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Aliases for LHX2 Gene

Aliases for LHX2 Gene

  • LIM Homeobox 2 2 3 5
  • LIM Homeobox Protein 2 3 4
  • Homeobox Protein LH-2 3 4
  • LH2 3 4
  • LIM HOX Gene 2 3
  • HLhx2 3

External Ids for LHX2 Gene

Previous GeneCards Identifiers for LHX2 Gene

  • GC09P117888
  • GC09P118420
  • GC09P120227
  • GC09P122149
  • GC09P123853
  • GC09P125813
  • GC09P126773
  • GC09P096387
  • GC09P126763

Summaries for LHX2 Gene

Entrez Gene Summary for LHX2 Gene

  • This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHX2 Gene

LHX2 (LIM Homeobox 2) is a Protein Coding gene. Diseases associated with LHX2 include bruck syndrome 2 and schizencephaly. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include sequence-specific DNA binding and transcription factor activity, RNA polymerase II transcription factor binding. An important paralog of this gene is LHX4.

UniProtKB/Swiss-Prot for LHX2 Gene

  • Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).

Gene Wiki entry for LHX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHX2 Gene

Genomics for LHX2 Gene

Regulatory Elements for LHX2 Gene

Genomic Location for LHX2 Gene

124,001,670 bp from pter
124,033,301 bp from pter
31,632 bases
Plus strand

Genomic View for LHX2 Gene

Genes around LHX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHX2 Gene

Proteins for LHX2 Gene

  • Protein details for LHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LIM/homeobox protein Lhx2
    Protein Accession:
    Secondary Accessions:
    • O95860
    • Q52M57
    • Q8N1Z3

    Protein attributes for LHX2 Gene

    406 amino acids
    Molecular mass:
    44373 Da
    Quaternary structure:
    • interacts (via LIM domains) with CITED2.
    • Sequence=BAC04371.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LHX2 Gene

Proteomics data for LHX2 Gene at MOPED

Post-translational modifications for LHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHX2 Gene

Antibody Products

No data available for DME Specific Peptides for LHX2 Gene

Domains & Families for LHX2 Gene

Gene Families for LHX2 Gene

Protein Domains for LHX2 Gene

Suggested Antigen Peptide Sequences for LHX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • LIM domains are necessary for transcription activation.
  • LIM domains are necessary for transcription activation.
  • Contains 1 homeobox DNA-binding domain.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with LHX2: view

Function for LHX2 Gene

Molecular function for LHX2 Gene

GENATLAS Biochemistry:
putative transcription factor with two LIM and one Hox domain,expressed in chronic myelogenous leukemia,may be inactivated by the BCR-ABL translocation
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity).

Gene Ontology (GO) - Molecular Function for LHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LHX2: view
genes like me logo Genes that share phenotypes with LHX2: view

Animal Models for LHX2 Gene

MGI Knock Outs for LHX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LHX2

miRNA for LHX2 Gene

miRTarBase miRNAs that target LHX2
Targeted motifs for LHX2 Gene
HOMER Transcription Factor Regulatory Elements motif LHX2
  • Consensus sequence: TAATTAGN Submotif: canonical Cell Type: HFSC GEO ID: GSE48068

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for LHX2 Gene

Localization for LHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHX2 Gene

Subcellular locations from

Jensen Localization Image for LHX2 Gene COMPARTMENTS Subcellular localization image for LHX2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for LHX2 Gene

Pathways & Interactions for LHX2 Gene

SuperPathways for LHX2 Gene

genes like me logo Genes that share pathways with LHX2: view

Pathways by source for LHX2 Gene

1 BioSystems pathway for LHX2 Gene

Gene Ontology (GO) - Biological Process for LHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007399 nervous system development IEA --
GO:0007411 axon guidance IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with LHX2: view

No data available for SIGNOR curated interactions for LHX2 Gene

Drugs & Compounds for LHX2 Gene

No Compound Related Data Available

Transcripts for LHX2 Gene

Unigene Clusters for LHX2 Gene

LIM homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LHX2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: -

Relevant External Links for LHX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LHX2 Gene

mRNA expression in normal human tissues for LHX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHX2 Gene

This gene is overexpressed in Brain - Amygdala (x7.4), Brain - Cortex (x7.0), Brain - Anterior cingulate cortex (BA24) (x6.6), Brain - Frontal Cortex (BA9) (x6.5), Brain - Hippocampus (x6.3), Brain - Caudate (basal ganglia) (x4.9), Brain - Putamen (basal ganglia) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.4).

