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LHX8 Gene

protein-coding   GIFtS: 51
GCID: GC01P075594

LIM Homeobox 8

  See LHX8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Homeobox 81 2
LHX72
LIM-Homeodomain Protein Lhx82
LIM/Homeobox Protein Lhx82
LIM Homeobox Protein 83

External Ids:    HGNC: 288381   Entrez Gene: 4317072   Ensembl: ENSG000001626247   OMIM: 6044255   UniProtKB: Q68G743   

Export aliases for LHX8 gene to outside databases

Previous GC identifers: GC01P075306 GC01P073728


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LHX8 Gene:
The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in
patterning and differentiation of various tissue types. These proteins contain two tandemly repeated
cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This
family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in
oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also
associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants.
(provided by RefSeq, Jan 2012)

GeneCards Summary for LHX8 Gene:
LHX8 (LIM homeobox 8) is a protein-coding gene. Diseases associated with LHX8 include odontoma, and cleft palate. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74
Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the LHX8 gene promoter:
         HNF-4alpha2   Nkx2-5   CUTL1   YY1   Egr-4   HNF-4alpha1   AREB6   PPAR-gamma1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX8 promoter sequence
   Search Chromatin IP Primers for LHX8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHX8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

LHX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P075594:  view genomic region     (about GC identifiers)

Start:
75,594,119 bp from pter      End:
75,627,218 bp from pter
Size:
33,100 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx8  
Size: 356 amino acids; 39301 Da
Secondary accessions: E9PGE3
Alternative splicing: 2 isoforms:  Q68G74-1   Q68G74-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for LHX8: NX_Q68G74

Explore proteomics data for LHX8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LHX8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001933.1  NP_001243043.1  

    ENSEMBL proteins: 
     ENSP00000294638   ENSP00000348597  

    LHX8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LHX8

     
    Search eBioscience for Proteins for LHX8 

    LHX8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for LHX8 at Abcam
    Cloud-Clone Corp. Antibodies for LHX8
    ThermoFisher Antibodies for LHX8
    LSBio Antibodies in human, mouse, rat for LHX8

    LHX8 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LHX8
    Cloud-Clone Corp. CLIAs for LHX8
    Search eBioscience for ELISAs for LHX8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q68G74

    ProtoNet protein and cluster: Q68G74

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LHX8_HUMAN, Q68G74
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with LHX8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LHX8_HUMAN, Q68G74
    Function: Transcription factor involved in differentiation of certain neurons and mesenchymal cells (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with LHX8           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lhx8):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  growth/size/body 
     mortality/aging  nervous system 

    Find genes that share phenotypes with LHX8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lhx8tm1Lmgd for LHX8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LHX8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LHX8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHX8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHX8

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LHX8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LHX8 (see all 46):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidLHX8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LHX8
    Predesigned siRNA for gene silencing in human, mouse, rat LHX8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LHX8

    Clone
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    OriGene clones in human, mouse for LHX8 (see all 6)
    OriGene ORF clones in mouse, rat for LHX8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
    Sino Biological Human cDNA Clone for LHX8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LHX8
    ESI BIO PureStem Progenitors for LHX8: 
    PureStem 4D20.8, NCr-fac Progenitor, PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LHX8_HUMAN, Q68G74: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with LHX8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LHX8
    Interactions:

        Search GeneGlobe Interaction Network for LHX8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for LHX8 (ENSP000002946384) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LHX9ENSP000003563574STRING: ENSP00000356357
    LDB1ENSP000003924664STRING: ENSP00000392466
    LDB2ENSP000003067724STRING: ENSP00000306772
    LHX3ENSP000003608114STRING: ENSP00000360811
    LHX4ENSP000002637264STRING: ENSP00000263726
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007611learning or memory IEA--
    GO:0008585female gonad development IEA--
    GO:0021879forebrain neuron differentiation ----

    Find genes that share ontologies with LHX8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LHX8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LHX8 gene (2 alternative transcripts): 
    NM_001001933.1  NM_001256114.1  

    Unigene Cluster for LHX8:

    LIM homeobox 8
    Hs.403934  [show with all ESTs]
    Unigene Representative Sequence: BC040321
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294638(uc021oou.1 uc001dgo.3) ENST00000356261(uc001dgq.3)
    ENST00000559413 ENST00000607240
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LHX8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LHX8 (see all 46):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-106a hsa-miR-30d hsa-miR-507 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidLHX8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LHX8
    Predesigned siRNA for gene silencing in human, mouse, rat LHX8
    Clone
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    OriGene clones in human, mouse for LHX8 (see all 6)
    OriGene ORF clones in mouse, rat for LHX8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LHX8 (NM_001001933)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX8
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LHX8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX8
      QuantiTect SYBR Green Assays in human, mouse, rat LHX8
      QuantiFast Probe-based Assays in human, mouse, rat LHX8

    Additional mRNA sequence: 

    BC036423.1 BC040321.1 

    3 DOTS entries:

    DT.95088275  DT.92020528  DT.95222210 

    9 AceView cDNA sequences:

    BC040321 NM_001001933 BF978460 BC036423 BG772403 AK094667 BG709099 BF572867 
    AA331573 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LHX8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAACACATT
    LHX8 Expression
    About this image


