Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LILRA2 Gene

protein-coding   GIFtS: 57
GCID: GC19P055084

Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With...

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain),
Member 21 2
     CD85 Antigen-Like Family Member H2 3
ILT12 3 5     CD85H2
LIR72 3 5     Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 22
Immunoglobulin-Like Transcript 12 3     Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 Soluble2
Leukocyte Immunoglobulin-Like Receptor 72 3     ILT-13
LIR-72 3     CD85h Antigen3

External Ids:    HGNC: 66031   Entrez Gene: 110272   Ensembl: ENSG000002399987   OMIM: 6048125   UniProtKB: Q8N1493   

Export aliases for LILRA2 gene to outside databases

Previous GC identifers: GC19P055948 GC19P055509 GC19P059760 GC19P059777 GC19P051410


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LILRA2 Gene:
This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B
cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating
receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune
response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is
located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3.
(provided by RefSeq, Mar 2014)

GeneCards Summary for LILRA2 Gene:
LILRA2 (leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2) is a protein-coding gene. Diseases associated with LILRA2 include microscopic polyangiitis, and leprosy. GO annotations related to this gene include antigen binding and receptor activity. An important paralog of this gene is LILRB4.

UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149
Function: Does not bind class I MHC antigens

Gene Wiki entry for LILRA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NT_187693.1  NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LILRA2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLILRA2 promoter sequence
   Search Chromatin IP Primers for LILRA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRA2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055084:  view genomic region     (about GC identifiers)

Start:
55,084,387 bp from pter      End:
55,099,027 bp from pter
Size:
14,641 bases      Orientation:
plus strand

1 alternative location:
Chr19+,NW_003571060 478,674-492,444     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily A member 2 precursor  
Size: 483 amino acids; 52992 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for LILRA2:
2OTP (3D)    
Secondary accessions: O75020
Alternative splicing: 2 isoforms:  Q8N149-1   Q8N149-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRA2: NX_Q8N149

Explore proteomics data for LILRA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn64, Asn103, Asn138, Asn279, Asn300, Asn339, Asn429

  • See LILRA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001124389.2  NP_001277199.1  NP_001277200.1  NP_006857.2  

    ENSEMBL proteins: 
     ENSP00000388131   ENSP00000251377   ENSP00000251376   ENSP00000375617   ENSP00000375618  

    LILRA2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LILRA2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LILRA2
    GenScript Custom Purified and Recombinant Proteins Services for LILRA2
    Novus Biologicals LILRA2 Proteins
    Novus Biologicals LILRA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LILRA2

    LILRA2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LILRA2 (ILT1/CD85h)
    OriGene Antibodies for LILRA2
    OriGene Custom Antibody Services for LILRA2
    Novus Biologicals LILRA2 Antibodies
    Abcam antibodies for LILRA2
    Cloud-Clone Corp. Antibodies for LILRA2
    ThermoFisher Antibodies for LILRA2
    LSBio Antibodies in human, mouse, rat for LILRA2

    LILRA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LILRA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LILRA2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LILRA2
    Cloud-Clone Corp. CLIAs for LILRA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR016332 A1B_glyco/leuk_Ig-like_rcpt
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8N149

    ProtoNet protein and cluster: Q8N149

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    LILRA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRA2_HUMAN, Q8N149
    Function: Does not bind class I MHC antigens

         Genatlas biochemistry entry for LILRA2:
    leukocyte immunoglobulin-like receptor,subfamily A,with TM domain,member 3,activating receptor expressed on
    myeloid cell and subsets of lymphoid cells,related to the Fc alpha receptor and natural killed inhibitory
    receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS9548455
    GO:0004872receptor activity TAS9548455
    GO:0005515protein binding ----
         
    LILRA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LILRA2:
     Decreased viability  High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LILRA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LILRA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LILRA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LILRA2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LILRA2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LILRA2
    SwitchGear 3'UTR luciferase reporter plasmidLILRA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LILRA2
    Predesigned siRNA for gene silencing in human, mouse, rat LILRA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LILRA2

    Clone
    Products:
         
    OriGene clones in human, mouse for LILRA2 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LILRA2 (NM_006866)
    Sino Biological Human cDNA Clone for LILRA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LILRA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LILRA2
    Browse ESI BIO Cell Lines and PureStem Progenitors for LILRA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LIRA2_HUMAN, Q8N149: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    LILRA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LILRA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Osteoclast differentiation
    Osteoclast differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for LILRA2):
        Osteoclast differentiation


    LILRA2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LILRA2
    Interactions:

