Aliases for LIF Gene
External Ids for LIF Gene
Previous GeneCards Identifiers for LIF Gene
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
GeneCards Summary for LIF Gene
LIF (LIF, Interleukin 6 Family Cytokine) is a Protein Coding gene. Diseases associated with LIF include Leukemia and Ectopic Pregnancy. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include receptor binding and growth factor activity.
UniProtKB/Swiss-Prot for LIF Gene
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.