Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LHX1 Gene

protein-coding   GIFtS: 59
GCID: GC17P035294

LIM Homeobox 1

  See LHX1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
LIM Homeobox 11 2     LIM Homeobox Protein 12 3
LIM12 3 5     LIM/Homeobox Protein Lhx12
Homeobox Protein Lim-12 3     hLim-13
LIM-12 3     

External Ids:    HGNC: 65931   Entrez Gene: 39752   Ensembl: ENSG000001321307   OMIM: 6019995   UniProtKB: P487423   

Export aliases for LHX1 gene to outside databases

Previous GC identifers: GC17P034678 GC17P037247 GC17P035025 GC17P035490 GC17P032368 GC17P031230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LHX1 Gene:
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich
zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and
urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder
characterized by anomalies in the female genital tract. (provided by RefSeq, Dec 2010)

GeneCards Summary for LHX1 Gene:
LHX1 (LIM homeobox 1) is a protein-coding gene. Diseases associated with LHX1 include mayer-rokitansky-kuster-hauser syndrome, and classic mayer-rokitansky-k??ster-hauser syndrome. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LHX1_HUMAN, P48742
Function: Potential transcription factor. May play a role in early mesoderm formation and later in lateral
mesoderm differentiation and neurogenesis

Gene Wiki entry for LHX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  NT_187614.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the LHX1 gene promoter:
         c-Fos   E2F   AP-1   p53   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHX1 promoter sequence
   Search Chromatin IP Primers for LHX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

LHX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHX1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P035294:  view genomic region     (about GC identifiers)

Start:
35,294,084 bp from pter      End:
35,301,917 bp from pter
Size:
7,834 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LHX1_HUMAN, P48742 (See protein sequence)
Recommended Name: LIM/homeobox protein Lhx1  
Size: 406 amino acids; 44808 Da
Subunit: Interacts with LDB1 via the tandem LIM domains (By similarity)
Secondary accessions: Q3MIW0

Explore the universe of human proteins at neXtProt for LHX1: NX_P48742

Explore proteomics data for LHX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LHX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005559.2  
    ENSEMBL proteins: 
     ENSP00000254457  

    LHX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LHX1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LHX1
    GenScript Custom Purified and Recombinant Proteins Services for LHX1
    Novus Biologicals LHX1 Protein
    Novus Biologicals LHX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LHX1

     
    Search eBioscience for Proteins for LHX1 

     
    antibodies-online proteins for LHX1 (10 products) 

     
    antibodies-online peptides for LHX1

    LHX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LHX1
    R&D Systems Antibodies for LHX1 (LIM1)
    OriGene Antibodies for LHX1
    OriGene Custom Antibody Services for LHX1
    Novus Biologicals LHX1 Antibodies
    Abcam antibodies for LHX1
    Cloud-Clone Corp. Antibodies for LHX1
    ThermoFisher Antibodies for LHX1
    antibodies-online antibodies for LHX1 (44 products) 

    LHX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LHX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LHX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LHX1
    Cloud-Clone Corp. CLIAs for LHX1
    Search eBioscience for ELISAs for LHX1 
    antibodies-online kits for LHX1 (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P48742

    ProtoNet protein and cluster: P48742

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: LHX1_HUMAN, P48742
    Domain: The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an
    activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the
    homeobox (By similarity)
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with LHX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LHX1_HUMAN, P48742
    Function: Potential transcription factor. May play a role in early mesoderm formation and later in lateral
    mesoderm differentiation and neurogenesis

         Genatlas biochemistry entry for LHX1:
    LIM motif containing protein kinase,putative transcription factor,expressed in brain,thymus and tonsillar
    tissue,involved in transcriptional regulation of neural and lymphoid cell

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with LHX1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LHX1:
     Increased circadian period len 

         12 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Lhx1):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size/body  mortality/aging  nervous system  no phenotypic analysis  normal 
     renal/urinary system  reproductive system 

