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LIF Gene

protein-coding GIFtS: 68

GC22M028960

leukemia inhibitory factor (cholinergic differentiation factor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CDF ^¹, ²
DIA ^²
Emfilermin ^³
HILDA ^², ³, ⁵
MLPLI ^³

Descriptions
D factor ^², ³
Differentiation-stimulating factor ^³
Melanoma-derived LPL inhibitor ^³
cholinergic differentiation factor ^²
differentiation inhibitory activity ^²
differentiation stimulating factor ^²
leukemia inhibitory factor (cholinergic differentiation factor) ^²

External Ids
HGNC: 6596¹
Entrez Gene: 3976²
UniProtKB: P15018³
Ensembl: ENSG00000128342⁷

Search outside databases for aliases for LIF gene

Previous GC identifer: GC22M027332

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LIF:

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems.

It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia

cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial

conversion during kidney development, and may also have a role in immune tolerance at the

maternal-fetal interface. [provided by RefSeq]

UniProtKB/Swiss-Prot: LIF_HUMAN, P15018

Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities

include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the

induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis

in hepatocytes

Gene Wiki entry for LIF (Leukemia_inhibitory_factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LIF gene

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

LIF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M028960: (about GC identifiers)

Start:	28,966,441 bp from pter
End:	28,972,748 bp from pter
Size:	6,308 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LIF_HUMAN, P15018 (See protein sequence)

Recommended Name: Leukemia inhibitory factor precursor

Size: 202 amino acids; 22008 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1A7M (3D)

1EMR (3D)

1PVH (3D)

2Q7N (3D)

Secondary accessions: Q52LZ2

REFSEQ proteins: NP_002300.1

ENSEMBL proteins:

ENSP00000249075 ENSP00000384450

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant LIF Protein
	Sigma-Aldrich Proteins for LIF
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LIF)
	Human Recombinant Proteins from Abnova (LIF)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for LIF:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of LIF
	Sigma-Aldrich Antibodies for LIF
	R&D Systems Antibodies for LIF
	Antibodies from Abcam (LIF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LIF)
	Novus Biologicals Antibody for LIF

Assays for LIF:

	Invitrogen Assays for LIF
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for LIF (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P15018

ProtoNet protein and cluster: P15018

1 Blocks protein family: IPB003624 Leukemia inhibitory factor

UniProtKB/Swiss-Prot: LIF_HUMAN, P15018

Similarity: Belongs to the LIF/OSM family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LIF)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002309

Applied Biosystems Silencer® siRNAs for LIF

Sigma-Aldrich siRNA and siRNA Panels for LIF

Sigma-Aldrich shRNA Panels and shRNA for LIF

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LIF
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002309
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002309
untagged cDNA clone in CMV expression vector: NM_002309

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002309

UniProtKB/Swiss-Prot: LIF_HUMAN, P15018

Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities

include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the

induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis

in hepatocytes

Genatlas biochemistry entry for LIF:

leukemia inhibitory factor (differentiation-stimulating factor),interleukin-6 cytokine family

member stimulating hematopoiesis,platelet production,localized distally to the breakpoint in

t(11;22)(q24;q12)

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Lif):

embryogenesis	growth/size	hematopoietic system	immune system	no phenotypic analysis
reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IDA	7957045
GO:0005146	leukemia inhibitory factor receptor binding	IDA	7957045
GO:0008083	growth factor activity	IDA	7957045

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for LIF (Your Favorite Gene powered by Ingenuity)

Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency

GeneDecks LIF for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for LIF

5/77 Interacting proteins for LIF (ENSP00000249075³ P15018²) via UniProtKB, MINT, and/or STRING (see all 77 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LIFR	P42702²	STRING (score=.999) MINT-62477 MINT-62475
IL6ST	P40189²	STRING (score=.999) MINT-62483
OSM	ENSP00000215781³	STRING (score=.998)
IL6	ENSP00000258743³	STRING (score=.99)
IL11	ENSP00000264563³	STRING (score=.988)

About this table

5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0007275	multicellular organismal development	TAS	3143918
GO:0008284	positive regulation of cell proliferation	IDA	7957045
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	7508917
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	IDA	12643274

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LIF
UniProtKB/Swiss-Prot: LIF_HUMAN, P15018

Pharmaceutical: In phase II clinical trial. The drug is being developed by Amrad to assist embryo

implantation in women who have failed to become pregnant despite assisted reproductive

technologies (ART)

