LILRA2 Gene
protein-coding GIFtS: 54
GCID: GC19P055084
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leukocyte immunoglobulin-like receptor, subfamily A (with...
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Aliases
for LILRA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member21 2 | | CD85 Antigen-Like Family Member H2 3 | | ILT11 2 3 5 | | CD85h1 | | LIR71 2 3 5 | | CD85H2 | | LIR-71 2 3 | | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 22 | | Immunoglobulin-Like Transcript 12 3 | | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 Soluble2 | | Leukocyte Immunoglobulin-Like Receptor 72 3 | | CD85h Antigen3 | | ILT-12 3 | | |
Export aliases for LILRA2 gene to outside databasesPrevious GC identifers: GC19P055948 GC19P055509 GC19P059760 GC19P059777 GC19P051410 |
Summaries
for LILRA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LILRA2:
This gene encodes a member of the leukocyte Ig-like receptor (LIR) family of immunoreceptors that are expressedpredominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The LIRfamily comprises of activating (subfamily A) and inhibitory (subfamily B) cell-surface receptors. The LIR encoded bythis gene was shown to be an activating receptor for eosinophils that elicited the release of cytotoxic granuleproteins, de novo lipid mediator generation, and cytokine release through vesicular transport. Alternatively splicedtranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149Function: Does not bind class I MHC antigens
Gene Wiki entry for LILRA2
|
Genomic Views
for LILRA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LILRA2 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for LILRA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4LILRA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P055084: view genomic region
(about GC identifiers)
Start:
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55,084,387 bp from pter |
End:
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55,099,027 bp from pter |
Size:
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14,641 bases |
Orientation:
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plus strand |
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Proteins
for LILRA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149 (See
protein sequence)Recommended Name: Leukocyte immunoglobulin-like receptor subfamily A member 2 precursor Size: 483 amino acids; 52992 Da
Subunit: Homodimer
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from  and Proteopedia  for LILRA2:2OTP (3D)
Secondary accessions: O75020Alternative splicing: 2 isoforms: Q8N149-1 Q8N149-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for LILRA2: NX_Q8N149
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N149
LILRA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001124389.1 NP_006857.1
ENSEMBL proteins: ENSP00000388131 ENSP00000251377 ENSP00000251376 ENSP00000375617 ENSP00000375618
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
LILRA2 for ontologies About GeneDecksing
LILRA2 Antibody Products:
Assay Products for LILRA2: |
Protein
Domains /
Families
for LILRA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LILRA2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N149ProtoNet protein and cluster: Q8N149 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains |
Function
for LILRA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149Function: Does not bind class I MHC antigens Genatlas biochemistry entry for LILRA2:leukocyte immunoglobulin-like receptor,subfamily A,with TM domain,member 3,activating receptor expressed on myeloidcell and subsets of lymphoid cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
LILRA2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for LILRA2:
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Pathways & Interactions
for LILRA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Osteoclast differentiation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for LILRA2):
LILRA2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LILRA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for LILRA2 (ENSP000002513774) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
LILRA2 for ontologies About GeneDecksing
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Drugs & Compounds
for LILRA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LILRA2
Search CenterWatch for drugs/clinical trials and news about LILRA2 / LIRA2
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Transcripts
for LILRA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LILRA2 gene (2 alternative transcripts): NM_001130917.1 NM_006866.2 Unigene Cluster for LILRA2: Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 Hs.655593 [show with all ESTs]Unigene Representative Sequence: AK3100887 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495786 ENST00000439534(uc010yfg.1) ENST00000251377(uc010ern.3)
ENST00000251376(uc002qgf.3 uc010ero.3) ENST00000391737 ENST00000472992
