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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LHX8 Gene

protein-coding GIFtS: 52
GCID: GC01P075594

LIM Homeobox 8

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
LIM Homeobox 8¹ ²
LHX7²
LIM-Homeodomain Protein Lhx8²
LIM/Homeobox Protein Lhx8²
LIM Homeobox Protein 8³

External Ids:	HGNC: 28838¹	Entrez Gene: 431707²	Ensembl: ENSG00000162624⁷	OMIM: 604425⁵	UniProtKB: Q68G74³

Export aliases for LHX8 gene to outside databases

Previous GC identifers: GC01P075306 GC01P073728

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LHX8 Gene:

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in

patterning and differentiation of various tissue types. These proteins contain two tandemly repeated

cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This

family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in

oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also

associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants.

(provided by RefSeq, Jan 2012)

GeneCards Summary for LHX8 Gene:

LHX8 (LIM homeobox 8) is a protein-coding gene. Diseases associated with LHX8 include odontoma, and cleft palate. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74

Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.2 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LHX8 gene promoter:
HNF-4alpha2 Nkx2-5 CUTL1 YY1 Egr-4 HNF-4alpha1 AREB6 PPAR-gamma1 PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LHX8 promoter sequence

Search SABiosciences Chromatin IP Primers for LHX8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.1

LHX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX8 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P075594: view genomic region (about GC identifiers)

Start:	75,594,119 bp from pter	End:	75,627,218 bp from pter
Size:	33,100 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74 (See protein sequence)

Recommended Name: LIM/homeobox protein Lhx8

Size: 356 amino acids; 39301 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: E9PGE3

Alternative splicing: 2 isoforms: Q68G74-1 Q68G74-2 (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for LHX8: NX_Q68G74

Explore proteomics data for LHX8 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q68G74

LHX8 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001001933.1 NP_001243043.1

ENSEMBL proteins:

ENSP00000294638 ENSP00000348597

Human Recombinant Protein Products for LHX8:

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	Cloud-Clone Corp. Proteins for LHX8

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

LHX8 for ontologies About GeneDecksing

LHX8 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	LSBio Antibodies in human, mouse, rat for LHX8

Assay Products for LHX8:

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	GenScript Custom Assay Services for LHX8
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	Cloud-Clone Corp. ELISAs for LHX8 Cloud-Clone Corp. CLIAs for LHX8

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

LIM: Homeoboxes / LIM class

4 InterPro protein domains:

IPR001781 Znf_LIM

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q68G74

ProtoNet protein and cluster: Q68G74

1 Blocks protein domain: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 2 LIM zinc-binding domains

LHX8 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LHX8_HUMAN, Q68G74

Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By

similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

LHX8 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Lhx8):

behavior/neurological	cellular	craniofacial	digestive/alimentary	growth/size
mortality/aging	nervous system

LHX8 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Lhx8^tm1Lmgd for LHX8

inGenious Targeting Laboratory - Custom generated mouse model solutions for LHX8

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LHX8

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHX8

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHX8

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX8
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX8 (see all 46):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: LHX8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for LHX8
			Sirion Biotech Customized adenovirus for overexpression of LHX8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for LHX8 (see all 7) OriGene ORF clones in mouse, rat for LHX8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LHX8
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LHX8

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007611	learning or memory	IEA	--
GO:0008585	female gonad development	IEA	--
GO:0021879	forebrain neuron differentiation	--	--

LHX8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LHX8

Search CenterWatch for drugs/clinical trials and news about LHX8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LHX8 gene (2 alternative transcripts):

NM_001001933.1 NM_001256114.1

Unigene Cluster for LHX8:

LIM homeobox 8

Hs.403934 [show with all ESTs]

Unigene Representative Sequence: BC040321

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000294638(uc021oou.1 uc001dgo.3) ENST00000356261(uc001dgq.3)

ENST00000559413 ENST00000607240

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX8
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX8 (see all 46):
		hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: LHX8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for LHX8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX8

Clone Products:		OriGene clones in human, mouse for LHX8 (see all 7) OriGene ORF clones in mouse, rat for LHX8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8
		Sirion Biotech Customized lentivirus for stable overexpression of LHX8 Customized lentivirus expression plasmids for stable overexpression of LHX8

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for LHX8
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LHX8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX8

Additional mRNA sequence:

BC036423.1 BC040321.1

3 DOTS entries:

DT.95088275 DT.92020528 DT.95222210

9 AceView cDNA sequences:

NM_001001933 BC040321 BF978460 AK094667 BC036423 BG772403 BG709099 BF572867

AA331573

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LHX8 expression in normal human tissues (normalized intensities) LHX8 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAAACACATT

About this image

LHX8 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/23 selected tissues (see all 23) fully expand


Brain (Nervous System) fully expand to see all 20 entries
Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
Thalamus
Septum

Adipose (Muscoskeletal System) fully expand to see all 8 entries
Sacral Brown Adipocyte Cells Sacral Brown Adipose Depot

Neural Tube (Nervous System) fully expand to see all 6 entries
Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
Telencephalon

Skeletal Muscle (Muscoskeletal System) fully expand to see all 6 entries
Mononuclear Myocytes Hyoid Arch Muscles

Tooth
Dental Papilla Cells Dental Papilla
Dental pulp Stem Cells (DPSC)
mouse/organ system/integumental system

See LHX8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LHX8

SOURCE GeneReport for Unigene cluster: Hs.403934

SABiosciences Custom PCR Arrays for LHX8

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for LHX8
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LHX8
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LHX8 gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lhx8^{1 , 5}	LIM homeobox protein 8^{1, 5}	87.91(n)¹ 96.65(a)¹		3 (79.12 cM)⁵ 16875¹ NM_010713.2¹ NP_034843.2¹ 154306288⁵
chicken (Gallus gallus)	Aves	LHX8¹	LIM homeobox 8	87.24(n) 96.19(a)		424721 NM_001040466.1 NP_001035556.1
lizard (Anolis carolinensis)	Reptilia	LHX8⁶	LIM homeobox 8	84(a)	1 ↔ 1	GL343194.1(2994192-3019747)
zebrafish (Danio rerio)	Actinopterygii	lhx8a¹	LIM homeobox 8a	68.42(n) 77.5(a)		378959 NM_001003980.1 NP_001003980.1
fruit fly (Drosophila melanogaster)	Insecta	Awh⁶	Arrowhead	37(a)	1 → many	3L(3846206-3861692)
worm (Caenorhabditis elegans)	Secernentea	lim-4⁶	Protein LIM-4	31(a)	1 → many	X(3869753-3873295)

ENSEMBL Gene Tree for LHX8 (if available)
TreeFam Gene Tree for LHX8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LHX8 gene

ISL1² LMO2² LHX2² LHX9² LMX1B² LHX5² LMO1² LHX6²

LMO4² LHX1² LMX1A² LMO3² LHX3² LHX4² ISL2²

18/30 SIMAP similar genes for LHX8 using alignment to 4 protein entries: LHX8_HUMAN (see all proteins) (see all similar genes):

Lhx8 LHX6 LHX4 LIMD1 LHX1 LHX3

LHx4 TES LMO4 POU6F1 ISL2 ABLIM2

ISL1 WTIP LMO1 ZYX LMX1B LHX9

LHX8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144728419^1,2	C	untested¹	75622667(+)	`CCCTCC/TAGGCT`	4	S	syn¹		1		NA	4552
rs17096289^1,2	C,F,H	--	75592165(+)	`CTGCCG/ACCTAT`	1	--	us2k¹		17		NA NS EA WA CSA	934
rs10493552^1,2	C,F,A,H	--	75592228(+)	`AAGAGC/ATTAGC`	1	--	us2k¹		17		NS NA EA WA	1026
rs142124452^1,2		--	75592391(+)	`TTTGCC/TGTGTT`	1	--	us2k¹		0	--	--	--	--
rs35954432^1,2	F	--	75592726(+)	`AGACTC/TCATCT`	1	--	us2k¹		1		NA	4
rs813834^1,2	C,H	--	75592800(-)	`GCCTAG/TAAAGG`	1	--	us2k¹ trp³		6		NS EA NA	424
rs190122677^1,2		--	75592896(+)	`TGAAGC/GAAGCC`	1	--	us2k¹		0	--	--	--	--
rs814270^1,2	H	--	75592919(-)	`GGCCAG/CACATT`	1	--	us2k¹		4		NS EA	420
rs75840963^1,2	F	--	75592932(+)	`CACACA/GCAGCA`	1	--	us2k¹		1		WA	118
rs808470^1,2	H	--	75593043(-)	`ATACAG/CGAGGC`	1	--	us2k¹		4		NS EA	420

