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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LHX2 Gene

protein-coding   GIFtS: 59
GCID: GC09P126763

LIM Homeobox 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM Homeobox 21 2     hLhx22
LH22 3 5     LIM HOX Gene 22
Homeobox Protein LH-22 3     LIM/Homeobox Protein Lhx22
LIM Homeobox Protein 22 3     

External Ids:    HGNC: 65941   Entrez Gene: 93552   Ensembl: ENSG000001066897   OMIM: 6037595   UniProtKB: P504583   

Export aliases for LHX2 gene to outside databases

Previous GC identifers: GC09P117888 GC09P118420 GC09P120227 GC09P122149 GC09P123853 GC09P125813 GC09P126773 GC09P096387


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LHX2 Gene:
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique
cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein
can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of
function during evolution. (provided by RefSeq, Jul 2008)

GeneCards Summary for LHX2 Gene: 
LHX2 (LIM homeobox 2) is a protein-coding gene. Diseases associated with LHX2 include schizencephaly, and congenital nystagmus. GO annotations related to this gene include protein binding transcription factor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458
Function: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene.
Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and
neural cell types (By similarity)

Gene Wiki entry for LHX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LHX2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pbx1a   E2F-2   C/EBPalpha   Max   S8   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LHX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

LHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P126763:  view genomic region     (about GC identifiers)

Start:
126,763,949 bp from pter      End:
126,795,580 bp from pter
Size:
31,632 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx2  
Size: 406 amino acids; 44373 Da
Subunit: interacts (via LIM domains) with CITED2 (By similarity)
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAC04371.1; Type=Erroneous initiation;
Secondary accessions: O95860 Q52M57 Q8N1Z3

Explore the universe of human proteins at neXtProt for LHX2: NX_P50458

Explore proteomics data for LHX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P50458

  • LHX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LHX2 Protein Expression
    REFSEQ proteins: NP_004780.3  
    ENSEMBL proteins: 
     ENSP00000453448   ENSP00000362717   ENSP00000394978   ENSP00000476200  

    Human Recombinant Protein Products for LHX2: 
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    Novus Biologicals LHX2 Proteins
    Novus Biologicals LHX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LHX2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    LHX2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P50458

    ProtoNet protein and cluster: P50458

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458
    Domain: LIM domains are necessary for transcription activation (By similarity)
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    LHX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LHX2_HUMAN, P50458
    Function: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene.
    Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and
    neural cell types (By similarity)

         Genatlas biochemistry entry for LHX2:
    putative transcription factor with two LIM and one Hox domain,expressed in chronic myelogenous leukemia,may be
    inactivated by the BCR-ABL translocation

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000988protein binding transcription factor activity ----
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
         
    LHX2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LHX2:
     Decreased Hepatitis C virus re  Synthetic lethal with c-Myc af 

         10 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Lhx2):
     craniofacial  hematopoietic system  homeostasis/metabolism  integument  liver/biliary system 
     mortality/aging  nervous system  respiratory system  taste/olfaction  vision/eye 

    LHX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LHX2: Lhx2tm1Dra Lhx2tm1.1Monu Lhx2tm1.2Ddmo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LHX2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHX2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX2 (see all 35):
    hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-890 hsa-miR-124 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidLHX2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LHX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Neural Crest Differentiation
    Neural Crest Differentiation


    1 BioSystems Pathway for LHX2
        Neural Crest Differentiation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LHX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/18 Interacting proteins for LHX2 (P504583 ENSP000003627174) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB2O436793, ENSP000003067724I2D: score=3 STRING: ENSP00000306772
    MSX1P283603, ENSP000003721704I2D: score=3 STRING: ENSP00000372170
    LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
    RLIMQ9NVW23, ENSP000002535714I2D: score=1 STRING: ENSP00000253571
    PAX6P263673, ENSP000003684014I2D: score=1 STRING: ENSP00000368401
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0007399nervous system development ----

    LHX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LHX2

    Search CenterWatch for drugs/clinical trials and news about LHX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LHX2 gene: 
    NM_004789.3  

    Unigene Cluster for LHX2:

    LIM homeobox 2
    Hs.696425  [show with all ESTs]
    Unigene Representative Sequence: AK027597
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560961 ENST00000373615(uc004boe.1 uc010mwi.1) ENST00000446480
    ENST00000488674
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHX2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate LHX2 (see all 35):
    hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-890 hsa-miR-124 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidLHX2 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX2
    Sirion Biotech Customized lentivirus for stable overexpression of LHX2 
                         Customized lentivirus expression plasmids for stable overexpression of LHX2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHX2

    Additional mRNA sequence: 

    AK027597.1 AK094511.1 BC034458.1 BC093662.1 BC112185.1 

    5 DOTS entries:

    DT.91734002  DT.86846585  DT.100000723  DT.121184052  DT.95369752 

    24/36 AceView cDNA sequences (see all 36):

    BC034458 NM_004789 AW949522 AI885630 AI200248 AW297230 AI570565 BU742416 
    AK094511 C14677 AW292511 BX283508 AI650535 BM718772 AI870435 AI417997 
    AI879746 BE255549 AK027597 BI823122 BG151556 AI563896 AW055373 BM806525 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LHX2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
    SP1:                          -                                   -         
    SP2:                                                              -         
    SP3:                          -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for LHX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LHX2 expression in normal human tissues (normalized intensities)      LHX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCTCACAG
    LHX2 Expression
    About this image


