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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LHX8 Gene

protein-coding   GIFtS: 52
GCID: GC01P075594

LIM homeobox 8

 Explore 6 diseases affiliated with
LHX8 via our new
 Human Malady Compendium 
Biological research products
for LHX8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
LIM Homeobox 81 2
Lhx71
LHX72
LIM-Homeodomain Protein Lhx82
LIM/Homeobox Protein Lhx82
LIM Homeobox Protein 83

External Ids:    HGNC: 288381   Entrez Gene: 4317072   Ensembl: ENSG000001626247   OMIM: 6044255   UniProtKB: Q68G743   

Export aliases for LHX8 gene to outside databases

Previous GC identifers: GC01P075306 GC01P073728


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LHX8:
The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning
and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc
finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription
factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation.
This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative
splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74
Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LHX8 gene promoter:
         HNF-4alpha2   Nkx2-5   CUTL1   YY1   Egr-4   HNF-4alpha1   AREB6   PPAR-gamma1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX8 promoter sequence
   Search SABiosciences Chromatin IP Primers for LHX8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

LHX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P075594:  view genomic region     (about GC identifiers)

Start:
75,594,119 bp from pter      End:
75,627,218 bp from pter
Size:
33,100 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx8  
Size: 356 amino acids; 39301 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for LHX8: NX_Q68G74

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q68G74

  • LHX8 Protein expression data from MOPED and PaxDb:    About this image 
    LHX8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001001933.1  NP_001243043.1  

    ENSEMBL proteins: 
     ENSP00000294638   ENSP00000348597   ENSP00000453068  

    Human Recombinant Protein Products for LHX8: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LHX8

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    LHX8 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for LHX8


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LHX8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q68G74

    ProtoNet protein and cluster: Q68G74

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LHX8_HUMAN, Q68G74
    Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    LHX8 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lhx8):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size 
     mortality/aging  nervous system 

    LHX8 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Lhx8tm1Lmgd for LHX8
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LHX8 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: LHX8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX8
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX8 (see all 46):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidLHX8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX8 (see all 7)
    OriGene shRNA RFP: LHX8
    OriGene siRNA: LHX8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX8
    Sirion Biotech Custom design and validation of potent shRNA sequences against LHX8 

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LHX8
    Sirion Biotech Customized adenovirus for overexpression of LHX8 
    Sirion Biotech Customized adenovirus for potent knockdown of LHX8

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX8 (see all 3)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LHX8
    LifeMap BioReagents: cell lines associated with LHX8: PureStem 4D20.8, NCr-fac Progenitor,
    PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    Sirion Biotech Customized stable knockdown cell line services for LHX8 
    Sirion Biotech Customized inducible knockdown cell line services for LHX8
    Sirion Biotech Customized stable overexpressing cell line services for LHX8
    Sirion Biotech Customized inducible overexpressing cell line services for LHX8

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LHX8

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007611learning or memory IEA--
    GO:0008585female gonad development IEA--
    GO:0021879forebrain neuron differentiation ----
    GO:0021884forebrain neuron development IEA--

    LHX8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LHX8
    Search CenterWatch for drugs/clinical trials and news about LHX8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LHX8 gene (2 alternative transcripts): 
    NM_001001933.1  NM_001256114.1  

    Unigene Cluster for LHX8:

    LIM homeobox 8
    Hs.403934  [show with all ESTs]
    Unigene Representative Sequence: BC040321
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294638(uc021oou.1 uc001dgo.3) ENST00000356261(uc001dgq.3)
    ENST00000559413

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: LHX8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX8
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX8 (see all 46):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidLHX8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX8 (see all 7)
    OriGene shRNA RFP: LHX8
    OriGene siRNA: LHX8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX8
    Sirion Biotech Custom design and validation of potent shRNA sequences against LHX8 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHX8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX8

    Additional cDNA sequence: 

    BC036423.1 BC040321.1 

    3 DOTS entries:

    DT.95088275  DT.92020528  DT.95222210 

    9 AceView cDNA sequences:

    NM_001001933 BC040321 BF978460 AK094667 BG772403 BC036423 BF572867 BG709099 
    AA331573 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LHX8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAACACATT
    LHX8 Expression
    About this image

    LHX8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeCervical Brown Adipose DepotCervical Brown Adipocyte CellsAdipose
    AdiposeCervical Brown Adipose DepotCervical Committed Brown PreadipocytesAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Brown Adipocyte CellsAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Committed Brown PreadipocytesAdipose
    AdiposeSacral Brown Adipose DepotSacral Brown Adipocyte CellsAdipose
    AdiposeSacral Brown Adipose DepotSacral Committed Brown PreadipocytesAdipose
    AdiposeThoracic Brown Adipose DepotThoracic Brown Adipocyte CellsAdipose
    AdiposeThoracic Brown Adipose DepotThoracic Committed Brown PreadipocytesAdipose
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Head MesenchymePrechordal MesenchymeMesencephalic Neural Crest CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    Ovarian tissue-dissociated cells (human) (Primary Cell)Ovary, Reproductive System
    Oocytes (Oocyte formation by ...)
    Human oogonial stem cells (Oocyte formation by ...)
    Human oogonial stem cells (Oocyte formation by ...)
    Oocytes (Oocyte formation by ...)

