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LGI1 Gene

protein-coding GIFtS: 62

GC10P095507

leucine-rich, glioma inactivated 1
(Previous names: epilepsy, partial )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EPT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EPITEMPIN ^¹, ²
EPT ^², ³, ⁵
ETL1 ^¹, ², ⁵
Epitempin-1 ^³
IB1099 ^¹, ²
OTTHUMP00000020121 ^²

Descriptions
epilepsy, partial ^¹
leucine-rich, glioma inactivated 1 ^²

External Ids
HGNC: 6572¹
Entrez Gene: 9211²
UniProtKB: O95970³
Ensembl: ENSG00000108231⁷

Search outside databases for aliases for LGI1 gene

Previous GC identifers: GC10P094410 GC10P094751 GC10P095648 GC10P095182

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LGI1:

This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein

contains a hydrophobic segment representing a putative transmembrane domain with the amino

terminus located outside the cell. It also contains leucine-rich repeats with conserved

cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its

expression is reduced in low grade brain tumors and significantly reduced or absent in malignant

gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided

by RefSeq]

Gene Wiki entry for LGI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LGI1 gene

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q24

LGI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P095507: (about GC identifiers)

Start:	95,507,632 bp from pter
End:	95,547,906 bp from pter
Size:	40,275 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970 (See protein sequence)

Recommended Name: Leucine-rich glioma-inactivated protein 1 precursor

Size: 557 amino acids; 63818 Da

Subcellular location: Secreted (Potential)

Secondary accessions: Q5W001 Q5W002 Q8NI23 Q96LF5

Alternative splicing: 2 isoforms: O95970-1 O95970-2

REFSEQ proteins: NP_005088.1

ENSEMBL proteins:

ENSP00000360472 ENSP00000360467

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Lgi1)
	Human Recombinant Proteins from Abnova (LGI1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for LGI1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LGI1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Lgi1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LGI1)
	Novus Biologicals Antibody for LGI1

Assays for LGI1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95970

ProtoNet protein and cluster: O95970

2 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB000483 Cysteine-rich flanking region

UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970

Similarity: Contains 7 EAR repeats

Similarity: Contains 3 LRR (leucine-rich) repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LGI1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005097

Applied Biosystems Silencer® siRNAs for LGI1

Sigma-Aldrich siRNA and siRNA Panels for LGI1

Sigma-Aldrich shRNA for LGI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LGI1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005097
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005097
untagged cDNA clone in CMV expression vector: NM_005097

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005097

Genatlas biochemistry entry for LGI1:

leucine-rich,glioma inactivated 1,rearranged in glioblastoma cell line t(10;19)(q24;q13),potential

adhesion protein,expressed in the brain

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for LGI1

4 Interacting proteins for LGI1 (ENSP00000360472³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000008277	ENSP00000265727³	STRING (score=.991)
ADAM11	ENSP00000200557³	STRING (score=.901)
ANP32A	ENSP00000267918³	STRING (score=.792)
DLG4	ENSP00000293813³	STRING (score=.786)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007399	nervous system development	TAS	9879993
GO:0008283	cell proliferation	TAS	9879993

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LGI1
2 Novoseek chemical compound relationships for LGI1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	24.18	3	18440780 (1)
sodium	14.30	1	17981785 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LGI1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005097

Sigma-Aldrich siRNA and siRNA Panels for LGI1

Sigma-Aldrich shRNA for LGI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005097

REFSEQ mRNAs for LGI1 gene:

NM_005097.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005097

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005097
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005097
                                 untagged cDNA clone in CMV expression vector: NM_005097

Additional cDNA sequence:

AB209408.1 AF055636.1 AF473548.1 AK289706.1 AK303956.1 AK309416.1 AY358885.1 BC022500.1

CR621199.1 CR621328.1

6 DOTS entries:

DT.40131478 DT.91666709 DT.311317 DT.40302079 DT.91666707 DT.100670435

24/51 AceView cDNA sequences (see all 51 ):

AY358885 AI240096 CR621199 CR621328 AA296979 AI918747 NM_005097 BC022500

BQ718988 BP373601 AI802297 H46267 BF475263 BI752989 BX508343 AI989349

AI039940 BP350084 BI603719 BG699594 H05383 BI550706 AA992473 AA992136

highest scoring ESTs for LGI1:

AA992136 AA992473 AF055636 AI039940 AI621238 AI989349 AW590515 AY358885 BC022500 CD298918

Unigene Cluster for LGI1:

