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LHX6 Gene

protein-coding   GIFtS: 52
GCID: GC09M124964

LIM Homeobox 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Homeobox 61 2
LHX6.12 3
LIM/Homeobox Protein Lhx6.12 3
LIM Homeodomain Protein 6.12
LIM/Homeobox Protein Lhx62
LIM Homeobox Protein 63

External Ids:    HGNC: 217351   Entrez Gene: 264682   Ensembl: ENSG000001068527   OMIM: 6082155   UniProtKB: Q9UPM63   

Export aliases for LHX6 gene to outside databases

Previous GC identifers: GC09M116069 GC09M116611 GC09M118418 GC09M120340 GC09M122044 GC09M124004 GC09M094579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LHX6 Gene:
This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich
zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the
control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript
variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants
have been identified, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for LHX6 Gene:
LHX6 (LIM homeobox 6) is a protein-coding gene. Diseases associated with LHX6 include cervix uteri carcinoma in situ, and cervical cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX6_HUMAN, Q9UPM6
Function: Probable transcription factor required for the expression of a subset of genes involved in interneurons
migration and development. Functions in the specification of cortical interneuron subtypes and in the migration
of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity)

Gene Wiki entry for LHX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LHX6 gene promoter:
         NF-1   NF-1/L   Sox5   STAT2   STAT3   IRF-7A   CUTL1   HNF-3beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX6 promoter sequence
   Search Chromatin IP Primers for LHX6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33.2

LHX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M124964:  view genomic region     (about GC identifiers)

Start:
124,964,856 bp from pter      End:
124,991,905 bp from pter
Size:
27,050 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LHX6_HUMAN, Q9UPM6 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx6  
Size: 363 amino acids; 40045 Da
Subunit: Interacts with LDB1 (via the LIM zinc-binding domains) (By similarity)
Sequence caution: Sequence=AAI03937.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI03938.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB66505.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6PVQ1 A6PVQ2 A8K1B2 B7Z4D0 H0YN76 Q5T7S7 Q5T7S8 Q9NTK3 Q9UPM5
Alternative splicing: 6 isoforms:  Q9UPM6-1   Q9UPM6-2   Q9UPM6-3   Q9UPM6-4   Q9UPM6-5   Q9UPM6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LHX6: NX_Q9UPM6

Explore proteomics data for LHX6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LHX6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001229262.1  NP_001229263.1  NP_001229264.1  NP_055183.2  NP_954629.2  

    ENSEMBL proteins: 
     ENSP00000362860   ENSP00000362859   ENSP00000340137   ENSP00000377854   ENSP00000475927  
     ENSP00000441464   ENSP00000452811   ENSP00000453798   ENSP00000453606  

    LHX6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UPM6

    ProtoNet protein and cluster: Q9UPM6

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LHX6_HUMAN, Q9UPM6
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    LHX6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LHX6_HUMAN, Q9UPM6
    Function: Probable transcription factor required for the expression of a subset of genes involved in interneurons
    migration and development. Functions in the specification of cortical interneuron subtypes and in the migration
    of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10393337
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    LHX6 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lhx6):
     behavior/neurological  cellular  mortality/aging  nervous system  no phenotypic analysis 
     normal 

    LHX6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lhx6tm2Vpa for LHX6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LHX6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LHX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHX6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHX6

    miRNA
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    miRTarBase miRNAs that target LHX6:
    hsa-mir-26b-5p (MIRT028799), hsa-mir-335-5p (MIRT016904)

    Block miRNA regulation of human, mouse, rat LHX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LHX6 (see all 104):
    hsa-miR-411* hsa-miR-100* hsa-miR-3194-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-218-1* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidLHX6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LHX6

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    GenScript: all cDNA clones in your preferred vector (see all 2): LHX6 (NM_014368)
    Sino Biological Human cDNA Clone for LHX6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LHX6_HUMAN, Q9UPM6: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    LHX6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LHX6
    Interactions:

        Search GeneGlobe Interaction Network for LHX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for LHX6 (ENSP000003778544) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LHX9ENSP000003563574STRING: ENSP00000356357
    LDB1ENSP000003924664STRING: ENSP00000392466
    LDB2ENSP000003067724STRING: ENSP00000306772
    LHX3ENSP000003608114STRING: ENSP00000360811
    LHX4ENSP000002637264STRING: ENSP00000263726
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0021799cerebral cortex radially oriented cell migration ISS--
    GO:0021800cerebral cortex tangential migration ISS--
    GO:0021853cerebral cortex GABAergic interneuron migration ISS--

    LHX6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LHX6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LHX6 gene (5 alternative transcripts): 
    NM_001242333.1  NM_001242334.1  NM_001242335.1  NM_014368.4  NM_199160.3  

    Unigene Cluster for LHX6:

    LIM homeobox 6
    Hs.103137  [show with all ESTs]
    Unigene Representative Sequence: NM_001242335
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373755(uc010mvw.3) ENST00000373754(uc022bmx.1) ENST00000340587(uc004bly.4)
    ENST00000394319(uc004blx.4) ENST00000559895(uc022bmw.1) ENST00000541397
    ENST00000464484 ENST00000482062 ENST00000558672 ENST00000560152 ENST00000560485
    ENST00000559529
    miRNA
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    Block miRNA regulation of human, mouse, rat LHX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LHX6 (see all 104):
    hsa-miR-411* hsa-miR-100* hsa-miR-3194-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-218-1* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidLHX6 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for LHX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LHX6 (NM_014368)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LHX6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX6
      QuantiTect SYBR Green Assays in human, mouse, rat LHX6
      QuantiFast Probe-based Assays in human, mouse, rat LHX6

    Additional mRNA sequence: 

    AB031041.1 AB031042.1 AK126982.1 AK289827.1 AK297175.1 AK299709.1 AK313808.1 AL136570.1 
    BC103936.1 BC103937.1 BC103938.1 

