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Aliases for LGR6 Gene

Aliases for LGR6 Gene

  • Leucine-Rich Repeat Containing G Protein-Coupled Receptor 6 2 3
  • Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 6 2 3
  • Gonadotropin Receptor 3
  • VTS20631 3
  • GPCR 3

External Ids for LGR6 Gene

Previous GeneCards Identifiers for LGR6 Gene

  • GC01P199847
  • GC01P197596
  • GC01P198629
  • GC01P199451
  • GC01P199461
  • GC01P198894
  • GC01P200429
  • GC01P173328

Summaries for LGR6 Gene

Entrez Gene Summary for LGR6 Gene

  • This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGR6 Gene

LGR6 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 6) is a Protein Coding gene. Diseases associated with LGR6 include myxedema. Among its related pathways are Signaling by GPCR and Signaling by Wnt. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is TSHR.

UniProtKB/Swiss-Prot for LGR6 Gene

  • Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Gene Wiki entry for LGR6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGR6 Gene

Genomics for LGR6 Gene

Regulatory Elements for LGR6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LGR6 Gene

Chromosome:
1
Start:
202,193,901 bp from pter
End:
202,319,785 bp from pter
Size:
125,885 bases
Orientation:
Plus strand

Genomic View for LGR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGR6 Gene

Proteins for LGR6 Gene

  • Protein details for LGR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBX8-LGR6_HUMAN
    Recommended name:
    Leucine-rich repeat-containing G-protein coupled receptor 6
    Protein Accession:
    Q9HBX8
    Secondary Accessions:
    • Q5T509
    • Q5T512
    • Q6UY15
    • Q86VU0
    • Q96K69
    • Q9BYD7

    Protein attributes for LGR6 Gene

    Size:
    967 amino acids
    Molecular mass:
    104298 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55071.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LGR6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LGR6 Gene

Proteomics data for LGR6 Gene at MOPED

Post-translational modifications for LGR6 Gene

  • Glycosylation at Asn 34 and Asn 156
  • Modification sites at PhosphoSitePlus

Other Protein References for LGR6 Gene

Antibody Products

No data available for DME Specific Peptides for LGR6 Gene

Domains & Families for LGR6 Gene

Gene Families for LGR6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBX8

UniProtKB/Swiss-Prot:

LGR6_HUMAN :
  • Contains 1 LRRNT domain.
  • Belongs to the G-protein coupled receptor 1 family.
  • Contains 15 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LGR6: view

Function for LGR6 Gene

Molecular function for LGR6 Gene

UniProtKB/Swiss-Prot Function:
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for LGR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity ISS --
GO:0004930 NOT G-protein coupled receptor activity ISS --
GO:0005515 protein binding IPI 21727895
genes like me logo Genes that share ontologies with LGR6: view
genes like me logo Genes that share phenotypes with LGR6: view

Animal Model Products

miRNA for LGR6 Gene

miRTarBase miRNAs that target LGR6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGR6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LGR6 Gene

Localization for LGR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGR6 Gene COMPARTMENTS Subcellular localization image for LGR6 gene
Compartment Confidence
golgi apparatus 4
nucleus 4
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for LGR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with LGR6: view

Pathways & Interactions for LGR6 Gene

genes like me logo Genes that share pathways with LGR6: view

Pathways by source for LGR6 Gene

1 R&D Systems pathway for LGR6 Gene

Interacting Proteins for LGR6 Gene

Gene Ontology (GO) - Biological Process for LGR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030177 positive regulation of Wnt signaling pathway IDA 22615920
GO:0030335 positive regulation of cell migration IDA 22615920
GO:0090263 positive regulation of canonical Wnt signaling pathway ISS --
genes like me logo Genes that share ontologies with LGR6: view

No data available for SIGNOR curated interactions for LGR6 Gene

Drugs & Compounds for LGR6 Gene

(12) Drugs for LGR6 Gene - From: NovoSeek, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
Melatonin Approved Nutra Antagonist Melatonin receptors MT inhibitor 215
cholesterol Experimental Pharma Agonist 0
R-spondin-1 Pharma Full agonist, Agonist 0
R-spondin-2 Pharma Full agonist, Agonist 0

(4) Additional Compounds for LGR6 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
GnRH
prostaglandin f2alpha
Steroid
genes like me logo Genes that share compounds with LGR6: view

Transcripts for LGR6 Gene

Unigene Clusters for LGR6 Gene

Leucine-rich repeat containing G protein-coupled receptor 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGR6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGR6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6:

ExUns: 23b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for LGR6 Gene

GeneLoc Exon Structure for
LGR6
ECgene alternative splicing isoforms for
LGR6

Expression for LGR6 Gene

mRNA expression in normal human tissues for LGR6 Gene

mRNA differential expression in normal tissues according to GTEx for LGR6 Gene

This gene is overexpressed in Artery - Coronary (x13.4) and Artery - Aorta (x12.7).

