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LHCGR Gene

protein-coding GIFtS: 65

GC02M048825

luteinizing hormone/choriogonadotropin receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ41504 ^²
LCGR ^¹, ², ³, ⁵
LGR2 ^¹, ², ³
LH/CG-R ^², ³
LH/CGR ^²
LHR ^¹, ², ³, ⁵
LHRHR ^², ³
LSH-R ^², ³

Descriptions
Luteinizing hormone receptor ^³
luteinising hormone-choriogonadotropin receptor ^²
luteinizing hormone/choriogonadotropin receptor ^²
lutropin/choriogonadotropin receptor ^²

External Ids
HGNC: 6585¹
Entrez Gene: 3973²
UniProtKB: P22888³
Ensembl: ENSG00000138039⁷

Search outside databases for aliases for LHCGR gene

Previous GC identifers: GC02M048944 GC02M049082 GC02M048888

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for LHCGR:

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor

belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins

which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary

sexual character development, including familial male precocious puberty, also known as

testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and

male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq]

UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888

Function: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is

mediated by G proteins which activate adenylate cyclase

Gene Wiki entry for LHCGR (Luteinizing_hormone/choriogonadotropin_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LHCGR gene

Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p16.3 HGNC cytogenetic band: 2p21

LHCGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M048825: (about GC identifiers)

Start:	48,767,417 bp from pter
End:	48,836,373 bp from pter
Size:	68,957 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888 (See protein sequence)

Recommended Name: Lutropin-choriogonadotropic hormone receptor precursor

Size: 699 amino acids; 78616 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structure from and Proteopedia :

1LUT (3D)

1XUL (3D)

Secondary accessions: Q14751 Q15996 Q9UEW9

Alternative splicing: 2 isoforms: P22888-1 P22888-2 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000224.2

ENSEMBL proteins:

ENSP00000385847 ENSP00000385406 ENSP00000385288 ENSP00000386033 ENSP00000294954 ENSP00000344301

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (hCG receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005768	endosome	TAS	10617611
GO:0005886	plasma membrane	TAS	10617611
GO:0005887	integral to plasma membrane	TAS	7719343

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Antibodies for LHCGR:

	Invitrogen Antibodies for LHCGR
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LHCGR
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (hCG receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LHCGR)
	Search Novus for antibodies for LHCGR

Assays for LHCGR:

	Invitrogen Assays for LHCGR
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P22888

ProtoNet protein and cluster: P22888

3 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB002131 Glycoprotein hormone receptor signature

IPB002273 Lutropin-choriogonadotropic hormone receptor precursor signature

UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888

Similarity: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily

Similarity: Contains 7 LRR (leucine-rich) repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LHCGR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LHCGR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000233

Applied Biosystems Silencer® siRNAs for LHCGR

Sigma-Aldrich siRNA and siRNA Panels for LHCGR

Sigma-Aldrich shRNA Panels and shRNA for LHCGR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000233
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000233
untagged cDNA clone in CMV expression vector: NM_000233

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000233

UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888

Function: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is

mediated by G proteins which activate adenylate cyclase

Genatlas biochemistry entry for LHCGR:

luteinizing hormone/choriogonadotropin receptor,G protein coupled receptor superfamily,regulating

in males,the devopment and function of Leyding cells with somatic activating mutations leading to

Leyding cell and adenomes of the testis

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lhcgr):

adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	renal/urinary system	reproductive system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004964	lutropin-choriogonadotropic hormone receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for LHCGR

5/34 Interacting proteins for LHCGR (ENSP00000294954³) via UniProtKB, MINT, and/or STRING (see all 34 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CGA	ENSP00000358595³	STRING (score=.998)
LHB	ENSP00000221421³	STRING (score=.988)
ARRB2	ENSP00000370898³	STRING (score=.969)
GIPC1	ENSP00000340698³	STRING (score=.95)
MVK	ENSP00000228510³	STRING (score=.949)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	TAS	7719343
GO:0008584	male gonad development	TAS	7719343
GO:0030539	male genitalia development	TAS	9626653