    Find genes that share phenotypes with LHX1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lhx1tm1Bhr for LHX1

       genOway: Develop your customized and physiologically relevant rodent model for LHX1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LHX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LHX1 (see all 81):
    hsa-miR-4272 hsa-miR-1224-3p hsa-miR-485-3p hsa-miR-128 hsa-miR-200a hsa-miR-1260b hsa-miR-30d hsa-miR-138-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LHX1
    Predesigned siRNA for gene silencing in human, mouse, rat LHX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LHX1

    Clone
    Products:
         
    OriGene clones in human, mouse for LHX1 (see all 6)
    OriGene ORF clones in mouse, rat for LHX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LHX1 (NM_005568)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LHX1
    ESI BIO PureStem Progenitors for LHX1: 
    PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem ES-209, Meso-prx/latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA4-14130) for LHX1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LHX1_HUMAN, P48742: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS--
    GO:0043234protein complex ISS--

    Find genes that share ontologies with LHX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LHX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis
    2Neural Crest Differentiation
    Neural Crest Differentiation


    1 BioSystems Pathway for LHX1
        Neural Crest Differentiation


        Pathway & Disease-focused RT2 Profiler PCR Array including LHX1: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LHX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for LHX1 (P487423 ENSP000002544574) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OTX2P322433, ENSP000003438194I2D: score=2 STRING: ENSP00000343819
    ISL1P613713, ENSP000002306584I2D: score=1 STRING: ENSP00000230658
    LDB1Q86U703, ENSP000003924664I2D: score=1 STRING: ENSP00000392466
    LDB2O436793, ENSP000003067724I2D: score=1 STRING: ENSP00000306772
    LHX3Q9UBR43, ENSP000003608114I2D: score=1 STRING: ENSP00000360811
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 71):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001655urogenital system development ISS--
    GO:0001656metanephros development ----
    GO:0001657ureteric bud development ISS--
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001702gastrulation with mouth forming second ISS--

    Find genes that share ontologies with LHX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LHX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LHX1 gene: 
    NM_005568.4  

    Unigene Cluster for LHX1:

    LIM homeobox 1
    Hs.443727  [show with all ESTs]
    Unigene Representative Sequence: NM_005568
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559335 ENST00000254457(uc002hnh.2) ENST00000557970 ENST00000559572(uc010cux.1)
    ENST00000589584
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LHX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LHX1 (see all 81):
    hsa-miR-4272 hsa-miR-1224-3p hsa-miR-485-3p hsa-miR-128 hsa-miR-200a hsa-miR-1260b hsa-miR-30d hsa-miR-138-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LHX1
    Predesigned siRNA for gene silencing in human, mouse, rat LHX1
    Clone
    Products:
         
    OriGene clones in human, mouse for LHX1 (see all 6)
    OriGene ORF clones in mouse, rat for LHX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LHX1 (NM_005568)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LHX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX1
      QuantiTect SYBR Green Assays in human, mouse, rat LHX1
      QuantiFast Probe-based Assays in human, mouse, rat LHX1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA4-14130) for LHX1 

    Additional mRNA sequence: 

    AK298253.1 AK308646.1 BC020470.1 BC036856.1 BC101674.1 BC111936.1 U14755.1 

    4 DOTS entries:

    DT.106597  DT.65286402  DT.40304256  DT.424491 

    Selected AceView cDNA sequences (see all 39):

    AI566122 BF512551 AW516878 AI360476 AW294968 BU734212 AI990607 AI827387 
    BC020470 NM_005568 AW170160 BF115672 AI971941 BE463923 BE876326 BE612590 
    BM541335 AI375565 BE962878 U14755 AW028650 BF507477 AA642714 AI971931 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LHX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGCCGAGG
    LHX1 Expression
    About this image


    LHX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Kidney (Urinary System)    fully expand to see all 20 entries
             Distal Renal Vesicle Cells Renal Vesicle
             Metanephros
             mK4
             Podocalyxin+, CD24+, GCTM2-
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 7 entries
             Intermediate Mesoderm Cells Intermediate Mesoderm
             Mesonephros
             Intermediate mesoderm-like cells
     
     Neurons
             Anterior Latissimus Dorsi Muscle Motor Neurons Caudal Brachial Lateral Motor Division
     
