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Aliases for LGALS7 Gene

Aliases for LGALS7 Gene

  • Galectin 7 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 7 2 3
  • P53-Induced Gene 1 Protein 4
  • Galectin-7 3
  • LGALS7A 3
  • HKL-14 4
  • Gal-7 4
  • GAL7 3
  • PIG1 4
  • PI7 4

External Ids for LGALS7 Gene

Previous GeneCards Identifiers for LGALS7 Gene

  • GC19P039892
  • GC19P039671
  • GC19P043955
  • GC19P043971
  • GC19P043939
  • GC19M043954
  • GC19M039261
  • GC19P035727

Summaries for LGALS7 Gene

Entrez Gene Summary for LGALS7 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS7 Gene

LGALS7 (Galectin 7) is a Protein Coding gene. Diseases associated with LGALS7 include Postencephalitic Parkinson Disease and Neurodegeneration With Brain Iron Accumulation 2A. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS7B.

UniProtKB/Swiss-Prot for LGALS7 Gene

  • Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.

Gene Wiki entry for LGALS7 Gene

Additional gene information for LGALS7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS7 Gene

Genomics for LGALS7 Gene

GeneHancer (GH) Regulatory Elements for LGALS7 Gene

Promoters and enhancers for LGALS7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I038773 Promoter/Enhancer 0.9 EPDnew dbSUPER 550.8 0.0 -20 0.1 ZNF335 KLF1 LGALS7 RNU6-140P PAK4 GC19P038763 LGALS7B
GH19I038774 Enhancer 0.6 dbSUPER 550.8 -0.8 -817 0.8 ZNF777 ZNF571 ZNF621 ZIC2 ZNF155 ZNF335 GLIS2 ZNF366 GLIS1 ZNF701 LGALS7 RNU6-140P HNRNPL ZNF573 PLEKHG2 SUPT5H LOC100631378 RN7SL566P ENSG00000269688 SAMD4B
GH19I038769 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 74.6 +3.6 3641 1.2 CTCF KLF1 KLF17 SIN3A MAX KLF5 RAD21 POLR2A SMC3 ZNF143 CAPN12 LGALS7 RNU6-140P PAK4 ENSG00000267892 GC19P038763
GH19I038784 Enhancer 0.7 ENCODE 71.6 -11.2 -11157 0.8 JUN CHD4 ZNF384 CEBPG RAD21 FOSL1 ZNF121 ADNP TRIM24 FOSL2 LGALS7 ECH1 LGALS7B
GH19I038761 Enhancer 0.7 ENCODE 69.4 +10.4 10417 3.9 DRAP1 ZNF384 EBF1 DMAP1 RARA YY1 LCORL ZNF316 RBAK POLR2A GC19P038763 LGALS7 CAPN12 LGALS7B FBXO17 GC19P038739
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LGALS7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LGALS7 gene promoter:

Genomic Locations for LGALS7 Gene

Genomic Locations for LGALS7 Gene
2,550 bases
Minus strand

Genomic View for LGALS7 Gene

Genes around LGALS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS7 Gene

Proteins for LGALS7 Gene

  • Protein details for LGALS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6IB87

    Protein attributes for LGALS7 Gene

    136 amino acids
    Molecular mass:
    15075 Da
    Quaternary structure:
    • Monomer.
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LGALS7 Gene

neXtProt entry for LGALS7 Gene

Post-translational modifications for LGALS7 Gene

No Post-translational modifications

Other Protein References for LGALS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LGALS7 Gene

Domains & Families for LGALS7 Gene

Gene Families for LGALS7 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LGALS7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LGALS7: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LGALS7 Gene

Function for LGALS7 Gene

Molecular function for LGALS7 Gene

GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 7
UniProtKB/Swiss-Prot Function:
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Phenotypes From GWAS Catalog for LGALS7 Gene

Gene Ontology (GO) - Molecular Function for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding TAS --
genes like me logo Genes that share ontologies with LGALS7: view

Phenotypes for LGALS7 Gene

genes like me logo Genes that share phenotypes with LGALS7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS7 Gene

Localization for LGALS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS7 Gene

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS7 gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with LGALS7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LGALS7 Gene

Pathways & Interactions for LGALS7 Gene

SuperPathways for LGALS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS --
genes like me logo Genes that share ontologies with LGALS7: view

No data available for Pathways by source and SIGNOR curated interactions for LGALS7 Gene

Drugs & Compounds for LGALS7 Gene

(4) Drugs for LGALS7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-Deoxy-2-Aminogalactose Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0

(3) Additional Compounds for LGALS7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS7: view

Transcripts for LGALS7 Gene

mRNA/cDNA for LGALS7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LGALS7 Gene

Lectin, galactoside-binding, soluble, 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS7 Gene

No ASD Table

Relevant External Links for LGALS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LGALS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x20.0), Skin - Sun Exposed (Lower leg) (x15.0), and Esophagus - Mucosa (x11.0).

