Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LHX3 Gene

protein-coding   GIFtS: 60
GCID: GC09M139088

LIM Homeobox 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM Homeobox 31 2     M2-LHX32
LIM Homeobox Protein 32 3     LIM/Homeobox Protein Lhx32
CPHD32 5     LIM/Homeodomain Protein LHX32
LIM32     

External Ids:    HGNC: 65951   Entrez Gene: 80222   Ensembl: ENSG000001071877   OMIM: 6005775   UniProtKB: Q9UBR43   

Export aliases for LHX3 gene to outside databases

Previous GC identifers: GC09M130237 GC09M130859 GC09M132611 GC09M134527 GC09M136314 GC09M138227 GC09M108552


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LHX3 Gene:
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding
domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron
specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Dec 2010)

GeneCards Summary for LHX3 Gene: 
LHX3 (LIM homeobox 3) is a protein-coding gene. Diseases associated with LHX3 include megaesophagus, and lhx3-related combined pituitary hormone deficiency, and among its related super-pathways are PKA activation in glucagon signalling. GO annotations related to this gene include protein binding transcription factor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX3_HUMAN, Q9UBR4
Function: Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene,
and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By
similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous
system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1

Gene Wiki entry for LHX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_019501.13  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LHX3 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LHX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for LHX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

LHX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139088:  view genomic region     (about GC identifiers)

Start:
139,088,096 bp from pter      End:
139,096,955 bp from pter
Size:
8,860 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LHX3_HUMAN, Q9UBR4 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx3  
Size: 397 amino acids; 43358 Da
Subunit: At neuronal promoters, interacts with LDB1, in motor neurons LDB1 is displaced by ISL1 and a ternary
complex is formed in which ISL1 contacts both LHX3 and LDB1 (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5TB39 Q5TB40 Q9NZB5 Q9P0I8 Q9P0I9
Alternative splicing: 2 isoforms:  Q9UBR4-1   Q9UBR4-2   

Explore the universe of human proteins at neXtProt for LHX3: NX_Q9UBR4

Explore proteomics data for LHX3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBR4

  • LHX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LHX3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055379.1  NP_835258.1  

    ENSEMBL proteins: 
     ENSP00000360811   ENSP00000360813  

    Human Recombinant Protein Products for LHX3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LHX3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for LHX3
    GenScript Custom Purified and Recombinant Proteins Services for LHX3
    Novus Biologicals LHX3 Protein
    Novus Biologicals LHX3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LHX3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    LHX3 for ontologies           About GeneDecksing



    LHX3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LHX3
    OriGene Custom Antibody Services for LHX3
    GenScript Custom Superior Antibodies Services for LHX3
    Novus Biologicals LHX3 Antibodies
    Abcam antibodies for LHX3
    Cloud-Clone Corp. Antibodies for LHX3 
    ThermoFisher Antibodies for LHX3
    LSBio Antibodies in human, mouse, rat for LHX3 

    Assay Products for LHX3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LHX3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LHX3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LHX3 
    Cloud-Clone Corp. CLIAs for LHX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UBR4

    ProtoNet protein and cluster: Q9UBR4

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LHX3_HUMAN, Q9UBR4
    Domain: The LIM domain specifically interacts with the Pit-1 POU domain and is required for synergistic
    interactions with Pit-1, but not for basal transcriptional activation events (By similarity)
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    LHX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LHX3_HUMAN, Q9UBR4
    Function: Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene,
    and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By
    similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous
    system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000988protein binding transcription factor activity ----
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
         
    LHX3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for LHX3:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased resistance to MDM2 i 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lhx3):
     craniofacial  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  homeostasis/metabolism 
     mortality/aging  nervous system  reproductive system 

    LHX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lhx3tm1Lmgd for LHX3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LHX3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LHX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHX3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHX3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX3 (see all 11):
    hsa-miR-196a* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1271 hsa-miR-888* hsa-miR-182 hsa-miR-1276 hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidLHX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LHX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LHX3
    Sirion Biotech Customized adenovirus for overexpression of LHX3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LHX3 (see all 11)
    OriGene ORF clones in mouse, rat for LHX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LHX3 (NM_178138)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX3
    Sirion Biotech Customized lentivirus for stable overexpression of LHX3 
                         Customized lentivirus expression plasmids for stable overexpression of LHX3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LHX3
    Search LifeMap BioReagents cell lines for LHX3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LHX3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PKA activation in glucagon signalling
    Development Role of Activin A in cell differentiation and proliferation0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for LHX3
        Development Role of Activin A in cell differentiation and proliferation