    See LHX8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LHX8

    SOURCE GeneReport for Unigene cluster: Hs.403934
        SABiosciences Custom PCR Arrays for LHX8
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LHX8 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LHX81 LIM homeobox 8 87.24(n)
    96.19(a)
      424721  NM_001040466.1  NP_001035556.1 
    lizard
    (Anolis carolinensis)
    Reptilia LHX86
    --
    84(a)
    1 ↔ 1
    GL343194.1(2994876-3018755)
    zebrafish
    (Danio rerio)
    Actinopterygii lhx8a1 LIM homeobox 8a 68.42(n)
    77.5(a)
      378959  NM_001003980.1  NP_001003980.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Awh6
    Arrowhead
    37(a)
    1 → many
    3L(3846206-3861692)
    worm
    (Caenorhabditis elegans)
    Secernentea lim-46
    LIM domain family member (lim-4)
    29(a)
    1 → many
    X(3869734-3873276)


    ENSEMBL Gene Tree for LHX8 (if available)
    TreeFam Gene Tree for LHX8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LHX8 gene
    LMO22  ISL12  LHX22  LHX92  LMX1B2  LMO12  LHX52  LMO42  
    LHX62  LHX12  LMX1A2  LMO32  LHX42  LHX32  ISL22  
    18/30 SIMAP similar genes for LHX8 using alignment to 5 protein entries:     LHX8_HUMAN (see all proteins) (see all similar genes):
    Lhx8    LHX6    LHX4    LIMD1    LHx4    LHX3
    FBLIM1    LHX1    TES    LMO4    POU6F1    ISL2
    ABLIM2    WTIP    LMO1    ZYX    LMX1B    LPP

    LHX8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    490/521 NCBI SNPs in LHX8 are shown (see all 521    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs170962891,2
    C,F,H--75592165(+) CTGCCG/ACCTAT 1 -- us2k117Minor allele frequency- A:0.36NA NS EA WA CSA 934
    rs104935521,2
    C,F,A,H--75592228(+) AAGAGC/ATTAGC 1 -- us2k117Minor allele frequency- A:0.40NS NA EA WA 1026
    rs1421244521,2
    --75592391(+) TTTGCC/TGTGTT 1 -- us2k10--------
    rs359544321,2
    F--75592726(+) AGACTC/TCATCT 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs8138341,2
    C,H--75592800(-) GCCTAG/TAAAGG 1 -- us2k1 trp36Minor allele frequency- T:0.00NS EA NA 424
    rs1901226771,2
    --75592896(+) TGAAGC/GAAGCC 1 -- us2k10--------
    rs8142701,2
    H--75592919(-) GGCCAG/CACATT 1 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs758409631,2
    F--75592932(+) CACACA/GCAGCA 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs8084701,2
    H--75593043(-) ATACAG/CGAGGC 1 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs1816610431,2
    --75593138(+) TCGCAC/GGAGGG 1 -- us2k10--------
    rs752022381,2
    F--75593148(+) GAAGAA/GCTCAA 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs127512071,2
    C,F,H--75593345(+) AGTGGG/CGCGTT 1 -- us2k111Minor allele frequency- C:0.10NA EA NS CSA WA 682
    rs746779771,2
    C,F--75593346(+) NNNNGG/ACGTTT 1 -- us2k11Minor allele frequency- A:0.09NA 120
    rs1469410051,2
    --75593447(+) TGAGCA/GAGAAG 1 -- us2k10--------
    rs1379039621,2
    --75593526(+) TGCCAA/GCATAT 1 -- us2k10--------
    rs1408982861,2
    --75593725(+) CAGTAA/TATGAG 1 -- us2k10--------
    rs176226061,2
    C,F--75593836(+) GAAGTG/AANNNN 1 -- us2k14Minor allele frequency- A:0.03NA 262
    rs1501625491,2
    --75593856(+) GACCTC/TAGTCT 1 -- us2k10--------
    rs111625671,2
    C,F,A,H--75593875(+) ATCGAA/GTCACC 1 -- us2k131Minor allele frequency- N:0.00EA NA NS WA CSA 2988
    rs1855530551,2
    --75593962(+) AGAACG/TATTTT 1 -- us2k10--------
    rs1899181541,2
    --75593974(+) CCGCCG/TATTTA 1 -- us2k10--------
    rs762331411,2
    F--75594097(+) CCCCCC/TAGCTG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs412892281,2
    F--75594154(+) GTGCTG/CGAGTG 1 -- ut511Minor allele frequency- C:0.07WA 118
    rs1822260671,2
    --75594189(+) TACTGA/TAAGTG 1 -- ut510--------
    rs1385973161,2
    --75594321(+) TTAAAA/GTAGGG 1 -- int10--------
    rs124035121,2
    C,H--75594324(+) AAGTAG/AGGTTG 1 -- int16Minor allele frequency- A:0.00NS EA NA 424
    rs125634451,2
    C,F,H--75594348(+) CAGTGG/CGGGCA 1 -- int15Minor allele frequency- C:0.41WA NA EA 366
    rs1492856631,2
    --75594445(+) ATTTTA/TAAATG 1 -- int10--------
    rs1852229891,2
    --75594517(+) TCCTTC/GGGCCT 1 -- int10--------
    rs1910061091,2
    --75594569(+) TCTGGA/CGCCTC 1 -- int10--------
    rs1156891981,2
    --75594635(+) CAACTC/TGCTGA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1463360431,2
    --75594720(+) GTGAAA/GGAGGA 1 -- int10--------
    rs1383630031,2
    --75594844(+) TGAGAA/CAGCTC 1 -- int10--------
    rs1141217341,2
    F--75594994(+) GAAGGG/CAGAGG 1 -- int11Minor allele frequency- C:0.02WA 118
    rs111625711,2
    C,F,H--75595151(+) CTTTAT/CGAGTT 1 -- int126Minor allele frequency- C:0.07NA NS EA WA CSA 2493
    rs1839972911,2
    --75595168(+) GAGGTA/GGAAGT 1 -- int10--------
    rs1428500931,2
    --75595210(+) GTGGGC/TGGTCG 1 -- int10--------
    rs1460703401,2
    --75595339(+) ACCTAC/TCCCCA 1 -- int10--------
    rs759552481,2
    --75595425(+) TCAGAC/TATCCC 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1151670491,2
    --75595481(+) AAGGGC/TCTCGG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1400180931,2
    --75595521(+) CAGGCA/TATATC 1 -- int10--------
    rs672978751,2
    C--75595589(+) TGGAT-/TCTC  
            
