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Aliases for LHFPL2 Gene

Aliases for LHFPL2 Gene

  • Lipoma HMGIC Fusion Partner-Like 2 2 3 5
  • KIAA0206 4

External Ids for LHFPL2 Gene

Previous GeneCards Identifiers for LHFPL2 Gene

  • GC05M076586
  • GC05M078017
  • GC05M077819
  • GC05M077865
  • GC05M077816
  • GC05M072987
  • GC05M077781

Summaries for LHFPL2 Gene

Entrez Gene Summary for LHFPL2 Gene

  • This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHFPL2 Gene

LHFPL2 (Lipoma HMGIC Fusion Partner-Like 2) is a Protein Coding gene. Diseases associated with LHFPL2 include Lipoma. Among its related pathways are Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is LHFPL1.

Gene Wiki entry for LHFPL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHFPL2 Gene

Genomics for LHFPL2 Gene

Regulatory Elements for LHFPL2 Gene

Enhancers for LHFPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F078590 1.7 FANTOM5 Ensembl ENCODE 13.7 +175.3 175279 9.1 ATF1 MLX WRNIP1 ARID4B SIN3A FEZF1 ZNF48 FOS JUNB NCOA1 LHFPL2 SCAMP1 GC05M078588 GC05M078630
GH05F078585 1.3 FANTOM5 Ensembl ENCODE 13.4 +182.8 182782 3.5 ATF1 PKNOX1 ARNT ELK1 GATA2 FOS NCOA1 MBD2 MEF2D SMARCA4 LHFPL2 SCAMP1-AS1 SCAMP1 GC05M078588 PIR51536
GH05F078543 1.8 FANTOM5 Ensembl ENCODE 13.2 +223.1 223105 7.0 PKNOX1 MLX WRNIP1 FOS JUNB MXD4 TBX21 PPARG KAT8 MIER3 LHFPL2 SCAMP1 PIR51536 GC05M078588
GH05F078792 0.9 Ensembl ENCODE 12.3 -22.5 -22481 0.6 PKNOX1 TBX21 SPI1 LHFPL2 GC05P078984
GH05F078798 1.1 Ensembl ENCODE 12.3 -29.3 -29256 1.3 CTCF JUND FOS RAD21 LHFPL2 GC05P078984
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LHFPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LHFPL2 Gene

78,485,215 bp from pter
78,770,021 bp from pter
284,807 bases
Minus strand

Genomic View for LHFPL2 Gene

Genes around LHFPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHFPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHFPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHFPL2 Gene

Proteins for LHFPL2 Gene

  • Protein details for LHFPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lipoma HMGIC fusion partner-like 2 protein
    Protein Accession:
    Secondary Accessions:
    • B2RMQ6
    • Q7Z5P0
    • Q92605

    Protein attributes for LHFPL2 Gene

    228 amino acids
    Molecular mass:
    24486 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LHFPL2 Gene

Post-translational modifications for LHFPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHFPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LHFPL2 Gene

Domains & Families for LHFPL2 Gene

Protein Domains for LHFPL2 Gene

Suggested Antigen Peptide Sequences for LHFPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LHFP family.
  • Belongs to the LHFP family.
genes like me logo Genes that share domains with LHFPL2: view

No data available for Gene Families for LHFPL2 Gene

Function for LHFPL2 Gene

Molecular function for LHFPL2 Gene

GENATLAS Biochemistry:
lipoma HMGIC (high mobility group I C protein) fusion partner like gene 2

Gene Ontology (GO) - Molecular Function for LHFPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with LHFPL2: view
genes like me logo Genes that share phenotypes with LHFPL2: view

Animal Model Products

miRNA for LHFPL2 Gene

miRTarBase miRNAs that target LHFPL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LHFPL2 Gene

Localization for LHFPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHFPL2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LHFPL2 Gene COMPARTMENTS Subcellular localization image for LHFPL2 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for LHFPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LHFPL2: view

Pathways & Interactions for LHFPL2 Gene

genes like me logo Genes that share pathways with LHFPL2: view

Interacting Proteins for LHFPL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6ZUX7-LHPL2_HUMAN ENSP00000369702 for LHFPL2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for LHFPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LHFPL2: view

No data available for SIGNOR curated interactions for LHFPL2 Gene

Transcripts for LHFPL2 Gene

Unigene Clusters for LHFPL2 Gene

Lipoma HMGIC fusion partner-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LHFPL2 Gene

No ASD Table

Relevant External Links for LHFPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LHFPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LHFPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LHFPL2 Gene