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LHCGR
10/21 Novoseek chemical compound relationships for LHCGR gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fmpp	89.12	7	11228053 (2), 10704433 (1), 9562960 (1), 16887451 (1) (see all 5)
luteinizing hormone	73.07	3	14982927 (1), 10486313 (1), 9549048 (1)
3beta-hydroxysteroid	54.78	3	10692843 (1), 11356670 (1)
progesterone	54.61	28	11416034 (3), 15117876 (3), 7920181 (2), 18325989 (2) (see all 15)
ribonucleic acid	39.83	2	11238527 (1), 17550979 (1)
leucine	33.96	5	11134146 (1), 9584216 (1), 10215412 (1), 15908694 (1) (see all 5)
steroid	32.22	17	11356670 (2), 11423305 (2), 17709176 (1), 17412805 (1) (see all 8)
mevalonate	30.80	8	14749336 (3), 17550979 (1)
cyclic amp	27.11	1	11394209 (1)
estradiol	24.48	2	11356670 (1), 15117876 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LHCGR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LHCGR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000233

Sigma-Aldrich siRNA and siRNA Panels for LHCGR

Sigma-Aldrich shRNA Panels and shRNA for LHCGR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000233

REFSEQ mRNAs for LHCGR gene:

NM_000233.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000233

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000233
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000233
                                 untagged cDNA clone in CMV expression vector: NM_000233

Additional cDNA sequence:

AK123498.1 M63108.1 M73746.1 S57793.1

3 DOTS entries:

DT.92401909 DT.100840634 DT.75162767

11 AceView cDNA sequences:

S57793 BX097897 BX101581 M63108 NM_000233 AW665653 AI215411 M73746

AI126141 AI004840 AK123498

highest scoring ESTs for LHCGR:

M63108 S57793 AI004840 AI215411 AK123498 BX101581 M73746 NM_000233 AI126141 AL043345

Unigene Cluster for LHCGR:

Luteinizing hormone/choriogonadotropin receptor

Hs.468490 [show with all ESTs]

Unigene Representative Sequence: NM_000233

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000403273 ENST00000401907 ENST00000406114 ENST00000405626 ENST00000294954 ENST00000344775

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LHCGR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LHCGR

¹ / ² / ³

4 probe-sets matching LHCGR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32294_g_at²^{, 3}	U95-A	1	1.00	1.00	0.45	0.22	M63108	1.00	1.00	1.00	1
32293_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M63108	1.00	1.00	1.00	1
207240_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000233	0.60	1.00	0.82	1
207240_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGCTAAATT

SOURCE GeneReport for Unigene cluster: Hs.468490
Expression variation in blood from EXPOLDB for LHCGR
UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888
Tissue specificity: Gonadal and thyroid cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LHCGR gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LHCGR¹	--	luteinizing hormone/choriogonadotropin receptor	89.5(n) 86.99(a)	481365 XM_538486.2 XP_538486.2
cow (Bos taurus)	LHCGR¹	--	luteinizing hormone/choriogonadotropin receptor	88.6(n) 88.17(a)	281900 NM_174381.1 NP_776806.1
rat (Rattus norvegicus)	Lhcgr¹	--	luteinizing hormone/choriogonadotropin receptor	84.11(n) 86.3(a)	25477 NM_012978.1 NP_037110.1
mouse (Mus musculus)	Lhcgr^{1, 5}	17 (46.50 cM)⁵	luteinizing hormone/choriogonadotropin receptor^{1, 5}	84.09(n)¹ 84.54(a)¹	16867¹ NM_013582.2¹ NP_038610.1¹ AK030325⁵ AK054331⁵ (see all 10)
chicken (Gallus gallus)	LHCGR¹	--	luteinizing hormone/choriogonadotropin receptor	72.21(n) 73.65(a)	395776 NM_204936.1 NP_990267.1

