Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LILRA3 Gene

protein-coding   GIFtS: 54
GCID: GC19M054798

leukocyte immunoglobulin-like receptor, subfamily A (without...

 Explore 7 diseases affiliated with
LILRA3 via our new
 Human Malady Compendium 
Biological research products
for LILRA3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily A (Without TM Domain),
Member 31 2
     ILT-62 3
ILT61 2 3 5     CD85 Antigen-Like Family Member E2 3
LIR41 2 3 5     CD85e1
LIR-41 2 3     CD85E2
HM431 2 5     E31
HM311 2     Leucocyte Immunoglobulin-Like Receptor2
Immunoglobulin-Like Transcript 62 3     Leukocyte Immunoglobulin-Like Receptor A32
Leukocyte Immunoglobulin-Like Receptor 42 3     Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 32
Monocyte Inhibitory Receptor HM43/HM312 3     CD85e Antigen3

External Ids:    HGNC: 66041   Entrez Gene: 110262   Ensembl: ENSG000001708667   OMIM: 6048185   UniProtKB: Q8N6C83   

Export aliases for LILRA3 gene to outside databases

Previous GC identifers: GC19M055680 GC19M055224 GC19M059475 GC19M059491


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LILRA3:
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and
at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function
(see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor
tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may
initiate stimulatory cascades (see LILRA1, MIM 604810). One member of subfamily A (LILRA3) lacks a transmembrane
region and is presumed to be a soluble receptor (Borges et al., 1997 (PubMed 9548455)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8
Function: May act as soluble receptor for class I MHC antigens

Gene Wiki entry for LILRA3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LILRA3 gene promoter:
         AML1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for LILRA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRA3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054798:  view genomic region     (about GC identifiers)

Start:
54,799,854 bp from pter      End:
54,809,952 bp from pter
Size:
10,099 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily A member 3 precursor  
Size: 439 amino acids; 47472 Da
Subcellular location: Secreted (Probable)
1 PDB 3D structure from and Proteopedia for LILRA3:
3Q2C (3D)    
Secondary accessions: J3KPM2 O15469 O15470 O75016 Q8N151 Q8N154 Q8NHJ1 Q8NHJ2 Q8NHJ3 Q8NHJ4
Alternative splicing: 3 isoforms:  Q8N6C8-1   Q8N6C8-2   Q8N6C8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRA3: NX_Q8N6C8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N6C8

  • LILRA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001166125.1  NP_006856.3  

    ENSEMBL proteins: 
     ENSP00000251390   ENSP00000375624   ENSP00000375625  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: LILRA3
    OriGene Protein Over-expression Lysate (see all 2): LILRA3
    OriGene Custom Protein Services for LILRA3 
    GenScript Custom Purified and Recombinant Proteins Services for LILRA3
    Novus Biologicals LILRA3 Proteins
    Novus Biologicals LILRA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LILRA3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS9151699


    LILRA3 for ontologies           About GeneDecksing



    LILRA3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LILRA3 (ILT6/CD85e)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LILRA3 
    GenScript Custom Superior Antibodies Services for LILRA3
    Novus Biologicals LILRA3 Antibodies
    Search for Antibodies for LILRA3 at Abcam  
    Uscn Antibodies for LILRA3
    Search ThermoFisher Antibodies for LILRA3

    Assay Products for LILRA3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for LILRA3 (ILT6/CD85e)
    GenScript Custom Assay Services for LILRA3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for LILRA3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LILRA3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR016332 A1B_glyco/leuk_Ig-like_rcpt
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8N6C8

    ProtoNet protein and cluster: Q8N6C8

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8
    Function: May act as soluble receptor for class I MHC antigens

         Genatlas biochemistry entry for LILRA3:
    leukocyte immunoglobulin-like receptor,subfamily A,member 3,expressed on monocytes and B cells,secreted,acting
    potentially as a dominant negative soluble receptor that would suppress the function of other LIR molecules,related to
    the Fc alpha receptor and natural killed inhibitory receptor superfamily

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: LILRA3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LILRA3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LILRA3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LILRA3
    OriGene shRNA RFP: LILRA3
    OriGene siRNA: LILRA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LILRA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LILRA3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): LILRA3 (NM_006865)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LILRA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LILRA3
    Search LifeMap BioReagents cell lines for LILRA3

