Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LHX9 Gene

protein-coding   GIFtS: 50
GCID: GC01P197881

LIM homeobox 9
 Explore 3 diseases affiliated with
LHX9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LHX9    

Aliases
for LHX9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
LIM Homeobox 91 2
LIM Homeobox Protein 92 3
LIM/Homeobox Protein Lhx92

External Ids:    HGNC: 142221   Entrez Gene: 569562   Ensembl: ENSG000001433557   OMIM: 6060665   UniProtKB: Q9NQ693   

Export aliases for LHX9 gene to outside databases

Previous GC identifers: GC01P195608 GC01P193340 GC01P194348 GC01P195169 GC01P194613 GC01P196148 GC01P169037


Summaries
for LHX9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LHX9:
This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The
encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein
interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated,
suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LHX9_HUMAN, Q9NQ69
Function: Involved in gonadal development (By similarity)




Genomic Views
for LHX9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LHX9 gene promoter:
         STAT5B   Nkx2-5   E4BP4   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LHX9 promoter sequence
   Search SABiosciences Chromatin IP Primers for LHX9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.1   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q31.1

LHX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P197881:  view genomic region     (about GC identifiers)

Start:
 197,881,618 bp from pter      End:
 197,904,608 bp from pter
Size:
 22,991 bases      Orientation:
 plus strand

Proteins
for LHX9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LHX9_HUMAN, Q9NQ69 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx9  
Size: 397 amino acids; 43976 Da
Subunit: Interacts with LDB1 and LDB2 (By similarity)
Subcellular location: Nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for LHX9:
2DMQ (3D)    
Secondary accessions: Q5VUE2 Q5VUE3 Q5VUE6 Q86UH2 Q9BYU6 Q9NQ70
Alternative splicing: 4 isoforms:  Q9NQ69-1   Q9NQ69-2   Q9NQ69-3   Q9NQ69-4   

Explore the universe of human proteins at neXtProt for LHX9: NX_Q9NQ69

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQ69

    • LHX9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014434.1  NP_064589.2  

    ENSEMBL proteins: 
     ENSP00000356361   ENSP00000356360   ENSP00000453064   ENSP00000356358   ENSP00000337969  
     ENSP00000356357  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: LHX9
    OriGene Custom Protein Services for LHX9 
    GenScript Custom Purified and Recombinant Proteins Services for LHX9
    Novus Biologicals LHX9 Proteins
    Novus Biologicals LHX9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LHX9

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    LHX9 for ontologies           About GeneDecksing



    LHX9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LHX9 
    GenScript Custom Superior Antibodies Services for LHX9
    Novus Biologicals LHX9 Antibodies
    Search for Antibodies for LHX9 at Abcam  
    Uscn Antibodies for LHX9
    Search ThermoFisher Antibodies for LHX9

    Assay Products for LHX9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LHX9
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for LHX9

    Protein Domains /
    Families
    for LHX9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LHX9 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9NQ69

    ProtoNet protein and cluster: Q9NQ69

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LHX9_HUMAN, Q9NQ69
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    Function
    for LHX9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LHX9_HUMAN, Q9NQ69
    Function: Involved in gonadal development (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): LHX9
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX9
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX9:
    hsa-miR-647 hsa-miR-875-3p hsa-miR-362-3p hsa-miR-329 hsa-miR-802 hsa-miR-590-3p hsa-miR-3941 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmid: LHX9 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX9 (see all 7)
    OriGene shRNA RFP: LHX9
    OriGene siRNA: LHX9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX9

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LHX9

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX9 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX9 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): LHX9 (NM_001014434)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX9 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for LHX9
    Search LifeMap BioReagents cell lines for LHX9

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX9

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    LHX9 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for LHX9:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Lhx9tm1Lmgd for LHX9
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Lhx9):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  nervous system  no phenotypic analysis 
     reproductive system 

    LHX9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LHX9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LHX9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/28 Interacting proteins for LHX9 (Q9NQ693 ENSP000003563574) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
    LDB2O436793, ENSP000003067724I2D: score=2 STRING: ENSP00000306772
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    LDB1Q86U703, ENSP000003924664I2D: score=1 STRING: ENSP00000392466
    PYGO1Q9Y3Y43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008045motor neuron axon guidance ISS--
    GO:0008283cell proliferation IEA--
    GO:0008584male gonad development IEA--
    GO:0008585female gonad development IEA--
    GO:0035262gonad morphogenesis IEA--


