Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LHCGR Gene

protein-coding   GIFtS: 68
GCID: GC02M048825

Luteinizing Hormone/Choriogonadotropin Receptor

(Previous name: hypergonadotropic hypogonadism)
(Previous symbol: HHG)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Luteinizing Hormone/Choriogonadotropin Receptor1 2     LHRHR2 3
LCGR2 3 5     LSH-R2 3
LHR2 3 5     LH/CGR2
HHG1 2     ULG52
Hypergonadotropic Hypogonadism1 2     Lutropin-Choriogonadotropic Hormone Receptor2
LGR22 3     Lutropin/Choriogonadotropin Receptor2
LH/CG-R2 3     Luteinizing Hormone Receptor3

External Ids:    HGNC: 65851   Entrez Gene: 39732   Ensembl: ENSG000001380397   OMIM: 1527905   UniProtKB: P228883   

Export aliases for LHCGR gene to outside databases

Previous GC identifers: GC02M048944 GC02M049082 GC02M048888 GC02M048647


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LHCGR Gene:
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the
G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase.
Mutations in this gene result in disorders of male secondary sexual character development, including familial
male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with
precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. (provided by RefSeq, Jul 2008)

GeneCards Summary for LHCGR Gene: 
LHCGR (luteinizing hormone/choriogonadotropin receptor) is a protein-coding gene. Diseases associated with LHCGR include precocious puberty, and leydig cells hypoplasia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include choriogonadotropin hormone binding and luteinizing hormone receptor activity. An important paralog of this gene is LGR5.

UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888
Function: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G
proteins which activate adenylate cyclase

Gene Wiki entry for LHCGR (Luteinizing hormone/choriogonadotropin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LHCGR gene promoter:
         GR   Sp1   GR-beta   FOXJ2 (long isoform)   GR-alpha   FOXJ2   E4BP4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLHCGR promoter sequence
   Search SABiosciences Chromatin IP Primers for LHCGR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHCGR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p21

LHCGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHCGR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M048825:  view genomic region     (about GC identifiers)

Start:
48,859,428 bp from pter      End:
48,982,880 bp from pter
Size:
123,453 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888 (See protein sequence)
Recommended Name: Lutropin-choriogonadotropic hormone receptor precursor  
Size: 699 amino acids; 78643 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for LHCGR:
1LUT (3D)        1XUL (3D)    
Secondary accessions: Q14751 Q15996 Q9UEW9
Alternative splicing: 2 isoforms:  P22888-1   P22888-2   

Explore the universe of human proteins at neXtProt for LHCGR: NX_P22888

Explore proteomics data for LHCGR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22888

  • LHCGR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LHCGR Protein Expression
    REFSEQ proteins: NP_000224.2  
    ENSEMBL proteins: 
     ENSP00000294954   ENSP00000386033   ENSP00000385847   ENSP00000385406   ENSP00000473498  
     ENSP00000403748   ENSP00000344301  
    Reactome Protein details: P22888
    Human Recombinant Protein Products for LHCGR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for LHCGR
    GenScript Custom Purified and Recombinant Proteins Services for LHCGR
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LHCGR 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome TAS10617611
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane ISS--
    GO:0016021integral to membrane ----

    LHCGR for ontologies           About GeneDecksing



    LHCGR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LHCGR
    OriGene Custom Antibody Services for LHCGR
    GenScript Custom Superior Antibodies Services for LHCGR
    Novus Biologicals LHCGR Antibody
    Abcam antibodies for LHCGR
    Cloud-Clone Corp. Antibodies for LHCGR 
    ThermoFisher Antibodies for LHCGR
    LSBio Antibodies in human, mouse, rat for LHCGR 

    Assay Products for LHCGR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LHCGR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LHCGR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LHCGR 
    Cloud-Clone Corp. CLIAs for LHCGR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GTSHR: GPCR / Class A : Gonadotropin and TSH receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: LH receptor 
    Glycoprotein hormone receptors

    5/6 InterPro protein domains (see all 6):
     IPR002273 LSH_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000372 LRR-contain_N
     IPR002131 Gphrmn_rcpt
     IPR026906 LRR_5

