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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LIF Gene

protein-coding   GIFtS: 65
GCID: GC22M030636

Leukemia Inhibitory Factor

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leukemia Inhibitory Factor1 2     Differentiation-Stimulating Factor2 3
HILDA2 3 5     Melanoma-Derived LPL Inhibitor2 3
Cholinergic Differentiation Factor1 2     MLPLI2 3
Differentiation Inhibitory Activity1 2     D Factor2 3
Differentiation-Inducing Factor1 2     CDF2
Hepatocyte-Stimulating Factor III1 2     DIA2
Human Interleukin In DA Cells1 2     Emfilermin3

External Ids:    HGNC: 65961   Entrez Gene: 39762   Ensembl: ENSG000001283427   OMIM: 1595405   UniProtKB: P150183   

Export aliases for LIF gene to outside databases

Previous GC identifers: GC22M027332 GC22M028960 GC22M013598


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIF Gene:
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved
in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal
cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also
have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for LIF Gene: 
LIF (leukemia inhibitory factor) is a protein-coding gene. Diseases associated with LIF include breast carcinoma in situ, and stachybotrys chartarum, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Rho Family GTPases. GO annotations related to this gene include cytokine activity and receptor binding.

UniProtKB/Swiss-Prot: LIF_HUMAN, P15018
Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the
induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell
differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes

Gene Wiki entry for LIF (Leukemia inhibitory factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LIF gene promoter:
         STAT1   ATF-2   STAT1beta   STAT5A   Max   STAT3   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIF promoter sequence
   Search SABiosciences Chromatin IP Primers for LIF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

LIF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIF gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M030636:  view genomic region     (about GC identifiers)

Start:
30,636,436 bp from pter      End:
30,642,840 bp from pter
Size:
6,405 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIF_HUMAN, P15018 (See protein sequence)
Recommended Name: Leukemia inhibitory factor precursor  
Size: 202 amino acids; 22008 Da
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for LIF:
1EMR (3D)        1PVH (3D)        2Q7N (3D)    
Secondary accessions: B2RCW7 B5MC23 Q52LZ2
Alternative splicing: 2 isoforms:  P15018-1   P15018-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LIF: NX_P15018

Explore proteomics data for LIF at MOPED 

LIF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

LIF Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001244064.1  NP_002300.1  

ENSEMBL proteins: 
 ENSP00000249075   ENSP00000384450  

Human Recombinant Protein Products for LIF: 
EMD Millipore Purified and/or Recombinant LIF Protein
R&D Systems Recombinant & Natural Proteins for LIF
Enzo Life Sciences proteins for LIF
OriGene Purified Proteins for LIF
OriGene Protein Over-expression Lysate for LIF
OriGene MassSpec for LIF 
OriGene Custom Protein Services for LIF
GenScript Purified and Recombinant Proteins for LIF
Novus Biologicals LIF Proteins
Novus Biologicals LIF Lysates
Sino Biological Recombinant Protein for LIF
Sino Biological Cell Lysate for LIF 
ProSpec Recombinant Protein for LIF
Cloud-Clone Corp. Proteins for LIF 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IC12643274
GO:0005737cytoplasm IDA--

LIF for ontologies           About GeneDecksing



LIF Antibody Products: 
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Abcam antibodies for LIF
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ThermoFisher Antibodies for LIF
LSBio Antibodies in human, mouse, rat for LIF 

Assay Products for LIF: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for LIF
R&D Systems ELISAs for LIF         (see all)
GenScript Custom Assay Services for LIF
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for LIF 
Cloud-Clone Corp. CLIAs for LIF


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5 InterPro protein domains:
 IPR009079 4_helix_cytokine-like_core
 IPR003624 Leukemia_IF
 IPR012351 4_helix_cytokine_core
 IPR019827 Leukemia_IF/oncostatin_CS
 IPR001581 Leukemia_IF/oncostatin

Graphical View of Domain Structure for InterPro Entry P15018

ProtoNet protein and cluster: P15018

1 Blocks protein domain: IPB003624 Leukemia inhibitory factor

UniProtKB/Swiss-Prot: LIF_HUMAN, P15018
Similarity: Belongs to the LIF/OSM family


LIF for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: LIF_HUMAN, P15018
Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the
induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell
differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes

     Genatlas biochemistry entry for LIF:
leukemia inhibitory factor (differentiation-stimulating factor),interleukin-6 cytokine family member stimulating
hematopoiesis,platelet production,localized distally to the breakpoint in t(11;22)(q24;q12)

     Summary:
During embryonic development, LIF as signaling molecule
affects the following cells: Late Retinal Progenitor Cells in Retinal Neuroblastic Layer

LIF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Secondary spheres from , Dopaminergic neurons from Brain (see all).

