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Aliases for LILRA1 Gene

Aliases for LILRA1 Gene

  • Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 1 2 3
  • Leukocyte Immunoglobulin-Like Receptor 6 3 4
  • CD85 Antigen-Like Family Member I 3 4
  • LIR-6 3 4
  • LIR6 3 4
  • CD85i Antigen 4
  • CD85I 3

External Ids for LILRA1 Gene

Previous GeneCards Identifiers for LILRA1 Gene

  • GC19P055968
  • GC19M055529
  • GC19P059781
  • GC19P059796
  • GC19P055105
  • GC19P051428

Summaries for LILRA1 Gene

Entrez Gene Summary for LILRA1 Gene

  • This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

GeneCards Summary for LILRA1 Gene

LILRA1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 1) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include transmembrane signaling receptor activity and antigen binding. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRA1 Gene

  • May act as receptor for class I MHC antigens

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRA1 Gene

Genomics for LILRA1 Gene

Regulatory Elements for LILRA1 Gene

Transcription factor binding sites by QIAGEN in the LILRA1 gene promoter:

Genomic Location for LILRA1 Gene

Chromosome:
19
Start:
54,573,879 bp from pter
End:
54,602,724 bp from pter
Size:
28,846 bases
Orientation:
Plus strand

Genomic View for LILRA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LILRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRA1 Gene

Proteins for LILRA1 Gene

  • Protein details for LILRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75019-LIRA1_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 1
    Protein Accession:
    O75019
    Secondary Accessions:
    • O75018
    • Q3MJA6

    Protein attributes for LILRA1 Gene

    Size:
    489 amino acids
    Molecular mass:
    53275 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LILRA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRA1 Gene

Proteomics data for LILRA1 Gene at MOPED

Post-translational modifications for LILRA1 Gene

  • Glycosylation at Asn 140, Asn 281, Asn 302, Asn 341, Asn 431, and Asn 448
  • Modification sites at PhosphoSitePlus

Other Protein References for LILRA1 Gene

Antibody Products

  • R&D Systems Antibodies for LILRA1 (LILRA1/CD85i/LIR-6)

No data available for DME Specific Peptides for LILRA1 Gene

Domains & Families for LILRA1 Gene

Protein Domains for LILRA1 Gene

Suggested Antigen Peptide Sequences for LILRA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75019

UniProtKB/Swiss-Prot:

LIRA1_HUMAN :
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRA1: view

Function for LILRA1 Gene

Molecular function for LILRA1 Gene

GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily A,member 1,predominantly expressed on monocytes and B cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,with two (and others ?) alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
May act as receptor for class I MHC antigens

Gene Ontology (GO) - Molecular Function for LILRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 9548455
GO:0004888 transmembrane signaling receptor activity TAS 9548455
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LILRA1: view
genes like me logo Genes that share phenotypes with LILRA1: view

Animal Model Products

CRISPR Products

miRNA for LILRA1 Gene

miRTarBase miRNAs that target LILRA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LILRA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LILRA1 Gene

Localization for LILRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRA1 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for LILRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LILRA1: view

No data available for Subcellular locations from COMPARTMENTS for LILRA1 Gene

Pathways & Interactions for LILRA1 Gene

genes like me logo Genes that share pathways with LILRA1: view

Pathways by source for LILRA1 Gene

Interacting Proteins for LILRA1 Gene

Gene Ontology (GO) - Biological Process for LILRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006952 defense response TAS 9548455
GO:0007166 cell surface receptor signaling pathway TAS 9548455
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with LILRA1: view

No data available for SIGNOR curated interactions for LILRA1 Gene

Drugs & Compounds for LILRA1 Gene

No Compound Related Data Available

Transcripts for LILRA1 Gene

mRNA/cDNA for LILRA1 Gene

(27) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRA1 Gene

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LILRA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRA1 Gene

No ASD Table

Relevant External Links for LILRA1 Gene

GeneLoc Exon Structure for
LILRA1
ECgene alternative splicing isoforms for
LILRA1

Expression for LILRA1 Gene

mRNA expression in normal human tissues for LILRA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRA1 Gene

This gene is overexpressed in Whole Blood (x33.5) and Spleen (x7.3).

Protein differential expression in normal tissues from HIPED for LILRA1 Gene

This gene is overexpressed in Nasal epithelium (54.3) and Serum (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LILRA1 Gene



SOURCE GeneReport for Unigene cluster for LILRA1 Gene Hs.710507

mRNA Expression by UniProt/SwissProt for LILRA1 Gene

O75019-LIRA1_HUMAN
Tissue specificity: Detected in monocytes and B-cells.
genes like me logo Genes that share expression patterns with LILRA1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein tissue co-expression partners for LILRA1 Gene

Orthologs for LILRA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRA3 35
  • 91.03 (n)
  • 84.37 (a)
LILRA6 36
  • 68 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 33 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
OneToMany
Species with no ortholog for LILRA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRA1 Gene

ENSEMBL:
Gene Tree for LILRA1 (if available)
TreeFam:
Gene Tree for LILRA1 (if available)

Paralogs for LILRA1 Gene

genes like me logo Genes that share paralogs with LILRA1: view

Variants for LILRA1 Gene

Sequence variations from dbSNP and Humsavar for LILRA1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1808514 -- 54,601,435(-) atgac(A/C)atgtg utr-variant-3-prime, nc-transcript-variant
rs1808515 -- 54,601,393(-) GATCT(A/G)AGGAG utr-variant-3-prime, nc-transcript-variant
rs2363862 -- 54,600,274(+) ATCCT(C/G)AGCTC intron-variant, utr-variant-3-prime
rs7251559 -- 54,603,131(+) ATATC(A/G)TACAA downstream-variant-500B
rs8101951 -- 54,596,724(+) tagcc(A/G)agcgt intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LILRA1 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
dgv4005n71 CNV Loss 21882294
nsv522872 CNV Loss 19592680
dgv435n27 CNV Loss 19166990
nsv470158 CNV Loss 18288195
esv7755 CNV Loss 19470904
dgv16e196 CNV Duplication 17116639
dgv17e196 CNV Deletion 17116639
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
nsv516569 CNV Gain+Loss 19592680

Variation tolerance for LILRA1 Gene

Residual Variation Intolerance Score: 98.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.32; 90.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRA1 Gene

HapMap Linkage Disequilibrium report
LILRA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRA1 Gene

Disorders for LILRA1 Gene

Relevant External Links for LILRA1

Genetic Association Database (GAD)
LILRA1
Human Genome Epidemiology (HuGE) Navigator
LILRA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRA1
genes like me logo Genes that share disorders with LILRA1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRA1 Gene

Publications for LILRA1 Gene

  1. Crystal structure of myeloid cell activating receptor leukocyte Ig- like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. (PMID: 19230061) Chen Y. … Gao G.F. (J. Mol. Biol. 2009) 23 67
  2. Killer cell Ig-like receptor and leukocyte Ig-like receptor transgenic mice exhibit tissue- and cell-specific transgene expression. (PMID: 12960331) Belkin D. … Trowsdale J. (J. Immunol. 2003) 23 67
  3. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PMID: 10941837) Liu W.R. … Arm J.P. (Immunogenetics 2000) 23 67
  4. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PMID: 9548455) Borges L. … Cosman D. (J. Immunol. 1997) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for LILRA1 Gene

Sources for LILRA1 Gene

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