    Graphical View of Domain Structure for InterPro Entry P22888

    ProtoNet protein and cluster: P22888

    3 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB002131 Glycoprotein hormone receptor signature
    IPB002273 Lutropin-choriogonadotropic hormone receptor precursor signature


    UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888
    Similarity: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    LHCGR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LSHR_HUMAN, P22888
    Function: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G
    proteins which activate adenylate cyclase

         Genatlas biochemistry entry for LHCGR:
    luteinizing hormone/choriogonadotropin receptor,G protein coupled receptor superfamily,regulating in males,the
    devopment and function of Leyding cells with somatic activating mutations leading to Leyding cell and adenomes of
    the testis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004964luteinizing hormone receptor activity IEA--
    GO:0035472choriogonadotropin hormone receptor activity ISS--
    GO:0038106choriogonadotropin hormone binding ISS--
         
    LHCGR for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LHCGR:
     Increased circadian period len 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lhcgr):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 
     reproductive system 

    LHCGR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LHCGR: Lhcgrtm1Hht Lhcgrtm1Cvr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LHCGR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LHCGR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHCGR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHCGR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHCGR
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LHCGR:
    hsa-miR-33a* hsa-miR-513a-3p
    SwitchGear 3'UTR luciferase reporter plasmidLHCGR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LHCGR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHCGR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LHCGR
    Sirion Biotech Customized adenovirus for overexpression of LHCGR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LHCGR (see all 4)
    OriGene ORF clones in mouse, rat for LHCGR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LHCGR (NM_000233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHCGR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHCGR
    Sirion Biotech Customized lentivirus for stable overexpression of LHCGR 
                         Customized lentivirus expression plasmids for stable overexpression of LHCGR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LHCGR
    Search LifeMap BioReagents cell lines for LHCGR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHCGR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LHCGR About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Peptide GPCRs0.46
    4Glycoprotein hormones
    Hormone ligand-binding receptors0.33
    5PKA activation in glucagon signalling
    Development Role of Activin A in cell differentiation and proliferation0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for LHCGR
        Development Role of Activin A in cell differentiation and proliferation


    1 GeneGo (Thomson Reuters) Pathway for LHCGR
        Development Role of Activin A in cell differentiation and proliferation

    4 BioSystems Pathways for LHCGR
        Ovarian Infertility Genes
    GPCRs, Class A Rhodopsin-like
    Arf6 signaling events
    Peptide GPCRs

    5/7        Reactome Pathways for LHCGR (see all 7)
        GPCR downstream signaling
    Hormone ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    4         Kegg Pathways  (Kegg details for LHCGR):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Ovarian steroidogenesis
    Prolactin signaling pathway


    LHCGR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LHCGR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/82 Interacting proteins for LHCGR (P228883 ENSP000002949544) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGBP012333, ENSP000003499544I2D: score=1 STRING: ENSP00000349954
    CGB5P012333I2D: score=1 
    CGB7P012333I2D: score=1 
    CGB8P012333I2D: score=1 
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS9626653
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7719343
    GO:0007190activation of adenylate cyclase activity ISS--
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway ISS--

    LHCGR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LHCGR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LHCGR (LSHR)

    6 DrugBank Compounds for LHCGR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lutropin alfaLH-B (see all 5)152923-57-4targetagonist11752352 17016423 17139284 20161981
    MenotropinsLH-B (see all 5)61489-71-2target--17139284 7872378 14680547 17016423
    CetrorelixCetrorelixum [INN-Latin] (see all 3)120287-85-6target--17016423 17139284 11943741
    Choriogonadotropin alfaCG-beta (see all 3)177073-44-8target--15967102 12606382 17059863
    Goserelin-- 65807-02-5targetagonist17139284 20053189 17016423
    Buserelin-- 57982-77-1target--20053189

    4 IUPHAR Ligands for LHCGR (LH receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    hCG
    AgonistFull agonist9.9 - 11.81922095 12727981
    LH
    AgonistFull agonist9.9 - 10.91922095 12727981
    [125I]LH
    AgonistFull agonist9.9 - 10.9--
    [125I]chorionic gonadotropin (human)
    AgonistFull agonist9.9 - 10.9--