    10 DOTS entries:

    DT.412600  DT.97811234  DT.99992081  DT.121209120  DT.121209122  DT.40262865  DT.95364250  DT.121209119 
    DT.121209123  DT.121209172 

    Selected AceView cDNA sequences (see all 50):

    AK126982 BQ003604 NM_199160 BU540587 BX089771 W61009 AA136365 AI186377 
    AI265821 AA128312 NM_014368 AL136570 AW662166 AW629363 AI279977 BM450588 
    BV200799 BE280401 AB031042 BI251909 BQ575483 BI913711 BM826954 BM048794 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LHX6 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c · 14d
    SP1:                                -           -           -     -                       -                       -     -                                       
    SP2:                                -           -           -     -                       -                       -     -           -                           
    SP3:                                                              -                       -                       -     -                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for LHX6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LHX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGTGCTTTG
    LHX6 Expression
    About this image


    LHX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
             Cerebellum
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 1
     
     Neural Crest (Gastrulation Derivatives)
             Cranial Neural Crest Cells Branchial Arch 1
     
     Tooth
             Dental Follicle Cells Dental Papilla
    LHX6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LHX6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.103137
        Custom PCR Arrays for LHX6
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LHX6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhx61 , 5 LIM homeobox protein 61, 5 92.35(n)1
    97.96(a)1
      2 (24.17 cM)5
    168741  NM_008500.21  NP_032526.21 
     360819505 
    chicken
    (Gallus gallus)
    Aves LHX61 LIM homeobox 6 73.67(n)
    77.36(a)
      772259  XM_001235420.3  XP_001235421.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lhx61 LIM homeobox 6 71.89(n)
    82.52(a)
      100493242  XM_002941138.2  XP_002941184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lhx61 LIM homeobox 6 72.84(n)
    79.37(a)
      445565  NM_001004015.2  NP_001004015.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Awh3 transcription factor 48(a)   63F4   --
    worm
    (Caenorhabditis elegans)
    Secernentea lim-43 LIM-homeodomain 44(a)   X(3905023-3905852)   --


    ENSEMBL Gene Tree for LHX6 (if available)
    TreeFam Gene Tree for LHX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LHX6 gene
    ISL12  LHX22  LHX92  LMX1B2  LHX52  LHX12  LMX1A2  LHX42  
    LHX32  LHX82  ISL22  
    14 SIMAP similar genes for LHX6 using alignment to 5 protein entries:     LHX6_HUMAN (see all proteins):
    LHX8    LHX4    Lhx8    LHx4    LMO1    LHX3
    LMO4    LHX1    LMO3    POU6F1    ISL1    ISL2
    LMO2    LHX9

