Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LGALS7 Gene

protein-coding   GIFtS: 56
GCID: GC19M039261

Lectin, Galactoside-Binding, Soluble, 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lectin, Galactoside-Binding, Soluble, 71 2     Gal-73
Galectin 71 2     HKL-143
GAL72     PI73
LGALS7A2     PIG13
galectin-72     P53-Induced Gene 1 Protein3

External Ids:    HGNC: 65681   Entrez Gene: 39632   Ensembl: ENSG000002050767   OMIM: 6006155   UniProtKB: P479293   

Export aliases for LGALS7 gene to outside databases

Previous GC identifers: GC19P039892 GC19P039671 GC19P043955 GC19P043971 GC19P043939 GC19M043954 GC19P035727


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LGALS7 Gene:
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix
interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed
in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene
(GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. (provided by RefSeq, Jul 2008)

GeneCards Summary for LGALS7 Gene: 
LGALS7 (lectin, galactoside-binding, soluble, 7) is a protein-coding gene. Diseases associated with LGALS7 include gastric papillary adenocarcinoma, and bladder squamous cell carcinoma. An important paralog of this gene is LGALS8.

UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929
Function: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control.
Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release

Gene Wiki entry for LGALS7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LGALS7 gene promoter:
         CREB   NF-1   p53   HSF2   deltaCREB   HSF1 (long)   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGALS7 promoter sequence
   Search SABiosciences Chromatin IP Primers for LGALS7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGALS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.13

LGALS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039261:  view genomic region     (about GC identifiers)

Start:
39,261,608 bp from pter      End:
39,264,157 bp from pter
Size:
2,550 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929 (See protein sequence)
Recommended Name: Galectin-7  
Size: 136 amino acids; 15075 Da
Subunit: Monomer
Subcellular location: Cytoplasm. Nucleus. Secreted (Potential). Note=May be secreted by a non-classical secretory
pathway
6/7 PDB 3D structures from and Proteopedia for LGALS7 (see all 7):
1BKZ (3D)        2GAL (3D)        3GAL (3D)        3ZXE (3D)        3ZXF (3D)        4GAL (3D)    
Secondary accessions: Q6IB87

Explore the universe of human proteins at neXtProt for LGALS7: NX_P47929

Explore proteomics data for LGALS7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P47929

  • LGALS7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LGALS7 Protein Expression
    REFSEQ proteins: NP_002298.1  
    ENSEMBL proteins: 
     ENSP00000367891   ENSP00000472380  

    Human Recombinant Protein Products for LGALS7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LGALS7 (Galectin-7)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LGALS7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for LGALS7
    GenScript Custom Purified and Recombinant Proteins Services for LGALS7
    Novus Biologicals LGALS7 Proteins
    Novus Biologicals LGALS7 Lysate
    Sino Biological Recombinant Protein for LGALS7
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LGALS7
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----

    LGALS7 for ontologies           About GeneDecksing



    LGALS7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LGALS7 (Galectin-7)
    OriGene Antibodies for LGALS7
    OriGene Custom Antibody Services for LGALS7
    GenScript Custom Superior Antibodies Services for LGALS7
    Novus Biologicals LGALS7 Antibodies
    Abcam antibodies for LGALS7
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for LGALS7
    LSBio Antibodies in human, mouse, rat for LGALS7 

    Assay Products for LGALS7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LGALS7
    R&D Systems ELISAs for LGALS7 (Galectin-7)
    GenScript Custom Assay Services for LGALS7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LGALS: Lectins, galactoside-binding

    3 InterPro protein domains:
     IPR001079 Galectin_CRD
     IPR013320 ConA-like_subgrp
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P47929

    ProtoNet protein and cluster: P47929

    1 Blocks protein domain: IPB001079 Galectin

    UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929
    Similarity: Contains 1 galectin domain


    LGALS7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEG7_HUMAN, P47929
    Function: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control.
    Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release
    Induction: By p53/TP53

         Genatlas biochemistry entry for LGALS7:
    lectin,galactoside-beta binding,soluble 7

