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Aliases for LGALS4 Gene

Aliases for LGALS4 Gene

  • Lectin, Galactoside Binding Soluble 4 2 3
  • Lectin, Galactoside-Binding, Soluble, 4 2 3 5
  • L-36 Lactose-Binding Protein 3 4
  • Lactose-Binding Lectin 4 3 4
  • Antigen NY-CO-27 3 4
  • Galectin 4 2 3
  • L36LBP 3 4
  • Gal-4 3 4
  • GAL4 3

External Ids for LGALS4 Gene

Previous GeneCards Identifiers for LGALS4 Gene

  • GC19M039904
  • GC19M039683
  • GC19M043968
  • GC19M043984
  • GC19M039292
  • GC19M035739

Summaries for LGALS4 Gene

Entrez Gene Summary for LGALS4 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS4 Gene

LGALS4 (Lectin, Galactoside Binding Soluble 4) is a Protein Coding gene. Diseases associated with LGALS4 include colorectal cancer and paraneoplastic cerebellar degeneration. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LGALS9B.

UniProtKB/Swiss-Prot for LGALS4 Gene

  • Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.

Gene Wiki entry for LGALS4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS4 Gene

Genomics for LGALS4 Gene

Regulatory Elements for LGALS4 Gene

Enhancers for LGALS4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LGALS4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LGALS4 Gene

Chromosome:
19
Start:
38,801,671 bp from pter
End:
38,813,544 bp from pter
Size:
11,874 bases
Orientation:
Minus strand

Genomic View for LGALS4 Gene

Genes around LGALS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS4 Gene

Proteins for LGALS4 Gene

  • Protein details for LGALS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56470-LEG4_HUMAN
    Recommended name:
    Galectin-4
    Protein Accession:
    P56470

    Protein attributes for LGALS4 Gene

    Size:
    323 amino acids
    Molecular mass:
    35941 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for LGALS4 Gene

neXtProt entry for LGALS4 Gene

Proteomics data for LGALS4 Gene at MOPED

Post-translational modifications for LGALS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS4 Gene

Antibody Products

No data available for DME Specific Peptides for LGALS4 Gene

Domains & Families for LGALS4 Gene

Gene Families for LGALS4 Gene

Protein Domains for LGALS4 Gene

Graphical View of Domain Structure for InterPro Entry

P56470

UniProtKB/Swiss-Prot:

LEG4_HUMAN :
  • Contains two homologous but distinct carbohydrate-binding domains.
Domain:
  • Contains two homologous but distinct carbohydrate-binding domains.
  • Contains 2 galectin domains.
genes like me logo Genes that share domains with LGALS4: view

Function for LGALS4 Gene

Molecular function for LGALS4 Gene

UniProtKB/Swiss-Prot Function:
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
genes like me logo Genes that share phenotypes with LGALS4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS4 Gene

Localization for LGALS4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS4 Gene COMPARTMENTS Subcellular localization image for LGALS4 gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 3
nucleus 3
mitochondrion 2
peroxisome 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LGALS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9162064
genes like me logo Genes that share ontologies with LGALS4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LGALS4 Gene

Pathways & Interactions for LGALS4 Gene

genes like me logo Genes that share pathways with LGALS4: view

Pathways by source for LGALS4 Gene

1 GeneGo (Thomson Reuters) pathway for LGALS4 Gene

Interacting Proteins for LGALS4 Gene

Gene Ontology (GO) - Biological Process for LGALS4 Gene

None

No data available for SIGNOR curated interactions for LGALS4 Gene

Drugs & Compounds for LGALS4 Gene

(20) Drugs for LGALS4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for LGALS4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS4: view

Transcripts for LGALS4 Gene

Unigene Clusters for LGALS4 Gene

Lectin, galactoside-binding, soluble, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS4 Gene

No ASD Table

Relevant External Links for LGALS4 Gene

GeneLoc Exon Structure for
LGALS4
ECgene alternative splicing isoforms for
LGALS4

Expression for LGALS4 Gene

mRNA expression in normal human tissues for LGALS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS4 Gene

This gene is overexpressed in Colon - Transverse (x37.9) and Small Intestine - Terminal Ileum (x9.2).

