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LHX9 Gene

protein-coding   GIFtS: 50
GCID: GC01P197881

LIM Homeobox 9

  See LHX9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Homeobox 91 2
LIM Homeobox Protein 92 3
LIM/Homeobox Protein Lhx92

External Ids:    HGNC: 142221   Entrez Gene: 569562   Ensembl: ENSG000001433557   OMIM: 6060665   UniProtKB: Q9NQ693   

Export aliases for LHX9 gene to outside databases

Previous GC identifers: GC01P195608 GC01P193340 GC01P194348 GC01P195169 GC01P194613 GC01P196148 GC01P169037


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LHX9 Gene:
This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The
encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein
interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated,
suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jul 2008)

GeneCards Summary for LHX9 Gene:
LHX9 (LIM homeobox 9) is a protein-coding gene. Diseases associated with LHX9 include frasier syndrome. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX9_HUMAN, Q9NQ69
Function: Involved in gonadal development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LHX9 gene promoter:
         STAT5B   Nkx2-5   E4BP4   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX9 promoter sequence
   Search Chromatin IP Primers for LHX9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHX9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.1   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q31.1

LHX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P197881:  view genomic region     (about GC identifiers)

Start:
197,881,037 bp from pter      End:
197,904,608 bp from pter
Size:
23,572 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LHX9_HUMAN, Q9NQ69 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx9  
Size: 397 amino acids; 43976 Da
Subunit: Interacts with LDB1 and LDB2 (By similarity)
1 PDB 3D structure from and Proteopedia for LHX9:
2DMQ (3D)    
Secondary accessions: Q5VUE2 Q5VUE3 Q5VUE6 Q86UH2 Q9BYU6 Q9NQ70
Alternative splicing: 4 isoforms:  Q9NQ69-1   Q9NQ69-2   Q9NQ69-3   Q9NQ69-4   

Explore the universe of human proteins at neXtProt for LHX9: NX_Q9NQ69

Explore proteomics data for LHX9 at MOPED


See LHX9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001014434.1  NP_064589.2  

ENSEMBL proteins: 
 ENSP00000356361   ENSP00000356360   ENSP00000453064   ENSP00000356358   ENSP00000337969  
 ENSP00000356357  

LHX9 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for LHX9

 
Search eBioscience for Proteins for LHX9 

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Abcam antibodies for LHX9 (Q9NQ69, Q86UH2)
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LSBio Antibodies in human, mouse, rat for LHX9

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LIM: Homeoboxes / LIM class

4 InterPro protein domains:
 IPR001781 Znf_LIM
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9NQ69

ProtoNet protein and cluster: Q9NQ69

1 Blocks protein domain: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LHX9_HUMAN, Q9NQ69
Similarity: Contains 1 homeobox DNA-binding domain
Similarity: Contains 2 LIM zinc-binding domains


Find genes that share domains with LHX9           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LHX9_HUMAN, Q9NQ69
Function: Involved in gonadal development (By similarity)

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0003714transcription corepressor activity ISS--
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with LHX9           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for LHX9:
 Decreased viability with pacli 

     6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lhx9):
 cellular  endocrine/exocrine gland  homeostasis/metabolism  nervous system  no phenotypic analysis 
 reproductive system 

Find genes that share phenotypes with LHX9           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Lhx9tm1Lmgd for LHX9

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LHX9
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LHX9

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHX9
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHX9

miRNA
Products:
    
miRTarBase miRNAs that target LHX9:
hsa-mir-335-5p (MIRT016753)

Block miRNA regulation of human, mouse, rat LHX9 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate LHX9:
hsa-miR-647 hsa-miR-875-3p hsa-miR-362-3p hsa-miR-329 hsa-miR-802 hsa-miR-590-3p hsa-miR-3941 hsa-miR-1299
SwitchGear 3'UTR luciferase reporter plasmidLHX9 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat LHX9

Gene Editing
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GenScript: all cDNA clones in your preferred vector (see all 2): LHX9 (NM_001014434)
Sino Biological Human cDNA Clone for LHX9
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX9
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX9

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX9


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LHX9_HUMAN, Q9NQ69: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with LHX9           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LHX9
Interactions:

    Search GeneGlobe Interaction Network for LHX9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for LHX9 (Q9NQ693 ENSP000003563574) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
InteractantInteraction Details
GeneCardExternal ID(s)
SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
LDB2O436793, ENSP000003067724I2D: score=2 STRING: ENSP00000306772
SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
LDB1Q86U703, ENSP000003924664I2D: score=1 STRING: ENSP00000392466
PYGO1Q9Y3Y43I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated ----
GO:0008045motor neuron axon guidance ISS--
GO:0008283cell proliferation IEA--
GO:0008584male gonad development IEA--
GO:0008585female gonad development IEA--

Find genes that share ontologies with LHX9           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LHX9



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for LHX9 gene (2 alternative transcripts): 
NM_001014434.1  NM_020204.2  

Unigene Cluster for LHX9:

LIM homeobox 9
Hs.442578  [show with all ESTs]
Unigene Representative Sequence: NM_020204
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000606127 ENST00000475727(uc009wzc.1) ENST00000367391(uc021pgw.1)
ENST00000367390(uc001gui.1) ENST00000561173 ENST00000367388 ENST00000337020
ENST00000367387(uc001guk.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat LHX9 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate LHX9:
hsa-miR-647 hsa-miR-875-3p hsa-miR-362-3p hsa-miR-329 hsa-miR-802 hsa-miR-590-3p hsa-miR-3941 hsa-miR-1299
SwitchGear 3'UTR luciferase reporter plasmidLHX9 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for LHX9
Predesigned siRNA for gene silencing in human, mouse, rat LHX9
Clone
Products:
     
OriGene clones in human, mouse for LHX9 (see all 11)
OriGene ORF clones in mouse, rat for LHX9
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): LHX9 (NM_001014434)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX9
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX9
Primer
Products:
    
OriGene qPCR primer pairs and template standards for LHX9
OriGene qSTAR qPCR primer pairs in human, mouse for LHX9
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX9
  QuantiTect SYBR Green Assays in human, mouse, rat LHX9
  QuantiFast Probe-based Assays in human, mouse, rat LHX9

Additional mRNA sequence: 

AJ277914.1 AJ277915.1 AJ296272.1 AY273889.2 BC131622.1 

4 DOTS entries:

DT.91952972  DT.40307381  DT.99930905  DT.97795069 

Selected AceView cDNA sequences (see all 25):

AA316988 AJ277915 BM680709 AK097614 BM930179 AL522820 CR625363 NM_020204 
AY273889 BM718821 AI873441 BX389397 AL556961 BM683255 BM683669 BM718831 
BM719324 AA708227 BX452329 AA382798 AJ296272 AL522819 AJ277914 AL556960 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for LHX9    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12
SP1:                                                  -                                             
SP2:                    -     -     -                                                               
SP3:                          -     -                 -                                             
SP4:                                                                                      -         
SP5:                                                                                                


ECgene alternative splicing isoforms for LHX9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LHX9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACAGCCACG
LHX9 Expression
About this image


LHX9 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 14) fully expand
 
 Ovary (Reproductive System)    fully expand to see all 3 entries
         Gonad Somatic Cells Primitive Gonad
 
 Gonad (Reproductive System)    fully expand to see all 2 entries
         Gonad Somatic Cells Primitive Gonad
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         Gonad Somatic Cells Primitive Gonad
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Metencephalon
 
 Limb (Muscoskeletal System)    fully expand to see all 3 entries
         Limb Muscle Progenitor Cells Forelimb Myotome
         Limb Bud
LHX9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LHX9 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.442578
    Custom PCR Arrays for LHX9
Primer
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QuantiFast Probe-based Assays in human, mouse, rat LHX9
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX9

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LHX9 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lhx91 , 5 LIM homeobox protein 91, 5 94.71(n)1
98.49(a)1
  1 (60.82 cM)5
168761  NM_001042577.11  NP_001036042.11 
 1388251865 
chicken
(Gallus gallus)
Aves LHX91 LIM homeobox 9 88.27(n)
96.03(a)
  396397  NM_205426.1  NP_990757.1 
lizard
(Anolis carolinensis)
Reptilia LHX96
LIM homeobox 9
91(a)
1 ↔ 1
GL343211.1(6713-41905)
African clawed frog
(Xenopus laevis)
Amphibia lhx9-A2 LIM homeobox 9 77.85(n)    AJ311711.1 
zebrafish
(Danio rerio)
Actinopterygii BM316258.12   -- 80(n)    BM316258.1 
fruit fly
(Drosophila melanogaster)
Insecta ap6
apterous
35(a)
1 → many
2R(1593707-1614335)
worm
(Caenorhabditis elegans)
Secernentea ttx-36
Protein TTX-3, isoform a
31(a)
1 → many
X(11764456-11769378) WBGene00006654


ENSEMBL Gene Tree for LHX9 (if available)
TreeFam Gene Tree for LHX9 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LHX9 gene
ISL12  LHX22  LMX1B2  LHX52  LHX62  LHX12  LMX1A2  LHX42  
LHX32  LHX82  ISL22  
14 SIMAP similar genes for LHX9 using alignment to 3 protein entries:     LHX9_HUMAN (see all proteins):
LHX2    LHx4    LHX4    POU6F1    LMO3    LMO4
LMO1    ISL2    LMO2    LHX8    LHX5    LHX1
ISL1    LHX6

Find genes that share paralogs with LHX9           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LHX9 (see all 430)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1426416401,2
--197879714(+) GTGGGC/TATCGC 1 -- us2k10--------
rs782024141,2
C,F--197879787(+) TCCTGG/ACTGCG 1 -- us2k11Minor allele frequency- A:0.03NA 120
rs125671491,2
C,F,A,H--197880072(+) GTGGGT/GCAGGC 1 -- us2k18Minor allele frequency- G:0.44WA NA CSA EA 368
rs2007877931,2
C--197880169(+) CCCCC-/CACACCC 1 -- us2k10--------
rs125669531,2
C,F,H--197880172(+) CCCACC/ACCCCC 1 -- us2k1 tfbs36Minor allele frequency- A:0.08NS CSA 966
rs679740401,2
C--197880172(-) GGGGG-/TGTGGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
rs2004749661,2
C--197880175(+) CACCC-/TCCCCC 1 -- us2k10--------
rs1482769031,2
C--197880321(+) CCTCCC/TTACCG 1 -- us2k10--------
rs1908673231,2
--197880400(+) ATGGGC/TAAATA 1 -- us2k10--------
rs1418183891,2
--197880541(+) ATCCCA/CTCTAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for LHX9 (197881037 - 197904608 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for LHX9:    About this table    
Variant IDTypeSubtypePubMed ID
dgv56e201CNV Deletion23290073
esv3513CNV Deletion18987735
esv2520814CNV Deletion19546169
esv2143475CNV Deletion18987734
esv2660965CNV Deletion23128226
esv1002483CNV Deletion20482838
esv2721117CNV Deletion23290073
esv2721095CNV Deletion23290073
nsv506971CNV Insertion20534489
esv8658CNV Loss19470904

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LHX9
DNA2.0 Custom Variant and Variant Library Synthesis for LHX9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606066    OMIM disorders: --

1 disease for LHX9:    
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frasier syndrome

1 disease from the University of Copenhagen DISEASES database for LHX9:
Frasier syndrome

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Export disorders for LHX9 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LHX9 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with LHX9)
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  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. Absence of mutations involving the LIM homeobox domain gene LHX9 in 46,XY gonadal agenesis and dysgenesis. (PubMed id 11397841)1, 2 Ottolenghi C.... McElreavey K. (J. Clin. Endocrinol. Metab. 2001)
  3. Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1. (PubMed id 19545367)1, 9 Avraham O....Klar A. (Neural Dev 2009)
  4. Aberrant methylation and reduced expression of LHX9 in malignant gliomas of childhood. (PubMed id 19568415)1 Vladimirova V....Pietsch T. (Neoplasia 2009)
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain. (PubMed id 9880598)1 RActaux S....Besson M.J. (J. Neurosci. 1999)
  10. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D.... White O. (Nature 1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56956 HGNC: 14222 AceView: LHX9 Ensembl:ENSG00000143355 euGenes: HUgn56956
ECgene: LHX9 H-InvDB: LHX9

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for LHX9 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LHX9 gene:
Search GeneIP for patents involving LHX9

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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