    LHX6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LHX6 (see all 489)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134028241,2
    C,F--124970985(+) GTAGGT/CGCCTG 5 -- int11Minor allele frequency- C:0.00CSA 1
    rs343554041,2
    C--124971114(+) TGTCT-/AAAAAA 5 -- int11Minor allele frequency- A:0.50NA 2
    rs604281821,2
    C--124974376(+) TACTT-/TATGCG 5 -- int10--------
    rs802760471,2
    C,F--124976235(+) CCCCAC/TCCTCT 5 -- int11Minor allele frequency- T:0.09WA 118
    rs1860596311,2
    --124976267(+) TCTCAC/TCTGAT 5 -- int10--------
    rs1897811541,2
    --124976335(+) CTCCTC/TCAGGA 5 -- int10--------
    rs735533561,2
    C,F--124976343(+) GGACAA/GGGTCT 5 -- int13Minor allele frequency- G:0.15WA CSA 122
    rs1394623911,2
    --124976573(+) TACACC/TGTCCA 5 -- int10--------
    rs1812193561,2
    --124976610(+) GACCTA/TAGCCC 5 -- int10--------
    rs794573161,2
    --124976733(+) TGAAAG/TGTATG 5 -- ut311Minor allele frequency- T:0.01EA 120
    rs1869211831,2
    --124976842(+) GGCCTC/GTACGT 5 -- ut310--------
    rs1905681821,2
    --124976856(+) CAGGCC/TGCTCT 5 -- ut310--------
    rs1442116621,2
    --124977213(+) GTCTTC/TGGAAG 5 -- ut310--------
    rs753744211,2
    C,F--124977231(+) AAGCAG/TGTTCC 5 -- ut311Minor allele frequency- T:0.02EA 120
    rs1460876821,2
    C--124977248(+) AGGCTA/GCACCT 5 -- ut310--------
    rs1398087181,2
    --124977490(+) CACAGC/TAGGAA 5 -- ut310--------
    rs109855631,2
    C,F,H--124977498(+) GAAGGC/TGGACT 5 -- ut3117Minor allele frequency- T:0.42NS EA NA WA 2340
    rs1161266391,2
    C,F--124977499(+) AAGGCG/AGACTT 5 -- ut311Minor allele frequency- A:0.05WA 118
    rs1814374371,2
    C--124977683(+) GTTACA/GCAGCT 5 -- ut310--------
    rs1498248891,2
    --124977690(+) AGCTGC/TGTCTG 5 -- ut310--------
    rs1862654741,2
    --124977910(+) AAGACC/TTGGCC 5 -- ut310--------
    rs37504861,2
    C,F,H--124978057(+) TGGGGG/ATAGGG 5 -- ut31 ese317Minor allele frequency- A:0.14EA NS NA 3494
    rs1907337241,2
    --124978137(+) GTCACC/TGCCCT 5 -- ut310--------
    rs1458351461,2
    C--124978238(+) GCCCTA/GTTAGG 5 -- ut310--------
    rs37936171,2
    C,F,H--124978245(+) TAGGCC/TTCTCA 5 -- ut31 ese326Minor allele frequency- T:0.21EA NA NS WA 4208
    rs1827282901,2
    --124978302(+) AGACAC/GATGGA 5 -- ut310--------
    rs105688181,2
    C--124978325(+) AGAAC-/ATAGCTT 5 -- ut310--------
    rs585327161,2
    C--124978326(+) GAACA-/TAGCTTT 5 -- ut310--------
    rs1132359071,2
    C--124978462(+) AATGTA/GGGGGA 5 -- ut312Minor allele frequency- G:0.00CSA 2
    rs1878532571,2
    --124978500(+) GGCATC/TGCACA 5 -- ut310--------
    rs788270821,2
    C,F--124978501(+) GCATCG/ACACAA 5 -- ut311Minor allele frequency- A:0.02WA 118
    rs1912936231,2
    --124978594(+) CTGATA/TCCAGA 5 -- ut310--------
    rs743701881,2
    C,F--124978638(+) CTGTGG/ATGCTC 5 -- ut311Minor allele frequency- A:0.02NA 120
    rs115405161,2
    C,F--124978833(-) CTAACG/ACTGCC 7 /T ut31 syn14Minor allele frequency- A:0.02WA NA 4850
    rs2005310511,2
    --124978892(+) CTGGGC/GGCCTG 5 -- int10--------
    rs1832031171,2
    --124978907(+) ACCCTC/GCTGCC 5 -- int10--------
    rs603592381,2
    C,F--124978915(+) GCCCCC/GCAGAG 5 -- int12Minor allele frequency- G:0.24NA EA 240
    rs1157611851,2
    C--124979105(+) GAGATA/GCAACA 5 -- int10--------
    rs760301271,2
    C,F--124979258(+) AGCTCG/ATGGGC 5 -- int11Minor allele frequency- A:0.01WA 118
    rs1157465181,2
    C,F--124979355(+) CCAAGG/ATCACC 5 -- int11Minor allele frequency- A:0.05WA 118
    rs1161769681,2
    F--124979360(+) GTCACC/TGTGAC 5 -- int11Minor allele frequency- T:0.02WA 118
    rs1878764331,2
    --124979443(+) ACGAAA/GCCTAG 5 -- int10--------
    rs1921717601,2
    --124979454(+) AAGTGC/TGTGGC 5 -- int10--------
    rs1429515201,2
    --124979484(+) GATACA/CCAGTG 5 -- int10--------
    rs108186471,2
    C,F,A,H--124979572(+) ACAGCC/TAGTTC 5 -- int127Minor allele frequency- T:0.21NS EA NA WA 2772
    rs749865851,2
    C,F--124979675(+) ACATGG/ACTGTT 5 -- int11Minor allele frequency- A:0.14WA 118
    rs109855641,2
    C,F,H--124979706(+) TTACTT/CGCCCA 5 -- int126Minor allele frequency- C:0.48NS EA NA WA CSA 2765
    rs796175261,2
    C,F--124979872(+) CCTACG/AGAGTG 5 -- int11Minor allele frequency- A:0.03WA 118
    rs1843811791,2
    --124979875(+) ACGGAG/TTGGGA 5 -- int10--------
    rs1127626351,2
    C,F--124979962(+) GAGGTA/GGCAGA 5 -- int11Minor allele frequency- G:0.00CSA 1
    rs1880546111,2
    --124979978(+) GATTCC/TGAGCT 5 -- int10--------
    rs1410863341,2
    --124980102(+) AGTGGC/TGACCC 5 -- int10--------
    rs1469396581,2
    --124980182(+) TAAGAA/GCTTTC 5 -- int10--------
    rs109855651,2
    C,F,A,H--124980278(+) ATGCGG/ATGGAG 5 -- int122Minor allele frequency- A:0.23NS EA NA WA CSA 1571
    rs1925186881,2
    --124980476(+) CCTGCC/TGCCCA 5 -- int10--------
    rs1844750501,2
    --124980507(+) AGTTAC/TGGACA 5 -- int10--------
    rs1142562391,2
    C,F--124980532(+) GAGCTG/AGCGGA 5 -- int11Minor allele frequency- A:0.05WA 118
    rs1894029191,2
    --124980744(+) ACAAGC/TTTAGC 5 -- int10--------
    rs1807445401,2
    --124980758(+) GCAACC/TAGGAG 5 -- int10--------
    rs1379891641,2
    --124980880(+) CCTGTC/TGGCTC 5 -- int10--------
    rs1849655651,2
    --124980977(+) CATGCA/GGTTCT 5 -- int10--------
    rs1883540491,2
    --124981023(+) TCTCCC/GCTAGA 5 -- int10--------
    rs108186491,2
