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Aliases for LGR5 Gene

Aliases for LGR5 Gene

  • Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 2 3 5
  • Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 2 3
  • G-Protein Coupled Receptor HG38 3 4
  • G-Protein Coupled Receptor 49 3 4
  • G-Protein Coupled Receptor 67 3 4
  • GPR49 3 4
  • GPR67 3 4
  • Orphan G Protein-Coupled Receptor HG38 3
  • G Protein-Coupled Receptor 49 2
  • GRP49 3
  • HG38 3
  • FEX 3

External Ids for LGR5 Gene

Previous HGNC Symbols for LGR5 Gene

  • GPR67
  • GPR49

Previous GeneCards Identifiers for LGR5 Gene

  • GC12P070121
  • GC12P071833
  • GC12P068883

Summaries for LGR5 Gene

Entrez Gene Summary for LGR5 Gene

  • The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for LGR5 Gene

LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) is a Protein Coding gene. Diseases associated with LGR5 include Skin Squamous Cell Carcinoma and Colonic Benign Neoplasm. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Signaling by Wnt. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is TSHR.

UniProtKB/Swiss-Prot for LGR5 Gene

  • Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Gene Wiki entry for LGR5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGR5 Gene

Genomics for LGR5 Gene

Regulatory Elements for LGR5 Gene

Enhancers for LGR5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LGR5 on UCSC Golden Path with GeneCards custom track

Promoters for LGR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LGR5 on UCSC Golden Path with GeneCards custom track

Genomic Location for LGR5 Gene

Chromosome:
12
Start:
71,439,162 bp from pter
End:
71,586,310 bp from pter
Size:
147,149 bases
Orientation:
Plus strand

Genomic View for LGR5 Gene

Genes around LGR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGR5 Gene

Proteins for LGR5 Gene

  • Protein details for LGR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75473-LGR5_HUMAN
    Recommended name:
    Leucine-rich repeat-containing G-protein coupled receptor 5
    Protein Accession:
    O75473
    Secondary Accessions:
    • D8MCT0
    • Q4VAM0
    • Q4VAM2
    • Q9UP75

    Protein attributes for LGR5 Gene

    Size:
    907 amino acids
    Molecular mass:
    99998 Da
    Quaternary structure:
    • Identified in a complex composed of RNF43, LGR5 and RSPO1.
    Miscellaneous:
    • LGR5 is used as a marker of adult tissue stem cells in the intestine, stomach, hair follicle, and mammary epithelium.

    Three dimensional structures from OCA and Proteopedia for LGR5 Gene

    Alternative splice isoforms for LGR5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LGR5 Gene

Proteomics data for LGR5 Gene at MOPED

Post-translational modifications for LGR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGR5 Gene

No data available for DME Specific Peptides for LGR5 Gene

Domains & Families for LGR5 Gene

Gene Families for LGR5 Gene

Suggested Antigen Peptide Sequences for LGR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75473

UniProtKB/Swiss-Prot:

LGR5_HUMAN :
  • Contains 1 LRRNT domain.
  • Belongs to the G-protein coupled receptor 1 family.
  • Contains 16 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
Similarity:
  • Contains 16 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LGR5: view

Function for LGR5 Gene

Molecular function for LGR5 Gene

UniProtKB/Swiss-Prot Function:
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Gene Ontology (GO) - Molecular Function for LGR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 21693646
genes like me logo Genes that share ontologies with LGR5: view
genes like me logo Genes that share phenotypes with LGR5: view

Animal Models for LGR5 Gene

MGI Knock Outs for LGR5:

Animal Model Products

  • Taconic Biosciences Mouse Models for LGR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGR5 Gene

Localization for LGR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGR5 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). {ECO:0000269 PubMed:23439653}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGR5 Gene COMPARTMENTS Subcellular localization image for LGR5 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for LGR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032588 trans-Golgi network membrane IDA 23439653
genes like me logo Genes that share ontologies with LGR5: view

Pathways & Interactions for LGR5 Gene

genes like me logo Genes that share pathways with LGR5: view

Interacting Proteins for LGR5 Gene

SIGNOR curated interactions for LGR5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LGR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis IEA --
genes like me logo Genes that share ontologies with LGR5: view

Drugs & Compounds for LGR5 Gene

(5) Drugs for LGR5 Gene - From: PharmGKB, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1697
R-spondin-1 Pharma Full agonist, Agonist 0
R-spondin-2 Pharma Full agonist, Agonist 0
R-spondin-3 Pharma Full agonist, Agonist 0
R-spondin-4 Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with LGR5: view

Transcripts for LGR5 Gene

Unigene Clusters for LGR5 Gene

Leucine-rich repeat containing G protein-coupled receptor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGR5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - - -
SP3: - - - -
SP4:

Relevant External Links for LGR5 Gene

GeneLoc Exon Structure for
LGR5
ECgene alternative splicing isoforms for
LGR5

Expression for LGR5 Gene

mRNA expression in normal human tissues for LGR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGR5 Gene

This gene is overexpressed in Muscle - Skeletal (x12.0) and Brain - Spinal cord (cervical c-1) (x6.5).

