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Aliases for LIF Gene

Aliases for LIF Gene

  • Leukemia Inhibitory Factor 2 3
  • HILDA 3 4 6
  • Differentiation Inhibitory Activity 2 3
  • Cholinergic Differentiation Factor 2 3
  • Differentiation-Stimulating Factor 3 4
  • Hepatocyte-Stimulating Factor III 2 3
  • Differentiation-Inducing Factor 2 3
  • Melanoma-Derived LPL Inhibitor 3 4
  • Human Interleukin In DA Cells 2 3
  • D Factor 3 4
  • MLPLI 3 4
  • Emfilermin 4
  • CDF 3
  • DIA 3

External Ids for LIF Gene

Previous GeneCards Identifiers for LIF Gene

  • GC22M027332
  • GC22M028960
  • GC22M030636
  • GC22M013598

Summaries for LIF Gene

Entrez Gene Summary for LIF Gene

  • The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for LIF Gene

LIF (Leukemia Inhibitory Factor) is a Protein Coding gene. Diseases associated with LIF include stachybotrys chartarum and complement deficiency. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and growth factor activity.

UniProtKB/Swiss-Prot for LIF Gene

  • LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes

Gene Wiki entry for LIF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIF Gene

Genomics for LIF Gene

Regulatory Elements for LIF Gene

Genomic Location for LIF Gene

Start:
30,240,447 bp from pter
End:
30,257,381 bp from pter
Size:
16,935 bases
Orientation:
Minus strand

Genomic View for LIF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIF Gene

Proteins for LIF Gene

  • Protein details for LIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15018-LIF_HUMAN
    Recommended name:
    Leukemia inhibitory factor
    Protein Accession:
    P15018
    Secondary Accessions:
    • B2RCW7
    • B5MC23
    • Q52LZ2

    Protein attributes for LIF Gene

    Size:
    202 amino acids
    Molecular mass:
    22008 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for LIF Gene

    Alternative splice isoforms for LIF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIF Gene

Proteomics data for LIF Gene at MOPED

Post-translational modifications for LIF Gene

  • Glycosylation at Asn31, Asn56, Asn85, Asn95, Asn118, and Asn138

Other Protein References for LIF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LIF Gene

Domains for LIF Gene

Suggested Antigen Peptide Sequences for LIF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15018

UniProtKB/Swiss-Prot:

LIF_HUMAN :
  • P15018
Family:
  • Belongs to the LIF/OSM family.
genes like me logo Genes that share domains with LIF: view

No data available for Gene Families for LIF Gene

Function for LIF Gene

Molecular function for LIF Gene

GENATLAS Biochemistry: leukemia inhibitory factor (differentiation-stimulating factor),interleukin-6 cytokine family member stimulating hematopoiesis,platelet production,localized distally to the breakpoint in t(11;22)(q24;q12)
UniProtKB/Swiss-Prot Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes

LifeMap Function Summary for LIF Gene

LIF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001135 RNA polymerase II transcription factor recruiting transcription factor activity IDA 22783022
GO:0005102 receptor binding IPI 8999038
GO:0005125 cytokine activity IDA 7957045
GO:0005146 leukemia inhibitory factor receptor binding IPI 8999038
GO:0008083 growth factor activity IDA 12643274
genes like me logo Genes that share ontologies with LIF: view
genes like me logo Genes that share phenotypes with LIF: view

Animal Models for LIF Gene

MGI Knock Outs for LIF:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LIF Gene

Localization for LIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIF Gene COMPARTMENTS Subcellular localization image for LIF gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IC 12643274
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with LIF: view

Pathways for LIF Gene

genes like me logo Genes that share pathways with LIF: view

Gene Ontology (GO) - Biological Process for LIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0006366 transcription from RNA polymerase II promoter IDA 22783022
GO:0006955 immune response IEA --
GO:0007275 multicellular organismal development TAS 3143918
GO:0007566 embryo implantation IEA --
genes like me logo Genes that share ontologies with LIF: view

Compounds for LIF Gene

UniProtKB/Swiss-Prot:

P15018-LIF_HUMAN
Pharmaceutical: In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies (ART)

(107) Novoseek inferred chemical compound relationships for LIF Gene

Compound -log(P) Hits PubMed IDs
gp 130 95.4 171
toxohormone-l 65.8 2
il 11 61.8 3
tyrosine 53 40
progesterone 47 56
genes like me logo Genes that share compounds with LIF: view