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding ----
         
    LGALS7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LGALS7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LGALS7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LGALS7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGALS7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS7
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LGALS7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LGALS7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LGALS7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LGALS7
    Sirion Biotech Customized adenovirus for overexpression of LGALS7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LGALS7 (see all 6)
    OriGene ORF clones in mouse, rat for LGALS7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LGALS7 (NM_002307)
    Sino Biological Human cDNA Clone for LGALS7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LGALS7
    Sirion Biotech Customized lentivirus for stable overexpression of LGALS7 
                         Customized lentivirus expression plasmids for stable overexpression of LGALS7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LGALS7
    Search LifeMap BioReagents cell lines for LGALS7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LGALS7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/15 Interacting proteins for LGALS7 (P479292, 3 ENSP000003678914) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CA12O435702, 3, ENSP000001786384MINT-63767 I2D: score=4 STRING: ENSP00000178638
    MAP3K3Q997592, 3MINT-48509 I2D: score=2 
    WIPI1Q5MNZ93, ENSP000002621394I2D: score=3 STRING: ENSP00000262139
    USP1O947823, ENSP000003435264I2D: score=2 STRING: ENSP00000343526
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0007157heterophilic cell-cell adhesion ----

    LGALS7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LGALS7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LGALS7 (LEG7)

    2 DrugBank Compounds for LGALS7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-Deoxy-2-Aminogalactose-- --target--17139284 17016423
    Beta-D-Glucose-- 50-99-7target--17139284 17016423

    5 Novoseek inferred chemical compound relationships for LGALS7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetyllactosamine 68.4 2 9760227 (1), 16242339 (1)
    galactose 42.8 6 9760227 (1), 18421797 (1), 18080343 (1), 15902270 (1)
    lactose 39.5 6 9760227 (1), 17631664 (1), 7534301 (1), 15958565 (1)
    carbohydrates 9.19 2 9760227 (1), 14758069 (1)
    retinoic acid 4.57 2 7729568 (2)

    Search CenterWatch for drugs/clinical trials and news about LGALS7 / LEG7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LGALS7 gene: 
    NM_002307.3  

    Unigene Cluster for LGALS7:

    Lectin, galactoside-binding, soluble, 7
    Hs.702546  [show with all ESTs]
    Unigene Representative Sequence: BM913998
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378626(uc002oje.3) ENST00000599035
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS7
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LGALS7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LGALS7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LGALS7
    Clone
    Products:
         
    OriGene clones in human, mouse for LGALS7 (see all 6)
    OriGene ORF clones in mouse, rat for LGALS7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LGALS7 (NM_002307)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LGALS7
    Sirion Biotech Customized lentivirus for stable overexpression of LGALS7 
                         Customized lentivirus expression plasmids for stable overexpression of LGALS7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LGALS7
    OriGene qSTAR qPCR primer pairs in human, mouse for LGALS7
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat LGALS7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LGALS7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS7

    Additional mRNA sequence: CR456917.1 

    3 DOTS entries:

    DT.97805209  DT.315778  DT.121497722 

    24/56 AceView cDNA sequences (see all 56):

    AW015224 AI826905 CN478604 AI202604 AI659838 AA689478 BC042911 AI143778 
    AI201871 CR456917 BV197147 BC073743 AI094346 BG211253 BC061588 BM020432 
    AI417987 AW516753 BF197794 L07769 AI420402 AI969775 AA716658 AI123909 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LGALS7 expression in normal human tissues (normalized intensities)      LGALS7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LGALS7 Expression
    About this image


    LGALS7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Eye (Sensory Organs)
             retinal amacrine cell p0   
     
     Oral Cavity (Gastrointestinal Tract)
             Tongue   
     
     Heart (Cardiovascular System)

     -- (Integumentary System)
             Skin   

    See LGALS7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LGALS7

    SOURCE GeneReport for Unigene cluster: Hs.702546

    UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929
    Tissue specificity: Mainly expressed in stratified squamous epithelium

        SABiosciences Custom PCR Arrays for LGALS7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LGALS7
    OriGene qSTAR qPCR primer pairs in human, mouse for LGALS7
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat LGALS7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LGALS7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LGALS7 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lgals71 , 5 lectin, galactose binding, soluble 71, 5 79.17(n)1
    77.94(a)1
      7 (16.94 cM)5
    168581  NM_008496.41  NP_032522.21 
     288638535 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    24(a)
    1 → many
    GL343281.1(924786-928669)
    fruit fly
    (Drosophila melanogaster)
    Insecta galectin6
    CG113746
    --
    8(a)
    8(a)
    many ↔ many
    many ↔ many
    2L(71757-76211)
    2L(76348-77783)
    worm
    (Caenorhabditis elegans)
    Secernentea lec-26
    lec-46
    (see all 7)
    Protein LEC-4
    (see all 7)
    3(a)
    16(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    II(10009606-10016060)
    III(3771421-3773333)


