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Set Analyses:

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LHX8 Gene

protein-coding GIFtS: 51
GCID: GC01P075594

LIM Homeobox 8

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
LIM Homeobox 8¹ ²
LHX7²
LIM-Homeodomain Protein Lhx8²
LIM/Homeobox Protein Lhx8²
LIM Homeobox Protein 8³

External Ids:	HGNC: 28838¹	Entrez Gene: 431707²	Ensembl: ENSG00000162624⁷	OMIM: 604425⁵	UniProtKB: Q68G74³

Export aliases for LHX8 gene to outside databases

Previous GC identifers: GC01P075306 GC01P073728

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LHX8 Gene:

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in

patterning and differentiation of various tissue types. These proteins contain two tandemly repeated

cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This

family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in

oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also

associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants.

(provided by RefSeq, Jan 2012)

GeneCards Summary for LHX8 Gene:

LHX8 (LIM homeobox 8) is a protein-coding gene. Diseases associated with LHX8 include odontoma, and cleft palate. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74

Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NC_018912.2 NT_032977.10

Regulatory elements:

Regulatory transcription factor binding sites in the LHX8 gene promoter:
HNF-4alpha2 Nkx2-5 CUTL1 YY1 Egr-4 HNF-4alpha1 AREB6 PPAR-gamma1 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LHX8 promoter sequence

Search Chromatin IP Primers for LHX8

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHX8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.1

LHX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX8 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P075594: view genomic region (about GC identifiers)

Start:	75,594,119 bp from pter	End:	75,627,218 bp from pter
Size:	33,100 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74 (See protein sequence)

Recommended Name: LIM/homeobox protein Lhx8

Size: 356 amino acids; 39301 Da

Secondary accessions: E9PGE3

Alternative splicing: 2 isoforms: Q68G74-1 Q68G74-2 (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for LHX8: NX_Q68G74

Explore proteomics data for LHX8 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See LHX8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001001933.1 NP_001243043.1

ENSEMBL proteins:

ENSP00000294638 ENSP00000348597

LHX8 Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for LHX8

LHX8 Antibody Products:

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	Novus Biologicals LHX8 Antibodies
	Search for Antibodies for LHX8 at Abcam
	Cloud-Clone Corp. Antibodies for LHX8
	ThermoFisher Antibodies for LHX8
	LSBio Antibodies in human, mouse, rat for LHX8

LHX8 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for LHX8
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LHX8
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for LHX8 Cloud-Clone Corp. CLIAs for LHX8

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

LIM: Homeoboxes / LIM class

4 InterPro protein domains:

IPR001781 Znf_LIM

IPR017970 Homeobox_CS

IPR001356 Homeobox_dom

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q68G74

ProtoNet protein and cluster: Q68G74

1 Blocks protein domain: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 2 LIM zinc-binding domains

LHX8 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: LHX8_HUMAN, Q68G74

Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By

similarity)

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

LHX8 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Lhx8):

behavior/neurological	cellular	craniofacial	digestive/alimentary	growth/size/body
mortality/aging	nervous system

LHX8 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Lhx8^tm1Lmgd for LHX8

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LHX8

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LHX8

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHX8

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHX8

miRNA Products:		Block miRNA regulation of human, mouse, rat LHX8 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate LHX8 (see all 46):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: LHX8 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for LHX8
		Predesigned siRNA for gene silencing in human, mouse, rat LHX8

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LHX8

Clone Products:		OriGene clones in human, mouse for LHX8 (see all 6) OriGene ORF clones in mouse, rat for LHX8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
		Sino Biological Human cDNA Clone for LHX8
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LHX8
		ESI BIO PureStem Progenitors for LHX8: PureStem 4D20.8, NCr-fac Progenitor, PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

LHX8_HUMAN, Q68G74: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

LHX8 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for LHX8
Interactions:

Search GeneGlobe Interaction Network for LHX8

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for LHX8 (ENSP00000294638⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LHX9	ENSP00000356357⁴	STRING: ENSP00000356357
LDB1	ENSP00000392466⁴	STRING: ENSP00000392466
LDB2	ENSP00000306772⁴	STRING: ENSP00000306772
LHX3	ENSP00000360811⁴	STRING: ENSP00000360811
LHX4	ENSP00000263726⁴	STRING: ENSP00000263726

