LIG3 Gene
protein-coding GIFtS: 67
GCID: GC17P033307
|
|
ligase III, DNA, ATP-dependent(Previous names: ligase II, DNA, ATP-dependent )
(Previous symbol: LIG2)
| |
Aliases
for LIG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ligase III, DNA, ATP-Dependent1 2 | | EC 6.5.1.13 8 | | LIG21 2 | | DNA Ligase 32 | | Ligase II, DNA, ATP-Dependent1 2 | | DNA Ligase III3 | | Polydeoxyribonucleotide Synthase [ATP] 32 3 | | |
Export aliases for LIG3 gene to outside databasesPrevious GC identifers: GC17P033077 GC17P035343 GC17P033453 GC17P030331 GC17P029493 |
Summaries
for LIG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LIG3:
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joiningof DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved inexcision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstreamstart codon allowing for transport to the mitochondria and translation initiation from a downstream start codonallowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding differentisoforms, have been characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916Function: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sisterchromatid exchange following treatment with ionizing radiation and alkylating agents
 summary
for LIG3: Ligases catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or
a similar triphosphate. They belong to the E.C. 6 class, which also includes synthases and carboxylases. DNA
ligases play an integral role in DNA repair and replication: they catalyze the formation of phosphodiester
bonds, using ATP as a co-factor. These enzymes are divided into three classes: DNA ligase I, III and IV. DNA
ligase I links Okazaki fragments to form a continuous strand of DNA. DNA ligase III is involved in base
excision repair. Finally, DNA ligase IV is involved in the repair of DNA double-strand breaks by
non-homologous end joining (NHEJ).
|
Genomic Views
for LIG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LIG3 gene promoter:
AML1a p53 FOXO3 FOXO3a Pax-2 Pax-2a LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LIG3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIG3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q12LIG3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P033307: view genomic region
(about GC identifiers)
Start:
|
33,307,513 bp from pter |
End:
|
33,332,088 bp from pter |
Size:
|
24,576 bases |
Orientation:
|
plus strand |
|
Proteins
for LIG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916 (See
protein sequence)Recommended Name: DNA ligase 3 Size: 1009 amino acids; 112907 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=AAA85022.1; Type=Erroneous initiation; Sequence=AAL91592.1; Type=Erroneous initiation;Sequence=CAA59230.1; Type=Erroneous initiation;
6/7 PDB 3D structures from  and Proteopedia  for LIG3 (see all 7):1IMO (3D)
1IN1 (3D)
1UW0 (3D)
3L2P (3D)
3PC7 (3D)
3PC8 (3D)
Secondary accessions: Q16714 Q6NVK3Alternative splicing: 2 isoforms: P49916-1 P49916-2 Explore the universe of human proteins at neXtProt for LIG3: NX_P49916
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49916
2 DME Specific Peptides for LIG3 (P49916)
LIG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_002302.2 NP_039269.2
ENSEMBL proteins: ENSP00000367787 ENSP00000468479 ENSP00000262327 ENSP00000467063 ENSP00000467757 ENSP00000466278 ENSP00000465288 Reactome Protein details: P49916
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
LIG3 for ontologies About GeneDecksing
LIG3 Antibody Products:
Assay Products for LIG3: |
Protein
Domains /
Families
for LIG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LIG3 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P49916ProtoNet protein and cluster: P49916 3 Blocks protein families: IPB001357 BRCT domain IPB001510 Zn-finger IPB012308 DNA ligase
UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916Similarity: Belongs to the ATP-dependent DNA ligase familySimilarity: Contains 1 BRCT domainSimilarity: Contains 1 PARP-type zinc finger |
Function
for LIG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916Function: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sisterchromatid exchange following treatment with ionizing radiation and alkylating agentsCatalytic activity: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate +(deoxyribonucleotide)(n+m) Genatlas biochemistry entry for LIG3:DNA ligase III,ATP-dependent,103kDa,complexing with LIG3,involved in DNA replication,recombination and DNArepair,highly expressed in testes
Enzyme Number (IUBMB): EC 6.5.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIG3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIG3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): LIG3 (NM_002311) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LIG3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIG3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIG3 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
