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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LHX5 Gene

protein-coding GIFtS: 51
GCID: GC12M113900

LIM homeobox 5

Explore 2 diseases affiliated with
LHX5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
LIM Homeobox 5¹ ²
LIM Homeobox Protein 5² ³
LIM/Homeobox Protein Lhx5²

External Ids:	HGNC: 14216¹	Entrez Gene: 64211²	Ensembl: ENSG00000089116⁷	OMIM: 605992⁵	UniProtKB: Q9H2C1³

Export aliases for LHX5 gene to outside databases

Previous GC identifers: GC12M112809 GC12M113419 GC12M113683 GC12M112312 GC12M112363 GC12M110911

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LHX5:

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique

cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in

the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation

of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal

development. This protein is involved in learning and motor functions in adult mice. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1

Function: Plays an essential role in the regulation of neuronal differentiation and migration during development of the

central nervous system

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LHX5 gene promoter:
E2F-4 E2F-3a E2F-5 NRSF form 1 E2F-2 NRSF form 2 AREB6 E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LHX5 promoter sequence

Search SABiosciences Chromatin IP Primers for LHX5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24 Ensembl cytogenetic band: 12q24.13 HGNC cytogenetic band: 12q24.13

LHX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX5 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M113900: view genomic region (about GC identifiers)

Start:	113,899,838 bp from pter	End:	113,910,085 bp from pter
Size:	10,248 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1 (See protein sequence)

Recommended Name: LIM/homeobox protein Lhx5

Size: 402 amino acids; 44406 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: Q32MA4

Explore the universe of human proteins at neXtProt for LHX5: NX_Q9H2C1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H2C1

LHX5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_071758.1

ENSEMBL proteins:

ENSP00000261731

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	Novus Biologicals LHX5 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LHX5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

LHX5 for ontologies About GeneDecksing

LHX5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LHX5
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	GenScript Custom Superior Antibodies Services for LHX5
	Novus Biologicals LHX5 Antibodies
	Search for Antibodies for LHX5 at Abcam
	Uscn Antibodies for LHX5
	Search ThermoFisher Antibodies for LHX5

Assay Products for LHX5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LHX5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LHX5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LHX5 for domains About GeneDecksing

4 InterPro domains/families:

IPR001781 Znf_LIM

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9H2C1

ProtoNet protein and cluster: Q9H2C1

2 Blocks protein families:

IPB000047 Lambda and other repressor helix-turn-helix signature

IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 2 LIM zinc-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1

Function: Plays an essential role in the regulation of neuronal differentiation and migration during development of the

central nervous system

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX5
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX5:
		hsa-miR-9 hsa-miR-659 hsa-miR-133a hsa-miR-133b
		SwitchGear 3'UTR luciferase reporter plasmid: LHX5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX5 (see all 7) OriGene shRNA RFP: LHX5 OriGene siRNA: LHX5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LHX5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX5 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LHX5 (NM_022363)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LHX5
		Search LifeMap BioReagents cell lines for LHX5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX5

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

LHX5 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Lhx5^tm1Lmgd for LHX5
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lhx5):

cellular

homeostasis/metabolism

mortality/aging

nervous system

LHX5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription factors in neurogenesis

Transcription factors in neurogenesis

1.00

Neural Crest Differentiation

Neural Crest Differentiation

1.00

Transcriptional Regulatory Network in Embryonic Stem Cell

Transcriptional Regulatory Network in Embryonic Stem Cell

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for LHX5

Transcription factors in neurogenesis

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LHX5

Transcriptional Regulatory Network in Embryonic Stem Cell

1 BioSystems Pathway for LHX5

Neural Crest Differentiation

LHX5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LHX5

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for LHX5 (Q9H2C1³ ENSP00000261731⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LDB1	Q86U70³, ENSP00000392466⁴	I2D: score=1 STRING: ENSP00000392466
LDB2	O43679³	I2D: score=1

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007267	cell-cell signaling	--	--
GO:0021527	spinal cord association neuron differentiation	IEA	--
GO:0021549	cerebellum development	--	--
GO:0021702	cerebellar Purkinje cell differentiation	IEA	--

LHX5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LHX5
Search CenterWatch for drugs/clinical trials and news about LHX5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LHX5 gene:

NM_022363.2

Unigene Cluster for LHX5:

LIM homeobox 5

Hs.302029 [show with all ESTs]

Unigene Representative Sequence: NM_022363

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261731(uc001tvj.1) ENST00000557836

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX5
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX5:
		hsa-miR-9 hsa-miR-659 hsa-miR-133a hsa-miR-133b
		SwitchGear 3'UTR luciferase reporter plasmid: LHX5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX5 (see all 7) OriGene shRNA RFP: LHX5 OriGene siRNA: LHX5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX5 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LHX5 (NM_022363)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LHX5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX5

Additional cDNA sequence:

AF291181.1 BC109230.2

1 DOTS entry:

DT.102835918

2 AceView cDNA sequences:

AF291181 NM_022363

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LHX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCGGCGAGG

About this image

LHX5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Diencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LHX5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LHX5

