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LIF Gene

protein-coding   GIFtS: 65
GCID: GC22M030636

Leukemia Inhibitory Factor

  See LIF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukemia Inhibitory Factor1 2     Differentiation-Stimulating Factor2 3
HILDA2 3 5     Melanoma-Derived LPL Inhibitor2 3
Cholinergic Differentiation Factor1 2     MLPLI2 3
Differentiation Inhibitory Activity1 2     D Factor2 3
Differentiation-Inducing Factor1 2     CDF2
Hepatocyte-Stimulating Factor III1 2     DIA2
Human Interleukin In DA Cells1 2     Emfilermin3

External Ids:    HGNC: 65961   Entrez Gene: 39762   Ensembl: ENSG000001283427   OMIM: 1595405   UniProtKB: P150183   

Export aliases for LIF gene to outside databases

Previous GC identifers: GC22M027332 GC22M028960 GC22M013598


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LIF Gene:
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved
in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal
cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also
have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for LIF Gene:
LIF (leukemia inhibitory factor) is a protein-coding gene. Diseases associated with LIF include stachybotrys chartarum, and complement deficiency. GO annotations related to this gene include growth factor activity and receptor binding.

UniProtKB/Swiss-Prot: LIF_HUMAN, P15018
Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the
induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell
differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes

Gene Wiki entry for LIF (Leukemia inhibitory factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LIF gene promoter:
         STAT1   ATF-2   STAT1beta   STAT5A   Max   STAT3   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIF promoter sequence
   Search Chromatin IP Primers for LIF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

LIF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIF gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M030636:  view genomic region     (about GC identifiers)

Start:
30,636,436 bp from pter      End:
30,642,840 bp from pter
Size:
6,405 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LIF_HUMAN, P15018 (See protein sequence)
Recommended Name: Leukemia inhibitory factor precursor  
Size: 202 amino acids; 22008 Da
3 PDB 3D structures from and Proteopedia for LIF:
1EMR (3D)        1PVH (3D)        2Q7N (3D)    
Secondary accessions: B2RCW7 B5MC23 Q52LZ2
Alternative splicing: 2 isoforms:  P15018-1   P15018-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LIF: NX_P15018

Explore proteomics data for LIF at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn31, Asn56, Asn85, Asn95, Asn118, Asn138

  • See LIF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001244064.1  NP_002300.1  

    ENSEMBL proteins: 
     ENSP00000249075   ENSP00000384450  

    LIF Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant LIF Protein
    R&D Systems Recombinant & Natural Proteins for LIF
    Enzo Life Sciences proteins for LIF
    OriGene Purified Proteins for LIF
    OriGene Protein Over-expression Lysate for LIF
    OriGene MassSpec for LIF
    OriGene Custom Protein Services for LIF
    GenScript Purified and Recombinant Proteins for LIF
    Novus Biologicals LIF Proteins
    Novus Biologicals LIF Lysates
    Sino Biological Recombinant Protein for LIF
    Sino Biological Cell Lysate for LIF
    ProSpec Recombinant Protein for LIF
    Cloud-Clone Corp. Proteins for LIF

     
    eBioscience Proteins for LIF: (see all 2
                        Human LIF Recombinant Protein Carrier-Free 100 ug

     
    antibodies-online proteins for LIF (88 products) 

     
    antibodies-online peptides for LIF

    LIF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LIF
    R&D Systems Antibodies for LIF
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    Novus Biologicals LIF Antibodies
    Abcam antibodies for LIF
    Cloud-Clone Corp. Antibodies for LIF
    ThermoFisher Antibodies for LIF
    antibodies-online antibodies for LIF (70 products) 

    LIF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LIF
    R&D Systems ELISAs for LIF         (see all)
    GenScript Custom Assay Services for LIF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LIF
    Cloud-Clone Corp. CLIAs for LIF
    eBioscience ELISAs for LIF:  
                        Human LIF Platinum ELISA 96 tests
    antibodies-online kits for LIF (37 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR009079 4_helix_cytokine-like_core
     IPR003624 Leukemia_IF
     IPR012351 4_helix_cytokine_core
     IPR019827 Leukemia_IF/oncostatin_CS
     IPR001581 Leukemia_IF/oncostatin

    Graphical View of Domain Structure for InterPro Entry P15018

    ProtoNet protein and cluster: P15018

    1 Blocks protein domain: IPB003624 Leukemia inhibitory factor

    UniProtKB/Swiss-Prot: LIF_HUMAN, P15018
    Similarity: Belongs to the LIF/OSM family


    Find genes that share domains with LIF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIF_HUMAN, P15018
    Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the
    induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell
    differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes

         Genatlas biochemistry entry for LIF:
    leukemia inhibitory factor (differentiation-stimulating factor),interleukin-6 cytokine family member stimulating
    hematopoiesis,platelet production,localized distally to the breakpoint in t(11;22)(q24;q12)

         Summary: 
    During embryonic development, LIF as signaling molecule affects the following cells:
    Eye: Late Retinal Progenitor Cells (Retinal Neuroblastic Layer)

    LIF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 4)      
    Gonad: Human oogonial stem cells, Human oogonial stem cells (Mm)       to see all 2 cells
    Ovary: Oocytes (Mm), Oocytes       to see all 2 cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001135RNA polymerase II transcription factor recruiting transcription factor activity IDA--
    GO:0005102receptor binding IPI8999038
    GO:0005125cytokine activity IDA7957045
    GO:0005146leukemia inhibitory factor receptor binding IPI8999038
    GO:0008083growth factor activity IDA12643274
         
    Find genes that share ontologies with LIF           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for LIF:
     Decreased G3BP1 protein expres  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Increased HDAC inhibitor resis 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lif) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with LIF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LIF: Liftm1Cgre Liftm1Stw

       genOway: Develop your customized and physiologically relevant rodent model for LIF

    miRNA
    Products:
        
    miRTarBase miRNAs that target LIF:
    hsa-mir-26b-5p (MIRT029582), hsa-mir-335-5p (MIRT018057), hsa-mir-125a-5p (MIRT004326), hsa-mir-26a-5p (MIRT001039), hsa-mir-346 (MIRT001040), hsa-mir-223-3p (MIRT006248), hsa-mir-199a-5p (MIRT004325), hsa-mir-330-5p (MIRT038243), hsa-mir-125b-5p (MIRT001037)

    Block miRNA regulation of human, mouse, rat LIF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIF (see all 91):
    hsa-miR-520e hsa-miR-520f hsa-miR-3194-5p hsa-miR-106a hsa-miR-1224-3p hsa-miR-3921 hsa-miR-3916 hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LIF
    Predesigned siRNA for gene silencing in human, mouse, rat LIF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LIF

    Clone
    Products:
         
    OriGene clones in human, mouse for LIF (see all 7)
    OriGene ORF clones in mouse, rat for LIF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIF (NM_002309)
    Sino Biological Human cDNA Clone for LIF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LIF
    Browse ESI BIO Cell Lines and PureStem Progenitors for LIF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIF_HUMAN, P15018: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IC12643274
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with LIF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LIF About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    MIF Mediated Glucocorticoid Regulation0.94
    STAT3 Pathway0.47
    PEDF Induced Signaling0.73
    Endothelin-1 Signaling Pathway0.46
    all-trans-Retinoic Acid Signaling in Brain0.71
    Cytokine-cytokine receptor interaction0.43
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    4PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56
    5NFAT and Cardiac Hypertrophy
    NFAT and Cardiac Hypertrophy0.42
    Signaling Involved in Cardiac Hypertrophy0.42


    Find genes that share SuperPaths with LIF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LIF (see all 18)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    ERK5 Signaling
    Signaling Involved in Cardiac Hypertrophy

    5 BioSystems Pathways for LIF
        MicroRNAs in cardiomyocyte hypertrophy
    TGF Beta Signaling Pathway
    Adipogenesis
    Direct p53 effectors
    Validated transcriptional targets of AP1 family members Fra1 and Fra2



    3 Kegg Pathways  (Kegg details for LIF):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LIF (see all 10): 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LIF

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for LIF (P150182, 3 ENSP000002490754) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIFRP427022, 3, ENSP000002634094MINT-62477 MINT-62475 I2D: score=4 STRING: ENSP00000263409
    IL6STP401892, 3, ENSP000003387994MINT-62483 I2D: score=5 STRING: ENSP00000338799
    CNTFRP269923I2D: score=1 
    JUNENSP000003602664STRING: ENSP00000360266
    TP53ENSP000002693054STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001974blood vessel remodeling IEA--
    GO:0006366transcription from RNA polymerase II promoter IDA--
    GO:0006955immune response IEA--
    GO:0007275multicellular organismal development TAS3143918
    GO:0007566embryo implantation IEA--

    Find genes that share ontologies with LIF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LIF

    UniProtKB/Swiss-Prot: LIF_HUMAN, P15018
    Pharmaceutical: In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in
    women who have failed to become pregnant despite assisted reproductive technologies (ART)

    Selected Novoseek inferred chemical compound relationships for LIF gene (see all 107)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gp 130 95.4 406 12799551 (5), 9568895 (5), 9712900 (5), 12574225 (4) (see all 99)
    toxohormone-l 65.8 2 7622421 (1), 8765417 (1)
    il 11 61.8 5 19647472 (2), 8605875 (1)
    tyrosine 53 49 8900046 (3), 18174171 (2), 8174677 (2), 7688764 (2) (see all 34)
    progesterone 47 77 9835355 (5), 16055453 (4), 18675966 (3), 11574494 (3) (see all 37)
    tgf beta1 44.5 13 9714521 (2), 14968036 (2), 17034864 (1), 14627547 (1) (see all 9)
    pd 98,059 40.4 7 10217263 (1), 12145097 (1), 19340839 (1), 18252965 (1) (see all 6)
    rantes 37.6 15 12620497 (2), 8626989 (2), 15708128 (1), 9764576 (1) (see all 10)
    gm-csf 37.1 2 8769977 (1), 7683736 (1)
    onapristone 34.7 3 11420216 (2)



    Find genes that share compounds with LIF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LIF gene (2 alternative transcripts): 
    NM_001257135.1  NM_002309.4  

    Unigene Cluster for LIF:

    Leukemia inhibitory factor
    Hs.2250  [show with all ESTs]
    Unigene Representative Sequence: NM_002309
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249075(uc003agz.2 uc011aks.1) ENST00000403987
    miRNA
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    Block miRNA regulation of human, mouse, rat LIF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIF (see all 91):
    hsa-miR-520e hsa-miR-520f hsa-miR-3194-5p hsa-miR-106a hsa-miR-1224-3p hsa-miR-3921 hsa-miR-3916 hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: LIF (NM_002309)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIF
    Primer
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    OriGene qPCR primer pairs and template standards for LIF
    OriGene qSTAR qPCR primer pairs in human, mouse for LIF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LIF
      QuantiTect SYBR Green Assays in human, mouse, rat LIF
      QuantiFast Probe-based Assays in human, mouse, rat LIF

    Additional mRNA sequence: 

    AK315310.1 BC069540.1 BC093733.1 BC093735.1 BC143305.1 X13967.1 

    3 DOTS entries:

    DT.210986  DT.100744740  DT.91970156 

    Selected AceView cDNA sequences (see all 47):

    BU175373 BM129796 CK819709 BC069540 R50018 AL711919 H55709 CD614554 
    BM561741 BU197122 BE349408 BP366214 BX099968 NM_002309 BQ691666 CB217076 
    AI889752 X13967 CA430261 AI983629 W46451 CB216985 BE733152 AI570795 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LIF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTGGGTG
    LIF Expression
    About this image


    LIF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 3 entries
             Zygote Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 3 entries
             Zygote Zygote
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
             Zygote Zygote
     
     Epidermis (Integumentary System)
             MSC-containing human skin substitute (Grafix)
     
     Adipose (Muscoskeletal System)
             Visceral White Preadipocytes Visceral White Adipose
    LIF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LIF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2250
        Pathway & Disease-focused RT2 Profiler PCR Arrays including LIF (see all 10): 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LIF
    OriGene qSTAR qPCR primer pairs in human, mouse for LIF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LIF
    QuantiTect SYBR Green Assays in human, mouse, rat LIF
    QuantiFast Probe-based Assays in human, mouse, rat LIF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LIF gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lif1 , 5 leukemia inhibitory factor1, 5 81.19(n)1
    80.2(a)1
      11 (2.94 cM)5
    168781  NM_008501.21  NP_032527.11 
     42575575 
    chicken
    (Gallus gallus)
    Aves LIF1 leukemia inhibitory factor 59.83(n)
    43.59(a)
      427718  XM_425293.4  XP_425293.4 


    ENSEMBL Gene Tree for LIF (if available)
    TreeFam Gene Tree for LIF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LIF (see all 192)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57639081,2
    C,F--14558289(+) acctcC/Ttggga 2 -- ds50011Minor allele frequency- T:0.07EA 120
    rs1914823011,2
    --14558322(+) CACCCC/TGAGTA 2 -- ds50010--------
    rs601013771,2
    C,F--14558472(+) ACAGGA/TGTGAC 2 -- ds50012Minor allele frequency- T:0.04WA 120
    rs15578331,2
    C,F,A,H--14558618(+) CCCTCA/CCCCAC 2 -- ds500112Minor allele frequency- C:0.45EA NS NA WA CSA 1963
    rs1823884961,2
    --14558639(+) CCTTCA/GCTGAG 2 -- ds50010--------
    rs778807771,2
    --14558739(+) GTAGAA/TTCTTT 2 -- ut310--------
    rs1880500601,2
    --14558821(+) CATTGA/TATAAA 2 -- ut310--------
    rs1501681841,2
    C--14558968(+) AGCACA/GTGGGC 2 -- ut310--------
    rs96067061,2
    C,F--14558993(+) GATGCC/G/TGGGAT 4 -- ut31 ese34NA CSA EA 243
    rs1386741221,2
    --14559404(+) CTGTGC/TAGGGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LIF (30636436 - 30642840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LIF:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4954n71CNV Loss21882294
    nsv829171CNV Loss20364138
    dgv4955n71CNV Loss21882294
    nsv914970CNV Loss21882294
    nsv834173CNV Loss17160897
    esv995861CNV Gain20482838
    nsv834174CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): LIF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LIF
    DNA2.0 Custom Variant and Variant Library Synthesis for LIF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159540    OMIM disorders: --

