Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LIF Gene

Aliases for LIF Gene

  • Leukemia Inhibitory Factor 2 3 5
  • Differentiation Inhibitory Activity 2 3
  • Cholinergic Differentiation Factor 2 3
  • Differentiation-Stimulating Factor 3 4
  • Hepatocyte-Stimulating Factor III 2 3
  • Differentiation-Inducing Factor 2 3
  • Melanoma-Derived LPL Inhibitor 3 4
  • Human Interleukin In DA Cells 2 3
  • D Factor 3 4
  • HILDA 3 4
  • MLPLI 3 4
  • Emfilermin 4
  • DIA 3
  • CDF 3

External Ids for LIF Gene

Previous GeneCards Identifiers for LIF Gene

  • GC22M027332
  • GC22M028960
  • GC22M030636
  • GC22M013598

Summaries for LIF Gene

Entrez Gene Summary for LIF Gene

  • The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for LIF Gene

LIF (Leukemia Inhibitory Factor) is a Protein Coding gene. Diseases associated with LIF include Premature Ovarian Failure and Leukemia. Among its related pathways are PEDF Induced Signaling and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include receptor binding and growth factor activity.

UniProtKB/Swiss-Prot for LIF Gene

  • LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Gene Wiki entry for LIF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIF Gene

Genomics for LIF Gene

Regulatory Elements for LIF Gene

Enhancers for LIF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LIF on UCSC Golden Path with GeneCards custom track

Genomic Location for LIF Gene

Chromosome:
22
Start:
30,240,447 bp from pter
End:
30,257,923 bp from pter
Size:
17,477 bases
Orientation:
Minus strand

Genomic View for LIF Gene

Genes around LIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIF Gene

Proteins for LIF Gene

  • Protein details for LIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15018-LIF_HUMAN
    Recommended name:
    Leukemia inhibitory factor
    Protein Accession:
    P15018
    Secondary Accessions:
    • B2RCW7
    • B5MC23
    • Q52LZ2

    Protein attributes for LIF Gene

    Size:
    202 amino acids
    Molecular mass:
    22008 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LIF Gene

    Alternative splice isoforms for LIF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIF Gene

Post-translational modifications for LIF Gene

  • Glycosylation at Asn 31, Asn 56, Asn 85, Asn 95, Asn 118, and Asn 138

Other Protein References for LIF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for LIF Gene

Domains & Families for LIF Gene

Suggested Antigen Peptide Sequences for LIF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15018

UniProtKB/Swiss-Prot:

LIF_HUMAN :
  • Belongs to the LIF/OSM family.
Family:
  • Belongs to the LIF/OSM family.
genes like me logo Genes that share domains with LIF: view

Function for LIF Gene

Molecular function for LIF Gene

GENATLAS Biochemistry:
leukemia inhibitory factor (differentiation-stimulating factor),interleukin-6 cytokine family member stimulating hematopoiesis,platelet production,localized distally to the breakpoint in t(11;22)(q24;q12)
UniProtKB/Swiss-Prot Function:
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Gene Ontology (GO) - Molecular Function for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IDA 22783022
GO:0005102 receptor binding IPI 8999038
GO:0005125 cytokine activity IDA 7957045
GO:0005146 leukemia inhibitory factor receptor binding IPI 8999038
GO:0005515 protein binding IPI 14527405
genes like me logo Genes that share ontologies with LIF: view
genes like me logo Genes that share phenotypes with LIF: view

Animal Models for LIF Gene

MGI Knock Outs for LIF:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIF Gene

Localization for LIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIF Gene COMPARTMENTS Subcellular localization image for LIF gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 3
cytoskeleton 2
nucleus 2
vacuole 1

Gene Ontology (GO) - Cellular Components for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IC 12643274
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with LIF: view

Pathways & Interactions for LIF Gene

genes like me logo Genes that share pathways with LIF: view

SIGNOR curated interactions for LIF Gene

Activates:

Gene Ontology (GO) - Biological Process for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0006955 immune response IEA --
GO:0007275 multicellular organism development TAS 3143918
GO:0007566 embryo implantation IEA --
GO:0008284 positive regulation of cell proliferation IDA 7957045
genes like me logo Genes that share ontologies with LIF: view

Drugs & Compounds for LIF Gene

(54) Drugs for LIF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(53) Additional Compounds for LIF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LIF: view

Transcripts for LIF Gene

mRNA/cDNA for LIF Gene

Unigene Clusters for LIF Gene

Leukemia inhibitory factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIF Gene

No ASD Table

Relevant External Links for LIF Gene

GeneLoc Exon Structure for
LIF
ECgene alternative splicing isoforms for
LIF

Expression for LIF Gene

mRNA expression in normal human tissues for LIF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIF Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.6) and Prostate (x4.4).

