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LHX8 Gene(Protein Coding)

LIM Homeobox 8

GCID:
GC01P075128
GIFtS:
46
Genes Participants
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Aliases for LHX8 Gene

Aliases for LHX8 Gene

  • LIM Homeobox 8 2 3 5
  • LIM-Homeodomain Protein Lhx8 3
  • LIM/Homeobox Protein Lhx8 3
  • LIM Homeobox Protein 8 4
  • LHX7 3

External Ids for LHX8 Gene

Previous GeneCards Identifiers for LHX8 Gene

  • GC01P075306
  • GC01P075594
  • GC01P073728

Summaries for LHX8 Gene

Entrez Gene Summary for LHX8 Gene

  • The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for LHX8 Gene

LHX8 (LIM Homeobox 8) is a Protein Coding gene. Diseases associated with LHX8 include Odontoma and Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX6.

UniProtKB/Swiss-Prot for LHX8 Gene

  • Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Additional gene information for LHX8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHX8 Gene

Genomics for LHX8 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for LHX8 Gene

Promoters and enhancers for LHX8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I075137 Promoter 0.9 EPDnew 550.4 +7.9 7935 0.1 PKNOX1 ZBTB6 ZNF189 ZNF223 SIN3A ZBTB8A ZNF335 CTBP2 ZBTB26 ZBTB17 LHX8 ENSG00000224127 GC01M075131
GH01I075128 Promoter 0.7 EPDnew 550.8 +0.0 2 0.1 CTCF EZH2 LHX8 ENSG00000224127 ENSG00000224149
GH01I075134 Promoter 0.7 EPDnew 550.4 +6.4 6432 0.1 L3MBTL2 SUZ12 EZH2 ENSG00000224127 LHX8 GC01M075131
GH01I075125 Enhancer 0.5 FANTOM5 0.8 -3.1 -3149 0.4 AFF1 L3MBTL2 MGA ENSG00000261213 SLC44A5 LHX8
GH01I075136 Enhancer 0.6 ENCODE 0.4 +8.2 8217 0.2 L3MBTL2 ZNF189 SIN3A ZBTB8A CTBP2 ZBTB26 EZH2 ZBTB20 SLC44A5 ENSG00000224127 GC01M075131 LHX8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LHX8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LHX8 gene promoter:

Genomic Locations for LHX8 Gene

Genomic Locations for LHX8 Gene
chr1:75,128,434-75,161,533
(GRCh38/hg38)
Size:
33,100 bases
Orientation:
Plus strand
chr1:75,594,119-75,627,218
(GRCh37/hg19)

Genomic View for LHX8 Gene

Genes around LHX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHX8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LHX8 Gene

Proteins for LHX8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LHX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68G74-LHX8_HUMAN
    Recommended name:
    LIM/homeobox protein Lhx8
    Protein Accession:
    Q68G74
    Secondary Accessions:
    • E9PGE3

    Protein attributes for LHX8 Gene

    Size:
    356 amino acids
    Molecular mass:
    39301 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LHX8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LHX8 Gene

Protein Expression for LHX8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LHX8 Gene

No Post-translational modifications

Other Protein References for LHX8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LHX8 Gene

Domains & Families for LHX8 Gene

Gene Families for LHX8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for LHX8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LHX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LHX8: view

No data available for UniProtKB/Swiss-Prot for LHX8 Gene

Function for LHX8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for LHX8 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Phenotypes From GWAS Catalog for LHX8 Gene

Gene Ontology (GO) - Molecular Function for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LHX8: view
genes like me logo Genes that share phenotypes with LHX8: view

Animal Models for LHX8 Gene

MGI Knock Outs for LHX8:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LHX8 Gene

Localization for LHX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHX8 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LHX8 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001674 female germ cell nucleus IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LHX8: view

Pathways & Interactions for LHX8 Gene

SuperPathways for LHX8 Gene

PathCards logo More details on SuperPathways for LHX8
No Data Available

Gene Ontology (GO) - Biological Process for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007611 learning or memory IEA --
GO:0008585 female gonad development IEA --
GO:0021879 forebrain neuron differentiation IEA --
genes like me logo Genes that share ontologies with LHX8: view

