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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LHX2 Gene

protein-coding   GIFtS: 60
GCID: GC09P126763

LIM homeobox 2
 Explore 11 diseases affiliated with
LHX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LHX2    

Aliases
for LHX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
LIM Homeobox 21 2     LIM Homeobox Protein 22 3
LH22 3 5     LH-21
HLhx21     LIM HOX Gene 22
Homeobox Protein LH-22 3     LIM/Homeobox Protein Lhx22

External Ids:    HGNC: 65941   Entrez Gene: 93552   Ensembl: ENSG000001066897   OMIM: 6037595   UniProtKB: P504583   

Export aliases for LHX2 gene to outside databases

Previous GC identifers: GC09P117888 GC09P118420 GC09P120227 GC09P122149 GC09P123853 GC09P125813 GC09P126773 GC09P096387


Summaries
for LHX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LHX2:
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique
cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can
recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function
during evolution. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458
Function: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional
regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By
similarity)

Gene Wiki entry for LHX2


Genomic Views
for LHX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LHX2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pbx1a   E2F-2   C/EBPalpha   Max   S8   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LHX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LHX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

LHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P126763:  view genomic region     (about GC identifiers)

Start:
 126,763,949 bp from pter      End:
 126,795,580 bp from pter
Size:
 31,632 bases      Orientation:
 plus strand

Proteins
for LHX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx2  
Size: 406 amino acids; 44373 Da
Subunit: interacts (via LIM domains) with CITED2 (By similarity)
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAC04371.1; Type=Erroneous initiation;
Secondary accessions: O95860 Q52M57 Q8N1Z3

Explore the universe of human proteins at neXtProt for LHX2: NX_P50458

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P50458

    • LHX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004780.3  
    ENSEMBL proteins: 
     ENSP00000453448   ENSP00000362717   ENSP00000394978  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: LHX2
    OriGene Custom Protein Services for LHX2 
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    Novus Biologicals LHX2 Proteins
    Novus Biologicals LHX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LHX2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    LHX2 for ontologies           About GeneDecksing



    LHX2 Antibody Products: 
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    Uscn ELISAs and CLIAs for LHX2

    Protein Domains /
    Families
    for LHX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LHX2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P50458

    ProtoNet protein and cluster: P50458

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458
    Domain: LIM domains are necessary for transcription activation (By similarity)
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    Function
    for LHX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458
    Function: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional
    regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By
    similarity)

         Genatlas biochemistry entry for LHX2:
    putative transcription factor with two LIM and one Hox domain,expressed in chronic myelogenous leukemia,may be
    inactivated by the BCR-ABL translocation

    miRNA
    Products:            		 OriGene 3'-UTR Clone: LHX2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX2 (see all 35):
    hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-890 hsa-miR-124 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: LHX2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX2 (see all 7)
    OriGene shRNA RFP: LHX2
    OriGene siRNA: LHX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LHX2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LHX2 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: LHX2 (NM_004789)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for LHX2
    Search LifeMap BioReagents cell lines for LHX2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000988protein binding transcription factor activity IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    LHX2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for LHX2:
     Decreased Hepatitis C virus re  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for LHX2: Lhx2tm1Dra Lhx2tm1.1Monu Lhx2tm1.2Ddmo
         8 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Lhx2):
     craniofacial  hematopoietic system  homeostasis/metabolism  integument  liver/biliary system 
     mortality/aging  nervous system  vision/eye 

    LHX2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LHX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neural Crest Differentiation
    		Neural Crest Differentiation1.00


    1 BioSystems Pathway for LHX2 
        Neural Crest Differentiation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LHX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/18 Interacting proteins for LHX2 (P504583 ENSP000003627174) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB2O436793, ENSP000003067724I2D: score=3 STRING: ENSP00000306772
    MSX1P283603, ENSP000003721704I2D: score=3 STRING: ENSP00000372170
    LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
    RLIMQ9NVW23, ENSP000002535714I2D: score=1 STRING: ENSP00000253571
    PAX6P263673, ENSP000003684014I2D: score=1 STRING: ENSP00000368401
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007399nervous system development ----
    GO:0007411axon guidance IEA--
    GO:0007420brain development ----