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001135RNA polymerase II transcription factor recruiting transcription factor activity IDA--
GO:0005102receptor binding IPI8999038
GO:0005125cytokine activity IDA7957045
GO:0005146leukemia inhibitory factor receptor binding IPI8999038
GO:0008083growth factor activity IDA12643274
     
LIF for ontologies           About GeneDecksing


Phenotypes:
     5 GenomeRNAi human phenotypes for LIF:
 Decreased G3BP1 protein expres  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
 Increased HDAC inhibitor resis 

     15/20 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lif) (see all 20):
 adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
 embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
 immune system  integument  liver/biliary system  mortality/aging  muscle 

LIF for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for LIF: Liftm1Cgre Liftm1Stw

   inGenious Targeting Laboratory - Custom generated mouse model solutions for LIF 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LIF

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIF 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIF 

miRNA
Products:
    
miRTarBase miRNAs that target LIF:
hsa-mir-125a-5p (MIRT004326), hsa-mir-26a (MIRT001039), hsa-mir-125b (MIRT001037), hsa-mir-346 (MIRT001040), hsa-mir-199a-5p (MIRT004325)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIF
8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate LIF (see all 91):
hsa-miR-520e hsa-miR-520f hsa-miR-3194-5p hsa-miR-106a hsa-miR-1224-3p hsa-miR-3921 hsa-miR-3916 hsa-miR-3150b-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for LIF
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIF

Gene Editing
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DNA2.0 Custom Protein Engineering Service for LIF
Sirion Biotech Customized adenovirus for overexpression of LIF

Clone
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OriGene clones in human, mouse for LIF (see all 7)
OriGene ORF clones in mouse, rat for LIF
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LIF (NM_002309)
Sino Biological Human cDNA Clone for LIF
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIF
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIF
Sirion Biotech Customized lentivirus for stable overexpression of LIF 
                     Customized lentivirus expression plasmids for stable overexpression of LIF 

Cell Line
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GenScript Custom overexpressing Cell Line Services for LIF
Search LifeMap BioReagents cell lines for LIF
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIF


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for LIF About   (see all 15)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
IL-6 Pathway0.61
MIF Regulation of Innate Immune Cells0.94
STAT3 Pathway0.47
PEDF Induced Signaling0.73
Endothelin-1 Signaling Pathway0.46
all-trans-Retinoic Acid Signaling in Brain0.71
Cytokine-cytokine receptor interaction0.43
2Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
3Akt Signaling
Akt Signaling0.60
p38 Signaling0.60
4PAK Pathway
PAK Pathway0.56
Antioxidant Action of Vitamin-C0.56
5NFAT and Cardiac Hypertrophy
NFAT and Cardiac Hypertrophy0.42
Signaling Involved in Cardiac Hypertrophy0.42

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for LIF
    Selected targets of CREB1
Selected targets of p53

5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LIF (see all 18)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
ERK5 Signaling
Signaling Involved in Cardiac Hypertrophy

5 BioSystems Pathways for LIF
    MicroRNAs in cardiomyocyte hypertrophy
TGF Beta Signaling Pathway
Adipogenesis
Direct p53 effectors
Validated transcriptional targets of AP1 family members Fra1 and Fra2



3         Kegg Pathways  (Kegg details for LIF):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
TNF signaling pathway


LIF for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LIF

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/11 Interacting proteins for LIF (P150182, 3 ENSP000002490754) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
LIFRP427022, 3, ENSP000002634094MINT-62477 MINT-62475 I2D: score=4 STRING: ENSP00000263409
IL6STP401892, 3, ENSP000003387994MINT-62483 I2D: score=5 STRING: ENSP00000338799
CNTFRP269923I2D: score=1 
JUNENSP000003602664STRING: ENSP00000360266
TP53ENSP000002693054STRING: ENSP00000269305
About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001974blood vessel remodeling IEA--
GO:0006955immune response IEA--
GO:0007275multicellular organismal development TAS3143918
GO:0007566embryo implantation IEA--
GO:0008284positive regulation of cell proliferation IDA7957045

LIF for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LIF for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LIF

UniProtKB/Swiss-Prot: LIF_HUMAN, P15018
Pharmaceutical: In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in
women who have failed to become pregnant despite assisted reproductive technologies (ART)

