Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LHX8 Gene

Aliases for LHX8 Gene

  • LIM Homeobox 8 2 3
  • LIM-Homeodomain Protein Lhx8 3
  • LIM/Homeobox Protein Lhx8 3
  • LIM Homeobox Protein 8 4
  • LHX7 3

External Ids for LHX8 Gene

Previous GeneCards Identifiers for LHX8 Gene

  • GC01P075306
  • GC01P075594
  • GC01P073728

Summaries for LHX8 Gene

Entrez Gene Summary for LHX8 Gene

  • The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for LHX8 Gene

LHX8 (LIM Homeobox 8) is a Protein Coding gene. Diseases associated with LHX8 include odontoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is LHX4.

UniProtKB/Swiss-Prot for LHX8 Gene

  • Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHX8 Gene

Genomics for LHX8 Gene

Regulatory Elements for LHX8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LHX8 Gene

75,128,434 bp from pter
75,161,533 bp from pter
33,100 bases
Plus strand

Genomic View for LHX8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LHX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHX8 Gene

Proteins for LHX8 Gene

  • Protein details for LHX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LIM/homeobox protein Lhx8
    Protein Accession:
    Secondary Accessions:
    • E9PGE3

    Protein attributes for LHX8 Gene

    356 amino acids
    Molecular mass:
    39301 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LHX8 Gene


neXtProt entry for LHX8 Gene

Proteomics data for LHX8 Gene at MOPED

Post-translational modifications for LHX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHX8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LHX8 Gene

Domains for LHX8 Gene

Gene Families for LHX8 Gene

  • LIM :Homeoboxes / LIM class

Protein Domains for LHX8 Gene

Suggested Antigen Peptide Sequences for LHX8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q68G74
  • Contains 1 homeobox DNA-binding domain.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with LHX8: view

Function for LHX8 Gene

Molecular function for LHX8 Gene

UniProtKB/Swiss-Prot Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Gene Ontology (GO) - Molecular Function for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with LHX8: view
genes like me logo Genes that share phenotypes with LHX8: view

Animal Models for LHX8 Gene

MGI Knock Outs for LHX8:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LHX8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LHX8 Gene

Localization for LHX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHX8 Gene

Subcellular locations from

Jensen Localization Image for LHX8 Gene COMPARTMENTS Subcellular localization image for LHX8 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001674 female germ cell nucleus IEA --
genes like me logo Genes that share ontologies with LHX8: view

Pathways for LHX8 Gene

SuperPathways for LHX8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007611 learning or memory IEA --
GO:0008585 female gonad development IEA --
GO:0021879 forebrain neuron differentiation --
genes like me logo Genes that share ontologies with LHX8: view

No data available for Pathways by source for LHX8 Gene

Transcripts for LHX8 Gene

mRNA/cDNA for LHX8 Gene

(9) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LHX8 Gene

LIM homeobox 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LHX8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LHX8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LHX8 Gene

No ASD Table

Relevant External Links for LHX8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LHX8 Gene

mRNA expression in normal human tissues for LHX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHX8 Gene

This gene is overexpressed in Minor Salivary Gland (14.3), Brain - Caudate (basal ganglia) (9.1), Brain - Putamen (basal ganglia) (7.3), Brain - Nucleus accumbens (basal ganglia) (6.4), and Brain - Hypothalamus (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LHX8 Gene

SOURCE GeneReport for Unigene cluster for LHX8 Gene Hs.403934

genes like me logo Genes that share expressions with LHX8: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LHX8 Gene

Orthologs for LHX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LHX8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LHX8 35
  • 99.63 (n)
  • 100 (a)
LHX8 36
  • 100 (a)
(Bos Taurus)
Mammalia LHX8 35
  • 95.38 (n)
  • 98.55 (a)
LHX8 36
  • 88 (a)
(Canis familiaris)
Mammalia LHX8 35
  • 95.22 (n)
  • 99.07 (a)
LHX8 36
  • 86 (a)
(Mus musculus)
Mammalia Lhx8 35
  • 87.91 (n)
  • 96.65 (a)
Lhx8 16
Lhx8 36
  • 88 (a)
(Monodelphis domestica)
Mammalia LHX8 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia LHX8 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Lhx8 35
  • 88.13 (n)
  • 97.21 (a)
(Gallus gallus)
Aves LHX8 35
  • 87.07 (n)
  • 95.89 (a)
LHX8 36
  • 88 (a)
(Anolis carolinensis)
Reptilia LHX8 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lhx8 35
  • 75.46 (n)
  • 85.22 (a)
(Danio rerio)
Actinopterygii lhx8a 35
  • 71.48 (n)
  • 82.56 (a)
lhx8a 36
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006540 35
  • 53.5 (n)
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Awh 35
  • 50.59 (n)
  • 47.79 (a)
Awh 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea lim-4 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PXL1 38
Species with no ortholog for LHX8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHX8 Gene

Gene Tree for LHX8 (if available)
Gene Tree for LHX8 (if available)

Paralogs for LHX8 Gene

Paralogs for LHX8 Gene

Selected SIMAP similar genes for LHX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LHX8: view

Variants for LHX8 Gene

Sequence variations from dbSNP and Humsavar for LHX8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs729832 -- 75,135,547(-) TCCCT(C/T)TGGAA intron-variant
rs729833 -- 75,135,460(-) CGCGG(A/G)ACCCA intron-variant
rs808470 -- 75,127,358(-) ATACA(C/G)GAGGC upstream-variant-2KB
rs811598 -- 75,139,342(+) AAACA(C/G)ACATT intron-variant
rs813834 -- 75,127,115(-) GCCTA(G/T)AAAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LHX8 Gene

Variant ID Type Subtype PubMed ID
nsv871743 CNV Gain 21882294
nsv1444 CNV Insertion 18451855
esv2632878 CNV Deletion 19546169

Relevant External Links for LHX8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX8 Gene

Disorders for LHX8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LHX8 Gene including...

Search for LHX8 Gene in MalaCards »

(2) University of Copenhagen DISEASES for LHX8 Gene

Relevant External Links for LHX8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LHX8: view

No data available for UniProtKB/Swiss-Prot for LHX8 Gene

Publications for LHX8 Gene

  1. Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. (PMID: 9598319) Kitanaka J. … Wanaka A. (Genomics 1998) 2 3
  2. Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PMID: 16327884) Vieira A.R. … Murray J.C. (PLoS Genet. 2005) 3 48
  3. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PMID: 20572854) JagomAogi T. … Metspalu A. (Eur. J. Oral Sci. 2010) 3 48
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  5. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PMID: 20672350) Nikopensius T. … Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010) 3 48

Products for LHX8 Gene

Sources for LHX8 Gene

Back to Top