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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LGMN Gene

protein-coding   GIFtS: 62
GCID: GC14M093170

Legumain

(Previous names: protease, cysteine, 1 (legumain))
(Previous symbol: PRSC1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
legumain1 2     EC 3.4.22.343 8
PRSC11 2 3 5     AEP2
Protease, Cysteine, 1 (Legumain)1 2     LGMN12
Asparaginyl Endopeptidase2 3     Cysteine Protease 12
Protease, Cysteine 12 3     

External Ids:    HGNC: 94721   Entrez Gene: 56412   Ensembl: ENSG000001006007   OMIM: 6026205   UniProtKB: Q995383   

Export aliases for LGMN gene to outside databases

Previous GC identifers: GC14M090677 GC14M086987 GC14M091160 GC14M092239 GC14M073353


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LGMN Gene:
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This
enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II
presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be
autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature,
active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of
this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13.
Several alternatively spliced transcript variants have been described, but the biological validity of only two
has been determined. These two variants encode the same isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for LGMN Gene: 
LGMN (legumain) is a protein-coding gene. Diseases associated with LGMN include papillon-lefevre disease, and schistosomiasis, and among its related super-pathways are Immune System and Steroid hormones. GO annotations related to this gene include cysteine-type endopeptidase activity and peptidase activity. An important paralog of this gene is PIGK.

UniProtKB/Swiss-Prot: LGMN_HUMAN, Q99538
Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly,
especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen
presentation in the lysosomal/endosomal system

Gene Wiki entry for LGMN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LGMN gene promoter:
         Max1   USF1   Pbx1a   HSF1 (long)   C/EBPalpha   CHOP-10   Egr-2   HSF2   USF-1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGMN promoter sequence
   Search SABiosciences Chromatin IP Primers for LGMN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGMN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.12

LGMN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGMN gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M093170:  view genomic region     (about GC identifiers)

Start:
93,170,152 bp from pter      End:
93,215,047 bp from pter
Size:
44,896 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LGMN_HUMAN, Q99538 (See protein sequence)
Recommended Name: Legumain precursor  
Size: 433 amino acids; 49411 Da
Subcellular location: Lysosome (By similarity)
Secondary accessions: O00123 Q9BTY1

Explore the universe of human proteins at neXtProt for LGMN: NX_Q99538

Explore proteomics data for LGMN at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99538

  • 4/14 DME Specific Peptides for LGMN (Q99538) (see all 14)
     EACESGS  LDLTPSP  IMKRKLM  NYRHQAD 

    LGMN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LGMN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001008530.1  NP_005597.3  

    ENSEMBL proteins: 
     ENSP00000451861   ENSP00000334052   ENSP00000451854   ENSP00000452572   ENSP00000376911  
     ENSP00000451507   ENSP00000451746   ENSP00000450483   ENSP00000450854   ENSP00000450677  
     ENSP00000451916   ENSP00000452268   ENSP00000451797   ENSP00000450619  
    Reactome Protein details: Q99538
    Human Recombinant Protein Products for LGMN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LGMN (Legumain/Asparaginyl Endopeptidase)
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for LGMN
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    Novus Biologicals LGMN Protein
    Novus Biologicals LGMN Lysates
    Sino Biological Recombinant Protein for LGMN
    Sino Biological Cell Lysate for LGMN 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LGMN 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome ISS--
    GO:0005770late endosome IEA--
    GO:0043202lysosomal lumen TAS--
    GO:0045177apical part of cell IEA--

    LGMN for ontologies           About GeneDecksing



    LGMN Antibody Products: 
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    Abcam antibodies for LGMN
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    LSBio Antibodies in human, mouse, rat for LGMN 

    Assay Products for LGMN: 
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    GenScript LGMN-Activity-based Protease Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LGMN 
    Cloud-Clone Corp. CLIAs for LGMN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001096 Peptidase_C13

    Graphical View of Domain Structure for InterPro Entry Q99538

    ProtoNet protein and cluster: Q99538

    1 Blocks protein domain: IPB001096 Hemoglobinase (C13) cysteine protease signature

    UniProtKB/Swiss-Prot: LGMN_HUMAN, Q99538
    Similarity: Belongs to the peptidase C13 family


    LGMN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LGMN_HUMAN, Q99538
    Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly,
    especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen
    presentation in the lysosomal/endosomal system
    Catalytic activity: Hydrolysis of proteins and small molecule substrates at -Asn- -Xaa- bonds

         Enzyme Number (IUBMB): EC 3.4.22.341 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity ISS--
    GO:0008233peptidase activity IDA136644
         
    LGMN for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lgmn):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  renal/urinary system 

    LGMN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LGMN: Lgmntm1Cptr Lgmntm1Ihn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LGMN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LGMN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LGMN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGMN 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate LGMN:
    hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidLGMN 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of LGMN 

