Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LIG3 Gene

Aliases for LIG3 Gene

  • Ligase III, DNA, ATP-Dependent 2 3
  • Polydeoxyribonucleotide Synthase [ATP] 3 3 4
  • Ligase II, DNA, ATP-Dependent 2 3
  • EC 6.5.1.1 4 64
  • DNA Ligase III 4
  • DNA Ligase 3 3
  • LIG2 3

External Ids for LIG3 Gene

Previous Symbols for LIG3 Gene

  • LIG2

Summaries for LIG3 Gene

Entrez Gene Summary for LIG3 Gene

  • This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIG3 Gene

LIG3 (Ligase III, DNA, ATP-Dependent) is a Protein Coding gene. Diseases associated with LIG3 include bloom syndrome. Among its related pathways are Chks in Checkpoint Regulation and DNA Repair. GO annotations related to this gene include DNA ligase activity and DNA ligase (ATP) activity. An important paralog of this gene is LIG4.

UniProtKB/Swiss-Prot for LIG3 Gene

  • Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).

Tocris Summary for LIG3 Gene

  • Ligases catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class, which also includes synthases and carboxylases. DNA ligases play an integral role in DNA repair and replication: they catalyze the formation of phosphodiester bonds, using ATP as a co-factor. These enzymes are divided into three classes: DNA ligase I, III and IV. DNA ligase I links Okazaki fragments to form a continuous strand of DNA. DNA ligase III is involved in base excision repair. Finally, DNA ligase IV is involved in the repair of DNA double-strand breaks by non-homologous end joining (NHEJ).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIG3 Gene

Genomics for LIG3 Gene

Genomic Location for LIG3 Gene

Start:
34,980,494 bp from pter
End:
35,009,743 bp from pter
Size:
29,250 bases
Orientation:
Plus strand

Genomic View for LIG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIG3 Gene

Regulatory Elements for LIG3 Gene

Proteins for LIG3 Gene

  • Protein details for LIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49916-DNLI3_HUMAN
    Recommended name:
    DNA ligase 3
    Protein Accession:
    P49916
    Secondary Accessions:
    • E5KLB5
    • E5KLB6
    • Q16714
    • Q6NVK3

    Protein attributes for LIG3 Gene

    Size:
    1009 amino acids
    Molecular mass:
    112907 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Isoform 3 interacts (via BRCT domain) with the nuclear DNA-repair protein XRCC1.

    Three dimensional structures from OCA and Proteopedia for LIG3 Gene

    Alternative splice isoforms for LIG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIG3 Gene

Proteomics data for LIG3 Gene at MOPED

Selected DME Specific Peptides for LIG3 Gene

Post-translational modifications for LIG3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys728 and Lys765

Other Protein References for LIG3 Gene

Domains for LIG3 Gene

UniProtKB/Swiss-Prot:

DNLI3_HUMAN
Domain:
  • The PARP-type zinc finger is required for DNA ligase activity.:
    • P49916
  • Contains 1 BRCT domain.:
    • P49916
Family:
  • Belongs to the ATP-dependent DNA ligase family.:
    • P49916
Similarity:
  • Contains 1 PARP-type zinc finger.:
    • P49916
genes like me logo Genes that share domains with LIG3: view

No data available for Gene Families for LIG3 Gene

Function for LIG3 Gene

Molecular function for LIG3 Gene

GENATLAS Biochemistry: DNA ligase III,ATP-dependent,103kDa,complexing with LIG3,involved in DNA replication,recombination and DNA repair,highly expressed in testes
UniProtKB/Swiss-Prot CatalyticActivity: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
UniProtKB/Swiss-Prot Function: Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).

Enzyme Numbers (IUBMB) for LIG3 Gene

Gene Ontology (GO) - Molecular Function for LIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003909 DNA ligase activity IDA 24674627
GO:0003910 DNA ligase (ATP) activity IMP 10207110
GO:0005515 protein binding IPI 15744309
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with LIG3: view
genes like me logo Genes that share phenotypes with LIG3: view

Animal Models for LIG3 Gene

MGI Knock Outs for LIG3:

miRNA for LIG3 Gene

miRTarBase miRNAs that target LIG3

No data available for Transcription Factor Targeting and HOMER Transcription for LIG3 Gene

Localization for LIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIG3 Gene

Isoform 1: Mitochondrion. Note=Contains an N-terminal mitochondrial transit peptide. {ECO:0000269 PubMed:10207110}.
Isoform 2: Mitochondrion. Note=Contains an N-terminal mitochondrial transit peptide. {ECO:0000305 PubMed:10207110}.
Isoform 3: Nucleus. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000269 PubMed:10207110}.
Isoform 4: Nucleus. Note=Lacks the N-terminal mitochondrial transit peptide. {ECO:0000305 PubMed:10207110}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIG3 Gene COMPARTMENTS Subcellular localization image for LIG3 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for LIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome --
GO:0000795 synaptonemal complex IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome --
genes like me logo Genes that share ontologies with LIG3: view

Pathways for LIG3 Gene

genes like me logo Genes that share pathways with LIG3: view

Gene Ontology (GO) - Biological Process for LIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006266 DNA ligation IDA 7565692
GO:0006273 NOT lagging strand elongation IBA --
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006288 base-excision repair, DNA ligation IMP 24674627
genes like me logo Genes that share ontologies with LIG3: view

