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Aliases for LGALS7 Gene

Aliases for LGALS7 Gene

  • Lectin, Galactoside Binding Soluble 7 2 3
  • Lectin, Galactoside-Binding, Soluble, 7 2 3 5
  • Galectin 7 2 3
  • P53-Induced Gene 1 Protein 4
  • LGALS7A 3
  • HKL-14 4
  • Gal-7 4
  • GAL7 3
  • PIG1 4
  • PI7 4

External Ids for LGALS7 Gene

Previous GeneCards Identifiers for LGALS7 Gene

  • GC19P039892
  • GC19P039671
  • GC19P043955
  • GC19P043971
  • GC19P043939
  • GC19M043954
  • GC19M039261
  • GC19P035727

Summaries for LGALS7 Gene

Entrez Gene Summary for LGALS7 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS7 Gene

LGALS7 (Lectin, Galactoside Binding Soluble 7) is a Protein Coding gene. Diseases associated with LGALS7 include Postencephalitic Parkinson Disease. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS9B.

UniProtKB/Swiss-Prot for LGALS7 Gene

  • Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.

Gene Wiki entry for LGALS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS7 Gene

Genomics for LGALS7 Gene

Regulatory Elements for LGALS7 Gene

Enhancers for LGALS7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LGALS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for LGALS7 Gene

38,770,968 bp from pter
38,773,517 bp from pter
2,550 bases
Minus strand

Genomic View for LGALS7 Gene

Genes around LGALS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS7 Gene

Proteins for LGALS7 Gene

  • Protein details for LGALS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6IB87

    Protein attributes for LGALS7 Gene

    136 amino acids
    Molecular mass:
    15075 Da
    Quaternary structure:
    • Monomer.
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LGALS7 Gene

neXtProt entry for LGALS7 Gene

Proteomics data for LGALS7 Gene at MOPED

Post-translational modifications for LGALS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LGALS7 Gene

Domains & Families for LGALS7 Gene

Gene Families for LGALS7 Gene

Protein Domains for LGALS7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 galectin domain.
  • Contains 1 galectin domain.
genes like me logo Genes that share domains with LGALS7: view

No data available for Suggested Antigen Peptide Sequences for LGALS7 Gene

Function for LGALS7 Gene

Molecular function for LGALS7 Gene

GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 7
UniProtKB/Swiss-Prot Function:
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Phenotypes for LGALS7 Gene

genes like me logo Genes that share phenotypes with LGALS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LGALS7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS7 Gene

Localization for LGALS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS7 Gene

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Subcellular locations from

Jensen Localization Image for LGALS7 Gene COMPARTMENTS Subcellular localization image for LGALS7 gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LGALS7: view

Pathways & Interactions for LGALS7 Gene

SuperPathways for LGALS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
genes like me logo Genes that share ontologies with LGALS7: view

No data available for Pathways by source and SIGNOR curated interactions for LGALS7 Gene

Drugs & Compounds for LGALS7 Gene

(3) Drugs for LGALS7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-Deoxy-2-Aminogalactose Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0

(4) Additional Compounds for LGALS7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS7: view

Transcripts for LGALS7 Gene

mRNA/cDNA for LGALS7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(56) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LGALS7 Gene

Lectin, galactoside-binding, soluble, 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS7 Gene

No ASD Table

Relevant External Links for LGALS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LGALS7 Gene

mRNA expression in normal human tissues for LGALS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x20.0), Skin - Sun Exposed (Lower leg) (x15.0), and Esophagus - Mucosa (x11.0).

Protein differential expression in normal tissues from HIPED for LGALS7 Gene

This gene is overexpressed in Hair follicle (14.8), Saliva (11.0), Urinary Bladder (8.3), Esophagus (8.3), Skin (6.7), and Urine (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGALS7 Gene

SOURCE GeneReport for Unigene cluster for LGALS7 Gene Hs.702546

mRNA Expression by UniProt/SwissProt for LGALS7 Gene

Tissue specificity: Mainly expressed in stratified squamous epithelium.
genes like me logo Genes that share expression patterns with LGALS7: view

Protein tissue co-expression partners for LGALS7 Gene

- Elite partner

Primer Products

Orthologs for LGALS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LGALS7 35
  • 79.1 (n)
  • 73.88 (a)
-- 36
  • 71 (a)
(Canis familiaris)
Mammalia LOC100855989 35
  • 81.23 (n)
  • 76.3 (a)
  • 74 (a)
(Mus musculus)
Mammalia Lgals7 35
  • 79.17 (n)
  • 77.94 (a)
Grifin 36
  • 27 (a)
(Rattus norvegicus)
Mammalia Lgals7 35
  • 76.96 (n)
  • 72.79 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
(Danio rerio)
Actinopterygii lgals3l 36
  • 19 (a)
fruit fly
(Drosophila melanogaster)
Insecta galectin 36
  • 8 (a)
(Caenorhabditis elegans)
Secernentea lec-12 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
CSA.123 36
  • 15 (a)
Species with no ortholog for LGALS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LGALS7 Gene

Gene Tree for LGALS7 (if available)
Gene Tree for LGALS7 (if available)

Paralogs for LGALS7 Gene

(13) SIMAP similar genes for LGALS7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LGALS7: view

Variants for LGALS7 Gene

Sequence variations from dbSNP and Humsavar for LGALS7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1317169 -- 38,774,345(+) GACCT(C/T)TGGCT upstream-variant-2KB
rs140695578 -- 38,774,589(+) TCAAA(A/T)GCAGA upstream-variant-2KB
rs141051611 -- 38,774,006(+) AACAG(C/T)GGCCA upstream-variant-2KB
rs74428609 -- 38,773,947(+) TGAGA(A/T)CCTCC upstream-variant-2KB
rs2001274 -- 38,774,563(-) AATGC(C/T)AGGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LGALS7 Gene

Variant ID Type Subtype PubMed ID
nsv911668 CNV Loss 21882294
nsv7307 OTHER Inversion 18451855
nsv911670 CNV Gain 21882294
dgv3859n71 CNV Loss 21882294
esv1006530 OTHER Inversion 20482838
nsv9719 CNV Gain 18304495

Variation tolerance for LGALS7 Gene

Gene Damage Index Score: 1.06; 21.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LGALS7 Gene

Disorders for LGALS7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LGALS7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
postencephalitic parkinson disease
  • postencephalitic parkinsonism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LGALS7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS7 Gene

Publications for LGALS7 Gene

  1. Cloning, expression, and chromosome mapping of human galectin-7. (PMID: 7534301) Madsen P. … Celis J.E. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. (PMID: 7729568) Magnaldo T. … Darmon M. (Dev. Biol. 1995) 2 3 23
  3. Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells. (PMID: 20382700) Demers M. … St-Pierre Y. (Am. J. Pathol. 2010) 3 23
  4. Galectin-7: will the lectin's activity establish clinical correlations in head and neck squamous cell and basal cell carcinomas? (PMID: 19012243) Cada Z. … Gabius H.J. (Histol. Histopathol. 2009) 3 23
  5. Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and -7. (PMID: 19148478) Saussez S. … Decaestecker C. (Int. J. Oncol. 2009) 3 23

Products for LGALS7 Gene

Sources for LGALS7 Gene