    1 GeneGo (Thomson Reuters) Pathway for LHX3
        Development Role of Activin A in cell differentiation and proliferation



    LHX3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LHX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for LHX3 (Q9UBR43 ENSP000003608114) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ISL1P613713, ENSP000002306584I2D: score=3 STRING: ENSP00000230658
    IFT172Q9UG013, ENSP000002605704I2D: score=2 STRING: ENSP00000260570
    LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
    RLIMQ9NVW23, ENSP000002535714I2D: score=2 STRING: ENSP00000253571
    LDB2O436793, ENSP000003067724I2D: score=1 STRING: ENSP00000306772
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001890placenta development IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0008045motor neuron axon guidance IEA--

    LHX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LHX3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LHX3

    3 Novoseek inferred chemical compound relationships for LHX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 35.3 2 12536356 (1), 11220702 (1)
    tyrosine 0 3 11255008 (2), 11279219 (1)
    cysteine 0 2 11255008 (1), 11279219 (1)

    Search CenterWatch for drugs/clinical trials and news about LHX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LHX3 gene (2 alternative transcripts): 
    NM_014564.3  NM_178138.4  

    Unigene Cluster for LHX3:

    LIM homeobox 3
    Hs.148427  [show with all ESTs]
    Unigene Representative Sequence: AB593065
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371746(uc004cgz.3 uc022bpm.1) ENST00000371748(uc004cha.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX3
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX3 (see all 11):
    hsa-miR-196a* hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1271 hsa-miR-888* hsa-miR-182 hsa-miR-1276 hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidLHX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LHX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX3
    Clone
    Products:
         
    OriGene clones in human, mouse for LHX3 (see all 11)
    OriGene ORF clones in mouse, rat for LHX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LHX3 (NM_178138)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX3
    Sirion Biotech Customized lentivirus for stable overexpression of LHX3 
                         Customized lentivirus expression plasmids for stable overexpression of LHX3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LHX3
    OriGene qSTAR qPCR primer pairs in human, mouse for LHX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX3

    Additional mRNA sequence: 

    AB593062.1 AB593063.1 AB593064.1 AB593065.1 AB593066.1 AB593067.1 AF096169.1 AF156889.1 

    3 DOTS entries:

    DT.70102453  DT.100683879  DT.121157507 

    16 AceView cDNA sequences:

    NM_014564 NM_178138 BU165468 BM799949 AF096169 AI198142 AI939381 AF156889 
    AF156888 BQ189536 BM665174 BG395220 BG473308 H52572 H52168 BE255970 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LHX3 expression in normal human tissues (normalized intensities)      LHX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTCACC
    LHX3 Expression
    About this image


    LHX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 15 entries
             V2 Neural Progenitor Cells pV2 Neural Domain
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Midbrain   
     
     Spinal Cord (Nervous System)    fully expand to see all 10 entries
             Median Motor Neurons Median Motor Column
             Neuronal progenitor cells ( Generation of motor neurons using a mouse GFP reporter...
             Dorsal Horn   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal amacrine cell p0   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See LHX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LHX3

    SOURCE GeneReport for Unigene cluster: Hs.148427
        SABiosciences Custom PCR Arrays for LHX3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LHX3
    OriGene qSTAR qPCR primer pairs in human, mouse for LHX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHX3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LHX3 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhx31 , 5 LIM homeobox protein 31, 5 88.06(n)1
    94.03(a)1
      2 (18.44 cM)5
    168711  NM_001039653.11  NP_001034742.11 
     262002125 
    chicken
    (Gallus gallus)
    Aves LHX31 LIM homeobox 3 80.14(n)
    82.75(a)
      373940  NM_001030335.1  NP_001025506.1 
    lizard
    (Anolis carolinensis)
    Reptilia LHX36
    Uncharacterized protein
    81(a)
    1 ↔ 1
    AAWZ02037440(7705-13217)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xlim-32 Xlim-3 protein 76.34(n)    Z22702.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131208.12   -- 78.49(n)   30455  NM_131208.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lim31 , 3 specific RNA polymerase II
    transcription factor3
    CG10699-PA1
    66(a)3
    61.24(n)1
    55.9(a)1
      351841  NM_165277.21  NP_724161.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-143 LIM homeobox protein 57(a)
    (best of 3)
      X(7563786-7565411)   --


