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Aliases for LGALS8 Gene

Aliases for LGALS8 Gene

  • Lectin, Galactoside Binding Soluble 8 2 3
  • Lectin, Galactoside-Binding, Soluble, 8 2 3 5
  • Prostate Carcinoma Tumor Antigen 1 3 4
  • Po66 Carbohydrate-Binding Protein 3 4
  • Galectin 8 2 3
  • Po66-CBP 3 4
  • PCTA-1 3 4
  • Gal-8 3 4
  • Po66 Carbohydrate Binding Protein 3
  • Galectin-8g 3
  • PCTA1 3

External Ids for LGALS8 Gene

Previous GeneCards Identifiers for LGALS8 Gene

  • GC01P234819
  • GC01P232135
  • GC01P232978
  • GC01P233722
  • GC01P233007
  • GC01P234748
  • GC01P236681
  • GC01P207138

Summaries for LGALS8 Gene

Entrez Gene Summary for LGALS8 Gene

  • This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS8 Gene

LGALS8 (Lectin, Galactoside Binding Soluble 8) is a Protein Coding gene. Diseases associated with LGALS8 include cholesteatoma and prostatic hypertrophy. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS9B.

UniProtKB/Swiss-Prot for LGALS8 Gene

  • Lectin with a marked preference for 3-O-sialylated and 3-O-sulfated glycans.

Gene Wiki entry for LGALS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS8 Gene

Genomics for LGALS8 Gene

Regulatory Elements for LGALS8 Gene

Genomic Location for LGALS8 Gene

Chromosome:
1
Start:
236,518,000 bp from pter
End:
236,552,981 bp from pter
Size:
34,982 bases
Orientation:
Plus strand

Genomic View for LGALS8 Gene

Genes around LGALS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS8 Gene

Proteins for LGALS8 Gene

  • Protein details for LGALS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00214-LEG8_HUMAN
    Recommended name:
    Galectin-8
    Protein Accession:
    O00214
    Secondary Accessions:
    • O15215
    • Q5T3P5
    • Q5T3Q4
    • Q8TEV1
    • Q96B92
    • Q9BXC8
    • Q9H584
    • Q9H585
    • Q9UEZ6
    • Q9UP32
    • Q9UP33
    • Q9UP34

    Protein attributes for LGALS8 Gene

    Size:
    317 amino acids
    Molecular mass:
    35808 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB51605.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD45402.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD45403.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD45404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD45404.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH15818.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH16486.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LGALS8 Gene

    Alternative splice isoforms for LGALS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LGALS8 Gene

Proteomics data for LGALS8 Gene at MOPED

Post-translational modifications for LGALS8 Gene

  • Ubiquitination at Lys 212 and Lys 237
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for LGALS8 Gene

Domains & Families for LGALS8 Gene

Gene Families for LGALS8 Gene

Protein Domains for LGALS8 Gene

Graphical View of Domain Structure for InterPro Entry

O00214

UniProtKB/Swiss-Prot:

LEG8_HUMAN :
  • Contains two homologous but distinct carbohydrate-binding domains.
Domain:
  • Contains two homologous but distinct carbohydrate-binding domains.
  • Contains 2 galectin domains.
genes like me logo Genes that share domains with LGALS8: view

Function for LGALS8 Gene

Molecular function for LGALS8 Gene

UniProtKB/Swiss-Prot Function:
Lectin with a marked preference for 3-O-sialylated and 3-O-sulfated glycans.
genes like me logo Genes that share phenotypes with LGALS8: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LGALS8 Gene

Localization for LGALS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS8 Gene COMPARTMENTS Subcellular localization image for LGALS8 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LGALS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LGALS8: view

Pathways & Interactions for LGALS8 Gene

SuperPathways for LGALS8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LGALS8 Gene

Drugs & Compounds for LGALS8 Gene

(2) Drugs for LGALS8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for LGALS8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS8: view

Transcripts for LGALS8 Gene

Unigene Clusters for LGALS8 Gene

Lectin, galactoside-binding, soluble, 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6:
SP7: - -
SP8:
SP9: -
SP10: - -
SP11: - -

