Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LHPP Gene

Aliases for LHPP Gene

  • Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase 2 3 5
  • HLHPP 3 4
  • EC 3.1.3.- 4
  • EC 4
  • HDHD2B 3

External Ids for LHPP Gene

Previous GeneCards Identifiers for LHPP Gene

  • GC10P125120
  • GC10P125354
  • GC10P126191
  • GC10P125724
  • GC10P126140
  • GC10P119835

Summaries for LHPP Gene

GeneCards Summary for LHPP Gene

LHPP (Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase) is a Protein Coding gene. Among its related pathways are Purine metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include protein homodimerization activity and inorganic diphosphatase activity. An important paralog of this gene is HDHD2.

UniProtKB/Swiss-Prot for LHPP Gene

  • Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHPP Gene

Genomics for LHPP Gene

Regulatory Elements for LHPP Gene

Enhancers for LHPP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LHPP on UCSC Golden Path with GeneCards custom track

Promoters for LHPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LHPP on UCSC Golden Path with GeneCards custom track

Genomic Location for LHPP Gene

124,461,772 bp from pter
124,617,888 bp from pter
156,117 bases
Plus strand

Genomic View for LHPP Gene

Genes around LHPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHPP Gene

Proteins for LHPP Gene

  • Protein details for LHPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
    Protein Accession:
    Secondary Accessions:
    • B3KP20
    • Q2TBE9
    • Q5VUV9
    • Q5VUW0

    Protein attributes for LHPP Gene

    270 amino acids
    Molecular mass:
    29165 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for LHPP Gene

    Alternative splice isoforms for LHPP Gene


neXtProt entry for LHPP Gene

Proteomics data for LHPP Gene at MOPED

Post-translational modifications for LHPP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHPP Gene

No data available for DME Specific Peptides for LHPP Gene

Domains & Families for LHPP Gene

Gene Families for LHPP Gene

Protein Domains for LHPP Gene

Suggested Antigen Peptide Sequences for LHPP Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily.
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with LHPP: view

Function for LHPP Gene

Molecular function for LHPP Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0 for PNP, and 5.5 for PPi. {ECO:0000269 PubMed:12801912};
UniProtKB/Swiss-Prot CatalyticActivity:
Diphosphate + H(2)O = 2 phosphate.
UniProtKB/Swiss-Prot Function:
Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).

Enzyme Numbers (IUBMB) for LHPP Gene

Gene Ontology (GO) - Molecular Function for LHPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0042803 protein homodimerization activity IPI 12801912
genes like me logo Genes that share ontologies with LHPP: view
genes like me logo Genes that share phenotypes with LHPP: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LHPP Gene

Localization for LHPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHPP Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for LHPP Gene COMPARTMENTS Subcellular localization image for LHPP gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for LHPP Gene

Pathways & Interactions for LHPP Gene

genes like me logo Genes that share pathways with LHPP: view

Pathways by source for LHPP Gene

Gene Ontology (GO) - Biological Process for LHPP Gene


No data available for SIGNOR curated interactions for LHPP Gene

Drugs & Compounds for LHPP Gene

(1) Drugs for LHPP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0

(2) Additional Compounds for LHPP Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with LHPP: view

Transcripts for LHPP Gene

Unigene Clusters for LHPP Gene

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LHPP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: -
SP8: - -

Relevant External Links for LHPP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LHPP Gene

mRNA expression in normal human tissues for LHPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHPP Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.7) and Brain - Substantia nigra (x5.2).

Protein differential expression in normal tissues from HIPED for LHPP Gene

This gene is overexpressed in Salivary gland (7.7) and Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LHPP Gene

SOURCE GeneReport for Unigene cluster for LHPP Gene Hs.527748

mRNA Expression by UniProt/SwissProt for LHPP Gene

Tissue specificity: Expressed in brain, and at lower levels in liver and kidney. Detected in thyroid (at protein level). Expressed in liver, kidney and moderately in brain.
genes like me logo Genes that share expression patterns with LHPP: view

Protein tissue co-expression partners for LHPP Gene

- Elite partner

Primer Products

Orthologs for LHPP Gene

This gene was present in the common ancestor of animals.

