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Aliases for LHFPL4 Gene

Aliases for LHFPL4 Gene

  • LHFPL Tetraspan Subfamily Member 4 2 3 5
  • Lipoma HMGIC Fusion Partner-Like 4 2

External Ids for LHFPL4 Gene

Previous GeneCards Identifiers for LHFPL4 Gene

  • GC07U990146

Summaries for LHFPL4 Gene

Entrez Gene Summary for LHFPL4 Gene

  • This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHFPL4 Gene

LHFPL4 (LHFPL Tetraspan Subfamily Member 4) is a Protein Coding gene. An important paralog of this gene is LHFPL3.

Additional gene information for LHFPL4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHFPL4 Gene

Genomics for LHFPL4 Gene

Regulatory Elements for LHFPL4 Gene

Enhancers for LHFPL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H009552 0.8 ENCODE 0.7 +1.5 1451 0.2 SIN3A ZBTB40 ZSCAN9 CHAMP1 ZNF766 CREM ZNF202 ZBTB11 NCOA1 REST BRPF1 SETD5 RAD18 THUMPD3-AS1 GHRLOS LHFPL4 GC03M009538
GH03H009123 0.3 FANTOM5 1.8 +429.8 429766 0.4 SRGAP3 LHFPL4 GC03P009098 SRGAP3-AS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LHFPL4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LHFPL4 Gene

Genomic Locations for LHFPL4 Gene
chr3:9,498,361-9,553,802
(GRCh38/hg38)
Size:
55,442 bases
Orientation:
Minus strand
chr3:9,540,045-9,595,486
(GRCh37/hg19)

Genomic View for LHFPL4 Gene

Genes around LHFPL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHFPL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHFPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHFPL4 Gene

Proteins for LHFPL4 Gene

  • Protein details for LHFPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7J7-LHPL4_HUMAN
    Recommended name:
    Lipoma HMGIC fusion partner-like 4 protein
    Protein Accession:
    Q7Z7J7
    Secondary Accessions:
    • A6NH76
    • Q29RV7

    Protein attributes for LHFPL4 Gene

    Size:
    247 amino acids
    Molecular mass:
    27007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LHFPL4 Gene

Post-translational modifications for LHFPL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHFPL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LHFPL4 Gene

Domains & Families for LHFPL4 Gene

Gene Families for LHFPL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LHFPL4 Gene

Suggested Antigen Peptide Sequences for LHFPL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7J7

UniProtKB/Swiss-Prot:

LHPL4_HUMAN :
  • Belongs to the LHFP family.
Family:
  • Belongs to the LHFP family.
genes like me logo Genes that share domains with LHFPL4: view

Function for LHFPL4 Gene

Molecular function for LHFPL4 Gene

GENATLAS Biochemistry:
lipoma HMGIC (high mobility group I C protein) fusion partner like gene 4

Phenotypes From GWAS Catalog for LHFPL4 Gene

genes like me logo Genes that share phenotypes with LHFPL4: view

Animal Model Products

miRNA for LHFPL4 Gene

miRTarBase miRNAs that target LHFPL4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LHFPL4 Gene

Localization for LHFPL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHFPL4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LHFPL4 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LHFPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LHFPL4: view

Pathways & Interactions for LHFPL4 Gene

SuperPathways for LHFPL4 Gene

No Data Available

Interacting Proteins for LHFPL4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000287585%0d%0a9606.ENSP00000354950%0d%0a9606.ENSP00000239446%0d%0a9606.ENSP00000307234%0d%0a
Selected Interacting proteins: ENSP00000287585 for LHFPL4 Gene via STRING

Gene Ontology (GO) - Biological Process for LHFPL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LHFPL4 Gene

Drugs & Compounds for LHFPL4 Gene

No Compound Related Data Available

Transcripts for LHFPL4 Gene

mRNA/cDNA for LHFPL4 Gene

Unigene Clusters for LHFPL4 Gene

Lipoma HMGIC fusion partner-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LHFPL4 Gene

No ASD Table

Relevant External Links for LHFPL4 Gene

GeneLoc Exon Structure for
LHFPL4
ECgene alternative splicing isoforms for
LHFPL4

Expression for LHFPL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LHFPL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LHFPL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.4), Brain - Cerebellar Hemisphere (x5.1), Brain - Cortex (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Cerebellum (x4.8), and Brain - Hypothalamus (x4.3).

Protein differential expression in normal tissues from HIPED for LHFPL4 Gene

This gene is overexpressed in Fetal Brain (44.0), Retina (12.8), and Frontal cortex (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LHFPL4 Gene



Protein tissue co-expression partners for LHFPL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LHFPL4 Gene:

LHFPL4

SOURCE GeneReport for Unigene cluster for LHFPL4 Gene:

Hs.56782
genes like me logo Genes that share expression patterns with LHFPL4: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LHFPL4 Gene

Orthologs for LHFPL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LHFPL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LHFPL4 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia LHFPL4 33 34
  • 96.63 (n)
cow
(Bos Taurus)
Mammalia LHFPL4 33 34
  • 95.28 (n)
rat
(Rattus norvegicus)
Mammalia Lhfpl4 33
  • 94.2 (n)
mouse
(Mus musculus)
Mammalia Lhfpl4 33 16 34
  • 94.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LHFPL4 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves LHFPL4 33 34
  • 89.38 (n)
lizard
(Anolis carolinensis)
Reptilia LHFPL4 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lhfpl4 33
  • 81.89 (n)
zebrafish
(Danio rerio)
Actinopterygii lhfpl4a 33 34
  • 76.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tmhs 34
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F26D10.11 34
  • 28 (a)
OneToMany
Species where no ortholog for LHFPL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LHFPL4 Gene

ENSEMBL:
Gene Tree for LHFPL4 (if available)
TreeFam:
Gene Tree for LHFPL4 (if available)

Paralogs for LHFPL4 Gene

Paralogs for LHFPL4 Gene

(3) SIMAP similar genes for LHFPL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LHFPL4: view

Variants for LHFPL4 Gene

Sequence variations from dbSNP and Humsavar for LHFPL4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000042706 -- 9,549,611(+) AGAAT(C/T)ACTTG intron-variant, downstream-variant-500B
rs1000068565 -- 9,545,913(+) CAAAT(-/AAAAG)AAAAG intron-variant
rs1000100376 -- 9,555,665(+) GAGCT(C/G)TCATG upstream-variant-2KB
rs1000110960 -- 9,548,400(+) TCCTT(C/G)CTCTC intron-variant
rs1000146090 -- 9,512,147(+) AGGAT(A/G)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHFPL4 Gene

Variant ID Type Subtype PubMed ID
esv21759 CNV loss 19812545
esv2669412 CNV deletion 23128226
esv27971 CNV loss 19812545
esv3429457 CNV insertion 20981092
esv3595238 CNV loss 21293372
nsv834614 CNV gain 17160897
nsv1074568 CNV deletion 25765185
nsv1010768 CNV gain 25217958

Variation tolerance for LHFPL4 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LHFPL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LHFPL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHFPL4 Gene

Disorders for LHFPL4 Gene

Relevant External Links for LHFPL4

Genetic Association Database (GAD)
LHFPL4
Human Genome Epidemiology (HuGE) Navigator
LHFPL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LHFPL4

No disorders were found for LHFPL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LHFPL4 Gene

Publications for LHFPL4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. (PMID: 15905332) Longo-Guess CM … Johnson KR (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for LHFPL4 Gene

Sources for LHFPL4 Gene

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