    C,F,A,H--124981111(+) CTGCCC/TACACC 5 -- int121Minor allele frequency- T:0.45NS EA NA WA CSA 2346
    rs1408012331,2
    --124981159(+) TGTCAA/GCTCAC 5 -- int10--------
    rs1815700441,2
    --124981339(+) GTCATC/TGCAAT 5 -- int10--------
    rs1159123851,2
    F--124981483(+) AGTCAT/AGTCAC 5 -- int11Minor allele frequency- A:0.03WA 118
    rs78738281,2
    C,F,A,H--124981629(+) CTATGG/AATGTG 5 -- int119Minor allele frequency- A:0.07NS EA NA CSA WA 2199
    rs760754591,2
    F--124981646(+) TCAGCG/AGCGAT 5 -- int11Minor allele frequency- A:0.02EA 120
    rs779887271,2
    C,F--124981779(+) GTGGTG/ACCCGG 5 -- int11Minor allele frequency- A:0.05EA 120
    rs1858185041,2
    --124981834(+) AGGCTC/GAGCCA 5 -- int10--------
    rs1910735301,2
    --124981875(+) CCCGGC/TTGCCC 5 -- int10--------
    rs1822934671,2
    --124981881(+) TGCCCA/GTTAGA 5 -- int10--------
    rs1501372711,2
    --124981971(+) TCTGTA/GTATTT 5 -- int10--------
    rs1860860501,2
    --124982015(+) ACCGGA/GATCTG 5 -- int10--------
    rs754911061,2
    F--124982072(+) CCCTCC/TGAGGG 5 -- int11Minor allele frequency- T:0.02WA 118
    rs750599171,2
    C,F--124982517(+) CCACAC/ATTTAC 5 -- int11Minor allele frequency- A:0.03WA 118
    rs1910852771,2
    --124982666(+) CTTTGA/GGAGGC 5 -- int10--------
    rs1385631951,2
    --124982727(+) CGTGGC/TGAAAC 5 -- int10--------
    rs1823653531,2
    --124982774(+) CATGGC/TGGTAG 5 -- int10--------
    rs1872062431,2
    C--124982888(+) CTGGGC/TGATAA 5 -- int10--------
    rs589994061,2
    C--124982928(+) AAAAA-/A/AAA 
     A
    /AAAAA
    GCAAG
    5 -- int11NA 2
    rs727677881,2
    C,F--124982966(+) GAGCTA/CTCTGG 5 -- int12Minor allele frequency- C:0.19NA 122
    rs1381592681,2
    --124982979(+) CTCAAC/TGTTCC 5 -- int10--------
    rs1902109801,2
    --124983025(+) CTTTCC/GAGGCT 5 -- int10--------
    rs1427442291,2
    --124983055(+) GCTGGC/GAGGGA 5 -- int10--------
    rs1831972281,2
    --124983058(+) GGGAGA/GGAGGT 5 -- int10--------
    rs1874549141,2
    --124983158(+) CAGAAA/GTAATA 5 -- int10--------
    rs775292251,2
    C,F--124983314(+) CAGCTC/TAGGAT 5 -- int11Minor allele frequency- T:0.03NA 120
    rs749838101,2
    F--124983446(+) AGACAG/CAGCAG 5 -- int11Minor allele frequency- C:0.01NA 120
    rs787374541,2
    C,F--124983491(+) TCGGAG/ATGGCC 5 -- int12Minor allele frequency- A:0.12CSA WA 120
    rs1460763391,2
    C--124983709(+) GGAGAG/TCGGCC 8 I L mis1 int10--------
    rs2000772451,2
    --124983723(+) CCATAC/TCGGCT 8 D G mis1 int10--------
    rs412739191,2
    C,F--124983742(+) GACGGG/TGGGTG 8 T P mis1 int12Minor allele frequency- T:0.00NA EU 5865
    rs2021839531,2
    --124983779(+) TGCCCA/GCACTG 8 C syn1 int10--------
    rs2013353331,2
    C--124983815(+) CCTTGC/GAGCTC 5 -- int10--------
    rs9897981,2
    C,F,A,H--124983838(-) ATCCTG/ATGTGC 5 -- int125Minor allele frequency- A:0.24NA NS EA WA CSA 2536
    rs1132399461,2
    C,F--124984014(+) GGCACA/GATCTT 5 -- int12Minor allele frequency- G:0.00CSA 2
    rs1931376031,2
    --124984051(+) GTTCAC/GGCCAT 5 -- int10--------
    rs1414473251,2
    --124984068(+) GCCTCA/GGCCTC 5 -- int10--------
    rs1508522031,2
    --124984073(+) AGCCTA/CCCAAG 5 -- int10--------
    rs107602121,2
    C,F,A,H--124984148(+) GTTTCG/ACCGTG 5 -- int16Minor allele frequency- A:0.29NA WA 14
    rs1455736941,2
    --124984211(+) GACGGC/TCTTGA 5 -- int10--------
    rs108186501,2
    C,F,A,H--124984239(+) ctgccT/Cgcctc 5 -- int17Minor allele frequency- C:0.47NA WA CSA 15
    rs1857582281,2
    --124984292(+) CCGGCA/CAATTG 5 -- int10--------
    rs1127568131,2
    C--124984307(+) CTCTTTATA    
       GTC
    /-
    TTATA
    5 -- int11Minor allele frequency- -:0.50CSA 2
    rs2003631631,2
    C--124984307(+) GCTCTC/TTATAA 5 -- int10--------
    rs579603871,2
    C--124984311(+) TTATAGTCT    
       ATA
    /-
    AAGAG
    5 -- int11Minor allele frequency- -:0.00NA 2
    rs1886713261,2
    --124984332(+) GTGAGA/GTATAA 5 -- int10--------
    rs109855671,2
    C,F--124984393(+) CATGCG/ACATGC 5 -- int19Minor allele frequency- A:0.20NA WA EA 370
    rs1410480421,2
    --124984406(+) GCAAGC/TCTGTA 5 -- int10--------
    rs1450236751,2
    C--124984649(+) CATTTC/TTGTTT 5 -- int10--------
    rs1927159411,2
    --124984751(+) CCCACC/TTTAGC 5 -- int10--------
    rs1165751651,2
    C,F--124984781(+) ACTGGC/AATGTA 5 -- int11Minor allele frequency- A:0.03WA 118
    rs92992781,2
    C--124984885(+) tgcccG/Acctcg 5 -- int18Minor allele frequency- A:0.00NA WA CSA 14
    rs576170161,2
    C--124984889(+) CACCTC/TGGCCT 5 -- int10--------
    rs1430535591,2
    --124984890(+) ACCTCA/GGCCTC 5 -- int10--------
    rs1113747191,2
    F--124985010(+) CACGAG/AGGCAG 5 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs1511747041,2
    --124985172(+) TGGGTC/TGGATC 5 -- int10--------
    rs1402832001,2
    C--124985215(+) ACAGCA/GGAGAA 5 -- int10--------
    rs760503541,2
    F--124985363(+) TAAAGG/AAGTTA 5 -- int11Minor allele frequency- A:0.01WA 118
    rs1454865881,2
    --124985579(+) TGGGGA/TCTGGT 5 -- int10--------
    rs1381271571,2
    --124985660(+) TAGAGC/TAAACT 5 -- int10--------
    rs789483651,2
    F--124985715(+) CACACA/CCCCCC 5 -- int11Minor allele frequency- C:0.06WA 118
    rs1841334481,2
    C--124985791(+) TCTAAA/GCAGCA 5 -- int10--------
    rs1886941301,2
    --124985950(+) ATAGCA/GCCCCT 5 -- int10--------
    rs1427069611,2
    --124986031(+) ATGTCA/GCTCCT 5 -- int10--------
    rs2010839471,2
    --124986095(+) GCAGC-/GAAG  
            
