Aliases for LIG1 Gene
External Ids for LIG1 Gene
Previous GeneCards Identifiers for LIG1 Gene
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for LIG1 Gene
LIG1 (Ligase I, DNA, ATP-Dependent) is a Protein Coding gene. Diseases associated with LIG1 include bloom syndrome. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include DNA ligase activity and DNA ligase (ATP) activity.
UniProtKB/Swiss-Prot for LIG1 Gene
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair
Ligases catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class, which also includes synthases and carboxylases. DNA ligases play an integral role in DNA repair and replication: they catalyze the formation of phosphodiester bonds, using ATP as a co-factor. These enzymes are divided into three classes: DNA ligase I, III and IV. DNA ligase I links Okazaki fragments to form a continuous strand of DNA. DNA ligase III is involved in base excision repair. Finally, DNA ligase IV is involved in the repair of DNA double-strand breaks by non-homologous end joining (NHEJ).