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LGMN Gene

protein-coding   GIFtS: 63
GCID: GC14M093170

Legumain

(Previous names: protease, cysteine, 1 (legumain))
(Previous symbol: PRSC1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
legumain1 2     EC 3.4.22.343 8
PRSC11 2 3 5     AEP2
Protease, Cysteine, 1 (Legumain)1 2     LGMN12
Asparaginyl Endopeptidase2 3     Cysteine Protease 12
Protease, Cysteine 12 3     

External Ids:    HGNC: 94721   Entrez Gene: 56412   Ensembl: ENSG000001006007   OMIM: 6026205   UniProtKB: Q995383   

Export aliases for LGMN gene to outside databases

Previous GC identifers: GC14M090677 GC14M086987 GC14M091160 GC14M092239 GC14M073353


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LGMN Gene:
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This
enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II
presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be
autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature,
active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of
this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13.
Several alternatively spliced transcript variants have been described, but the biological validity of only two
has been determined. These two variants encode the same isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for LGMN Gene:
LGMN (legumain) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity and peptidase activity. An important paralog of this gene is PIGK.

UniProtKB/Swiss-Prot: LGMN_HUMAN, Q99538
Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly,
especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules.
Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via
its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II
antigen presentation in the lysosomal/endosomal system

Gene Wiki entry for LGMN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LGMN gene promoter:
         Max1   USF1   Pbx1a   HSF1 (long)   C/EBPalpha   CHOP-10   Egr-2   HSF2   USF-1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGMN promoter sequence
   Search Chromatin IP Primers for LGMN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LGMN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.1   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.12

LGMN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGMN gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M093170:  view genomic region     (about GC identifiers)

Start:
93,170,152 bp from pter      End:
93,215,047 bp from pter
Size:
44,896 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LGMN_HUMAN, Q99538 (See protein sequence)
Recommended Name: Legumain precursor  
Size: 433 amino acids; 49411 Da
Subunit: Monomer. May interact with integrins
4 PDB 3D structures from and Proteopedia for LGMN:
4AW9 (3D)        4AWA (3D)        4AWB (3D)        4FGU (3D)    
Secondary accessions: O00123 Q9BTY1

Explore the universe of human proteins at neXtProt for LGMN: NX_Q99538

Explore proteomics data for LGMN at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Activated by autocatalytic processing at pH 41
  • Ubiquitination2 at Lys318
  • Glycosylation2 at Asn91, Asn167, Asn263, Asn272
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LGMN (Q99538) (see all 14)
     EACESGS  LDLTPSP  IMKRKLM  NYRHQAD 


    See LGMN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008530.1  NP_005597.3  

    ENSEMBL proteins: 
     ENSP00000451861   ENSP00000334052   ENSP00000451854   ENSP00000452572   ENSP00000376911  
     ENSP00000451507   ENSP00000451746   ENSP00000450483   ENSP00000450854   ENSP00000450677  
     ENSP00000451916   ENSP00000452268   ENSP00000451797   ENSP00000450619  
    Reactome Protein details: Q99538

    LGMN Human Recombinant Protein Products:

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    LGMN Assay Products:

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    Browse Enzo Life Sciences for kits & assays
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    Search eBioscience for ELISAs for LGMN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001096 Peptidase_C13

    Graphical View of Domain Structure for InterPro Entry Q99538

    ProtoNet protein and cluster: Q99538

    1 Blocks protein domain: IPB001096 Hemoglobinase (C13) cysteine protease signature

    UniProtKB/Swiss-Prot: LGMN_HUMAN, Q99538
    Domain: In the zymogen form, the uncleaved propeptide blocks access to the active site
    Similarity: Belongs to the peptidase C13 family


    Find genes that share domains with LGMN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LGMN_HUMAN, Q99538
    Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly,
    especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules.
    Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via
    its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II
    antigen presentation in the lysosomal/endosomal system
    Catalytic activity: Hydrolysis of proteins and small molecule substrates at -Asn- -Xaa- bonds
    Biophysicochemical properties: pH dependence: Optimum pH is 5.5 for the free enzyme, and pH 6 in the presence of
    bound integrins;

         Enzyme Number (IUBMB): EC 3.4.22.341 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity ISS--
    GO:0008233peptidase activity IDA136644
         
    Find genes that share ontologies with LGMN           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lgmn):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  renal/urinary system 

    Find genes that share phenotypes with LGMN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LGMN: Lgmntm1Cptr Lgmntm1Ihn

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    miRNA
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    miRTarBase miRNAs that target LGMN:
    hsa-mir-26b-5p (MIRT029310), hsa-mir-642a-5p (MIRT039572), hsa-mir-192-5p (MIRT026385), hsa-mir-215-5p (MIRT024860)

    Block miRNA regulation of human, mouse, rat LGMN using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LGMN:
    hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidLGMN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LGMN