This gene is overexpressed in Platelet (26.7) and Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LHFPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LHFPL2 Gene:


SOURCE GeneReport for Unigene cluster for LHFPL2 Gene:


mRNA Expression by UniProt/SwissProt for LHFPL2 Gene:

Tissue specificity: Expressed in all tissues and cell lines examined except brain and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with LHFPL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for LHFPL2 Gene

Orthologs for LHFPL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LHFPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LHFPL2 34 35
  • 99.56 (n)
(Bos Taurus)
Mammalia LHFPL2 34 35
  • 88.6 (n)
(Canis familiaris)
Mammalia LHFPL2 34 35
  • 88.59 (n)
(Monodelphis domestica)
Mammalia LHFPL2 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia LHFPL2 35
  • 86 (a)
(Rattus norvegicus)
Mammalia Lhfpl2 34
  • 85.91 (n)
(Mus musculus)
Mammalia Lhfpl2 34 16 35
  • 85.44 (n)
(Gallus gallus)
Aves LHFPL2 34 35
  • 78.65 (n)
(Anolis carolinensis)
Reptilia LHFPL2 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lhfpl2 34
  • 74.81 (n)
Str.9232 34
(Danio rerio)
Actinopterygii lhfpl2b 35 35
  • 72 (a)
lhfpl2a 34 35
  • 69.05 (n)
Dr.14573 34
fruit fly
(Drosophila melanogaster)
Insecta CG3770 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
Species where no ortholog for LHFPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LHFPL2 Gene

Gene Tree for LHFPL2 (if available)
Gene Tree for LHFPL2 (if available)

Paralogs for LHFPL2 Gene

Paralogs for LHFPL2 Gene

genes like me logo Genes that share paralogs with LHFPL2: view

Variants for LHFPL2 Gene

Sequence variations from dbSNP and Humsavar for LHFPL2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035651 -- 78,541,914(+) TTAAG(C/T)TACAT intron-variant
rs10036773 -- 78,553,807(+) TACCG(G/T)AATTT intron-variant
rs10037240 -- 78,624,360(+) CTGTG(C/T)TCTCT intron-variant
rs10037983 -- 78,625,376(+) AGTCA(C/T)CTTGA intron-variant
rs10043027 -- 78,496,884(+) TCCTC(C/T)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHFPL2 Gene

Variant ID Type Subtype PubMed ID
dgv1616e212 CNV loss 25503493
dgv9889n54 CNV loss 21841781
dgv9890n54 CNV gain 21841781
dgv9891n54 CNV loss 21841781
dgv9892n54 CNV gain+loss 21841781
esv2233315 CNV deletion 18987734
esv25871 CNV loss 19812545
esv2670505 CNV deletion 23128226
esv2673127 CNV deletion 23128226
esv2730337 CNV deletion 23290073
esv2730338 CNV deletion 23290073
esv2730340 CNV deletion 23290073
esv2730341 CNV deletion 23290073
esv2730342 CNV deletion 23290073
esv2730343 CNV deletion 23290073
esv2762527 CNV gain 21179565
esv3366369 CNV duplication 20981092
esv3566143 CNV deletion 23714750
esv3566144 CNV deletion 23714750
esv3570210 CNV loss 25503493
esv3570213 CNV loss 25503493
esv3605510 CNV gain 21293372
esv3605511 CNV loss 21293372
nsv1021871 CNV gain 25217958
nsv1074311 CNV deletion 25765185
nsv1147024 CNV deletion 26484159
nsv1151653 CNV duplication 26484159
nsv328668 CNV deletion 16902084
nsv476000 CNV novel sequence insertion 20440878
nsv4891 CNV insertion 18451855
nsv528833 CNV loss 19592680
nsv598701 CNV gain 21841781
nsv598708 CNV gain 21841781
nsv830356 CNV gain+loss 17160897
nsv955883 CNV deletion 24416366
nsv958296 CNV deletion 24416366
nsv968954 CNV duplication 23825009

Variation tolerance for LHFPL2 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LHFPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHFPL2 Gene

Disorders for LHFPL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LHFPL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • lipomatosis, multiple
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LHFPL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LHFPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LHFPL2 Gene

Publications for LHFPL2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin S.G. … Macciardi F. (PLoS ONE 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. (PMID: 10329012) Petit M.M.R. … Van de Ven W.J.M. (Genomics 1999) 2 3 64
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64

Products for LHFPL2 Gene

Sources for LHFPL2 Gene

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