    10/41 Novoseek inferred chemical compound relationships for LHCGR gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fmpp 89.1 7 11228053 (2), 10704433 (1), 9562960 (1), 16887451 (1) (see all 5)
    luteinizing hormone 72.1 3 14982927 (1), 10486313 (1), 9549048 (1)
    testosterone 62.6 19 19837924 (4), 14712099 (2), 20173016 (1), 18300940 (1) (see all 13)
    3beta-hydroxysteroid 57 5 10692843 (1), 19541795 (1), 11356670 (1)
    progesterone 55.5 28 11416034 (3), 15117876 (3), 7920181 (2), 18325989 (2) (see all 15)
    ribonucleic acid 42.3 2 11238527 (1), 17550979 (1)
    gnrh 41.6 8 16825187 (2), 17692113 (2), 15216901 (1), 14689055 (1)
    steroid 35.2 18 11356670 (2), 11423305 (2), 20173016 (1), 17709176 (1) (see all 9)
    leuprolide acetate 33.9 1 15216901 (1)
    leucine 32.9 5 11134146 (1), 9584216 (1), 10215412 (1), 15908694 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about LHCGR / LSHR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LHCGR gene: 
    NM_000233.3  

    Unigene Cluster for LHCGR:

    Luteinizing hormone/choriogonadotropin receptor
    Hs.468490  [show with all ESTs]
    Unigene Representative Sequence: NM_000233
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420913 ENST00000294954(uc002rwu.4) ENST00000405626 ENST00000403273
    ENST00000401907(uc002rwv.2) ENST00000602369 ENST00000477576 ENST00000428232
    ENST00000344775

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LHCGR
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LHCGR:
    hsa-miR-33a* hsa-miR-513a-3p
    SwitchGear 3'UTR luciferase reporter plasmidLHCGR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LHCGR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHCGR
    Clone
    Products:
         
    OriGene clones in human, mouse for LHCGR (see all 4)
    OriGene ORF clones in mouse, rat for LHCGR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LHCGR (NM_000233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LHCGR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHCGR
    Sirion Biotech Customized lentivirus for stable overexpression of LHCGR 
                         Customized lentivirus expression plasmids for stable overexpression of LHCGR 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LHCGR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHCGR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHCGR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHCGR

    Additional mRNA sequence: 

    AK123498.1 M63108.1 M73746.1 S57793.1 

    6 DOTS entries:

    DT.92401909  DT.100840634  DT.451942  DT.121363971  DT.75162767  DT.100818328 

    11 AceView cDNA sequences:

    S57793 NM_000233 M63108 BX097897 AW665653 BX101581 M73746 AI215411 
    AI126141 AI004840 AK123498 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LHCGR expression in normal human tissues (normalized intensities)      LHCGR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTAAATT
    LHCGR Expression
    About this image


    LHCGR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Testis (Reproductive System)    fully expand to see all 6 entries
             Testicular Interstitial Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Theca Cells Antral Follicle
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Breast
             breast ; myoepithelial cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in tubules   

    See LHCGR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LHCGR

    SOURCE GeneReport for Unigene cluster: Hs.468490

    UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888
    Tissue specificity: Gonadal and thyroid cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including LHCGR: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LHCGR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LHCGR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHCGR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHCGR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHCGR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LHCGR gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhcgr1 , 5 luteinizing hormone/choriogonadotropin receptor1, 5 84.09(n)1
    84.54(a)1
      17 (58.35 cM)5
    168671  NM_013582.21  NP_038610.11 
     887415495 
    chicken
    (Gallus gallus)
    Aves LHCGR1 luteinizing hormone/choriogonadotropin receptor 72.21(n)
    73.65(a)
      395776  NM_204936.1  NP_990267.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia lhcgr-A2 luteinizing hormone/choriogonadotropin receptor 76.76(n)    AJ249845.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lhcgr1 luteinizing hormone/choriogonadotropin receptor 58.86(n)
    55.97(a)
      402920  NM_205625.1  NP_991188.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fsh1 , 3 G-protein coupled receptor protein
    signaling pathway more3
    Fsh-Tsh-like receptor1
    37(a)
    (best of 2)3
    50.52(n)1
    42.45(a)1
      3 90C23
    421331  NM_079669.21  NP_524393.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C50H2.13
    fshr-11
    steroid hormone receptor3
    Protein FSHR-11
    29(a)3
    46.19(n)1
    32.46(a)1
      V(9892549-9897216)3
    1793811  NM_073147.51  NP_505548.11 