    CTGGT
    5 -- int10--------
    rs577555791,2
    C,F--124986124(+) ACTCCT/CAGTTC 5 -- int11Minor allele frequency- C:0.08WA 118
    rs108186511,2
    C,F,A,H--124986215(+) ACCTCG/ATTTGA 5 -- int128Minor allele frequency- A:0.21NS EA NA 3070
    rs1811890981,2
    --124986218(+) TCGTTG/TGATGC 5 -- int10--------
    rs1386773451,2
    --124986227(+) GCTCAC/GAACAC 5 -- int10--------
    rs792154641,2
    F--124986318(+) CACAGC/TTAGTA 5 -- int11Minor allele frequency- T:0.02WA 118
    rs1493566991,2
    --124986343(+) GATGTA/GAAGCC 5 -- int10--------
    rs1844336281,2
    --124986534(+) TTCTTC/TTTCCC 5 -- int10--------
    rs577528231,2
    C--124987092(+) CACAT-/TGCTAT 4 -- int10--------
    rs1888757771,2
    --124987113(+) CTGCTC/TCCCAG 5 -- int10--------
    rs769765291,2
    C,F--124987168(+) ATTCCG/CTTCCC 5 -- int12Minor allele frequency- C:0.14CSA WA 120
    rs1150746001,2
    C,F--124987256(+) CCACCC/TCGCAG 5 -- int11Minor allele frequency- T:0.01WA 118
    rs764075781,2
    F--124987409(+) TCTCCG/TGGCAC 5 -- int11Minor allele frequency- T:0.05WA 118
    rs773563351,2
    C,F--124987422(+) GCACAT/GTGTGG 5 -- int11Minor allele frequency- G:0.07WA 118
    rs776929241,2
    C,F--124987423(+) CACATT/AGTGGG 5 -- int11Minor allele frequency- A:0.07WA 118
    rs763386661,2
    C--124987438(+) TTGAAG/AGCATT 5 -- int12Minor allele frequency- A:0.15CSA WA 120
    rs1447151061,2
    --124987474(+) CCTCTA/GTGAAG 5 -- int10--------
    rs1485427211,2
    --124987493(+) TCCACC/TGAGGC 5 -- int10--------
    rs1815184051,2
    --124987500(+) AGGCAA/GAGCCG 5 -- int10--------
    rs1439688881,2
    C--124987584(+) CCCAAA/GGCCCT 5 -- int10--------
    rs2002721411,2
    --124987655(+) CCCAGA/CGGCTC 5 -- int10--------
    rs117896191,2
    C,F,H--124987790(+) GCCCCC/GGAGGG 10 S syn16Minor allele frequency- G:0.04NA EU WA 4333
    rs2019098621,2
    --124987871(+) AGCCTC/TGGCAG 5 -- int10--------
    rs22747481,2
    C,F,A--124987948(+) TCCTGG/CAGAAG 5 -- int18Minor allele frequency- C:0.24NA CSA WA EA 368
    rs625740501,2
    C,F--124988272(+) TCCGGG/CCCGAG 5 -- int14Minor allele frequency- C:0.04NA 126
    rs1410120501,2
    C,F--124988373(+) TTCCGC/TGGTGA 10 T A mis11Minor allele frequency- T:0.01NA 4150
    rs787719111,2
    C,F--124988530(+) GGGGTG/CGGGGG 5 -- int11Minor allele frequency- C:0.04WA 118
    rs794545921,2
    F--124988643(+) CGCTTA/GGTACT 5 -- int11Minor allele frequency- G:0.02WA 118
    rs1448820071,2
    --124988717(+) ATACAA/TGGGAG 5 -- int10--------
    rs1154360861,2
    F--124988888(+) GCTCCT/AAATTT 5 -- int11Minor allele frequency- A:0.04WA 118
    rs745260131,2
    C,F--124989014(+) TTTTGA/GGGTAT 5 -- int11Minor allele frequency- G:0.04WA 118
    rs10043081,2
    C,F,A,H--124989071(+) TTAACC/TGGCGT 5 -- int119Minor allele frequency- T:0.18NS EA NA CSA WA 2344
    rs1874124881,2
    C--124989074(+) ACCGGA/CGTATA 5 -- int10--------
    rs800582471,2
    F--124989121(+) AGTCAT/CACTAA 5 -- int11Minor allele frequency- C:0.03WA 118
    rs1902281991,2
    --124989197(+) AAAATG/TTCCAT 5 -- int10--------
    rs778747971,2
    F--124989415(+) TGCTTA/GCCGTC 5 -- int11Minor allele frequency- G:0.03WA 118
    rs1810565201,2
    --124989417(+) CTTACC/TGTCTT 5 -- int10--------
    rs48379491,2
    C,F,A,H--124989418(+) TTACCA/GTCTTT 5 -- int128Minor allele frequency- G:0.46NS EA NA WA CSA 2539
    rs1149988011,2
    F--124989441(+) ACAATG/AAACGT 5 -- int11Minor allele frequency- A:0.02WA 118
    rs786448601,2
    F--124989522(+) GAGATC/TGGAGG 5 -- int11Minor allele frequency- T:0.01EA 120
    rs1853011771,2
    --124989677(+) TGTGGC/GAAAGC 5 -- int10--------
    rs74689471,2
    C,F--124989808(+) CCTTAG/AACCCA 5 -- int19Minor allele frequency- A:0.28NA CSA WA EA 369
    rs1903694821,2
    --124989969(+) AGACAA/CTCTGT 5 -- int10--------
    rs1394466141,2
    C--124990070(+) AGAAGA/CCTCCT 5 -- int10--------
    rs117911941,2
    C,H--124990129(+) GGTGTG/CGTATG 5 -- int17Minor allele frequency- C:0.07NS EA NA 620
    rs1156737221,2
    C,F--124990398(+) ATCCCA/GTCTGT 5 -- int11Minor allele frequency- G:0.04WA 118
