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LHX2 Gene

protein-coding   GIFtS: 56
GCID: GC09P126763

LIM Homeobox 2

  See LHX2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Homeobox 21 2     hLhx22
LH22 3 5     LIM HOX Gene 22
Homeobox Protein LH-22 3     LIM/Homeobox Protein Lhx22
LIM Homeobox Protein 22 3     

External Ids:    HGNC: 65941   Entrez Gene: 93552   Ensembl: ENSG000001066897   OMIM: 6037595   UniProtKB: P504583   

Export aliases for LHX2 gene to outside databases

Previous GC identifers: GC09P117888 GC09P118420 GC09P120227 GC09P122149 GC09P123853 GC09P125813 GC09P126773 GC09P096387


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LHX2 Gene:
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique
cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein
can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of
function during evolution. (provided by RefSeq, Jul 2008)

GeneCards Summary for LHX2 Gene:
LHX2 (LIM homeobox 2) is a protein-coding gene. Diseases associated with LHX2 include schizencephaly. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II transcription factor binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458
Function: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene.
Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and
neural cell types (By similarity)

Gene Wiki entry for LHX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LHX2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pbx1a   E2F-2   C/EBPalpha   Max   S8   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX2 promoter sequence
   Search Chromatin IP Primers for LHX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

LHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P126763:  view genomic region     (about GC identifiers)

Start:
126,763,949 bp from pter      End:
126,795,580 bp from pter
Size:
31,632 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx2  
Size: 406 amino acids; 44373 Da
Subunit: interacts (via LIM domains) with CITED2 (By similarity)
Sequence caution: Sequence=BAC04371.1; Type=Erroneous initiation;
Secondary accessions: O95860 Q52M57 Q8N1Z3

Explore the universe of human proteins at neXtProt for LHX2: NX_P50458

Explore proteomics data for LHX2 at MOPED


See LHX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004780.3  
ENSEMBL proteins: 
 ENSP00000453448   ENSP00000362717   ENSP00000394978   ENSP00000476200  

LHX2 Human Recombinant Protein Products:

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Novus Biologicals LHX2 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for LHX2

 
Search eBioscience for Proteins for LHX2 

 
antibodies-online proteins for LHX2 (6 products) 

 
antibodies-online peptides for LHX2

LHX2 Antibody Products:

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ThermoFisher Antibody for LHX2
antibodies-online antibodies for LHX2 (41 products) 

LHX2 Assay Products:

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Cloud-Clone Corp. ELISAs for LHX2
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antibodies-online kits for LHX2 (18 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LIM: Homeoboxes / LIM class

4 InterPro protein domains:
 IPR001781 Znf_LIM
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P50458

ProtoNet protein and cluster: P50458

1 Blocks protein domain: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LHX2_HUMAN, P50458
Domain: LIM domains are necessary for transcription activation (By similarity)
Similarity: Contains 1 homeobox DNA-binding domain
Similarity: Contains 2 LIM zinc-binding domains


Find genes that share domains with LHX2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LHX2_HUMAN, P50458
Function: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene.
Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and
neural cell types (By similarity)

     Genatlas biochemistry entry for LHX2:
putative transcription factor with two LIM and one Hox domain,expressed in chronic myelogenous leukemia,may be
inactivated by the BCR-ABL translocation

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001076RNA polymerase II transcription factor binding transcription factor activity IEA--
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with LHX2           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for LHX2:
 Decreased Hepatitis C virus re  Synthetic lethal with c-Myc af 

     10 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Lhx2):
 craniofacial  hematopoietic system  homeostasis/metabolism  integument  liver/biliary system 
 mortality/aging  nervous system  respiratory system  taste/olfaction  vision/eye 

Find genes that share phenotypes with LHX2           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for LHX2: Lhx2tm1Dra Lhx2tm1.1Monu Lhx2tm1.2Ddmo

   genOway: Develop your customized and physiologically relevant rodent model for LHX2

Transcription Factor Targeting: 
Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                      Consensus sequence:  TAATTAGN 

miRNA
Products:
    
miRTarBase miRNAs that target LHX2:
hsa-mir-124-3p (MIRT022169), hsa-mir-196b-5p (MIRT042689)

Block miRNA regulation of human, mouse, rat LHX2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LHX2 (see all 35):
hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-890 hsa-miR-124 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
SwitchGear 3'UTR luciferase reporter plasmidLHX2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for LHX2
Predesigned siRNA for gene silencing in human, mouse, rat LHX2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for LHX2

Clone
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OriGene clones in human, mouse for LHX2 (see all 6)
OriGene ORF clones in mouse, rat for LHX2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LHX2 (NM_004789)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX2