Protein differential expression in normal tissues from HIPED for LGALS4 Gene

This gene is overexpressed in Rectum (24.7), Colon (18.6), and Fetal gut (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LGALS4 Gene



SOURCE GeneReport for Unigene cluster for LGALS4 Gene Hs.5302

genes like me logo Genes that share expression patterns with LGALS4: view

Protein tissue co-expression partners for LGALS4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LGALS4 Gene

Orthologs for LGALS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LGALS4 35
  • 82.46 (n)
  • 79.88 (a)
LGALS4 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LGALS4 35
  • 81.63 (n)
  • 79.57 (a)
LGALS4 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgals4 35
  • 77.23 (n)
  • 76.09 (a)
Lgals4 16
Lgals4 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGALS4 35
  • 99.28 (n)
  • 99.07 (a)
LGALS4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgals4 35
  • 78.26 (n)
  • 76.4 (a)
oppossum
(Monodelphis domestica)
Mammalia LGALS4 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGALS4 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LGALS4 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals4 35
  • 57.78 (n)
  • 56.11 (a)
zebrafish
(Danio rerio)
Actinopterygii grifin 36
  • 30 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11374 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lec-12 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
CSA.123 36
  • 29 (a)
ManyToMany
Species with no ortholog for LGALS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LGALS4 Gene

ENSEMBL:
Gene Tree for LGALS4 (if available)
TreeFam:
Gene Tree for LGALS4 (if available)

Paralogs for LGALS4 Gene

(10) SIMAP similar genes for LGALS4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LGALS4: view

Variants for LGALS4 Gene

Sequence variations from dbSNP and Humsavar for LGALS4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8106404 - 38,812,518(+) GCAGC(A/G)TCTGG reference, missense, utr-variant-5-prime
rs12977453 -- 38,804,831(+) aaaaa(A/C)caaaa intron-variant
rs7507803 -- 38,810,385(+) tgaga(A/T)ggagt intron-variant
rs66473176 -- 38,809,669(+) TTTTT(-/TT)GTAGA intron-variant
rs71165582 -- 38,803,033(+) TTTTT(-/T)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS4 Gene

Variant ID Type Subtype PubMed ID
nsv7307 OTHER Inversion 18451855
nsv911670 CNV Gain 21882294
dgv3859n71 CNV Loss 21882294
nsv175 OTHER Inversion 15895083
nsv9722 CNV Gain 18304495

Variation tolerance for LGALS4 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS4 Gene

HapMap Linkage Disequilibrium report
LGALS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS4 Gene

Disorders for LGALS4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LGALS4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
paraneoplastic cerebellar degeneration
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS4

Genetic Association Database (GAD)
LGALS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS4
genes like me logo Genes that share disorders with LGALS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS4 Gene

Publications for LGALS4 Gene

  1. Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion. (PMID: 9162064) Huflejt M.E. … Leffler H. (J. Biol. Chem. 1997) 3 4 23 67
  2. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the N-terminal carbohydrate-recognition domain of human galectin-4. (PMID: 20445255) Zimbardi A.L. … Nonato M.C. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 23
  3. Gene expression profiling in sinonasal adenocarcinoma. (PMID: 19903339) Tripodi D. … Gratas-Rabbia-RAc C. (BMC Med Genomics 2009) 3 23
  4. Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells. (PMID: 19192249) Stechly L. … Huet G. (Traffic 2009) 3 23
  5. Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8. (PMID: 18539029) Oberg C.T. … Nilsson U.J. (Bioorg. Med. Chem. Lett. 2008) 3 23

Products for LGALS4 Gene

Sources for LGALS4 Gene

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