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    Sino Biological Human cDNA Clone for LGMN
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    Cell Line
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    ESI BIO PureStem Progenitor for LGMN: 
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGMN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LGMN_HUMAN, Q99538: Lysosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome4
    vacuole4
    endosome2
    extracellular2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome ISS--
    GO:0005770late endosome IEA--
    GO:0043202lysosomal lumen TAS--
    GO:0045177apical part of cell IEA--

    Find genes that share ontologies with LGMN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LGMN About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Metabolism of steroid hormones and vitamin D
    Metabolism of steroid hormones and vitamin D
    Vitamin D (calciferol) metabolism0.00
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5Allograft rejection
    Antigen processing and presentation0.36


    Find genes that share SuperPaths with LGMN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for LGMN
        Immune response Antigen presentation by MHC class II


    3 Reactome Pathways for LGMN
        Trafficking and processing of endosomal TLR
    Vitamin D (calciferol) metabolism
    MHC class II antigen presentation


    2 Kegg Pathways  (Kegg details for LGMN):
        Lysosome
    Antigen processing and presentation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LGMN
    Interactions:

        Search GeneGlobe Interaction Network for LGMN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LGMN (Q995383 ENSP000003340524) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP17L24Q0WX573I2D: score=1 
    USP17L25Q0WX573I2D: score=1 
    USP17L26Q0WX573I2D: score=1 
    USP17L27Q0WX573I2D: score=1 
    USP17L28Q0WX573I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001101response to acid IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0003014renal system process ISS--
    GO:0006508proteolysis ISS--
    GO:0008202steroid metabolic process TAS--

    Find genes that share ontologies with LGMN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LGMN

    6 Novoseek inferred chemical compound relationships for LGMN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    clostripain 81.7 3 9891971 (1), 11439111 (1), 11517925 (1)
    cysteine 74.4 42 16650340 (3), 17189693 (2), 11517930 (2), 9065484 (2) (see all 29)
    asparagine 65.5 11 10215615 (2), 17302735 (1), 11985866 (1), 12860980 (1) (see all 8)
    aspartate 20.8 2 9821970 (2)
    histidine 5.33 1 9821970 (1)
    alanine 0 1 9821970 (1)



    Find genes that share compounds with LGMN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LGMN gene (2 alternative transcripts): 
    NM_001008530.2  NM_005606.6  

    Unigene Cluster for LGMN:

    Legumain
    Hs.18069  [show with all ESTs]
    Unigene Representative Sequence: NM_001008530
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000555699(uc001yau.3) ENST00000334869(uc001yat.3 uc001yaw.3)
    ENST00000555169 ENST00000557434 ENST00000393218(uc001yav.3) ENST00000557609
    ENST00000556790 ENST00000557725 ENST00000556097 ENST00000554189 ENST00000553802
    ENST00000557694 ENST00000554397 ENST00000554919 ENST00000554080 ENST00000553371
    ENST00000557315 ENST00000553918
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate LGMN:
    hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidLGMN 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LGMN
      QuantiTect SYBR Green Assays in human, mouse, rat LGMN
      QuantiFast Probe-based Assays in human, mouse, rat LGMN

    Additional mRNA sequence: 

    AK225822.1 AK291534.1 AK291560.1 AK297074.1 AK297780.1 BC003061.2 BC013678.1 BX161380.1 
    BX161422.1 BX161434.1 CR457406.1 D55696.1 Y09862.1 

    Selected DOTS entries (see all 53):

    DT.100892938  DT.100892891  DT.452846  DT.100754052  DT.95171120  DT.91945021  DT.100892915  DT.95092927 
    DT.100892901  DT.100892888  DT.100892879  DT.100892902  DT.100892880  DT.100892908  DT.100716165  DT.100892887 
    DT.100892904  DT.120745008  DT.100728406  DT.100753881  DT.100892894  DT.120744838  DT.120744850  DT.91776608 

    Selected AceView cDNA sequences (see all 912):

    AA569106 CR592073 AW192025 AA298949 AA974440 AI244802 CR616663 CR599951 
    CR590440 CR591060 AI358057 AI190836 BX345604 CR625463 CR624440 AU141319 
    CR617271 CR615884 BM748685 AA379633 AW131058 CR601057 CR611809 CR609822 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LGMN (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e
    SP1:                                      -                                                     -     -                                       
    SP2:                                                                                                                                          
    SP3:                                                                                      -     -     -                                       
    SP4:                                                                                      -     -     -     -                                 
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for LGMN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LGMN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCTTCTG
    LGMN Expression
    About this image


    LGMN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    LGMN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LGMN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18069