ExUns: 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for LGALS8 Gene

GeneLoc Exon Structure for
LGALS8
ECgene alternative splicing isoforms for
LGALS8

Expression for LGALS8 Gene

mRNA expression in normal human tissues for LGALS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LGALS8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LGALS8 Gene



SOURCE GeneReport for Unigene cluster for LGALS8 Gene Hs.4082

mRNA Expression by UniProt/SwissProt for LGALS8 Gene

O00214-LEG8_HUMAN
Tissue specificity: Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.
genes like me logo Genes that share expression patterns with LGALS8: view

Protein tissue co-expression partners for LGALS8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LGALS8 Gene

Orthologs for LGALS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LGALS8 35
  • 85.81 (n)
  • 83.75 (a)
LGALS8 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LGALS8 35
  • 89.73 (n)
  • 85.71 (a)
LGALS8 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgals8 35
  • 81.86 (n)
  • 79.75 (a)
Lgals8 16
Lgals8 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGALS8 35
  • 98.79 (n)
  • 97.77 (a)
LGALS8 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgals8 35
  • 83.86 (n)
  • 81.33 (a)
oppossum
(Monodelphis domestica)
Mammalia LGALS8 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves LGALS8 35
  • 67.94 (n)
  • 63.81 (a)
LGALS8 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LGALS8 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals8 35
  • 60.84 (n)
  • 55.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia xgalectin-VIIIa 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-199l3.2 35
  • 55.8 (n)
  • 54.11 (a)
CABZ01042972.1 36
  • 43 (a)
ManyToMany
si:ch211-199l3.2 36
  • 53 (a)
ManyToMany
Species with no ortholog for LGALS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGALS8 Gene

ENSEMBL:
Gene Tree for LGALS8 (if available)
TreeFam:
Gene Tree for LGALS8 (if available)

Paralogs for LGALS8 Gene

genes like me logo Genes that share paralogs with LGALS8: view

Variants for LGALS8 Gene

Sequence variations from dbSNP and Humsavar for LGALS8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_009710 -
VAR_012990 -
VAR_012991 -
VAR_063506 -
rs819412 -- 236,528,592(+) tgtca(C/T)ccagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS8 Gene

Variant ID Type Subtype PubMed ID
nsv516855 CNV Gain 19592680
dgv60n27 CNV Gain 19166990
esv24676 CNV Loss 19812545
esv995705 CNV Gain 20482838

Variation tolerance for LGALS8 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.79; 98.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS8 Gene

HapMap Linkage Disequilibrium report
LGALS8
Human Gene Mutation Database (HGMD)
LGALS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS8 Gene

Disorders for LGALS8 Gene

MalaCards: The human disease database

(4) MalaCards diseases for LGALS8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cholesteatoma
  • congenital cholesteatoma
prostatic hypertrophy
  • prostatic hyperplasia
laryngeal benign neoplasm
  • laryngeal tumor
hypopharynx cancer
  • hypopharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS8

Genetic Association Database (GAD)
LGALS8
Human Genome Epidemiology (HuGE) Navigator
LGALS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS8
genes like me logo Genes that share disorders with LGALS8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS8 Gene

Publications for LGALS8 Gene

  1. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. (PMID: 8692978) Su Z.-Z. … Fisher P.B. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23 67
  2. Evaluation of galectin-8 expression in thyroid tumors. (PMID: 19009371) Savin S. … TatiA8 S. (Med. Oncol. 2009) 3 23
  3. Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. (PMID: 19268462) Cueni L.N. … Detmar M. (Exp. Cell Res. 2009) 3 23
  4. Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. (PMID: 19395456) Massardo L. … Soza A. (Lupus 2009) 3 23
  5. Crystallization and preliminary X-ray diffraction analysis of a protease-resistant mutant form of human galectin-8. (PMID: 19407390) Yoshida H. … Kamitori S. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009) 3 23

Products for LGALS8 Gene

Sources for LGALS8 Gene

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