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Aliases for LHX8 Gene

Aliases for LHX8 Gene

  • LIM Homeobox 8 2 3 5
  • LIM-Homeodomain Protein Lhx8 3
  • LIM Homeobox Protein 8 4
  • LHX7 3

External Ids for LHX8 Gene

Previous GeneCards Identifiers for LHX8 Gene

  • GC01P075306
  • GC01P075594
  • GC01P073728

Summaries for LHX8 Gene

Entrez Gene Summary for LHX8 Gene

  • The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for LHX8 Gene

LHX8 (LIM Homeobox 8) is a Protein Coding gene. Diseases associated with LHX8 include odontoma and image syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX4.

UniProtKB/Swiss-Prot for LHX8 Gene

  • Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHX8 Gene

Genomics for LHX8 Gene

Regulatory Elements for LHX8 Gene

Enhancers for LHX8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LHX8 on UCSC Golden Path with GeneCards custom track

Genomic Location for LHX8 Gene

Chromosome:
1
Start:
75,128,434 bp from pter
End:
75,161,533 bp from pter
Size:
33,100 bases
Orientation:
Plus strand

Genomic View for LHX8 Gene

Genes around LHX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHX8 Gene

Proteins for LHX8 Gene

  • Protein details for LHX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68G74-LHX8_HUMAN
    Recommended name:
    LIM/homeobox protein Lhx8
    Protein Accession:
    Q68G74
    Secondary Accessions:
    • E9PGE3

    Protein attributes for LHX8 Gene

    Size:
    356 amino acids
    Molecular mass:
    39301 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LHX8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LHX8 Gene

Proteomics data for LHX8 Gene at MOPED

Post-translational modifications for LHX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHX8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LHX8 Gene

Domains & Families for LHX8 Gene

Gene Families for LHX8 Gene

Protein Domains for LHX8 Gene

Suggested Antigen Peptide Sequences for LHX8 Gene

Graphical View of Domain Structure for InterPro Entry

Q68G74

UniProtKB/Swiss-Prot:

LHX8_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with LHX8: view

Function for LHX8 Gene

Molecular function for LHX8 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Gene Ontology (GO) - Molecular Function for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with LHX8: view
genes like me logo Genes that share phenotypes with LHX8: view

Animal Models for LHX8 Gene

MGI Knock Outs for LHX8:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LHX8 Gene

Localization for LHX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHX8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LHX8 Gene COMPARTMENTS Subcellular localization image for LHX8 gene
Compartment Confidence
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for LHX8 Gene

Pathways & Interactions for LHX8 Gene

SuperPathways for LHX8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0021879 forebrain neuron differentiation IEA --
GO:0021884 forebrain neuron development IEA --
genes like me logo Genes that share ontologies with LHX8: view

No data available for Pathways by source and SIGNOR curated interactions for LHX8 Gene

Drugs & Compounds for LHX8 Gene

No Compound Related Data Available

Transcripts for LHX8 Gene

mRNA/cDNA for LHX8 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LHX8 Gene

LIM homeobox 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LHX8 Gene

No ASD Table

Relevant External Links for LHX8 Gene

GeneLoc Exon Structure for
LHX8
ECgene alternative splicing isoforms for
LHX8

Expression for LHX8 Gene

mRNA expression in normal human tissues for LHX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHX8 Gene

This gene is overexpressed in Minor Salivary Gland (x14.3), Brain - Caudate (basal ganglia) (x9.1), Brain - Putamen (basal ganglia) (x7.3), Brain - Nucleus accumbens (basal ganglia) (x6.4), and Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for LHX8 Gene

This gene is overexpressed in Pancreatic juice (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LHX8 Gene



SOURCE GeneReport for Unigene cluster for LHX8 Gene Hs.403934

genes like me logo Genes that share expression patterns with LHX8: view

Protein tissue co-expression partners for LHX8 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LHX8 Gene

Orthologs for LHX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LHX8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LHX8 35
  • 95.38 (n)
  • 98.55 (a)
LHX8 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LHX8 35
  • 95.22 (n)
  • 99.07 (a)
LHX8 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lhx8 35
  • 87.91 (n)
  • 96.65 (a)
Lhx8 16
Lhx8 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LHX8 35
  • 99.63 (n)
  • 100 (a)
LHX8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lhx8 35
  • 88.13 (n)
  • 97.21 (a)
oppossum
(Monodelphis domestica)
Mammalia LHX8 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LHX8 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves LHX8 35
  • 87.07 (n)
  • 95.89 (a)
LHX8 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LHX8 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lhx8 35
  • 75.46 (n)
  • 85.22 (a)
zebrafish
(Danio rerio)
Actinopterygii lhx8a 35
  • 71.48 (n)
  • 82.56 (a)
lhx8a 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006540 35
  • 53.5 (n)
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Awh 35
  • 50.59 (n)
  • 47.79 (a)
Awh 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lim-4 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PXL1 38
Species with no ortholog for LHX8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHX8 Gene

ENSEMBL:
Gene Tree for LHX8 (if available)
TreeFam:
Gene Tree for LHX8 (if available)

Paralogs for LHX8 Gene

Paralogs for LHX8 Gene

genes like me logo Genes that share paralogs with LHX8: view

Variants for LHX8 Gene

Sequence variations from dbSNP and Humsavar for LHX8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs808470 -- 75,127,358(-) ATACA(C/G)GAGGC upstream-variant-2KB
rs811598 -- 75,139,342(+) AAACA(C/G)ACATT intron-variant
rs813834 -- 75,127,115(-) GCCTA(G/T)AAAGG upstream-variant-2KB
rs814270 -- 75,127,234(-) GGCCA(C/G)ACATT upstream-variant-2KB
rs729833 -- 75,135,460(-) CGCGG(A/G)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHX8 Gene

Variant ID Type Subtype PubMed ID
nsv871743 CNV Gain 21882294
nsv1444 CNV Insertion 18451855
esv2632878 CNV Deletion 19546169

Variation tolerance for LHX8 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LHX8 Gene

HapMap Linkage Disequilibrium report
LHX8
Human Gene Mutation Database (HGMD)
LHX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX8 Gene

Disorders for LHX8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LHX8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
odontoma
image syndrome
  • intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, genital abnormalities
- elite association - COSMIC cancer census association via MalaCards
Search LHX8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LHX8

Genetic Association Database (GAD)
LHX8
Human Genome Epidemiology (HuGE) Navigator
LHX8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LHX8
genes like me logo Genes that share disorders with LHX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHX8 Gene

Publications for LHX8 Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48 67
  2. Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. (PMID: 9598319) Kitanaka J. … Wanaka A. (Genomics 1998) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Upregulation of Lhx8 increase VAChT expression and ACh release in neuronal cell line SHSY5Y. (PMID: 24316404) Li H. … Qin J. (Neurosci. Lett. 2014) 3

Products for LHX8 Gene

Sources for LHX8 Gene

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