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Aliases for LGALS8 Gene

Aliases for LGALS8 Gene

  • Galectin 8 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 8 2 3
  • Prostate Carcinoma Tumor Antigen 1 3 4
  • Po66 Carbohydrate-Binding Protein 3 4
  • Po66-CBP 3 4
  • PCTA-1 3 4
  • Gal-8 3 4
  • Po66 Carbohydrate Binding Protein 3
  • Galectin-8g 3
  • Galectin-8 3
  • PCTA1 3

External Ids for LGALS8 Gene

Previous GeneCards Identifiers for LGALS8 Gene

  • GC01P234819
  • GC01P232135
  • GC01P232978
  • GC01P233722
  • GC01P233007
  • GC01P234748
  • GC01P236681
  • GC01P207138

Summaries for LGALS8 Gene

Entrez Gene Summary for LGALS8 Gene

  • This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS8 Gene

LGALS8 (Galectin 8) is a Protein Coding gene. Diseases associated with LGALS8 include Cholesteatoma and Prostatic Hypertrophy. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS4.

UniProtKB/Swiss-Prot for LGALS8 Gene

  • Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3-O-sialylated and 3-O-sulfated glycans (PubMed:21288902).

Gene Wiki entry for LGALS8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS8 Gene

Genomics for LGALS8 Gene

Regulatory Elements for LGALS8 Gene

Enhancers for LGALS8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G236522 1.4 ENCODE dbSUPER 17.3 +5.9 5860 3.0 CREB3L1 FEZF1 YY1 ZNF416 ZNF548 ZNF263 SP3 TBX21 ZFP41 MEF2D ENSG00000230325 ENSG00000273058 HEATR1 MTR LGALS8 GNG4 RPL35P1 LDHAP2 LGALS8-AS1
GH01G236490 1.2 Ensembl dbSUPER 11.3 -27.0 -27028 0.9 ELF3 FOXA2 MLX ARID4B DMAP1 RAD21 THRB ZSCAN9 RARA YY1 LGALS8 LGALS8-AS1 ENO1P1 GC01P236501
GH01G236415 1 FANTOM5 ENCODE 13 -101.5 -101498 2.7 PKNOX1 ETV1 BMI1 ZNF644 ZNF121 GATA2 PAF1 ZNF639 SMARCE1 RFX1 EDARADD LGALS8 LGALS8-AS1 GPR137B MTR GC01P236477
GH01G236501 1.6 Ensembl ENCODE dbSUPER 7.1 -14.7 -14688 3.1 FOXA2 MLX ARNT ARID4B ZBTB7B FOS SP5 ZHX2 MXD4 ZNF592 LGALS8 GC01P236501
GH01G236120 1.1 Ensembl ENCODE 10.3 -397.1 -397132 0.9 HDGF PKNOX1 ETV6 RELB BCLAF1 IKZF2 CREM CBFB JUNB GATAD2B GPR137B LGALS8 LGALS8-AS1 GC01M236115 LOC343508
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LGALS8 on UCSC Golden Path with GeneCards custom track

Genomic Location for LGALS8 Gene

Chromosome:
1
Start:
236,518,000 bp from pter
End:
236,552,981 bp from pter
Size:
34,982 bases
Orientation:
Plus strand

Genomic View for LGALS8 Gene

Genes around LGALS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS8 Gene

Proteins for LGALS8 Gene

  • Protein details for LGALS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00214-LEG8_HUMAN
    Recommended name:
    Galectin-8
    Protein Accession:
    O00214
    Secondary Accessions:
    • O15215
    • Q5T3P5
    • Q5T3Q4
    • Q8TEV1
    • Q96B92
    • Q9BXC8
    • Q9H584
    • Q9H585
    • Q9UEZ6
    • Q9UP32
    • Q9UP33
    • Q9UP34

    Protein attributes for LGALS8 Gene

    Size:
    317 amino acids
    Molecular mass:
    35808 Da
    Quaternary structure:
    • Homodimer (PubMed:21288902, Ref.14). Interacts with CALCOCO2/NDP52 (PubMed:22246324).
    SequenceCaution:
    • Sequence=AAB51605.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD45402.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD45403.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD45404.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD45404.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH15818.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH16486.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LGALS8 Gene

    Alternative splice isoforms for LGALS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LGALS8 Gene

Post-translational modifications for LGALS8 Gene

  • Ubiquitination at isoforms=2212 and posLast=237237
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for LGALS8

No data available for DME Specific Peptides for LGALS8 Gene

Domains & Families for LGALS8 Gene

Gene Families for LGALS8 Gene

Protein Domains for LGALS8 Gene

Graphical View of Domain Structure for InterPro Entry

O00214

UniProtKB/Swiss-Prot:

LEG8_HUMAN :
  • Contains two homologous but distinct carbohydrate-binding domains.
Domain:
  • Contains two homologous but distinct carbohydrate-binding domains.
genes like me logo Genes that share domains with LGALS8: view

Function for LGALS8 Gene

Molecular function for LGALS8 Gene

UniProtKB/Swiss-Prot Function:
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3-O-sialylated and 3-O-sulfated glycans (PubMed:21288902).