    10 diseases for LIF:    
    About MalaCards
    stachybotrys chartarum    complement deficiency    neuroepithelioma    acth-secreting pituitary adenoma
    histiocytosis    pregnancy loss    meningococcemia    myeloid leukemia
    leukemia    malaria


    Find genes that share disorders with LIF           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LIF gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 94.9 2672 10212267 (7), 9822513 (7), 8987949 (7), 18240017 (6) (see all 99)
    necrosis 54.1 147 8313662 (2), 8137298 (2), 7760346 (2), 16477612 (2) (see all 99)
    myeloid leukemia 52.3 20 1908551 (2), 8564713 (1), 8462021 (1), 8632998 (1) (see all 13)
    miscarriage recurrent 52.1 18 16126674 (3), 9734394 (3), 17034864 (1), 17156190 (1) (see all 8)
    abortion inevitable 51.5 20 16640878 (4), 11930689 (3)
    response acute phase 51 11 1714773 (2), 1281789 (1), 12773095 (1), 1718962 (1) (see all 9)
    neuroepithelioma 46.4 5 7622421 (1), 8765417 (1), 14647442 (1)
    complement deficiency 44.8 1 7660072 (1)
    infertility 43.2 57 9506211 (4), 14687743 (4), 19545488 (4), 11783352 (3) (see all 26)
    choriocarcinoma 42.7 6 16125646 (1), 8833034 (1), 12606473 (1), 15837065 (1) (see all 5)

    Genetic Association Database (GAD): LIF
    Human Genome Epidemiology (HuGE) Navigator: LIF (25 documents)
    Tumor Gene Database (TGDB): LIF

    Export disorders for LIF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LIF gene, integrated from 10 sources (see all 1216):
    (articles sorted by number of sources associating them with LIF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Leukaemia inhibitory factor (LIF) gene mutations in women diagnosed with unexplained infertility and endometriosis have a negative impact on the IVF outcome. A pilot study. (PubMed id 19545488)1, 4, 9 NovotnA1 Z....KrA!lA-ckovA! M. (Folia Biol. (Praha) 2009)
    2. [The leukemia inhibitory factor gene mutations in the population of infertile women: the heterozygote transition G to A on the position 3400 does not affect the outcome of the infertility treatment]. (PubMed id 17966612)1, 4, 9 KrA!lA-ckovA! M....Hes O. (Ceska Gynekol 2007)
    3. An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. (PubMed id 17652170)1, 2, 9 Huyton T....Garrett T.P. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    4. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (PubMed id 14527405)1, 2, 9 Boulanger M.J.... Garcia K.C. (Mol. Cell 2003)
    5. Neuropoietic cytokines in the hematopoietic fold. (PubMed id 1714745)1, 3, 9 Bazan J.F. (Neuron 1991)
    6. Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. (PubMed id 19470478)1, 4, 9 Kang H.J....Hu W. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    7. Study of leukemia inhibitory factor polymorphism within an Australian multiple sclerosis population. (PubMed id 19251277)1, 4, 9 Mackenzie J....Griffiths L.R. (J. Neurol. Sci. 2009)
    8. Association of the leukemia inhibitory factor gene mutation and the antiphospholipid antibodies in the peripheral blood of infertile women. (PubMed id 18298054)1, 4, 9 KrA!lA-ckovA! M....Vetvicka V. (Folia Microbiol. (Praha) 2007)
    9. No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis. (PubMed id 16263181)1, 4, 9 Vanderlocht J....Hellings N. (J. Neuroimmunol. 2006)
    10. Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene. (PubMed id 11587067)1, 4, 9 Ishida R....Emi M. (J. Hum. Genet. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3976 HGNC: 6596 AceView: LIF Ensembl:ENSG00000128342 euGenes: HUgn3976
    ECgene: LIF Kegg: 3976 H-InvDB: LIF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LIF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LIF Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Leukemia_inhibitory_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LIF gene:
    Search GeneIP for patents involving LIF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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