     Spinal Cord (Nervous System)    fully expand to see all 5 entries
             Anterior Latissimus Dorsi Muscle Motor Neurons Caudal Brachial Lateral Motor Division
     
     Epiblast (Early Embryo)    fully expand to see all 7 entries
             Primitive Streak Cells Anterior Primitive Streak
             Epiblast Stem Cell line 5
    LHX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LHX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443727

    UniProtKB/Swiss-Prot: LHX1_HUMAN, P48742
    Tissue specificity: Expressed in the brain, thymus, and tonsils. Expressed in samples from patients with chronic
    myeloid leukemia (CML) and in 58% of acute myeloid leukemia (AML) cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including LHX1: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LHX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX1
    QuantiTect SYBR Green Assays in human, mouse, rat LHX1
    QuantiFast Probe-based Assays in human, mouse, rat LHX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LHX1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhx11 , 5 LIM homeobox protein 11, 5 88.67(n)1
    99.51(a)1
      11 (51.31 cM)5
    168691  NM_008498.21  NP_032524.11 
     845182845 
    chicken
    (Gallus gallus)
    Aves LHX11 LIM homeobox 1 85.88(n)
    94.33(a)
      396381  NM_205413.1  NP_990744.1 
    lizard
    (Anolis carolinensis)
    Reptilia LHX16
    LIM homeobox 1
    93(a)
    1 ↔ 1
    GL343439.1(342210-360702)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.12262 X.laevis Xlim-1 mRNA for LIM domain-containing homeobox more 80.92(n)    X63889.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lhx1a2 LIM homeobox 1a 79.19(n)   30463  L37802.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lim11 , 3 leg disc proximal/distal pattern
    formation transcription more3
    Lim11
    49(a)3
    60.24(n)1
    58.84(a)1
      318131  NM_132277.31  NP_572505.11 
    worm
    (Caenorhabditis elegans)
    Secernentea lin-113 LIM domain containing proteins (2
    domains), homeobox more
    52(a)
    (best of 2)
      I(10256239-10258192)   --


    ENSEMBL Gene Tree for LHX1 (if available)
    TreeFam Gene Tree for LHX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LHX1 gene
    ISL12  LHX22  LHX92  LMX1B2  LHX52  LHX62  LMX1A2  LHX42  
    LHX32  LHX82  ISL22  
    18 SIMAP similar genes for LHX1 using alignment to 2 protein entries:     LHX1_HUMAN (see all proteins):
    LHX5    LHx4    LHX4    LMO1    LHX8    LMO3
    POU6F1    LMO2    LMO4    LHX6    LMX1B    ISL2
    LHX2    ISL1    LHX9    LMX1A    LHX3    FHL1

    Find genes that share paralogs with LHX1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LHX1
    PGOHUM00000262125


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LHX1 (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs771863761,2
    C,F--35292781(+) GGCCAA/CATGAG 1 -- us2k12Minor allele frequency- C:0.16WA EA 238
    rs1452007561,2
    --35292798(+) TAGCAC/TCCCCT 1 -- us2k10--------
    rs1876320731,2
    --35293017(+) AAATAA/GGCCCC 1 -- us2k10--------
    rs782600021,2
    C,F--35293059(+) GCGGGA/CTTAGG 1 -- us2k12Minor allele frequency- C:0.04NA 122
    rs752085821,2
    C,F--35293065(+) TTAGGG/AAGTTA 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs2001192401,2
    --35293234(+) CCCCC-/GCCTCC 1 -- us2k10--------
    rs1140620691,2
    F--35293463(+) GAAACC/TGCCCG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs728261351,2
    C,F--35293520(+) CCCAGG/AACCCG 1 -- us2k11Minor allele frequency- A:0.05NA 120
    rs1921520121,2
    --35293626(+) GATGTA/GCGCTG 1 -- us2k10--------
    rs757980131,2
    C,F--35293652(+) TCCAGG/CTCAAG 1 -- us2k13Minor allele frequency- C:0.08NA WA 240

    HapMap Linkage Disequilibrium report for LHX1 (35294084 - 35301917 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LHX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833430CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): LHX1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LHX1
    DNA2.0 Custom Variant and Variant Library Synthesis for LHX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601999    OMIM disorders: --