Leucine-rich, glioma inactivated 1

Hs.533670 [show with all ESTs]

Unigene Representative Sequence: AB209408

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for LGI1

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8
SP1:							-								-				-
SP2:							-								-
SP3:
SP4:																			-

About this scheme

ECgene alternative splicing isoforms for LGI1

2 Ensembl transcripts including schematic representations:

ENST00000371418 ENST00000371413

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LGI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LGI1

¹ / ² / ³

4 probe-sets matching LGI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38888_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.81	AF055636	0.80	1.00	0.91	1
81337_at²^{, 3}	U95-D	1	1.00	1.00	0.97	1.22	AI357583	0.60	1.00	0.82	1
206349_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005097	0.60	1.00	0.82	1
206349_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LGI1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTACAGAAA

SOURCE GeneReport for Unigene cluster: Hs.533670
Expression variation in blood from EXPOLDB for LGI1
UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970
Tissue specificity: Predominantly expressed in neural tissues, especially in brain. Expression is
reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LGI1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LGI1¹	--	leucine-rich, glioma inactivated 1	96.23(n) 99.28(a)	477777 XM_534971.2 XP_534971.2
chimpanzee (Pan troglodytes)	LGI1¹	--	leucine-rich, glioma inactivated 1	99.88(n) 99.82(a)	450619 XM_001149068.1 XP_001149068.1
cow (Bos taurus)	LGI1¹	--	leucine-rich, glioma inactivated 1	95(n) 98.87(a)	617080 NM_001046591.2 NP_001040056.2
rat (Rattus norvegicus)	Lgi1¹	--	leucine-rich, glioma inactivated 1	91.98(n) 96.95(a)	252892 NM_145769.2 NP_665712.1
mouse (Mus musculus)	Lgi1^{1, 5}	19⁵	leucine-rich repeat LGI family, member 1^{1, 5}	91.92(n)¹ 96.95(a)¹	56839¹ NM_020278.2¹ NP_064674.1¹ AF246818⁵ AK045443⁵ (see all 9)

About this table Species with no ortholog for LGI1

ENSEMBL Gene Tree for LGI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LGI1 gene

LGI3² LGI4² LGI2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/277 NCBI SNPs in LGI1 are shown (see all 277 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 156)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3758532^1,2	C,F,H	95507161(-)	`TGGGTC/TCCCCA`	1	--	ng5¹		4		EU EA WA	414
	rs10786136^1,2	A,F,H	95506048(+)	`atgccA/Gttccc`	1	--	ng5¹		4		EU EA WA	406
	rs9420627^1,2	C,F,H	95506180(+)	`TAGAAC/TTGCAA`	1	--	ng5¹		4		EU EA WA	410
--	rs7069940^1,2	A,C	95506074(+)	`CTCACC/GAACCC`	1	--	ng5¹		0	--	--	--	--
--	rs3834414^1,2	C,F	95507073(-)	`CTCTCTT/-CTCCC`	1	--	ng5¹ trp³		2		MN EA	1252
--	rs7069934^1,2	A,C	95506066(+)	`GGAGTC/GTTCTC`	1	--	ng5¹		0	--	--	--	--
	rs17502662^1,2	F,H	95547765(+)	`GTAACT/CGTTCT`	1	--	ut3¹		7		NA EU EA WA	562
	rs1111820^1,2	C,F,H	95542643(+)	`GATTTC/TGATTG`	1	F/F	syn¹		11		EA NA EU WA	686
	rs1538598^1,2	A,C,F,H,O	95538743(+)	`ACTACC/TTGGTG`	1	--	int¹		10		NA EA EU WA	610
	rs1108877^1,2	A,C,F,H,O	95542915(+)	`CTTATT/CATTTC`	1	--	int¹		8		NA EU EA WA	566

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HapMap Linkage Disequilibrium images for LGI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604619 disorders: 600512 137800

UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970

Defects in LGI1 are the cause of lateral temporal lobe epilepsy autosomal dominant (ADLTE)

[MIM:600512]; also known as autosomal dominant partial epilepsy with auditory features (ADPEAF).

