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LHB Gene

protein-coding   GIFtS: 57
GCID: GC19M049519

Luteinizing Hormone Beta Polypeptide

  See LHB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Luteinizing Hormone Beta Polypeptide1 2     lutropin1
Luteinizing Hormone Beta Subunit1 2     CGB42
Lutropin Beta Chain2 3     hLHB2
LSH-B2 3     Interstitial Cell Stimulating Hormone, Beta Chain2
LSH-beta2 3     Lutropin Subunit Beta2
Beta Chain1     LH-B3
Interstitial Cell Stimulating Hormone1     Luteinizing Hormone Subunit Beta3

External Ids:    HGNC: 65841   Entrez Gene: 39722   Ensembl: ENSG000001048267   OMIM: 1527805   UniProtKB: P012293   

Export aliases for LHB gene to outside databases

Previous GC identifers: GC19M050177 GC19M049887 GC19M054195 GC19M054211 GC19M045895


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LHB Gene:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing
hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta
subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis
and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of
chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene
are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. (provided by
RefSeq, Jul 2008)

GeneCards Summary for LHB Gene:
LHB (luteinizing hormone beta polypeptide) is a protein-coding gene. Diseases associated with LHB include frozen shoulder, and hypogonadism lhb-related. GO annotations related to this gene include hormone activity and receptor binding. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot: LSHB_HUMAN, P01229
Function: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids

Gene Wiki entry for LHB (Luteinizing hormone beta polypeptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the LHB gene promoter:
         Egr-3   AhR   NF-1   NF-1/L   Pax-5   RREB-1   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for LHB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

LHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LHB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049519:  view genomic region     (about GC identifiers)

Start:
49,519,237 bp from pter      End:
49,520,347 bp from pter
Size:
1,111 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LSHB_HUMAN, P01229 (See protein sequence)
Recommended Name: Lutropin subunit beta precursor  
Size: 141 amino acids; 15345 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
1 PDB 3D structure from and Proteopedia for LHB:
1M92 (3D)    
Secondary accessions: Q9UDI0

Explore the universe of human proteins at neXtProt for LHB: NX_P01229

Explore proteomics data for LHB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn50

  • See LHB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000885.1  
    ENSEMBL proteins: 
     ENSP00000221421  
    Reactome Protein details: P01229

    LHB Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LHB 

    LHB Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for LHB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR006208 Cys_knot
     IPR001545 Gonadotropin_bsu

    Graphical View of Domain Structure for InterPro Entry P01229

    ProtoNet protein and cluster: P01229

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: LSHB_HUMAN, P01229
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    Find genes that share domains with LHB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LSHB_HUMAN, P01229
    Function: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids

         Genatlas biochemistry entry for LHB:
    luteinizing hormone,beta polypeptide (see CGB@),whith a common genetic variant-leading in the heterozygous or
    homozygous type to slight but significant alterations in ovarian steroido genesis,delayed progression of puberty
    in males

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10484773
    GO:0005179hormone activity IEA--
         
    Find genes that share ontologies with LHB           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lhb):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with LHB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lhbtm1Kmr for LHB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LHB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LHB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LHB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LHB

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    1 qRT-PCR Assays for microRNA that regulate LHB:
    hsa-miR-30b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LHB

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LHB

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LSHB_HUMAN, P01229: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with LHB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LHB About   (see all 26)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with LHB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LHB (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for LHB
        Development Role of Activin A in cell differentiation and proliferation

    1 BioSystems Pathway for LHB
        TCR Signaling Pathway

    5 Reactome Pathways for LHB
        Mineralocorticoid biosynthesis
    Hormone ligand-binding receptors
    Androgen biosynthesis
    Glycoprotein hormones
    G alpha (s) signalling events


    4 Kegg Pathways  (Kegg details for LHB):
        Neuroactive ligand-receptor interaction
    GnRH signaling pathway
    Ovarian steroidogenesis
    Prolactin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LHB
    Interactions:

        Search GeneGlobe Interaction Network for LHB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for LHB (P012293 ENSP000002214214) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNASQ5JWF23, ENSP000003601414I2D: score=2 STRING: ENSP00000360141
    LHCGRP228883, ENSP000002949544I2D: score=1 STRING: ENSP00000294954
    CGAP012153, ENSP000003585954I2D: score=1 STRING: ENSP00000358595
    GNAI2P048993, ENSP000003129994I2D: score=2 STRING: ENSP00000312999
    CYP17A1ENSP000003589034STRING: ENSP00000358903
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006701progesterone biosynthetic process TAS14557487
    GO:0007165signal transduction TAS10484773
    GO:0007267cell-cell signaling TAS10484773
    GO:0008584male gonad development TAS6785294
    GO:0016486peptide hormone processing TAS--

    Find genes that share ontologies with LHB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LHB (LSHB)

    1 Novoseek inferred chemical compound relationship for LHB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gnrh 50.1 5 17021348 (2)



    Find genes that share compounds with LHB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LHB gene: 
    NM_000894.2  

    Unigene Cluster for LHB:

    Luteinizing hormone beta polypeptide
    Hs.154704  [show with all ESTs]
    Unigene Representative Sequence: CD556799
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000221421(uc002plt.3)
    miRNA
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    hsa-miR-30b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    6 DOTS entries:

    DT.86959352  DT.119691  DT.100837633  DT.102832971  DT.101971461  DT.95315378 

    Selected AceView cDNA sequences (see all 37):

    NM_000894 AA371912 T29543 AV747923 CD107094 CD512924 AA371346 AA371971 
    BV173480 CD107246 CD105618 AA371978 CD106601 CD107120 AI051683 BV206139 
    CD107665 H95206 AA372026 CD107666 AV745712 AV751144 AV746068 AV748231 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LHB Expression
    About this image

