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Aliases for LGALS4 Gene

Aliases for LGALS4 Gene

  • Galectin 4 2 3 5
  • Lectin, Galactoside-Binding, Soluble, 4 2 3
  • L-36 Lactose-Binding Protein 3 4
  • Lactose-Binding Lectin 4 3 4
  • Antigen NY-CO-27 3 4
  • L36LBP 3 4
  • Gal-4 3 4
  • Galectin-4 3
  • GAL4 3

External Ids for LGALS4 Gene

Previous GeneCards Identifiers for LGALS4 Gene

  • GC19M039904
  • GC19M039683
  • GC19M043968
  • GC19M043984
  • GC19M039292
  • GC19M035739

Summaries for LGALS4 Gene

Entrez Gene Summary for LGALS4 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS4 Gene

LGALS4 (Galectin 4) is a Protein Coding gene. Diseases associated with LGALS4 include Paraneoplastic Cerebellar Degeneration and Colorectal Cancer. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS9.

UniProtKB/Swiss-Prot for LGALS4 Gene

  • Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

Gene Wiki entry for LGALS4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS4 Gene

Genomics for LGALS4 Gene

Regulatory Elements for LGALS4 Gene

Enhancers for LGALS4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G038030 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +779.1 779131 7.6 HDGF ATF1 PKNOX1 SIN3A ZNF143 ZNF207 ZNF202 ZNF263 SP3 JUNB ZNF585B ZNF383 ZNF585A ZNF793 ZNF607 ZNF570 ZNF781 ZNF573 CATSPERG LOC100631378
GH19G039558 1.4 FANTOM5 Ensembl ENCODE 5.6 -745.0 -745000 1.8 HDGF PKNOX1 FOXA2 ARID4B FEZF1 ZNF366 ZSCAN5C IKZF2 CREM ZNF362 PLEKHG2 EID2B CLC DLL3 LEUTX MED29 LGALS4 RPS16 PAF1 ZFP36
GH19G038846 1.5 ENCODE dbSUPER 5.2 -36.6 -36645 6.6 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 FBL RPS16 ENSG00000267892 EID2B LGALS7 ENSG00000269688 RN7SL566P ZFP36 RINL ACTN4
GH19G038810 1.4 ENCODE dbSUPER 5.1 -2.6 -2612 11.1 HDGF PKNOX1 ARNT SIN3A YY1 ZNF766 ZNF416 FOS ZNF263 SP3 EID2B ZNF573 MED29 LGALS7 SUPT5H FBXO17 LOC100631378 RINL ZFP36 RPS16
GH19G038834 1.3 ENCODE dbSUPER 5.3 -26.0 -26028 9.5 PKNOX1 FOXA2 SIN3A FEZF1 YY1 ZNF143 FOS ZNF548 DEK PAF1 ENSG00000267892 EID2B MED29 LGALS7 RPS16 RINL ACTN4 EID2 LGALS4 LGALS7B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LGALS4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LGALS4 Gene

Chromosome:
19
Start:
38,801,671 bp from pter
End:
38,813,544 bp from pter
Size:
11,874 bases
Orientation:
Minus strand

Genomic View for LGALS4 Gene

Genes around LGALS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS4 Gene

Proteins for LGALS4 Gene

  • Protein details for LGALS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56470-LEG4_HUMAN
    Recommended name:
    Galectin-4
    Protein Accession:
    P56470

    Protein attributes for LGALS4 Gene

    Size:
    323 amino acids
    Molecular mass:
    35941 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LGALS4 Gene

neXtProt entry for LGALS4 Gene

Post-translational modifications for LGALS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS4 Gene

Antibody Products

  • Abcam antibodies for LGALS4
  • Cloud-Clone Corp. Antibodies for LGALS4

Assay Products

  • Cloud-Clone Corp Assay Kits for LGALS4

No data available for DME Specific Peptides for LGALS4 Gene

Domains & Families for LGALS4 Gene

Gene Families for LGALS4 Gene

Protein Domains for LGALS4 Gene

Graphical View of Domain Structure for InterPro Entry

P56470

UniProtKB/Swiss-Prot:

LEG4_HUMAN :
  • Contains two homologous but distinct carbohydrate-binding domains.
Domain:
  • Contains two homologous but distinct carbohydrate-binding domains.
genes like me logo Genes that share domains with LGALS4: view

Function for LGALS4 Gene

Molecular function for LGALS4 Gene

UniProtKB/Swiss-Prot Function:
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

Gene Ontology (GO) - Molecular Function for LGALS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016936 galactoside binding IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LGALS4: view
genes like me logo Genes that share phenotypes with LGALS4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS4 Gene

Localization for LGALS4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS4 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 3
nucleus 3
mitochondrion 2
peroxisome 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LGALS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005829 cytosol TAS 9162064
GO:0005886 plasma membrane TAS 9162064
genes like me logo Genes that share ontologies with LGALS4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LGALS4 Gene

