V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

LIG3 Gene

protein-coding GIFtS: 68

GC17P030331

ligase III, DNA, ATP-dependent
(Previous names: ligase II, DNA, ATP-dependent )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LIG2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.5.1.1 ^³
LIG2 ^²

Descriptions
DNA ligase III ^³
Polydeoxyribonucleotide synthase [ATP] 3 ^³
ligase II, DNA, ATP-dependent ^¹, ²
ligase III, DNA, ATP-dependent ^²
polydeoxyribonucleotide synthase ^²

External Ids
HGNC: 6600¹
Entrez Gene: 3980²
UniProtKB: P49916³
Ensembl: ENSG00000005156⁷

Search outside databases for aliases for LIG3 gene

Previous GC identifers: GC17P033077 GC17P035343 GC17P033453

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LIG3:

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that

catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The

protein encoded by this gene is involved in excision repair and is located in both the

mitochondria and nucleus, with translation initiation from the upstream start codon allowing for

transport to the mitochondria and translation initiation from a downstream start codon allowing

for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding

different isoforms, have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916

Function: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair

and sister chromatid exchange following treatment with ionizing radiation and alkylating agents

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LIG3 gene

Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q12

LIG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P030331: (about GC identifiers)

Start:	30,331,651 bp from pter
End:	30,356,201 bp from pter
Size:	24,551 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010799.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916 (See protein sequence)

Recommended Name: DNA ligase 3

Size: 922 amino acids; 102691 Da

Cofactor: Magnesium (By similarity)

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1IMO (3D)

1IN1 (3D)

1UW0 (3D)

Secondary accessions: Q16714

Alternative splicing: 2 isoforms: P49916-1 P49916-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002302.2 NP_039269.2

ENSEMBL proteins:

ENSP00000367787 ENSP00000262327

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DNA Ligase III)
	Human Recombinant Proteins from Abnova (LIG3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	TAS	7565692
GO:0005654	nucleoplasm	EXP	8978692

About this table

Antibodies for LIG3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LIG3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DNA Ligase III), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LIG3)
	Novus Biologicals Antibodies for LIG3

Assays for LIG3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P49916

ProtoNet protein and cluster: P49916

3 Blocks protein families:

IPB001357 BRCT domain

IPB001510 Zn-finger

IPB012308 DNA ligase

UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916

Similarity: Belongs to the ATP-dependent DNA ligase family

Similarity: Contains 1 BRCT domain

Similarity: Contains 1 PARP-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LIG3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LIG3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002311

Applied Biosystems Silencer® siRNAs for LIG3

Sigma-Aldrich siRNA and siRNA Panels for LIG3

Sigma-Aldrich shRNA Panels and shRNA for LIG3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LIG3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002311
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002311
untagged cDNA clones in CMV expression vector (see all 3): NM_002311

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_013975

UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916

Function: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair

and sister chromatid exchange following treatment with ionizing radiation and alkylating agents

Catalytic activity: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate +

(deoxyribonucleotide)(n+m)

Enzyme Number (IUBMB): EC 6.5.1.1

Genatlas biochemistry entry for LIG3:

DNA ligase III,ATP-dependent,103kDa,complexing with LIG3,involved in DNA replication,recombination

and DNA repair,highly expressed in testes

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lig3):

cellular

embryogenesis

growth/size

lethality-prenatal/perinatal

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0003677	DNA binding	TAS	7565692
GO:0003910	DNA ligase (ATP) activity	IEA	--
GO:0005515	protein binding	IPI	17353931 17474147

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/37 Interacting proteins for LIG3 (P49916^{1, 2} ENSP00000367787³) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PNKP	Q96T60¹, ENSP00000323511³	EBI-1753381, EBI-1045072 STRING (score=.982)
PARP1	P09874², ENSP00000355759³	MINT-4790124 STRING (score=.792)
APLF	Q8IW19², ENSP00000307004³	MINT-4790124 STRING (score=.79)
RECQL	P46063², ENSP00000318727³	MINT-4790124 STRING (score=.705)
XRCC1	P18887¹^,², ENSP00000262887³	EBI-1753381, EBI-947466 MINT-4790124 EBI-1753381, EBI-947466 MINT-4790124 STRING (score=.999)

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	IEA	--
GO:0006281	DNA repair	TAS	7565692
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0007049	cell cycle	IEA	--
GO:0007131	reciprocal meiotic recombination	TAS	7565692

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LIG3
3 Novoseek chemical compound relationships for LIG3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
poly(ra).oligo(dt)	83.06	1	7510367 (1)
polynucleotide	63.76	2	11163244 (1), 15367657 (1)
zinc	28.38	12	10419478 (3), 12897160 (3), 9776738 (2), 17054425 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LIG3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LIG3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002311

Sigma-Aldrich siRNA and siRNA Panels for LIG3

Sigma-Aldrich shRNA Panels and shRNA for LIG3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002311 NM_013975

