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Aliases for LIF Gene

Aliases for LIF Gene

  • Leukemia Inhibitory Factor 2 3 5
  • Differentiation Inhibitory Activity 2 3
  • Cholinergic Differentiation Factor 2 3
  • Differentiation-Stimulating Factor 3 4
  • Hepatocyte-Stimulating Factor III 2 3
  • Differentiation-Inducing Factor 2 3
  • Melanoma-Derived LPL Inhibitor 3 4
  • Human Interleukin In DA Cells 2 3
  • D Factor 3 4
  • HILDA 3 4
  • MLPLI 3 4
  • Emfilermin 4
  • DIA 3
  • CDF 3

External Ids for LIF Gene

Previous GeneCards Identifiers for LIF Gene

  • GC22M027332
  • GC22M028960
  • GC22M030636
  • GC22M013598

Summaries for LIF Gene

Entrez Gene Summary for LIF Gene

  • The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for LIF Gene

LIF (Leukemia Inhibitory Factor) is a Protein Coding gene. Diseases associated with LIF include Leukemia and Ectopic Pregnancy. Among its related pathways are Immune System and PEDF Induced Signaling. GO annotations related to this gene include receptor binding and growth factor activity.

UniProtKB/Swiss-Prot for LIF Gene

  • LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Gene Wiki entry for LIF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIF Gene

Genomics for LIF Gene

Regulatory Elements for LIF Gene

Enhancers for LIF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F030181 1.3 FANTOM5 Ensembl ENCODE 21.3 +74.2 74196 4.3 HDAC1 PKNOX1 TBL1XR1 GATA2 KLF16 SMARCA4 PBX2 IKZF1 HMBOX1 ZNF24 LIF ASCC2 HORMAD2-AS1 LOC105372988 ENSG00000232530 MTMR3 DUSP18 OSM SF3A1 RPS3AP51
GH22F030275 0.8 FANTOM5 Ensembl ENCODE 19 -20.1 -20078 4.8 ATF1 ZNF121 GLIS2 CREM EGR2 ZNF362 NR2F2 SMARCA4 ZNF341 GLIS1 OSM LIF TBC1D10A ENSG00000248751 SEC14L2 ENSG00000232530 ENSG00000249590 SLC35E4 SEC14L4 RNF215
GH22F030159 0.6 FANTOM5 17.6 +98.6 98574 0.1 CTCF NFE2 RAD21 LIF LOC105372988 ENSG00000232530 GATSL3 RPS3AP51
GH22F030160 0.7 Ensembl ENCODE 16.6 +97.9 97907 0.9 CTCF MAFG CEBPB CEBPG RAD21 ZNF316 MAFF CEBPA NFE2 FOS LIF LOC105372988 ENSG00000232530 GATSL3 RPS3AP51
GH22F030153 0.3 FANTOM5 16.2 +104.2 104219 0.1 LIF LOC105372988 ENSG00000232530 GATSL3 RPS3AP51
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LIF on UCSC Golden Path with GeneCards custom track

Genomic Location for LIF Gene

Chromosome:
22
Start:
30,240,447 bp from pter
End:
30,257,923 bp from pter
Size:
17,477 bases
Orientation:
Minus strand

Genomic View for LIF Gene

Genes around LIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIF Gene

Proteins for LIF Gene

  • Protein details for LIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15018-LIF_HUMAN
    Recommended name:
    Leukemia inhibitory factor
    Protein Accession:
    P15018
    Secondary Accessions:
    • B2RCW7
    • B5MC23
    • Q52LZ2

    Protein attributes for LIF Gene

    Size:
    202 amino acids
    Molecular mass:
    22008 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LIF Gene

    Alternative splice isoforms for LIF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIF Gene

Post-translational modifications for LIF Gene

  • Glycosylation at Asn 31, Asn 56, Asn 85, Asn 95, Asn 118, and Asn 138

Other Protein References for LIF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LIF Gene

Domains & Families for LIF Gene

Suggested Antigen Peptide Sequences for LIF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15018

UniProtKB/Swiss-Prot:

LIF_HUMAN :
  • Belongs to the LIF/OSM family.
Family:
  • Belongs to the LIF/OSM family.
genes like me logo Genes that share domains with LIF: view

Function for LIF Gene

Molecular function for LIF Gene

GENATLAS Biochemistry:
leukemia inhibitory factor (differentiation-stimulating factor),interleukin-6 cytokine family member stimulating hematopoiesis,platelet production,localized distally to the breakpoint in t(11;22)(q24;q12)
UniProtKB/Swiss-Prot Function:
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

LifeMap Function Summary for LIF Gene

LIF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IDA 22783022
GO:0005102 receptor binding IPI 8999038
GO:0005125 cytokine activity IEA,IDA 7957045
GO:0005146 leukemia inhibitory factor receptor binding IEA,IPI 8999038
GO:0005515 protein binding IPI 14527405
genes like me logo Genes that share ontologies with LIF: view
genes like me logo Genes that share phenotypes with LIF: view

