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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LHX6 Gene

protein-coding   GIFtS: 51
GCID: GC09M124964

LIM Homeobox 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM Homeobox 61 2
LHX6.12 3
LIM/Homeobox Protein Lhx6.12 3
LIM Homeodomain Protein 6.12
LIM/Homeobox Protein Lhx62
LIM Homeobox Protein 63

External Ids:    HGNC: 217351   Entrez Gene: 264682   Ensembl: ENSG000001068527   OMIM: 6082155   UniProtKB: Q9UPM63   

Export aliases for LHX6 gene to outside databases

Previous GC identifers: GC09M116069 GC09M116611 GC09M118418 GC09M120340 GC09M122044 GC09M124004 GC09M094579


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LHX6 Gene:
This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich
zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the
control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript
variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants
have been identified, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for LHX6 Gene: 
LHX6 (LIM homeobox 6) is a protein-coding gene. Diseases associated with LHX6 include cervix uteri carcinoma in situ, and cervical cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX6_HUMAN, Q9UPM6
Function: Probable transcription factor required for the expression of a subset of genes involved in interneurons
migration and development. Functions in the specification of cortical interneuron subtypes and in the migration
of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity)

Gene Wiki entry for LHX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LHX6 gene promoter:
         NF-1   NF-1/L   Sox5   STAT2   STAT3   IRF-7A   CUTL1   HNF-3beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for LHX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33.2

LHX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M124964:  view genomic region     (about GC identifiers)

Start:
124,964,856 bp from pter      End:
124,991,905 bp from pter
Size:
27,050 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LHX6_HUMAN, Q9UPM6 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx6  
Size: 363 amino acids; 40045 Da
Subunit: Interacts with LDB1 (via the LIM zinc-binding domains) (By similarity)
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAI03937.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI03938.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB66505.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6PVQ1 A6PVQ2 A8K1B2 B7Z4D0 H0YN76 Q5T7S7 Q5T7S8 Q9NTK3 Q9UPM5
Alternative splicing: 6 isoforms:  Q9UPM6-1   Q9UPM6-2   Q9UPM6-3   Q9UPM6-4   Q9UPM6-5   Q9UPM6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LHX6: NX_Q9UPM6

Explore proteomics data for LHX6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPM6

  • LHX6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LHX6 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001229262.1  NP_001229263.1  NP_001229264.1  NP_055183.2  NP_954629.2  

    ENSEMBL proteins: 
     ENSP00000362860   ENSP00000362859   ENSP00000340137   ENSP00000377854   ENSP00000475927  
     ENSP00000441464   ENSP00000452811   ENSP00000453798   ENSP00000453606  

    Human Recombinant Protein Products for LHX6: 
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    Novus Biologicals LHX6 Protein
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    Cloud-Clone Corp. Proteins for LHX6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    LHX6 for ontologies           About GeneDecksing



    LHX6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UPM6

    ProtoNet protein and cluster: Q9UPM6

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LHX6_HUMAN, Q9UPM6
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    LHX6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LHX6_HUMAN, Q9UPM6
    Function: Probable transcription factor required for the expression of a subset of genes involved in interneurons
    migration and development. Functions in the specification of cortical interneuron subtypes and in the migration
    of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10393337
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    LHX6 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lhx6):
     behavior/neurological  cellular  mortality/aging  nervous system  no phenotypic analysis 
     normal 

    LHX6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lhx6tm2Vpa for LHX6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LHX6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LHX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHX6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHX6 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX6
    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX6 (see all 104):
    hsa-miR-411* hsa-miR-100* hsa-miR-3194-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-218-1* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidLHX6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LHX6
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX6
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                         Customized lentivirus expression plasmids for stable overexpression of LHX6 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LHX6

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0021799cerebral cortex radially oriented cell migration ISS--
    GO:0021800cerebral cortex tangential migration ISS--
    GO:0021853cerebral cortex GABAergic interneuron migration ISS--

    LHX6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LHX6

    Search CenterWatch for drugs/clinical trials and news about LHX6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LHX6 gene (5 alternative transcripts): 
    NM_001242333.1  NM_001242334.1  NM_001242335.1  NM_014368.4  NM_199160.3  

    Unigene Cluster for LHX6:

    LIM homeobox 6
    Hs.103137  [show with all ESTs]
    Unigene Representative Sequence: NM_001242335
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373755(uc010mvw.3) ENST00000373754(uc022bmx.1) ENST00000340587(uc004bly.4)
    ENST00000394319(uc004blx.4) ENST00000559895(uc022bmw.1) ENST00000541397
    ENST00000464484 ENST00000482062 ENST00000558672 ENST00000560152 ENST00000560485
    ENST00000559529
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX6
    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX6 (see all 104):
    hsa-miR-411* hsa-miR-100* hsa-miR-3194-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-218-1* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidLHX6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LHX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX6
    Clone
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    OriGene clones in human, mouse for LHX6 (see all 13)
    OriGene ORF clones in mouse, rat for LHX6
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    GenScript: all cDNA clones in your preferred vector (see all 2): LHX6 (NM_014368)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX6
    Sirion Biotech Customized lentivirus for stable overexpression of LHX6 
                         Customized lentivirus expression plasmids for stable overexpression of LHX6 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LHX6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHX6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX6

    Additional mRNA sequence: 

    AB031041.1 AB031042.1 AK126982.1 AK289827.1 AK297175.1 AK299709.1 AK313808.1 AL136570.1 
    BC103936.1 BC103937.1 BC103938.1 

