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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LGI1 Gene

protein-coding   GIFtS: 59
GCID: GC10P095507

leucine-rich, glioma inactivated 1

(Previous names: epilepsy, partial )
(Previous symbol: EPT)
 Explore 26 diseases affiliated with
LGI1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LGI1    

Aliases
for LGI1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Leucine-Rich, Glioma Inactivated 11 2     ADLTE2
EPT1 2 3 5     ADPAEF2
ETL11 2 5     ADPEAF2
EPITEMPIN1 2     Epitempin-13
IB10991 2     Leucine-Rich Glioma-Inactivated Protein 12
Epilepsy, Partial1     Epitempin-13

External Ids:    HGNC: 65721   Entrez Gene: 92112   Ensembl: ENSG000001082317   OMIM: 6046195   UniProtKB: O959703   

Export aliases for LGI1 gene to outside databases

Previous GC identifers: GC10P094410 GC10P094751 GC10P095648 GC10P095182 GC10P089145


Summaries
for LGI1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LGI1:
This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic
segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also
contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in
neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in
malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970
Function: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel
inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates
synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the
production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of
neuroblastoma cell survival

Gene Wiki entry for LGI1


Genomic Views
for LGI1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LGI1 gene promoter:
         RP58   POU3F1   CUTL1   Gfi-1   Evi-1   E47   Nkx6-1   Hand1   ARP-1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LGI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LGI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24

LGI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGI1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P095507:  view genomic region     (about GC identifiers)

Start:
 95,517,566 bp from pter      End:
 95,557,916 bp from pter
Size:
 40,351 bases      Orientation:
 plus strand

Proteins
for LGI1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970 (See protein sequence)
Recommended Name: Leucine-rich glioma-inactivated protein 1 precursor  
Size: 557 amino acids; 63818 Da
Subunit: Oligomer (By similarity). Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1 (By
similarity). Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2 (stargazin) (By similarity). Can bind to
ADAM11 and ADAM23 (By similarity)
Subcellular location: Secreted. Cell junction, synapse (By similarity). Note=Isoform 1 but not isoform 2 is secreted.
Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum
Secondary accessions: A8K0Z1 B4E1S0 Q5W001 Q5W002 Q8NI23 Q96LF5
Alternative splicing: 3 isoforms:  O95970-1   O95970-2   O95970-3   

Explore the universe of human proteins at neXtProt for LGI1: NX_O95970

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95970

    • LGI1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005088.1  
    ENSEMBL proteins: 
     ENSP00000360472   ENSP00000360467   ENSP00000440763  

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    Novus Biologicals LGI1 Proteins
    Novus Biologicals LGI1 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LGI1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005615extracellular space IDA17067999
    GO:0030054cell junction IEA--
    GO:0045202synapse IEA--


    LGI1 for ontologies           About GeneDecksing



    LGI1 Antibody Products: 
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    Uscn ELISAs and CLIAs for LGI1

    Protein Domains /
    Families
    for LGI1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LGI1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000483 Cys-rich_flank_reg_C
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR005492 EPTP
     IPR000372 LRR-contain_N
     IPR009039 EAR

    Graphical View of Domain Structure for InterPro Entry O95970

    ProtoNet protein and cluster: O95970

    2 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970
    Similarity: Contains 7 EAR repeats
    Similarity: Contains 3 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Function
    for LGI1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970
    Function: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel
    inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates
    synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the
    production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of
    neuroblastoma cell survival
    Induction: Down-regulated in neuroblastoma cells

         Genatlas biochemistry entry for LGI1:
    leucine-rich,glioma inactivated 1,rearranged in glioblastoma cell line t(10;19)(q24;q13),potential adhesion
    protein,expressed in the brain

    miRNA
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    hsa-miR-30c hsa-miR-3910 hsa-miR-579 hsa-miR-548k hsa-miR-1271 hsa-miR-30d hsa-miR-488 hsa-miR-449a
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102NOT receptor binding IPI--
    GO:0005515protein binding IPI--


    LGI1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for LGI1: Lgi1tm1.1Jkc Lgi1tm1Mafu Lgi1tm1.1Ics
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Lgi1):
     adipose tissue  behavior/neurological  growth/size  integument  mortality/aging 
     nervous system  pigmentation  vision/eye 

    LGI1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LGI1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LGI1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for LGI1 (O959703 ENSP000003604724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAM22Q9P0K13, ENSP000002657274I2D: score=2 STRING: ENSP00000265727
    DLG4P783523, ENSP000002938134I2D: score=2 STRING: ENSP00000293813
    GRIN2BQ132243I2D: score=1 
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS9879993
    GO:0007411axon guidance IMP--
    GO:0008283cell proliferation TAS9879993
    GO:0030307positive regulation of cell growth IMP--
    GO:0031175neuron projection development IMP--


