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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LHX8 Gene

protein-coding GIFtS: 52
GCID: GC01P075594

LIM homeobox 8

Explore 6 diseases affiliated with
LHX8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
LIM Homeobox 8¹ ²
Lhx7¹
LHX7²
LIM-Homeodomain Protein Lhx8²
LIM/Homeobox Protein Lhx8²
LIM Homeobox Protein 8³

External Ids:	HGNC: 28838¹	Entrez Gene: 431707²	Ensembl: ENSG00000162624⁷	OMIM: 604425⁵	UniProtKB: Q68G74³

Export aliases for LHX8 gene to outside databases

Previous GC identifers: GC01P075306 GC01P073728

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LHX8:

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning

and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc

finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription

factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation.

This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative

splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74

Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LHX8 gene promoter:
HNF-4alpha2 Nkx2-5 CUTL1 YY1 Egr-4 HNF-4alpha1 AREB6 PPAR-gamma1 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LHX8 promoter sequence

Search SABiosciences Chromatin IP Primers for LHX8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.1

LHX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX8 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P075594: view genomic region (about GC identifiers)

Start:	75,594,119 bp from pter	End:	75,627,218 bp from pter
Size:	33,100 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74 (See protein sequence)

Recommended Name: LIM/homeobox protein Lhx8

Size: 356 amino acids; 39301 Da

Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for LHX8: NX_Q68G74

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q68G74

LHX8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001001933.1 NP_001243043.1

ENSEMBL proteins:

ENSP00000294638 ENSP00000348597 ENSP00000453068

Human Recombinant Protein Products for LHX8:

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	GenScript Custom Purified and Recombinant Proteins Services for LHX8
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LHX8

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

LHX8 for ontologies About GeneDecksing

LHX8 Antibody Products:

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	Novus Biologicals LHX8 Antibodies
	Abcam antibodies for LHX8
	Uscn Antibodies for LHX8
	Search ThermoFisher Antibodies for LHX8

Assay Products for LHX8:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LHX8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LHX8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LHX8 for domains About GeneDecksing

4 InterPro domains/families:

IPR001781 Znf_LIM

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q68G74

ProtoNet protein and cluster: Q68G74

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 2 LIM zinc-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LHX8_HUMAN, Q68G74

Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

LHX8 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Lhx8):

behavior/neurological	cellular	craniofacial	digestive/alimentary	growth/size
mortality/aging	nervous system

LHX8 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Lhx8^tm1Lmgd for LHX8

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LHX8

miRNA Products:		OriGene 3'-UTR Clone: LHX8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX8
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX8 (see all 46):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: LHX8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX8 (see all 7) OriGene shRNA RFP: LHX8 OriGene siRNA: LHX8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX8
		Sirion Biotech Custom design and validation of potent shRNA sequences against LHX8

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for LHX8
			Sirion Biotech Customized adenovirus for overexpression of LHX8 Sirion Biotech Customized adenovirus for potent knockdown of LHX8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX8 (see first 1) NM_001001933 (human cat#: RC207301) NM_010713 (mouse cat#: MR226908) NM_001012219 (rat cat#: RR200707) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LHX8
		LifeMap BioReagents: cell lines associated with LHX8: PureStem 4D20.8, NCr-fac Progenitor, PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
		Sirion Biotech Customized stable knockdown cell line services for LHX8 Sirion Biotech Customized inducible knockdown cell line services for LHX8 Sirion Biotech Customized stable overexpressing cell line services for LHX8 Sirion Biotech Customized inducible overexpressing cell line services for LHX8

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LHX8

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007611	learning or memory	IEA	--
GO:0008585	female gonad development	IEA	--
GO:0021879	forebrain neuron differentiation	--	--
GO:0021884	forebrain neuron development	IEA	--

LHX8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LHX8
Search CenterWatch for drugs/clinical trials and news about LHX8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LHX8 gene (2 alternative transcripts):

NM_001001933.1 NM_001256114.1

Unigene Cluster for LHX8:

LIM homeobox 8

Hs.403934 [show with all ESTs]

Unigene Representative Sequence: BC040321

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000294638(uc021oou.1 uc001dgo.3) ENST00000356261(uc001dgq.3)

ENST00000559413

miRNA Products:		OriGene 3'-UTR Clone: LHX8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX8
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX8 (see all 46):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: LHX8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX8 (see all 7) OriGene shRNA RFP: LHX8 OriGene siRNA: LHX8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX8
		Sirion Biotech Custom design and validation of potent shRNA sequences against LHX8

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX8 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LHX8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX8

Additional cDNA sequence:

BC036423.1 BC040321.1

3 DOTS entries:

DT.95088275 DT.92020528 DT.95222210

9 AceView cDNA sequences:

NM_001001933 BC040321 BF978460 AK094667 BG772403 BC036423 BF572867 BG709099

AA331573

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LHX8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAACACATT

About this image

LHX8 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Cervical Brown Adipose Depot

Cervical Brown Adipocyte Cells

Selective marker (cell-identifying gene)

Adipose

Cervical Brown Adipose Depot

Cervical Committed Brown Preadipocytes

Adipose

Lumbar Brown Adipose Depot

Lumbar Brown Adipocyte Cells

Adipose

Lumbar Brown Adipose Depot

Lumbar Committed Brown Preadipocytes

Adipose

Sacral Brown Adipose Depot

Sacral Brown Adipocyte Cells

Adipose

Sacral Brown Adipose Depot

Sacral Committed Brown Preadipocytes

Adipose

Thoracic Brown Adipose Depot

Thoracic Brown Adipocyte Cells

Adipose

Thoracic Brown Adipose Depot

Thoracic Committed Brown Preadipocytes

Adipose

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Head Mesenchyme

Prechordal Mesenchyme

Mesencephalic Neural Crest Cells

Neural Crest

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

Ovarian tissue-dissociated cells (human) (Primary Cell)

Ovary, Reproductive System

Oocytes (Oocyte formation by ...)

Human oogonial stem cells (Oocyte formation by ...)

Oocytes (Oocyte formation by ...)

See LHX8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LHX8

SOURCE GeneReport for Unigene cluster: Hs.403934

SABiosciences Custom PCR Arrays for LHX8

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LHX8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LHX8 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LHX8¹	LIM homeobox 8	87.24(n) 96.19(a)		424721 NM_001040466.1 NP_001035556.1
lizard (Anolis carolinensis)	Reptilia	LHX8⁶	--	84(a)	1 ↔ 1	GL343194.1(2994876-3018755)
zebrafish (Danio rerio)	Actinopterygii	lhx8a¹	LIM homeobox 8a	68.42(n) 77.5(a)		378959 NM_001003980.1 NP_001003980.1
fruit fly (Drosophila melanogaster)	Insecta	Awh⁶	Arrowhead	37(a)	1 → many	3L(3846206-3861692)
worm (Caenorhabditis elegans)	Secernentea	lim-4⁶	LIM domain family member (lim-4)	29(a)	1 → many	X(3869734-3873276)

ENSEMBL Gene Tree for LHX8 (if available)
TreeFam Gene Tree for LHX8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LHX8 gene

LMO2² ISL1² LHX2² LHX9² LMX1B² LMO1² LHX5² LMO4²

LHX6² LHX1² LMX1A² LMO3² LHX4² LHX3² ISL2²

18/30 SIMAP similar genes for LHX8 using alignment to 5 protein entries: LHX8_HUMAN (see all proteins) (see all similar genes):

