Aliases for LHX8 Gene
Aliases for LHX8 Gene
External Ids for LHX8 Gene
- HGNC: 28838
- Entrez Gene: 431707
- Ensembl: ENSG00000162624
- OMIM: 604425
- UniProtKB: Q68G74
Previous GeneCards Identifiers for LHX8 Gene
- GC01P075306
- GC01P075594
- GC01P073728
Summaries for LHX8 Gene
-
The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for LHX8 Gene
LHX8 (LIM Homeobox 8) is a Protein Coding gene. Diseases associated with LHX8 include Odontoma and Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX6.
UniProtKB/Swiss-Prot for LHX8 Gene
-
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHX8 Gene
Genomics for LHX8 Gene
GeneHancer (GH) Regulatory Elements for LHX8 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01I075137 | Promoter | 0.9 | EPDnew | 550.4 | +7.9 | 7935 | 0.1 | PKNOX1 ZBTB6 ZNF189 ZNF223 SIN3A ZBTB8A ZNF335 CTBP2 ZBTB26 ZBTB17 | LHX8 ENSG00000224127 GC01M075131 | |
GH01I075128 | Promoter | 0.7 | EPDnew | 550.8 | +0.0 | 2 | 0.1 | CTCF EZH2 | LHX8 ENSG00000224127 ENSG00000224149 | |
GH01I075134 | Promoter | 0.7 | EPDnew | 550.4 | +6.4 | 6432 | 0.1 | L3MBTL2 SUZ12 EZH2 | ENSG00000224127 LHX8 GC01M075131 | |
GH01I075125 | Enhancer | 0.5 | FANTOM5 | 0.8 | -3.1 | -3149 | 0.4 | AFF1 L3MBTL2 MGA | ENSG00000261213 SLC44A5 LHX8 | |
GH01I075136 | Enhancer | 0.6 | ENCODE | 0.4 | +8.2 | 8217 | 0.2 | L3MBTL2 ZNF189 SIN3A ZBTB8A CTBP2 ZBTB26 EZH2 ZBTB20 | SLC44A5 ENSG00000224127 GC01M075131 LHX8 |
- Top Transcription factor binding sites by QIAGEN in the LHX8 gene promoter:
Regulatory Element Products
Genomic Locations for LHX8 Gene
- chr1:75,128,434-75,161,533
- (GRCh38/hg38)
- Size:
- 33,100 bases
- Orientation:
- Plus strand
- chr1:75,594,119-75,627,218
- (GRCh37/hg19)
Genomic View for LHX8 Gene
- Cytogenetic band:
-
- 1p31.1 by Ensembl
- 1p31.1 by Entrez Gene
- 1p31.1 by HGNC


RefSeq DNA sequence for LHX8 Gene
Proteins for LHX8 Gene
-
Protein details for LHX8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q68G74-LHX8_HUMAN
- Recommended name:
- LIM/homeobox protein Lhx8
- Protein Accession:
- Q68G74
- E9PGE3
Protein attributes for LHX8 Gene
- Size:
- 356 amino acids
- Molecular mass:
- 39301 Da
- Quaternary structure:
- No Data Available
Protein Expression for LHX8 Gene
Post-translational modifications for LHX8 Gene
Other Protein References for LHX8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
-
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- antibodies-online: Search results for 2 available LHX8 Proteins ranked by validation data
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-
Quality Products:
- GeneTex Proteins for LHX8
Assay Products
No data available for DME Specific Peptides for LHX8 Gene
Domains & Families for LHX8 Gene
Gene Families for LHX8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for LHX8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for LHX8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for LHX8 Gene
Function for LHX8 Gene
Molecular function for LHX8 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
Phenotypes From GWAS Catalog for LHX8 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0043565 | sequence-specific DNA binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for LHX8 Gene
- MGI mutant phenotypes for LHX8:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for LHX8:
Animal Model Products
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-
-
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-
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- Search ViGene Biosciences for LHX8
CRISPR Products
-
OriGene CRISPR knockouts for LHX8
- genomics-online: gRNA clones - Search results for 109 available LHX8 gene related products
- Overview of 109 available LHX8 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LHX8
- GenScript: Design CRISPR guide RNA sequences for LHX8
miRNA Products
- Search ViGene Biosciences for LHX8
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LHX8
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- genomics-online: shRNA clones - Search results for 109 available LHX8 gene related products
- Overview of 109 available LHX8 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LHX8 gene
Clone Products
- Sino Biological Human cDNA Clone for LHX8
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- VectorBuilder custom plasmid, inducible vectors for LHX8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LHX8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LHX8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor and PureStem 7PEND24, NCr-fac & Meso-prx Progenitor for LHX8
-
Horizon Cell Lines for LHX8
-
ViGene Biosciences adenoviral particle packaged cDNA for LHX8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LHX8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LHX8 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LHX8 Gene
Localization for LHX8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for LHX8 Gene
- Nucleus.