    rs78681471,2
    C,F,A--124990542(+) GGCCCA/GGAGAG 5 -- int1 trp310Minor allele frequency- G:0.28NA WA CSA EA 372
    rs1496701641,2
    --124990686(+) GCTAGA/GATAGG 5 -- int10--------
    rs755448411,2
    F--124990722(+) TCTCTC/TCAGGA 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1455021211,2
    --124990763(+) GGGGAA/TGAGCC 5 -- int10--------
    rs743430131,2
    C,F--124990863(+) CAACAC/TATCAG 5 -- int12Minor allele frequency- T:0.05CSA WA 119
    rs1403144871,2
    --124990929(+) GGAAAA/CATAGT 5 -- int10--------
    rs1995105101,2
    C--124990973(+) GCAAA-/GATCGA 5 -- int10--------
    rs1826278691,2
    --124990981(+) CGACCC/TGGAAG 5 -- int10--------
    rs1180591251,2
    C,F--124991069(+) GGGTGG/TTTCCT 5 -- int11Minor allele frequency- T:0.03EA 120
    rs2014683831,2
    --124991219(+) GACCAA/GGCCGA 9 L syn1 ut510--------
    rs1418305771,2
    C,F--124991250(+) TGGCGC/TTTGCA 9 K syn1 ut512Minor allele frequency- T:0.00NA EU 5875
    rs1163453801,2
    C,F--124991268(+) CAGGCG/AAAGCA 9 /F syn1 ut511Minor allele frequency- A:0.01WA 216
    rs1997366821,2
    C--124991410(+) ACAGGC/TCAACC 5 -- int10--------
    rs1855783571,2
    --124991684(+) AAGCAA/GGTTGT 5 -- int10--------
    rs109855681,2
    C,F,H--124991823(+) TGCAAT/CGATAG 5 -- int127Minor allele frequency- C:0.13NS EA NA WA 3188
    rs1464754171,2
    --124991892(+) GTGCAC/GTTTCT 5 -- int10--------
    rs107602131,2
    C,F,A,H--124991927(+) TACTGG/ACTTTG 5 -- int124Minor allele frequency- A:0.28NS EA NA WA CSA 2352
    rs1919738591,2
    --124992007(+) GCAATA/GACTAC 5 -- int10--------
    rs1832341991,2
    --124992105(+) AAAAAG/TACAAA 5 -- int10--------
    rs1410130481,2
    C--124992120(+) AAAATA/TAAAAG 5 -- int10--------
    rs783531071,2
    C,F--124992133(+) CAGATC/TGAATG 5 -- int11Minor allele frequency- T:0.06WA 118
    rs1890846541,2
    --124992185(+) CTTCTC/TCCTTC 5 -- int10--------
    rs1930778941,2
    --124992250(+) CCCCTC/TCAGGA 5 -- int10--------
    rs78468441,2
    C,F,A--124992259(+) GAGGCA/GGCGGA 5 -- int19Minor allele frequency- G:0.15NA WA EA 482
    rs1165407101,2
    F--124992309(+) ATCCCG/CGGCAC 5 -- int11Minor allele frequency- C:0.02WA 118
    rs557774491,2
    C--124992316(+) AACACC/-CCCCC 3 -- us2k11Minor allele frequency- -:0.00NA 2
    rs9329231,2
    C,F--124992330(-) TTAAAG/AAACAC 5 -- int14Minor allele frequency- A:0.02NA WA 260
    rs9329221,2
    C,F,A,H--124992345(-) GGTGAG/CTCATC 5 -- int110Minor allele frequency- C:0.32NS EA NA CSA WA 776
    rs1147924331,2
    F--124992499(+) TCATCG/AATGCT 5 -- int11Minor allele frequency- A:0.03WA 118
    rs59005161,2
    C--124992543(+) atctc-/CTTctcac 5 -- int10--------
    rs1823434441,2
    --124992734(+) GTGGCC/TCCACT 5 -- int10--------
    rs109855691,2
    C,F--124992762(+) TCCAAA/GACCCT 5 -- int11Minor allele frequency- G:0.02EA 120
    rs1431714401,2
    --124992789(+) CAAGCA/GACCAC 5 -- int10--------
    rs1482772411,2
    --124992860(+) TGTGTC/TCCAGT 5 -- int10--------
    rs1414071081,2
    C--124992966(+) TCCCAC/TGGCAC 5 -- int10--------
    rs1865809201,2
    --124993118(+) CAGGGC/GGGGCA 5 -- int10--------
    rs122375531,2
    C,F,H--124993190(+) AAAAGG/TCTCTG 5 -- int17Minor allele frequency- T:0.14NS EA WA NA 638
    rs727677931,2
    C,F--124993359(+) TCCGCA/GGGCGG 5 -- int15Minor allele frequency- G:0.20NA WA EA 362
    rs37936181,2
    C,F,A,H--124993466(+) GAGTGC/TCCAGC 5 -- int119Minor allele frequency- T:0.25EA NA NS CSA WA 2582
    rs37936191,2
    C,F,A,H--124993708(+) CTGGGC/GCTCAA 5 -- int19Minor allele frequency- G:0.28NS NA CSA WA EA 484
    rs1918230221,2
    --124993830(+) ACAGGA/GTATGA 5 -- int10--------
    rs1840426831,2
    --124993883(+) AACCTA/GCGGAG 5 -- int10--------
    rs1884321691,2
    --124993887(+) TGCGGA/GGCAAC 5 -- int10--------
    rs1167652041,2
    F--124993964(+) GCCGCG/CTCCTC 5 -- int11Minor allele frequency- C:0.04WA 118
    rs1931655811,2
    C--124994046(+) GCGTCA/CTCAGG 5 -- int10--------
    rs1178799571,2
    F--124994264(+) CCTCAT/AACCCT 5 -- int11Minor allele frequency- A:0.03NA 120
    rs14677371,2
