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LHX5 Gene

protein-coding   GIFtS: 52
GCID: GC12M113900

LIM Homeobox 5

  See LHX5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Homeobox 51 2
LIM Homeobox Protein 52 3
LIM/Homeobox Protein Lhx52

External Ids:    HGNC: 142161   Entrez Gene: 642112   Ensembl: ENSG000000891167   OMIM: 6059925   UniProtKB: Q9H2C13   

Export aliases for LHX5 gene to outside databases

Previous GC identifers: GC12M112809 GC12M113419 GC12M113683 GC12M112312 GC12M112363 GC12M110911


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LHX5 Gene:
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique
cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be
involved in the control of differentiation and development of the forebrain. In mice, this protein is essential
for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration
during hippocampal development. This protein is involved in learning and motor functions in adult mice. (provided
by RefSeq, Jul 2008)

GeneCards Summary for LHX5 Gene:
LHX5 (LIM homeobox 5) is a protein-coding gene. Diseases associated with LHX5 include keratosis follicularis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1
Function: Plays an essential role in the regulation of neuronal differentiation and migration during development
of the central nervous system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LHX5 gene promoter:
         E2F-4   E2F-3a   E2F-5   NRSF form 1   E2F-2   NRSF form 2   AREB6   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX5 promoter sequence
   Search Chromatin IP Primers for LHX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.13

LHX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M113900:  view genomic region     (about GC identifiers)

Start:
113,899,839 bp from pter      End:
113,910,085 bp from pter
Size:
10,247 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx5  
Size: 402 amino acids; 44406 Da
Secondary accessions: Q32MA4

Explore the universe of human proteins at neXtProt for LHX5: NX_Q9H2C1

Explore proteomics data for LHX5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LHX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071758.1  
    ENSEMBL proteins: 
     ENSP00000261731  

    LHX5 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
    OriGene Custom Protein Services for LHX5
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    Novus Biologicals LHX5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LHX5

     
    Search eBioscience for Proteins for LHX5 

     
    antibodies-online proteins for LHX5 (6 products) 

     
    antibodies-online peptides for LHX5

    LHX5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LHX5
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    Cloud-Clone Corp. Antibodies for LHX5
    ThermoFisher Antibodies for LHX5
    antibodies-online antibodies for LHX5 (39 products) 

    LHX5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LHX5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LHX5
    Cloud-Clone Corp. CLIAs for LHX5
    Search eBioscience for ELISAs for LHX5 
    antibodies-online kits for LHX5 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9H2C1

    ProtoNet protein and cluster: Q9H2C1

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with LHX5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LHX5_HUMAN, Q9H2C1
    Function: Plays an essential role in the regulation of neuronal differentiation and migration during development
    of the central nervous system

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with LHX5           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lhx5):
     cellular  homeostasis/metabolism  mortality/aging  nervous system 

    Find genes that share phenotypes with LHX5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lhx5tm1Lmgd for LHX5

       genOway: Develop your customized and physiologically relevant rodent model for LHX5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LHX5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate LHX5:
    hsa-miR-9 hsa-miR-659 hsa-miR-133a hsa-miR-133b
    SwitchGear 3'UTR luciferase reporter plasmidLHX5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LHX5
    Predesigned siRNA for gene silencing in human, mouse, rat LHX5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LHX5

    Clone
    Products:
         
    OriGene clones in human, mouse for LHX5 (see all 6)
    OriGene ORF clones in mouse, rat for LHX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LHX5 (NM_022363)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX5

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LHX5
    Browse ESI BIO Cell Lines and PureStem Progenitors for LHX5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LHX5_HUMAN, Q9H2C1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with LHX5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LHX5 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell
    2Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    3Neural Crest Differentiation
    Neural Crest Differentiation

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for LHX5
        Transcriptional Regulatory Network in Embryonic Stem Cell

    1 BioSystems Pathway for LHX5
        Neural Crest Differentiation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LHX5
    Interactions:

        Search GeneGlobe Interaction Network for LHX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for LHX5 (Q9H2C13 ENSP000002617314) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB1Q86U703, ENSP000003924664I2D: score=1 STRING: ENSP00000392466
    LDB2O436793, ENSP000003067724I2D: score=1 STRING: ENSP00000306772
    ARXENSP000003683324STRING: ENSP00000368332
    SFRP1ENSP000002207724STRING: ENSP00000220772
    SFRP5ENSP000002660664STRING: ENSP00000266066
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007267cell-cell signaling ----
    GO:0021527spinal cord association neuron differentiation IEA--
    GO:0021549cerebellum development ----

    Find genes that share ontologies with LHX5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LHX5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LHX5 gene: 
    NM_022363.2  

    Unigene Cluster for LHX5:

    LIM homeobox 5
    Hs.302029  [show with all ESTs]
    Unigene Representative Sequence: NM_022363
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261731(uc001tvj.1) ENST00000557836
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LHX5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate LHX5:
    hsa-miR-9 hsa-miR-659 hsa-miR-133a hsa-miR-133b
    SwitchGear 3'UTR luciferase reporter plasmidLHX5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LHX5
    Predesigned siRNA for gene silencing in human, mouse, rat LHX5
    Clone
    Products:
         