Transcripts for LIF Gene

Unigene Clusters for LIF Gene

Leukemia inhibitory factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIF Gene

No ASD Table

Relevant External Links for LIF Gene

GeneLoc Exon Structure for
LIF
ECgene alternative splicing isoforms for
LIF

Expression for LIF Gene

mRNA expression in normal human tissues for LIF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIF Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.6) and Prostate (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LIF Gene

SOURCE GeneReport for Unigene cluster for LIF Gene Hs.2250

genes like me logo Genes that share expressions with LIF: view

No data available for mRNA Expression by UniProt/SwissProt for LIF Gene

Orthologs for LIF Gene

This gene was present in the common ancestor of chordates.

Orthologs for LIF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIF 35
  • 99.83 (n)
  • 100 (a)
LIF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LIF 35
  • 88.61 (n)
  • 89.11 (a)
LIF 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIF 35
  • 91.91 (n)
  • 92.08 (a)
LIF 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lif 35
  • 81.19 (n)
  • 80.2 (a)
Lif 16
Lif 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LIF 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIF 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lif 35
  • 82.34 (n)
  • 81.19 (a)
chicken
(Gallus gallus)
Aves LIF 35
  • 59.83 (n)
  • 43.59 (a)
LIF 36
  • 37 (a)
OneToOne
Species with no ortholog for LIF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LIF Gene

ENSEMBL:
Gene Tree for LIF (if available)
TreeFam:
Gene Tree for LIF (if available)

Paralogs for LIF Gene

No data available for Paralogs for LIF Gene

Variants for LIF Gene

Sequence variations from dbSNP and Humsavar for LIF Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs715605 -- 30,244,319(-) TTCCC(C/T)TCTGT intron-variant
rs737812 -- 30,243,121(+) GACAG(A/C)CTTCC utr-variant-3-prime
rs737921 -- 30,244,225(+) TAATT(A/G)TAATG intron-variant
rs757301 -- 30,253,443(+) CCCCC(A/C/G)CTCCA intron-variant
rs929271 -- 30,242,237(+) TGGAA(G/T)CAAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LIF Gene

Variant ID Type Subtype PubMed ID
nsv834173 CNV Loss 17160897
nsv829171 CNV Loss 20364138
dgv4954n71 CNV Loss 21882294
nsv914970 CNV Loss 21882294
nsv834174 CNV Gain+Loss 17160897
dgv4955n71 CNV Loss 21882294
esv995861 CNV Gain 20482838

Relevant External Links for LIF Gene

HapMap Linkage Disequilibrium report
LIF
Human Gene Mutation Database (HGMD)
LIF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIF Gene

Disorders for LIF Gene

(91) Novoseek inferred disease relationships for LIF Gene

Disease -log(P) Hits PubMed IDs
leukemia 94.9 281
necrosis 54.1 110
myeloid leukemia 52.3 14
miscarriage recurrent 52.1 12
abortion inevitable 51.5 7

Relevant External Links for LIF

Genetic Association Database (GAD)
LIF
Human Genome Epidemiology (HuGE) Navigator
LIF
Tumor Gene Database (TGDB):
LIF
genes like me logo Genes that share disorders with LIF: view

No data available for UniProtKB/Swiss-Prot for LIF Gene

Publications for LIF Gene

  1. Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia inhibitory factor (LIF) gene. (PMID: 11587067) Ishida R. … Emi M. (J. Hum. Genet. 2001) 3 23 48
  2. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (PMID: 14527405) Boulanger M.J. … Garcia K.C. (Mol. Cell 2003) 3 4 23
  3. No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis. (PMID: 16263181) Vanderlocht J. … Hellings N. (J. Neuroimmunol. 2006) 3 23 48
  4. An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. (PMID: 17652170) Huyton T. … Garrett T.P. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 23
  5. [The leukemia inhibitory factor gene mutations in the population of infertile women: the heterozygote transition G to A on the position 3400 does not affect the outcome of the infertility treatment]. (PMID: 17966612) KrA!lA-ckovA! M. … Hes O. (Ceska Gynekol 2007) 3 23 48

Products for LIF Gene

Sources for LIF Gene

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