About this table Species with no ortholog for LHCGR

ENSEMBL Gene Tree for LHCGR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for LHCGR gene

FSHR² TSHR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/155 NCBI SNPs in LHCGR are shown (see all 155 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 205)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7563126^1,2	A,C,F,H	48837137(+)	`TTTGCG/AATGAG`	1	--	ng3¹		6		EU EA WA NA	594
--	rs7562879^1,2	A,C,F,H	48836899(+)	`GTCCTG/Atatct`	1	--	ng3¹		4		EU EA WA	408
	rs2301267^1,2	A,C,F,H	48837895(-)	`ATATTG/AAGATG`	1	--	ng3¹		4		EU EA WA	418
--	rs7563144^1,2	A,C,F,H	48837293(+)	`TTTTAT/CGGTAA`	1	--	ng3¹		4		EU EA WA	410
	rs2301266^1,2	A,C,F	48838077(-)	`ACTTTT/ATACAT`	1	--	ng3¹		3		EA	1660
--	rs7563465^1,2	A,C	48837433(+)	`GCTTTA/GAAGAG`	1	--	ng3¹ trp³		0	--	--	--	--
	rs11681101^1,2	A,C	48837321(+)	`ATCCCC/TTCTTT`	1	--	ng3¹ trp³		0	--	--	--	--
--	rs10176989^1,2	C	48836372(+)	`TGCGGA/CCCGCA`	1	--	ut5¹		0	--	--	--	--
	rs11686951^1,2	C	48837342(+)	`TTTCTC/TCCTTC`	1	--	ng3¹ trp³		0	--	--	--	--
	rs4952924^1,2	A,C,F,H	48816317(+)	`AGTTGG/TGTTAC`	1	--	int¹		8		EU EA WA NA	630

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HapMap Linkage Disequilibrium images for LHCGR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 152790 disorders: 176410 238320 238320 238320 176410

UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888

Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also

known as testotoxicosis. In FMPP the receptor is constitutively activated

Defects in LHCGR are a cause of Leydig cell hypoplasia (LCH) [MIM:152790]. LCH is an

autosomal recessive disease characterized by male pseudohermaphroditism. In LCH the testes are

small with marked immaturity of the Leydig cells which correlates with undetectable plasma

testosterone levels and elevated gonadotropins

10/30 Novoseek disease relationships for LHCGR gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
precocious puberty, male-limited	94.00	20	7892197 (3), 11134146 (2), 8607787 (1), 8943222 (1) (see all 14)
puberty precocious	82.32	36	9661624 (4), 11134146 (2), 12408104 (2), 9169417 (1) (see all 25)
pseudohermaphroditism male	79.47	8	10704433 (1), 16433250 (1), 9626144 (1), 15719037 (1) (see all 8)
leydig cell tumor	71.82	9	11823449 (1), 12933660 (1), 11861529 (1), 12150333 (1) (see all 6)
primary amenorrhea	65.78	3	10704433 (1), 9626144 (1), 10714363 (1)
ovarian dysgenesis	65.63	1	9562960 (1)
pseudohermaphroditism	65.24	1	11145748 (1)
hypogonadism male	62.72	2	10704433 (1), 18508780 (1)
adrenal tumor	61.71	8	9626655 (2), 14666170 (2), 18509010 (1), 19131502 (1)
micropenis	59.35	1	9238276 (1)

About this table

Human Gene Mutation Database: LHCGR
Genetic Association Database: LHCGR
Human Genome Epidemiology Navigator: LHCGR (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/319 PubMed articles for LHCGR gene (see all 319 ):