    Cell Line
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    LifeMap BioReagents: cell line associated with LGMN: PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGMN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LGMN About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    2Metabolism of steroid hormones and vitamin D
    Metabolism of steroid hormones and vitamin D1.00
    Steroid hormones1.00
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4TRAF6 Mediated Induction of proinflammatory cytokines
    Toll-Like Receptors Cascades0.87
    5Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.76

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for LGMN
        Immune response Antigen presentation by MHC class II


    1 GeneGo (Thomson Reuters) Pathway for LGMN
        Immune response Antigen presentation by MHC class II


    5/11        Reactome Pathways for LGMN (see all 11)
        Metabolism
    Steroid hormones
    Toll-Like Receptors Cascades
    Adaptive Immune System
    Vitamin D (calciferol) metabolism


    2         Kegg Pathways  (Kegg details for LGMN):
        Lysosome
    Antigen processing and presentation


    LGMN for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LGMN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/37 Interacting proteins for LGMN (Q995383 ENSP000003340524) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP17L24Q0WX573I2D: score=1 
    USP17L25Q0WX573I2D: score=1 
    USP17L26Q0WX573I2D: score=1 
    USP17L27Q0WX573I2D: score=1 
    USP17L28Q0WX573I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001101response to acid IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0003014renal system process ISS--
    GO:0006508proteolysis ISS--
    GO:0008202steroid metabolic process TAS--

    LGMN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LGMN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LGMN

    6 Novoseek inferred chemical compound relationships for LGMN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    clostripain 81.7 3 9891971 (1), 11439111 (1), 11517925 (1)
    cysteine 74.4 42 16650340 (3), 17189693 (2), 11517930 (2), 9065484 (2) (see all 29)
    asparagine 65.5 11 10215615 (2), 17302735 (1), 11985866 (1), 12860980 (1) (see all 8)
    aspartate 20.8 2 9821970 (2)
    histidine 5.33 1 9821970 (1)
    alanine 0 1 9821970 (1)

    Search CenterWatch for drugs/clinical trials and news about LGMN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LGMN gene (2 alternative transcripts): 
    NM_001008530.2  NM_005606.6  

    Unigene Cluster for LGMN:

    Legumain
    Hs.18069  [show with all ESTs]
    Unigene Representative Sequence: NM_001008530
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000555699(uc001yau.3) ENST00000334869(uc001yat.3 uc001yaw.3)
    ENST00000555169 ENST00000557434 ENST00000393218(uc001yav.3) ENST00000557609
    ENST00000556790 ENST00000557725 ENST00000556097 ENST00000554189 ENST00000553802
    ENST00000557694 ENST00000554397 ENST00000554919 ENST00000554080 ENST00000553371
    ENST00000557315 ENST00000553918
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGMN
    1 QIAGEN miScript miRNA Assays for microRNA that regulate LGMN:
    hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidLGMN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene ORF clones in mouse, rat for LGMN
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    GenScript: all cDNA clones in your preferred vector (see all 2): LGMN (NM_001008530)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGMN
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    Additional mRNA sequence: 

    AK225822.1 AK291534.1 AK291560.1 AK297074.1 AK297780.1 BC003061.2 BC013678.1 BX161380.1 
    BX161422.1 BX161434.1 CR457406.1 D55696.1 Y09862.1 

    24/53 DOTS entries (see all 53):

    DT.100892938  DT.100892891  DT.452846  DT.100754052  DT.95171120  DT.91945021  DT.100892915  DT.95092927 
    DT.100892901  DT.100892888  DT.100892879  DT.100892902  DT.100892880  DT.100892908  DT.100716165  DT.100892887 
    DT.100892904  DT.120745008  DT.100728406  DT.100753881  DT.100892894  DT.120744838  DT.120744850  DT.91776608 

    24/912 AceView cDNA sequences (see all 912):

    AI273044 CR619616 AW273809 CA396794 AW069795 AW073922 AU155702 BQ447215 
    AI745103 BX388781 AW131063 CN479070 CR610007 AI499091 BX386514 CD672160 
    BU552711 AU136261 AU156219 CR596286 AW131058 CA308216 CR599951 BE843183 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LGMN (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e
    SP1:                                      -                                                     -     -                                       
    SP2:                                                                                                                                          
    SP3:                                                                                      -     -     -                                       
    SP4:                                                                                      -     -     -     -                                 
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for LGMN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LGMN expression in normal human tissues (normalized intensities)      LGMN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCTTCTG
    LGMN Expression
    About this image