10/57 Novoseek chemical compound relationships for LIF gene (see all 57 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130	95.56	399	12799551 (5), 9568895 (5), 9712900 (5), 12574225 (4) (see all 99)
toxohormone-l	66.26	2	7622421 (1), 8765417 (1)
tyrosine	54.39	49	8900046 (3), 18174171 (2), 8174677 (2), 7688764 (2) (see all 34)
tgf beta1	46.24	13	9714521 (2), 14968036 (2), 17034864 (1), 14627547 (1) (see all 9)
progesterone	45.11	68	9835355 (5), 16055453 (4), 11574494 (3), 11062850 (3) (see all 33)
pd 98,059	40.49	6	10217263 (1), 12145097 (1), 18252965 (1), 17392578 (1) (see all 5)
rantes	39.08	15	12620497 (2), 8626989 (2), 15708128 (1), 9764576 (1) (see all 10)
acth	35.09	72	7883977 (5), 8923879 (5), 18638665 (4), 8770940 (4) (see all 19)
ribonucleic acid	29.39	7	11314490 (1), 10833369 (1), 10842275 (1), 12605541 (1) (see all 5)
chymotrypsinogen	24.79	3	10022823 (1), 7592653 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LIF)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002309

Sigma-Aldrich siRNA and siRNA Panels for LIF

Sigma-Aldrich shRNA Panels and shRNA for LIF

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002309

REFSEQ mRNAs for LIF gene:

NM_002309.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002309

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002309
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002309
                                 untagged cDNA clone in CMV expression vector: NM_002309

Additional cDNA sequence:

AK315310.1 BC069540.1 BC093733.1 BC093735.1 BC143305.1 X13967.1

2 DOTS entries:

DT.210986 DT.100744740

24/47 AceView cDNA sequences (see all 47 ):

R50018 BC069540 BM129796 H55709 BU175373 CK819709 AL711919 BE349408

CA430261 AI889752 BU197122 BP366214 CB217076 BX099968 BM561741 BQ691666

X13967 CD614554 NM_002309 CO249535 AW571472 AI570795 AI983629 CB216985

highest scoring ESTs for LIF:

X13967 BC069540 H55709 AI147138 AI287298 AI796373 AI889752 AI922369 AI983629 AL711919

Unigene Cluster for LIF:

Leukemia inhibitory factor (cholinergic differentiation factor)

Hs.2250 [show with all ESTs]

Unigene Representative Sequence: NM_002309

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000249075 ENST00000403987

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LIF expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LIF

¹ / ² / ³

3 probe-sets matching LIF gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
441_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X13967	1.00	1.00	1.00	1
205266_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002309	0.60	1.00	0.82	1
205266_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCTTGGGTG

SOURCE GeneReport for Unigene cluster: Hs.2250
Expression variation in blood from EXPOLDB for LIF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LIF gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LIF¹	--	leukemia inhibitory factor (cholinergic differentiation more	91.91(n) 92.08(a)	403449 XM_534732.2 XP_534732.2
chimpanzee (Pan troglodytes)	LIF¹	--	leukemia inhibitory factor (cholinergic differentiation more	99.79(n) 100(a)	736309 XM_001140005.1 XP_001140005.1
cow (Bos taurus)	LIF¹	--	leukemia inhibitory factor (cholinergic differentiation more	88.61(n) 89.11(a)	280840 NM_173931.1 NP_776356.1
rat (Rattus norvegicus)	Lif¹	--	leukemia inhibitory factor (cholinergic differentiation more	82.51(n) 82.67(a)	60584 NM_022196.1 NP_071532.1
mouse (Mus musculus)	Lif^{1, 5}	11 (0.25 cM)⁵	leukemia inhibitory factor^{1, 5}	81.19(n)¹ 80.2(a)¹	16878¹ NM_008501.2¹ NP_032527.1¹ A01670⁵ AF065917⁵ (see all 21)

About this table Species with no ortholog for LIF

ENSEMBL Gene Tree for LIF

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/48 NCBI SNPs in LIF are shown (see all 48 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 34)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs929272^1,2	A,C,F,H,O	28968292(+)	`GACACC/GCTAAA`	1	--	ut3¹		10	MN EU EA NA WA	1980
	rs2267153^1,2	A,C,F,H	28973609(+)	`TCCTCC/GGGGTG`	1	--	ng3¹ trp³		4	EU EA WA	418
	rs737812^1,2	A,C,F,H	28969110(+)	`GACAGC/ACTTCC`	1	--	ut3¹		12	MN EA NA WA	1060
	rs929271^1,2	A,C,F,H	28968226(+)	`TGGAAT/GCAAGA`	1	--	ut3¹ ese³		5	MN EU EA WA	602
	rs1557833^1,2	A,C,F,H	28966331(+)	`CCCTCA/CCCCAC`	1	--	ng5¹		4	EA WA	1596
	rs3753082^1,2	A,C,F	28968721(-)	`GGAGGC/TCTTGT`	1	--	ut3¹ ese³		5	EA NA	1604
	rs2412983^1,2	H	28969905(+)	`CCAGGG/AAGGTG`	1	F/S	mis¹ ese³		4	EU EA WA	382
	rs2412982^1,2	H	28969850(+)	`CTGTGG/AAGGCT`	1	L/L	syn¹ ese³		4	EU EA WA	416
	rs929273^1,2	A,C,F,H	28970595(+)	`GTGGCG/AGGAGT`	1	--	int¹		8	EA NA EU WA	572
	rs737921^1,2	A,C,F,H	28970214(+)	`TAATTG/ATAATG`	1	--	int¹		17	NA EA NS EU WA	1923