    TCTCT
    1 -- int11Minor allele frequency- TCTC:0.50CSA 2
    rs1412661941,2
    C--75595589(+) TGGAT-/TCTCTCT 1 -- int10--------
    rs345269691,2
    C--75595590(+) TCTCT-/CTCT  
            
    GGCCA
    1 -- int11Minor allele frequency- CTCT:0.00NA 2
    rs2012066181,2
    --75595603(+) CTCTC-/TCTG  
            
    GCCAC
    1 -- int10--------
    rs1890031221,2
    --75595837(+) TTAGCA/CGGGAA 1 -- int10--------
    rs790498281,2
    F--75595844(+) GGAAGC/GTTTCC 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1424668481,2
    --75595929(+) CCCCTA/CTTTCT 1 -- ut510--------
    rs1929399971,2
    --75595958(+) AGCTTA/CCTGGC 1 -- ut510--------
    rs412892301,2
    --75595976(+) GAACCG/TGCTGG 1 -- ut510--------
    rs412892321,2
    --75596330(+) AAGGTA/GTAAAA 1 -- ut510--------
    rs2008678861,2
    --75596370(+) GAGCCC/GGTATA 1 -- ut510--------
    rs2001159721,2
    --75596381(+) CAGCTC/TTGCCA 1 -- ut510--------
    rs1916462691,2
    C--75596384(+) CTCTGC/TCATCT 1 -- ut510--------
    rs412892341,2
    C,F--75596388(+) GCCATC/GTCTGA 1 -- ut513Minor allele frequency- G:0.03NA EU 1445
    rs2021031181,2
    C--75596410(+) GATTCC/TGAGCA 2 P L mis10--------
    rs795731681,2
    F--75596548(+) GACATC/TCACAG 1 -- int11Minor allele frequency- T:0.08WA 118
    rs1167106101,2
    --75596798(+) CGCCCG/AGGAGT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs115825751,2
    H--75596874(+) CAGGTC/TTGACC 1 -- int10--------
    rs1146729021,2
    F--75596960(+) CCTGAG/ACACCG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1841436421,2
    --75597008(+) ACTCAA/CCCCGA 1 -- int10--------
    rs1884683881,2
    --75597031(+) CAAAGG/TGTTCA 1 -- int10--------
    rs1926480531,2
    --75597039(+) TCAATA/TGTCAA 1 -- int10--------
    rs1856114281,2
    --75597183(+) CGCCTA/GCAGTG 1 -- int10--------
    rs1508977771,2
    C--75597208(+) AAATAC/TCAGTT 1 -- int10--------
    rs121291581,2
    C,F--75597376(+) CAAGGC/GCTGGC 1 -- int15Minor allele frequency- G:0.35NA 128
    rs1905171711,2
    --75597398(+) TAGACC/TCCTTC 1 -- int10--------
    rs1817310511,2
    --75597436(+) ACACTC/TAAGGC 1 -- int10--------
    rs121291931,2
    C,F--75597485(+) CACTCC/TGAAGT 1 -- int17Minor allele frequency- T:0.20NA CSA WA 248
    rs758820061,2
    F--75597661(+) GATGTT/GTTTTT 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1857033771,2
    --75597972(+) CATTCA/CCCTCT 1 -- int10--------
    rs1393594571,2
    --75598024(+) GGACAC/TAGAAA 1 -- int10--------
    rs125652721,2
    C,F,H--75598070(+) GGGTGC/AGCGCA 1 -- int15Minor allele frequency- A:0.39WA NA EA 366
    rs1500248211,2
    --75598111(+) AAGGCG/TCCTGG 1 -- int10--------
    rs2019420241,2
    --75598473(+) ACACA-/CTGTAAT 1 -- int10--------
    rs121326091,2
    C--75598474(+) CACACT/AGTAAT 1 -- int14Minor allele frequency- A:0.19NA CSA WA 242
    rs1477163061,2
    --75598521(+) TTTCAA/GCGAAA 1 -- int10--------
    rs1412772991,2
    --75598823(+) CCAGAG/TAGGAC 2 -- int1 us2k10--------
    rs15265051,2
    C,F,A,H--75598900(-) TCAGAG/ACATTT 2 -- int1 us2k122Minor allele frequency- A:0.35NS EA NA WA 2694
    rs120795041,2
    --75598977(+) CCCAGA/GCTCTT 2 -- int1 us2k10--------
    rs1405074021,2
    C--75599011(+) AAAGG-/CTAT  
            
