LHX8 Gene
protein-coding GIFtS : 52
GCID: GC01 P075594
LIM homeobox 8
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Aliasesfor LHX8 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases LIM Homeobox 8 1 2 Lhx71 LHX72 LIM-Homeodomain Protein Lhx82 LIM/Homeobox Protein Lhx82 LIM Homeobox Protein 83
Export aliases for LHX8 gene to outside databases Previous GC identifers: GC01P075306 GC01P073728
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Summariesfor LHX8 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for LHX8 : The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012) UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74 Function : Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity)
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Genomic Viewsfor LHX8 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the LHX8 gene promoter: HNF-4alpha2 Nkx2-5 CUTL1 YY1 Egr-4 HNF-4alpha1 AREB6 PPAR-gamma1 PPAR-gamma2 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for LHX8 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat LHX8
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.1 LHX8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P075594: view genomic region
(about GC identifiers )
Start:
75,594,119 bp from pter
End:
75,627,218 bp from pter
Size:
33,100 bases
Orientation:
plus strand
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Proteinsfor LHX8 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74 (See
protein sequence )Recommended Name: LIM/homeobox protein Lhx8 Size : 356 amino acids; 39301 Da
Subcellular location : Nucleus (Probable)Explore the universe of human proteins at neXtProt for LHX8: NX_Q68G74 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q68G74 LHX8 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts):
NP_001001933.1 NP_001243043.1 ENSEMBL proteins: ENSP00000294638 ENSP00000348597 ENSP00000453068 Human Recombinant Protein Products for LHX8: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
LHX8 for ontologies About GeneDecksing LHX8 Antibody Products: Assay Products for LHX8:
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Protein
Domains / Familiesfor LHX8 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
LHX8 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q68G74 ProtoNet protein and cluster: Q68G74
1 Blocks protein family : IPB001781 Zn-binding protein UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74 Similarity : Contains 1 homeobox DNA-binding domainSimilarity : Contains 2 LIM zinc-binding domains
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Functionfor LHX8 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: LHX8_HUMAN, Q68G74 Function : Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0008270 zinc ion binding
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
LHX8 for ontologies About GeneDecksing Phenotypes: 7 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Lhx8) :
LHX8 for phenotypes About GeneDecksing Animal Models: Mouse knock-out Lhx8 tm1Lmgd for LHX8Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for LHX8 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for LHX8OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LHX8 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat LHX8
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8
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Pathways & Interactionsfor LHX8 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LHX8 Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
LHX8 for ontologies About GeneDecksing
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Drugs & Compoundsfor LHX8 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for LHX8 Search CenterWatch for drugs/clinical trials and news about LHX8
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Transcriptsfor LHX8 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for LHX8 gene (2 alternative transcripts): NM_001001933.1 NM_001256114.1 Unigene Cluster for LHX8:
LIM homeobox 8 Hs.403934 [show with all ESTs ] Unigene Representative Sequence: BC040321 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000294638 (uc021oou.1 uc001dgo.3 ) ENST00000356261 (uc001dgq.3 )ENST00000559413 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for LHX8 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for LHX8OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LHX8 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat LHX8
Additional cDNA sequence: BC036423.1 BC040321.1
3 DOTS entries : DT.95088275 DT.92020528
DT.95222210 9 AceView cDNA sequences :
NM_001001933 BC040321 BF978460 AK094667 BG772403 BC036423 BF572867 BG709099 AA331573 GeneLoc Exon Structure
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Expression for LHX8 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section LHX8 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAAACACATTAbout this image LHX8 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See LHX8 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for LHX8 SOURCE GeneReport for Unigene cluster: Hs.403934 SABiosciences Custom PCR Arrays for LHX8 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for LHX8Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat LHX8 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat LHX8 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat LHX8 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8
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Orthologsfor LHX8 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for LHX8 gene from 5/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for LHX8 (if available)TreeFam Gene Tree for LHX8 (if available)
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Paralogsfor LHX8 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for LHX8 gene LMO2 2 ISL1 2 LHX2 2 LHX9 2 LMX1B 2 LMO1 2 LHX5 2 LMO4 2 LHX6 2 LHX1 2 LMX1A 2 LMO3 2 LHX4 2 LHX3 2 ISL2 2 18/30 SIMAP similar genes for LHX8 using alignment to 5 protein entries: LHX8_HUMAN (see all proteins )
(see all similar genes ):Lhx8 LHX6 LHX4 LIMD1 LHx4 LHX3 FBLIM1 LHX1 TES LMO4 POU6F1 ISL2 ABLIM2 WTIP LMO1 ZYX LMX1B LPP
LHX8 for paralogs About GeneDecksing
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Genomic Variantsfor LHX8 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More