    ENSEMBL Gene Tree for LGALS7 (if available)
    TreeFam Gene Tree for LGALS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LGALS7 gene
    LGALS7B1 2  LGALS82  LGALS32  LGALS92  LGALSL2  LGALS9C2  LGALS42  LGALS122  
    LGALS9B2  
    14 SIMAP similar genes for LGALS7 using alignment to 2 protein entries:     LEG7_HUMAN (see all proteins):
    LGALS9    LGALS3    LGALS9C    LGALS12    LGALS8    GRIP1
    LGALS9B    LGALS2    LGALS14    LGALS1    LGALS16    LGALS4
    LGALS13    LGALS10A

    LGALS7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/69 SNPs in LGALS7 are shown (see all 69)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007268381,2
    C--39261153(+) GAGAGA/CAGAGG 1 -- ds50010--------
    rs2019130321,2
    C--39261207(+) GGGATA/CTTATA 1 -- ds50010--------
    rs1998981161,2
    C--39261949(+) AAAAGA/CGGCTT 1 -- int10--------
    rs1877280171,2
    --39262622(+) TGCAGC/GGCGGC 2 A syn10--------
    rs2012094911,2
    C,F--39262681(+) AGAGGA/GGGATG 1 -- int11Minor allele frequency- G:0.05EU 102
    rs1450355211,2
    C--39263027(+) ACACCA/GCAGAA 1 -- int10--------
    rs2008742881,2
    --39263706(+) CAGGGA/CGGATG 2 R L mis10--------
    rs37868521,2
    C,F--39264271(-) GCTTGC/ACCCAG 1 -- us2k11Minor allele frequency- A:0.04EA 1492
    rs1389458801,2
    C--39264333(+) CCCAGA/GGCCCG 1 -- us2k10--------
    rs789398741,2
    F--39264532(+) ATATTA/GGGTCC 1 -- us2k11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for LGALS7 (39261608 - 39264157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LGALS7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911668CNV Loss21882294
    dgv3859n71CNV Loss21882294
    nsv911670CNV Gain21882294
    nsv9719CNV Gain18304495
    nsv7307OTHER Inversion18451855
    esv1006530OTHER Inversion20482838

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LGALS7
    DNA2.0 Custom Variant and Variant Library Synthesis for LGALS7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600615    OMIM disorders: --

    20/21 diseases for LGALS7 (see all 21):    About MalaCards
    gastric papillary adenocarcinoma    bladder squamous cell carcinoma    papillary adenocarcinoma    newcastle disease
    bacteriuria    pyelonephritis    acute pyelonephritis    ovarian cyst
    esophageal squamous cell carcinoma    laryngeal squamous cell carcinoma    basal cell carcinoma    cholesteatoma
    squamous cell carcinoma    laryngitis    neuroblastoma    influenza
    esophagitis    cervicitis    adenocarcinoma    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for LGALS7:
    Influenza     Cancer

    LGALS7 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for LGALS7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 38.9 4 10500176 (1), 19012243 (1), 11706006 (1), 16315769 (1)
    carcinoma 23.1 6 18315601 (1), 16315769 (1), 17283157 (1), 9697310 (1) (see all 5)
    colon carcinoma 21.1 2 11706006 (1), 15313906 (1)
    cancer 19.9 13 17283157 (3), 16429325 (1), 13679866 (1), 18418527 (1) (see all 10)
    lymphoma 18.6 15 15958565 (4), 19596268 (3), 17363605 (2), 19012243 (1) (see all 5)
    metastasis 11.7 5 20382700 (4), 16197887 (1)
    shock 8.25 2 17330866 (1), 19507834 (1)
    tumors 6.47 13 15313906 (3), 9307301 (2), 17363605 (2), 10500176 (1) (see all 7)