    UniProtKB/Swiss-Prot: LGMN_HUMAN, Q99538
    Tissue specificity: Ubiquitous. Particularly abundant in kidney, heart and placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGMN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LGMN gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lgmn1 , 5 legumain1, 5 81.68(n)1
    83.37(a)1
      12 (51.45 cM)5
    191411  NM_011175.21  NP_035305.11 
     1023940845 
    chicken
    (Gallus gallus)
    Aves LGMN1 legumain 73.78(n)
    72.85(a)
      423418  XM_421328.4  XP_421328.1 
    lizard
    (Anolis carolinensis)
    Reptilia LGMN6
    legumain
    67(a)
    1 ↔ 1
    1(11264148-11285360)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056842.12   -- 76.03(n)    BC056842.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb1732 sbcb173 80.24(n)   321137  CA473289.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T28H10.31 T28H10.3 51.66(n)
    43.28(a)
      179714  NM_073736.5  NP_506137.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI86
    ER membrane glycoprotein subunit of the glycosylph...
    22(a)
    1 → many
    IV(1129588-1130823) YDR331W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DELTA-VPE1 DELTA-VPE 50.29(n)
    42.26(a)
      821565  NM_112912.2  NP_188656.1 
    rice
    (Oryza sativa)
    Liliopsida Os.41892 Oryza sativa mRNA for asparaginyl endopeptidase, complete more 78.57(n)    AB025310.1 


    ENSEMBL Gene Tree for LGMN (if available)
    TreeFam Gene Tree for LGMN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LGMN gene
    PIGK2  

    Find genes that share paralogs with LGMN           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for LGMN
    PGOHUM00000261841 PGOHUM00000248419


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LGMN (see all 1098)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822235071,2
    --93169687(+) CCAAGC/TAGATG 2 -- int10--------
    rs1403236061,2
    --93169747(+) AGAGAC/TGGGGT 2 -- int10--------
    rs1855118011,2
    --93169848(+) GCCACC/TGCACC 2 -- int10--------
    rs1454762321,2
    --93169925(+) AACTGC/TACCTG 2 -- int10--------
    rs778607341,2
    F--93169935(+) GGAGGA/GTGTGT 2 -- int10--------
    rs1489581601,2
    --93169945(+) TGGAGA/GAGATG 2 -- int10--------
    rs1896424981,2
    --93170048(+) GCAGCA/GGGAGG 2 -- int10--------
    rs745957381,2
    F--93170052(+) CGGGAG/AGGGAG 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1437331871,2
    C--93170090(+) GATGAC/TGGAGG 2 -- int10--------
    rs1807846241,2
    --93170143(+) GTGTCA/GGACGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for LGMN (93170152 - 93215047 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LGMN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1399CNV Insertion18451855
    nsv456399CNV Loss19166990
    nsv456400CNV Loss19166990
    nsv521526CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LGMN
    DNA2.0 Custom Variant and Variant Library Synthesis for LGMN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602620    OMIM disorders: --


    Find genes that share disorders with LGMN           About GenesLikeMe

    10 Novoseek inferred disease relationships for LGMN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schistosomiasis 34 1 9065484 (1)
    tetanus 27.3 1 12974392 (1)
    solid tumor 24.4 4 16424032 (1), 17028987 (1), 19196156 (1), 20017516 (1)
    multiple sclerosis 7.75 1 15100291 (1)
    metastasis 7.38 4 15788679 (2), 19196156 (1), 16289307 (1)
    colorectal cancer 1.93 5 15788679 (5)
    primary tumor 0 2 15788679 (1)
    breast cancer 0 4 17028987 (4)
    tumors 0 6 15788679 (2), 16424032 (1), 20074384 (1)
    cancer 0 2 19196156 (1), 20017516 (1)


    Export disorders for LGMN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LGMN gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with LGMN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. (PubMed id 9065484)1, 2, 3, 9 Chen J.-M.... Barrett A.J. (J. Biol. Chem. 1997)
    2. Molecular cloning of a human cDNA encoding putative cysteine protease (PRSC1) and its chromosome assignment to 14q32.1. (PubMed id 8893817)1, 2, 3 Tanaka T.... Nakamura Y. (Cytogenet. Cell Genet. 1996)
    3. Autocatalytic activation of human legumain at aspartic acid residues. (PubMed id 9821970)1, 2, 9 Halfon S.... Zurawski G. (FEBS Lett. 1998)
    4. Activation of human prolegumain by cleavage at a C-terminal asparagine residue. (PubMed id 11085925)1, 2, 9 Chen J.-M.... Barrett A.J. (Biochem. J. 2000)
    5. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. (PubMed id 23776206)1, 2 Dall E. and Brandstetter H. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer. (PubMed id 15788679)1, 9 Murthy R.V....Sun X.F. (Clin. Cancer Res. 2005)
    8. Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis. (PubMed id 18377911)1, 9 Clerin V....Pittman D.D. (Atherosclerosis 2008)
    9. Cystatin E/M suppresses legumain activity and invasion of human melanoma. (PubMed id 20074384)1, 9 Briggs J.J....Solberg R. (BMC Cancer 2010)
    10. Cloning and expression of mouse legumain, a lysosomal endopeptidase. (PubMed id 9742219)1, 9 Chen J.M....Barrett A.J. (Biochem. J. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5641 HGNC: 9472 AceView: LGMN Ensembl:ENSG00000100600 euGenes: HUgn5641
    ECgene: LGMN Kegg: 5641 H-InvDB: LGMN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LGMN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LGMN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LGMN gene:
    Search GeneIP for patents involving LGMN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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