Cell Line
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GenScript Custom overexpressing Cell Line Services for LHX2
Browse ESI BIO Cell Lines and PureStem Progenitors for LHX2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LHX2_HUMAN, P50458: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

Find genes that share ontologies with LHX2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for LHX2 About    
See pathways by source

SuperPathContained pathways About
1Neural Crest Differentiation
Neural Crest Differentiation


1 BioSystems Pathway for LHX2
    Neural Crest Differentiation


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LHX2
Interactions:

    GeneGlobe Interaction Network for LHX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for LHX2 (P504583 ENSP000003627174) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
InteractantInteraction Details
GeneCardExternal ID(s)
LDB2O436793, ENSP000003067724I2D: score=3 STRING: ENSP00000306772
MSX1P283603, ENSP000003721704I2D: score=3 STRING: ENSP00000372170
LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
JAG2Q9Y2193, ENSP000003281694I2D: score=1 STRING: ENSP00000328169
MFNGO005873, ENSP000003494904I2D: score=1 STRING: ENSP00000349490
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Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001843neural tube closure IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0006366transcription from RNA polymerase II promoter ----
GO:0007399nervous system development ----
GO:0007411axon guidance IEA--

Find genes that share ontologies with LHX2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LHX2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for LHX2 gene: 
NM_004789.3  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000560961 ENST00000373615(uc004boe.1 uc010mwi.1) ENST00000446480
ENST00000488674
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat LHX2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LHX2 (see all 35):
hsa-miR-548j hsa-miR-4272 hsa-let-7a-2* hsa-miR-890 hsa-miR-124 hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
SwitchGear 3'UTR luciferase reporter plasmidLHX2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for LHX2
Predesigned siRNA for gene silencing in human, mouse, rat LHX2
Clone
Products:
     
OriGene clones in human, mouse for LHX2 (see all 6)
OriGene ORF clones in mouse, rat for LHX2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LHX2 (NM_004789)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for LHX2
OriGene qSTAR qPCR primer pairs in human, mouse for LHX2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX2
  QuantiTect SYBR Green Assays in human, mouse, rat LHX2
  QuantiFast Probe-based Assays in human, mouse, rat LHX2

Selected AceView cDNA sequences (see all 36):

BC034458 AI200248 AI885630 AW297230 AW949522 AI570565 NM_004789 BE255549 
AW055373 AW292511 AI563896 AI650535 BM718772 AI870435 BI823122 AK027597 
BG151556 AI879746 BU742416 BX283508 AK094511 AI417997 C14677 BF981152 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for LHX2    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1:                          -                                   -         
SP2:                                                              -         
SP3:                          -                                             
SP4:                                                                        


ECgene alternative splicing isoforms for LHX2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LHX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGCCTCACAG
LHX2 Expression
About this image


LHX2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 17) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 7 entries
         Early Retinal Progenitor Cells Retinal Neuroblastic Layer
         Rx-GFP+ cells
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 7 entries
         Muscle Progenitor Cells Mandibular Arch Muscles
 
 Neural Tube (Nervous System)    fully expand to see all 10 entries
         Metencephalon
         Floating neuronal aggregates
 
 NULL (Sensory Organs)    fully expand to see all 2 entries
         Retinal pigment epithelium-like cells
 
 Brain (Nervous System)    fully expand to see all 6 entries
         Endothelial Cells Blood Brain Barrier
         Midbrain tegmentum
         N2/LSB induced-cells
LHX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LHX2 Protein Expression
    Custom PCR Arrays for LHX2
Primer
Products:
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX2
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QuantiFast Probe-based Assays in human, mouse, rat LHX2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LHX2 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lhx21 , 5 LIM homeobox protein 21, 5 91.79(n)1
99.01(a)1
  2 (24.31 cM)5
168701  NM_010710.31  NP_034840.11 
 383392815 
chicken
(Gallus gallus)
Aves LHX21 LIM homeobox 2 77.78(n)
90.73(a)
  395705  NM_204889.1  NP_990220.1 
lizard
(Anolis carolinensis)
Reptilia LHX26
LIM homeobox 2
86(a)
1 ↔ 1
GL344062.1(67225-74152)
tropical clawed frog
(Xenopus tropicalis)
Amphibia lhx21 LIM homeobox 2 74.62(n)
87.69(a)
  100486746  XM_002938749.2  XP_002938795.1 
zebrafish
(Danio rerio)
Actinopterygii lhx2b1 LIM homeobox 2b 74.6(n)
84.81(a)
  791744  NM_001040010.3  NP_001035099.3 
fruit fly
(Drosophila melanogaster)
Insecta ap1 , 3 axon guidance specific RNA polymerase
II transcription more3
apterous1
45(a)3
57.79(n)1
54.32(a)1
  2 41F83
355091  NM_001169587.21  NP_001163058.11 
worm
(Caenorhabditis elegans)
Secernentea ttx-36
Protein TTX-3, isoform a
33(a)
1 → many
X(11764456-11769378) WBGene00006654


