Aliases for LHX3 Gene
External Ids for LHX3 Gene
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
GeneCards Summary for LHX3 Gene
LHX3 (LIM Homeobox 3) is a Protein Coding gene. Diseases associated with LHX3 include pituitary hormone deficiency, combined, 3 and non-acquired combined pituitary hormone deficiency with spine abnormalities. Among its related pathways are Ca-dependent events. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II transcription factor binding transcription factor activity. An important paralog of this gene is LHX4.
UniProtKB/Swiss-Prot for LHX3 Gene
Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.