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Aliases for LGALS7 Gene

Aliases for LGALS7 Gene

  • Galectin 7 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 7 2 3
  • P53-Induced Gene 1 Protein 4
  • LGALS7 LGALS7B 4
  • Galectin-7 3
  • LGALS7A 3
  • HKL-14 4
  • Gal-7 4
  • GAL7 3
  • PIG1 4
  • PI7 4

External Ids for LGALS7 Gene

Previous GeneCards Identifiers for LGALS7 Gene

  • GC19P039892
  • GC19P039671
  • GC19P043955
  • GC19P043971
  • GC19P043939
  • GC19M043954
  • GC19M039261
  • GC19P035727

Summaries for LGALS7 Gene

Entrez Gene Summary for LGALS7 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS7 Gene

LGALS7 (Galectin 7) is a Protein Coding gene. Diseases associated with LGALS7 include Postencephalitic Parkinson Disease and Infantile Neuroaxonal Dystrophy 1. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS7B.

UniProtKB/Swiss-Prot for LGALS7 Gene

  • Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.

Gene Wiki entry for LGALS7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS7 Gene

Genomics for LGALS7 Gene

Regulatory Elements for LGALS7 Gene

Enhancers for LGALS7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G038769 1 ENCODE dbSUPER 74.5 +3.6 3642 1.2 CTCF KLF1 MXI1 USF1 KLF17 SIN3A MAX RAD21 POLR2A ZNF143 LGALS7 RNU6-140P PAK4 ENSG00000267892 CAPN12 GC19P038763
GH19G038761 0.9 ENCODE 69.4 +10.4 10418 3.9 ATF1 PKNOX1 DMAP1 YY1 TCF12 GATA2 PAF1 ZNF263 ZNF592 SREBF1 LGALS7 CAPN12 LGALS7B GC19P038763 GC19P038739
GH19G038784 0.8 ENCODE 71.6 -11.2 -11158 0.8 JUN ZMYM3 CHD4 ZNF384 CEBPG RAD21 FOSL1 ZNF121 GATA4 ZFHX2 LGALS7 ECH1 LGALS7B
GH19G038775 1 ENCODE dbSUPER 35.6 -2.2 -2179 0.2 ZBTB21 ZNF133 FEZF1 CEBPG ZNF2 ZEB1 ZNF101 ZNF664 ZNF366 ZNF600 LGALS7 LGALS7B
GH19G038792 0.9 ENCODE dbSUPER 39.1 -19.6 -19644 1.9 CTCF PKNOX1 RFX1 BHLHE40 ZNF621 RBBP5 RAD21 ZNF121 POLR2A ZSCAN5C LGALS7 RNU6-140P EID2B LGALS7B CAPN12 GC19M038798
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LGALS7 on UCSC Golden Path with GeneCards custom track

Genomic Location for LGALS7 Gene

Chromosome:
19
Start:
38,770,968 bp from pter
End:
38,773,517 bp from pter
Size:
2,550 bases
Orientation:
Minus strand

Genomic View for LGALS7 Gene

Genes around LGALS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS7 Gene

Proteins for LGALS7 Gene

  • Protein details for LGALS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47929-LEG7_HUMAN
    Recommended name:
    Galectin-7
    Protein Accession:
    P47929
    Secondary Accessions:
    • Q6IB87

    Protein attributes for LGALS7 Gene

    Size:
    136 amino acids
    Molecular mass:
    15075 Da
    Quaternary structure:
    • Monomer.
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LGALS7 Gene

neXtProt entry for LGALS7 Gene

Post-translational modifications for LGALS7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LGALS7 Gene

Domains & Families for LGALS7 Gene

Gene Families for LGALS7 Gene

Protein Domains for LGALS7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LGALS7: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LGALS7 Gene

Function for LGALS7 Gene

Molecular function for LGALS7 Gene

GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 7
UniProtKB/Swiss-Prot Function:
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Gene Ontology (GO) - Molecular Function for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding TAS --
genes like me logo Genes that share ontologies with LGALS7: view

Phenotypes for LGALS7 Gene

genes like me logo Genes that share phenotypes with LGALS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LGALS7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS7 Gene

Localization for LGALS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS7 Gene

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS7 gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with LGALS7: view

Pathways & Interactions for LGALS7 Gene

SuperPathways for LGALS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS --
genes like me logo Genes that share ontologies with LGALS7: view

No data available for Pathways by source and SIGNOR curated interactions for LGALS7 Gene