    ENSEMBL Gene Tree for LHCGR (if available)
    TreeFam Gene Tree for LHCGR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LHCGR gene
    LGR52  FSHR2  RXFP12  LGR62  RXFP22  TSHR2  LGR42  
    3 SIMAP similar genes for LHCGR using alignment to 9 protein entries:     LSHR_HUMAN (see all proteins):
    FSHR    TSHR    LGR5

    LHCGR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/66 SNPs in LHCGR are shown (see all 66)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357644
    A breast cancer sample4--see VAR_0357642 D N mis40--------
    VAR_0035624
    Luteinizing hormone resistance (LHR)4--see VAR_0035622 S Y mis40--------
    VAR_0035594
    Familial male precocious puberty (FMPP)4--see VAR_0035592 D G mis40--------
    VAR_0101614
    Familial male precocious puberty (FMPP)4--see VAR_0101612 D E mis40--------
    VAR_0035584
    Familial male precocious puberty (FMPP)4--see VAR_0035582 T I mis40--------
    VAR_0035564
    Familial male precocious puberty (FMPP)4--see VAR_0035562 M I mis40--------
    VAR_0101624
    Leydig cell tumor4--see VAR_0101622 D H mis40--------
    VAR_0101544
    Luteinizing hormone resistance (LHR)4--see VAR_0101542 C R mis40--------
    VAR_0101604
    Familial male precocious puberty (FMPP)4--see VAR_0101602 I L mis40--------
    VAR_0101574
    Familial male precocious puberty (FMPP)4--see VAR_0101572 I L mis40--------

    HapMap Linkage Disequilibrium report for LHCGR (48859428 - 48982880 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LHCGR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv817851CNV Gain17921354
    nsv833992CNV Gain17160897


    Human Gene Mutation Database (HGMD): LHCGR
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing LHCGR
    DNA2.0 Custom Variant and Variant Library Synthesis for LHCGR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 152790   
    OMIM disorders: 176410  238320  
    UniProtKB/Swiss-Prot: LSHR_HUMAN, P22888
  • Familial male precocious puberty (FMPP) [MIM:176410]: In FMPP the receptor is constitutively activated.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Luteinizing hormone resistance (LHR) [MIM:238320]: An autosomal recessive disorder characterized by
    unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular
    development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in
    males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and
    high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones,
    lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form,
    displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 20/41 diseases for LHCGR (see all 41):    About MalaCards
    precocious puberty    leydig cells hypoplasia    familial male-limited precocious puberty    testotoxicosis
    hypogonadism    luteinizing hormone resistance, female    leydig cell hypoplasia/agenesis    leydig cell hypoplasia with pseudohermaphroditism
    leydig cell adenoma, somatic, with precocious puberty    precocious puberty, male    leydig cell hypoplasia with hypergonadotropic hypogonadism    pseudohermaphroditism
    hypogonadotropism    ovarian epithelial cancer    adenoma    amenorrhea
    leiomyomatosis    leydig cell tumor    ovarian hyperstimulation syndrome    cushing's syndrome

    2 diseases from the University of Copenhagen DISEASES database for LHCGR:
    Pseudohermaphroditism     Infertility

    LHCGR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/30 Novoseek inferred disease relationships for LHCGR gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    precocious puberty, male-limited 94.2 21 7892197 (3), 11134146 (2), 8607787 (1), 7593421 (1) (see all 15)
    puberty precocious 81.8 36 9661624 (4), 11134146 (2), 12408104 (2), 9169417 (1) (see all 25)
    pseudohermaphroditism male 80.1 10 19551906 (2), 10704433 (1), 16433250 (1), 9626144 (1) (see all 9)
    leydig cell tumor 71.2 9 11823449 (1), 12933660 (1), 11861529 (1), 12150333 (1) (see all 6)
    ovarian dysgenesis 65 1 9562960 (1)
    primary amenorrhea 64.8 3 10704433 (1), 9626144 (1), 10714363 (1)
    pseudohermaphroditism 64.7 1 11145748 (1)
    hypogonadism male 61.5 2 10704433 (1), 18508780 (1)
    adrenal tumor 60.7 8 9626655 (2), 14666170 (2), 18509010 (1), 19131502 (1)
    hypoplasia 58.3 20 16433250 (2), 9817592 (2), 16709601 (2), 9890061 (1) (see all 15)

