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Aliases for LGALS9B Gene

Aliases for LGALS9B Gene

  • Lectin, Galactoside Binding Soluble 9B 2 3
  • Lectin, Galactoside-Binding, Soluble, 9B 2 3 5
  • Galectin-9-Like Protein A 3 4
  • Gal-9B 3 4
  • Galectin-9 Pseudogene 3
  • Galectin-9 Like 3

External Ids for LGALS9B Gene

Previous GeneCards Identifiers for LGALS9B Gene

  • GC17M020295
  • GC17M020352

Summaries for LGALS9B Gene

Entrez Gene Summary for LGALS9B Gene

  • This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more centromeric gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS9B Gene

LGALS9B (Lectin, Galactoside Binding Soluble 9B) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS9.

UniProtKB/Swiss-Prot for LGALS9B Gene

  • Binds galactosides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS9B Gene

Genomics for LGALS9B Gene

Regulatory Elements for LGALS9B Gene

Enhancers for LGALS9B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LGALS9B on UCSC Golden Path with GeneCards custom track

Promoters for LGALS9B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LGALS9B on UCSC Golden Path with GeneCards custom track

Genomic Location for LGALS9B Gene

20,449,395 bp from pter
20,467,539 bp from pter
18,145 bases
Minus strand

Genomic View for LGALS9B Gene

Genes around LGALS9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS9B Gene

Proteins for LGALS9B Gene

  • Protein details for LGALS9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NLF8
    • A8K2J8

    Protein attributes for LGALS9B Gene

    356 amino acids
    Molecular mass:
    39660 Da
    Quaternary structure:
    No Data Available
    • The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.

    Alternative splice isoforms for LGALS9B Gene


neXtProt entry for LGALS9B Gene

Proteomics data for LGALS9B Gene at MOPED

Post-translational modifications for LGALS9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS9B Gene

No data available for DME Specific Peptides for LGALS9B Gene

Domains & Families for LGALS9B Gene

Gene Families for LGALS9B Gene

Protein Domains for LGALS9B Gene


Suggested Antigen Peptide Sequences for LGALS9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 galectin domains.
  • Contains 2 galectin domains.
genes like me logo Genes that share domains with LGALS9B: view

Function for LGALS9B Gene

Molecular function for LGALS9B Gene

UniProtKB/Swiss-Prot Function:
Binds galactosides.

Gene Ontology (GO) - Molecular Function for LGALS9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LGALS9B: view
genes like me logo Genes that share phenotypes with LGALS9B: view

Animal Models for LGALS9B Gene

MGI Knock Outs for LGALS9B:

Animal Model Products

CRISPR Products

miRNA for LGALS9B Gene

miRTarBase miRNAs that target LGALS9B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGALS9B Gene

Localization for LGALS9B Gene

Subcellular locations from

Jensen Localization Image for LGALS9B Gene COMPARTMENTS Subcellular localization image for LGALS9B gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LGALS9B Gene

Pathways & Interactions for LGALS9B Gene

SuperPathways for LGALS9B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS9B Gene


No data available for Pathways by source and SIGNOR curated interactions for LGALS9B Gene

Drugs & Compounds for LGALS9B Gene

No Compound Related Data Available

Transcripts for LGALS9B Gene

mRNA/cDNA for LGALS9B Gene

(13) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LGALS9B Gene

Lectin, galactoside-binding, soluble, 9B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS9B Gene

No ASD Table

Relevant External Links for LGALS9B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LGALS9B Gene

mRNA expression in normal human tissues for LGALS9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS9B Gene

This gene is overexpressed in Esophagus - Mucosa (x11.7), Stomach (x11.3), Colon - Transverse (x10.4), and Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for LGALS9B Gene

This gene is overexpressed in Nasal epithelium (61.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGALS9B Gene

SOURCE GeneReport for Unigene cluster for LGALS9B Gene Hs.610820

genes like me logo Genes that share expression patterns with LGALS9B: view

Protein tissue co-expression partners for LGALS9B Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LGALS9B Gene

Orthologs for LGALS9B Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS9B Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Lgals9 35
  • 78 (n)
  • 69.41 (a)
Lgals9 16
Lgals9 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Lgals9 35
  • 79.4 (n)
  • 72.05 (a)
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
  • 73 (a)
(Canis familiaris)
Mammalia LGALS9 36
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
-- 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals9c 35
  • 53.12 (n)
  • 45.48 (a)
(Danio rerio)
Actinopterygii lgals9l1 36
  • 45 (a)
si:ch211-209m20.9 36
  • 42 (a)
zgc:136924 36
  • 42 (a)
zgc:171951 36
  • 43 (a)
zgc:92326 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GALE1 35
  • 44.96 (n)
  • 30.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta galectin 35
  • 41 (n)
  • 30.37 (a)
CG11374 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea lec-12 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
CSA.123 36
  • 29 (a)
Species with no ortholog for LGALS9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LGALS9B Gene

Gene Tree for LGALS9B (if available)
Gene Tree for LGALS9B (if available)

Paralogs for LGALS9B Gene

(15) SIMAP similar genes for LGALS9B Gene using alignment to 3 proteins: Pseudogenes for LGALS9B Gene

genes like me logo Genes that share paralogs with LGALS9B: view

Variants for LGALS9B Gene

Sequence variations from dbSNP and Humsavar for LGALS9B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1682188 -- 20,450,469(+) TCAGG(A/G)TACAA intron-variant
rs1682190 -- 20,451,236(+) TGACC(A/G)CAAGC intron-variant, downstream-variant-500B
rs1682191 -- 20,451,343(+) AATAA(C/T)TTTTT intron-variant, downstream-variant-500B
rs1682192 -- 20,451,391(+) CAGCT(C/T)CCATC intron-variant, downstream-variant-500B
rs1682203 -- 20,458,606(+) AAACA(C/T)AAGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LGALS9B Gene

Variant ID Type Subtype PubMed ID
nsv520772 CNV Loss 19592680
nsv521025 CNV Gain 19592680
nsv471495 CNV Duplication 19718026
nsv469852 CNV Complex 16826518
nsv833397 CNV Loss 17160897
dgv935e1 CNV Complex 17122850
nsv428338 CNV Gain 18775914
dgv936e1 CNV Complex 17122850
nsv833398 CNV Loss 17160897
nsv511599 CNV Loss 21212237
nsv833399 CNV Loss 17160897
nsv821555 CNV Deletion 20802225
esv23447 CNV Gain+Loss 19812545
nsv9507 CNV Gain+Loss 18304495
dgv3102n71 CNV Loss 21882294
nsv471392 CNV Duplication 19718026
nsv907875 CNV Gain 21882294
esv2715742 CNV Deletion 23290073

Variation tolerance for LGALS9B Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.90; 79.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS9B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS9B Gene

Disorders for LGALS9B Gene

Relevant External Links for LGALS9B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LGALS9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LGALS9B Gene

Publications for LGALS9B Gene

  1. Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs. (PMID: 11997339) Park S.S. … Lupski J.R. (Genome Res. 2002) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for LGALS9B Gene

Sources for LGALS9B Gene