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Aliases for LHFP Gene

Aliases for LHFP Gene

  • Lipoma HMGIC Fusion Partner 2 3 5

External Ids for LHFP Gene

Previous GeneCards Identifiers for LHFP Gene

  • GC13M037903
  • GC13M033903
  • GC13M038853
  • GC13M037715
  • GC13M038815
  • GC13M039917
  • GC13M020717

Summaries for LHFP Gene

Entrez Gene Summary for LHFP Gene

  • This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. This gene is fused to a high-mobility group gene in a translocation-associated lipoma. Mutations in another LHFP-like gene result in deafness in humans and mice. Alternatively spliced transcript variants have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for LHFP Gene

LHFP (Lipoma HMGIC Fusion Partner) is a Protein Coding gene. Diseases associated with LHFP include lipoma and gliosarcoma. An important paralog of this gene is LHFPL3.

Gene Wiki entry for LHFP Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LHFP Gene

Genomics for LHFP Gene

Regulatory Elements for LHFP Gene

Enhancers for LHFP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LHFP on UCSC Golden Path with GeneCards custom track

Promoters for LHFP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LHFP on UCSC Golden Path with GeneCards custom track

Genomic Location for LHFP Gene

Chromosome:
13
Start:
39,342,892 bp from pter
End:
39,603,528 bp from pter
Size:
260,637 bases
Orientation:
Minus strand

Genomic View for LHFP Gene

Genes around LHFP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LHFP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LHFP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LHFP Gene

Proteins for LHFP Gene

  • Protein details for LHFP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y693-LHFP_HUMAN
    Recommended name:
    Lipoma HMGIC fusion partner
    Protein Accession:
    Q9Y693
    Secondary Accessions:
    • B2R7M2
    • Q53FC0
    • Q96SH5

    Protein attributes for LHFP Gene

    Size:
    200 amino acids
    Molecular mass:
    21598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LHFP Gene

Proteomics data for LHFP Gene at MOPED

Post-translational modifications for LHFP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LHFP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LHFP Gene

Domains & Families for LHFP Gene

Protein Domains for LHFP Gene

Suggested Antigen Peptide Sequences for LHFP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y693

UniProtKB/Swiss-Prot:

LHFP_HUMAN :
  • Belongs to the LHFP family.
Family:
  • Belongs to the LHFP family.
genes like me logo Genes that share domains with LHFP: view

No data available for Gene Families for LHFP Gene

Function for LHFP Gene

Molecular function for LHFP Gene

GENATLAS Biochemistry:
lipoma HMGIC (high mobility group I C protein) fusion partner in translocations t(12;13)(q13-q15;q12)
genes like me logo Genes that share phenotypes with LHFP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LHFP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LHFP Gene

Localization for LHFP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LHFP Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LHFP Gene COMPARTMENTS Subcellular localization image for LHFP gene
Compartment Confidence
nucleus 3
plasma membrane 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for LHFP Gene

Pathways & Interactions for LHFP Gene

SuperPathways for LHFP Gene

No Data Available

Interacting Proteins for LHFP Gene

Gene Ontology (GO) - Biological Process for LHFP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LHFP Gene

Drugs & Compounds for LHFP Gene

No Compound Related Data Available

Transcripts for LHFP Gene

mRNA/cDNA for LHFP Gene

Unigene Clusters for LHFP Gene

Lipoma HMGIC fusion partner:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LHFP Gene

No ASD Table

Relevant External Links for LHFP Gene

GeneLoc Exon Structure for
LHFP
ECgene alternative splicing isoforms for
LHFP

Expression for LHFP Gene

mRNA expression in normal human tissues for LHFP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LHFP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.0), Testis (20.6), and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for LHFP Gene



SOURCE GeneReport for Unigene cluster for LHFP Gene Hs.507798

mRNA Expression by UniProt/SwissProt for LHFP Gene

Q9Y693-LHFP_HUMAN
Tissue specificity: Pancreas, kidney, skeletal muscle, liver, lung brain, heart, colon, small intestine, uterus, testis, prostate, thymus, spleen and placenta.
genes like me logo Genes that share expression patterns with LHFP: view

Protein tissue co-expression partners for LHFP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LHFP Gene

Orthologs for LHFP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LHFP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LHFP 35
  • 90.59 (n)
  • 98.77 (a)
LHFP 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LHFP 35
  • 92.17 (n)
  • 96.5 (a)
LHFP 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lhfp 35
  • 89 (n)
  • 97 (a)
Lhfp 16
Lhfp 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LHFP 35
  • 99.83 (n)
  • 100 (a)
LHFP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lhfp 35
  • 90 (n)
  • 97 (a)
oppossum
(Monodelphis domestica)
Mammalia LHFP 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LHFP 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves LHFP 35
  • 78.67 (n)
  • 86.5 (a)
LHFP 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LHFP 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lhfp 35
  • 74.17 (n)
  • 84.5 (a)
zebrafish
(Danio rerio)
Actinopterygii lhfp 35
  • 74.67 (n)
  • 86 (a)
CABZ01040571.1 36
  • 81 (a)
ManyToMany
lhfp 36
  • 86 (a)
ManyToMany
Species with no ortholog for LHFP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LHFP Gene

