Aliases for LHX8 Gene
Aliases for LHX8 Gene
External Ids for LHX8 Gene
- HGNC: 28838
- Entrez Gene: 431707
- Ensembl: ENSG00000162624
- OMIM: 604425
- UniProtKB: Q68G74
Previous GeneCards Identifiers for LHX8 Gene
- GC01P075306
- GC01P075594
- GC01P073728
Summaries for LHX8 Gene
-
The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for LHX8 Gene
LHX8 (LIM Homeobox 8) is a Protein Coding gene. Diseases associated with LHX8 include Odontoma and Image Syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX4.
UniProtKB/Swiss-Prot for LHX8 Gene
-
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHX8 Gene
Genomics for LHX8 Gene
Regulatory Elements for LHX8 Gene
Enhancers for LHX8 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around LHX8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the LHX8 gene promoter:
Regulatory Element Products
Genomic Location for LHX8 Gene
- Chromosome:
- 1
- Start:
- 75,128,434 bp from pter
- End:
- 75,161,533 bp from pter
- Size:
- 33,100 bases
- Orientation:
- Plus strand
Genomic View for LHX8 Gene
Genes around LHX8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.1 by Ensembl
- 1p31.1 by Entrez Gene
- 1p31.1 by HGNC
LHX8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LHX8 Gene
Proteins for LHX8 Gene
-
Protein details for LHX8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q68G74-LHX8_HUMAN
- Recommended name:
- LIM/homeobox protein Lhx8
- Protein Accession:
- Q68G74
- E9PGE3
Protein attributes for LHX8 Gene
- Size:
- 356 amino acids
- Molecular mass:
- 39301 Da
- Quaternary structure:
- No Data Available
Protein Expression for LHX8 Gene
Post-translational modifications for LHX8 Gene
Other Protein References for LHX8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for LHX8
- Invitrogen Antibodies for LHX8
- antibodies-online Antibodies for LHX8: See all 46
- GeneTex LHX8 antibody for LHX8
-
Santa Cruz Biotechnology (SCBT) Antibodies for LHX8
Protein Products
-
OriGene Purified Proteins for LHX8
- Search Origene for MassSpec and Protein Over-expression Lysates for LHX8
- Origene Custom Protein Services for LHX8
- GeneTex LIM homeobox 8 Protein (GTX109165-pro) for LHX8
Assay Products
- antibodies-online Kits for LHX8: See all 19
No data available for DME Specific Peptides for LHX8 Gene
Domains & Families for LHX8 Gene
Gene Families for LHX8 Gene
Protein Domains for LHX8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LHX8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q68G74- Domain:
-
- Contains 1 homeobox DNA-binding domain.
- Contains 2 LIM zinc-binding domains.
Function for LHX8 Gene
Molecular function for LHX8 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for LHX8 Gene
- MGI mutant phenotypes for LHX8:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for LHX8:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for LHX8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LHX8 gene
- Search ViGene Biosciences for LHX8
CRISPR Products
-
OriGene CRISPR knockouts for LHX8
-
Santa Cruz Biotechnology (SCBT) CRISPR for LHX8
- GenScript: Design CRISPR guide RNA sequences for LHX8
miRNA Products
- Search ViGene Biosciences for LHX8
Clone Products
- OriGene clones in human for LHX8
- OriGene ORF clones in human,mouse,rat for LHX8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LHX8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
- ESI BIO PureStem 7PEND24, NCr-fac & Meso-prx Progenitor and PureStem 4D20.8, NCr-fac Progenitor for LHX8
-
ViGene Biosciences adenoviral particle packaged cDNA for LHX8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LHX8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LHX8 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LHX8 Gene
Localization for LHX8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LHX8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
No data available for Gene Ontology (GO) - Cellular Components for LHX8 Gene
Pathways & Interactions for LHX8 Gene
More details on SuperPathways for LHX8
No Data Available
Interacting Proteins for LHX8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0021879 | forebrain neuron differentiation | IEA | -- |
| GO:0021884 | forebrain neuron development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for LHX8 Gene
Transcripts for LHX8 Gene
mRNA/cDNA for LHX8 Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (9) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for LHX8
-
Santa Cruz Biotechnology (SCBT) CRISPR for LHX8
- GenScript: Design CRISPR guide RNA sequences for LHX8
miRNA Products
- Search ViGene Biosciences for LHX8
Clone Products
- OriGene clones in human for LHX8
- OriGene ORF clones in human,mouse,rat for LHX8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for LHX8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for LHX8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
- Thoracic Committed Brown Preadipocytes Thoracic Brown Adipose Depot
- Lumbar Committed Brown Preadipocytes Lumbar Brown Adipose Depot
- Cervical Brown Adipocyte Cells Cervical Brown Adipose Depot
- Thoracic Brown Adipocyte Cells Thoracic Brown Adipose Depot
-
Brain (Nervous System)
- Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
- Mature Endothelial Cells Blood Brain Barrier
- Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
- Endothelial Cells Blood Brain Barrier
- Cerebellum
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Myoblasts Mandibular Arch Muscles
- Muscle Progenitor Cells Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
-
Neural Tube (Nervous System)
- Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
- Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
- Telencephalon
- Diencephalon
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Dental Mesenchymal Cells Branchial Arch 1
- Dental Follicle Cells Dental Papilla
- Neural Crest (Gastrulation Derivatives)
- Bone (Muscoskeletal System)
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
- Cranial Neural Crest Cells Branchial Arch 1
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Ovary (Reproductive System)
- Gut Tube (Gastrointestinal Tract)
- Paraxial Mesoderm (Gastrulation Derivatives)
- NULL (Uncategorized)
- Cartilage (Muscoskeletal System)
- Germ Cells (Reproductive System)
- Gonad
mRNA differential expression in normal tissues according to GTEx for LHX8 Gene
This gene is overexpressed in Minor Salivary Gland (x14.3), Brain - Caudate (basal ganglia) (x9.1), Brain - Putamen (basal ganglia) (x7.3), Brain - Nucleus accumbens (basal ganglia) (x6.4), and Brain - Hypothalamus (x5.3).