10/107 Novoseek inferred chemical compound relationships for LIF gene (see all 107)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130 95.4 406 12799551 (5), 9568895 (5), 9712900 (5), 12574225 (4) (see all 99)
toxohormone-l 65.8 2 7622421 (1), 8765417 (1)
il 11 61.8 5 19647472 (2), 8605875 (1)
tyrosine 53 49 8900046 (3), 18174171 (2), 8174677 (2), 7688764 (2) (see all 34)
progesterone 47 77 9835355 (5), 16055453 (4), 18675966 (3), 11574494 (3) (see all 37)
tgf beta1 44.5 13 9714521 (2), 14968036 (2), 17034864 (1), 14627547 (1) (see all 9)
pd 98,059 40.4 7 10217263 (1), 12145097 (1), 19340839 (1), 18252965 (1) (see all 6)
rantes 37.6 15 12620497 (2), 8626989 (2), 15708128 (1), 9764576 (1) (see all 10)
gm-csf 37.1 2 8769977 (1), 7683736 (1)
onapristone 34.7 3 11420216 (2)

Search CenterWatch for drugs/clinical trials and news about LIF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LIF gene (2 alternative transcripts): 
NM_001257135.1  NM_002309.4  

Unigene Cluster for LIF:

Leukemia inhibitory factor
Hs.2250  [show with all ESTs]
Unigene Representative Sequence: NM_002309
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000249075(uc003agz.2 uc011aks.1) ENST00000403987

miRNA
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8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate LIF (see all 91):
hsa-miR-520e hsa-miR-520f hsa-miR-3194-5p hsa-miR-106a hsa-miR-1224-3p hsa-miR-3921 hsa-miR-3916 hsa-miR-3150b-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: LIF (NM_002309)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIF
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIF
Sirion Biotech Customized lentivirus for stable overexpression of LIF 
                     Customized lentivirus expression plasmids for stable overexpression of LIF 
Primer
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OriGene qPCR primer pairs and template standards for LIF
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LIF
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIF
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIF

Additional mRNA sequence: 

AK315310.1 BC069540.1 BC093733.1 BC093735.1 BC143305.1 X13967.1 

3 DOTS entries:

DT.210986  DT.100744740  DT.91970156 

24/47 AceView cDNA sequences (see all 47):

H55709 R50018 AL711919 BU175373 BM129796 CK819709 BC069540 CA430261 
AI889752 NM_002309 X13967 BX099968 BM561741 BE349408 BQ691666 CB217076 
BP366214 BU197122 CD614554 AI570795 BF125116 AW571472 CD614555 W46451 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LIF expression in normal human tissues (normalized intensities)      LIF embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCTTGGGTG
LIF Expression
About this image


LIF expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/8 selected tissues (see all 8) fully expand
 
 Zygote (Early Embryonic Tissues)    fully expand to see all 3 entries
         Zygote Zygote
 
 Inner Cell Mass (Early Embryo)    fully expand to see all 3 entries
         Zygote Zygote
 
 Trophoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
         Zygote Zygote
 
 Epidermis (Integumentary System)
         MSC-containing human skin substitute (Grafix)
 
 Adipose (Muscoskeletal System)
         Visceral White Preadipocytes Visceral White Adipose

See LIF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LIF

SOURCE GeneReport for Unigene cluster: Hs.2250
    SABiosciences Expression via Pathway-Focused PCR Arrays including LIF (see all 10): 
          Neurogenesis in human mouse rat
          Growth Factors in human mouse rat
          Stem Cell Transcription Factors in human mouse rat
          Interferons & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIF
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIF
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIF

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LIF gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lif1 , 5 leukemia inhibitory factor1, 5 81.19(n)1
80.2(a)1
  11 (2.94 cM)5
168781  NM_008501.21  NP_032527.11 
 42575575 
chicken
(Gallus gallus)
Aves LIF1 leukemia inhibitory factor (cholinergic differentiation more 59.62(n)
43.3(a)
  427718  XM_425293.3  XP_425293.3 


ENSEMBL Gene Tree for LIF (if available)
TreeFam Gene Tree for LIF (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/192 SNPs in LIF are shown (see all 192)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs57639081,2
C,F--14558289(+) acctcC/Ttggga 2 -- ds50011Minor allele frequency- T:0.07EA 120
rs1914823011,2
--14558322(+) CACCCC/TGAGTA 2 -- ds50010--------
rs601013771,2
C,F--14558472(+) ACAGGA/TGTGAC 2 -- ds50012Minor allele frequency- T:0.04WA 120
rs15578331,2
C,F,A,H--14558618(+) CCCTCA/CCCCAC 2 -- ds500112Minor allele frequency- C:0.45EA NS NA WA CSA 1963
rs1823884961,2
--14558639(+) CCTTCA/GCTGAG 2 -- ds50010--------
rs778807771,2
--14558739(+) GTAGAA/TTCTTT 2 -- ut310--------
rs1880500601,2
--14558821(+) CATTGA/TATAAA 2 -- ut310--------
rs1501681841,2
C--14558968(+) AGCACA/GTGGGC 2 -- ut310--------
rs96067061,2
C,F--14558993(+) GATGCC/G/TGGGAT 4 -- ut31 ese34NA CSA EA 243
rs1386741221,2
--14559404(+) CTGTGC/TAGGGT 2 -- ut310--------