    LHB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LHB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154704

    UniProtKB/Swiss-Prot: LSHB_HUMAN, P01229
    Tissue specificity: Pituitary gland

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LHB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LHB gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lhb1 , 5 luteinizing hormone beta1, 5 78.96(n)1
    71.63(a)1
      7 (29.30 cM)5
    168661  NM_008497.21  NP_032523.21 
     454183535 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    1 → many
    6(80158039-80158659)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004906151 lutropin subunit beta-like 51.82(n)
    37.5(a)
      100490615  XM_002939235.2  XP_002939281.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lhb1 luteinizing hormone, beta polypeptide 54.95(n)
    46.85(a)
      402917  NM_205622.2  NP_991185.1 


    ENSEMBL Gene Tree for LHB (if available)
    TreeFam Gene Tree for LHB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LHB gene
    TSHB2  FSHB2  CGB22  CGB82  ENSG000002673352  CGB52  CGB2  CGB72  
    CGB12  
    8 SIMAP similar genes for LHB using alignment to 3 protein entries:     LSHB_HUMAN (see all proteins):
    CGB    CGB5    CGB8    CGB2    CGB1    CGB7
    FSHB    TSHB

    Find genes that share paralogs with LHB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LHB
    PGOHUM00000258743


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LHB (see all 111)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs50307731,2,,4
    CHypogonadism LHB-related (HGON-LHB)4 pathogenic149695832(-) GCCTCA/GGGTGG 2 Q R mis12Minor allele frequency- G:0.00NA 4
    rs18004471,2,,4
    C,F,Hnon-pathogenic148066115(-) GGCCAT/CGGTGC 2 /R /W mis1 ese318Minor allele frequency- C:0.12MN EU WA EA NS NA CSA 6571
    rs50307741,2,,4
    Cpathogenic149695689(-) GTGGGG/AGTCCC 2 /S /G mis11Minor allele frequency- A:0.00NA 2
    rs42876871,2
    C,A--45896506(+) GCCCCG/TGGCCC 1 -- int10--------
    rs1405025441,2
    C--45896506(+) GCCCCT/-GGCCC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs23875881,2
    C,F,H--45896513(+) GCCCCG/AGGCAG 1 -- int18Minor allele frequency- A:0.37NA EU WA EA CSA 320
    rs2006440941,2
    --45896536(+) GGGCAA/GTAGCC 2 Y syn10--------
    rs2000119611,2
    --45896562(+) GTTGAC/TGGTGA 2 I V mis10--------
    rs10569141,2
    C,F--45896575(-) TGCCCC/AGTGTG 2 /P syn111Minor allele frequency- A:0.46MN EU WA EA NA CSA 4990
    rs65211,2
    C,F--45896593(-) GCTGTG/CGAGAA 2 /V syn1 ese318Minor allele frequency- C:0.47MN EU WA EA NS NA CSA 6573

    HapMap Linkage Disequilibrium report for LHB (49519237 - 49520347 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for LHB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471416CNV Duplication19718026
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    nsv833857CNV Loss17160897
    nsv912251CNV Loss21882294
    dgv3970n71CNV Loss21882294
    esv22462CNV Gain19812545
    nsv9739CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): LHB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LHB
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 152780    OMIM disorders: --

    UniProtKB/Swiss-Prot: LSHB_HUMAN, P01229
  • Hypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 14 diseases for LHB:    
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    frozen shoulder    hypogonadism lhb-related    hypogonadism, hypergonadotropic    leydig cell hypoplasia due to lhb deficiency
    drug psychosis    male pseudohermaphroditism due to defective lh    tendinitis    calcific tendinitis
    parkinson disease 11    pseudohermaphroditism    hypogonadism    asperger syndrome
    infertility    familial prostate cancer

    4 diseases from the University of Copenhagen DISEASES database for LHB:
    Tenosynovitis     Calcific tendinitis     Frozen shoulder     Drug psychosis

    Find genes that share disorders with LHB           About GenesLikeMe

    Genatlas disease: LHB
    fertile eunuchoidism,hypogonadotropic hypogonadism,male infantilism,male infertility in heterozygotes but normal
    sexual development and fertility in female heterozygotes

    Genetic Association Database (GAD): LHB
    Human Genome Epidemiology (HuGE) Navigator: LHB (17 documents)

    Export disorders for LHB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LHB gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with LHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. (PubMed id 1191677)1, 2, 3 Sairam M.R. and Li C.H. (Biochim. Biophys. Acta 1975)
    2. Luteinizing hormone beta-subunit gene (LHbeta) polymorphism in infertility and endometriosis-associated infertility. (PubMed id 20430510)1, 4 Mafra F.A....Barbosa C.P. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2010)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    6. Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19574343)1, 4 Ahn J....Hayes R.B. (Hum. Mol. Genet. 2009)
    7. Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS). (PubMed id 18767927)1, 4 Limer K.L....O'Neill T.W. (J. Bone Miner. Res. 2009)
    8. A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele. (PubMed id 18439297)1, 4 Haasl R.J....Atwood C.S. (BMC Med. Genet. 2008)
    9. Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. (PubMed id 17507624)1, 4 Cunningham J.M....Thibodeau S.N. (amp 2007)
    10. Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta. (PubMed id 16103457)1, 4 Douglas J.A....Cooney K.A. (amp 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3972 HGNC: 6584 AceView: LHB Ensembl:ENSG00000104826 euGenes: HUgn3972
    ECgene: LHB Kegg: 3972 H-InvDB: LHB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LHB Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LHB
    Wikipedia http://en.wikipedia.org/wiki/Luteinizing_hormone

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LHB gene:
    Search GeneIP for patents involving LHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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