SOURCE GeneReport for Unigene cluster: Hs.302029

UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1

Tissue specificity: Expressed in fetal brain and in various regions of the adult central nervous system including the

spinal cord, the thalamus, and the cerebellum

SABiosciences Custom PCR Arrays for LHX5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LHX5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LHX5 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LHX5¹	LIM homeobox 5	82.59(n) 90.8(a)		771259 XM_001234552.2 XP_001234553.2
lizard (Anolis carolinensis)	Reptilia	LHX5⁶ LHX1⁶	--	91(a) 69(a)	1 ↔ 1 possible ortholog	GL343338.1(906026-916767) GL343439.1(343916-360576)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1047²	Xenopus laevis LIM class homeodomain protein (lim5/Lhx5) more	73.61(n)		L42546.1
zebrafish (Danio rerio)	Actinopterygii	lhx5²	LIM homeobox 5	74.99(n)		30465 L42547.1
fruit fly (Drosophila melanogaster)	Insecta	Lim1³	leg disc proximal/distal pattern formation transcription more	46(a)		--
worm (Caenorhabditis elegans)	Secernentea	lin-11³	LIM domain containing proteins (2 domains), homeobox more	52(a) (best of 2)		I(10256239-10258192) --

ENSEMBL Gene Tree for LHX5 (if available)
TreeFam Gene Tree for LHX5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LHX5 gene

LMO2² ISL1² LHX2² LHX9² LMX1B² LMO1² LMO4² LHX6²

LHX1² LMX1A² LMO3² LHX4² LHX3² LHX8² ISL2²

11 SIMAP similar genes for LHX5 using alignment to 1 protein entry: LHX5_HUMAN:

LHX1 LMO2 POU6F1 LHX9 LMX1B LHX2

LMX1A ISL1 LHX4 LHX3 ISL2

LHX5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144024513^1,2		--	113900225(+)	`AGTCCA/GGCCTG`	1	--	ds500¹		0	--	--	--	--
rs115283008^1,2	F,	--	113900294(+)	`GCCACT/GTCCTG`	1	--	ds500¹		1		WA	118
rs146449424^1,2		--	113900385(+)	`GTCTCC/TCTCTC`	1	--	ds500¹		0	--	--	--	--
rs182980779^1,2		--	113900828(+)	`CCCCCC/TCTCGG`	1	--	ut3¹		0	--	--	--	--
rs12319643^1,2	C	--	113900852(+)	`AGCAGC/ATGCCA`	1	--	ut3¹ ese³		2		NA	4
rs140791986^1,2		--	113900880(+)	`GAGAGA/GACCCC`	1	--	ut3¹		0	--	--	--	--
rs187656376^1,2		--	113901114(+)	`GGGCAC/TGGGGT`	2	M V	mis¹		0	--	--	--	--
rs191028909^1,2		--	113901378(+)	`GGAGCA/GGGAAG`	1	--	int¹		0	--	--	--	--
rs11608652^1,2	C,F,H,	--	113901380(+)	`AGCGGA/C/GAAGGA`	1	--	int¹ trp³		1		NA	120
rs35800617^1,2	C,F,	--	113901431(+)	`CGGGAT/CCCGGG`	1	--	int¹		3		NA	6

HapMap Linkage Disequilibrium report for LHX5 (113899838 - 113910085 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LHX5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LHX5

DNA2.0 Custom Variant and Variant Library Synthesis for LHX5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LHX5 for disorders           About GeneDecksing

OMIM gene information: 605992    OMIM disorders: --

2 diseases for LHX5:    About MalaCards

neuronitis bipolar disorder

1 disease from the University of Copenhagen DISEASES database for LHX5:

Keratosis follicularis

Export disorders for LHX5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LHX5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LHX5)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genomic structure, chromosomal localization and expression of the human LIM-homeobox gene LHX5. (PubMed id 11137295)^{1, 2} Zhao Y.... Westphal H. (2000)
Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5. (PubMed id 12782966)¹ Green E.K....Craddock N. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Learning impairments and motor dysfunctions in adult Lhx5-deficient mice displaying hippocampal disorganization. (PubMed id 11566211)¹ Paylor R....Crawley J.N. (2001)
Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5. (PubMed id 10325223)¹ Zhao Y....Westphal H. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64211	HGNC: 14216	AceView: LHX5	Ensembl:ENSG00000089116	euGenes: HUgn64211
ECgene: LHX5	H-InvDB: LHX5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LHX5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LHX5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LHX5 gene:
Search GeneIP for patents involving LHX5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
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	Browse OriGene Antibodies		OriGene shRNA RFP for LHX5
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	OriGene Custom Antibody Services for LHX5		OriGene Custom Protein Services for LHX5
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LHX5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LHX5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX5

	GenScript Custom Purified and Recombinant Proteins Services for LHX5		GenScript cDNA clones with any tag delivered in your preferred vector for LHX5
	GenScript Custom Assay Services for LHX5		GenScript Custom Superior Antibodies Services for LHX5
	GenScript Custom overexpressing Cell Line Services for LHX5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX5

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LHX5 gene at Home site.

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LHX5 Gene

LIM homeobox 5

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LHX5 Gene

LIM homeobox 5

Aliasesfor LHX5 gene

Summariesfor LHX5 gene

Genomic Viewsfor LHX5 gene

Proteinsfor LHX5 gene

Protein Domains /Familiesfor LHX5 gene

Functionfor LHX5 gene

Pathways & Interactionsfor LHX5 gene

Drugs & Compoundsfor LHX5 gene

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for LHX5 gene

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for LHX5 gene

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for LHX5 gene

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for LHX5 gene

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for LHX5 gene

Pathways & Interactions
for LHX5 gene

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for LHX5 gene

Transcripts
for LHX5 gene

Expression
for LHX5 gene

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for LHX5 gene

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for LHX5 gene

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for LHX5 gene

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for LHX5 gene

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for LHX5 gene

Intellectual Property
for LHX5 gene

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for LHX5 gene