Pathways & Interactions for LGALS4 Gene

genes like me logo Genes that share pathways with LGALS4: view

Pathways by source for LGALS4 Gene

1 GeneGo (Thomson Reuters) pathway for LGALS4 Gene

Gene Ontology (GO) - Biological Process for LGALS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9162064
genes like me logo Genes that share ontologies with LGALS4: view

No data available for SIGNOR curated interactions for LGALS4 Gene

Drugs & Compounds for LGALS4 Gene

(21) Drugs for LGALS4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for LGALS4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS4: view

Transcripts for LGALS4 Gene

Unigene Clusters for LGALS4 Gene

Lectin, galactoside-binding, soluble, 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS4 Gene

No ASD Table

Relevant External Links for LGALS4 Gene

GeneLoc Exon Structure for
LGALS4
ECgene alternative splicing isoforms for
LGALS4

Expression for LGALS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS4 Gene

This gene is overexpressed in Colon - Transverse (x37.9) and Small Intestine - Terminal Ileum (x9.2).

Protein differential expression in normal tissues from HIPED for LGALS4 Gene

This gene is overexpressed in Rectum (24.7), Colon (18.6), and Fetal gut (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGALS4 Gene



Protein tissue co-expression partners for LGALS4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LGALS4 Gene:

LGALS4

SOURCE GeneReport for Unigene cluster for LGALS4 Gene:

Hs.5302

Evidence on tissue expression from TISSUES for LGALS4 Gene

  • Intestine(5)
  • Skin(4.4)
  • Liver(3.1)
  • Nervous system(2.7)
  • Stomach(2.6)
  • Kidney(2.3)
  • Pancreas(2.2)
  • Gall bladder(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with LGALS4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS4 Gene

Orthologs for LGALS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LGALS4 34 35
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia LGALS4 34 35
  • 82.46 (n)
dog
(Canis familiaris)
Mammalia LGALS4 34 35
  • 81.63 (n)
rat
(Rattus norvegicus)
Mammalia Lgals4 34
  • 78.26 (n)
mouse
(Mus musculus)
Mammalia Lgals4 34 16 35
  • 77.23 (n)
oppossum
(Monodelphis domestica)
Mammalia LGALS4 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGALS4 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LGALS4 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals4 34
  • 57.78 (n)
zebrafish
(Danio rerio)
Actinopterygii grifin 35
  • 30 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11374 35
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lec-12 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
ManyToMany
CSA.123 35
  • 29 (a)
ManyToMany
Species where no ortholog for LGALS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LGALS4 Gene

ENSEMBL:
Gene Tree for LGALS4 (if available)
TreeFam:
Gene Tree for LGALS4 (if available)

Paralogs for LGALS4 Gene

(10) SIMAP similar genes for LGALS4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LGALS4: view

Variants for LGALS4 Gene

Sequence variations from dbSNP and Humsavar for LGALS4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000185922 -- 38,807,591(+) GCCAG(A/G)CCGCC intron-variant
rs1000317875 -- 38,813,290(+) GCAGC(A/G)GAGGA upstream-variant-2KB, utr-variant-5-prime
rs1000810037 -- 38,803,985(+) GCCCA(C/T)CACCA intron-variant
rs1000926818 -- 38,809,062(+) ACCTC(A/T)GCACC intron-variant
rs1001008182 -- 38,803,338(+) GAGAG(A/G)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS4 Gene

Variant ID Type Subtype PubMed ID
dgv3527n100 CNV gain 25217958
nsv1058132 CNV loss 25217958
nsv175 OTHER inversion 15895083
nsv7307 OTHER inversion 18451855
nsv9722 CNV gain 18304495

Variation tolerance for LGALS4 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS4 Gene

Disorders for LGALS4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LGALS4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
paraneoplastic cerebellar degeneration
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS4

Genetic Association Database (GAD)
LGALS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS4
genes like me logo Genes that share disorders with LGALS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS4 Gene

Publications for LGALS4 Gene

  1. Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion. (PMID: 9162064) Huflejt M.E. … Leffler H. (J. Biol. Chem. 1997) 3 4 22 64
  2. Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer. (PMID: 9310382) Rechreche H. … Iovanna J.L. (Eur. J. Biochem. 1997) 3 4 22 64
  3. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the N-terminal carbohydrate-recognition domain of human galectin-4. (PMID: 20445255) Zimbardi A.L. … Nonato M.C. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 22 64
  4. Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells. (PMID: 19192249) Stechly L. … Huet G. (Traffic 2009) 3 22 64
  5. Gene expression profiling in sinonasal adenocarcinoma. (PMID: 19903339) Tripodi D. … Gratas-Rabbia-RAc C. (BMC Med Genomics 2009) 3 22 64

Products for LGALS4 Gene

Sources for LGALS4 Gene

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