    Genetic Association Database (GAD): LHCGR
    Human Genome Epidemiology (HuGE) Navigator: LHCGR (22 documents)

    Export disorders for LHCGR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LHCGR gene, integrated from 9 sources (see all 407):
    (articles sorted by number of sources associating them with LHCGR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset. (PubMed id 12679452)1, 2, 4, 9 Powell B.L....Berns E.M. (2003)
    2. A missense (T577I) mutation in the luteinizing hormone receptor gene associated with familial male-limited precocious puberty. (PubMed id 8829636)1, 2, 4 Cocco S.... Moi P. (1996)
    3. A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters. (PubMed id 9626144)1, 2, 9 Stavrou S.S.... Imperato-Mcginley J. (1998)
    4. A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty. (PubMed id 9661624)1, 2, 9 Latronico A.C.... Mendonca B.B. (1998)
    5. A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditism. (PubMed id 19551906)1, 2, 9 Qiao J.... Song H.-D. (2009)
    6. Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome. (PubMed id 17074323)1, 4, 9 Kerkela E....Hovatta O. (2007)
    7. Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processing. (PubMed id 15539429)1, 2, 9 Munshi U.M.... Menon K.M. (2005)
    8. The lutropin/choriogonadotropin receptor, a 2002 perspective. (PubMed id 11943741)1, 7, 9 Ascoli M....Segaloff D.L. (2002)
    9. GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients. (PubMed id 17692113)1, 4, 9 Piersma D....Berns E.M. (2007)
    10. Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility. (PubMed id 18300940)1, 4, 9 Simoni M....Gromoll J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3973 HGNC: 6585 AceView: LHCGR Ensembl:ENSG00000138039 euGenes: HUgn3973
    ECgene: LHCGR Kegg: 3973 H-InvDB: LHCGR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LHCGR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LHCGR Genetics and Cytogenetics in Oncology and Haematology
    GRIShttp://gris.ulb.ac.be/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LHCGR
    Sequence-structure-function-analysis of glycoprotein hormone receptorshttp://www.ssfa-gphr.de/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LHCGR gene:
    Search GeneIP for patents involving LHCGR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for LHCGR (LHR)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LHCGR   OriGene RNAi products in human, mouse, rat for LHCGR  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LHCGR  
     OriGene qSTAR qPCR primer pairs in human, mouse for LHCGR   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LHCGR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LHCGR   OriGene Custom Protein Services for LHCGR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LHCGR
     QIAGEN SeqTarget long-range PCR primers for resequencing LHCGR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LHCGR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LHCGR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LHCGR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LHCGR
     GenScript Custom Purified and Recombinant Proteins Services for LHCGR GenScript cDNA clones with any tag delivered in your preferred vector for LHCGR
     GenScript Custom Assay Services for LHCGR GenScript Custom Superior Antibodies Services for LHCGR
     GenScript Custom overexpressing Cell Line Services for LHCGR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LHCGR promoter
     Search Chromatin IP Primers for LHCGR
     RT2 qPCR Primer Assay in human, mouse, rat LHCGR
     GNC Network for LHCGR
     SABiosciences PCR Arrays including human, mouse, rat LHCGR
     Search Tocris compounds for LHCGR (LSHR)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LHCGR antibodies
     Antibodies for LHCGR
     See all of Abcam's Antibodies, Kits and Proteins for LHCGR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for LHCGR
     Antibodies for LHCGR
     ELISAs for LHCGR
     CLIAs for LHCGR
     Search LifeMap BioReagents cell lines for LHCGR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHCGR
     SwitchGear 3'UTR luciferase reporter plasmids for LHCGR
     SwitchGear Promoter luciferase reporter plasmids for LHCGR
     ThermoFisher Antibodies for LHCGR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHCGR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LHCGR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LHCGR
    Customized:
     lentivirus for stable overexpression of LHCGR
     lentivirus expression plasmids for stable overexpression of LHCGR
     adenovirus for overexpression of LHCGR
     LSBio Antibodies in human, mouse, rat for LHCGR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LHCGR gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4