    Export disorders for LGALS7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LGALS7 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with LGALS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and chromosome mapping of human galectin-7. (PubMed id 7534301)1, 2, 3, 9 Madsen P.... Celis J.E. (1995)
    2. Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. (PubMed id 7729568)1, 2, 3, 9 Magnaldo T....Darmon M. (1995)
    3. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. (PubMed id 11706006)1, 2, 9 Kuwabara I.... Liu F.T. (2002)
    4. Structural basis for the recognition of carbohydrates by human galectin-7. (PubMed id 9760227)1, 2, 9 Leonidas D.D....Acharya K.R. (1998)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Expression of Galectin-3 and Galectin-7 in thyroid malignancy as potential diagnostic indicators. (PubMed id 18418527)1, 9 Than T.H....Abdullah M.S. (2008)
    7. Overexpression of galectin-7, a myoepithelial cell ma rker, enhances spontaneous metastasis of breast cancer cells. (PubMed id 20382700)1, 9 Demers M....St-Pierre Y. (2010)
    8. Galectin-7: will the lectin's activity establish clinical correlations in head and neck squamous cell and basal cell carcinomas? (PubMed id 19012243)1, 9 Cada Z....Gabius H.J. (2009)
    9. Induction of matrix metalloproteinase-9 by galectin-7 through p38 MAPK signaling in HeLa human cervical epithelial adenocarcinoma ce lls. (PubMed id 19885589)1, 9 Park J.E....Cho M. (2009)
    10. Galectin-7, a marker of all types of stratified epithelia. (PubMed id 9697310)1, 9 Magnaldo T....Darmon M. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3963 HGNC: 6568 AceView: LGALS7 Ensembl:ENSG00000205076 euGenes: HUgn3963
    ECgene: LGALS7 H-InvDB: LGALS7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LGALS7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LGALS7 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00143

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LGALS7 gene:
    Search GeneIP for patents involving LGALS7

    Licensable Technologies for LGALS7 gene:
     Tufts University:  Use of Galectins to treat dry eye syndrome    (see all 2)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for LGALS7 (Galectin-7)   Browse Cell Culture Products  
     ELISAs for LGALS7 (Galectin-7)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for LGALS7 (Galectin-7)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LGALS7   OriGene RNAi products in human, mouse, rat for LGALS7  
     OriGene qPCR primer pairs and template standards for LGALS7   OriGene Protein Over-expression Lysate for LGALS7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LGALS7  
     OriGene qSTAR qPCR primer pairs in human, mouse for LGALS7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LGALS7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LGALS7   OriGene Custom Protein Services for LGALS7  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LGALS7
     QIAGEN SeqTarget long-range PCR primers for resequencing LGALS7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGALS7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LGALS7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LGALS7
     GenScript Custom Purified and Recombinant Proteins Services for LGALS7 GenScript cDNA clones with any tag delivered in your preferred vector for LGALS7
     GenScript Custom Assay Services for LGALS7 GenScript Custom Superior Antibodies Services for LGALS7
     GenScript Custom overexpressing Cell Line Services for LGALS7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LGALS7 promoter
     Search Chromatin IP Primers for LGALS7
     Search RT2 qPCR Primer Assays in human, mouse, rat LGALS7
     Search GNC Networks for LGALS7
     SABiosciences Custom PCR Arrays for LGALS7
     Search Tocris compounds for LGALS7 (LEG7)
     Proteins and Antibodies for LGALS7
     Browse Sino Biological Cell Lysates
     cDNA Clones for LGALS7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LGALS7 antibodies
     LGALS7 proteins
     LGALS7 lysates
     Antibodies for LGALS7
     See all of Abcam's Antibodies, Kits and Proteins for LGALS7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for LGALS7




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for LGALS7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS7
     Browse SwitchGear 3'UTR luciferase reporter plasmids for LGALS7
     SwitchGear Promoter luciferase reporter plasmids for LGALS7
     ThermoFisher Antibodies for LGALS7
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LGALS7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LGALS7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LGALS7
    Customized:
     lentivirus for stable overexpression of LGALS7
     lentivirus expression plasmids for stable overexpression of LGALS7
     adenovirus for overexpression of LGALS7
     LSBio Antibodies in human, mouse, rat for LGALS7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LGALS7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4