    LGMN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros

    See LGMN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LGMN

    SOURCE GeneReport for Unigene cluster: Hs.18069

    UniProtKB/Swiss-Prot: LGMN_HUMAN, Q99538
    Tissue specificity: Ubiquitous. Particularly abundant in kidney, heart and placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGMN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LGMN gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lgmn1 , 5 legumain1, 5 81.68(n)1
    83.37(a)1
      12 (51.45 cM)5
    191411  NM_011175.21  NP_035305.11 
     1023940845 
    chicken
    (Gallus gallus)
    Aves LGMN1 legumain 73.78(n)
    72.85(a)
      423418  XM_421328.3  XP_421328.1 
    lizard
    (Anolis carolinensis)
    Reptilia LGMN6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    1(11264148-11285360)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056842.12   -- 76.03(n)    BC056842.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb1732 sbcb173 80.24(n)   321137  CA473289.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T28H10.31 Protein T28H10.3 51.91(n)
    43.28(a)
      179714  NM_073736.4  NP_506137.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI86
    ER membrane glycoprotein subunit of the glycosylph...
    22(a)
    1 → many
    IV(1129588-1130823)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DELTA-VPE1 legumain 50.2(n)
    42.01(a)
      821565  NM_112912.2  NP_188656.1 
    rice
    (Oryza sativa)
    Liliopsida Os.41892 Oryza sativa mRNA for asparaginyl endopeptidase, complete more 78.57(n)    AB025310.1 


    ENSEMBL Gene Tree for LGMN (if available)
    TreeFam Gene Tree for LGMN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LGMN gene
    PIGK2  

    LGMN for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for LGMN
    PGOHUM00000261841 PGOHUM00000248419


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1098 SNPs in LGMN are shown (see all 1098)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822235071,2
    --93169687(+) CCAAGC/TAGATG 2 -- int10--------
    rs1403236061,2
    --93169747(+) AGAGAC/TGGGGT 2 -- int10--------
    rs1855118011,2
    --93169848(+) GCCACC/TGCACC 2 -- int10--------
    rs1454762321,2
    --93169925(+) AACTGC/TACCTG 2 -- int10--------
    rs778607341,2
    F--93169935(+) GGAGGA/GTGTGT 2 -- int10--------
    rs1489581601,2
    --93169945(+) TGGAGA/GAGATG 2 -- int10--------
    rs1896424981,2
    --93170048(+) GCAGCA/GGGAGG 2 -- int10--------
    rs745957381,2
    F--93170052(+) CGGGAG/AGGGAG 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1437331871,2
    C--93170090(+) GATGAC/TGGAGG 2 -- int10--------
    rs1807846241,2
    --93170143(+) GTGTCA/GGACGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for LGMN (93170152 - 93215047 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LGMN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1399CNV Insertion18451855
    nsv456399CNV Loss19166990
    nsv456400CNV Loss19166990
    nsv521526CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for LGMN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602620    OMIM disorders: --

    14 diseases for LGMN:    About MalaCards
    papillon-lefevre disease    schistosomiasis    tetanus    cytomegalovirus infection
    oral cancer    atopic dermatitis    colorectal cancer    dermatitis
    psoriasis    breast cancer    ovarian cancer    melanoma
    gastric cancer    neuronitis


    LGMN for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for LGMN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schistosomiasis 34 1 9065484 (1)
    tetanus 27.3 1 12974392 (1)
    solid tumor 24.4 4 16424032 (1), 17028987 (1), 19196156 (1), 20017516 (1)
    multiple sclerosis 7.75 1 15100291 (1)
    metastasis 7.38 4 15788679 (2), 19196156 (1), 16289307 (1)
    colorectal cancer 1.93 5 15788679 (5)
    primary tumor 0 2 15788679 (1)
    breast cancer 0 4 17028987 (4)
    tumors 0 6 15788679 (2), 16424032 (1), 20074384 (1)
    cancer 0 2 19196156 (1), 20017516 (1)


    Export disorders for LGMN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LGMN gene, integrated from 9 sources (see all 105):
    (articles sorted by number of sources associating them with LGMN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. (PubMed id 9065484)1, 2, 3, 9 Chen J.-M.... Barrett A.J. (1997)
    2. Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1. (PubMed id 8893817)1, 2, 3 Tanaka T.... Nakamura Y. (1996)
    3. Autocatalytic activation of human legumain at aspartic acid residues. (PubMed id 9821970)1, 2, 9 Halfon S.... Zurawski G. (1998)
    4. Activation of human prolegumain by cleavage at a C-terminal asparagine residue. (PubMed id 11085925)1, 2, 9 Chen J.-M.... Barrett A.J. (2000)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer. (PubMed id 15788679)1, 9 Murthy R.V....Sun X.F. (2005)
    7. Expression of the cysteine protease legumain in vascu lar lesions and functional implications in atherogenesis. (PubMed id 18377911)1, 9 Clerin V....Pittman D.D. (2008)
    8. Cystatin E/M suppresses legumain activity and invasio n of human melanoma. (PubMed id 20074384)1, 9 Briggs J.J....Solberg R. (2010)
    9. Cloning and expression of mouse legumain, a lysosomal endopeptidase. (PubMed id 9742219)1, 9 Chen J.M....Barrett A.J. (1998)
    10. GARP: a key receptor controlling FOXP3 in human regul atory T cells. (PubMed id 19453521)1, 9 Probst-Kepper M....Weiss S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5641 HGNC: 9472 AceView: LGMN Ensembl:ENSG00000100600 euGenes: HUgn5641
    ECgene: LGMN Kegg: 5641 H-InvDB: LGMN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LGMN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LGMN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LGMN gene:
    Search GeneIP for patents involving LGMN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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