Lhx8 LHX6 LHX4 LIMD1 LHx4 LHX3

FBLIM1 LHX1 TES LMO4 POU6F1 ISL2

ABLIM2 WTIP LMO1 ZYX LMX1B LPP

LHX8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17096289^1,2	C,F,H	--	75592165(+)	`CTGCCG/ACCTAT`	1	--	us2k¹		17		NA NS EA WA CSA	934
rs10493552^1,2	C,F,A,H	--	75592228(+)	`AAGAGC/ATTAGC`	1	--	us2k¹		17		NS NA EA WA	1026
rs142124452^1,2		--	75592391(+)	`TTTGCC/TGTGTT`	1	--	us2k¹		0	--	--	--	--
rs35954432^1,2	F	--	75592726(+)	`AGACTC/TCATCT`	1	--	us2k¹		1		NA	4
rs813834^1,2	C,H	--	75592800(-)	`GCCTAG/TAAAGG`	1	--	us2k¹ trp³		6		NS EA NA	424
rs190122677^1,2		--	75592896(+)	`TGAAGC/GAAGCC`	1	--	us2k¹		0	--	--	--	--
rs814270^1,2	H	--	75592919(-)	`GGCCAG/CACATT`	1	--	us2k¹		4		NS EA	420
rs75840963^1,2	F	--	75592932(+)	`CACACA/GCAGCA`	1	--	us2k¹		1		WA	118
rs808470^1,2	H	--	75593043(-)	`ATACAG/CGAGGC`	1	--	us2k¹		4		NS EA	420
rs181661043^1,2		--	75593138(+)	`TCGCAC/GGAGGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LHX8 (75594119 - 75627218 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LHX8
1 CNV: 97401
Human Gene Mutation Database (HGMD): LHX8

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LHX8

DNA2.0 Custom Variant and Variant Library Synthesis for LHX8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LHX8 for disorders           About GeneDecksing

OMIM gene information: 604425    OMIM disorders: --

6 diseases for LHX8:    About MalaCards

cleft palate odontoma cleft lip/palate cleft lip

premature ovarian failure neuronitis

1 disease from the University of Copenhagen DISEASES database for LHX8:

Cleft palate

Genetic Association Database (GAD): LHX8
Human Genome Epidemiology (HuGE) Navigator: LHX8 (6 documents)

Export disorders for LHX8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LHX8 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with LHX8)

Utopia: connect your pdf to the dynamic
world of online information

Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)^{1, 4} Vieira A.R.... Murray J.C. (2005)
Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. (PubMed id 9598319)^{1, 3} Kitanaka J....Wanaka A. (1998)
Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. (PubMed id 22435649)¹ Paschou P....Grigoriou M. (2012)
Pharmacological Modulation of the Hedgehog Pathway Di fferentially Affects Dorsal/Ventral Patterning in Mouse and Human Embryonic Ste m Cell Models of Telencephalic Development. (PubMed id 22204396)¹ Nat R....Dechant G. (2012)
Variation in FGF1, FOXE1, and TIMP2 genes is associat ed with nonsyndromic cleft lip with or without cleft palate. (PubMed id 21462296)¹ Nikopensius T....Metspalu A. (2011)
Oogenesis: Transcriptional regulators and mouse model s. (PubMed id 21856374)¹ Jagarlamudi K. and Rajkovic A. (2011)
Comparative study of LHX8 expression between odontoma and dental tissue-derived stem cells. (PubMed id 21143530)¹ Kim J.Y....Choung P.H. (2011)
Early evolution of the LIM homeobox gene family. (PubMed id 20082688)¹ Srivastava M....Rokhsar D.S. (2010)
Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)¹ Jugessur A....Murray J.C. (2010)
Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)¹ Nikopensius T....Metspalu A. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 431707	HGNC: 28838	AceView: LHX8	Ensembl:ENSG00000162624	euGenes: HUgn431707
ECgene: LHX8	H-InvDB: LHX8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LHX8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LHX8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LHX8 gene:
Search GeneIP for patents involving LHX8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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LHX8 Gene

LIM homeobox 8

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LHX8 Gene

LIM homeobox 8

Aliasesfor LHX8 gene

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Genomic Viewsfor LHX8 gene

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Protein Domains /Familiesfor LHX8 gene

Functionfor LHX8 gene

Pathways & Interactionsfor LHX8 gene

Drugs & Compoundsfor LHX8 gene

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Expression for LHX8 gene

Orthologsfor LHX8 gene

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Disorders / Diseasesfor LHX8 gene

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for LHX8 gene

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for LHX8 gene

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for LHX8 gene

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for LHX8 gene

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for LHX8 gene

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for LHX8 gene

Pathways & Interactions
for LHX8 gene

Drugs & Compounds
for LHX8 gene

Transcripts
for LHX8 gene

Expression
for LHX8 gene

Orthologs
for LHX8 gene

Paralogs
for LHX8 gene

Genomic Variants
for LHX8 gene

Disorders / Diseases
for LHX8 gene

Publications
for LHX8 gene

Intellectual Property
for LHX8 gene

Products
for LHX8 gene