    C,F,A,H--124994297(-) TGAGAG/ATTCAC 5 -- int131Minor allele frequency- A:0.43NS EA NA WA CSA 4471
    rs1504098181,2
    --124994620(+) TCGGCA/GGCGGA 5 -- int10--------
    rs1851362521,2
    --124994755(+) GCGTGG/TGAAGG 5 -- int10--------
    rs1177208521,2
    F--124994884(+) GAGCAG/AAGATA 5 -- int11Minor allele frequency- A:0.01NA 120
    rs1908258981,2
    --124994968(+) TGCTGA/GATACC 5 -- int10--------
    rs1820101441,2
    --124994972(+) GGATAC/TCTAGT 5 -- int10--------
    rs1166483911,2
    C,F--124995143(+) CGAGAG/AGCCGA 5 -- int1 ut511Minor allele frequency- A:0.01WA 118
    rs1854604191,2
    --124995232(+) TTGGAA/GGTGGG 5 -- int1 ut510--------
    rs588976971,2
    C--124995303(+) GGGGGA/GAAAAA 5 -- int1 ut510--------
    rs9139341,2
    C,F--124995581(-) CTTCAG/TGCAAG 5 -- int1 ut5115Minor allele frequency- T:0.14NA WA CSA EA 513
    rs756658281,2
    F--124995768(+) CTCTGA/TGGTCA 5 -- int1 ut511Minor allele frequency- T:0.01EA 120
    rs1142611381,2
    F--124995833(+) CGGGCG/ATGCCA 5 -- int1 us2k11Minor allele frequency- A:0.03WA 118
    rs1883573021,2
    --124995877(+) AGAGGG/TGCCCC 5 -- int1 us2k10--------
    rs736630521,2
    C,F--124995884(+) CCCCAC/TGATGC 5 -- int1 us2k12Minor allele frequency- T:0.03WA 120
    rs1382121041,2
    --124995885(+) CCCACA/GATGCA 5 -- int1 us2k10--------
    rs37936211,2
    C,F,A,H--124995922(+) TATAGA/GAGAGT 5 -- int1 us2k125Minor allele frequency- G:0.38NS EA NA WA CSA 2354
    rs1439348961,2
    --124996033(+) TCCTCA/GATCCC 5 -- int1 us2k10--------
    rs798090511,2
    F--124996196(+) GTAAGC/TAATGG 5 -- int1 us2k11Minor allele frequency- T:0.03WA 118
    rs1472749521,2
    --124996361(+) AATGTA/GAATGT 5 -- int1 us2k10--------
    rs48379501,2
    C,F,A--124996386(+) CTATTT/CTTCCT 5 -- int1 us2k1 trp315Minor allele frequency- C:0.02NA WA CSA EA 516
    rs1115308741,2
    F--124996486(+) CTGGTG/TGTATT 5 -- int1 us2k12Minor allele frequency- T:0.03CSA WA 120
    rs2016838891,2
    --124996489(+) TGGTA-/TTTTTT 5 -- int1 us2k10--------
    rs1807700331,2
    --124996511(+) GGAATC/TTCAGG 5 -- int1 us2k10--------
    rs1857217381,2
    --124996523(+) AGTAAA/GGGGAG 5 -- int1 us2k10--------
    rs783969431,2
    F--124996616(+) GCCTGG/ACCAAG 5 -- int1 us2k12Minor allele frequency- A:0.05CSA WA 120
    rs1133846861,2
    F--124996627(+) GACACG/ACAGCC 5 -- int1 us2k12Minor allele frequency- A:0.04CSA WA 120
    rs735533761,2
    C,F--124996857(+) ACCCTC/GTTCCC 5 -- int1 us2k13Minor allele frequency- G:0.15WA 122
    rs123451551,2
    C,F,A,H--124997047(+) GAGAAT/CCTCAG 5 -- int1 us2k125Minor allele frequency- C:0.30NS EA NA WA CSA 2352
    rs1910114921,2
    --124997105(+) TCCCAC/TGCCAC 5 -- int1 us2k10--------
    rs1391939011,2
    C--124997121(+) ACACTC/GTCTCC 5 -- int1 us2k10--------
    rs1432329081,2
    --124997145(+) TCATAA/GCAGCC 5 -- int1 us2k10--------
    rs1162444131,2
    C,F--124997230(+) TTTGTG/AGGTTT 5 -- int1 us2k11Minor allele frequency- A:0.03WA 118
    rs1838151111,2
    --124997233(+) GTGGGC/TTTTAT 5 -- int1 us2k10--------
    rs1448202961,2
    --124997486(+) AGCTGC/TGTGGG 5 -- int1 us2k10--------
    rs1867297541,2
    --124997516(+) GTGCCC/GAGCAT 5 -- int1 us2k10--------
    rs1485935111,2
    C--124997546(+) AACAGC/TGATAA 5 -- int1 us2k10--------
    rs108186521,2
    C,F,A,H--124997582(+) TTAGGG/AAGCCT 5 -- int1 us2k127Minor allele frequency- A:0.34NS EA NA WA 3070
    rs1420604121,2
    --124997605(+) CCCCCC/TAACAG 5 -- int1 us2k10--------
    rs15562141,2
    C,F,H--124997659(+) ACTAAG/AGGCCG 5 -- int1 us2k19Minor allele frequency- A:0.06NS EA NA WA 680
    rs1924144071,2
    --124997789(+) ATAAGC/GGGAGG 5 -- int1 us2k10--------
    rs735533841,2
    C,F--124997933(+) TGAATA/CAGACT 4 -- int13Minor allele frequency- C:0.16NA WA 124
    rs1507300881,2
    --124998071(+) GGAGCC/TCCCAA 4 -- int10--------
    rs1831808951,2
    --124998076(+) CCCCAA/GGCATC 4 -- int10--------
    rs1391070881,2
    C--124998101(+) TTTGTA/GTGTTT 4 -- int10--------
    rs1440173161,2
    --124998189(+) ATGTCC/TGCCTC 4 -- int10--------
    rs1876018891,2
    C--124998231(+) CCTGAA/GTAGCT 4 -- int10--------