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Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0007611	learning or memory	IEA	--
GO:0008585	female gonad development	IEA	--
GO:0021879	forebrain neuron differentiation	--	--

LHX8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for LHX8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for LHX8 gene (2 alternative transcripts):

NM_001001933.1 NM_001256114.1

Unigene Cluster for LHX8:

LIM homeobox 8

Hs.403934 [show with all ESTs]

Unigene Representative Sequence: BC040321

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000294638(uc021oou.1 uc001dgo.3) ENST00000356261(uc001dgq.3)

ENST00000559413 ENST00000607240

miRNA Products:		Block miRNA regulation of human, mouse, rat LHX8 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate LHX8 (see all 46):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: LHX8 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for LHX8
		Predesigned siRNA for gene silencing in human, mouse, rat LHX8

Clone Products:		OriGene clones in human, mouse for LHX8 (see all 6) OriGene ORF clones in mouse, rat for LHX8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for LHX8
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat LHX8
		QuantiTect SYBR Green Assays in human, mouse, rat LHX8
		QuantiFast Probe-based Assays in human, mouse, rat LHX8

Additional mRNA sequence:

BC036423.1 BC040321.1

3 DOTS entries:

DT.95088275 DT.92020528 DT.95222210

9 AceView cDNA sequences:

BC040321 NM_001001933 BF978460 BC036423 BG772403 AK094667 BG709099 BF572867

AA331573

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LHX8 expression in normal human tissues (normalized intensities) LHX8 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAAACACATT

About this image

LHX8 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 16) fully expand


Adipose (Muscoskeletal System) fully expand to see all 8 entries
Sacral Brown Adipocyte Cells Sacral Brown Adipose Depot

Brain (Nervous System) fully expand to see all 8 entries
Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
Cerebellum

Neural Crest (Gastrulation Derivatives) fully expand to see all 3 entries
Cranial Neural Crest Cells Branchial Arch 1
PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian tissue-dissociated cells (human)
Oocytes

Neural Tube (Nervous System) fully expand to see all 6 entries
Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
Telencephalon

LHX8 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

LHX8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.403934

Custom PCR Arrays for LHX8

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for LHX8
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat LHX8
		QuantiTect SYBR Green Assays in human, mouse, rat LHX8
		QuantiFast Probe-based Assays in human, mouse, rat LHX8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LHX8 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lhx8^{1 , 5}	LIM homeobox protein 8^{1, 5}	87.91(n)¹ 96.65(a)¹		3 (79.12 cM)⁵ 16875¹ NM_010713.2¹ NP_034843.2¹ 154306288⁵
chicken (Gallus gallus)	Aves	LHX8¹	LIM homeobox 8	87.07(n) 95.89(a)		424721 NM_001040466.2 NP_001035556.1
lizard (Anolis carolinensis)	Reptilia	LHX8⁶	LIM homeobox 8	84(a)	1 ↔ 1	GL343194.1(2994192-3019747)
tropical clawed frog (Xenopus tropicalis)	Amphibia	lhx8¹	LIM homeobox 8	75.46(n) 85.22(a)		548653 NM_001015899.1 NP_001015899.1
zebrafish (Danio rerio)	Actinopterygii	lhx8a¹	LIM homeobox 8a	71.48(n) 82.56(a)		378959 NM_001003980.2 NP_001003980.1
fruit fly (Drosophila melanogaster)	Insecta	Awh¹	Arrowhead	50.59(n) 47.79(a)		38451 NM_168042.2 NP_728906.1
worm (Caenorhabditis elegans)	Secernentea	lim-4⁶	Protein LIM-4 (lim-4) mRNA, complete cds	32(a)	1 → many	X(3869753-3873295) WBGene00002987

ENSEMBL Gene Tree for LHX8 (if available)
TreeFam Gene Tree for LHX8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for LHX8 gene

ISL1² LHX2² LHX9² LMX1B² LHX5² LHX6² LHX1² LMX1A²

LHX4² LHX3² ISL2²

Selected SIMAP similar genes for LHX8 using alignment to 3 protein entries: LHX8_HUMAN (see all proteins) (see all similar genes):

