Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LILRA2 Gene

Aliases for LILRA2 Gene

  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 2 3
  • ILT1 3 4 6
  • LIR7 3 4 6
  • Leukocyte Immunoglobulin-Like Receptor 7 3 4
  • CD85 Antigen-Like Family Member H 3 4
  • Immunoglobulin-Like Transcript 1 3 4
  • LIR-7 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 Soluble 3
  • Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 3
  • CD85h Antigen 4
  • CD85H 3
  • ILT-1 4

External Ids for LILRA2 Gene

Previous GeneCards Identifiers for LILRA2 Gene

  • GC19P055948
  • GC19P055509
  • GC19P059760
  • GC19P059777
  • GC19P055084
  • GC19P051410

Summaries for LILRA2 Gene

Entrez Gene Summary for LILRA2 Gene

  • This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]

GeneCards Summary for LILRA2 Gene

LILRA2 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2) is a Protein Coding gene. Among its related pathways are Osteoclast differentiation. GO annotations related to this gene include receptor activity and antigen binding. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRA2 Gene

  • Does not bind class I MHC antigens.

Gene Wiki entry for LILRA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA2 Gene

Genomics for LILRA2 Gene

Regulatory Elements for LILRA2 Gene

Transcription factor binding sites by QIAGEN in the LILRA2 gene promoter:

Genomic Location for LILRA2 Gene

Start:
54,572,920 bp from pter
End:
54,587,560 bp from pter
Size:
14,641 bases
Orientation:
Plus strand

Genomic View for LILRA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LILRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA2 Gene

Proteins for LILRA2 Gene

  • Protein details for LILRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N149-LIRA2_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 2
    Protein Accession:
    Q8N149
    Secondary Accessions:
    • O75020

    Protein attributes for LILRA2 Gene

    Size:
    483 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for LILRA2 Gene

    Alternative splice isoforms for LILRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA2 Gene

Proteomics data for LILRA2 Gene at MOPED

Post-translational modifications for LILRA2 Gene

  • Glycosylation at Asn64, Asn103, Asn138, Asn279, Asn300, Asn339, and Asn429
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LILRA2 Gene

Domains for LILRA2 Gene

Gene Families for LILRA2 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • LILR :Leukocyte immunoglobulin-like receptors

Protein Domains for LILRA2 Gene

Suggested Antigen Peptide Sequences for LILRA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N149

UniProtKB/Swiss-Prot:

LIRA2_HUMAN :
  • Q8N149
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA2: view

Function for LILRA2 Gene

Molecular function for LILRA2 Gene

GENATLAS Biochemistry: leukocyte immunoglobulin-like receptor,subfamily A,with TM domain,member 3,activating receptor expressed on myeloid cell and subsets of lymphoid cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
UniProtKB/Swiss-Prot Function: Does not bind class I MHC antigens.

Gene Ontology (GO) - Molecular Function for LILRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 9548455
GO:0004872 receptor activity TAS 9548455
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LILRA2: view

Phenotypes for LILRA2 Gene

GenomeRNAi human phenotypes for LILRA2:
genes like me logo Genes that share phenotypes with LILRA2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LILRA2 Gene

Localization for LILRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA2 Gene

Membrane; Single-pass type I membrane protein.
Isoform 4: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LILRA2 Gene COMPARTMENTS Subcellular localization image for LILRA2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LILRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA2: view

Pathways for LILRA2 Gene

SuperPathways for LILRA2 Gene

Superpath Contained pathways
1 Osteoclast differentiation
genes like me logo Genes that share pathways with LILRA2: view

Pathways by source for LILRA2 Gene

1 KEGG pathway for LILRA2 Gene

Interacting Proteins for LILRA2 Gene

Gene Ontology (GO) - Biological Process for LILRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006952 defense response TAS 9548455
GO:0007165 signal transduction TAS 9548455
genes like me logo Genes that share ontologies with LILRA2: view

Transcripts for LILRA2 Gene

mRNA/cDNA for LILRA2 Gene

(14) Additional mRNA sequences :
(41) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA2 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LILRA2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA2 Gene

No ASD Table

Relevant External Links for LILRA2 Gene

GeneLoc Exon Structure for
LILRA2
ECgene alternative splicing isoforms for
LILRA2

Expression for LILRA2 Gene

mRNA expression in normal human tissues for LILRA2 Gene

mRNA differential expression in normal tissues according to GTEx for LILRA2 Gene

This gene is overexpressed in Whole Blood (42.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LILRA2 Gene

SOURCE GeneReport for Unigene cluster for LILRA2 Gene Hs.655593

mRNA Expression by UniProt/SwissProt for LILRA2 Gene

Q8N149-LIRA2_HUMAN
Tissue specificity: Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells.
genes like me logo Genes that share expressions with LILRA2: view

In Situ Assay Products

Orthologs for LILRA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRA2 35
  • 97.42 (n)
  • 95.71 (a)
LILRA2 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
OneToMany
Species with no ortholog for LILRA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA2 Gene

ENSEMBL:
Gene Tree for LILRA2 (if available)
TreeFam:
Gene Tree for LILRA2 (if available)

Paralogs for LILRA2 Gene

Pseudogenes.org Pseudogenes for LILRA2 Gene

genes like me logo Genes that share paralogs with LILRA2: view

Variants for LILRA2 Gene

Sequence variations from dbSNP and Humsavar for LILRA2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs272403 -- 54,580,202(+) TTTTT(C/T)TTTTT intron-variant
rs272404 -- 54,580,470(+) tcttg(C/T)gatag intron-variant
rs374188 -- 54,575,167(-) GTCTC(C/T)GGCCC intron-variant
rs435055 -- 54,575,055(-) CTCCA(A/G)GCAAT intron-variant
rs1052120 -- 54,575,308(+) GCCCC(C/T)GGGGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for LILRA2 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv4005n71 CNV Loss 21882294
nsv522872 CNV Loss 19592680
dgv435n27 CNV Loss 19166990
nsv470158 CNV Loss 18288195
esv7755 CNV Loss 19470904
dgv16e196 CNV Duplication 17116639
dgv17e196 CNV Deletion 17116639
esv2519988 CNV Deletion 19546169
nsv9759 CNV Gain 18304495

Relevant External Links for LILRA2 Gene

HapMap Linkage Disequilibrium report
LILRA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA2 Gene

Disorders for LILRA2 Gene

(1) University of Copenhagen DISEASES for LILRA2 Gene

Relevant External Links for LILRA2

Genetic Association Database (GAD)
LILRA2
Human Genome Epidemiology (HuGE) Navigator
LILRA2
genes like me logo Genes that share disorders with LILRA2: view

No data available for UniProtKB/Swiss-Prot for LILRA2 Gene

Publications for LILRA2 Gene

  1. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L. … Cosman D. (J. Immunol. 1997) 2 3 4
  2. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. (PMID: 9079806) Samaridis J. … Colonna M. (Eur. J. Immunol. 1997) 2 3 23
  3. Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis. (PMID: 18273033) Mamegano K. … Tsuchiya N. (Genes Immun. 2008) 3 23 48
  4. Crystal structure of myeloid cell activating receptor leukocyte Ig- like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. (PMID: 19230061) Chen Y. … Gao G.F. (J. Mol. Biol. 2009) 3 4 23
  5. Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. (PMID: 19658091) Jones D.C. … Young N.T. (Eur. J. Immunol. 2009) 3 4

Products for LILRA2 Gene

Sources for LILRA2 Gene

Back to Top

Content