LIG3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for LIG3:
Animal Models:
Mouse knock-out Lig3tm1Czhu for LIG3
10 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Lig3):
LIG3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for LIG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Resolution of Abasic Sites (AP sites) | | | 2 | Meiosis | | | 3 | Integrated Pancreatic Cancer Pathway | | | 4 | Base-Excision Repair, AP Site Formation | | | 5 | Global Genomic NER (GG-NER) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for LIG3
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LIG3
1  BioSystems Pathway for LIG3
4 
Reactome Pathways for LIG3
1 
Kegg Pathway (Kegg details for LIG3):
LIG3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LIG3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/31 Interacting proteins for LIG3 (P499162, 3 ENSP000003677874) via UniProtKB, MINT, STRING, and/or I2D (see all 31)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PIK3R1 | P279862, 3, ENSP000002743354 | MINT-8111871 I2D:
score=2 STRING: ENSP00000274335 | | PLCG1 | P191742, 3, ENSP000002440074 | MINT-8112471 I2D:
score=2 STRING: ENSP00000244007 | | XRCC1 | P188872, 3, ENSP000002628874 | MINT-4790124 I2D:
score=3 STRING: ENSP00000262887 | | PARP1 | P098742, 3, ENSP000003557594 | MINT-4790124 I2D:
score=1 STRING: ENSP00000355759 | | SRC | P129312, 3, ENSP000003509414 | MINT-8113023 I2D:
score=2 STRING: ENSP00000350941 |
About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
LIG3 for ontologies About GeneDecksing
|
Drugs & Compounds
for LIG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LIG3 for compounds About GeneDecksing
Compounds for LIG3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| L189 | DNA ligase I, III and IV inhibitor | [64232-83-3] |
4 HMDB Compounds for LIG3 About this table
1 DrugBank Compound for LIG3 About this table
7 Novoseek chemical compound relationships for LIG3 gene About this table
Search CenterWatch for drugs/clinical trials and news about LIG3 / DNLI3
|
Transcripts
for LIG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LIG3 gene (2 alternative transcripts): NM_002311.4 NM_013975.3 Unigene Cluster for LIG3: Ligase III, DNA, ATP-dependent Hs.100299 [show with all ESTs]Unigene Representative Sequence: NM_01397516 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378526(uc002hik.2) ENST00000585941 ENST00000262327(uc002hii.3 uc002hij.3 uc010cth.1)
ENST00000592690 ENST00000585740 ENST00000590181 ENST00000586407 ENST00000588109
ENST00000586435 ENST00000590630 ENST00000586058 ENST00000588713 ENST00000593099
ENST00000586119 ENST00000585370 ENST00000592244
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIG3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIG3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): LIG3 (NM_002311) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LIG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIG3 |
Additional cDNA sequence: AK127668.1 AK300363.1 AK308407.1 BC009026.1 BC068005.1 U40671.1 X84740.1 15 DOTS entries: DT.313674 DT.95088103 DT.100784860 DT.100784857 DT.120964172 DT.91749274 DT.95358707 DT.120964053 DT.100784856 DT.120964009 DT.120964125 DT.91704022 DT.91824684 DT.91837080 DT.100008759 24/150 AceView cDNA sequences (see all 150): CB127294 AA953450 CR616389 NM_013975 BM726768 BP873049 BQ024078 BC009026 BQ691150 AW236716 BX470676 BQ082820 AL528176 BE901311 AW950125 AI682152 BU171391 CA426477 U40671 BG230655 BF881950 BC068005 BG766643 BX280780
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LIG3 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LIG3
|
Expression
for LIG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LIG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAGAAAA
About this image
See LIG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LIG3
SOURCE GeneReport for Unigene cluster: Hs.100299
UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916Tissue specificity: Testis, thymus, prostate and heart
SABiosciences Expression via Pathway-Focused PCR Array including LIG3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LIG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LIG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIG3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIG3 |
Orthologs
for LIG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LIG3 gene from 4/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LIG31 |
ligase III, DNA, ATP-dependent |
73.86(n)
79.87(a) |
|
417530 NM_001006215.1 NP_001006215.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3982752 |
DNA ligase III isoform alpha |
76.11(n) |
|
AF393654.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