No data available for Pathways by source and SIGNOR curated interactions for LHX8 Gene

Drugs & Compounds for LHX8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for LHX8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LHX8 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LHX8 Gene

LIM homeobox 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LHX8 Gene

No ASD Table

Relevant External Links for LHX8 Gene

GeneLoc Exon Structure for
LHX8
ECgene alternative splicing isoforms for
LHX8

Expression for LHX8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LHX8 Gene

mRNA expression in normal human tissues for LHX8 Gene
mRNA expression by GTEx for LHX8 GenemRNA expression by BioGPS for LHX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHX8 Gene

This gene is overexpressed in Minor Salivary Gland (x14.3), Brain - Caudate (basal ganglia) (x9.1), Brain - Putamen (basal ganglia) (x7.3), Brain - Nucleus accumbens (basal ganglia) (x6.4), and Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for LHX8 Gene

This gene is overexpressed in Pancreatic juice (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LHX8 Gene



Protein tissue co-expression partners for LHX8 Gene

NURSA nuclear receptor signaling pathways regulating expression of LHX8 Gene:

LHX8

SOURCE GeneReport for Unigene cluster for LHX8 Gene:

Hs.403934
genes like me logo Genes that share expression patterns with LHX8: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LHX8 Gene

Orthologs for LHX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LHX8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LHX8 33 34
  • 99.63 (n)
cow
(Bos Taurus)
 Mammalia LHX8 33 34
  • 95.38 (n)
dog
(Canis familiaris)
 Mammalia LHX8 33 34
  • 95.22 (n)
rat
(Rattus norvegicus)
 Mammalia Lhx8 33
  • 88.13 (n)
mouse
(Mus musculus)
 Mammalia Lhx8 33 16 34
  • 87.91 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia LHX8 34
  • 87 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia LHX8 34
  • 61 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LHX8 33 34
  • 87.07 (n)
lizard
(Anolis carolinensis)
 Reptilia LHX8 34
  • 84 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia lhx8 33
  • 75.46 (n)
zebrafish
(Danio rerio)
 Actinopterygii lhx8a 33 34
  • 71.48 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006540 33
  • 53.5 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Awh 33 34
  • 50.59 (n)
worm
(Caenorhabditis elegans)
 Secernentea lim-4 34
  • 32 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PXL1 36
Species where no ortholog for LHX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHX8 Gene

ENSEMBL:
Gene Tree for LHX8 (if available)
TreeFam:
Gene Tree for LHX8 (if available)

Paralogs for LHX8 Gene

Paralogs for LHX8 Gene

(28) SIMAP similar genes for LHX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LHX8: view

Variants for LHX8 Gene

Sequence variations from dbSNP and Humsavar for LHX8 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000027947 -- 75,145,546(+) A/T intron_variant
rs1000178763 -- 75,138,678(+) A/G intron_variant
rs1000191102 -- 75,129,771(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000193912 -- 75,182,625(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000251056 -- 75,138,345(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LHX8 Gene

Variant ID Type Subtype PubMed ID
esv2632878 CNV deletion 19546169
nsv1078876 OTHER inversion 25765185
nsv1444 CNV insertion 18451855

Variation tolerance for LHX8 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LHX8 Gene

Human Gene Mutation Database (HGMD)
LHX8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LHX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX8 Gene

Disorders for LHX8 Gene

MalaCards: The human disease database

(6) MalaCards diseases for LHX8 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search LHX8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for LHX8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with LHX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHX8 Gene

Publications for LHX8 Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
  2. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PMID: 20672350) Nikopensius T … Metspalu A (Birth defects research. Part A, Clinical and molecular teratology 2010) 3 44 58
  3. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PMID: 20572854) Jagomägi T … Metspalu A (European journal of oral sciences 2010) 3 44 58
  4. Analysis of LHX8 mutation in premature ovarian failure. (PMID: 17624344) Qin Y … Rajkovic A (Fertility and sterility 2008) 3 44 58
  5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58

Products for LHX8 Gene

Sources for LHX8 Gene

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