    LGI1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LGI1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LGI1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LGI1
    2 Novoseek chemical compound relationships for LGI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 18.6 3 18440780 (1)
    sodium 8.36 1 17981785 (1)

    Search CenterWatch for drugs/clinical trials and news about LGI1 

    Transcripts
    for LGI1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LGI1 gene: 
    NM_005097.2  

    Unigene Cluster for LGI1:

    Leucine-rich, glioma inactivated 1
    Hs.533670  [show with all ESTs]
    Unigene Representative Sequence: AB209408
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371418(uc021pwk.1 uc001kjc.4) ENST00000371413 ENST00000478763
    ENST00000485458 ENST00000464250 ENST00000542308(uc010qnv.2 uc009xui.3)


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    hsa-miR-30c hsa-miR-3910 hsa-miR-579 hsa-miR-548k hsa-miR-1271 hsa-miR-30d hsa-miR-488 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: LGI1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: LGI1
    OriGene siRNA: LGI1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209408.1 AF055636.1 AF473548.1 AK289706.1 AK303956.1 AK309416.1 AY358885.1 BC022500.1 

    6 DOTS entries:

    DT.40131478  DT.91666709  DT.311317  DT.40302079  DT.91666707  DT.100670435 

    24/51 AceView cDNA sequences (see all 51):

    AA296979 CR621199 AI918747 AI802297 CR621328 NM_005097 BC022500 AY358885 
    AI240096 BP373601 BQ718988 BG699594 AA992473 AV721181 AI621238 BI550706 
    H05383 BX508343 AL536594 H46267 BM473390 AF473548 AA992136 BI603719 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LGI1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                    -                       -           -               
    SP2:                    -                       -                           
    SP3:                                                                        
    SP4:                                                        -               


    ECgene alternative splicing isoforms for LGI1

    Expression
    for LGI1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LGI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTACAGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LGI1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LGI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LGI1

    SOURCE GeneReport for Unigene cluster: Hs.533670

    UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970
    Tissue specificity: Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade
    brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is
    detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices,
    putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at
    protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at
    protein level)

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGI1

    Orthologs
    for LGI1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LGI1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LGI11 leucine-rich, glioma inactivated 1 82.76(n)
    88.02(a)    		   423802  NM_001044655.1  NP_001038120.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LGI16
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343219.1(1736488-1754929)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.184252 Xenopus laevis transcribed sequence with weak similarity more 73.53(n)    BX848288.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb78h122 wufb78h12 71.79(n)   323011  BC056753.1 


    ENSEMBL Gene Tree for LGI1 (if available)
    TreeFam Gene Tree for LGI1 (if available) 

    Paralogs
    for LGI1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LGI1 gene
    LGI32  LGI42  LGI22  
    4 SIMAP similar genes for LGI1 using alignment to 1 protein entry:     LGI1_HUMAN:
    LGI3    LGI2    DKFZp666C182    LGI4

    LGI1 for paralogs           About GeneDecksing



    Genomic Variants
    for LGI1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/791 NCBI SNPs in LGI1 are shown (see all 791)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048941661,2
    		Cpathogenic95518037(+) CCGTGC/TGTACT 2 R C mis10--------
    rs289390751,2
    		Cpathogenic95556839(+) TAAATT/GCATAA 2 /C /F mis1 ese32Minor allele frequency- G:0.00NA 4
    rs289378741,2
    		Cpathogenic95557034(+) TGTGGA/CATATC 2 E A mis1 ese31Minor allele frequency- C:0.00NA 2
    rs741503381,2
    		C,--95515581(+) ACATCC/ATTTAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1496785941,2
    		--95515763(+) GCTTGC/TGCAGA 1 -- us2k10--------
    rs764883521,2
    		C,--95515832(+) GAAGCA/GTTCGT 1 -- us2k10--------
    rs1852223991,2
    		--95515898(+) TCCGTA/GAAAAA 1 -- us2k10--------
    rs1163615521,2
    		F,--95515997(+) CCCCTG/CCCTGA 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1911562671,2
    		--95516034(+) CAGATC/TATGAG 1 -- us2k10--------
    rs1157362311,2
    		C,F,--95516050(+) CTTTAT/GGTATG 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for LGI1 (95517566 - 95557916 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for LGI1
         2 CNVs: 43286 61051
         5 Indels: 75361 85435 71089 75359 75360
    Human Gene Mutation Database (HGMD): LGI1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for LGI1