    LHX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LHX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LHX2
    Search CenterWatch for drugs/clinical trials and news about LHX2 

    Transcripts
    for LHX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LHX2 gene: 
    NM_004789.3  

    Unigene Cluster for LHX2:

    LIM homeobox 2
    Hs.696425  [show with all ESTs]
    Unigene Representative Sequence: AK027597
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560961 ENST00000373615(uc004boe.1 uc010mwi.1) ENST00000446480
    ENST00000488674

    miRNA
    Products:             		 OriGene 3'-UTR Clone: LHX2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX2 (see all 35):
    hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-890 hsa-miR-124 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: LHX2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LHX2 (see all 7)
    OriGene shRNA RFP: LHX2
    OriGene siRNA: LHX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHX2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LHX2
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    GenScript: all cDNA clones in your preferred vector: LHX2 (NM_004789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LHX2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHX2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX2

    Additional cDNA sequence: 

    AK027597.1 AK094511.1 BC034458.1 BC093662.1 BC112185.1 

    5 DOTS entries:

    DT.91734002  DT.86846585  DT.100000723  DT.121184052  DT.95369752 

    24/36 AceView cDNA sequences (see all 36):

    BC034458 AI200248 AW949522 AW297230 AI885630 AI570565 NM_004789 AI879746 
    BM718772 AI870435 BI823122 AW055373 BE255549 AK027597 C14677 BU742416 
    AI650535 AI417997 AK094511 AI563896 BG151556 BX283508 AW292511 BM806525 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LHX2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
    SP1:                          -                                   -         
    SP2:                                                              -         
    SP3:                          -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for LHX2

    Expression
    for LHX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LHX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCCTCACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LHX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/24 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 24) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeNeuroblastic LayerEarly Retinal Progenitor CellsRetina
    EyeNeuroblastic LayerLate Retinal Progenitor CellsRetina
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    EyeInner Nuclear LayerMature Muller Glia CellsMuller Glia, Retina
    EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor CellsRetinal Pigmented Epithelium
    LimbAutopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    Floating neuronal aggregates (Generation of choroi...)
    Retinal progenitor-like cells (Generation of retina...)
    Retinal pigment epithelium-like cells (Generation of retina...)
    Neural rosettes (Generation of photor...)
    Rx-GFP+ cells (Generation of retina...)
    Motor neuron-like cells (Generation of motor ...)
    N2-induced embryoid bodies (Generation of photor...)
    N2/LSB induced-cells (Generation of midbra...)
    Dorsal forebrain-like neurons (Generation of midbra...)Brain
    N2/LSB/S/F8-induced cells (Generation of midbra...)

    See LHX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LHX2

    SOURCE GeneReport for Unigene cluster: Hs.696425
        SABiosciences Custom PCR Arrays for LHX2
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX2

    Orthologs
    for LHX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LHX2 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LHX21 LIM homeobox 2 78.28(n)
    90.98(a)    		   395705  NM_204889.1  NP_990220.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii lhx2b1 LIM homeobox 2b 75.36(n)
    86.08(a)    		   791744  NM_001040010.3  NP_001035099.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ap1 , 3 axon guidance specific RNA polymerase II
    transcription more3
    apterous1    		 45(a)3
    57.83(n)1
    53.02(a)1    		   2 41F83
    355091  NM_001169587.11  NP_001163058.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ttx-31 Protein TTX-3 41.78(n)
    38.33(a)    		   181357  NM_077569.4  NP_509970.1 


    ENSEMBL Gene Tree for LHX2 (if available)
    TreeFam Gene Tree for LHX2 (if available) 