REFSEQ mRNAs for LIG3 gene (2 alternative transcripts):

NM_002311.3 NM_013975.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002311 NM_013975

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002311
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002311
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002311

Additional cDNA sequence:

AK127668.1 AK300363.1 AK308407.1 BC009026.1 BC068005.1 CR616389.1 U40671.1 X84740.1

15 DOTS entries:

DT.313674 DT.95088103 DT.100784860 DT.100784857 DT.120964172 DT.91749274 DT.95358707 DT.120964053

DT.91704022 DT.100784856 DT.120964009 DT.120964125 DT.91824684 DT.91837080 DT.100008759

24/150 AceView cDNA sequences (see all 150 ):

BX280780 BM927151 BF881950 BG766643 CB127294 AA953450 U40671 BQ691150

BX470676 AL528176 BQ082820 AW236716 BU171391 NM_013975 BM726768 CR616389

CA426477 AK125853 AW950125 BQ024078 AI682152 BG230655 BC009026 BP873049

highest scoring ESTs for LIG3:

X84740 AA029240 AA029241 AA149292 AA149406 AA531535 AA742510 AA872458 AA939162 AA953450

Unigene Cluster for LIG3:

Ligase III, DNA, ATP-dependent

Hs.100299 [show with all ESTs]

Unigene Representative Sequence: NM_013975

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LIG3 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^
SP1:													-						-						-																-				-
SP2:													-						-						-																-				-
SP3:									-		-		-						-						-
SP4:
SP5:

ExUns:	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:											-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LIG3

2 Ensembl transcripts including schematic representations:

ENST00000378526 ENST00000262327

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LIG3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LIG3

¹ / ² / ³

8 probe-sets matching LIG3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41099_at²^{, 3}	U95-A	1	1.00	1.00	0.87	1.15	X84740	1.00	1.00	1.00	1
1187_at²^{, 3}	U95-A	1	1.00	1.00	0.68	1.10	X84740	1.00	1.00	1.00	1
1188_g_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.77	X84740	1.00	1.00	1.00	1
204123_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_013975	0.60	1.00	0.82	1
207348_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002311	0.60	1.00	0.82	1
204123_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207348_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555169_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LIG3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGAAAGAAAA

SOURCE GeneReport for Unigene cluster: Hs.100299
Expression variation in blood from EXPOLDB for LIG3
UniProtKB/Swiss-Prot: DNLI3_HUMAN, P49916
Tissue specificity: Testis, thymus, prostate and heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LIG3 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LIG3¹	--	ligase III, DNA, ATP-dependent	89.84(n) 91.4(a)	491145 XM_548265.2 XP_548265.2
chimpanzee (Pan troglodytes)	LIG3¹	--	ligase III, DNA, ATP-dependent	99.78(n) 99.78(a)	454581 XM_511409.2 XP_511409.2
cow (Bos taurus)	LIG3¹	--	ligase III, DNA, ATP-dependent	89.18(n) 88.78(a)	514719 NM_001038107.1 NP_001033196.1
rat (Rattus norvegicus)	Lig3¹	--	ligase III, DNA, ATP-dependent	88.14(n) 90.21(a)	303369 NM_001012011.1 NP_001012011.1
mouse (Mus musculus)	Lig3^{1, 5}	11 (48.00 cM)⁵	ligase III, DNA, ATP-dependent^{1, 5}	87.64(n)¹ 88.4(a)¹	16882¹ NM_010716.2¹ NP_034846.2¹ AA409796⁵ AK010719⁵ (see all 24)

About this table Species with no ortholog for LIG3

ENSEMBL Gene Tree for LIG3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LIG3 gene

LIG4² LIG1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/154 NCBI SNPs in LIG3 are shown (see all 154 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 84)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1003918^1,2	A,C,F,H	30356290(+)	`AAAGGG/AGAGGT`	1	--	ng3¹		9		MN EU EA WA NA	966
	rs4796030^1,2	A,C,F,H	30354263(+)	`AAAAGC/ACCAGT`	2	--	int¹ ut3¹ ese³ trp³		7		EU EA WA NA	554
	rs1052536^1,2	A,C,F,H	30355688(+)	`TACTAC/TTGGAC`	1	--	ut3¹ ese³		23		EA MN CSAM NA EU WA	3300
	rs4986973^1,2	C,F,H	30355564(+)	`AGAACC/TCTGCG`	1	P/S	mis¹ ese³		13		MN CSAM EA EU WA NA	1098
	rs16970536^1,2	C,F,H	30356133(+)	`TTCAGC/GCTGAC`	1	--	ut3¹ ese³		11		NA EU EA WA	980
	rs3136025^1,2	C,F,H	30353162(+)	`GTCCCG/ACAAGG`	2	H/R	mis¹ ese³		25		NS MN CSAM EA NA EU WA	2472
	rs3744356^1,2	C,F,H	30337242(+)	`ATCCCC/TGGAAA`	2	R/W	mis¹ ese³		12		EA NA EU WA	2462
--	rs9898719^1,2	A,C	30354258(+)	`AAGGGA/GAAAGA`	2	--	ut3¹ int¹ trp³		0	--	--	--	--
--	rs3136031^1,2	C,F	30354738(+)	`CACCAT/CACCCG`	2	--	ng3¹ int¹		1		NS	170
--	rs12945428^1,2	F	30331699(+)	`CCCGCG/AGCCTG`	2	--	ut5¹ ese³		2		MN EA	1252