    Disorders / Diseases
    for LGI1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LGI1 for disorders           About GeneDecksing

    OMIM gene information: 604619   
    OMIM disorders: 600512  
    UniProtKB/Swiss-Prot: LGI1_HUMAN, O95970
  • Defects in LGI1 are the cause of epilepsy, familial temporal lobe, type 1 (ETL1) [MIM:600512]. A focal form of
    • epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually
    accompanied by sensory symptoms, most often auditory in nature

    20/26 diseases for LGI1 (see all 26):    About MalaCards
    epilepsies, partial    malignant glioma    autosomal dominant partial epilepsy with auditory features    glioblastoma
    temporal lobe epilepsy    limbic encephalitis    status epilepticus    extrapulmonary tuberculosis
    febrile seizures    generalized epilepsy    oral squamous cell carcinoma    choledocholithiasis
    squamous cell carcinoma    aphasia    seizures    encephalitis
    cholangitis    migraine    alzheimer's disease    tuberculosis

    6 diseases from the University of Copenhagen DISEASES database for LGI1:
    Focal epilepsy     Encephalitis     Malignant glioma     Aphasia
    Idiopathic generalized epilepsy     Benign epilepsy with centrotemporal spikes

    10/14 Novoseek disease relationships for LGI1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpeaf 99.1 66 15079010 (6), 18440780 (4), 15857855 (3), 17681454 (3) (see all 26)
    epilepsy lateral temporal 98.6 18 18625862 (3), 19268539 (2), 19462817 (2), 17296837 (2) (see all 12)
    epilepsies partial 80.7 24 15079011 (3), 18711109 (2), 12771268 (2), 15816978 (1) (see all 16)
    epilepsy temporal lobe 77.1 16 12023020 (2), 19833108 (2), 15660777 (1), 16504945 (1) (see all 13)
    seizures febrile 72.9 4 14598228 (2), 19853223 (1), 17981785 (1)
    epilepsy 69.7 26 20133599 (3), 15660777 (2), 15827762 (2), 15816978 (1) (see all 20)
    glioma 64.1 32 12821932 (5), 15047712 (4), 14598228 (2), 19835947 (2) (see all 18)
    epilepsy generalized 62.7 2 15079011 (1), 17981785 (1)
    epilepsy, idiopathic generalized 60.4 1 15079011 (1)
    malignant glioma 50.5 8 11907806 (1), 15827762 (1), 12821932 (1), 10920229 (1)

    GeneTests: LGI1
    Autosomal Dominant Partial Epilepsy with Auditory Features

    Human Genome Epidemiology (HuGE) Navigator: LGI1 (4 documents)

    Export disorders for LGI1 gene to outside databases

    Publications
    for LGI1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LGI1 gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with LGI1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. (PubMed id 9879993)1, 2, 3, 9 Chernova O.B.... Cowell J.K. (1998)
    2. Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. (PubMed id 11978770)1, 2, 3, 9 Morante-Redolat J.M....Lopez de Munain A. (2002)
    3. LGI1 mutations in temporal lobe epilepsies. (PubMed id 15079010)1, 2, 9 Berkovic S.F.... Mulley J.C. (2004)
    4. Increased expression of LGI1 gene triggers growth inhibition and apoptosis of neuroblastoma cells. (PubMed id 16518856)1, 2, 9 Gabellini N.... Palu G. (2006)
    5. LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway. (PubMed id 15047712)1, 2, 9 Kunapuli P.... Cowell J.K. (2004)
    6. LGI1 mutations in autosomal dominant partial epilepsy with auditory features. (PubMed id 15079011)1, 3, 9 Ottman R....Hauser W.A. (2004)
    7. A novel loss-of-function LGI1 mutation linked to autosomal dominant lateral temporal epilepsy. (PubMed id 18625862)1, 2, 9 Striano P....Nobile C. (2008)
    8. Two novel epilepsy-linked mutations leading to a loss of function of LGI1. (PubMed id 17296837)1, 2, 9 Chabrol E....Baulac S. (2007)
    9. LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy. (PubMed id 19191227)1, 2, 9 Nobile C....Striano P. (2009)
    10. The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. (PubMed id 17067999)1, 2, 9 Sirerol-Piquer M.S.... Perez-Tur J. (2006)

    External Searches for LGI1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LGI1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9211 HGNC: 6572 AceView: LGI1 Ensembl:ENSG00000108231 euGenes: HUgn9211
    ECgene: LGI1 H-InvDB: LGI1

    Other Databases showing LGI1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LGI1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LGI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LGI1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LGI1

    Intellectual Property
    for LGI1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LGI1 gene:
    Search GeneIP for patents involving LGI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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