    Paralogs
    for LHX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LHX2 gene
    LMO22  ISL12  LHX92  LMX1B2  LMO12  LHX52  LMO42  LHX62  
    LHX12  LMX1A2  LMO32  LHX42  LHX32  LHX82  ISL22  
    18/23 SIMAP similar genes for LHX2 using alignment to 3 protein entries:     LHX2_HUMAN (see all proteins) (see all similar genes):
    LHX9    LHx4    LHX4    LHX3    LMO4    LMX1B
    ISL2    LMO1    ABLIM1    ABLIM2    LMO3    LIMK1
    ISL1    LHX1    LHX6    LDB3    DKFZp686P2249    LHX5

    LHX2 for paralogs           About GeneDecksing



    Genomic Variants
    for LHX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/403 NCBI SNPs in LHX2 are shown (see all 403)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs774115511,2
    		F,--96385657(+) CGTGTA/GGGCGT 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs20415461,2
    		C,--96385674(-) GGCGCG/TCAGGC 1 -- us2k16Minor allele frequency- T:0.08NA WA EA 364
    rs727571741,2
    		C,F,--96386011(+) CCAACA/GGAGAT 1 -- us2k13Minor allele frequency- G:0.09WA NA EA 358
    rs782373661,2
    		F,--96386184(+) CCTCAA/GCTCTG 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs342501361,2
    		C,F,H,--96386624(+) AATGTG/ATCTTG 1 -- us2k17Minor allele frequency- A:0.02NA NS 598
    rs803032381,2
    		--96386748(+) CATGCG/AGAGGA 1 -- us2k12Minor allele frequency- A:0.09CSA WA 120
    rs771163761,2
    		F,--96386834(+) TGTAAA/GTGGCA 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs119996611,2
    		H--96386915(+) GAGAGA/TCCGGG 1 -- us2k10--------
    rs70366851,2
    		C,--96387042(+) GCTCTA/GCCGGG 1 -- us2k10--------
    rs70367131,2
    		C,F,H,--96387117(+) CGATGG/TGAAAC 1 -- us2k17Minor allele frequency- T:0.04NS NA 1132

    HapMap Linkage Disequilibrium report for LHX2 (126763949 - 126795580 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for LHX2
         2 Inversions: 37328 0652

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    Disorders / Diseases
    for LHX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LHX2 for disorders           About GeneDecksing

    OMIM gene information: 603759    OMIM disorders: --

    11 diseases for LHX2:    About MalaCards
    schizencephaly    congenital nystagmus    nystagmus    anophthalmia
    liver fibrosis    fibrosis    cerebritis    retinitis
    thyroiditis    leukemia    neuronitis

    1 Novoseek disease relationship for LHX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver fibrosis 34.5 2 15536133 (2)

    Human Genome Epidemiology (HuGE) Navigator: LHX2 (1 document)

    Export disorders for LHX2 gene to outside databases

    Publications
    for LHX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LHX2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with LHX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. (PubMed id 8649822)1, 2, 3, 9 Wu H.-K.... Minden M.D. (1996)
    2. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. (PubMed id 10051612)1, 2, 3 Rincon-Limas D.E....Botas J. (1999)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins. (PubMed id 11069920)1, 9 Mikkola I....Johansen T. (2001)
    6. Screening of LHX2 in patients presenting growth retard ation with posterior pituitary and ocular abnormalities. (PubMed id 22535646)1 Perez C....Sobrier M.L. (2012)
    7. Mutations in the LHX2 gene are not a frequent cause o f micro/anophthalmia. (PubMed id 21203406)1 Desmaison A....Chassaing N. (2010)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    9. Candidate gene sequencing of LHX2, HESX1, and SOX2 in a large schizencephaly cohort. (PubMed id 20949537)1 Mellado C....Walsh C.A. (2010)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for LHX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LHX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9355 HGNC: 6594 AceView: LHX2 Ensembl:ENSG00000106689 euGenes: HUgn9355
    ECgene: LHX2 H-InvDB: LHX2

    Other Databases showing LHX2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LHX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LHX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LHX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LHX2 gene:
    Search GeneIP for patents involving LHX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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