About this table

HapMap Linkage Disequilibrium images for LIF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 159540

10/92 Novoseek disease relationships for LIF gene (see all 92 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	94.90	2538	10212267 (7), 9822513 (7), 8987949 (7), 18240017 (6) (see all 99)
necrosis	55.09	144	8313662 (2), 8137298 (2), 7760346 (2), 16477612 (2) (see all 97)
myeloid leukemia	53.47	20	1908551 (2), 8564713 (1), 8462021 (1), 8632998 (1) (see all 13)
abortion inevitable	52.57	20	16640878 (4), 11930689 (3)
response acute phase	52.04	11	1714773 (2), 1281789 (1), 12773095 (1), 1718962 (1) (see all 9)
miscarriage recurrent	50.09	18	16126674 (3), 9734394 (3), 17034864 (1), 17156190 (1) (see all 8)
neuroepithelioma	47.24	5	7622421 (1), 8765417 (1), 14647442 (1)
complement deficiency	46.54	1	7660072 (1)
carcinoma embryonal	43.11	8	1322335 (2), 15641927 (2), 10366419 (1), 10202003 (1) (see all 5)
choriocarcinoma	42.14	6	16125646 (1), 8833034 (1), 12606473 (1), 15837065 (1) (see all 5)

About this table

Human Gene Mutation Database: LIF
Genetic Association Database: LIF
Human Genome Epidemiology Navigator: LIF (10 documents)
Tumor Gene Database: LIF

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1060 PubMed articles for LIF gene (see all 1060 ):

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. (PubMed id 17652170)^{1, 3, 4} Huyton T....Garrett T.P. (2007)
Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (PubMed id 14527405)^{1, 3, 4} Boulanger M.J.... Garcia K.C. (2003)
Neuropoietic cytokines in the hematopoietic fold. (PubMed id 1714745)^{1, 2, 3} Bazan J.F. (1991)
No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis. (PubMed id 16263181)^{1, 3, 6} Vanderlocht J....Hellings N. (2006)
Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene. (PubMed id 11587067)^{1, 3, 6} Ishida R....Emi M. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{3, 4} Dunham I....O'Brien K.P. (1999)
Solution structure of leukemia inhibitory factor. (PubMed id 9593715)^{3, 4} Hinds M.G.... Norton R.S. (1998)
Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology. (PubMed id 8058719)^{2, 3} Patterson P.H. (1994)
Glycosylation pattern and disulfide assignments of recombinant human differentiation-stimulating factor. (PubMed id 8489250)^{3, 4} Schmelzer C.H....Burton L.E. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3976	HGNC: 6596	AceView: LIF	Ensembl:ENSG00000128342	euGenes: HUgn3976
ECgene: LIF	H-InvDB: LIF

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LIF	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Leukemia_inhibitory_factor

Licensable Technologies for LIF
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LIF:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LIF-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LIF		Antibodies for LIF
	Explore super-pooled esiRNAs		Proteins for LIF
	Lentivirus-delivered shRNAs for LIF		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LIF)
	Antibodies (LIF)
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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for LIF

Search Tocris compounds for LIF

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LIF

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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LIF Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for LIF

Summaries
for LIF

Genomic Location
for LIF

Proteins
for LIF

Protein Domains/
Families
for LIF

Gene Function
for LIF

Pathways & Interactions
for LIF

Drugs & Compounds
for LIF

Transcripts
for LIF

Expression
for LIF

Orthologs
for LIF

Paralogs
for LIF

SNPs/Variants
for LIF

Disorders & Mutations
for LIF

Medical News
for LIF

Publications
for LIF

Search for LIF

Genome Databases showing LIF

Other Databases showing LIF

Specialized Databases showing LIF

Licensable Technologies
for LIF

Services
for LIF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LIF Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor LIF

Summariesfor LIF

Genomic Locationfor LIF

Proteinsfor LIF

Protein Domains/Familiesfor LIF

Gene Functionfor LIF

Pathways & Interactionsfor LIF

Drugs & Compoundsfor LIF

Transcriptsfor LIF

Expression for LIF

Orthologsfor LIF

Paralogsfor LIF

SNPs/Variantsfor LIF

Disorders & Mutationsfor LIF

Medical Newsfor LIF

Publicationsfor LIF

Search for LIF

Genome Databases showing LIF

Other Databases showing LIF

Specialized Databases showing LIF

Licensable Technologiesfor LIF

Servicesfor LIF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LIF

Summaries
for LIF

Genomic Location
for LIF

Proteins
for LIF

Protein Domains/
Families
for LIF

Gene Function
for LIF

Pathways & Interactions
for LIF

Drugs & Compounds
for LIF

Transcripts
for LIF

Expression
for LIF

Orthologs
for LIF

Paralogs
for LIF

SNPs/Variants
for LIF

Disorders & Mutations
for LIF

Medical News
for LIF

Publications
for LIF

Licensable Technologies
for LIF

Services
for LIF