    ENSEMBL Gene Tree for LHX3 (if available)
    TreeFam Gene Tree for LHX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LHX3 gene
    ISL12  LMO22  LHX22  LHX92  LMX1B2  LHX52  LMO12  LHX62  
    LMO42  LHX12  LMX1A2  LMO32  LHX42  LHX82  ISL22  
    18/19 SIMAP similar genes for LHX3 using alignment to 6 protein entries:     LHX3_HUMAN (see all proteins) (see all similar genes):
    LHx4    LHX4    LHX2    LMO3    LMO1    LHX8
    DUX4    LHX6    LIMK1    LMO4    ABLIM1    LIMS1
    LMO2    LHX1    ISL1    LMX1A    PDLIM5    LMX1B

    LHX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/259 SNPs in LHX3 are shown (see all 259)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0632404
    Pituitary hormone deficiency, combined, 3 (CPHD3)4--see VAR_0632402 A V mis40--------
    VAR_0107134
    Pituitary hormone deficiency, combined, 3 (CPHD3)4--see VAR_0107132 Y C mis40--------
    rs1048941171,2
    Cpathogenic1139124929(-) CGTGTA/GCCACC 4 Y C mis10--------
    rs32157741,2
    C--139090465(+) TCGTCC/-CCCCC 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs1885983911,2
    --139120979(+) AGCTGA/GAGAGA 2 -- ds50010--------
    rs1423035391,2
    --139121114(+) CCTGCC/TTCTCC 2 -- ds50010--------
    rs1929595481,2
    --139121124(+) CCAGGA/GACAGG 2 -- ds50010--------
    rs2021107691,2
    C--139121193(+) CTTCC-/AAGTGC 2 -- ds50010--------
    rs1134032251,2
    C,F--139121284(+) CTCAGG/CGCCCC 2 -- ds50011Minor allele frequency- C:0.50WA 2
    rs1868858681,2
    --139121420(+) GAGCTA/GATCAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LHX3 (139088096 - 139096955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for LHX3 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv8386n71CNV Loss21882294
    dgv8388n71CNV Loss21882294
    nsv469917CNV Loss18288195
    nsv894324CNV Loss21882294
    nsv894322CNV Loss21882294
    nsv894294CNV Loss21882294
    dgv8382n71CNV Loss21882294
    dgv8383n71CNV Loss21882294
    dgv8385n71CNV Loss21882294
    dgv8387n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): LHX3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LHX3
    DNA2.0 Custom Variant and Variant Library Synthesis for LHX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600577   
    OMIM disorders: 221750  
    UniProtKB/Swiss-Prot: LHX3_HUMAN, Q9UBR4
  • Pituitary hormone deficiency, combined, 3 (CPHD3) [MIM:221750]: Combined pituitary hormone deficiency is
    defined as the impaired production of growth hormone and one or more of the other five anterior pituitary
    hormones. CPHD3 is characterized by a complete deficit in all but one (adrenocorticotropin) anterior pituitary
    hormone and a rigid cervical spine leading to limited head rotation. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/23 diseases for LHX3 (see all 23):    About MalaCards
    megaesophagus    lhx3-related combined pituitary hormone deficiency    pituitary hormone deficiency, combined 3    thyrotoxicosis
    neonatal thyrotoxicosis    combined pituitary hormone deficiency    hypopituitarism    borjeson-forssman-lehmann syndrome
    pituitary hypoplasia    panhypopituitarism    kallmann syndrome    acth deficiency
    hypogonadotropism    sensorineural hearing loss    growth hormone deficiency    dwarfism
    holoprosencephaly    hypothyroidism    hypogonadism    short stature

    4 diseases from the University of Copenhagen DISEASES database for LHX3:
    Hypopituitarism     Pituitary hypoplasia     Holoprosencephaly     Neonatal thyrotoxicosis

