Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LGSN Gene

Aliases for LGSN Gene

  • Lengsin, Lens Protein With Glutamine Synthetase Domain 2 3
  • Glutamate-Ammonia Ligase Domain-Containing Protein 1 3 4
  • GLULD1 3 4
  • LGS 3 4
  • Glutamate-Ammonia Ligase (Glutamine Synthetase) Domain Containing 1 2
  • Glutamate-Ammonia Ligase (Glutamine Synthase) Domain Containing 1 3
  • Lens Glutamine Synthase-Like 4

External Ids for LGSN Gene

Previous HGNC Symbols for LGSN Gene

  • GLULD1

Previous GeneCards Identifiers for LGSN Gene

  • GC06M064048
  • GC06M061165

Summaries for LGSN Gene

Entrez Gene Summary for LGSN Gene

  • This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for LGSN Gene

LGSN (Lengsin, Lens Protein With Glutamine Synthetase Domain) is a Protein Coding gene. Diseases associated with LGSN include retinitis pigmentosa. GO annotations related to this gene include glutamate-ammonia ligase activity.

UniProtKB/Swiss-Prot for LGSN Gene

  • May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGSN Gene

Genomics for LGSN Gene

Regulatory Elements for LGSN Gene

Genomic Location for LGSN Gene

Chromosome:
6
Start:
63,275,951 bp from pter
End:
63,567,921 bp from pter
Size:
291,971 bases
Orientation:
Minus strand

Genomic View for LGSN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGSN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGSN Gene

Proteins for LGSN Gene

  • Protein details for LGSN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TDP6-LGSN_HUMAN
    Recommended name:
    Lengsin
    Protein Accession:
    Q5TDP6
    Secondary Accessions:
    • A1L421
    • Q0PVN9
    • Q0PVP0
    • Q9NYJ0

    Protein attributes for LGSN Gene

    Size:
    509 amino acids
    Molecular mass:
    57278 Da
    Quaternary structure:
    • Dodecamer. Interacts with BFSP2 AND VIM (By similarity).

    Alternative splice isoforms for LGSN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LGSN Gene

Proteomics data for LGSN Gene at MOPED

Post-translational modifications for LGSN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGSN Gene

No data available for DME Specific Peptides for LGSN Gene

Domains & Families for LGSN Gene

Protein Domains for LGSN Gene

Suggested Antigen Peptide Sequences for LGSN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TDP6

UniProtKB/Swiss-Prot:

LGSN_HUMAN :
  • Belongs to the glutamine synthetase family.
Family:
  • Belongs to the glutamine synthetase family.
genes like me logo Genes that share domains with LGSN: view

No data available for Gene Families for LGSN Gene

Function for LGSN Gene

Molecular function for LGSN Gene

UniProtKB/Swiss-Prot Function:
May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity).

Gene Ontology (GO) - Molecular Function for LGSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004356 glutamate-ammonia ligase activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LGSN: view

Phenotypes for LGSN Gene

genes like me logo Genes that share phenotypes with LGSN: view

Animal Model Products

miRNA for LGSN Gene

miRTarBase miRNAs that target LGSN

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGSN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LGSN Gene

Localization for LGSN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGSN Gene COMPARTMENTS Subcellular localization image for LGSN gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for LGSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with LGSN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LGSN Gene

Pathways & Interactions for LGSN Gene

SuperPathways for LGSN Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lung Cancer in human,mouse,rat

Interacting Proteins for LGSN Gene

Gene Ontology (GO) - Biological Process for LGSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006542 glutamine biosynthetic process IEA --
GO:0006807 nitrogen compound metabolic process --
genes like me logo Genes that share ontologies with LGSN: view

No data available for Pathways by source and SIGNOR curated interactions for LGSN Gene

Drugs & Compounds for LGSN Gene

(1) Drugs for LGSN Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with LGSN: view

Transcripts for LGSN Gene

Unigene Clusters for LGSN Gene

Lengsin, lens protein with glutamine synthetase domain:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGSN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGSN Gene