    LHX9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LHX9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LHX9
    Search CenterWatch for drugs/clinical trials and news about LHX9 

    Transcripts
    for LHX9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LHX9 gene (2 alternative transcripts): 
    NM_001014434.1  NM_020204.2  

    Unigene Clusters for LHX9:

    LIM homeobox 9
    Hs.442578  [show with all ESTs], Hs.706475  [show with all ESTs]
    Unigene Representative Sequences: NM_020204, AK097614
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475727(uc009wzc.1) ENST00000367391(uc021pgw.1) ENST00000367390(uc001gui.1)
    ENST00000561173 ENST00000367388 ENST00000337020 ENST00000367387(uc001guk.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): LHX9
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX9
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX9:
    hsa-miR-647 hsa-miR-875-3p hsa-miR-362-3p hsa-miR-329 hsa-miR-802 hsa-miR-590-3p hsa-miR-3941 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmid: LHX9 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX9 (see all 7)
    OriGene shRNA RFP: LHX9
    OriGene siRNA: LHX9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX9
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX9 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX9 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): LHX9 (NM_001014434)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX9 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHX9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX9

    Additional cDNA sequence: AK097614.1 

    4 DOTS entries:

    DT.91952972  DT.99930905  DT.40307381  DT.97795069 

    24/25 AceView cDNA sequences (see all 25):

    CR625363 AL522820 AJ277915 AY273889 BM680709 BM930179 BM718821 AK097614 
    AA316988 NM_020204 BM683669 AI873441 BM719324 BM718831 AA708227 BX389397 
    BX452329 BM683255 AL556961 AJ296272 AA382798 AL522819 AJ277914 AA334261 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LHX9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12
    SP1:                                                  -                                             
    SP2:                    -     -     -                                                               
    SP3:                          -     -                 -                                             
    SP4:                                                                                      -         
    SP5:                                                                                                


    ECgene alternative splicing isoforms for LHX9

    Expression
    for LHX9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LHX9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACAGCCACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LHX9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadGonad Somatic CellsOvary, Testis
    TestisTestis CordPre-Sertoli CellsTestis
    Lateral Plate MesodermIntraembryonic CoelomCoelomic Epithelial CellsReproductive System
    LimbAutopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LimbStylopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    BrainHypothalamusBrain
    BrainThalamusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LHX9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LHX9

    SOURCE GeneReport for Unigene clusters: Hs.442578 Hs.706475
        SABiosciences Custom PCR Arrays for LHX9
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHX9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX9
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX9

    Orthologs
    for LHX9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LHX9 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LHX91 LIM homeobox 9 88.27(n)
    96.03(a)    		   396397  NM_205426.1  NP_990757.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LHX96
    LHX26
    		 --
    		 91(a)
    72(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343211.1(6713-41897)
    GL344062.1(67225-74152)
    African clawed frog
    (Xenopus laevis)    		 Amphibia lhx9-A2 LIM homeobox 9 77.85(n)    AJ311711.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BM316258.12   -- 80(n)    BM316258.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ap6
    		 apterous
    		 26(a)
    		 1 → many
    		 2R(1593707-1614335)
    worm
    (Caenorhabditis elegans)    		 Secernentea ttx-36
    		 abnormal ThermoTaXis family member (ttx-3)
    		 25(a)
    		 1 → many
    		 X(11764389-11769311)


    ENSEMBL Gene Tree for LHX9 (if available)
    TreeFam Gene Tree for LHX9 (if available) 

    Paralogs
    for LHX9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LHX9 gene
    LMO22  ISL12  LHX22  LMX1B2  LMO12  LHX52  LMO42  LHX62  
    LHX12  LMX1A2  LMO32  LHX42  LHX32  LHX82  ISL22  
    15 SIMAP similar genes for LHX9 using alignment to 3 protein entries:     LHX9_HUMAN (see all proteins):
    LHX2    LHx4    LHX4    POU6F1    LMO3    ISL2
    LMO4    LMO1    LMO2    LHX5    LHX1    LHX8
    ISL1    LHX6    LHX3