Drugs & Compounds for LGALS7 Gene

(3) Drugs for LGALS7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-Deoxy-2-Aminogalactose Experimental Pharma Target 0
Beta-D-Glucose Experimental Pharma Target 0

(4) Additional Compounds for LGALS7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS7: view

Transcripts for LGALS7 Gene

mRNA/cDNA for LGALS7 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LGALS7 Gene

Lectin, galactoside-binding, soluble, 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS7 Gene

No ASD Table

Relevant External Links for LGALS7 Gene

GeneLoc Exon Structure for
LGALS7
ECgene alternative splicing isoforms for
LGALS7

Expression for LGALS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x20.0), Skin - Sun Exposed (Lower leg) (x15.0), and Esophagus - Mucosa (x11.0).

Protein differential expression in normal tissues from HIPED for LGALS7 Gene

This gene is overexpressed in Hair follicle (14.8), Saliva (11.0), Urinary Bladder (8.3), Esophagus (8.3), Skin (6.7), and Urine (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGALS7 Gene



Protein tissue co-expression partners for LGALS7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LGALS7 Gene:

LGALS7

SOURCE GeneReport for Unigene cluster for LGALS7 Gene:

Hs.702546

mRNA Expression by UniProt/SwissProt for LGALS7 Gene:

P47929-LEG7_HUMAN
Tissue specificity: Mainly expressed in stratified squamous epithelium.

Evidence on tissue expression from TISSUES for LGALS7 Gene

  • Skin(4.7)
  • Nervous system(4.3)
  • Heart(2.8)
  • Lung(2.8)
  • Blood(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with LGALS7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS7 Gene

Orthologs for LGALS7 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS7 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100855989 34
  • 81.23 (n)
LGALS7 35
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Lgals7 34
  • 79.17 (n)
Grifin 35
  • 27 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia LGALS7 34
  • 79.1 (n)
-- 35
  • 71 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Lgals7 34
  • 76.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lgals3l 35
  • 19 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta galectin 35
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lec-12 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
ManyToMany
CSA.123 35
  • 15 (a)
ManyToMany
Species where no ortholog for LGALS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LGALS7 Gene

ENSEMBL:
Gene Tree for LGALS7 (if available)
TreeFam:
Gene Tree for LGALS7 (if available)

Paralogs for LGALS7 Gene

(13) SIMAP similar genes for LGALS7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LGALS7: view

Variants for LGALS7 Gene

Sequence variations from dbSNP and Humsavar for LGALS7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000870390 -- 38,774,633(+) AGCCC(C/T)CTTGG upstream-variant-2KB
rs1001858294 -- 38,774,562(+) TGGCC(C/T)AGCAT upstream-variant-2KB
rs1002374261 -- 38,774,353(+) GCTCT(C/T)CTCAC upstream-variant-2KB
rs1002756687 -- 38,775,400(+) GAGAA(C/T)TGCTT upstream-variant-2KB
rs1002979312 -- 38,771,260(+) ATTCT(A/G)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS7 Gene

Variant ID Type Subtype PubMed ID
dgv3527n100 CNV gain 25217958
esv1006530 OTHER inversion 20482838
nsv1063592 CNV gain 25217958
nsv7307 OTHER inversion 18451855
nsv9719 CNV gain 18304495

Variation tolerance for LGALS7 Gene

Gene Damage Index Score: 1.06; 21.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS7 Gene

Disorders for LGALS7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LGALS7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
postencephalitic parkinson disease
  • postencephalitic parkinsonism
infantile neuroaxonal dystrophy 1
  • neurodegeneration with brain iron accumulation 2b
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS7
genes like me logo Genes that share disorders with LGALS7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS7 Gene

Publications for LGALS7 Gene

  1. Cloning, expression, and chromosome mapping of human galectin-7. (PMID: 7534301) Madsen P. … Celis J.E. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. (PMID: 7729568) Magnaldo T. … Darmon M. (Dev. Biol. 1995) 2 3 4 22 64
  3. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. (PMID: 11706006) Kuwabara I. … Liu F.T. (J. Biol. Chem. 2002) 3 4 22 64
  4. Structural basis for the recognition of carbohydrates by human galectin-7. (PMID: 9760227) Leonidas D.D. … Acharya K.R. (Biochemistry 1998) 3 4 22 64
  5. Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells. (PMID: 20382700) Demers M. … St-Pierre Y. (Am. J. Pathol. 2010) 3 22 64

Products for LGALS7 Gene

Sources for LGALS7 Gene

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