lig31 |
ligase III, DNA, ATP-dependent |
71.97(n)
77.28(a) |
|
563276 NM_001030174.1 NP_001025345.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG172273
lig31 |
DNA ligase (ATP)3
DNA ligase III1 |
45(a)3
52.8(n)1
47.4(a)1 |
|
87B93
415181 NM_141930.21 NP_650187.21 |
ENSEMBL Gene Tree for LIG3 (if available)
TreeFam Gene Tree for LIG3 (if available) |
Paralogs
for LIG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LIG3 gene
- LIG12
1 SIMAP similar gene for LIG3 using alignment to 8 protein entries: DNLI3_HUMAN (see all proteins):PARP1
LIG3 for paralogs About GeneDecksing
|
Genomic Variants
for LIG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LIG3 (33307513 - 33332088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LIG3: --
Human Gene Mutation Database (HGMD): LIG3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LIG3 |
|
Disorders
/ Diseases
for LIG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LIG3 for disorders About GeneDecksing
OMIM gene information: 600940
OMIM disorders: --
20/31  diseases for LIG3 (see all 31): About MalaCardsgraft versus host disease bloom syndrome axonal neuropathy esophageal squamous cell carcinoma
squamous cell carcinoma spinocerebellar ataxia chronic myeloid leukemia herpes simplex
epithelial ovarian cancer myeloid leukemia apraxia stomach cancer
multiple sclerosis ovarian cancer neuropathy lung cancer
vaccinia pulmonary disease ataxia esophagitis
2 Novoseek disease relationships for LIG3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bloom syndrome |
63.3 |
4 |
8532526 (1), 8265359 (1) |
| cancer |
0 |
1 |
15257099 (1) |
Genetic Association Database (GAD): LIG3
Human Genome Epidemiology (HuGE) Navigator: LIG3 (37 documents)
Export disorders for LIG3 gene to outside databases
|
Publications
for LIG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LIG3 gene, integrated from 9 sources (see all 148):
(articles sorted by number of sources associating them with LIG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. (PubMed id 7760816)1, 2, 3, 9 Wei Y.-F.... Lindahl T. (1995)
- Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. (PubMed id 7565692)1, 2, 9 Chen J.... Husain I. (1995)
- Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)1, 4 Zienolddiny S....Haugen A. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. (PubMed id 15205355)1, 4 Hao B....He F. (2004)
- Expression, purification, and biophysical characterization of the BRCT domain of human DNA ligase IIIalpha. (PubMed id 11281714)1, 2 Thornton K.H.... Cosman M. (2001)
- XRCC1 protein interacts with one of two distinct forms of DNA ligase III. (PubMed id 9136882)1, 9 Nash R.A....Lindahl T. (1997)
- An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. (PubMed id 8264637)1, 9 Caldecott K.W....Thompson L.H. (1994)
- A novel interaction between DNA ligase III and DNA polymerase gamma plays an essential role in mitochondrial DNA stability. (PubMed id 17054425)1, 9 De A. and Campbell C. (2007)
- Two DNA-binding and nick recognition modules in human DNA ligase III. (PubMed id 18238776)1, 9 Cotner-Gohara E....Ellenberger T. (2008)
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External Searches for LIG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing LIG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing LIG3 gene
(According to HUGE)
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Specialized Databases showing LIG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for LIG3 gene:
Search GeneIP for patents involving LIG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for LIG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for LIG3 | | OriGene shRNA RFP for LIG3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LIG3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LIG3 | | | OriGene Protein Over-expression Lysate for LIG3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LIG3 | | OriGene 3'-UTR Clone for LIG3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIG3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIG3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LIG3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LIG3 | | OriGene Custom Protein Services for LIG3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LIG3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LIG3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIG3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIG3 |
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| | | | Tocris compounds for LIG3 |
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 | | | LIG3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIG3 |
|  |  |  | | | | ThermoFisher Antibody for LIG3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIG3 |
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