Protein differential expression in normal tissues from HIPED for LGR5 Gene

This gene is overexpressed in Spleen (58.4) and Liver (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGR5 Gene



SOURCE GeneReport for Unigene cluster for LGR5 Gene Hs.658889

mRNA Expression by UniProt/SwissProt for LGR5 Gene

O75473-LGR5_HUMAN
Tissue specificity: Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.
genes like me logo Genes that share expression patterns with LGR5: view

Protein tissue co-expression partners for LGR5 Gene

Primer Products

Orthologs for LGR5 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGR5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LGR5 35
  • 88.28 (n)
  • 89.2 (a)
LGR5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgr5 35
  • 84.67 (n)
  • 85.78 (a)
Lgr5 16
Lgr5 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGR5 35
  • 99.49 (n)
  • 99.34 (a)
LGR5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgr5 35
  • 85.08 (n)
  • 86.44 (a)
dog
(Canis familiaris)
Mammalia LGR5 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LGR5 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGR5 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves LGR5 35
  • 77.28 (n)
  • 80.77 (a)
LGR5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LGR5 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgr5 35
  • 71 (n)
  • 73.92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRRK 35
  • 45.2 (n)
  • 33.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta rk 35
  • 44.69 (n)
  • 33.33 (a)
rk 36
  • 20 (a)
OneToMany
Species with no ortholog for LGR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LGR5 Gene

ENSEMBL:
Gene Tree for LGR5 (if available)
TreeFam:
Gene Tree for LGR5 (if available)

Paralogs for LGR5 Gene

Paralogs for LGR5 Gene

(8) SIMAP similar genes for LGR5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LGR5: view

Variants for LGR5 Gene

Sequence variations from dbSNP and Humsavar for LGR5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_049411 -
rs17109924 - 71,584,007(+) CTCTG(C/T)GAAAT intron-variant, reference, missense
rs1920553 -- 71,521,994(+) CTCTA(C/T)TTTGA intron-variant
rs7133186 -- 71,498,705(+) cacaa(A/G)ccttc intron-variant
rs7134447 -- 71,477,264(+) ACTGG(C/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGR5 Gene

Variant ID Type Subtype PubMed ID
dgv300e199 CNV Deletion 23128226
esv22960 CNV Loss 19812545
nsv436156 CNV Deletion 17901297
nsv436661 OTHER Inversion 17901297
esv2746039 CNV Deletion 23290073
esv2746040 CNV Deletion 23290073
esv2746041 CNV Deletion 23290073
esv2746043 CNV Deletion 23290073
esv1359333 CNV Deletion 17803354
nsv826423 CNV Loss 20364138
nsv832451 CNV Loss 17160897

Variation tolerance for LGR5 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LGR5 Gene

Disorders for LGR5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LGR5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
skin squamous cell carcinoma
  • epidermoid skin carcinoma
colonic benign neoplasm
  • colon neoplasm
intestinal benign neoplasm
  • intestinal tumors
- elite association - COSMIC cancer census association via MalaCards
Search LGR5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LGR5

Genetic Association Database (GAD)
LGR5
Human Genome Epidemiology (HuGE) Navigator
LGR5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGR5
genes like me logo Genes that share disorders with LGR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGR5 Gene

Publications for LGR5 Gene

  1. Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily. (PMID: 9642114) McDonald T. … Liu Q. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 67
  2. Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. (PMID: 19549212) Becker L. … Mashimo H. (Dis. Esophagus 2010) 3 23
  3. Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3. (PMID: 19813087) Satoh J. … Kim S.U. (Cell. Mol. Neurobiol. 2010) 3 23
  4. CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. (PMID: 25060070) Hsu H.C. … Chen H.C. (J. Cancer Res. Clin. Oncol. 2015) 3
  5. LGR5/GPR49 is implicated in motor neuron specification in nervous system. (PMID: 25451725) Song S.J. … Xue X.Y. (Neurosci. Lett. 2015) 3

Products for LGR5 Gene

Sources for LGR5 Gene

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