ENSEMBL Gene Tree for LHX2 (if available)
TreeFam Gene Tree for LHX2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LHX2 gene
ISL12  LHX92  LMX1B2  LHX52  LHX62  LHX12  LMX1A2  LHX42  
LHX32  LHX82  ISL22  
Selected SIMAP similar genes for LHX2 using alignment to 4 protein entries:     LHX2_HUMAN (see all proteins) (see all similar genes):
LHX9    LHx4    LHX4    LHX3    LMO4    LMO1
ABLIM1    ABLIM2    ISL2    LMO3    LHX1    LHX8
LIMK1    DKFZp686P2249    LHX5    PDLIM5    CDX1    NKX2-5

Find genes that share paralogs with LHX2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LHX2 (see all 461)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1152578711,2
--126773779(+) GCCTTC/TCCGGA 1 -- us2k10--------
rs1125072911,2
C--126774025(+) CTCCTC/GCTCCT 1 -- ut510--------
rs1852944941,2
C--126774279(+) GAAGCA/CGGGCG 1 -- ut510--------
rs78681841,2
C--126774515(+) ccgggG/Tccgcg 1 -- ut51 ese30--------
rs1162899241,2
C,F--126774860(+) GGGTGC/TTGGGG 1 -- int11Minor allele frequency- T:0.05WA 118
rs1149114361,2
C,F--126774979(+) AGGAGA/GGCGTT 1 -- int11Minor allele frequency- G:0.07WA 118
rs1897587681,2
--126775480(+) GCCGCA/GGAGGT 1 -- int10--------
rs1507315901,2
--126775488(+) GGTGGA/GGAGCA 1 -- int10--------
rs788548601,2
C,F--126775554(+) CCTCTG/AAGCGC 1 -- int11Minor allele frequency- A:0.05WA 118
rs760192131,2
C,F--126775881(+) GGAAAG/TCTCTT 1 -- int11Minor allele frequency- T:0.05WA 118

HapMap Linkage Disequilibrium report for LHX2 (126763949 - 126795580 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for LHX2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv893830CNV Loss21882294
nsv825072CNV Gain20364138
nsv825073CNV Gain20364138
nsv7435OTHER Inversion18451855
nsv47OTHER Inversion15895083

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LHX2
DNA2.0 Custom Variant and Variant Library Synthesis for LHX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603759    OMIM disorders: --

1 disease for LHX2:    
About MalaCards
schizencephaly


Find genes that share disorders with LHX2           About GenesLikeMe

1 Novoseek inferred disease relationship for LHX2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
liver fibrosis 34.5 2 15536133 (2)

Genetic Association Database (GAD): LHX2
Human Genome Epidemiology (HuGE) Navigator: LHX2 (1 document)

Export disorders for LHX2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LHX2 gene, integrated from 10 sources (see all 40):
(articles sorted by number of sources associating them with LHX2)
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  1. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. (PubMed id 8649822)1, 2, 3, 9 Wu H.-K.... Minden M.D. (Oncogene 1996)
  2. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. (PubMed id 10051612)1, 2, 3 Rincon-Limas D.E.... Botas J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
  3. Mutations in the LHX2 gene are not a frequent cause of micro/anophthalmia. (PubMed id 21203406)1, 4 Desmaison A....Chassaing N. (Mol. Vis. 2010)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins. (PubMed id 11069920)1, 9 Mikkola I....Johansen T. (J. Biol. Chem. 2001)
  7. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. (PubMed id 23804753)1 Hou P.S....Kuo H.C. (Nucleic Acids Res. 2013)
  8. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. (PubMed id 23966867)1 Liu C.T....Fox C.S. (PLoS Genet. 2013)
  9. Screening of LHX2 in patients presenting growth retardation with posterior pituitary and ocular abnormalities. (PubMed id 22535646)1 PAcrez C....Sobrier M.L. (Eur. J. Endocrinol. 2012)
  10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9355 HGNC: 6594 AceView: LHX2 Ensembl:ENSG00000106689 euGenes: HUgn9355
ECgene: LHX2 H-InvDB: LHX2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for LHX2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LHX2 gene:
Search GeneIP for patents involving LHX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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