This gene is overexpressed in Pancreatic juice (64.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LHX8 Gene
SOURCE GeneReport for Unigene cluster for LHX8 Gene Hs.403934
Primer Products
-
OriGene qPCR primer pairs for LHX8
No data available for mRNA Expression by UniProt/SwissProt for LHX8 Gene
Orthologs for LHX8 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | LHX8 35 |
|
||
| LHX8 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | LHX8 35 |
|
||
| LHX8 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Lhx8 35 |
|
||
| Lhx8 16 |
|
||||
| Lhx8 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | LHX8 35 |
|
||
| LHX8 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Lhx8 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | LHX8 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | LHX8 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LHX8 35 |
|
||
| LHX8 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | LHX8 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | lhx8 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | lhx8a 35 |
|
||
| lhx8a 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006540 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Awh 35 |
|
||
| Awh 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | lim-4 36 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PXL1 38 |
|
|
- Species with no ortholog for LHX8:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for LHX8 Gene
Paralogs for LHX8 Gene
(28) SIMAP similar genes for LHX8 Gene using alignment to 3 proteins:
Variants for LHX8 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs808470 | -- | 75,127,358(-) | ATACA(C/G)GAGGC | upstream-variant-2KB | |
| rs811598 | -- | 75,139,342(+) | AAACA(C/G)ACATT | intron-variant | |
| rs813834 | -- | 75,127,115(-) | GCCTA(G/T)AAAGG | upstream-variant-2KB | |
| rs814270 | -- | 75,127,234(-) | GGCCA(C/G)ACATT | upstream-variant-2KB | |
| rs729833 | -- | 75,135,460(-) | CGCGG(A/G)ACCCA | intron-variant |
Residual Variation Intolerance Score:
32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.11;
38.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for LHX8 Gene
- Human Gene Mutation Database (HGMD)
- LHX8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX8 Gene
Disorders for LHX8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| odontoma |
|
|
| image syndrome |
|
|
Search LHX8 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for LHX8
No data available for UniProtKB/Swiss-Prot and Genatlas for LHX8 Gene
Publications for LHX8 Gene
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48 67
- Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. (PMID: 9598319) Kitanaka J. … Wanaka A. (Genomics 1998) 2 3
- Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Upregulation of Lhx8 increase VAChT expression and ACh release in neuronal cell line SHSY5Y. (PMID: 24316404) Li H. … Qin J. (Neurosci. Lett. 2014) 3
Products for LHX8 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for LHX8
- Search Origene for MassSpec and Protein Over-expression Lysates for LHX8
- Origene Custom Protein Services for LHX8
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for LHX8
- Browse OriGene Inhibitory RNA Products For LHX8
- OriGene qPCR primer pairs for LHX8
- OriGene CRISPR knockouts for LHX8
- OriGene clones in human for LHX8
- OriGene ORF clones in human,mouse,rat for LHX8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for LHX8
- GenScript Custom Assay Services for LHX8
- GenScript Custom overexpressing Cell Line Services for LHX8
- GenScript: Design CRISPR guide RNA sequences for LHX8
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for LHX8
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor and PureStem 7PEND24, NCr-fac & Meso-prx Progenitor for LHX8
- antibodies-online Antibodies for LHX8: See all 46
- antibodies-online Kits for LHX8: See all 19
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex LHX8 antibody for LHX8
- GeneTex LIM homeobox 8 Protein (GTX109165-pro) for LHX8
- ViGene Biosciences adenoviral particle packaged cDNA for LHX8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for LHX8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for LHX8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for LHX8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for LHX8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for LHX8 gene
- Search ViGene Biosciences for LHX8
- Search ViGene Biosciences for LHX8
- Santa Cruz Biotechnology (SCBT) Antibodies for LHX8
- Search Santa Cruz Biotechnology (SCBT) for LHX8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for LHX8
Sources for LHX8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon