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LHX8 Gene(Protein Coding)

LIM Homeobox 8

GCID:
GC01P075128
GIFtS:
50
Genes Participants
UDN Logo

Aliases for LHX8 Gene

Aliases for LHX8 Gene

  • LIM Homeobox 8 2 3 5
  • LIM-Homeodomain Protein Lhx8 3
  • LIM/Homeobox Protein Lhx8 3
  • LIM Homeobox Protein 8 4
  • LHX7 3

External Ids for LHX8 Gene

Previous GeneCards Identifiers for LHX8 Gene

  • GC01P075306
  • GC01P075594
  • GC01P073728

Summaries for LHX8 Gene

Entrez Gene Summary for LHX8 Gene

  • The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for LHX8 Gene

LHX8 (LIM Homeobox 8) is a Protein Coding gene. Diseases associated with LHX8 include Odontoma and Cleft Lip/Palate. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX6.

UniProtKB/Swiss-Prot for LHX8 Gene

  • Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHX8 Gene

Genomics for LHX8 Gene

Products:

  1. Regulatory Element

Regulatory Elements for LHX8 Gene

Enhancers for LHX8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G075125 0.6 FANTOM5 0.7 -3.1 -3149 0.4 L3MBTL2 PRDM1 RBFOX2 MGA ZNF507 SLC44A5 ENSG00000261213 LHX8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LHX8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LHX8 gene promoter:

Genomic Location for LHX8 Gene

Chromosome:
1
Start:
75,128,434 bp from pter
End:
75,161,533 bp from pter
Size:
33,100 bases
Orientation:
Plus strand

Genomic View for LHX8 Gene

Genes around LHX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHX8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LHX8 Gene

Proteins for LHX8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LHX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68G74-LHX8_HUMAN
    Recommended name:
    LIM/homeobox protein Lhx8
    Protein Accession:
    Q68G74
    Secondary Accessions:
    • E9PGE3

    Protein attributes for LHX8 Gene

    Size:
    356 amino acids
    Molecular mass:
    39301 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LHX8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LHX8 Gene

Protein Expression for LHX8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LHX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHX8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LHX8 Gene

Domains & Families for LHX8 Gene

Gene Families for LHX8 Gene

HGNC:

Protein Domains for LHX8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LHX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LHX8: view

No data available for UniProtKB/Swiss-Prot for LHX8 Gene

Function for LHX8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for LHX8 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Gene Ontology (GO) - Molecular Function for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LHX8: view
genes like me logo Genes that share phenotypes with LHX8: view

Animal Models for LHX8 Gene

MGI Knock Outs for LHX8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LHX8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LHX8 Gene

Localization for LHX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHX8 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LHX8 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001674 female germ cell nucleus IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LHX8: view

Pathways & Interactions for LHX8 Gene

SuperPathways for LHX8 Gene

PathCards logo More details on SuperPathways for LHX8
No Data Available

Gene Ontology (GO) - Biological Process for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007611 learning or memory IEA --
GO:0008585 female gonad development IEA --
GO:0021879 forebrain neuron differentiation IEA --
genes like me logo Genes that share ontologies with LHX8: view

No data available for Pathways by source and SIGNOR curated interactions for LHX8 Gene

Drugs & Compounds for LHX8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for LHX8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LHX8 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LHX8 Gene

LIM homeobox 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LHX8

Alternative Splicing Database (ASD) splice patterns (SP) for LHX8 Gene

No ASD Table

Relevant External Links for LHX8 Gene

GeneLoc Exon Structure for
LHX8
ECgene alternative splicing isoforms for
LHX8

Expression for LHX8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LHX8 Gene

mRNA expression in normal human tissues for LHX8 Gene
mRNA expression by BioGPS for LHX8 GenemRNA expression by GTEx for LHX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHX8 Gene

This gene is overexpressed in Minor Salivary Gland (x14.3), Brain - Caudate (basal ganglia) (x9.1), Brain - Putamen (basal ganglia) (x7.3), Brain - Nucleus accumbens (basal ganglia) (x6.4), and Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for LHX8 Gene

This gene is overexpressed in Pancreatic juice (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LHX8 Gene



Protein tissue co-expression partners for LHX8 Gene

NURSA nuclear receptor signaling pathways regulating expression of LHX8 Gene:

LHX8

SOURCE GeneReport for Unigene cluster for LHX8 Gene:

Hs.403934
genes like me logo Genes that share expression patterns with LHX8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LHX8 Gene

Orthologs for LHX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LHX8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LHX8 34 35
  • 99.63 (n)
cow
(Bos Taurus)
 Mammalia LHX8 34 35
  • 95.38 (n)
dog
(Canis familiaris)
 Mammalia LHX8 34 35
  • 95.22 (n)
rat
(Rattus norvegicus)
 Mammalia Lhx8 34
  • 88.13 (n)
mouse
(Mus musculus)
 Mammalia Lhx8 34 16 35
  • 87.91 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia LHX8 35
  • 87 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia LHX8 35
  • 61 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LHX8 34 35
  • 87.07 (n)
lizard
(Anolis carolinensis)
 Reptilia LHX8 35
  • 84 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia lhx8 34
  • 75.46 (n)
zebrafish
(Danio rerio)
 Actinopterygii lhx8a 34 35
  • 71.48 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006540 34
  • 53.5 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Awh 34 35
  • 50.59 (n)
worm
(Caenorhabditis elegans)
 Secernentea lim-4 35
  • 32 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PXL1 37
Species where no ortholog for LHX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHX8 Gene

ENSEMBL:
Gene Tree for LHX8 (if available)
TreeFam:
Gene Tree for LHX8 (if available)

Paralogs for LHX8 Gene

Paralogs for LHX8 Gene

(28) SIMAP similar genes for LHX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LHX8: view

Variants for LHX8 Gene

Sequence variations from dbSNP and Humsavar for LHX8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000027947 -- 75,145,546(+) CAGGC(A/T)TTTAT intron-variant
rs1000178763 -- 75,138,678(+) GACCT(A/G)TGAAG intron-variant
rs1000191102 -- 75,129,771(+) GATGT(G/T)GAAGG intron-variant
rs1000193912 -- 75,182,625(+) ACCTC(A/G)GCCTC intron-variant
rs1000251056 -- 75,138,345(+) GTTTC(C/T)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHX8 Gene

Variant ID Type Subtype PubMed ID
esv2632878 CNV deletion 19546169
nsv1078876 OTHER inversion 25765185
nsv1444 CNV insertion 18451855

Variation tolerance for LHX8 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LHX8 Gene

Human Gene Mutation Database (HGMD)
LHX8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LHX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX8 Gene

Disorders for LHX8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LHX8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
odontoma
cleft lip/palate
  • alveolar cleft lip and palate
- elite association - COSMIC cancer census association via MalaCards
Search LHX8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LHX8

Genetic Association Database (GAD)
LHX8
Human Genome Epidemiology (HuGE) Navigator
LHX8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LHX8
genes like me logo Genes that share disorders with LHX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHX8 Gene

Publications for LHX8 Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  2. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PMID: 20672350) Nikopensius T. … Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010) 3 46 64
  3. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PMID: 20572854) JagomAogi T. … Metspalu A. (Eur. J. Oral Sci. 2010) 3 46 64
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 46 64
  5. Analysis of LHX8 mutation in premature ovarian failure. (PMID: 17624344) Qin Y. … Rajkovic A. (Fertil. Steril. 2008) 3 46 64

Products for LHX8 Gene

Sources for LHX8 Gene

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