    In Situ Assay
    Products:
       

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for LILRA3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS9151699
    GO:0004872receptor activity TAS9151699


    LILRA3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Osteoclast differentiation
    Osteoclast differentiation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for LILRA3):
        Osteoclast differentiation


    LILRA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LILRA3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for LILRA3 (Q8N6C82, 3 ENSP000002513904) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    CPSF6Q166303I2D: score=1 
    USP46ENSP000004078184STRING: ENSP00000407818
    DDA1ENSP000003529284STRING: ENSP00000352928
    --Q9BWA23, 2MINT-67602 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS9151699
    GO:0007165signal transduction TAS9151699


    LILRA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LILRA3
    Search CenterWatch for drugs/clinical trials and news about LILRA3 / LIRA3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LILRA3 gene (2 alternative transcripts): 
    NM_001172654.1  NM_006865.3  

    Unigene Cluster for LILRA3:

    Leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
    Hs.113277  [show with all ESTs]
    Unigene Representative Sequence: NM_006865
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251390(uc002qfd.3 uc010erk.3) ENST00000391744 ENST00000391745


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: LILRA3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LILRA3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LILRA3
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LILRA3
    OriGene shRNA RFP: LILRA3
    OriGene siRNA: LILRA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LILRA3
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): LILRA3 (NM_006865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LILRA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LILRA3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LILRA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRA3

    Additional cDNA sequence: 

    AF014923.1 AF014924.1 AF025527.1 BC028208.1 U91926.1 U91927.1 

    8 DOTS entries:

    DT.454891  DT.100814431  DT.75189743  DT.92466938  DT.100876154  DT.101982942  DT.121487035  DT.121487097 

    14 AceView cDNA sequences:

    BF903041 AF014924 AK124026 AI678772 AV661443 BX280714 AI655471 CD369952 
    AA770279 BI029427 AF014923 NM_006865 NM_006864 NM_024318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LILRA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See LILRA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LILRA3

    SOURCE GeneReport for Unigene cluster: Hs.113277

    UniProtKB/Swiss-Prot: LIRA3_HUMAN, Q8N6C8
    Tissue specificity: Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood
    monocytes and lung

        SABiosciences Custom PCR Arrays for LILRA3
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LILRA3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LILRA3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRA3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRA3
    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for LILRA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LILRA3 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 59)
    --
    29(a)
    26(a)
    (see all 59)
    many ↔ many
    many ↔ many
    (see all 59)
    Un(51843257-51844123)
    Un(10797126-10797984)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    28(a)
    23(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343329.1(823590-844642)
    GL343329.1(1231914-1234163)


    ENSEMBL Gene Tree for LILRA3 (if available)
    TreeFam Gene Tree for LILRA3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LILRA3 gene
    KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  LILRA52  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRB52  LILRA12  KIR3DL32  
    KIR2DL12  LILRB22  A1BG2  KIR2DL22  LILRA22  KIR3DL22  KIR2DL32  FCAR2  
    LILRB32  GP62  
    18/55 SIMAP similar genes for LILRA3 using alignment to 4 protein entries:     LIRA3_HUMAN (see all proteins) (see all similar genes):
    LILRA1    LILRB1    LILRA2    MIR cl-10    LILRB2    LILRA6
    LILRB3    LILRA4    LILRB5    LILRA5    KIR-K36    FLJ00275
    KIR412    LILRB4    KIR-G1    KIR-K64    KIR-K9    KIR-K15

    LILRA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/292 NCBI SNPs in LILRA3 are shown (see all 292    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006552921,2
    Cother54803698(+) GGACTC/TCCTTG 4 G syn11Minor allele frequency- T:0.00EU 1189
    rs48065121,2
    A,--54799379(+) GCCGCA/GCCACC 2 -- int12Minor allele frequency- G:0.00NA 4
    rs1391461601,2
    --54799434(+) TTACCA/GTGTTG 2 -- int10--------
    rs48067401,2
    C,A,--54799525(+) CACTGC/TGCCTG 2 -- int14Minor allele frequency- T:0.08NA WA 242
    rs1853661181,2
    --54799571(+) CAAGTG/TAACTT 2 -- int10--------
    rs1430675401,2
    --54799590(+) TTACAC/TACATA 2 -- int10--------
    rs1172227541,2
    C,F,--54799598(+) ATATTC/AAAATG 2 -- int11Minor allele frequency- A:0.07EA 120
    rs106665011,2
    C,--54799650(+) TTAGA-/TATT  
            