About this table

HapMap Linkage Disequilibrium images for LIG3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600940

2 Novoseek disease relationships for LIG3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bloom syndrome	64.89	4	8532526 (1), 8265359 (1)
cancer	0.00	1	15257099 (1)

About this table

Human Gene Mutation Database: LIG3
Genetic Association Database: LIG3
Human Genome Epidemiology Navigator: LIG3 (13 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/99 PubMed articles for LIG3 gene (see all 99 ):

Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. (PubMed id 7760816)^{1, 2, 3, 4} Wei Y.-F.... Lindahl T. (1995)
Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. (PubMed id 7565692)^{1, 3, 4} Chen J.... Husain I. (1995)
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)^{3, 6} Zienolddiny S....Haugen A. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. (PubMed id 15205355)^{3, 6} Hao B....He F. (2004)
Expression, purification, and biophysical characterization of the BRCT domain of human DNA ligase IIIalpha. (PubMed id 11281714)^{3, 4} Thornton K.H.... Cosman M. (2001)
XRCC1 protein interacts with one of two distinct forms of DNA ligase III. (PubMed id 9136882)^{1, 3} Nash R.A....Lindahl T. (1997)
An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. (PubMed id 8264637)^{1, 3} Caldecott K.W....Thompson L.H. (1994)
A novel interaction between DNA ligase III and DNA polymerase gamma plays an essential role in mitochondrial DNA stability. (PubMed id 17054425)^{1, 3} De A. and Campbell C. (2007)
Two DNA-binding and nick recognition modules in human DNA ligase III. (PubMed id 18238776)^{1, 3} Cotner-Gohara E....Ellenberger T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3980	HGNC: 6600	AceView: LIG3	Ensembl:ENSG00000005156	euGenes: HUgn3980
ECgene: LIG3	H-InvDB: LIG3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LIG3	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/DNA_ligase
NIEHS-SNPs	http://egp.gs.washington.edu/data/mpg/

Licensable Technologies for LIG3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LIG3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LIG3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LIG3		Antibodies for LIG3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LIG3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LIG3)
	Antibodies (LIG3)
	Chimera RNAi (LIG3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (DNA Ligase III)
	Antibodies (DNA Ligase III)

Search OriGene for LIG3

Search Tocris compounds for LIG3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LIG3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
LIG3 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

LIG3 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for LIG3

Summaries
for LIG3

Genomic Location
for LIG3

Proteins
for LIG3

Protein Domains/
Families
for LIG3

Gene Function
for LIG3

Pathways & Interactions
for LIG3

Drugs & Compounds
for LIG3

Transcripts
for LIG3

Expression
for LIG3

Orthologs
for LIG3

Paralogs
for LIG3

SNPs/Variants
for LIG3

Disorders & Mutations
for LIG3

Medical News
for LIG3

Publications
for LIG3

Search for LIG3

Genome Databases showing LIG3

Other Databases showing LIG3

Specialized Databases showing LIG3

Licensable Technologies
for LIG3

Services
for LIG3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LIG3 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor LIG3

Summariesfor LIG3

Genomic Locationfor LIG3

Proteinsfor LIG3

Protein Domains/Familiesfor LIG3

Gene Functionfor LIG3

Pathways & Interactionsfor LIG3

Drugs & Compoundsfor LIG3

Transcriptsfor LIG3

Expression for LIG3

Orthologsfor LIG3

Paralogsfor LIG3

SNPs/Variantsfor LIG3

Disorders & Mutationsfor LIG3

Medical Newsfor LIG3

Publicationsfor LIG3

Search for LIG3

Genome Databases showing LIG3

Other Databases showing LIG3

Specialized Databases showing LIG3

Licensable Technologiesfor LIG3

Servicesfor LIG3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LIG3

Summaries
for LIG3

Genomic Location
for LIG3

Proteins
for LIG3

Protein Domains/
Families
for LIG3

Gene Function
for LIG3

Pathways & Interactions
for LIG3

Drugs & Compounds
for LIG3

Transcripts
for LIG3

Expression
for LIG3

Orthologs
for LIG3

Paralogs
for LIG3

SNPs/Variants
for LIG3

Disorders & Mutations
for LIG3

Medical News
for LIG3

Publications
for LIG3

Licensable Technologies
for LIG3

Services
for LIG3