ADLTE is a form of epilepsy characterized by partial seizures, usually preceded by auditory signs

10/14 Novoseek disease relationships for LGI1 gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adpeaf	99.09	52	15079010 (6), 18440780 (4), 15857855 (3), 17681454 (3) (see all 19)
epilepsy lateral temporal	98.44	12	18625862 (3), 19191227 (2), 17296837 (2), 15009222 (2) (see all 8)
epilepsies partial	81.23	23	15079011 (3), 18711109 (2), 12771268 (2), 15816978 (1) (see all 15)
epilepsy temporal lobe	74.60	13	12023020 (2), 15660777 (1), 15021241 (1), 18355961 (1) (see all 11)
seizures febrile	74.04	3	14598228 (2), 17981785 (1)
epilepsy generalized	66.52	2	15079011 (1), 17981785 (1)
epilepsy	65.05	16	15660777 (2), 15827762 (2), 15816978 (1), 15857855 (1) (see all 14)
epilepsy, idiopathic generalized	64.65	1	15079011 (1)
glioma	61.06	26	12821932 (5), 15047712 (4), 14598228 (2), 15827762 (2) (see all 13)
malignant glioma	55.24	8	11907806 (1), 15827762 (1), 12821932 (1), 10920229 (1)

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GeneTests: LGI1

Autosomal Dominant Partial Epilepsy with Auditory Features

Human Gene Mutation Database: LGI1
Human Genome Epidemiology Navigator: LGI1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/64 PubMed articles for LGI1 gene (see all 64 ):

A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. (PubMed id 9879993)^{1, 2, 3, 4} Chernova O.B.... Cowell J.K. (1998)
Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. (PubMed id 11978770)^{1, 2, 3, 4} Morante-Redolat J.M....Lopez de Munain A. (2002)
LGI1 mutations in temporal lobe epilepsies. (PubMed id 15079010)^{1, 3, 4} Berkovic S.F.... Mulley J.C. (2004)
LGI1 mutations in autosomal dominant partial epilepsy with auditory features. (PubMed id 15079011)^{1, 2, 3} Ottman R....Hauser W.A. (2004)
LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures. (PubMed id 12205652)^{1, 3, 4} Gu W.... Steinlein O.K. (2002)
Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features. (PubMed id 12771268)^{1, 3, 4} Fertig E.... Hisama F.M. (2003)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Epilepsy with auditory features: a LGI1 gene mutation suggests a loss-of-function mechanism. (PubMed id 12601709)^{3, 4} Pizzuti A.... Giallonardo A.T. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9211	HGNC: 6572	AceView: LGI1	Ensembl:ENSG00000108231	euGenes: HUgn9211
ECgene: LGI1	H-InvDB: LGI1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for LGI1	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=LGI1

Licensable Technologies for LGI1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LGI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LGI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LGI1		Antibodies for LGI1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LGI1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for LGI1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for LGI1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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LGI1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for LGI1

Summaries
for LGI1

Genomic Location
for LGI1

Proteins
for LGI1

Protein Domains/
Families
for LGI1

Gene Function
for LGI1

Pathways & Interactions
for LGI1

Drugs & Compounds
for LGI1

Transcripts
for LGI1

Expression
for LGI1

Orthologs
for LGI1

Paralogs
for LGI1

SNPs/Variants
for LGI1

Disorders & Mutations
for LGI1

Medical News
for LGI1

Publications
for LGI1

Search for LGI1

Genome Databases showing LGI1

Other Databases showing LGI1

Specialized Databases showing LGI1

Licensable Technologies
for LGI1

Services
for LGI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LGI1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor LGI1

Summariesfor LGI1

Genomic Locationfor LGI1

Proteinsfor LGI1

Protein Domains/Familiesfor LGI1

Gene Functionfor LGI1

Pathways & Interactionsfor LGI1

Drugs & Compoundsfor LGI1

Transcriptsfor LGI1

Expression for LGI1

Orthologsfor LGI1

Paralogsfor LGI1

SNPs/Variantsfor LGI1

Disorders & Mutationsfor LGI1

Medical Newsfor LGI1

Publicationsfor LGI1

Search for LGI1

Genome Databases showing LGI1

Other Databases showing LGI1

Specialized Databases showing LGI1

Licensable Technologiesfor LGI1

Servicesfor LGI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LGI1

Summaries
for LGI1

Genomic Location
for LGI1

Proteins
for LGI1

Protein Domains/
Families
for LGI1

Gene Function
for LGI1

Pathways & Interactions
for LGI1

Drugs & Compounds
for LGI1

Transcripts
for LGI1

Expression
for LGI1

Orthologs
for LGI1

Paralogs
for LGI1

SNPs/Variants
for LGI1

Disorders & Mutations
for LGI1

Medical News
for LGI1

Publications
for LGI1

Licensable Technologies
for LGI1

Services
for LGI1