    10 DOTS entries:

    DT.412600  DT.97811234  DT.99992081  DT.121209120  DT.121209122  DT.40262865  DT.95364250  DT.121209119 
    DT.121209123  DT.121209172 

    24/50 AceView cDNA sequences (see all 50):

    AI265821 W61009 BU540587 AA136365 NM_014368 AA128312 AL136570 AK126982 
    BX089771 AI186377 NM_199160 BQ003604 AI269647 AI279977 BI251909 AA128255 
    BQ649909 AB031041 AA125840 AA125856 BI913711 AA806126 BM928350 AW629363 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for LHX6 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c · 14d
    SP1:                                -           -           -     -                       -                       -     -                                       
    SP2:                                -           -           -     -                       -                       -     -           -                           
    SP3:                                                              -                       -                       -     -                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for LHX6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LHX6 expression in normal human tissues (normalized intensities)      LHX6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGTGCTTTG
    LHX6 Expression
    About this image


    LHX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 23 entries
             Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
             Thalamus
             Human Brain Microvascular Endothelial Cells (HBMEC)   
             Septum   
     
     Endothelium (Cardiovascular System)    fully expand to see all 11 entries
             PureStem endothelial Progenitor 30-SM2-3
             Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Medial Ganglionic Eminence Progenitor Cells Medial Ganglionic Eminence
             Telencephalon
     
     Tooth
             Dental Papilla Cells Dental Papilla
             mouse/organ system/integumental system   
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Cranial Neural Crest Cells Branchial Arch 1

    See LHX6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LHX6

    SOURCE GeneReport for Unigene cluster: Hs.103137
        SABiosciences Custom PCR Arrays for LHX6
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LHX6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhx61 , 5 LIM homeobox protein 61, 5 92.35(n)1
    97.96(a)1
      2 (24.17 cM)5
    168741  NM_008500.21  NP_032526.21 
     360819505 
    chicken
    (Gallus gallus)
    Aves LHX61 LIM homeobox 6 78.73(n)
    84.97(a)
      772259  XM_001235420.2  XP_001235421.2 
    zebrafish
    (Danio rerio)
    Actinopterygii lhx61 LIM homeobox 6 72.86(n)
    79.6(a)
      445565  NM_001004015.1  NP_001004015.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Awh3 transcription factor 48(a)   63F4   --
    worm
    (Caenorhabditis elegans)
    Secernentea lim-43 LIM-homeodomain 44(a)   X(3905023-3905852)   --


    ENSEMBL Gene Tree for LHX6 (if available)
    TreeFam Gene Tree for LHX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LHX6 gene
    ISL12  LMO22  LHX22  LHX92  LMX1B2  LHX52  LMO12  LMO42  
    LHX12  LMX1A2  LMO32  LHX32  LHX42  LHX82  ISL22  
    18/23 SIMAP similar genes for LHX6 using alignment to 8 protein entries:     LHX6_HUMAN (see all proteins) (see all similar genes):
    LHX8    LHX4    Lhx8    LIMD1    LHX3    LHx4
    LMO1    LMO3    ISL1    ISL2    LHX2    LMO4
    LHX1    POU6F1    TRIP6    CSRP1    LIMK1    WTIP

    LHX6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/489 SNPs in LHX6 are shown (see all 489)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134028241,2
    C,F--124970985(+) GTAGGT/CGCCTG 5 -- int11Minor allele frequency- C:0.00CSA 1
    rs343554041,2
    C--124971114(+) TGTCT-/AAAAAA 5 -- int11Minor allele frequency- A:0.50NA 2
    rs604281821,2
    C--124974376(+) TACTT-/TATGCG 5 -- int10--------
    rs802760471,2
    C,F--124976235(+) CCCCAC/TCCTCT 5 -- int11Minor allele frequency- T:0.09WA 118
    rs1860596311,2
    --124976267(+) TCTCAC/TCTGAT 5 -- int10--------
    rs1897811541,2
    --124976335(+) CTCCTC/TCAGGA 5 -- int10--------
    rs735533561,2
    C,F--124976343(+) GGACAA/GGGTCT 5 -- int13Minor allele frequency- G:0.15WA CSA 122
    rs1394623911,2
    --124976573(+) TACACC/TGTCCA 5 -- int10--------
    rs1812193561,2
    --124976610(+) GACCTA/TAGCCC 5 -- int10--------
    rs794573161,2
    --124976733(+) TGAAAG/TGTATG 5 -- ut311Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for LHX6 (124964856 - 124991905 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LHX6:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv8280n71CNV Loss21882294
    nsv831715CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608215    OMIM disorders: --

    5 diseases for LHX6:    About MalaCards
    cervix uteri carcinoma in situ    cervical cancer    cerebritis    cervicitis
    neuronitis


    LHX6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LHX6
    Human Genome Epidemiology (HuGE) Navigator: LHX6 (2 documents)

    Export disorders for LHX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LHX6 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with LHX6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. (PubMed id 10393337)1, 2, 3, 9 Kimura N.... Taga T. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. The LIM homeodomain transcription factor LHX6: a trans criptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulat e odontogenesis. (PubMed id 23229549)1 Zhang Z....Amendt B.A. (2013)
    9. Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. (PubMed id 22435649)1 Paschou P....Grigoriou M. (2012)
    10. Epigenetic regulation of the potential tumor suppress or gene, hLHX6.1, in human cervical cancer. (PubMed id 21240459)1 Jung S....Lee M.S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26468 HGNC: 21735 AceView: LHX6 Ensembl:ENSG00000106852 euGenes: HUgn26468
    ECgene: LHX6 H-InvDB: LHX6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LHX6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LHX6 gene:
    Search GeneIP for patents involving LHX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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