Compounds for LIG3 Gene

(1) Tocris Compounds for LIG3 Gene

Compound Action Cas Number
L189 DNA ligase I, III and IV inhibitor [64232-83-3]

(4) HMDB Compounds for LIG3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for LIG3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Bleomycin
  • Bleocin
11056-06-7 target inhibitor

(7) Novoseek inferred chemical compound relationships for LIG3 Gene

Compound -log(P) Hits PubMed IDs
poly(ra).oligo(dt) 82.5 1
polynucleotide 76.2 3
adpribose 46.5 3
camptothecin 43 2
methylmethanesulfonate 42.5 1

(2) PharmGKB related drug/compound annotations for LIG3 Gene

Drug/compound Annotation
cisplatin CA
cyclophosphamide CA
genes like me logo Genes that share compounds with LIG3: view

Transcripts for LIG3 Gene

Unigene Clusters for LIG3 Gene

Ligase III, DNA, ATP-dependent:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIG3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5:
SP6: -
SP7: -
SP8:

ExUns: 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for LIG3 Gene

GeneLoc Exon Structure for
LIG3
ECgene alternative splicing isoforms for
LIG3

Expression for LIG3 Gene

mRNA expression in normal human tissues for LIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIG3 Gene

SOURCE GeneReport for Unigene cluster for LIG3 Gene Hs.100299

mRNA Expression by UniProt/SwissProt for LIG3 Gene

P49916-DNLI3_HUMAN
Tissue specificity: Testis, thymus, prostate and heart
genes like me logo Genes that share expressions with LIG3: view

Orthologs for LIG3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LIG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIG3 36
  • 99.7 (n)
  • 99.5 (a)
LIG3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LIG3 36
  • 89.18 (n)
  • 88.78 (a)
LIG3 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIG3 36
  • 88.49 (n)
  • 90.25 (a)
LIG3 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lig3 36
  • 87.64 (n)
  • 88.4 (a)
Lig3 16
Lig3 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LIG3 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIG3 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lig3 36
  • 88.14 (n)
  • 90.21 (a)
chicken
(Gallus gallus)
Aves LIG3 36
  • 74.1 (n)
  • 80.16 (a)
LIG3 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398275 36
tropical clawed frog
(Silurana tropicalis)
Amphibia lig3 36
  • 69.73 (n)
  • 77.02 (a)
zebrafish
(Danio rerio)
Actinopterygii lig3 36
  • 67.9 (n)
  • 70.96 (a)
lig3 37
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lig3 36
  • 54.2 (n)
  • 49.92 (a)
lig3 37
  • 39 (a)
OneToOne
CG17227 38
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea lig-4 37
  • 15 (a)
OneToOne
K07C5.3 38
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DNL4 37
  • 13 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12130 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToOne
Species with no ortholog for LIG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIG3 Gene

ENSEMBL:
Gene Tree for LIG3 (if available)
TreeFam:
Gene Tree for LIG3 (if available)

Paralogs for LIG3 Gene

Paralogs for LIG3 Gene

Selected SIMAP similar genes for LIG3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LIG3: view

Variants for LIG3 Gene

Sequence variations from dbSNP and Humsavar for LIG3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1003918 -- 35,005,158(+) AAAGG(A/G)GAGGT downstream-variant-500B
rs1052536 -- 35,004,556(+) TACTA(C/T)TGGAC utr-variant-3-prime, downstream-variant-500B
rs1076992 -- 34,983,093(-) ATCAC(A/G)CCAGT reference, missense
rs1802880 -- 34,998,650(+) GAAAG(A/T)CTATT reference, missense
rs2014060 -- 35,001,061(-) caggc(A/C)cggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIG3 Gene

Variant ID Type Subtype PubMed ID
nsv2035 CNV Loss 18451855

Relevant External Links for LIG3 Gene

HapMap Linkage Disequilibrium report
LIG3
Human Gene Mutation Database (HGMD)
LIG3

Disorders for LIG3 Gene

(1) MalaCards Diseases for LIG3 Gene

Search for LIG3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for LIG3 Gene

(2) Novoseek inferred disease relationships for LIG3 Gene

Disease -log(P) Hits PubMed IDs
bloom syndrome 63.3 2
cancer 0 1

Relevant External Links for LIG3

Genetic Association Database (GAD)
LIG3
Human Genome Epidemiology (HuGE) Navigator
LIG3
genes like me logo Genes that share disorders with LIG3: view

No data available for UniProtKB/Swiss-Prot for LIG3 Gene

Publications for LIG3 Gene

  1. Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. (PMID: 7760816) Wei Y.-F. … Lindahl T. (Mol. Cell. Biol. 1995) 2 3 4 23
  2. Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. (PMID: 7565692) Chen J. … Husain I. (Mol. Cell. Biol. 1995) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 49
  5. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PMID: 20496165) Monsees G.M. … Han J. (Breast Cancer Res. Treat. 2011) 3 49

Products for LIG3 Gene

Sources for LIG3 Gene

Back to Top

Content