- Cytosol (2)
- Nucleoli (2)
- Nucleus (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001674 | female germ cell nucleus | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for LHX8 Gene
Interacting Proteins for LHX8 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007611 | learning or memory | IEA | -- |
GO:0008585 | female gonad development | IEA | -- |
GO:0021879 | forebrain neuron differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for LHX8 Gene
Transcripts for LHX8 Gene
mRNA/cDNA for LHX8 Gene
- (4) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (9) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for LHX8
- genomics-online: gRNA clones - Search results for 109 available LHX8 gene related products
- Overview of 109 available LHX8 gene related products
- Applied Biological Materials CRISPR for LHX8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LHX8
- GenScript: Design CRISPR guide RNA sequences for LHX8
miRNA Products
- Search ViGene Biosciences for LHX8
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LHX8
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- genomics-online: shRNA clones - Search results for 109 available LHX8 gene related products
- Overview of 109 available LHX8 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LHX8 gene
Clone Products
- Sino Biological Human cDNA Clone for LHX8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for LHX8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LHX8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for LHX8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LHX8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
- Thoracic Committed Brown Preadipocytes Thoracic Brown Adipose Depot
- Lumbar Committed Brown Preadipocytes Lumbar Brown Adipose Depot
- Cervical Brown Adipocyte Cells Cervical Brown Adipose Depot
- Thoracic Brown Adipocyte Cells Thoracic Brown Adipose Depot
-
Brain (Nervous System)
- Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
- Mature Endothelial Cells Blood Brain Barrier
- Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
- Endothelial Cells Blood Brain Barrier
- Cerebellum
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Myoblasts Mandibular Arch Muscles
- Muscle Progenitor Cells Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
-
Neural Tube (Nervous System)
- Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
- Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
- Telencephalon
- Diencephalon
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Dental Mesenchymal Cells Branchial Arch 1
- Dental Follicle Cells Dental Papilla
- Neural Crest (Gastrulation Derivatives)
- Bone (Muscoskeletal System)
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
- Cranial Neural Crest Cells Branchial Arch 1
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Ovary (Reproductive System)
- Gut Tube (Gastrointestinal Tract)
- Paraxial Mesoderm (Gastrulation Derivatives)
- NULL (Uncategorized)
- Cartilage (Muscoskeletal System)
- Germ Cells (Reproductive System)
- Gonad
mRNA differential expression in normal tissues according to GTEx for LHX8 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LHX8 Gene
NURSA nuclear receptor signaling pathways regulating expression of LHX8 Gene:
LHX8SOURCE GeneReport for Unigene cluster for LHX8 Gene:
Hs.403934Primer Products
-
OriGene qPCR primer pairs for LHX8
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LHX8 Gene
Orthologs for LHX8 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LHX8 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | LHX8 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | LHX8 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Lhx8 33 |
|
||
mouse (Mus musculus) |
Mammalia | Lhx8 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | LHX8 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | LHX8 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | LHX8 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | LHX8 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | lhx8 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | lhx8a 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006540 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Awh 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | lim-4 34 |
|
OneToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PXL1 36 |
|
|
- Species where no ortholog for LHX8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for LHX8 Gene
Paralogs for LHX8 Gene
(28) SIMAP similar genes for LHX8 Gene using alignment to 3 proteins:
Variants for LHX8 Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000027947 | -- | 75,145,546(+) | A/T | intron_variant | |
rs1000178763 | -- | 75,138,678(+) | A/G | intron_variant | |
rs1000191102 | -- | 75,129,771(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
rs1000193912 | -- | 75,182,625(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000251056 | -- | 75,138,345(+) | T/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2632878 | CNV | deletion | 19546169 |
nsv1078876 | OTHER | inversion | 25765185 |
nsv1444 | CNV | insertion | 18451855 |
Additional Variant Information for LHX8 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX8 Gene
Disorders for LHX8 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
odontoma |
|
|
intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies |
|
|
cleft palate, isolated |
|
|
cleft lip/palate |
|
|
premature ovarian failure 1 |
|
|
Additional Disease Information for LHX8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for LHX8 Gene
Publications for LHX8 Gene
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
- Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PMID: 20672350) Nikopensius T … Metspalu A (Birth defects research. Part A, Clinical and molecular teratology 2010) 3 44 58
- MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PMID: 20572854) Jagomägi T … Metspalu A (European journal of oral sciences 2010) 3 44 58
- Analysis of LHX8 mutation in premature ovarian failure. (PMID: 17624344) Qin Y … Rajkovic A (Fertility and sterility 2008) 3 44 58
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58
Products for LHX8 Gene
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- ESI BIO PureStem 4D20.8, NCr-fac Progenitor and PureStem 7PEND24, NCr-fac & Meso-prx Progenitor for LHX8
- Invitrogen Antibodies for LHX8
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- VectorBuilder custom plasmid, inducible vectors for LHX8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LHX8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 46 available LHX8 Antibodies ranked by validation data
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- Overview of 109 available LHX8 gene related products
Sources for LHX8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
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