    CTATC
    2 -- int1 us2k10--------
    rs1888909311,2
    --75599042(+) GCTGAA/CCGAGC 2 -- us2k1 int10--------
    rs1475710421,2
    --75599148(+) TATTTA/CCATCT 2 -- us2k1 int10--------
    rs2014892111,2
    --75599178(+) GATTC-/TGTTAAA 2 -- int1 us2k10--------
    rs1490238061,2
    --75599319(+) TTATAC/TCACAA 2 -- int1 us2k10--------
    rs1813423581,2
    --75599483(+) TACTCA/TTTAGC 2 -- us2k1 int10--------
    rs1431874201,2
    --75599495(+) ACATAC/TTTTTG 2 -- us2k1 int10--------
    rs120777961,2
    F--75599558(+) TTGCTC/AAGATG 2 -- us2k1 int11Minor allele frequency- A:0.03WA 118
    rs1154379261,2
    F--75599610(+) CGCGAA/GCTGCT 2 -- us2k1 int11Minor allele frequency- G:0.03WA 118
    rs15265041,2
    C,F,A,H--75599640(-) GCTCCT/AGGCAG 2 -- us2k1 int110Minor allele frequency- A:0.42NA EA WA 726
    rs1482626321,2
    --75599653(+) TGGCAC/TTCCTC 2 -- us2k1 int10--------
    rs1403882541,2
    --75599761(+) AACCTG/TAATCT 2 -- us2k1 int10--------
    rs1853723821,2
    --75599989(+) ACACGC/GCCCCT 2 -- us2k1 int10--------
    rs1154731771,2
    --75599997(+) CCTTCC/TTTTAT 2 -- us2k1 int10--------
    rs1455047951,2
    --75600082(+) CTCACC/TTCACT 2 -- int1 us2k10--------
    rs1909242901,2
    --75600209(+) CTTTTA/GTTAGT 2 -- int1 us2k10--------
    rs57752731,2
    C--75600507(+) TTTTTTT/-TTTAT 2 -- us2k1 int1 trp31Minor allele frequency- -:0.00NA 2
    rs1826822421,2
    --75600709(+) GACTGA/GGCGGC 2 -- int10--------
    rs1126759301,2
    --75600739(+) CCTGGA/CTCGTT 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1428919221,2
    --75600742(+) GGCTCA/GTTTCG 2 -- int10--------
    rs1387344521,2
    --75600941(+) TCACTC/TGGGAG 2 -- int10--------
    rs1493375531,2
    --75600958(+) CCTGTA/GGGTAT 2 -- int10--------
    rs7298331,2
    C,F,A,H--75601145(-) CGCGGG/AACCCA 2 -- int18Minor allele frequency- A:0.12MN NS EA WA NA 954
    rs1873125251,2
    --75601151(+) CCGCGC/TAGGGA 2 -- int10--------
    rs559830221,2
    C--75601193(+) CGGTCC/TGGGAG 2 -- int12Minor allele frequency- T:0.10NA 122
    rs1448436991,2
    --75601253(+) GAGGCA/GAACAG 2 -- int10--------
    rs1485955391,2
    --75601410(+) AGTAAC/TGCGCG 2 -- int10--------
    rs1921091961,2
    --75601485(+) GCTGGA/TTATTT 2 -- int10--------
    rs1420060631,2
    --75601676(+) ATTCAA/TATTGT 2 -- int10--------
    rs1473064661,2
    --75601685(+) GTCATC/TGGAAC 2 -- int10--------
    rs1830692031,2
    --75601798(+) TATATA/GTGTGT 2 -- int10--------
    rs1876575811,2
    --75601817(+) TTTAAA/TTGAGG 2 -- int10--------
    rs1440820851,2
    --75602016(+) GGGAA-/CCCGAC 2 -- int10--------
    rs1409038121,2
    --75602214(+) CGCGCC/TGAGGC 2 -- int10--------
    rs1921502701,2
    C--75602272(+) TCTCCC/TCCTCC 2 -- int10--------
    rs1165900341,2
    C,F--75602300(+) GGCTCA/CTGTCA 4 M L mis12Minor allele frequency- C:0.01WA NA 2690
    rs715006731,2
    C--75602384(+) GTGCGG/TAGGGG 2 -- int16Minor allele frequency- T:0.19NA CSA WA 245
    rs2009770091,2
    --75602391(+) GGGGCA/TCGCGT 2 -- int10--------
    rs115810021,2
    C,H--75602533(+) GCTTAG/TCTGGC 2 -- int10--------
    rs1416411791,2
    C,F--75602801(+) GGGAGC/TGGGGG 4 A V mis11Minor allele frequency- T:0.01NA 3650
    rs1494226951,2
    F--75602922(+) CTGGAG/AATCGT 4 /E syn11Minor allele frequency- A:0.00NA 4436
    rs15265031,2
    C--75603055(-) AACCTC/TCACCC 2 -- int114Minor allele frequency- T:0.00MN NA WA CSA EA 561
    rs1150988391,2
    F--75603080(+) AAAATC/TAGCCC 2 -- int11Minor allele frequency- T:0.05WA 118
    rs1141454351,2
    F--75603086(+) AGCCCA/CGTTTA 2 -- int11Minor allele frequency- C:0.11WA 118
    rs66954231,2
    C,F,A,H--75603101(+) AACTCA/GTGCGG 2 -- int111Minor allele frequency- G:0.17NS EA NA CSA 546
    rs782009591,2
    --75603141(+) CTTCTA/GTGTCG 2 -- int11Minor allele frequency- G:0.01WA 118
    rs1881235391,2
    --75603192(+) CGCCGC/GATGTG 2 -- int10--------
    rs1924011831,2
    --75603195(+) CGGATG/TTGTGT 2 -- int10--------
    rs1451462221,2
    --75603202(+) GTGTGA/GATGCG 2 -- int10--------
    rs66812581,2
    C,F,A--75603207(+) NNNNCG/TCTGGA 2 -- int17Minor allele frequency- T:0.21NA CSA WA 248
    rs1494463281,2
    --75603222(+) GCCAC-/TG    
       GCTTG
    TAGTG
    2 -- int10--------
    rs726796841,2
    --75603232(+) TGTAGG/TGGAAG 2 -- int10--------
    rs1161848861,2
    C,F--75603424(+) GATTCC/TCTTTT 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1842596791,2
