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Aliases for LGALS7 Gene

Aliases for LGALS7 Gene

  • Lectin, Galactoside-Binding, Soluble, 7 2 3
  • Galectin 7 2 3
  • P53-Induced Gene 1 Protein 4
  • LGALS7 LGALS7B 4
  • Galectin-7 3
  • LGALS7A 3
  • HKL-14 4
  • Gal-7 4
  • GAL7 3
  • PIG1 4
  • PI7 4

External Ids for LGALS7 Gene

Summaries for LGALS7 Gene

Entrez Gene Summary for LGALS7 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS7 Gene

LGALS7 (Lectin, Galactoside-Binding, Soluble, 7) is a Protein Coding gene. Diseases associated with LGALS7 include bladder squamous cell carcinoma. An important paralog of this gene is LGALS9B.

UniProtKB/Swiss-Prot for LGALS7 Gene

  • Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.

Gene Wiki entry for LGALS7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS7 Gene

Genomics for LGALS7 Gene

Genomic Location for LGALS7 Gene

Start:
38,770,968 bp from pter
End:
38,773,517 bp from pter
Size:
2,550 bases
Orientation:
Minus strand

Genomic View for LGALS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGALS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS7 Gene

Regulatory Elements for LGALS7 Gene

Proteins for LGALS7 Gene

  • Protein details for LGALS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47929-LEG7_HUMAN
    Recommended name:
    Galectin-7
    Protein Accession:
    P47929
    Secondary Accessions:
    • Q6IB87

    Protein attributes for LGALS7 Gene

    Size:
    136 amino acids
    Molecular mass:
    15075 Da
    Quaternary structure:
    • Monomer

    Three dimensional structures from OCA and Proteopedia for LGALS7 Gene

neXtProt entry for LGALS7 Gene

Proteomics data for LGALS7 Gene at MOPED

Post-translational modifications for LGALS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LGALS7 Gene

Domains for LGALS7 Gene

Gene Families for LGALS7 Gene

HGNC:
  • LGALS :Lectins, galactoside-binding

Protein Domains for LGALS7 Gene

UniProtKB/Swiss-Prot:

LEG7_HUMAN
Domain:
  • Contains 1 galectin domain.:
    • P47929
genes like me logo Genes that share domains with LGALS7: view

Function for LGALS7 Gene

Molecular function for LGALS7 Gene

GENATLAS Biochemistry: lectin,galactoside-beta binding,soluble 7
UniProtKB/Swiss-Prot Function: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
UniProtKB/Swiss-Prot Induction: By p53/TP53

Gene Ontology (GO) - Molecular Function for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with LGALS7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LGALS7 Gene

Localization for LGALS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS7 Gene

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS7 Gene COMPARTMENTS Subcellular localization image for LGALS7 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3
golgi apparatus 2
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0070062 extracellular exosome --
genes like me logo Genes that share ontologies with LGALS7: view

Pathways for LGALS7 Gene

SuperPathways for LGALS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules --
genes like me logo Genes that share ontologies with LGALS7: view

No data available for Pathways by source for LGALS7 Gene

Compounds for LGALS7 Gene

(2) Drugbank Compounds for LGALS7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-Deoxy-2-Aminogalactose
target
Beta-D-Glucose
50-99-7 target

(5) Novoseek inferred chemical compound relationships for LGALS7 Gene

Compound -log(P) Hits PubMed IDs
n-acetyllactosamine 68.4 2
galactose 42.8 4
lactose 39.5 4
carbohydrates 9.19 2
retinoic acid 4.57 2
genes like me logo Genes that share compounds with LGALS7: view

Transcripts for LGALS7 Gene

mRNA/cDNA for LGALS7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(56) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LGALS7 Gene

Lectin, galactoside-binding, soluble, 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS7 Gene

No ASD Table

Relevant External Links for LGALS7 Gene

GeneLoc Exon Structure for
LGALS7
ECgene alternative splicing isoforms for
LGALS7