No ASD Table

Relevant External Links for LGSN Gene

GeneLoc Exon Structure for
LGSN
ECgene alternative splicing isoforms for
LGSN

Expression for LGSN Gene

mRNA expression in normal human tissues for LGSN Gene

mRNA differential expression in normal tissues according to GTEx for LGSN Gene

This gene is overexpressed in Liver (x16.7) and Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for LGSN Gene

This gene is overexpressed in Vitreous humor (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGSN Gene



SOURCE GeneReport for Unigene cluster for LGSN Gene Hs.149585

mRNA Expression by UniProt/SwissProt for LGSN Gene

Q5TDP6-LGSN_HUMAN
Tissue specificity: Abundantly expressed in lens.
genes like me logo Genes that share expression patterns with LGSN: view

Protein tissue co-expression partners for LGSN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LGSN Gene

Orthologs for LGSN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LGSN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC538526 35
  • 85.11 (n)
  • 83.75 (a)
LGSN 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LGSN 35
  • 84.78 (n)
  • 84.45 (a)
LGSN 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgsn 35
  • 79.76 (n)
  • 79.76 (a)
Lgsn 16
Lgsn 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGSN 35
  • 99.15 (n)
  • 98.43 (a)
LGSN 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgsn 35
  • 78.85 (n)
  • 79.76 (a)
oppossum
(Monodelphis domestica)
Mammalia LGSN 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGSN 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves LGSN 35
  • 70.06 (n)
  • 65.16 (a)
LGSN 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LGSN 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgsn 35
  • 61.16 (n)
  • 54.69 (a)
zebrafish
(Danio rerio)
Actinopterygii lgsn 35
  • 58.3 (n)
  • 54.18 (a)
lgsn 36
  • 38 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU11239 35
  • 41 (n)
  • 27.14 (a)
Species with no ortholog for LGSN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGSN Gene

ENSEMBL:
Gene Tree for LGSN (if available)
TreeFam:
Gene Tree for LGSN (if available)

Paralogs for LGSN Gene

No data available for Paralogs for LGSN Gene

Variants for LGSN Gene

Sequence variations from dbSNP and Humsavar for LGSN Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs12367 -- 63,356,859(+) aagtt(C/T)taggg intron-variant
rs15729 -- 63,356,898(+) catat(A/G)tatac intron-variant
rs482904 -- 63,361,005(+) tgatc(A/G)ttcct intron-variant
rs732948 -- 63,396,681(+) GGGGC(C/T)GGTTC intron-variant
rs733912 -- 63,500,212(-) ATGCT(A/G)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGSN Gene

Variant ID Type Subtype PubMed ID
dgv1958e1 CNV Complex 17122850
esv2732201 CNV Deletion 23290073

Variation tolerance for LGSN Gene

Residual Variation Intolerance Score: 75.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGSN Gene

HapMap Linkage Disequilibrium report
LGSN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGSN Gene

Disorders for LGSN Gene

MalaCards: The human disease database

(1) MalaCards diseases for LGSN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association
Search LGSN in MalaCards View complete list of genes associated with diseases

Relevant External Links for LGSN

Genetic Association Database (GAD)
LGSN
Human Genome Epidemiology (HuGE) Navigator
LGSN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGSN
genes like me logo Genes that share disorders with LGSN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGSN Gene

Publications for LGSN Gene

  1. Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4. (PMID: 19459848) Nakatsugawa M. … Sato N. (Cancer Sci. 2009) 23 67
  2. Lengsin expression and function during zebrafish lens formation. (PMID: 18406404) Harding R.L. … Vihtelic T.S. (Exp. Eye Res. 2008) 23 67
  3. Expressed sequence tag analysis of guinea pig (Cavia porcellus) eye tissues for NEIBank. (PMID: 19104676) Simpanya M.F. … Mitton K.P. (Mol. Vis. 2008) 23 67
  4. Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens. (PMID: 17161372) Wyatt K. … Wistow G. (Structure 2006) 23 67
  5. Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens. (PMID: 17010935) Grassi F. … Ottonello S. (Biochem. Biophys. Res. Commun. 2006) 23 67

Products for LGSN Gene

Sources for LGSN Gene

Back to Top

Content