    LHX9 for paralogs           About GeneDecksing



    Genomic Variants
    for LHX9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/351 NCBI SNPs in LHX9 are shown (see all 351)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1426416401,2
    		--197879714(+) GTGGGC/TATCGC 1 -- us2k10--------
    rs782024141,2
    		C,F,--197879787(+) TCCTGG/ACTGCG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs125671491,2
    		C,F,A,H,--197880072(+) GTGGGT/GCAGGC 1 -- us2k18Minor allele frequency- G:0.44WA NA CSA EA 368
    rs1996521831,2
    		--197880166(+) CGTCC-/CC    
       CCACA    CCCCC     		1 -- us2k10--------
    rs2007877931,2
    		--197880169(+) CCCCC-/CACACCC 1 -- us2k10--------
    rs125669531,2
    		C,F,H--197880172(+) CCCACC/ACCCCC 1 -- us2k1 tfbs36Minor allele frequency- A:0.08NS CSA 966
    rs679740401,2
    		C,--197880172(-) GGGGG-/TGTGGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs2004749661,2
    		--197880175(+) CACCC-/TCCCCC 1 -- us2k10--------
    rs1482769031,2
    		--197880321(+) CCTCCC/TTACCG 1 -- us2k10--------
    rs1908673231,2
    		--197880400(+) ATGGGC/TAAATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LHX9 (197881618 - 197904608 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for LHX9
         1 CNV: 97607
         4 Indels: 42040 44485 39678 60920

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LHX9
    DNA2.0 Custom Variant and Variant Library Synthesis for LHX9

    Disorders / Diseases
    for LHX9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LHX9 for disorders           About GeneDecksing

    OMIM gene information: 606066    OMIM disorders: --

    3 diseases for LHX9:    About MalaCards
    frasier syndrome    malignant glioma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for LHX9:
    Frasier syndrome

    Export disorders for LHX9 gene to outside databases

    Publications
    for LHX9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LHX9 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with LHX9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Absence of mutations involving the LIM homeobox domain gene LHX9 in 46,XY gonadal agenesis and dysgenesis. (PubMed id 11397841)1, 2 Ottolenghi C.... McElreavey K. (2001)
    3. Transcriptional control of axonal guidance and sortin g in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1. (PubMed id 19545367)1, 9 Avraham O....Klar A. (2009)
    4. Aberrant methylation and reduced expression of LHX9 i n malignant gliomas of childhood. (PubMed id 19568415)1 Vladimirova V....Pietsch T. (2009)
    5. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain. (PubMed id 9880598)1 Retaux S....Besson M.J. (1999)
    10. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)

    External Searches for LHX9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LHX9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56956 HGNC: 14222 AceView: LHX9 Ensembl:ENSG00000143355 euGenes: HUgn56956
    ECgene: LHX9 H-InvDB: LHX9

    Other Databases showing LHX9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LHX9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LHX9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LHX9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LHX9 gene:
    Search GeneIP for patents involving LHX9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for LHX9 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for LHX9  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX9   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX9  
     OriGene Protein Over-expression Lysate for LHX9   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for LHX9   OriGene 3'-UTR Clone for LHX9  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX9   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX9  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LHX9   OriGene Custom Protein Services for LHX9  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LHX9
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LHX9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX9
     GenScript Custom Purified and Recombinant Proteins Services for LHX9 GenScript cDNA clones with any tag delivered in your preferred vector for LHX9
     GenScript Custom Assay Services for LHX9 GenScript Custom Superior Antibodies Services for LHX9
     GenScript Custom overexpressing Cell Line Services for LHX9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LHX9 promoter
     Search Chromatin IP Primers for LHX9
     RT2 qPCR Primer Assay in human, mouse, rat LHX9
     Search GNC Networks for LHX9
     SABiosciences Custom PCR Arrays for LHX9
     Search Tocris compounds for LHX9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LHX9 antibodies
     LHX9 proteins
     LHX9 lysates
     Search for Antibodies for LHX9 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for LHX9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     LHX9 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for LHX9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX9
     SwitchGear 3'UTR luciferase reporter plasmids for LHX9
     SwitchGear Promoter luciferase reporter plasmids for LHX9
     Search ThermoFisher Antibodies for LHX9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX9
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      LHX9 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4