    5 diseases for LHX1:    
    About MalaCards
    mayer-rokitansky-kuster-hauser syndrome    classic mayer-rokitansky-k??ster-hauser syndrome    17q12 microdeletion syndrome    murcs association
    nephroblastoma

    1 disease from the University of Copenhagen DISEASES database for LHX1:
    Renal agenesis

    Find genes that share disorders with LHX1           About GenesLikeMe


    Export disorders for LHX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LHX1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with LHX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/homeobox gene, hLim-1. (PubMed id 9212161)1, 2, 3 Dong W.F.... Minden M.D. (DNA Cell Biol. 1997)
    2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Functional genomics identifies drivers of medulloblastoma dissemination. (PubMed id 22875024)1 Mumert M....Fults D.W. (Cancer Res. 2012)
    5. Lim1/LIM1 is expressed in developing and adult mouse and human endometrium. (PubMed id 22231913)1 Ye L....Gargett C.E. (Histochem. Cell Biol. 2012)
    6. LHX1 mutation screening in 96 patients with mA1llerian duct abnormalities. (PubMed id 22217964)1 Xia M....Chen Z.J. (Fertil. Steril. 2012)
    7. Frame shift mutation of LHX1 is associated with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. (PubMed id 22740494)1 Ledig S....Wieacker P. (Hum. Reprod. 2012)
    8. Recurrent aberrations identified by array-CGH in patients with Mayer-Rokitansky-KA1ster-Hauser syndrome. (PubMed id 20797712)1 Ledig S....Wieacker P. (Fertil. Steril. 2011)
    9. LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma. (PubMed id 21132009)1 Dormoy V....Massfelder T. (Oncogene 2011)
    10. Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas. (PubMed id 21778788)1 Guertl B....Hoefler G. (Pathobiology 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3975 HGNC: 6593 AceView: LHX1 Ensembl:ENSG00000132130 euGenes: HUgn3975
    ECgene: LHX1 H-InvDB: LHX1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LHX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LHX1 gene:
    Search GeneIP for patents involving LHX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of LHX1
     
     EMD Millipore genomic analysis products

      
     Antibodies for LHX1 (LIM1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LHX1   OriGene RNAi products in human, mouse, rat for LHX1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for LHX1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LHX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for LHX1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LHX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LHX1   OriGene Custom Protein Services for LHX1  

     
     
     Block miRNA regulation of human, mouse, rat LHX1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LHX1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHX1 Predesigned siRNA for gene silencing in human, mouse, rat LHX1
     QuantiFast Probe-based Assays in human, mouse, rat LHX1 QuantiTect SYBR Green Assays in human, mouse, rat LHX1
     PCR Arrays including human, mouse, rat LHX1 Search Chromatin IP Primers for LHX1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LHX1  GeneGlobe Interaction Network for LHX1
     Regulatory tfbs in LHX1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LHX1 GenScript cDNA clones with any tag delivered in your preferred vector for LHX1
     GenScript Custom Assay Services for LHX1 GenScript Custom overexpressing Cell Line Services for LHX1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LHX1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LHX1 antibodies
     LHX1 proteins
     LHX1 lysates
     Antibodies for LHX1
     See all of Abcam's Antibodies, Kits and Proteins for LHX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LHX1
     Antibodies for LHX1
     ELISAs for LHX1
     CLIAs for LHX1



     PureStem Progenitors for LHX1: PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem ES-209, Meso-prx/latp Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHX1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for LHX1
     SwitchGear Promoter luciferase reporter plasmids for LHX1
     ThermoFisher Antibodies for LHX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHX1
     Browse compounds at ApexBio
     Search Addgene for plasmids for LHX1
      Search eBioscience for proteins for LHX1
      Search eBioscience for elisas for LHX1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for LHX1
     antibodies-online antibodies for LHX1 (44 products)
     antibodies-online kits for LHX1 (20 products)
     antibodies-online peptides for LHX1
     antibodies-online proteins for LHX1 (10 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LHX1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4