Animal Models for LIF Gene

MGI Knock Outs for LIF:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIF Gene

Localization for LIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIF Gene COMPARTMENTS Subcellular localization image for LIF gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 3
cytoskeleton 2
nucleus 2
vacuole 1

Gene Ontology (GO) - Cellular Components for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IC 12643274
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with LIF: view

Pathways & Interactions for LIF Gene

genes like me logo Genes that share pathways with LIF: view

SIGNOR curated interactions for LIF Gene

Activates:

Gene Ontology (GO) - Biological Process for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0006955 immune response IEA --
GO:0007275 multicellular organism development TAS 3143918
GO:0007566 embryo implantation IEA --
GO:0008284 positive regulation of cell proliferation IDA,TAS 7957045
genes like me logo Genes that share ontologies with LIF: view

Drugs & Compounds for LIF Gene

(54) Drugs for LIF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(53) Additional Compounds for LIF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LIF: view

Transcripts for LIF Gene

mRNA/cDNA for LIF Gene

Unigene Clusters for LIF Gene

Leukemia inhibitory factor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIF Gene

No ASD Table

Relevant External Links for LIF Gene

GeneLoc Exon Structure for
LIF
ECgene alternative splicing isoforms for
LIF

Expression for LIF Gene

mRNA expression in normal human tissues for LIF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIF Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.6) and Prostate (x4.4).

Protein differential expression in normal tissues from HIPED for LIF Gene

This gene is overexpressed in Cerebrospinal fluid (57.7) and Bone marrow mesenchymal stem cell (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIF Gene



Protein tissue co-expression partners for LIF Gene

NURSA nuclear receptor signaling pathways regulating expression of LIF Gene:

LIF

SOURCE GeneReport for Unigene cluster for LIF Gene:

Hs.2250
genes like me logo Genes that share expression patterns with LIF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LIF Gene

Orthologs for LIF Gene

This gene was present in the common ancestor of chordates.

Orthologs for LIF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIF 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia LIF 34 35
  • 91.91 (n)
cow
(Bos Taurus)
Mammalia LIF 34 35
  • 88.61 (n)
rat
(Rattus norvegicus)
Mammalia Lif 34
  • 82.34 (n)
mouse
(Mus musculus)
Mammalia Lif 34 16 35
  • 81.19 (n)
oppossum
(Monodelphis domestica)
Mammalia LIF 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIF 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIF 34 35
  • 59.83 (n)
Species where no ortholog for LIF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LIF Gene

ENSEMBL:
Gene Tree for LIF (if available)
TreeFam:
Gene Tree for LIF (if available)

Paralogs for LIF Gene

No data available for Paralogs for LIF Gene

Variants for LIF Gene

Sequence variations from dbSNP and Humsavar for LIF Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111276896 -- 30,247,937(+) TCTGG(A/G)GCCAT upstream-variant-2KB
rs111330617 -- 30,245,044(+) CCTGG(A/T)TCCCC intron-variant, upstream-variant-2KB
rs111876632 -- 30,240,783(+) GAAAT(C/G)CTACC utr-variant-3-prime
rs112508406 -- 30,246,709(+) GCACT(G/T)CAGAG nc-transcript-variant, utr-variant-5-prime
rs112776523 -- 30,243,999(+) AAGTC(C/G/T)GTCAC reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for LIF Gene

Variant ID Type Subtype PubMed ID
esv995861 CNV gain 20482838
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv834173 CNV loss 17160897
nsv834174 CNV gain+loss 17160897

Variation tolerance for LIF Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIF Gene

Human Gene Mutation Database (HGMD)
LIF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIF Gene

Disorders for LIF Gene

MalaCards: The human disease database

(15) MalaCards diseases for LIF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia
ectopic pregnancy
  • eccyesis
complement deficiency
  • complement deficiency disease
null-cell leukemia
  • null cell acute lymphoblastic leukemia
stachybotrys chartarum
  • stachybotrys atra
- elite association - COSMIC cancer census association via MalaCards
Search LIF in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIF

Genetic Association Database (GAD)
LIF
Human Genome Epidemiology (HuGE) Navigator
LIF
Tumor Gene Database (TGDB):
LIF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIF
genes like me logo Genes that share disorders with LIF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIF Gene

Publications for LIF Gene

  1. An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. (PMID: 17652170) Huyton T. … Garrett T.P. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 22 64
  2. Association of the leukemia inhibitory factor gene mutation and the antiphospholipid antibodies in the peripheral blood of infertile women. (PMID: 18298054) KrA!lA-ckovA! M. … Vetvicka V. (Folia Microbiol. (Praha) 2007) 3 22 46 64
  3. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (PMID: 14527405) Boulanger M.J. … Garcia K.C. (Mol. Cell 2003) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64

Products for LIF Gene

Sources for LIF Gene

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