ENST00000391738(uc002qgg.4 uc010yfe.1 uc010yff.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): LILRA2 (NM_006866) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LILRA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA2 |
Additional cDNA sequence: AF025531.1 AF041034.1 AK130170.1 AK222651.1 AK310088.1 BC017412.1 BC027916.1 EU915609.1 EU915610.1 U70665.1 U82275.1 U82276.1 U82277.1 U82278.1 12 DOTS entries: DT.92466938 DT.92466952 DT.99928022 DT.100776321 DT.100876154 DT.40133678 DT.91968529 DT.92466955 DT.95362106 DT.454891 DT.121487097 DT.75189743 2 AceView cDNA sequences: BI837046 NM_006866
GeneLoc Exon Structure
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Expression
for LILRA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LILRA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGTGGCTG
About this image
See LILRA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LILRA2
SOURCE GeneReport for Unigene cluster: Hs.655593
UniProtKB/Swiss-Prot: LIRA2_HUMAN, Q8N149Tissue specificity: Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cellsand natural killer (NK) cells
SABiosciences Custom PCR Arrays for LILRA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LILRA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LILRA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRA2 |
Orthologs
for LILRA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for LILRA2 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for LILRA2 (if available)
TreeFam Gene Tree for LILRA2 (if available) |
Paralogs
for LILRA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LILRA2 gene
- KIR2DL42 LILRB42 LILRB12 LILRA62 IGSF12 LILRA52 KIR3DL12 OSCAR2
- NCR12 LILRA42 ENSG000002177922 TARM12 KIR3DX12 LILRA32 LILRB52 KIR3DL32
- LILRA12 KIR2DL12 LILRB22 A1BG2 KIR2DL22 KIR3DL22 KIR2DL32 FCAR2
- LILRB32 GP62
18/57 SIMAP similar genes for LILRA2 using alignment to 3 protein entries: LIRA2_HUMAN (see all proteins)
(see all similar genes):LILRA3 LILRA1 LILRB1 LILRB2 MIR cl-10 LILRB3
LILRA6 LILRA4 p58 LILRB5 FLJ00275 KIR2DS
KIR412 p140 LILRA5 KIR-K36 KIR-K78 KIR-K39
LILRA2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for LILRA2
PGOHUM00000237839
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Genomic Variants
for LILRA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LILRA2 (55084387 - 55099027 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for LILRA2
7 CNVs: 102879 4088 30082 61720 5345 5447 53601 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LILRA2 |
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Disorders
/ Diseases
for LILRA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LILRA2 for disorders About GeneDecksing
OMIM gene information: 604812
OMIM disorders: --
7  diseases for LILRA2: About MalaCardsmicroscopic polyangiitis systemic lupus erythematosus lupus erythematosus hepatitis c
leprosy hepatitis b hepatitis
1 disease from the University of Copenhagen DISEASES database for LILRA2:Leprosy Human Genome Epidemiology (HuGE) Navigator: LILRA2 (4 documents)
Export disorders for LILRA2 gene to outside databases
|
Publications
for LILRA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LILRA2 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with LILRA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2, 3 Borges L....Cosman D. (1997)
- Crystal structure of myeloid cell activating receptor leukocyte Ig- like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. (PubMed id 19230061)1, 2, 9 Chen Y.... Gao G.F. (2009)
- Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new sti mulatory and inhibitory pathways. (PubMed id 9079806)1, 3, 9 Samaridis J. and Colonna M. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis. (PubMed id 18273033)1, 9 Mamegano K....Tsuchiya N. (2008)
- Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. (PubMed id 12529506)1, 9 Tedla N.... Arm J.P. (2003)
- LILRA2 selectively modulates LPS-mediated cytokine pro duction and inhibits phagocytosis by monocytes. (PubMed id 22479404)1 Lu H.K....Tedla N. (2012)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1 Mosbruger T.L....Thio C.L. (2010)
- Alternative mRNA splicing creates transcripts encodin g soluble proteins from most LILR genes. (PubMed id 19658091)1 Jones D.C....Young N.T. (2009)
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External Searches for LILRA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LILRA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LILRA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LILRA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LILRA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LILRA2 gene:
Search GeneIP for patents involving LILRA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LILRA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LILRA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LILRA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LILRA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRA2 |
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| | | |  |  |  | | | | ThermoFisher Antibodies for LILRA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA2 |
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