SOURCE GeneReport for Unigene cluster for LHX2 Gene Hs.696425

genes like me logo Genes that share expression patterns with LHX2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LHX2 Gene

Orthologs for LHX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LHX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LHX2 35
  • 95.81 (n)
  • 99.75 (a)
LHX2 36
  • 92 (a)
(Canis familiaris)
Mammalia LHX2 35
  • 93.99 (n)
  • 99.01 (a)
LHX2 36
  • 100 (a)
(Mus musculus)
Mammalia Lhx2 35
  • 91.79 (n)
  • 99.01 (a)
Lhx2 16
Lhx2 36
  • 99 (a)
(Pan troglodytes)
Mammalia LHX2 35
  • 99.82 (n)
  • 100 (a)
LHX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lhx2 35
  • 91.3 (n)
  • 99.01 (a)
(Monodelphis domestica)
Mammalia LHX2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia LHX2 36
  • 71 (a)
(Gallus gallus)
Aves LHX2 35
  • 77.78 (n)
  • 90.73 (a)
LHX2 36
  • 78 (a)
(Anolis carolinensis)
Reptilia LHX2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lhx2 35
  • 74.62 (n)
  • 87.69 (a)
(Danio rerio)
Actinopterygii lhx2b 35
  • 74.6 (n)
  • 84.81 (a)
lhx2b 36
  • 79 (a)
fruit fly
(Drosophila melanogaster)
Insecta ap 37
  • 45 (a)
ap 35
  • 57.79 (n)
  • 54.32 (a)
ap 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008980 35
  • 57.58 (n)
  • 52.07 (a)
(Caenorhabditis elegans)
Secernentea ttx-3 36
  • 33 (a)
Species with no ortholog for LHX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHX2 Gene

Gene Tree for LHX2 (if available)
Gene Tree for LHX2 (if available)

Paralogs for LHX2 Gene

Paralogs for LHX2 Gene

(19) SIMAP similar genes for LHX2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LHX2: view

Variants for LHX2 Gene

Sequence variations from dbSNP and Humsavar for LHX2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs917782 -- 124,028,387(-) TTCAC(A/G)TGCCT intron-variant
rs917783 -- 124,028,328(-) GAGAA(G/T)CATCA intron-variant
rs917784 -- 124,027,922(-) AGGTG(A/G)AAAAA intron-variant
rs1042486 -- 124,021,154(+) TACCC(C/G)AGCAG reference, synonymous-codon
rs2159792 -- 124,016,542(-) CTTTT(C/T)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHX2 Gene

Variant ID Type Subtype PubMed ID
nsv7435 OTHER Inversion 18451855
nsv825072 CNV Gain 20364138
nsv47 OTHER Inversion 15895083
nsv893830 CNV Loss 21882294
nsv825073 CNV Gain 20364138

Variation tolerance for LHX2 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LHX2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHX2 Gene

Disorders for LHX2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LHX2 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
bruck syndrome 2
  • osteogenesis imperfecta with congenital joint contractures
  • familial schizencephaly
- elite association - COSMIC cancer census association via MalaCards
Search LHX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LHX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LHX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHX2 Gene

Publications for LHX2 Gene

  1. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. (PMID: 8649822) Wu H.-K. … Minden M.D. (Oncogene 1996) 2 3 4 23 67
  2. Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins. (PMID: 11069920) Mikkola I. … Johansen T. (J. Biol. Chem. 2001) 3 23
  3. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. (PMID: 10051612) Rincon-Limas D.E. … Botas J. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3
  4. Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. (PMID: 25456346) Nievergelt C.M. … Baker D.G. (Psychoneuroendocrinology 2015) 3
  5. Lhx2 regulates the development of the forebrain hem system. (PMID: 23307637) Roy A. … Tole S. (Cereb. Cortex 2014) 3

Products for LHX2 Gene

Sources for LHX2 Gene

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