Aliases for LIG1 Gene
External Ids for LIG1 Gene
Previous GeneCards Identifiers for LIG1 Gene
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for LIG1 Gene
LIG1 (Ligase I, DNA, ATP-Dependent) is a Protein Coding gene. Diseases associated with LIG1 include bloom syndrome and uv-sensitive syndrome. Among its related pathways are Infectious disease and Cell Cycle, Mitotic. GO annotations related to this gene include DNA ligase activity and DNA ligase (ATP) activity.
UniProtKB/Swiss-Prot for LIG1 Gene
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair
Ligases are enzymes which catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class of enzymes, which also includes synthases and carboxylases.