Protein differential expression in normal tissues from HIPED for LGALS7 Gene

This gene is overexpressed in Hair follicle (14.8), Saliva (11.0), Urinary Bladder (8.3), Esophagus (8.3), Skin (6.7), and Urine (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGALS7 Gene

Protein tissue co-expression partners for LGALS7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LGALS7 Gene:


SOURCE GeneReport for Unigene cluster for LGALS7 Gene:


mRNA Expression by UniProt/SwissProt for LGALS7 Gene:

Tissue specificity: Mainly expressed in stratified squamous epithelium.

Evidence on tissue expression from TISSUES for LGALS7 Gene

  • Skin(4.7)
  • Nervous system(4.3)
  • Heart(2.8)
  • Lung(2.8)
  • Blood(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with LGALS7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS7 Gene

Orthologs for LGALS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC100855989 33
  • 81.23 (n)
  • 74 (a)
(Mus musculus)
Mammalia Lgals7 33
  • 79.17 (n)
Grifin 34
  • 27 (a)
(Bos Taurus)
Mammalia LGALS7 33
  • 79.1 (n)
-- 34
  • 71 (a)
(Rattus norvegicus)
Mammalia Lgals7 33
  • 76.96 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
(Danio rerio)
Actinopterygii lgals3l 34
  • 19 (a)
fruit fly
(Drosophila melanogaster)
Insecta galectin 34
  • 8 (a)
(Caenorhabditis elegans)
Secernentea lec-12 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
CSA.123 34
  • 15 (a)
Species where no ortholog for LGALS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LGALS7 Gene

Gene Tree for LGALS7 (if available)
Gene Tree for LGALS7 (if available)

Paralogs for LGALS7 Gene

(13) SIMAP similar genes for LGALS7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LGALS7: view

Variants for LGALS7 Gene

Sequence variations from dbSNP and Humsavar for LGALS7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000870390 -- 38,774,633(-) C/T upstream_transcript_variant
rs1001858294 -- 38,774,562(-) T/C upstream_transcript_variant
rs1002374261 -- 38,774,353(-) C/T upstream_transcript_variant
rs1002756687 -- 38,775,400(-) T/C upstream_transcript_variant
rs1002979312 -- 38,771,260(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS7 Gene

Variant ID Type Subtype PubMed ID
dgv3527n100 CNV gain 25217958
esv1006530 OTHER inversion 20482838
nsv1063592 CNV gain 25217958
nsv7307 OTHER inversion 18451855
nsv9719 CNV gain 18304495

Variation tolerance for LGALS7 Gene

Gene Damage Index Score: 1.06; 21.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LGALS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS7 Gene

Disorders for LGALS7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LGALS7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
postencephalitic parkinson disease
  • postencephalitic parkinsonism
neurodegeneration with brain iron accumulation 2a
  • nbia2a
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LGALS7

genes like me logo Genes that share disorders with LGALS7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS7 Gene

Publications for LGALS7 Gene

  1. Cloning, expression, and chromosome mapping of human galectin-7. (PMID: 7534301) Madsen P … Celis JE (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. (PMID: 7729568) Magnaldo T … Darmon M (Developmental biology 1995) 2 3 4 22 58
  3. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. (PMID: 11706006) Kuwabara I … Liu FT (The Journal of biological chemistry 2002) 3 4 22 58
  4. Structural basis for the recognition of carbohydrates by human galectin-7. (PMID: 9760227) Leonidas DD … Acharya KR (Biochemistry 1998) 3 4 22 58
  5. Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells. (PMID: 20382700) Demers M … St-Pierre Y (The American journal of pathology 2010) 3 22 58

Products for LGALS7 Gene

Sources for LGALS7 Gene

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