    --75603440(+) GTCTCC/TTTTGG 2 -- int10--------
    rs1904221331,2
    --75603572(+) TAAAAA/GCCATT 2 -- int10--------
    rs120366671,2
    C--75603630(+) AATGCT/CGTTGT 2 -- int14Minor allele frequency- C:0.39WA NA EA 360
    rs75355341,2
    C,F--75603634(+) CTGTTG/TTTACA 2 -- int17Minor allele frequency- T:0.37WA NA CSA EA 366
    rs1926533031,2
    --75603687(+) TTAGAC/TACACA 2 -- int10--------
    rs1846851001,2
    --75603807(+) GCCACA/TGTTAT 2 -- int10--------
    rs15265021,2
    C,F--75604014(-) AACACG/AANNNN 2 -- int16Minor allele frequency- A:0.20NA WA 246
    rs1475810891,2
    --75604056(+) ACAAAC/GCTTCT 2 -- int10--------
    rs354530941,2
    C,F--75604121(+) AAGAAG/ATTTTG 2 -- int16Minor allele frequency- A:0.19NA CSA WA 246
    rs1394681371,2
    --75604255(+) ACTGAG/TCATTT 2 -- int10--------
    rs1496774971,2
    --75604520(+) TAAGTC/GAGTTA 2 -- int10--------
    rs1890402081,2
    --75604529(+) TACATA/GAAGCT 2 -- int10--------
    rs1814777991,2
    --75604579(+) TCCATA/GTACAG 2 -- int10--------
    rs1158988501,2
    C,F--75604743(+) AAAAAA/GAAGTT 2 -- int11Minor allele frequency- G:0.08WA 118
    rs750333151,2
    --75604883(+) CAGTGC/TTCTGT 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1454594801,2
    --75604894(+) CCTTCA/GGGTAG 2 -- int10--------
    rs1489105421,2
    --75604993(+) CCTTAC/GTTTAC 2 -- int10--------
    rs8115981,2
    H--75605027(+) AAACAG/CACATT 2 -- int14Minor allele frequency- C:0.00NS EA 414
    rs1840552041,2
    --75605049(+) GTGAAC/GTTTGA 2 -- int10--------
    rs121290291,2
    C--75605228(+) ATACTG/AGTTGG 2 -- int15Minor allele frequency- A:0.36NA 128
    rs1455458151,2
    --75605331(+) GATTTA/CTTTCT 2 -- int10--------
    rs1464909161,2
    --75605492(+) AGCTTC/TGAAGT 2 -- int10--------
    rs1897401301,2
    --75605627(+) ATTGGA/TTCCAT 2 -- int10--------
    rs1458162871,2
    C--75605722(+) TTAAC-/AAGAGCA 2 -- int10--------
    rs1409820411,2
    --75605810(+) CGCTTA/GTAATA 2 -- int10--------
    rs1121230441,2
    --75606162(+) TAACTG/ATCTTA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs15265011,2
    C,H--75606177(-) GAAAAC/TGCAGG 2 -- int114Minor allele frequency- T:0.00NA WA CSA EA 379
    rs1483137401,2
    --75606232(+) TTTAGC/TCAAAA 2 -- int10--------
    rs1808817081,2
    --75606326(+) AACCTG/TTATGT 2 -- int10--------
    rs729892611,2
    C--75606349(+) TAACCA/GAACTA 2 -- int12Minor allele frequency- G:0.10WA 120
    rs1859320071,2
    --75606372(+) ATAAAC/GATTCC 2 -- int10--------
    rs1414618711,2
    --75606405(+) AACCTC/GAATTC 2 -- int10--------
    rs1907459591,2
    --75606490(+) GATAAC/TATATC 2 -- int10--------
    rs1504145791,2
    --75606536(+) AAATGA/TCATCT 2 -- int10--------
    rs1381301761,2
    --75606608(+) CAATAC/TACAAA 2 -- int10--------
    rs1441312721,2
    --75606989(+) ATTCAA/GTAGAC 2 -- int10--------
    rs1432870211,2
    C--75607055(+) CAAAC-/AGGGAAT 2 -- int10--------
    rs1820820631,2
    --75607116(+) ACAACA/GCCCCT 2 -- int10--------
    rs1381252711,2
    --75607134(+) GGGAA-/TGGTTA 2 -- int10--------
    rs1863716631,2
    --75607172(+) AAAATC/TAAGAT 2 -- int10--------
    rs1473166901,2
    --75607222(+) ACTTAC/TAAACC 2 -- int10--------
    rs1907767441,2
    --75607327(+) AAACTA/GTTTCT 2 -- int10--------
    rs1409431571,2
    --75607389(+) TGTGAC/TCTCTG 2 -- int10--------
    rs1431699551,2
    --75607391(+) TGATCC/TCTGTG 2 -- int10--------
    rs1447813721,2
    --75607502(+) TTTTCC/TTTATT 2 -- int10--------
    rs1829312391,2
    --75607536(+) CATTGG/TAAAAC 2 -- int10--------
    rs1879872971,2
    --75607541(+) TAAAAC/TGGGGA 2 -- int10--------
    rs15265141,2
    C,F,O,H--75607651(+) GGTAAT/CTTAAA 2 -- int116Minor allele frequency- C:0.04NA NS EA WA CSA 923
    rs1912614471,2
    --75607659(+) AAAGTA/GATTTA 2 -- int10--------
    rs1829544071,2
    --75607663(+) TAATTG/TATGAG 2 -- int10--------
    rs1486508141,2
    --75607893(+) CCTTGC/TTTCAT 2 -- int10--------
    rs1421033231,2
    --75608170(+) AATTTA/TGAAAA 2 -- int10--------
    rs1161743821,2
    --75608207(+) TACAAT/CAGCTT 2 -- int11Minor allele frequency- C:0.01NA 120
    rs359362541,2
    C--75608329(+) CCTAA-/AAACTATA 2 -- int11Minor allele frequency- AAA:0.00NA 2
    rs722532441,2
    C--75608329(+) ATCCT-/AAAAACTA 2 -- int11Minor allele frequency- AAA:0.00CSA 2
    rs1511528631,2
    --75608432(+) TTTTGC/TACTTT 2 -- int10--------