    LHX8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 8 entries
             Sacral Brown Adipocyte Cells Sacral Brown Adipose Depot
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
             Cerebellum
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             Cranial Neural Crest Cells Branchial Arch 1
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian tissue-dissociated cells (human)
             Oocytes
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
             Telencephalon
    LHX8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LHX8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.403934
        Custom PCR Arrays for LHX8
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LHX8 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhx81 , 5 LIM homeobox protein 81, 5 87.91(n)1
    96.65(a)1
      3 (79.12 cM)5
    168751  NM_010713.21  NP_034843.21 
     1543062885 
    chicken
    (Gallus gallus)
    Aves LHX81 LIM homeobox 8 87.07(n)
    95.89(a)
      424721  NM_001040466.2  NP_001035556.1 
    lizard
    (Anolis carolinensis)
    Reptilia LHX86
    LIM homeobox 8
    84(a)
    1 ↔ 1
    GL343194.1(2994192-3019747)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lhx81 LIM homeobox 8 75.46(n)
    85.22(a)
      548653  NM_001015899.1  NP_001015899.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lhx8a1 LIM homeobox 8a 71.48(n)
    82.56(a)
      378959  NM_001003980.2  NP_001003980.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Awh1 Arrowhead 50.59(n)
    47.79(a)
      38451  NM_168042.2  NP_728906.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lim-46
    Protein LIM-4 (lim-4) mRNA, complete cds
    32(a)
    1 → many
    X(3869753-3873295) WBGene00002987


    ENSEMBL Gene Tree for LHX8 (if available)
    TreeFam Gene Tree for LHX8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LHX8 gene
    ISL12  LHX22  LHX92  LMX1B2  LHX52  LHX62  LHX12  LMX1A2  
    LHX42  LHX32  ISL22  
    Selected SIMAP similar genes for LHX8 using alignment to 3 protein entries:     LHX8_HUMAN (see all proteins) (see all similar genes):
    Lhx8    LHX6    LHX4    LIMD1    LHX1    LHX3
    LHx4    TES    LMO3    LMO4    POU6F1    LMO1
    ISL2    WTIP    ZYX    LMX1B    LHX9    LPP

    Find genes that share paralogs with LHX8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LHX8 (see all 648)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447284191,2
    Cuntested175622667(+) CCCTCC/TAGGCT 4 S syn11Minor allele frequency- T:0.00NA 4552
    rs170962891,2
    C,F,H--75592165(+) CTGCCG/ACCTAT 1 -- us2k117Minor allele frequency- A:0.36NA NS EA WA CSA 934
    rs104935521,2
    C,F,A,H--75592228(+) AAGAGC/ATTAGC 1 -- us2k117Minor allele frequency- A:0.40NS NA EA WA 1026
    rs1421244521,2
    --75592391(+) TTTGCC/TGTGTT 1 -- us2k10--------
    rs359544321,2
    F--75592726(+) AGACTC/TCATCT 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs8138341,2
    C,H--75592800(-) GCCTAG/TAAAGG 1 -- us2k1 trp36Minor allele frequency- T:0.00NS EA NA 424
    rs1901226771,2
    --75592896(+) TGAAGC/GAAGCC 1 -- us2k10--------
    rs8142701,2
    H--75592919(-) GGCCAG/CACATT 1 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs758409631,2
    F--75592932(+) CACACA/GCAGCA 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs8084701,2
    H--75593043(-) ATACAG/CGAGGC 1 -- us2k14Minor allele frequency- C:0.00NS EA 420

    HapMap Linkage Disequilibrium report for LHX8 (75594119 - 75627218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LHX8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2632878CNV Deletion19546169
    nsv1444CNV Insertion18451855
    nsv871743CNV Gain21882294

    Human Gene Mutation Database (HGMD): LHX8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LHX8
    DNA2.0 Custom Variant and Variant Library Synthesis for LHX8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604425    OMIM disorders: --

    2 diseases for LHX8:    
    About MalaCards
    odontoma    cleft palate

    2 diseases from the University of Copenhagen DISEASES database for LHX8:
    Cleft palate     Premature ovarian failure

    Find genes that share disorders with LHX8           About GenesLikeMe

    Genetic Association Database (GAD): LHX8
    Human Genome Epidemiology (HuGE) Navigator: LHX8 (6 documents)

    Export disorders for LHX8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LHX8 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with LHX8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    2. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    3. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (Eur. J. Oral Sci. 2010)
    4. Analysis of LHX8 mutation in premature ovarian failure. (PubMed id 17624344)1, 4 Qin Y....Rajkovic A. (Fertil. Steril. 2008)
    5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    6. Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)1, 4 Vieira A.R.... Murray J.C. (PLoS Genet. 2005)
    7. Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. (PubMed id 9598319)1, 3 Kitanaka J....Wanaka A. (Genomics 1998)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. (PubMed id 22435649)1 Paschou P....Grigoriou M. (Genes Brain Behav. 2012)
    10. Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development. (PubMed id 22204396)1 Nat R....Dechant G. (Stem Cells Dev. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 431707 HGNC: 28838 AceView: LHX8 Ensembl:ENSG00000162624 euGenes: HUgn431707
    ECgene: LHX8 H-InvDB: LHX8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LHX8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LHX8 gene:
    Search GeneIP for patents involving LHX8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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