        Search GeneGlobe Interaction Network for LILRA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for LILRA2 (ENSP000002513774) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCGR2AENSP000002714504STRING: ENSP00000271450
    FCGR3AENSP000003569464STRING: ENSP00000356946
    FCGR3BENSP000002948004STRING: ENSP00000294800
    SYKENSP000003648984STRING: ENSP00000364898
    PTPN11ENSP000003409444STRING: ENSP00000340944
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0006952defense response TAS9548455
    GO:0007165signal transduction TAS9548455

    LILRA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LILRA2 (LIRA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LILRA2 gene (4 alternative transcripts): 
    NM_001130917.2  NM_001290270.1  NM_001290271.1  NM_006866.3  

    Unigene Cluster for LILRA2:

    Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
    Hs.655593  [show with all ESTs]
    Unigene Representative Sequence: AK310088
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495786 ENST00000439534(uc010yfg.1) ENST00000251377(uc010ern.3)
    ENST00000251376(uc002qgf.3 uc010ero.3) ENST00000391737 ENST00000472992
    ENST00000391738(uc002qgg.4 uc010yfe.1 uc010yff.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LILRA2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LILRA2
    SwitchGear 3'UTR luciferase reporter plasmidLILRA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LILRA2
    Predesigned siRNA for gene silencing in human, mouse, rat LILRA2
    Clone
    Products:
         
    OriGene clones in human, mouse for LILRA2 (see all 12)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LILRA2 (NM_006866)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LILRA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LILRA2
    OriGene qSTAR qPCR primer pairs in human, mouse for LILRA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LILRA2
      QuantiTect SYBR Green Assays in human, mouse, rat LILRA2
      QuantiFast Probe-based Assays in human, mouse, rat LILRA2

    Additional mRNA sequence: 

    AF025531.1 AF041034.1 AK130170.1 AK222651.1 AK310088.1 BC017412.1 BC027916.1 EU915609.1 
    EU915610.1 U70665.1 U82275.1 U82276.1 U82277.1 U82278.1 

    14 DOTS entries:

    DT.92466938  DT.92466952  DT.99928022  DT.100776321  DT.100876154  DT.40133678  DT.91968529  DT.92466955 
    DT.95362106  DT.121487655  DT.454891  DT.121487097  DT.75189743  DT.95132612 

    2 AceView cDNA sequences:

    BI837046 NM_006866 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LILRA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGTGGCTG
    LILRA2 Expression
    About this image


    LILRA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 10 entries
             Monocytes Peripheral Blood
             Peripheral Blood Monocytes (PB CD14+)   
             neutrophils   
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Monocytes (CD14+)   
    LILRA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LILRA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655593

    UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149
    Tissue specificity: Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic
    cells and natural killer (NK) cells

        Custom PCR Arrays for LILRA2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LILRA2
    OriGene qSTAR qPCR primer pairs in human, mouse for LILRA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LILRA2
    QuantiTect SYBR Green Assays in human, mouse, rat LILRA2
    QuantiFast Probe-based Assays in human, mouse, rat LILRA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for LILRA2 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    37(a)
    many ↔ many
    1(102996666-103000872)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    20(a)
    1 → many
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for LILRA2 (if available)
    TreeFam Gene Tree for LILRA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LILRA2 gene
    LILRB42  KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  
    OSCAR2  NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  
    KIR3DL32  LILRA12  KIR3DS12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for LILRA2 using alignment to 3 protein entries:     LIRA2_HUMAN (see all proteins) (see all similar genes):
    LILRA3    LILRA1    LILRB1    LILRB2    MIR cl-10    LILRB3
    LILRA6    LILRA4    p58    LILRB5    FLJ00275    KIR2DS
    KIR2DS2S3    KIR412    p140    LILRA5    KIR-K36    KIR-K78

    LILRA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LILRA2
    PGOHUM00000237839


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LILRA2 (see all 650)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18346991,2
    C,F,H--55083369(-) AGGTGC/TGTGGG 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1131764971,2
    C,F--55083542(+) GCAGAC/TGCCCA 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1417959601,2
    C--55083566(+) TGGATC/TGAATC 2 -- us2k10--------
    rs664664761,2
    C,F--55083590(+) CAGGGA/GAGGGG 2 -- us2k14Minor allele frequency- G:0.33NA WA CSA 6
    rs1381312571,2
    C--55083602(+) TGAGCA/GCTGAC 2 -- us2k10--------
    rs1426377561,2
    --55083676(+) GCCACA/CGCTTC 2 -- us2k10--------
    rs1438812721,2
    --55083723(+) GAGGAC/TGTGGG 2 -- us2k10--------
    rs1132300771,2
    C,F--55083841(+) GATGCG/ATCTCA 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs621333651,2
    C,F--55083879(+) GTGCCC/TGTGGC 2 -- us2k19Minor allele frequency- T:0.11NA WA CSA 251
    rs1410409501,2
    --55083960(+) TGAGTG/TGGGGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for LILRA2 (55084387 - 55099027 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LILRA2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    dgv17e196CNV Deletion17116639
    esv2519988CNV Deletion19546169
    esv2718872CNV Deletion23290073
    dgv16e196CNV Duplication17116639
    nsv470158CNV Loss18288195
    dgv435n27CNV Loss19166990
    esv7755CNV Loss19470904
    nsv522872CNV Loss19592680
    dgv4005n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LILRA2
    DNA2.0 Custom Variant and Variant Library Synthesis for LILRA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604812    OMIM disorders: --

    8 diseases for LILRA2:    
    About MalaCards
    microscopic polyangiitis    leprosy    hepatitis c virus    systemic lupus erythematosus
    hepatitis c    lupus erythematosus    hepatitis b    hepatitis

    1 disease from the University of Copenhagen DISEASES database for LILRA2:
    Leprosy

    LILRA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): LILRA2
    Human Genome Epidemiology (HuGE) Navigator: LILRA2 (4 documents)

    Export disorders for LILRA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LILRA2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with LILRA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2, 3 Borges L.... Cosman D. (J. Immunol. 1997)
    2. Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis. (PubMed id 18273033)1, 4, 9 Mamegano K....Tsuchiya N. (Genes Immun. 2008)
    3. Crystal structure of myeloid cell activating receptor leukocyte Ig- like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. (PubMed id 19230061)1, 2, 9 Chen Y.... Gao G.F. (J. Mol. Biol. 2009)
    4. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. (PubMed id 9079806)1, 3, 9 Samaridis J. and Colonna M. (Eur. J. Immunol. 1997)
    5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. (PubMed id 12529506)1, 9 Tedla N.... Arm J.P. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. Stability engineering, biophysical, and biological characterization of the myeloid activating receptor immunoglobulin-like transcript 1 (ILT1/LIR-7/LILRA2). (PubMed id 17920929)1, 9 Chen Y....Gao G.F. (Protein Expr. Purif. 2007)
    9. LILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytes. (PubMed id 22479404)1 Lu H.K....Tedla N. (PLoS ONE 2012)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11027 HGNC: 6603 AceView: LILRA2 Ensembl:ENSG00000239998 euGenes: HUgn11027
    ECgene: LILRA2 Kegg: 11027 H-InvDB: LILRA2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LILRA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LILRA2 gene:
    Search GeneIP for patents involving LILRA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for LILRA2 (ILT1/CD85h)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LILRA2   OriGene RNAi products in human, mouse, rat for LILRA2  
     OriGene qPCR primer pairs and template standards for LILRA2   OriGene Protein Over-expression Lysate for LILRA2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LILRA2  
     OriGene qSTAR qPCR primer pairs in human, mouse for LILRA2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LILRA2   OriGene Custom Protein Services for LILRA2  

     
     
     Block miRNA regulation of human, mouse, rat LILRA2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LILRA2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRA2 Predesigned siRNA for gene silencing in human, mouse, rat LILRA2
     QuantiFast Probe-based Assays in human, mouse, rat LILRA2 QuantiTect SYBR Green Assays in human, mouse, rat LILRA2
     Custom PCR Arrays for LILRA2 Search Chromatin IP Primers for LILRA2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LILRA2  Search GeneGlobe Interaction Network for LILRA2
     Regulatory tfbs in LILRA2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LILRA2 GenScript cDNA clones with any tag delivered in your preferred vector for LILRA2
     GenScript Custom Assay Services for LILRA2 GenScript Custom overexpressing Cell Line Services for LILRA2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LILRA2 (LIRA2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for LILRA2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LILRA2 antibodies
     LILRA2 proteins
     LILRA2 lysates
     Antibodies for LILRA2
     See all of Abcam's Antibodies, Kits and Proteins for LILRA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LILRA2
     Antibodies for LILRA2
     ELISAs for LILRA2
     CLIAs for LILRA2



     Browse ESI BIO Cell Lines and PureStem Progenitors for LILRA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRA2
     SwitchGear 3'UTR luciferase reporter plasmids for LILRA2
     SwitchGear Promoter luciferase reporter plasmids for LILRA2
     ThermoFisher Antibodies for LILRA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LILRA2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LILRA2
     LSBio Antibodies in human, mouse, rat for LILRA2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LILRA2 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4