Protein differential expression in normal tissues from HIPED for LGR6 Gene

This gene is overexpressed in Serum (59.8) and Platelet (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGR6 Gene



SOURCE GeneReport for Unigene cluster for LGR6 Gene Hs.497402

genes like me logo Genes that share expression patterns with LGR6: view

Protein tissue co-expression partners for LGR6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LGR6 Gene

Orthologs for LGR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGR6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LGR6 35
  • 80.68 (n)
  • 76.77 (a)
LGR6 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LGR6 35
  • 86.74 (n)
  • 88.39 (a)
LGR6 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgr6 35
  • 86.42 (n)
  • 90.18 (a)
Lgr6 16
Lgr6 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGR6 35
  • 94.7 (n)
  • 92.62 (a)
LGR6 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgr6 35
  • 86.39 (n)
  • 90.67 (a)
oppossum
(Monodelphis domestica)
Mammalia LGR6 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGR6 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves LGR6 35
  • 73.01 (n)
  • 72.82 (a)
LGR6 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LGR6 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lgr6 35
  • 65.57 (n)
  • 64.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta rk 36
  • 22 (a)
OneToMany
Species with no ortholog for LGR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGR6 Gene

ENSEMBL:
Gene Tree for LGR6 (if available)
TreeFam:
Gene Tree for LGR6 (if available)

Paralogs for LGR6 Gene

Paralogs for LGR6 Gene

(10) SIMAP similar genes for LGR6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LGR6: view

Variants for LGR6 Gene

Sequence variations from dbSNP and Humsavar for LGR6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs59055594 -- 202,299,121(+) CCAGC(A/G)TAGTA intron-variant
rs59280710 -- 202,200,486(+) TATTG(A/G)GAGCA intron-variant
rs59406536 -- 202,295,902(+) GTGTG(-/TGTGTGTGTGTGTG)ACAAT intron-variant
rs59501586 -- 202,294,962(+) TAGGC(C/T)TATGG intron-variant
rs59693302 -- 202,249,665(+) AATTC(A/G)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGR6 Gene

Variant ID Type Subtype PubMed ID
nsv522841 CNV Gain 19592680
esv2721550 CNV Deletion 23290073
esv1167532 CNV Insertion 17803354
esv1458469 CNV Insertion 17803354
esv1038842 CNV Insertion 17803354
esv2721561 CNV Deletion 23290073
esv1257220 CNV Deletion 17803354

Variation tolerance for LGR6 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGR6 Gene

HapMap Linkage Disequilibrium report
LGR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGR6 Gene

Disorders for LGR6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LGR6 Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
myxedema
  • myxoedema
- elite association
Search LGR6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LGR6

Genetic Association Database (GAD)
LGR6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGR6
genes like me logo Genes that share disorders with LGR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGR6 Gene

Publications for LGR6 Gene

  1. The three subfamilies of leucine-rich repeat-containing G protein- coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. (PMID: 10935549) Hsu S.Y. … Hsueh A.J.W. (Mol. Endocrinol. 2000) 2 23 67
  2. Visualization of G protein-coupled receptor (GPCR) interactions in living cells using bimolecular fluorescence complementation (BiFC). (PMID: 20373507) Vidi P.A. … Watts V.J. (Curr Protoc Neurosci 2010) 23 67
  3. Salt bridge integrates GPCR activation with protein trafficking. (PMID: 20160100) Janovick J.A. … Conn P.M. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  4. GPCR expression using baculovirus-infected Sf9 cells. (PMID: 19513645) Aloia A.L. … Leifert W.R. (Methods Mol. Biol. 2009) 23 67
  5. Substructure mining of GPCR ligands reveals activity-class specific functional groups in an unbiased manner. (PMID: 19434836) van der Horst E. … IJzerman A.P. (J Chem Inf Model 2009) 23 67

Products for LGR6 Gene

Sources for LGR6 Gene

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