    LHX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 29 entries
             Endothelial Cells Blood Brain Barrier
             Thalamus
             N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             Human Astrocytes   
             Septum   
     
     Eye (Sensory Organs)    fully expand to see all 9 entries
             Early Retinal Progenitor Cells Retinal Neuroblastic Layer
             Retina
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Limb (Muscoskeletal System)    fully expand to see all 7 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             limb/hindlimb   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Telencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 7 entries
             Muscle Progenitor Cells Mandibular Arch Muscles

    See LHX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LHX2

    SOURCE GeneReport for Unigene cluster: Hs.696425
        SABiosciences Custom PCR Arrays for LHX2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LHX2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhx21 , 5 LIM homeobox protein 21, 5 91.79(n)1
    99.01(a)1
      2 (24.31 cM)5
    168701  NM_010710.31  NP_034840.11 
     383392815 
    chicken
    (Gallus gallus)
    Aves LHX21 LIM homeobox 2 78.28(n)
    90.98(a)
      395705  NM_204889.1  NP_990220.1 
    lizard
    (Anolis carolinensis)
    Reptilia LHX26
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL344062.1(67225-74152)
    zebrafish
    (Danio rerio)
    Actinopterygii lhx2b1 LIM homeobox 2b 75.36(n)
    86.08(a)
      791744  NM_001040010.3  NP_001035099.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta ap1 , 3 axon guidance specific RNA polymerase
    II transcription more3
    apterous1
    45(a)3
    57.83(n)1
    53.02(a)1
      2 41F83
    355091  NM_001169587.11  NP_001163058.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ttx-31 Protein TTX-3 41.78(n)
    38.33(a)
      181357  NM_077569.4  NP_509970.1 


    ENSEMBL Gene Tree for LHX2 (if available)
    TreeFam Gene Tree for LHX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LHX2 gene
    ISL12  LMO22  LHX92  LMX1B2  LHX52  LMO12  LHX62  LMO42  
    LHX12  LMX1A2  LMO32  LHX32  LHX42  LHX82  ISL22  
    18/21 SIMAP similar genes for LHX2 using alignment to 3 protein entries:     LHX2_HUMAN (see all proteins) (see all similar genes):
    LHX9    LHx4    LHX4    LHX3    LMO4    ISL2
    LMO1    LHX6    ABLIM1    ABLIM2    LMO3    LIMK1
    LHX8    ISL1    LHX1    DKFZp686P2249    LHX5    PDLIM5

    LHX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/461 SNPs in LHX2 are shown (see all 461)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152578711,2
    --126773779(+) GCCTTC/TCCGGA 1 -- us2k10--------
    rs1125072911,2
    C--126774025(+) CTCCTC/GCTCCT 1 -- ut510--------
    rs1852944941,2
    C--126774279(+) GAAGCA/CGGGCG 1 -- ut510--------
    rs78681841,2
    C--126774515(+) ccgggG/Tccgcg 1 -- ut51 ese30--------
    rs1162899241,2
    C,F--126774860(+) GGGTGC/TTGGGG 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1149114361,2
    C,F--126774979(+) AGGAGA/GGCGTT 1 -- int11Minor allele frequency- G:0.07WA 118
    rs1897587681,2
    --126775480(+) GCCGCA/GGAGGT 1 -- int10--------
    rs1507315901,2
    --126775488(+) GGTGGA/GGAGCA 1 -- int10--------
    rs788548601,2
    C,F--126775554(+) CCTCTG/AAGCGC 1 -- int11Minor allele frequency- A:0.05WA 118
    rs760192131,2
    C,F--126775881(+) GGAAAG/TCTCTT 1 -- int11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for LHX2 (126763949 - 126795580 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LHX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893830CNV Loss21882294
    nsv825072CNV Gain20364138
    nsv825073CNV Gain20364138
    nsv7435OTHER Inversion18451855
    nsv47OTHER Inversion15895083

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603759    OMIM disorders: --

    6 diseases for LHX2:    About MalaCards
    schizencephaly    congenital nystagmus    cerebritis    retinitis
    thyroiditis    leukemia


    LHX2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for LHX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver fibrosis 34.5 2 15536133 (2)

    Genetic Association Database (GAD): LHX2
    Human Genome Epidemiology (HuGE) Navigator: LHX2 (1 document)

    Export disorders for LHX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LHX2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with LHX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. (PubMed id 8649822)1, 2, 3, 9 Wu H.-K.... Minden M.D. (1996)
    2. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. (PubMed id 10051612)1, 2, 3 Rincon-Limas D.E....Botas J. (1999)
    3. Mutations in the LHX2 gene are not a frequent cause o f micro/anophthalmia. (PubMed id 21203406)1, 4 Desmaison A....Chassaing N. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins. (PubMed id 11069920)1, 9 Mikkola I....Johansen T. (2001)
    7. Screening of LHX2 in patients presenting growth retard ation with posterior pituitary and ocular abnormalities. (PubMed id 22535646)1 Perez C....Sobrier M.L. (2012)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    9. Candidate gene sequencing of LHX2, HESX1, and SOX2 in a large schizencephaly cohort. (PubMed id 20949537)1 Mellado C....Walsh C.A. (2010)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9355 HGNC: 6594 AceView: LHX2 Ensembl:ENSG00000106689 euGenes: HUgn9355
    ECgene: LHX2 H-InvDB: LHX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LHX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LHX2 gene:
    Search GeneIP for patents involving LHX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in LHX2 promoter
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