HapMap Linkage Disequilibrium report for LIF (30636436 - 30642840 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for LIF:    About this table     
Variant IDTypeSubtypePubMed ID
dgv4954n71CNV Loss21882294
nsv829171CNV Loss20364138
dgv4955n71CNV Loss21882294
nsv914970CNV Loss21882294
nsv834173CNV Loss17160897
esv995861CNV Gain20482838
nsv834174CNV Gain+Loss17160897


Human Gene Mutation Database (HGMD): LIF
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing LIF
DNA2.0 Custom Variant and Variant Library Synthesis for LIF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 159540    OMIM disorders: --

20/111 diseases for LIF (see all 111):    About MalaCards
breast carcinoma in situ    stachybotrys chartarum    langerhans-cell histiocytosis    complement deficiency
acth-secreting pituitary adenoma    skeletal muscle regeneration    neuroepithelioma    histiocytosis
diabetic polyneuropathy    meningococcemia    thrombocytosis    plasmacytoma
ectopic pregnancy    pituitary adenoma    myeloid leukemia    refractory anemia
adenomyosis    myelofibrosis    subacute sclerosing panencephalitis    allergic contact dermatitis


LIF for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/91 Novoseek inferred disease relationships for LIF gene (see all 91)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia 94.9 2672 10212267 (7), 9822513 (7), 8987949 (7), 18240017 (6) (see all 99)
necrosis 54.1 147 8313662 (2), 8137298 (2), 7760346 (2), 16477612 (2) (see all 99)
myeloid leukemia 52.3 20 1908551 (2), 8564713 (1), 8462021 (1), 8632998 (1) (see all 13)
miscarriage recurrent 52.1 18 16126674 (3), 9734394 (3), 17034864 (1), 17156190 (1) (see all 8)
abortion inevitable 51.5 20 16640878 (4), 11930689 (3)
response acute phase 51 11 1714773 (2), 1281789 (1), 12773095 (1), 1718962 (1) (see all 9)
neuroepithelioma 46.4 5 7622421 (1), 8765417 (1), 14647442 (1)
complement deficiency 44.8 1 7660072 (1)
infertility 43.2 57 9506211 (4), 14687743 (4), 19545488 (4), 11783352 (3) (see all 26)
choriocarcinoma 42.7 6 16125646 (1), 8833034 (1), 12606473 (1), 15837065 (1) (see all 5)

Genetic Association Database (GAD): LIF
Human Genome Epidemiology (HuGE) Navigator: LIF (25 documents)
Tumor Gene Database (TGDB): LIF

Export disorders for LIF gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for LIF gene, integrated from 9 sources (see all 1211):
(articles sorted by number of sources associating them with LIF)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Leukaemia inhibitory factor (LIF) gene mutations in w omen diagnosed with unexplained infertility and endometriosis have a negative i mpact on the IVF outcome. A pilot study. (PubMed id 19545488)1, 4, 9 NovotnA1 Z....KrA!lA-ckovA! M. (2009)
  2. [The leukemia inhibitory factor gene mutations in the population of infertile women: the heterozygote transition G to A on the position 3400 does not affect the outcome of the infertility treatment] (PubMed id 17966612)1, 4, 9 Kralickova M....Hes O. (2007)
  3. An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. (PubMed id 17652170)1, 2, 9 Huyton T....Garrett T.P. (2007)
  4. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (PubMed id 14527405)1, 2, 9 Boulanger M.J.... Garcia K.C. (2003)
  5. Neuropoietic cytokines in the hematopoietic fold. (PubMed id 1714745)1, 3, 9 Bazan J.F. (1991)
  6. Single-nucleotide polymorphisms in the p53 pathway re gulate fertility in humans. (PubMed id 19470478)1, 4, 9 Kang H.J....Hu W. (2009)
  7. Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population. (PubMed id 19251277)1, 4, 9 Mackenzie J....Griffiths L.R. (2009)
  8. Association of the leukemia inhibitory factor gene mutation and the antiphospholipid antibodies in the peripheral blood of infertile women. (PubMed id 18298054)1, 4, 9 Kralickova M....Vetvicka V. (2007)
  9. No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis. (PubMed id 16263181)1, 4, 9 Vanderlocht J....Hellings N. (2006)
  10. Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene. (PubMed id 11587067)1, 4, 9 Ishida R....Emi M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3976 HGNC: 6596 AceView: LIF Ensembl:ENSG00000128342 euGenes: HUgn3976
ECgene: LIF Kegg: 3976 H-InvDB: LIF

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for LIF Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LIF Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Leukemia_inhibitory_factor

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for LIF gene:
Search GeneIP for patents involving LIF

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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