    TATTT
    2 -- int10--------
    rs1474813171,2
    --54799660(+) TAAGAC/TGTAGT 2 -- int10--------
    rs114359871,2
    C,--54799691(+) GTGAG-/AAATAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for LILRA3 (54799854 - 54809952 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for LILRA3
         12 CNVs: 39241 4088 89314 61718 5116 35682 7219 35683 35684 30922 58892 67611
    Human Gene Mutation Database (HGMD): LILRA3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LILRA3
    DNA2.0 Custom Variant and Variant Library Synthesis for LILRA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    LILRA3 for disorders           About GeneDecksing

    OMIM gene information: 604818    OMIM disorders: --

    7 diseases for LILRA3:    About MalaCards
    rheumatoid arthritis    ascariasis    multiple sclerosis    trichuriasis
    hepatitis c    arthritis    hepatitis

    1 Novoseek disease relationship for LILRA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 22.8 2 17202177 (2)

    Genetic Association Database (GAD): LILRA3
    Human Genome Epidemiology (HuGE) Navigator: LILRA3 (8 documents)

    Export disorders for LILRA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LILRA3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with LILRA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2, 3 Borges L....Cosman D. (1997)
    2. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PubMed id 9278324)1, 2, 3 Arm J.P.... Austen K.F. (1997)
    3. Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls. (PubMed id 12651072)1, 4, 9 Wisniewski A....Kusnierczyk P. (2003)
    4. Association of multiple sclerosis with ILT6 deficiency. (PubMed id 15815690)1, 4 Koch S....Witte T. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3. (PubMed id 12750859)1, 2 Norman P.J.... Vaughan R.W. (2003)
    8. Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. (PubMed id 12121272)1, 4 Moodie S.J....Ciclitira P.J. (2002)
    9. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new sti mulatory and inhibitory pathways. (PubMed id 9079806)1, 2 Samaridis J. and Colonna M. (1997)
    10. Association of immunoglobulin-like transcript 6 defic iency with SjAPgren's syndrome. (PubMed id 19790059)1, 9 Kabalak G....Witte T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11026 HGNC: 6604 AceView: LILRB3 Ensembl:ENSG00000170866 euGenes: HUgn11026
    ECgene: LILRA3 Kegg: 11026 H-InvDB: LILRA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LILRA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LILRA3 gene:
    Search GeneIP for patents involving LILRA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for LILRA3 (ILT6/CD85e)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for LILRA3 (ILT6/CD85e)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for LILRA3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LILRA3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LILRA3  
     OriGene Protein Over-expression Lysate for LILRA3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for LILRA3   OriGene 3'-UTR Clone for LILRA3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for LILRA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LILRA3   OriGene Custom Protein Services for LILRA3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LILRA3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LILRA3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRA3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LILRA3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRA3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRA3
     GenScript Custom Purified and Recombinant Proteins Services for LILRA3 GenScript cDNA clones with any tag delivered in your preferred vector for LILRA3
     GenScript Custom Assay Services for LILRA3 GenScript Custom Superior Antibodies Services for LILRA3
     GenScript Custom overexpressing Cell Line Services for LILRA3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LILRA3 promoter
     Search Chromatin IP Primers for LILRA3
     RT2 qPCR Primer Assay in human, mouse / rat LILRA3
     Search GNC Networks for LILRA3
     SABiosciences Custom PCR Arrays for LILRA3
     Search Tocris compounds for LILRA3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LILRA3 antibodies
     LILRA3 proteins
     LILRA3 lysates
     Search for Antibodies for LILRA3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for LILRA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     LILRA3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for LILRA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for LILRA3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for LILRA3
     Browse SwitchGear Promoter luciferase reporter plasmids for LILRA3
     Search ThermoFisher Antibodies for LILRA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LILRA3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4