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Aliases for LGI3 Gene

Aliases for LGI3 Gene

  • Leucine-Rich Repeat LGI Family Member 3 2 3 5
  • Leucine-Rich Glioma-Inactivated Protein 3 3 4
  • Leucine-Rich Repeat LGI Family, Member 3 2 3
  • LGI1-Like Protein 4 3 4
  • LGIL4 3 4

External Ids for LGI3 Gene

Previous GeneCards Identifiers for LGI3 Gene

  • GC08M021762
  • GC08M022356
  • GC08M021824
  • GC08M022026
  • GC08M022060
  • GC08M020546

Summaries for LGI3 Gene

GeneCards Summary for LGI3 Gene

LGI3 (Leucine-Rich Repeat LGI Family Member 3) is a Protein Coding gene. Among its related pathways are Developmental Biology and LGI-ADAM interactions. An important paralog of this gene is ADGRA1.

UniProtKB/Swiss-Prot for LGI3 Gene

  • May participate in the regulation of neuronal exocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGI3 Gene

Genomics for LGI3 Gene

Regulatory Elements for LGI3 Gene

Enhancers for LGI3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LGI3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LGI3 Gene

Chromosome:
8
Start:
22,146,825 bp from pter
End:
22,157,084 bp from pter
Size:
10,260 bases
Orientation:
Minus strand

Genomic View for LGI3 Gene

Genes around LGI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGI3 Gene

Proteins for LGI3 Gene

  • Protein details for LGI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N145-LGI3_HUMAN
    Recommended name:
    Leucine-rich repeat LGI family member 3
    Protein Accession:
    Q8N145
    Secondary Accessions:
    • A5PLP2
    • Q86TL4
    • Q8N296

    Protein attributes for LGI3 Gene

    Size:
    548 amino acids
    Molecular mass:
    61704 Da
    Quaternary structure:
    • Interacts with STX1A.
    SequenceCaution:
    • Sequence=BAC03553.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LGI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LGI3 Gene

Proteomics data for LGI3 Gene at MOPED

Post-translational modifications for LGI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGI3 Gene

Antibody Products

  • Abcam antibodies for Lgi3

No data available for DME Specific Peptides for LGI3 Gene

Domains & Families for LGI3 Gene

Suggested Antigen Peptide Sequences for LGI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N145

UniProtKB/Swiss-Prot:

LGI3_HUMAN :
  • Contains 1 LRRCT domain.
  • Contains 7 EAR repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 7 EAR repeats.
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LGI3: view

No data available for Gene Families for LGI3 Gene

Function for LGI3 Gene

Molecular function for LGI3 Gene

UniProtKB/Swiss-Prot Function:
May participate in the regulation of neuronal exocytosis.
genes like me logo Genes that share phenotypes with LGI3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LGI3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LGI3 Gene

Localization for LGI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGI3 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse, synaptosome. Note=Found in the synaptosomal membrane fraction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGI3 Gene COMPARTMENTS Subcellular localization image for LGI3 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LGI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with LGI3: view

Pathways & Interactions for LGI3 Gene

genes like me logo Genes that share pathways with LGI3: view

Pathways by source for LGI3 Gene

2 Reactome pathways for LGI3 Gene

Interacting Proteins for LGI3 Gene

Gene Ontology (GO) - Biological Process for LGI3 Gene

None

No data available for SIGNOR curated interactions for LGI3 Gene

Drugs & Compounds for LGI3 Gene

No Compound Related Data Available

Transcripts for LGI3 Gene

Unigene Clusters for LGI3 Gene

Leucine-rich repeat LGI family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGI3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3:

Relevant External Links for LGI3 Gene

GeneLoc Exon Structure for
LGI3
ECgene alternative splicing isoforms for
LGI3

Expression for LGI3 Gene

mRNA expression in normal human tissues for LGI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGI3 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Spinal cord (cervical c-1) (x5.4), Brain - Frontal Cortex (BA9) (x5.0), Brain - Substantia nigra (x4.8), and Brain - Putamen (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for LGI3 Gene

This gene is overexpressed in Frontal cortex (51.3) and Spinal cord (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LGI3 Gene



SOURCE GeneReport for Unigene cluster for LGI3 Gene Hs.33470

mRNA Expression by UniProt/SwissProt for LGI3 Gene

Q8N145-LGI3_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain and lung.
genes like me logo Genes that share expression patterns with LGI3: view

Protein tissue co-expression partners for LGI3 Gene

- Elite partner

Primer Products

Orthologs for LGI3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGI3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LGI3 35
  • 88.44 (n)
  • 92.95 (a)
LGI3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LGI3 35
  • 91.89 (n)
  • 97.72 (a)
LGI3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgi3 35
  • 89.48 (n)
  • 96.53 (a)
Lgi3 16
Lgi3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGI3 35
  • 99.27 (n)
  • 99.64 (a)
LGI3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgi3 35
  • 88.5 (n)
  • 95.99 (a)
oppossum
(Monodelphis domestica)
Mammalia LGI3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGI3 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lgi3 35
  • 64.48 (n)
  • 59.1 (a)
lgi3 36
  • 57 (a)
OneToOne
Species with no ortholog for LGI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGI3 Gene

ENSEMBL:
Gene Tree for LGI3 (if available)
TreeFam:
Gene Tree for LGI3 (if available)

Paralogs for LGI3 Gene

Paralogs for LGI3 Gene

(5) SIMAP similar genes for LGI3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LGI3: view

Variants for LGI3 Gene

Sequence variations from dbSNP and Humsavar for LGI3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs34112456 - 22,148,237(-) GGGAC(A/G/T)CCCAG reference, missense
rs7834247 -- 22,152,837(+) actga(A/G)gtcgg intron-variant
rs7838257 -- 22,150,967(+) AGTTA(C/T)TGCAC intron-variant
rs7838848 -- 22,156,309(+) CCCCA(A/C)CCCCC intron-variant
rs8192305 -- 22,157,565(+) ATTTC(C/T)GCCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LGI3 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
dgv7756n71 CNV Loss 21882294
nsv831263 CNV Loss 17160897
nsv528590 CNV Loss 19592680
nsv890654 CNV Loss 21882294
nsv465613 CNV Loss 19166990
dgv7758n71 CNV Loss 21882294
nsv890657 CNV Loss 21882294
nsv831264 CNV Gain+Loss 17160897
dgv881n27 CNV Loss 19166990
nsv470204 CNV Loss 18288195
nsv527293 CNV Loss 19592680
nsv524720 CNV Loss 19592680
nsv890660 CNV Loss 21882294
nsv890661 CNV Loss 21882294
dgv7759n71 CNV Loss 21882294
dgv7760n71 CNV Loss 21882294

Variation tolerance for LGI3 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LGI3 Gene

Disorders for LGI3 Gene

Relevant External Links for LGI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGI3

No disorders were found for LGI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LGI3 Gene

Publications for LGI3 Gene

  1. The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins. (PMID: 12023020) Gu W. … Steinlein O.K. (FEBS Lett. 2002) 2 3 4 23 67
  2. Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself. (PMID: 18628660) Okabayashi S. … Kimura N. (Neuroreport 2008) 2 3
  3. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 3
  4. Leucine-rich glioma inactivated 3 promotes HaCaT keratinocyte migration. (PMID: 23815230) Jeong Y.M. … Kim D.S. (Wound Repair Regen 2013) 3
  5. Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. (PMID: 19833108) Herranz-PAcrez V. … PAcrez-Tur J. (Brain Res. 2010) 23

Products for LGI3 Gene

Sources for LGI3 Gene

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