HapMap Linkage Disequilibrium report for LHX8 (75594119 - 75627218 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for LHX8: About this table

Variant ID	Type	Subtype	PubMed ID
esv2632878	CNV	Deletion	19546169
nsv1444	CNV	Insertion	18451855
nsv871743	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): LHX8

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing LHX8

DNA2.0 Custom Variant and Variant Library Synthesis for LHX8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 604425 OMIM disorders: --

5 diseases for LHX8: About MalaCards

odontoma cleft palate premature ovarian failure cleft lip

neuronitis

2 diseases from the University of Copenhagen DISEASES database for LHX8:

Cleft palate Premature ovarian failure

LHX8 for disorders About GeneDecksing

Genetic Association Database (GAD): LHX8
Human Genome Epidemiology (HuGE) Navigator: LHX8 (6 documents)

Export disorders for LHX8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LHX8 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with LHX8)

Utopia: connect your pdf to the dynamic
world of online information

Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)^{1, 4} Jugessur A....Murray J.C. (2010)
Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)^{1, 4} Nikopensius T....Metspalu A. (2010)
MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)^{1, 4} JagomAogi T....Metspalu A. (2010)
Analysis of LHX8 mutation in premature ovarian failure. (PubMed id 17624344)^{1, 4} Qin Y....Rajkovic A. (2008)
Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)^{1, 4} Vieira A.R....Marazita M.L. (2008)
Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)^{1, 4} Vieira A.R.... Murray J.C. (2005)
Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. (PubMed id 9598319)^{1, 3} Kitanaka J....Wanaka A. (1998)
A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)¹ Weimann M.... Stelzl U. (2013)
Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. (PubMed id 22435649)¹ Paschou P....Grigoriou M. (2012)
Pharmacological Modulation of the Hedgehog Pathway Di fferentially Affects Dorsal/Ventral Patterning in Mouse and Human Embryonic Ste m Cell Models of Telencephalic Development. (PubMed id 22204396)¹ Nat R....Dechant G. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 431707	HGNC: 28838	AceView: LHX8	Ensembl:ENSG00000162624	euGenes: HUgn431707
ECgene: LHX8	H-InvDB: LHX8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LHX8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LHX8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LHX8 gene:
Search GeneIP for patents involving LHX8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Cell Lines associated with LHX8: PureStem 4D20.8, NCr-fac Progenitor,
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LHX8 gene at Home site.

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LHX8 Gene

LIM Homeobox 8

Aliases
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Genomic Views
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Proteins
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Protein Domains /
Families
for LHX8 gene

Function
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Pathways & Interactions
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Drugs & Compounds
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Transcripts
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Expression
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Orthologs
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Paralogs
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Genomic Variants
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Disorders / Diseases
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Publications
for LHX8 gene

External Searches for LHX8 gene

Genome Databases showing LHX8 gene

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Intellectual Property
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Export list of displayed genes

LHX8 Gene

LIM Homeobox 8

Aliasesfor LHX8 gene

Summariesfor LHX8 gene

Genomic Viewsfor LHX8 gene

Proteinsfor LHX8 gene

Protein Domains /Familiesfor LHX8 gene

Functionfor LHX8 gene

Pathways & Interactionsfor LHX8 gene

Drugs & Compoundsfor LHX8 gene

Transcriptsfor LHX8 gene

Expression for LHX8 gene

Orthologsfor LHX8 gene

Paralogsfor LHX8 gene

Genomic Variantsfor LHX8 gene

Disorders / Diseasesfor LHX8 gene

Publicationsfor LHX8 gene

External Searches for LHX8 gene

Genome Databases showing LHX8 gene

Other Databases showing LHX8 gene

Specialized Databases showing LHX8 gene

Intellectual Propertyfor LHX8 gene

Productsfor LHX8 gene

View Random Gene

Aliases
for LHX8 gene

Summaries
for LHX8 gene

Genomic Views
for LHX8 gene

Proteins
for LHX8 gene

Protein Domains /
Families
for LHX8 gene

Function
for LHX8 gene

Pathways & Interactions
for LHX8 gene

Drugs & Compounds
for LHX8 gene

Transcripts
for LHX8 gene

Expression
for LHX8 gene

Orthologs
for LHX8 gene

Paralogs
for LHX8 gene

Genomic Variants
for LHX8 gene

Disorders / Diseases
for LHX8 gene

Publications
for LHX8 gene

Intellectual Property
for LHX8 gene

Products
for LHX8 gene