Expression for LGALS7 Gene

mRNA expression in normal human tissues for LGALS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (20.0), Skin - Sun Exposed (Lower leg) (15.0), and Esophagus - Mucosa (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LGALS7 Gene

SOURCE GeneReport for Unigene cluster for LGALS7 Gene Hs.702546

mRNA Expression by UniProt/SwissProt for LGALS7 Gene

P47929-LEG7_HUMAN
Tissue specificity: Mainly expressed in stratified squamous epithelium
genes like me logo Genes that share expressions with LGALS7: view

Orthologs for LGALS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 71 (a)
ManyToMany
LGALS7 36
  • 79.1 (n)
  • 73.88 (a)
dog
(Canis familiaris)
Mammalia LGALS7 37
  • 74 (a)
ManyToMany
LOC100855989 36
  • 81.23 (n)
  • 76.3 (a)
mouse
(Mus musculus)
Mammalia Grifin 37
  • 27 (a)
ManyToMany
Lgals7 36
  • 79.17 (n)
  • 77.94 (a)
Lgals7 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Lgals7 36
  • 76.96 (n)
  • 72.79 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 24 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lgals3l 37
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta galectin 37
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lec-12 37
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
ManyToMany
CSA.123 37
  • 15 (a)
ManyToMany
Species with no ortholog for LGALS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LGALS7 Gene

ENSEMBL:
Gene Tree for LGALS7 (if available)
TreeFam:
Gene Tree for LGALS7 (if available)

Paralogs for LGALS7 Gene

Selected SIMAP similar genes for LGALS7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LGALS7: view

Variants for LGALS7 Gene

Sequence variations from dbSNP and Humsavar for LGALS7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1317169 -- 38,774,345(+) GACCT(C/T)TGGCT upstream-variant-2KB
rs2001274 -- 38,774,563(-) AATGC(C/T)AGGCC upstream-variant-2KB
rs3745862 -- 38,771,728(-) CGGGG(C/T)GGGGT intron-variant
rs3745863 -- 38,771,718(-) TGAGG(A/G)GGGTA intron-variant
rs3745864 -- 38,771,716(+) AGGGG(C/G)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS7 Gene

Variant ID Type Subtype PubMed ID
nsv911668 CNV Loss 21882294
nsv7307 OTHER Inversion 18451855
nsv911670 CNV Gain 21882294
dgv3859n71 CNV Loss 21882294
esv1006530 OTHER Inversion 20482838
nsv9719 CNV Gain 18304495

Relevant External Links for LGALS7 Gene

HapMap Linkage Disequilibrium report
LGALS7

Disorders for LGALS7 Gene

(2) University of Copenhagen DISEASES for LGALS7 Gene

(8) Novoseek inferred disease relationships for LGALS7 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 38.9 4
carcinoma 23.1 5
colon carcinoma 21.1 2
cancer 19.9 12
lymphoma 18.6 11
genes like me logo Genes that share disorders with LGALS7: view

No data available for UniProtKB/Swiss-Prot for LGALS7 Gene

Publications for LGALS7 Gene

  1. Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. (PMID: 7729568) Magnaldo T. … Darmon M. (Dev. Biol. 1995) 2 3 4 23
  2. Cloning, expression, and chromosome mapping of human galectin-7. (PMID: 7534301) Madsen P. … Celis J.E. (J. Biol. Chem. 1995) 2 3 4 23
  3. Structural basis for the recognition of carbohydrates by human galectin-7. (PMID: 9760227) Leonidas D.D. … Acharya K.R. (Biochemistry 1998) 3 4 23
  4. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. (PMID: 11706006) Kuwabara I. … Liu F.T. (J. Biol. Chem. 2002) 3 4 23
  5. Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. (PMID: 10500176) Bernerd F. … Magnaldo T. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 23

Products for LGALS7 Gene

Sources for LGALS7 Gene

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