LILRA1 Gene
protein-coding GIFtS: 53
GCID: GC19P055105
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leukocyte immunoglobulin-like receptor, subfamily A (with...
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Aliases
for LILRA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member11 2 | | CD85i1 | | LIR61 2 3 5 | | CD85I2 | | LIR-61 2 3 | | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 12 | | Leukocyte Immunoglobulin-Like Receptor 62 3 | | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 1 Soluble Isoform2 | | CD85 Antigen-Like Family Member I2 3 | | CD85i Antigen3 |
Export aliases for LILRA1 gene to outside databasesPrevious GC identifers: GC19P055968 GC19M055529 GC19P059781 GC19P059796 GC19P051428 |
Summaries
for LILRA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LIRA1_HUMAN, O75019Function: May act as receptor for class I MHC antigens
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Genomic Views
for LILRA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LILRA1 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for LILRA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4LILRA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P055105: view genomic region
(about GC identifiers)
Start:
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55,105,047 bp from pter |
End:
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55,113,555 bp from pter |
Size:
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8,509 bases |
Orientation:
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plus strand |
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Proteins
for LILRA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LIRA1_HUMAN, O75019 (See
protein sequence)Recommended Name: Leukocyte immunoglobulin-like receptor subfamily A member 1 precursor Size: 489 amino acids; 53275 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O75018 Q3MJA6Alternative splicing: 2 isoforms: O75019-1 O75019-2 Explore the universe of human proteins at neXtProt for LILRA1: NX_O75019
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75019
LILRA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006854.1
ENSEMBL proteins: ENSP00000251372 ENSP00000413715 Reactome Protein details: O75019
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
LILRA1 for ontologies About GeneDecksing
LILRA1 Antibody Products:
Assay Products for LILRA1: |
Protein
Domains /
Families
for LILRA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LILRA1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75019ProtoNet protein and cluster: O75019 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: LIRA1_HUMAN, O75019Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains |
Function
for LILRA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LIRA1_HUMAN, O75019Function: May act as receptor for class I MHC antigens Genatlas biochemistry entry for LILRA1:leukocyte immunoglobulin-like receptor,subfamily A,member 1,predominantly expressed on monocytes and B cells,related tothe Fc alpha receptor and natural killed inhibitory receptor superfamily,with two (and others ?) alternatively splicedisoforms
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for LILRA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
LILRA1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for LILRA1:
|
Pathways & Interactions
for LILRA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Osteoclast differentiation | | | 3 | Cleavage of Alpha-1-Microglobulin | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for LILRA1
1 
Kegg Pathway (Kegg details for LILRA1):
LILRA1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LILRA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for LILRA1 (ENSP000002513724) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
LILRA1 for ontologies About GeneDecksing
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Drugs & Compounds
for LILRA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LILRA1
Search CenterWatch for drugs/clinical trials and news about LILRA1 / LIRA1
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Transcripts
for LILRA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LILRA1 gene: NM_006863.2 Unigene Cluster for LILRA1: Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 Hs.710507 [show with all ESTs]Unigene Representative Sequence: NM_0068635 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000473156 ENST00000495417 ENST00000251372(uc002qgh.1) ENST00000477255(uc010yfh.2)
ENST00000453777
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LILRA1 (NM_006863) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LILRA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA1 |
Additional cDNA sequence: AF025529.1 AF025530.1 AK290919.1 AK310122.1 AK311226.1 BC032238.1 BC047007.1 BC063009.1 BC093708.1 BC101514.1 EU915602.1 22 DOTS entries: DT.121487523 DT.121487584 DT.91739845 DT.92415976 DT.101982942 DT.100876154 DT.121487301 DT.40122109 DT.95086241 DT.121487488 DT.121643114 DT.95118369 DT.121487135 DT.121487341 DT.121487705 DT.40133678 DT.95132612 DT.100776321 DT.121487202 DT.121645424 DT.75189743 DT.95346153 1 AceView cDNA sequence: NM_006863
GeneLoc Exon Structure
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Expression
for LILRA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LILRA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAACTCACT
About this image
See LILRA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LILRA1
SOURCE GeneReport for Unigene cluster: Hs.710507
UniProtKB/Swiss-Prot: LIRA1_HUMAN, O75019Tissue specificity: Detected in monocytes and B-cells
SABiosciences Custom PCR Arrays for LILRA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LILRA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LILRA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRA1 |
Orthologs
for LILRA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for LILRA1 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for LILRA1 (if available)
TreeFam Gene Tree for LILRA1 (if available) |
Paralogs
for LILRA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LILRA1 gene
- KIR2DL42 LILRB42 LILRB12 LILRA62 IGSF12 LILRA52 KIR3DL12 OSCAR2
- NCR12 LILRA42 ENSG000002177922 TARM12 KIR3DX12 LILRA32 LILRB52 KIR3DL32
- KIR2DL12 LILRB22 A1BG2 KIR2DL22 LILRA22 KIR3DL22 KIR2DL32 FCAR2
- GP62 LILRB32
18/31 SIMAP similar genes for LILRA1 using alignment to 1 protein entry: LIRA1_HUMAN(see all similar genes):LILRA3 LILRB2 MIR cl-10 LILRA2 LILRB1 LILRA4
LILRB3 LILRA6 LILRB5 KIR2DL3 LILRA5 KIR2DS4
1060P11.7 KIR2DS2 KIR2DL1 KIR3DL3 1060P11.3 KIR2DS3
LILRA1 for paralogs About GeneDecksing
|
Genomic Variants
for LILRA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LILRA1 (55105047 - 55113555 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for LILRA1
6 CNVs: 4088 30082 61720 5345 5447 53601 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LILRA1 |
|
Disorders
/ Diseases
for LILRA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LILRA1 for disorders About GeneDecksing
OMIM gene information: 604810
OMIM disorders: --
3  diseases for LILRA1: About MalaCardshepatitis c hepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: LILRA1 (4 documents)
Export disorders for LILRA1 gene to outside databases
|
Publications
for LILRA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LILRA1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with LILRA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2, 3 Borges L....Cosman D. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1 Mosbruger T.L....Thio C.L. (2010)
- Alternative mRNA splicing creates transcripts encodin g soluble proteins from most LILR genes. (PubMed id 19658091)1 Jones D.C....Young N.T. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The LILR family: modulators of innate and adaptive immune pathways in health and disease. (PubMed id 15304001)1 Brown D....Allen R. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Killer cell Ig-like receptor and leukocyte Ig-like receptor transgenic mice exhibit tissue- and cell-specific transgene expression. (PubMed id 12960331)9 Belkin D....Trowsdale J. (2003)
- Crystal structure of myeloid cell activating receptor leukocyte Ig- like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. (PubMed id 19230061)9 Chen Y.... Gao G.F. (2009)
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External Searches for LILRA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing LILRA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LILRA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LILRA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LILRA1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for LILRA1 gene:
Search GeneIP for patents involving LILRA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LILRA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LILRA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LILRA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LILRA1 | | | OriGene Protein Over-expression Lysate for LILRA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LILRA1 | | OriGene 3'-UTR Clone for LILRA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LILRA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LILRA1 | | OriGene Custom Protein Services for LILRA1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LILRA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LILRA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LILRA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRA1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRA1 |
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