ENSEMBL:
Gene Tree for LHFP (if available)
TreeFam:
Gene Tree for LHFP (if available)

Paralogs for LHFP Gene

Paralogs for LHFP Gene

(3) SIMAP similar genes for LHFP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LHFP: view

Variants for LHFP Gene

Sequence variations from dbSNP and Humsavar for LHFP Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2018 -- 39,500,950(+) TCTAC(C/T)TCCAC intron-variant
rs3108 -- 39,555,392(+) TCATG(C/T)GATAG intron-variant
rs8253 -- 39,343,497(-) AAGCA(A/G)GGTAC utr-variant-3-prime
rs626904 -- 39,410,809(+) TTCAC(C/T)ACTTC intron-variant
rs496593 -- 39,380,771(-) tcaca(A/C)ctgtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LHFP Gene

Variant ID Type Subtype PubMed ID
esv996813 CNV Deletion 20482838
esv25053 CNV Gain+Loss 19812545
nsv826624 CNV Loss 20364138
nsv820008 CNV Loss 19587683
nsv511518 CNV Loss 21212237
nsv820588 CNV Deletion 20802225
nsv512313 CNV Loss 21212237
esv2747287 CNV Deletion 23290073
esv988930 CNV Deletion 20482838
esv1412441 CNV Deletion 17803354
nsv64628 CNV Loss 16902084
esv1008099 CNV Loss 20482838
nsv826625 CNV Gain+Loss 20364138
esv995533 CNV Loss 20482838
nsv64358 CNV Insertion 16902084
esv2663956 CNV Deletion 23128226
nsv900008 CNV Loss 21882294
esv22501 CNV Loss 19812545
nsv507693 CNV Insertion 20534489
nsv1011 CNV Loss 18451855
esv2428792 CNV Deletion 19546169
esv2109685 CNV Deletion 18987734
esv4444 CNV Deletion 18987735
esv2659643 CNV Deletion 23128226
dgv8e197 CNV Deletion 19546169
esv2747288 CNV Deletion 23290073
esv7050 CNV Loss 19470904
nsv64485 CNV Loss 16902084
dgv553e1 CNV Complex 17122850
esv2677218 CNV Deletion 23128226
nsv818957 CNV Loss 17921354
esv1482720 CNV Insertion 17803354
esv2421708 CNV Deletion 20811451
esv2666799 CNV Deletion 23128226
nsv517093 CNV Loss 19592680
nsv523936 CNV Loss 19592680

Variation tolerance for LHFP Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LHFP Gene

HapMap Linkage Disequilibrium report
LHFP
Human Gene Mutation Database (HGMD)
LHFP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LHFP Gene

Disorders for LHFP Gene

MalaCards: The human disease database

(3) MalaCards diseases for LHFP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lipoma
  • benign lipomatous tumor
gliosarcoma
  • glioblastoma with sarcomatous component
chondroma
  • central chondroma
- elite association - COSMIC cancer census association via MalaCards
Search LHFP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LHFP_HUMAN
  • Note=A chromosomal aberration involving LHFP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(12;13)(q13-q15;q12) with HMGA2 is shown in lipomas. {ECO:0000269 PubMed:10329012}.

Relevant External Links for LHFP

Genetic Association Database (GAD)
LHFP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LHFP
genes like me logo Genes that share disorders with LHFP: view

No data available for Genatlas for LHFP Gene

Publications for LHFP Gene

  1. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. (PMID: 10329012) Petit M.M.R. … Van de Ven W.J.M. (Genomics 1999) 2 3 4 23 67
  2. Genome-Wide Association Study of Pre-Eclampsia Detects Novel Maternal Single Nucleotide Polymorphisms and Copy-Number Variants in Subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort. (PMID: 23551011) Zhao L. … Dewan A.T. (Ann. Hum. Genet. 2013) 3
  3. Amplification of the STOML3, FREM2, and LHFP genes is associated with mesenchymal differentiation in gliosarcoma. (PMID: 22538188) Nagaishi M. … Ohgaki H. (Am. J. Pathol. 2012) 3
  4. Multiple loci influencing hippocampal degeneration identified by genome scan. (PMID: 22745009) Melville S.A. … Farrer L.A. (Ann. Neurol. 2012) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for LHFP Gene

Sources for LHFP Gene

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