Protein differential expression in normal tissues from HIPED for LIF Gene

This gene is overexpressed in Cerebrospinal fluid (57.7) and Bone marrow mesenchymal stem cell (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIF Gene



Protein tissue co-expression partners for LIF Gene

NURSA nuclear receptor signaling pathways regulating expression of LIF Gene:

LIF

SOURCE GeneReport for Unigene cluster for LIF Gene:

Hs.2250
genes like me logo Genes that share expression patterns with LIF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LIF Gene

Orthologs for LIF Gene

This gene was present in the common ancestor of chordates.

Orthologs for LIF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LIF 34
  • 88.61 (n)
  • 89.11 (a)
LIF 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIF 34
  • 91.91 (n)
  • 92.08 (a)
LIF 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lif 34
  • 81.19 (n)
  • 80.2 (a)
Lif 16
Lif 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LIF 34
  • 99.83 (n)
  • 100 (a)
LIF 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lif 34
  • 82.34 (n)
  • 81.19 (a)
oppossum
(Monodelphis domestica)
Mammalia LIF 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIF 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIF 34
  • 59.83 (n)
  • 43.59 (a)
LIF 35
  • 37 (a)
OneToOne
Species where no ortholog for LIF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LIF Gene

ENSEMBL:
Gene Tree for LIF (if available)
TreeFam:
Gene Tree for LIF (if available)

Paralogs for LIF Gene

No data available for Paralogs for LIF Gene

Variants for LIF Gene

Sequence variations from dbSNP and Humsavar for LIF Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs715605 -- 30,244,319(-) TTCCC(C/T)TCTGT intron-variant
rs737812 -- 30,243,121(+) GACAG(A/C)CTTCC utr-variant-3-prime
rs737921 -- 30,244,225(+) TAATT(A/G)TAATG intron-variant
rs757301 -- 30,253,443(+) CCCCC(A/C/G)CTCCA intron-variant
rs5997598 -- 30,242,102(+) GGGAC(A/G)CAGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LIF Gene

Variant ID Type Subtype PubMed ID
esv995861 CNV gain 20482838
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv834173 CNV loss 17160897
nsv834174 CNV gain+loss 17160897

Variation tolerance for LIF Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIF Gene

Human Gene Mutation Database (HGMD)
LIF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIF Gene

Disorders for LIF Gene

MalaCards: The human disease database

(15) MalaCards diseases for LIF Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
premature ovarian failure
  • hypergonadotropic hypogonadism
leukemia
ectopic pregnancy
  • eccyesis
cerebral meningioma
  • meningioma of cerebrum
null-cell leukemia
  • null cell acute lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search LIF in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIF

Genetic Association Database (GAD)
LIF
Human Genome Epidemiology (HuGE) Navigator
LIF
Tumor Gene Database (TGDB):
LIF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIF
genes like me logo Genes that share disorders with LIF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIF Gene

Publications for LIF Gene

  1. An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. (PMID: 17652170) Huyton T. … Garrett T.P. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 22 65
  2. Association of the leukemia inhibitory factor gene mutation and the antiphospholipid antibodies in the peripheral blood of infertile women. (PMID: 18298054) KrA!lA-ckovA! M. … Vetvicka V. (Folia Microbiol. (Praha) 2007) 3 22 46 65
  3. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (PMID: 14527405) Boulanger M.J. … Garcia K.C. (Mol. Cell 2003) 3 4 22 65
  4. Leukemia inhibitory factor gene is associated with schizophrenia and working memory function. (PMID: 19879916) Okahisa Y. … Kuroda S. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2010) 3 46 65
  5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 65

Products for LIF Gene

Sources for LIF Gene

Content