Orthologs for LHPP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LHPP 35
  • 88.89 (n)
  • 90.74 (a)
  • 91 (a)
(Canis familiaris)
Mammalia LHPP 35
  • 88.15 (n)
  • 87.04 (a)
  • 87 (a)
(Mus musculus)
Mammalia Lhpp 35
  • 84.44 (n)
  • 88.15 (a)
Lhpp 16
Lhpp 36
  • 88 (a)
(Pan troglodytes)
Mammalia LHPP 35
  • 97.64 (n)
  • 96.23 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Lhpp 35
  • 85.06 (n)
  • 90 (a)
(Monodelphis domestica)
Mammalia LHPP 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia LHPP 36
  • 79 (a)
(Gallus gallus)
Aves LHPP 35
  • 70.2 (n)
  • 68.94 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia LHPP 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lhpp 35
  • 65.38 (n)
  • 68.99 (a)
(Danio rerio)
Actinopterygii lhpp 35
  • 64.36 (n)
  • 64.23 (a)
lhpp 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.364 35
(Caenorhabditis elegans)
Secernentea C13C4.4 37
  • 43 (a)
C13C4.4 35
  • 50.26 (n)
  • 43.25 (a)
C13C4.4 36
  • 41 (a)
Species with no ortholog for LHPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHPP Gene

Gene Tree for LHPP (if available)
Gene Tree for LHPP (if available)

Paralogs for LHPP Gene

Paralogs for LHPP Gene

(1) SIMAP similar genes for LHPP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LHPP: view

Variants for LHPP Gene

Sequence variations from dbSNP and Humsavar for LHPP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs6597801 - 124,484,294(+) GGAGC(A/G)AGGCC nc-transcript-variant, reference, missense
rs1473609 -- 124,460,461(-) AGCTG(C/T)CCCCA upstream-variant-2KB
rs1473610 -- 124,460,367(-) CCCAC(G/T)CTGCA upstream-variant-2KB
rs1533415 -- 124,469,810(-) CTTCC(C/T)GAGTG intron-variant
rs1563274 -- 124,530,121(-) TGCCC(A/G)CCGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHPP Gene

Variant ID Type Subtype PubMed ID
nsv513020 CNV Insertion 21212237
esv1167776 CNV Insertion 17803354
esv1467242 CNV Insertion 17803354
nsv516914 CNV Loss 19592680
nsv896067 CNV Loss 21882294
nsv526655 CNV Loss 19592680
esv2669799 CNV Deletion 23128226
esv22846 CNV Loss 19812545
nsv515761 CNV Loss 19592680
nsv818787 CNV Loss 17921354
nsv525263 CNV Gain 19592680
esv1003661 CNV Insertion 20482838
nsv821023 CNV Deletion 20802225
esv2742672 CNV Deletion 23290073
esv2665311 CNV Deletion 23128226
nsv511460 CNV Gain 21212237
esv2742683 CNV Deletion 23290073
esv1340327 CNV Deletion 17803354
esv2742695 CNV Deletion 23290073
esv2742706 CNV Deletion 23290073
esv1576703 CNV Deletion 17803354
esv2670017 CNV Deletion 23128226
nsv517982 CNV Loss 19592680
dgv832n71 CNV Loss 21882294
nsv896070 CNV Loss 21882294
dgv833n71 CNV Loss 21882294
nsv521161 CNV Gain+Loss 19592680
nsv467470 CNV Loss 19166990
dgv834n71 CNV Loss 21882294
nsv832013 CNV Loss 17160897
nsv467471 CNV Loss 19166990
dgv835n71 CNV Loss 21882294
nsv7589 CNV Insertion 18451855
nsv467473 CNV Loss 19166990
nsv896077 CNV Loss 21882294
esv2742717 CNV Deletion 23290073
esv29125 CNV Loss 19812545
esv1604965 CNV Deletion 17803354
esv2742728 CNV Deletion 23290073
esv5813 CNV Loss 19470904
esv1191959 CNV Insertion 17803354
esv1016617 CNV Insertion 17803354

Variation tolerance for LHPP Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LHPP Gene

Disorders for LHPP Gene

Relevant External Links for LHPP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LHPP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LHPP Gene

Publications for LHPP Gene

  1. Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase. (PMID: 12801912) Yokoi F. … Izuhara K. (J. Biochem. 2003) 2 3 4 23 67
  2. Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism. (PMID: 16430861) Koike E. … Sugihara H. (Biochem. Biophys. Res. Commun. 2006) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3

Products for LHPP Gene

Sources for LHPP Gene