A missense (T577I) mutation in the luteinizing hormone receptor gene associated with familial male-limited precocious puberty. (PubMed id 8829636)^{3, 4, 6} Cocco S.... Moi P. (1996)
A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters. (PubMed id 9626144)^{1, 3, 4} Stavrou S.S.... Imperato-Mcginley J. (1998)
A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty. (PubMed id 9661624)^{1, 3, 4} Latronico A.C.... Mendonca B.B. (1998)
Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processing. (PubMed id 15539429)^{1, 3, 4} Munshi U.M.... Menon K.M. (2005)
A homozygous mutation in the luteinizing hormone receptor causes partial Leydig cell hypoplasia: correlation between receptor activity and phenotype. (PubMed id 9626653)^{1, 3, 4} Martens J.W.... Themmen A.P. (1998)
Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. (PubMed id 10580072)^{1, 3, 4} Liu G.... Shenker A. (1999)
Polymorphisms in the coding exons of the human luteinizing hormone receptor gene. (PubMed id 10215412)^{1, 3, 4} Wu S.-M.... Chan W.-Y. (1998)
Comparison of immunocytochemical and molecular features with the phenotype in a case of incomplete male pseudohermaphroditism associated with a mutation of the luteinizing hormone receptor. (PubMed id 9215288)^{1, 3, 4} Misrahi M.... Bougneres P. (1997)
Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty. (PubMed id 7757065)^{1, 3, 4} Kosugi S.... Shenker A. (1995)
A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. (PubMed id 7692306)^{1, 3, 4} Shenker A....Cutler G.B. Jr. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3973	HGNC: 6585	AceView: LHCGR	Ensembl:ENSG00000138039	euGenes: HUgn3973
ECgene: LHCGR	H-InvDB: LHCGR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LHCGR	Genetics and Cytogenetics in Oncology and Haematology
Human luteinizing hormone receptor mutation db	http://www.eur.nl/fgg/endov/lhr.html
GRIS	http://gris.ulb.ac.be/
GeneReviews	http://www.genetests.org/query?gene=LHCGR

Licensable Technologies for LHCGR
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LHCGR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LHCGR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for LHCGR		Antibodies for LHCGR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LHCGR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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LHCGR Gene at Home site.
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LHCGR Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for LHCGR

Summaries
for LHCGR

Genomic Location
for LHCGR

Proteins
for LHCGR

Protein Domains/
Families
for LHCGR

Gene Function
for LHCGR

Pathways & Interactions
for LHCGR

Drugs & Compounds
for LHCGR

Transcripts
for LHCGR

Expression
for LHCGR

Orthologs
for LHCGR

Paralogs
for LHCGR

SNPs/Variants
for LHCGR

Disorders & Mutations
for LHCGR

Medical News
for LHCGR

Publications
for LHCGR

Search for LHCGR

Genome Databases showing LHCGR

Other Databases showing LHCGR

Specialized Databases showing LHCGR

Licensable Technologies
for LHCGR

Services
for LHCGR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LHCGR Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor LHCGR

Summariesfor LHCGR

Genomic Locationfor LHCGR

Proteinsfor LHCGR

Protein Domains/Familiesfor LHCGR

Gene Functionfor LHCGR

Pathways & Interactionsfor LHCGR

Drugs & Compoundsfor LHCGR

Transcriptsfor LHCGR

Expression for LHCGR

Orthologsfor LHCGR

Paralogsfor LHCGR

SNPs/Variantsfor LHCGR

Disorders & Mutationsfor LHCGR

Medical Newsfor LHCGR

Publicationsfor LHCGR

Search for LHCGR

Genome Databases showing LHCGR

Other Databases showing LHCGR

Specialized Databases showing LHCGR

Licensable Technologiesfor LHCGR

Servicesfor LHCGR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LHCGR

Summaries
for LHCGR

Genomic Location
for LHCGR

Proteins
for LHCGR

Protein Domains/
Families
for LHCGR

Gene Function
for LHCGR

Pathways & Interactions
for LHCGR

Drugs & Compounds
for LHCGR

Transcripts
for LHCGR

Expression
for LHCGR

Orthologs
for LHCGR

Paralogs
for LHCGR

SNPs/Variants
for LHCGR

Disorders & Mutations
for LHCGR

Medical News
for LHCGR

Publications
for LHCGR

Licensable Technologies
for LHCGR

Services
for LHCGR