    OriGene clones in human, mouse for LHX5 (see all 6)
    OriGene ORF clones in mouse, rat for LHX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LHX5 (NM_022363)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LHX5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX5
      QuantiTect SYBR Green Assays in human, mouse, rat LHX5
      QuantiFast Probe-based Assays in human, mouse, rat LHX5

    Additional mRNA sequence: 

    AF291181.1 BC109230.2 

    1 DOTS entry:

    DT.102835918 

    2 AceView cDNA sequences:

    NM_022363 AF291181 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LHX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGGCGAGG
    LHX5 Expression
    About this image


    LHX5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Globus Pallidus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
             Floor plate-like cells
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
    LHX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LHX5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302029

    UniProtKB/Swiss-Prot: LHX5_HUMAN, Q9H2C1
    Tissue specificity: Expressed in fetal brain and in various regions of the adult central nervous system including
    the spinal cord, the thalamus, and the cerebellum

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LHX5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhx51 , 5 LIM homeobox protein 51, 5 90.71(n)1
    98.76(a)1
      5 (60.62 cM)5
    168731  NM_008499.51  NP_032525.11 
     1204317705 
    chicken
    (Gallus gallus)
    Aves LHX51 LIM homeobox 5 82.59(n)
    90.8(a)
      771259  XM_001234552.3  XP_001234553.2 
    lizard
    (Anolis carolinensis)
    Reptilia LHX56
    LIM homeobox 5
    91(a)
    1 ↔ 1
    GL343338.1(902622-917464)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10472 Xenopus laevis LIM class homeodomain protein (lim5/Lhx5) more 73.61(n)    L42546.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lhx52 LIM homeobox 5 74.99(n)   30465  L42547.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lim13 leg disc proximal/distal pattern
    formation transcription more
    46(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea lin-113 LIM domain containing proteins (2
    domains), homeobox more
    52(a)
    (best of 2)
      I(10256239-10258192)   --


    ENSEMBL Gene Tree for LHX5 (if available)
    TreeFam Gene Tree for LHX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LHX5 gene
    ISL12  LHX22  LHX92  LMX1B2  LHX62  LHX12  LMX1A2  LHX42  
    LHX32  LHX82  ISL22  
    11 SIMAP similar genes for LHX5 using alignment to 1 protein entry:     LHX5_HUMAN:
    LHX1    LMO2    POU6F1    LHX9    LMX1B    LHX2
    LMX1A    ISL1    LHX4    LHX3    ISL2

    Find genes that share paralogs with LHX5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LHX5 (see all 200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440245131,2
    C--113900225(+) AGTCCA/GGCCTG 1 -- ds50010--------
    rs1152830081,2
    C,F--113900294(+) GCCACT/GTCCTG 1 -- ds50011Minor allele frequency- G:0.08WA 118
    rs1464494241,2
    --113900385(+) GTCTCC/TCTCTC 1 -- ds50010--------
    rs1829807791,2
    --113900828(+) CCCCCC/TCTCGG 1 -- ut310--------
    rs123196431,2
    C--113900852(+) AGCAGC/ATGCCA 1 -- ut31 ese32Minor allele frequency- A:0.00NA 4
    rs1407919861,2
    --113900880(+) GAGAGA/GACCCC 1 -- ut310--------
    rs1876563761,2
    C--113901114(+) GGGCAC/TGGGGT 2 M V mis10--------
    rs2021314871,2
    C--113901232(+) AGCGCC/TCCCAG 2 G syn10--------
    rs2004403781,2
    C--113901361(+) TGGTAA/GTCTGC 2 D syn10--------
    rs1910289091,2
    C--113901378(+) GGAGCA/GGGAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for LHX5 (113899839 - 113910085 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LHX5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LHX5
    DNA2.0 Custom Variant and Variant Library Synthesis for LHX5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605992    OMIM disorders: --

    1 disease for LHX5:    
    About MalaCards
    keratosis follicularis

    1 disease from the University of Copenhagen DISEASES database for LHX5:
    Keratosis follicularis

    Find genes that share disorders with LHX5           About GenesLikeMe

    Genetic Association Database (GAD): LHX5

    Export disorders for LHX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LHX5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LHX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Genomic structure, chromosomal localization and expression of the human LIM-homeobox gene LHX5. (PubMed id 11137295)1, 2 Zhao Y.... Westphal H. (Gene 2000)
    3. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)4 Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
    4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    5. Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5. (PubMed id 12782966)1 Green E.K....Craddock N. (Psychiatr. Genet. 2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Learning impairments and motor dysfunctions in adult Lhx5-deficient mice displaying hippocampal disorganization. (PubMed id 11566211)1 Paylor R....Crawley J.N. (amp 2001)
    8. Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5. (PubMed id 10325223)1 Zhao Y....Westphal H. (Science 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64211 HGNC: 14216 AceView: LHX5 Ensembl:ENSG00000089116 euGenes: HUgn64211
    ECgene: LHX5 H-InvDB: LHX5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LHX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LHX5 gene:
    Search GeneIP for patents involving LHX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of LHX5
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