    rs1464602461,2
    --124998371(+) GCTGCA/GATTAT 4 -- int10--------
    rs1409737521,2
    --124998399(+) CCCGGA/CCCATC 4 -- int10--------
    rs1497285121,2
    --124998511(+) GGGACA/GGTGAG 4 -- int10--------
    rs1388334201,2
    C--124998563(+) TGACT-/ACACACA 4 -- int10--------
    rs1173989271,2
    F--124998585(+) CAGCCG/ATCCAG 4 -- int11Minor allele frequency- A:0.01EA 120
    rs347249231,2
    C,F--124998644(+) GGAGGC/-CCTTA 4 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1456056201,2
    --124998739(+) TCCTAC/GTCCAG 4 -- int10--------
    rs109855741,2
    C--124998770(+) CTTTGC/TGTGCA 4 -- int14Minor allele frequency- T:0.05CSA WA NA EA 360
    rs1489148901,2
    --124998776(+) GTGCAC/TGTGCA 4 -- int10--------
    rs1116330791,2
    F--124998783(+) TGCACG/ACACAC 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs1382537001,2
    --124998939(+) GCACTA/GCTGCA 4 -- int10--------
    rs1913620501,2
    --124999020(+) CCCCAC/GCCCAC 4 -- int10--------
    rs1820761611,2
    --124999200(+) AGATCA/GCCTTC 4 -- int10--------
    rs1492638141,2
    C--124999247(+) CAGGG-/CAGTCTG 4 -- int10--------
    rs1154545741,2
    C,F--124999319(+) GGAGGG/ATAGTT 4 -- int11Minor allele frequency- A:0.07WA 118
    rs1423423081,2
    C--124999384(+) TCTCAA/GGAAGT 4 -- int10--------
    rs70265431,2
    C,F,H--124999390(+) GAAGTA/GATTCT 4 -- int114Minor allele frequency- G:0.12NS EA NA WA CSA 842
    rs1464954661,2
    --124999437(+) CAAGCC/TTCAGG 4 -- int10--------
    rs1391560151,2
    --124999595(+) GGCTGC/TTCTCG 4 -- int10--------
    rs1383238491,2
    C--124999879(+) GGCGCC/TTGGGT 4 -- int10--------
    rs1496306451,2
    --124999885(+) TGGGTA/GTGGGA 4 -- int10--------
    rs1146279051,2
    F--124999919(+) CTGGTG/ACTTTG 4 -- int11Minor allele frequency- A:0.03WA 118
    rs1884308961,2
    --124999930(+) GGCTGA/GACCAG 4 -- int10--------
    rs1385085341,2
    --124999979(+) AAGAGG/TCCGAA 4 -- int10--------
    rs1853972761,2
    --125000329(+) GCTGCA/GCGCCG 4 -- int10--------
    rs22747491,2
    H--125000378(+) CACACG/TCCGCA 4 -- int14Minor allele frequency- T:0.00NS EA 418
    rs2016736151,2
    C,F--125000406(+) CGCCCG/AGGGCC 4 -- int11Minor allele frequency- A:0.00EU 811
    rs1141422781,2
    C--125000464(+) AGTCCA/GTCTTG 8 T M mis11Minor allele frequency- G:0.01WA 164
    rs2012252311,2
    C--125000593(+) GGGACG/CGAGGT 4 -- int11Minor allele frequency- C:0.00EU 971
    rs1899366751,2
    --125000704(+) TTTCTC/GCCGTA 4 -- int10--------
    rs1920284931,2
    --125000713(+) TAATAC/TTGAGA 4 -- int10--------
    rs1443944731,2
    --125000767(+) CCCGGA/GGGCTC 4 -- int10--------
    rs1390647801,2
    --125000802(+) AGCTTC/TGCAGT 4 -- int10--------
    rs1850070941,2
    C--125000939(+) TATCGG/TTCCAG 8 E D mis10--------
    rs1140830781,2
    C--125000951(+) ATCTCG/CAGGCC 8 /L syn11Minor allele frequency- C:0.01EA 170
    rs1388807381,2
    C--125001002(+) GAGGCG/AGCAGA 8 /A syn11Minor allele frequency- A:0.00NA 3174
    rs2008808991,2
    --125001111(+) CCTGCG/TGCGGG 4 -- int10--------
    rs1439978021,2
    C--125001284(+) CCCCAA/GCTTTT 4 -- int10--------
    rs754054621,2
    C,F--125001439(+) GGCCGG/AGCCGC 4 -- int11Minor allele frequency- A:0.05EA 120
    rs1459648871,2
    C--125001566(+) GGGAGG/TGGGGG 4 -- int1 ut510--------
    rs1892888881,2
    --125001726(+) TCTAAG/TGAAGC 4 -- int1 us2k10--------
    rs2014486341,2
    --125002569(+) CCCCC-/CGCCCCC 4 -- int1 us2k10--------
    rs713719291,2
    C--125002573(+) CCCCCC/-CCGCT 4 -- int1 us2k11Minor allele frequency- -:0.00NA 2
    rs1166471571,2
    C,F--125002605(+) ACAAGC/TACACA 4 -- int1 us2k11Minor allele frequency- T:0.14WA 118
    rs1809061991,2
    C--125003031(+) GGTCCC/TGACAA 4 -- us2k10--------
    rs1837401001,2
    --125003256(+) AGAGAC/GACACA 4 -- us2k10--------
    rs1900206121,2
    C--125003541(+) ATGTAA/GGTGAT 4 -- us2k10--------
    rs38407431,2
    C--125003542(-) TGAAC-/AGGT  
      AATCAC
    TTACA
    4 -- us2k1 tfbs30--------
    rs1811918381,2
    --125003574(+) GGGCAC/TGAGGC 4 -- us2k10--------
    rs1398816061,