    rs1880421041,2
    --75608483(+) CTTTAA/GGTAAA 2 -- int10--------
    rs1441630711,2
    --75608558(+) TCAATC/TTTCTT 2 -- int10--------
    rs1911828821,2
    C--75608782(+) ACCTTC/TCACAC 2 -- int10--------
    rs120843091,2
    C,F,H--75608854(+) ACTGAC/TTGGGT 4 D syn1 ese310Minor allele frequency- T:0.01NS EA NA WA 5306
    rs120414651,2
    C,F,H--75609049(+) TTTTGA/CGTCTT 2 -- int123Minor allele frequency- C:0.35NA NS EA WA 2888
    rs1848156721,2
    --75609297(+) TTGCTA/GGGCCT 2 -- int10--------
    rs1465031111,2
    --75609316(+) TACTTC/TTAACT 2 -- int10--------
    rs118077821,2
    C,F,H--75609329(+) TTGAAC/ATTTTC 2 -- int15Minor allele frequency- A:0.02NS EA NA 420
    rs1876209031,2
    --75609338(+) TCACTA/GAATAT 2 -- int10--------
    rs412892361,2
    F--75609415(+) TTGCCG/ATCTAG 2 -- int11Minor allele frequency- A:0.07WA 118
    rs2003500331,2
    --75609521(+) TTTTTA/TAAATG 2 -- int10--------
    rs1478679301,2
    C,F--75609555(+) GGTGCC/TCTCCT 4 A syn12Minor allele frequency- T:0.00NA EU 5873
    rs1921947601,2
    --75609847(+) ATTCAA/GGTTTT 2 -- int10--------
    rs120741231,2
    C,F,H--75609926(+) GCATCG/ATTCTG 2 -- int114Minor allele frequency- A:0.02NS EA NA 1680
    rs1455622951,2
    --75610091(+) TACAGC/TTTTTG 2 -- int10--------
    rs1155472011,2
    F--75610194(+) AGGGAG/ATACTT 2 -- int11Minor allele frequency- A:0.07WA 118
    rs1395564981,2
    --75610247(+) AGGGA-/TTTTTT 2 -- int10--------
    rs57752761,2
    C--75610248(+) TTTTTT/-AGCTT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs726796861,2
    --75610344(+) CCTATA/GTAATG 2 -- int10--------
    rs104935531,2
    C,F,H--75610411(+) GCTGAG/AGTATT 2 -- int117Minor allele frequency- A:0.42NS NA EA WA 900
    rs1165882921,2
    F--75610414(+) GAGGTA/GTTTGT 2 -- int11Minor allele frequency- G:0.09WA 118
    rs1851071741,2
    --75610415(+) AGGTAA/TTTGTT 2 -- int10--------
    rs1896287631,2
    --75610424(+) TTTCAC/TGTTAA 2 -- int10--------
    rs18523481,2
    C,F,A,H--75610451(+) NNNNAC/TGCCTA 2 -- int116Minor allele frequency- T:0.15NS EA NA CSA WA 980
    rs753054051,2
    C--75610500(+) GCTCAA/GACTTT 2 -- int10--------
    rs18523491,2
    C,F,A,H--75610562(+) NNNNCG/ATTTAG 2 -- int194Minor allele frequency- A:0.06NS EA PA EU CA WA NA 4914
    rs1815707751,2
    --75610596(+) AAGATA/GGATAC 2 -- int10--------
    rs127323291,2
    C,F,H--75610643(+) TTTAGA/GAAAGA 2 -- int1 trp318Minor allele frequency- G:0.13NS EA NA CSA WA 2140
    rs285445431,2
    C,F--75610729(+) CAGAAG/AAATTT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1489618401,2
    --75610771(+) TTTAGA/GCATAA 2 -- int10--------
    rs1437010581,2
    --75610780(+) AAATTC/TGATTT 2 -- int10--------
    rs1113447371,2
    C--75610913(+) CAATGC/ACCTGT 2 -- int12Minor allele frequency- A:0.04NA 122
    rs1480906491,2
    --75610987(+) AAATAA/GAATCT 2 -- int10--------
    rs1847501461,2
    --75611165(+) TACAAA/GTACTA 2 -- int10--------
    rs1895745791,2
    --75611332(+) GATTTG/TGAACC 2 -- int10--------
    rs1423277511,2
    --75611465(+) AATCTC/TGTAGA 2 -- int10--------
    rs39257491,2
    C,F,H--75611510(+) GCCTTG/ACATTA 2 -- int127Minor allele frequency- A:0.09NA NS EA WA CSA 2477
    rs1469050541,2
    --75611614(+) TACTGA/GTGAAA 2 -- int10--------
    rs1158412481,2
    F--75611649(+) ATATTC/GTCATT 2 -- int11Minor allele frequency- G:0.07WA 118
    rs1159913211,2
    --75611722(+) GTCCTA/GAAGTG 2 -- int11Minor allele frequency- G:0.01NA 120
    rs1393931031,2
    --75611738(+) TTATAA/GTTTAG 2 -- int10--------
    rs1808101631,2
    --75611832(+) CTCCTA/GCATTT 2 -- int10--------
    rs121336141,2
    C,F,A,H--75611859(+) TTCAAC/GTAGAG 2 -- int121Minor allele frequency- G:0.17NA NS EA WA 2262
    rs1865030351,2
    --75611939(+) CTGCTA/TTGGAC 2 -- int10--------
    rs1908413621,2
    --75612006(+) GAGATC/TTATGG 2 -- int10--------
    rs1433128731,2
    --75612048(+) TATTGA/GCAAAT 2 -- int10--------
    rs1816270091,2
    --75612060(+) TATTTA/CAAATA 2 -- int10--------
    rs1508858611,2
    --75612068(+) ATACCA/GTCCCA 2 -- int10--------
    rs1871313971,2
    --75612168(+) AACACA/GCCAAA 2 -- int10--------
    rs1382635851,2
    --75612238(+) TTCTGG/TTAGAT 2 -- int10--------
    rs1492760011,2
    --75612334(+) CAGCAG/TCATTA 2 -- int10--------
    rs15265111,2
    C,F,H--75612367(+) AAGTAG/CAAATT 2 -- int110Minor allele frequency- C:0.15NS EA NA WA 662
    rs22045601,2
    C,F,O,A,H--75612536(+) ATACAA/GTTTGA 2 -- int126Minor allele frequency- G:0.11NS EA NA 2680
    rs1167401001,2
    F--75612703(+) TTGGGG/TTTATT 2 -- int11Minor allele frequency- T:0.08WA 118
    rs1143755861,2
    --75612739(+) ACTCTA/GTTTTC 2 -- int11Minor allele frequency- G:0.01WA 118
    rs1444820761,2
    --75612790(+) AAGAAC/TAAAGT 2 -- int10--------
    rs1391008591,2
    --75612852(+) AAAATC/TCATGT 2 -- int10--------
    rs1439655741,2
    --75612859(+) ATGTTC/GTGTTT 2 -- int10--------
    rs1459361971,2
    --75612985(+) ATTGGC/TCTTTT 2 -- int10--------
    rs1399950361,2
    --75613019(+) CCTTAC/TATTGC 2 -- int10--------
    rs1915557701,2
    --75613036(+) TTACTC/TTGTCA 2 -- int10--------
    rs1833700661,2
    --75613093(+) GGATAC/TGAAAA 2 -- int10--------
    rs15265121,2
    C,F,H--75613097(+) ACGAAG/AAATAA 2 -- int134Minor allele frequency- A:0.06EA NA NS WA CSA 2996
    rs15265131,2
    C,F,O,A,H--75613259(+) AGAGTA/GAAGTC 2 -- int130Minor allele frequency- G:0.42MN EA NA NS WA CSA 2754
    rs1434579981,2
    --75613262(+) GTGAAC/GTCCAG 2 -- int10--------
    rs1512041221,2
    --75613332(+) ATCACA/TTTGGG 2 -- int10--------
    rs1402617691,2
    --75613333(+) TCACAC/TTGGGT 2 -- int10--------
    rs1879094141,2
    --75613473(+) GAAAGA/GATTCA 2 -- int10--------
    rs1897655051,2
    --75613799(+) TGGAGC/TTGTTA 2 -- int10--------
    rs1821163341,2
    --75613803(+) GTTGTC/TACAAT 2 -- int10--------
    rs1877753791,2
    --75613840(+) ATACTA/GTTAGG 2 -- int10--------
    rs1923476211,2
    --75613901(+) GATATG/TATTTT 2 -- int10--------
    rs1855280771,2
    --75614094(+) CTTGTA/GTATAA 2 -- int10--------
    rs1500153651,2
    --75614163(+) TAACAA/GAAGTA 2 -- int10--------
    rs1501297841,2
    C--75614252(+) TACAT-/AACATG 2 -- int10--------
    rs1888478401,2
    --75614508(+) CAGGAG/TGAGCC 2 -- int10--------
    rs176229481,2
    C,F,H--75614734(+) CTTTGC/TTCATG 2 -- int116Minor allele frequency- T:0.05NA NS EA 1950
    rs1452223431,2
    --75614870(+) GGCCTC/TTGCCA 2 -- int10--------
    rs1928605251,2
    --75614960(+) TGTTTA/GGAAAT 2 -- int10--------
    rs1850270531,2
    --75614967(+) AAATAG/TTGGGA 2 -- int10--------
    rs121382231,2
    C,F,A,H--75615026(+) CTCTTA/TTGAGC 2 -- int126Minor allele frequency- T:0.13NA NS EA WA 2702
    rs1424243871,2
    --75615030(+) TATGAG/TCAGGT 2 -- int10--------
    rs1885460321,2
    --75615058(+) ATTTTA/GGGAAG 2 -- int10--------
    rs1914369911,2
    --75615085(+) CACATA/GGGAAG 2 -- int10--------
    rs1464609451,2
    --75615124(+) GTAAGA/CAGCTT 2 -- int10--------
    rs1154887591,2
    --75615497(+) AAAGTG/TCTGGA 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1390141891,2
    --75615655(+) GGCTCA/GGTTGC 2 -- int10--------
    rs1836297831,2
    --75615688(+) TTGGGA/GGGTCA 2 -- int10--------
    rs1163354081,2
    F--75615918(+) ATCCTC/TTCTCA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1882503181,2
    --75616014(+) GGATTA/GGAAGT 2 -- int10--------
    rs1159821261,2
    C--75616094(+) AATGAA/GCAGGA 2 -- int10--------
    rs760241041,2
    --75616203(+) AGGGTA/TAGAGG 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1825892401,2
    --75616366(+) TATTTA/C/TTTTTT 2 -- int10--------
    rs1870982031,2
    --75616522(+) ATGCCC/TAGCTA 2 -- int10--------
    rs127264431,2
    C,A--75616562(+) TCACCG/ATGTTG 2 -- int13Minor allele frequency- A:0.00NA 6
    rs1903643531,2
    --75616635(+) GATTAC/TAGGGG 2 -- int10--------
    rs1481464781,2
    --75616667(+) AAAATA/GATTTT 2 -- int10--------
    rs66691921,2
    C,F,H--75616681(+) TAACAC/GCGGAA 2 -- int16Minor allele frequency- G:0.05NS EA WA 534
    rs1815165511,2
    --75616747(+) AGGGAA/GGGGAA 2 -- int10--------
    rs1866458931,2
    --75616787(+) TTTTGC/TTTCTT 2 -- int10--------
    rs1419219871,2
    --75616938(+) TTTAAC/TTGACT 2 -- int10--------
    rs1899299571,2
    --75616955(+) TAATGA/CGGCTG 2 -- int10--------
    rs170963121,2
    C,F,H--75617048(+) GGGACT/CAATAA 2 -- int117Minor allele frequency- C:0.03NA NS EA 2112
    rs1379586921,2
    --75617120(+) ATAATA/GTTAAA 2 -- int10--------
    rs754276991,2
    C--75617273(+) ATTTTC/TTCATT 2 -- int15Minor allele frequency- T:0.20NA WA 244
    rs1395235071,2
    --75617339(+) GCCTGC/GGAGAA 2 -- int10--------
    rs1160697021,2
    F--75617359(+) TTGGCA/CGGTAG 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1822436981,2
    --75617702(+) TACTAA/GCATGC 2 -- int10--------
    rs1459473121,2
    --75617746(+) TCACTA/GTATGT 2 -- int10--------
    rs22226781,2
    C,H--75617932(+) CTGGTC/GTGATA 2 -- int116Minor allele frequency- G:0.00NS EA NA WA CSA 551
    rs1398033251,2
    --75617952(+) TTTCAC/TGTTTC 2 -- int10--------
    rs124091451,2
    C,F,H--75617973(+) ATATGC/ATTAGT 2 -- int110Minor allele frequency- A:0.11NS EA NA 666
    rs1497492331,2
    --75617987(+) ACATTC/TGTAAT 2 -- int10--------
    rs1852404531,2
    --75618056(+) CACACC/TGCATC 2 -- int10--------
    rs1897017391,2
    --75618086(+) CATACG/TCTTTC 2 -- int10--------
    rs1841643091,2
    --75618277(+) AACATG/TGTATA 2 -- int10--------
    rs1148918061,2
    C,F--75618286(+) TATCTA/GCCTTG 2 -- int11Minor allele frequency- G:0.04WA 118
    rs1887180051,2
    --75618293(+) CTTGCA/GTGCTT 2 -- int10--------
    rs121424601,2
    C,F,A,H--75618376(+) ctttaT/Cacaaa 2 -- int117Minor allele frequency- C:0.14NS EA NA WA 2140
    rs726796891,2
    C--75618785(+) CTTTTG/TTTTTG 2 -- int10--------
    rs1484562601,2
    --75618835(+) ACCCAA/GGCTGG 2 -- int10--------
    rs1931710471,2
    --75618843(+) TGGAGC/TGCAGT 2 -- int10--------
    rs1832357621,2
    --75618854(+) GGCACA/GATCTC 2 -- int10--------
    rs1871999581,2
    --75618949(+) CCACAC/TGCAGC 2 -- int10--------
    rs1919147321,2
    --75618983(+) GACGGC/GGTTTC 2 -- int10--------
    rs127419281,2
    C,A--75619079(+) ccatcG/Acgcct 2 -- int13Minor allele frequency- A:0.00NA 6
    rs1841553431,2
    --75619196(+) GGGCTC/TGAGTG 2 -- int10--------
    rs114205531,2
    C--75619209(+) CTCCTG/-CCTCA 2 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs1883848121,2
    --75619280(+) TTAGTA/GGAGAT 2 -- int10--------
    rs1476142841,2
    --75619389(+) ACGCCA/GGGTCT 2 -- int10--------
    rs1424643391,2
    --75619438(+) TTTCAA/GTGTTG 2 -- int10--------
    rs1922449871,2
    --75619484(+) TTTACA/GCCTAA 2 -- int10--------
    rs1447058831,2
    --75619500(+) AATTTA/GTCTGG 2 -- int10--------
    rs1478811801,2
    --75619545(+) TTTCTC/GTCTTT 2 -- int10--------
    rs1415184311,2
    --75619843(+) GTCAAA/GAGGAC 2 -- int10--------
    rs1504843101,2
    --75620064(+) ATTTAC/TAAAGT 2 -- int10--------
    rs113543791,2
    C--75620077(+) GAGTG-/TTTTTT 2 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs1140569801,2
    F--75620089(+) TTTTCA/TATCAA 2 -- int11Minor allele frequency- T:0.07WA 118
    rs1164205681,2
    F--75620232(+) GCGTAT/CGTGTC 2 -- int11Minor allele frequency- C:0.09WA 118
    rs1857421481,2
    --75620264(+) AAGGCC/TGGTGG 2 -- int10--------
    rs1453872341,2
    --75620289(+) TACACA/GTTGGA 2 -- int10--------
    rs1902654101,2
    --75620334(+) ACTAGC/TGTTAG 2 -- int10--------
    rs1169632981,2
    --75620401(+) TCTATA/GGGTAT 2 -- int11Minor allele frequency- G:0.01EA 120
    rs75240201,2
    C,F,A,H--75620434(+) AGAGAA/TCAGGG 2 -- int110Minor allele frequency- T:0.15NS EA NA WA 664
    rs1819395701,2
    --75620546(+) GCTATA/GTACCC 2 -- int10--------
    rs1492165501,2
    --75620596(+) CTCTTA/GAGAGT 2 -- int10--------
    rs1433649951,2
    --75620620(+) CTTCTA/GTTTTT 2 -- int10--------
    rs1857130781,2
    --75620642(+) GCAGGA/GTGTAG 2 -- int10--------
    rs729892641,2
    C--75620835(+) CCCTTC/TGCCTC 2 -- int12Minor allele frequency- T:0.03WA 120
    rs2005275621,2
    C--75620915(+) ACTCTC/TTNNNN 2 -- int10--------
    rs1389426701,2
    --75620988(+) GATCTC/TGGCTC 2 -- int10--------
    rs615297001,2
    --75621006(+) GCTCCA/GCCTCC 2 -- int10--------
    rs1424901941,2
    --75621013(+) CTCCCA/GGGTTC 2 -- int10--------
    rs1813607141,2
    --75621069(+) CACCCA/GCCACC 2 -- int10--------
    rs115881061,2
    C,F,H--75621115(+) GGAGTG/TTCACT 2 -- int18Minor allele frequency- T:0.47NA WA CSA 15
    rs111626371,2
    C,A,H--75621125(+) TGTTTC/TAGCCA 2 -- int11Minor allele frequency- T:0.50NA 2
    rs120885321,2
    --75621130(+) tagccA/Gggatg 2 -- int10--------
    rs1508003491,2
    --75621141(+) GTCTCA/GATCTC 2 -- int10--------
    rs1853831031,2
    C--75621154(+) GACCTC/TGTGAT 2 -- int10--------
    rs1911652231,2
    --75621170(+) CGCCTC/TGGCCT 2 -- int10--------
    rs1824371151,2
    --75621184(+) AAAGTA/GCTGGG 2 -- int10--------
    rs1392255521,2
    --75621198(+) ACAGGA/CGTGAG 2 -- int10--------
    rs1122228561,2
    --75621208(+) GCCACA/C/TGCGCC 2 -- int11CSA 2