Gene Ontology (GO) - Molecular Function for LGALS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030246 carbohydrate binding IEA,IDA 22246324
genes like me logo Genes that share ontologies with LGALS8: view
genes like me logo Genes that share phenotypes with LGALS8: view

Animal Models for LGALS8 Gene

MGI Knock Outs for LGALS8:

Animal Model Products

  • Taconic Biosciences Mouse Models for LGALS8

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGALS8 Gene

Localization for LGALS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS8 Gene

Cytoplasmic vesicle. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS8 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
plasma membrane 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for LGALS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8692978
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 22246324
GO:0016020 membrane IDA 19946888
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with LGALS8: view

Pathways & Interactions for LGALS8 Gene

SuperPathways for LGALS8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098586 cellular response to virus IMP 28077878
GO:0098792 xenophagy IMP 22246324
genes like me logo Genes that share ontologies with LGALS8: view

No data available for Pathways by source and SIGNOR curated interactions for LGALS8 Gene

Drugs & Compounds for LGALS8 Gene

(2) Drugs for LGALS8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for LGALS8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS8: view

Transcripts for LGALS8 Gene

Unigene Clusters for LGALS8 Gene

Lectin, galactoside-binding, soluble, 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6:
SP7: - -
SP8:
SP9: -
SP10: - -
SP11: - -

ExUns: 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for LGALS8 Gene

GeneLoc Exon Structure for
LGALS8
ECgene alternative splicing isoforms for
LGALS8

Expression for LGALS8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LGALS8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LGALS8 Gene



Protein tissue co-expression partners for LGALS8 Gene

NURSA nuclear receptor signaling pathways regulating expression of LGALS8 Gene:

LGALS8

SOURCE GeneReport for Unigene cluster for LGALS8 Gene:

Hs.4082

mRNA Expression by UniProt/SwissProt for LGALS8 Gene:

O00214-LEG8_HUMAN
Tissue specificity: Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.

Evidence on tissue expression from TISSUES for LGALS8 Gene

  • Nervous system(4.9)
  • Skin(4.4)
  • Lung(2.8)
  • Heart(2.3)
  • Intestine(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with LGALS8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS8 Gene

Orthologs for LGALS8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LGALS8 34 35
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia LGALS8 34 35
  • 89.73 (n)
cow
(Bos Taurus)
Mammalia LGALS8 34 35
  • 85.81 (n)
rat
(Rattus norvegicus)
Mammalia Lgals8 34
  • 83.86 (n)
mouse
(Mus musculus)
Mammalia Lgals8 34 16 35
  • 81.86 (n)
oppossum
(Monodelphis domestica)
Mammalia LGALS8 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves LGALS8 34 35
  • 67.94 (n)
lizard
(Anolis carolinensis)
Reptilia LGALS8 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals8 34
  • 60.84 (n)
African clawed frog
(Xenopus laevis)
Amphibia xgalectin-VIIIa 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-199l3.2 34 35
  • 55.8 (n)
CABZ01042972.1 35
  • 43 (a)
ManyToMany
Species where no ortholog for LGALS8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGALS8 Gene

ENSEMBL:
Gene Tree for LGALS8 (if available)
TreeFam:
Gene Tree for LGALS8 (if available)

Paralogs for LGALS8 Gene

Variants for LGALS8 Gene

Sequence variations from dbSNP and Humsavar for LGALS8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000078302 -- 236,543,004(+) TTGAC(C/T)TGCAC intron-variant, reference, synonymous-codon
rs1000104764 -- 236,516,431(+) CAGGT(G/T)GCAGT upstream-variant-2KB
rs1000134814 -- 236,528,707(+) TTTTG(C/T)ATTTT intron-variant
rs1000278248 -- 236,528,046(+) AGTTA(C/T)TTAAA intron-variant
rs1000292001 -- 236,534,938(+) TGCCT(A/G)TAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS8 Gene

Variant ID Type Subtype PubMed ID
dgv591n100 CNV gain 25217958
dgv60n27 CNV gain 19166990
dgv864n54 CNV loss 21841781
esv24676 CNV loss 19812545
esv2762227 CNV gain 21179565
esv2763410 CNV gain 21179565
esv3548955 CNV deletion 23714750
esv3589222 CNV gain 21293372
esv995705 CNV gain 20482838
nsv1003900 CNV gain 25217958
nsv1005877 CNV gain 25217958
nsv1012436 CNV loss 25217958
nsv1119763 CNV deletion 24896259
nsv1119764 CNV deletion 24896259
nsv1122462 CNV deletion 24896259
nsv475491 CNV novel sequence insertion 20440878
nsv516855 CNV gain 19592680
nsv549394 CNV gain 21841781
nsv549403 CNV gain 21841781
nsv549404 CNV loss 21841781
nsv549405 CNV loss 21841781
nsv998009 CNV gain 25217958

Variation tolerance for LGALS8 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.79; 98.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS8 Gene

Human Gene Mutation Database (HGMD)
LGALS8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS8 Gene

Disorders for LGALS8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LGALS8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cholesteatoma
  • congenital cholesteatoma
prostatic hypertrophy
  • prostatic hyperplasia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS8

Genetic Association Database (GAD)
LGALS8
Human Genome Epidemiology (HuGE) Navigator
LGALS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS8
genes like me logo Genes that share disorders with LGALS8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS8 Gene

Publications for LGALS8 Gene

  1. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. (PMID: 8692978) Su Z.-Z. … Fisher P.B. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
  2. Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. (PMID: 10980616) Gopalkrishnan R.V. … Fisher P.B. (Oncogene 2000) 3 4 22 64
  3. PLA2G16 represents a switch between entry and clearance of Picornaviridae. (PMID: 28077878) Staring J. … Brummelkamp T.R. (Nature 2017) 3 4 64
  4. Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. (PMID: 22246324) Thurston T.L. … Randow F. (Nature 2012) 3 4 64
  5. Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans. (PMID: 21288902) Ideo H. … Yamashita K. (J. Biol. Chem. 2011) 3 4 64

Products for LGALS8 Gene

Sources for LGALS8 Gene

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