    LHX3 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for LHX3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    panhypopituitarism 93.3 23 19337183 (2), 17327381 (2), 12173688 (1), 18157385 (1) (see all 13)
    septo-optic dysplasia 91.4 1 18291347 (1)
    hormone deficiency 87.7 3 10946868 (1), 17327381 (1), 17616267 (1)
    hypopituitarism 84.7 5 18407919 (2), 10946868 (1), 18728160 (1), 18157385 (1)
    deficiency diseases 78.9 2 12173688 (1), 19337183 (1)
    kallmann syndrome 66.2 1 12536356 (1)
    hypoplasia 58.8 2 18291347 (1)
    pituitary diseases 56.4 3 11255008 (1), 10717474 (1)
    empty sella 55.1 1 15279086 (1)
    hypothyroidism 32.7 2 12244277 (1), 15611819 (1)

    Genetic Association Database (GAD): LHX3
    Human Genome Epidemiology (HuGE) Navigator: LHX3 (2 documents)

    Export disorders for LHX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LHX3 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with LHX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties. (PubMed id 10598593)1, 2, 3, 9 Sloop K.W....Rhodes S.J. (1999)
    2. Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor. (PubMed id 15517599)1, 2, 9 Parker G.E....Rhodes S.J. (2005)
    3. Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation. (PubMed id 17327381)1, 2, 9 Pfaeffle R.W....Rhodes S.J. (2007)
    4. Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency. (PubMed id 10835633)1, 2, 9 Netchine I....Amselem S. (2000)
    5. Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9. (PubMed id 10717474)1, 3, 9 Sloop K.W....Rhodes S.J. (2000)
    6. Mutation and gene copy number analyses of six pituita ry transcription factor genes in 71 patients with combined pituitary hormone de ficiency: identification of a single patient with LHX4 deletion. (PubMed id 20534763)1, 4 Dateki S....Ogata T. (2010)
    7. A genome-wide association study in 19 633 Japanese su bjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1, 4 Okada Y....Kamatani N. (2010)
    8. Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. (PubMed id 18407919)1, 9 Rajab A....Dattani M.T. (2008)
    9. Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development. (PubMed id 15567726)1, 9 Sobrier M.L....Amselem S. (2004)
    10. Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency. (PubMed id 16394081)1, 9 Bhangoo A.P....Rhodes S.J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8022 HGNC: 6595 AceView: LHX3 Ensembl:ENSG00000107187 euGenes: HUgn8022
    ECgene: LHX3 H-InvDB: LHX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LHX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LHX3 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LHX3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LHX3 gene:
    Search GeneIP for patents involving LHX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LHX3   OriGene RNAi products in human, mouse, rat for LHX3  
     OriGene qPCR primer pairs and template standards for LHX3   OriGene Protein Over-expression Lysate for LHX3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LHX3  
     OriGene qSTAR qPCR primer pairs in human, mouse for LHX3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LHX3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LHX3   OriGene Custom Protein Services for LHX3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LHX3
     QIAGEN SeqTarget long-range PCR primers for resequencing LHX3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX3
     GenScript Custom Purified and Recombinant Proteins Services for LHX3 GenScript cDNA clones with any tag delivered in your preferred vector for LHX3
     GenScript Custom Assay Services for LHX3 GenScript Custom Superior Antibodies Services for LHX3
     GenScript Custom overexpressing Cell Line Services for LHX3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LHX3 promoter
     Search Chromatin IP Primers for LHX3
     RT2 qPCR Primer Assay in human, mouse, rat LHX3
     GNC Network for LHX3
     SABiosciences Custom PCR Arrays for LHX3
     Search Tocris compounds for LHX3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LHX3 antibodies
     LHX3 proteins
     LHX3 lysates
     Antibodies for LHX3
     See all of Abcam's Antibodies, Kits and Proteins for LHX3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for LHX3
     Antibodies for LHX3
     ELISAs for LHX3
     CLIAs for LHX3
     Search LifeMap BioReagents cell lines for LHX3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX3
     SwitchGear 3'UTR luciferase reporter plasmids for LHX3
     SwitchGear Promoter luciferase reporter plasmids for LHX3
     ThermoFisher Antibodies for LHX3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LHX3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LHX3
    Customized:
     lentivirus for stable overexpression of LHX3
     lentivirus expression plasmids for stable overexpression of LHX3
     adenovirus for overexpression of LHX3
     LSBio Antibodies in human, mouse, rat for LHX3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LHX3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4