Lhx8 LHX6 LHX4 LIMD1 LHX1 LHX3

LHx4 TES LMO3 LMO4 POU6F1 LMO1

ISL2 WTIP ZYX LMX1B LHX9 LPP

LHX8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144728419^1,2	C	untested¹	75622667(+)	`CCCTCC/TAGGCT`	4	S	syn¹		1		NA	4552
rs17096289^1,2	C,F,H	--	75592165(+)	`CTGCCG/ACCTAT`	1	--	us2k¹		17		NA NS EA WA CSA	934
rs10493552^1,2	C,F,A,H	--	75592228(+)	`AAGAGC/ATTAGC`	1	--	us2k¹		17		NS NA EA WA	1026
rs142124452^1,2		--	75592391(+)	`TTTGCC/TGTGTT`	1	--	us2k¹		0	--	--	--	--
rs35954432^1,2	F	--	75592726(+)	`AGACTC/TCATCT`	1	--	us2k¹		1		NA	4
rs813834^1,2	C,H	--	75592800(-)	`GCCTAG/TAAAGG`	1	--	us2k¹ trp³		6		NS EA NA	424
rs190122677^1,2		--	75592896(+)	`TGAAGC/GAAGCC`	1	--	us2k¹		0	--	--	--	--
rs814270^1,2	H	--	75592919(-)	`GGCCAG/CACATT`	1	--	us2k¹		4		NS EA	420
rs75840963^1,2	F	--	75592932(+)	`CACACA/GCAGCA`	1	--	us2k¹		1		WA	118
rs808470^1,2	H	--	75593043(-)	`ATACAG/CGAGGC`	1	--	us2k¹		4		NS EA	420

HapMap Linkage Disequilibrium report for LHX8 (75594119 - 75627218 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for LHX8: About this table

Variant ID	Type	Subtype	PubMed ID
esv2632878	CNV	Deletion	19546169
nsv1444	CNV	Insertion	18451855
nsv871743	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): LHX8

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing LHX8

DNA2.0 Custom Variant and Variant Library Synthesis for LHX8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604425 OMIM disorders: --

9 diseases for LHX8: About MalaCards

odontoma cleft palate premature ovarian failure cleft lip

neuronitis cervicitis malaria cerebritis

endotheliitis

2 diseases from the University of Copenhagen DISEASES database for LHX8:

Cleft palate Premature ovarian failure

LHX8 for disorders About GeneDecksing

Genetic Association Database (GAD): LHX8
Human Genome Epidemiology (HuGE) Navigator: LHX8 (6 documents)

Export disorders for LHX8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LHX8 gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with LHX8)

Utopia: connect your pdf to the dynamic
world of online information

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)^{1, 4} Jugessur A....Murray J.C. (PLoS ONE 2010)
Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)^{1, 4} Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)^{1, 4} JagomAogi T....Metspalu A. (Eur. J. Oral Sci. 2010)
Analysis of LHX8 mutation in premature ovarian failure. (PubMed id 17624344)^{1, 4} Qin Y....Rajkovic A. (Fertil. Steril. 2008)
Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)^{1, 4} Vieira A.R....Marazita M.L. (Genet. Med. 2008)
Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)^{1, 4} Vieira A.R.... Murray J.C. (PLoS Genet. 2005)
Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. (PubMed id 9598319)^{1, 3} Kitanaka J....Wanaka A. (Genomics 1998)
A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)¹ Weimann M.... Stelzl U. (Nat. Methods 2013)
Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. (PubMed id 22435649)¹ Paschou P....Grigoriou M. (Genes Brain Behav. 2012)
Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development. (PubMed id 22204396)¹ Nat R....Dechant G. (Stem Cells Dev. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 431707	HGNC: 28838	AceView: LHX8	Ensembl:ENSG00000162624	euGenes: HUgn431707
ECgene: LHX8	H-InvDB: LHX8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LHX8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LHX8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LHX8 gene:
Search GeneIP for patents involving LHX8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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LHX8 Gene

LIM Homeobox 8

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LHX8 Gene

LIM Homeobox 8

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