS ONE 2011)
    7. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    8. Multiple sclerosis associates with LILRA3 deletion in Spanish patients. (PubMed id 19421224)1, 4 OrdA^A+ez D....Vilches C. (Genes Immun. 2009)
    9. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PubMed id 19195718)1, 4 Bonetti A....Tienari P.J. (J. Neuroimmunol. 2009)
    10. Association of multiple sclerosis with ILT6 deficiency. (PubMed id 15815690)1, 4 Koch S....Witte T. (Genes Immun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11026 HGNC: 6604 AceView: LILRB3 Ensembl:ENSG00000170866 euGenes: HUgn11026
    ECgene: LILRA3 Kegg: 11026 H-InvDB: LILRA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LILRA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LILRA3 gene:
    Search GeneIP for patents involving LILRA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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