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Aliases for LHFPL2 Gene

Aliases for LHFPL2 Gene

  • Lipoma HMGIC Fusion Partner-Like 2 2 3 5
  • KIAA0206 4

External Ids for LHFPL2 Gene

Previous GeneCards Identifiers for LHFPL2 Gene

  • GC05M076586
  • GC05M078017
  • GC05M077819
  • GC05M077865
  • GC05M077816
  • GC05M072987
  • GC05M077781

Summaries for LHFPL2 Gene

Entrez Gene Summary for LHFPL2 Gene

  • This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHFPL2 Gene

LHFPL2 (Lipoma HMGIC Fusion Partner-Like 2) is a Protein Coding gene. Diseases associated with LHFPL2 include Lipoma. An important paralog of this gene is LHFPL3.

Gene Wiki entry for LHFPL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHFPL2 Gene

Genomics for LHFPL2 Gene

Regulatory Elements for LHFPL2 Gene

Enhancers for LHFPL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LHFPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LHFPL2 Gene

Chromosome:
5
Start:
78,485,215 bp from pter
End:
78,770,021 bp from pter
Size:
284,807 bases
Orientation:
Minus strand

Genomic View for LHFPL2 Gene

Genes around LHFPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHFPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHFPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHFPL2 Gene

Proteins for LHFPL2 Gene

  • Protein details for LHFPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUX7-LHPL2_HUMAN
    Recommended name:
    Lipoma HMGIC fusion partner-like 2 protein
    Protein Accession:
    Q6ZUX7
    Secondary Accessions:
    • B2RMQ6
    • Q7Z5P0
    • Q92605

    Protein attributes for LHFPL2 Gene

    Size:
    228 amino acids
    Molecular mass:
    24486 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LHFPL2 Gene

Proteomics data for LHFPL2 Gene at MOPED

Post-translational modifications for LHFPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHFPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LHFPL2 Gene

Domains & Families for LHFPL2 Gene

Protein Domains for LHFPL2 Gene

Suggested Antigen Peptide Sequences for LHFPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZUX7

UniProtKB/Swiss-Prot:

LHPL2_HUMAN :
  • Belongs to the LHFP family.
Family:
  • Belongs to the LHFP family.
genes like me logo Genes that share domains with LHFPL2: view

No data available for Gene Families for LHFPL2 Gene

Function for LHFPL2 Gene

Molecular function for LHFPL2 Gene

GENATLAS Biochemistry:
lipoma HMGIC (high mobility group I C protein) fusion partner like gene 2
genes like me logo Genes that share phenotypes with LHFPL2: view

Animal Model Products

miRNA for LHFPL2 Gene

miRTarBase miRNAs that target LHFPL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LHFPL2 Gene

Localization for LHFPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHFPL2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LHFPL2 Gene COMPARTMENTS Subcellular localization image for LHFPL2 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for LHFPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with LHFPL2: view

Pathways & Interactions for LHFPL2 Gene

SuperPathways for LHFPL2 Gene

No Data Available

Interacting Proteins for LHFPL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369702%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000369702 for LHFPL2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for LHFPL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LHFPL2 Gene

Drugs & Compounds for LHFPL2 Gene

No Compound Related Data Available

Transcripts for LHFPL2 Gene

Unigene Clusters for LHFPL2 Gene

Lipoma HMGIC fusion partner-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LHFPL2 Gene

No ASD Table

Relevant External Links for LHFPL2 Gene

GeneLoc Exon Structure for
LHFPL2
ECgene alternative splicing isoforms for
LHFPL2

Expression for LHFPL2 Gene

mRNA expression in normal human tissues for LHFPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LHFPL2 Gene

This gene is overexpressed in Platelet (26.7) and Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for LHFPL2 Gene



SOURCE GeneReport for Unigene cluster for LHFPL2 Gene Hs.79299

mRNA Expression by UniProt/SwissProt for LHFPL2 Gene

Q6ZUX7-LHPL2_HUMAN
Tissue specificity: Expressed in all tissues and cell lines examined except brain and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with LHFPL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for LHFPL2 Gene

Orthologs for LHFPL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LHFPL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LHFPL2 35
  • 88.6 (n)
  • 93.86 (a)
LHFPL2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LHFPL2 35
  • 88.59 (n)
  • 92.39 (a)
LHFPL2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lhfpl2 35
  • 85.44 (n)
  • 86.94 (a)
Lhfpl2 16
Lhfpl2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LHFPL2 35
  • 99.56 (n)
  • 100 (a)
LHFPL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lhfpl2 35
  • 85.91 (n)
  • 87.27 (a)
oppossum
(Monodelphis domestica)
Mammalia LHFPL2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LHFPL2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves LHFPL2 35
  • 78.65 (n)
  • 85.96 (a)
LHFPL2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LHFPL2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lhfpl2 35
  • 74.81 (n)
  • 84.89 (a)
Str.9232 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14573 35
lhfpl2a 35
  • 69.05 (n)
  • 74.55 (a)
lhfpl2a 36
  • 72 (a)
OneToMany
lhfpl2b 36
  • 72 (a)
OneToMany
lhfpl2b 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3770 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for LHFPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LHFPL2 Gene

ENSEMBL:
Gene Tree for LHFPL2 (if available)
TreeFam:
Gene Tree for LHFPL2 (if available)

Paralogs for LHFPL2 Gene

Paralogs for LHFPL2 Gene

genes like me logo Genes that share paralogs with LHFPL2: view

Variants for LHFPL2 Gene

Sequence variations from dbSNP and Humsavar for LHFPL2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2303654 - 78,509,910(-) CAGCT(A/G)TTTTC nc-transcript-variant, reference, missense
rs730781 -- 78,594,394(-) ACAGC(A/G)TATAT intron-variant
rs730782 -- 78,594,276(-) CCTCT(C/T)CCCCT intron-variant
rs751659 -- 78,506,365(-) ATACA(C/T)TCAGG intron-variant
rs876605 -- 78,505,536(+) AAATG(A/G)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHFPL2 Gene

Variant ID Type Subtype PubMed ID
nsv830356 CNV Gain+Loss 17160897
esv2730337 CNV Deletion 23290073
esv2670505 CNV Deletion 23128226
nsv328668 CNV Loss 16902084
nsv4891 CNV Insertion 18451855
esv2730338 CNV Deletion 23290073
esv2730340 CNV Deletion 23290073
esv2233315 CNV Deletion 18987734
esv2730341 CNV Deletion 23290073
esv2730342 CNV Deletion 23290073
esv2730343 CNV Deletion 23290073
esv2673127 CNV Deletion 23128226
nsv528833 CNV Loss 19592680
esv25871 CNV Loss 19812545

Variation tolerance for LHFPL2 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LHFPL2 Gene

Disorders for LHFPL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LHFPL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
lipoma
  • benign lipomatous tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LHFPL2

Genetic Association Database (GAD)
LHFPL2
Human Genome Epidemiology (HuGE) Navigator
LHFPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LHFPL2
genes like me logo Genes that share disorders with LHFPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHFPL2 Gene

Publications for LHFPL2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. (PMID: 10329012) Petit M.M.R. … Van de Ven W.J.M. (Genomics 1999) 2 3
  3. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 3
  4. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin S.G. … Macciardi F. (PLoS ONE 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for LHFPL2 Gene

Sources for LHFPL2 Gene

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