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Aliases for LGALS3BP Gene

Aliases for LGALS3BP Gene

  • Lectin, Galactoside-Binding, Soluble, 3 Binding Protein 2 3
  • Mac-2-Binding Protein 2 3 4
  • Lectin Galactoside-Binding Soluble 3-Binding Protein 3 4
  • Basement Membrane Autoantigen P105 3 4
  • Tumor-Associated Antigen 90K 3 4
  • Serum Protein 90K 2 3
  • L3 Antigen 2 3
  • Mac-2 BP 3 4
  • MAC2BP 3 4
  • M2BP 3 4
  • Transport And Golgi Organization 10 Homolog B (Drosophila) 2
  • Transport And Golgi Organization 10 Homolog B 3
  • Galectin-3-Binding Protein 3
  • MAC-2-BP 3
  • TANGO10B 3
  • BTBD17B 3
  • CyCAP 3
  • Gp90 3
  • 90K 3

External Ids for LGALS3BP Gene

Summaries for LGALS3BP Gene

Entrez Gene Summary for LGALS3BP Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS3BP Gene

LGALS3BP (Lectin, Galactoside-Binding, Soluble, 3 Binding Protein) is a Protein Coding gene. Diseases associated with LGALS3BP include ostertagiasis and henoch-schoenlein purpura. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is BTBD17.

UniProtKB/Swiss-Prot for LGALS3BP Gene

  • Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.

Gene Wiki entry for LGALS3BP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS3BP Gene

Genomics for LGALS3BP Gene

Genomic Location for LGALS3BP Gene

Start:
78,971,238 bp from pter
End:
78,980,109 bp from pter
Size:
8,872 bases
Orientation:
Minus strand

Genomic View for LGALS3BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGALS3BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS3BP Gene

Regulatory Elements for LGALS3BP Gene

Proteins for LGALS3BP Gene

  • Protein details for LGALS3BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08380-LG3BP_HUMAN
    Recommended name:
    Galectin-3-binding protein
    Protein Accession:
    Q08380
    Secondary Accessions:
    • Q7M4S0
    • Q9UCH8
    • Q9UCH9
    • Q9UCI0

    Protein attributes for LGALS3BP Gene

    Size:
    585 amino acids
    Molecular mass:
    65331 Da
    Quaternary structure:
    • Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID.

    Three dimensional structures from OCA and Proteopedia for LGALS3BP Gene

neXtProt entry for LGALS3BP Gene

Proteomics data for LGALS3BP Gene at MOPED

Post-translational modifications for LGALS3BP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys441 and Lys474
  • Glycosylation at Asn69, Asn125, Asn192, Asn362, Asn398, Ser444, Asn551, and Asn580

No data available for DME Specific Peptides for LGALS3BP Gene

Domains for LGALS3BP Gene

Gene Families for LGALS3BP Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • BTBD :BTB/POZ domain containing

Protein Domains for LGALS3BP Gene

UniProtKB/Swiss-Prot:

LG3BP_HUMAN
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q08380
  • Contains 1 BTB (POZ) domain.:
    • Q08380
  • Contains 1 SRCR domain.:
    • Q08380
genes like me logo Genes that share domains with LGALS3BP: view

Function for LGALS3BP Gene

Molecular function for LGALS3BP Gene

GENATLAS Biochemistry: galectin 3,beta-galactoside specific lectin,associated with cancer and HIV infection,overexpressed in colorectal cancer in progression with poor prognosis and liver metastasis
UniProtKB/Swiss-Prot Function: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.

Gene Ontology (GO) - Molecular Function for LGALS3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LGALS3BP: view

Phenotypes for LGALS3BP Gene

genes like me logo Genes that share phenotypes with LGALS3BP: view

Animal Models for LGALS3BP Gene

MGI Knock Outs for LGALS3BP:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LGALS3BP Gene

Localization for LGALS3BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS3BP Gene

Secreted. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS3BP Gene COMPARTMENTS Subcellular localization image for LGALS3BP gene
Compartment Confidence
extracellular 5
nucleus 2
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LGALS3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 16502470
GO:0016020 membrane IEA --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LGALS3BP: view

Pathways for LGALS3BP Gene

SuperPathways for LGALS3BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS 8390986
GO:0006968 cellular defense response TAS 8034587
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 8390986
genes like me logo Genes that share ontologies with LGALS3BP: view

No data available for Pathways by source for LGALS3BP Gene

Compounds for LGALS3BP Gene

(2) Novoseek inferred chemical compound relationships for LGALS3BP Gene

Compound -log(P) Hits PubMed IDs
neopterin 57.9 4
lactose 32.9 4
genes like me logo Genes that share compounds with LGALS3BP: view

Transcripts for LGALS3BP Gene

Unigene Clusters for LGALS3BP Gene

Lectin, galactoside-binding, soluble, 3 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS3BP Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ·
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - - - - - - -
SP13: - -
SP14: - - - - - - - - - - - - - - - - -
SP15: - -

ExUns: 9d · 9e · 9f ^ 10a · 10b · 10c · 10d
SP1: - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: - - -
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:

Relevant External Links for LGALS3BP Gene

GeneLoc Exon Structure for
LGALS3BP
ECgene alternative splicing isoforms for
LGALS3BP

Expression for LGALS3BP Gene

mRNA expression in normal human tissues for LGALS3BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LGALS3BP Gene

SOURCE GeneReport for Unigene cluster for LGALS3BP Gene Hs.514535

mRNA Expression by UniProt/SwissProt for LGALS3BP Gene

Q08380-LG3BP_HUMAN
Tissue specificity: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
genes like me logo Genes that share expressions with LGALS3BP: view

Orthologs for LGALS3BP Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS3BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LGALS3BP 36
  • 99.2 (n)
  • 98.8 (a)
LGALS3BP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LGALS3BP 36
  • 79.87 (n)
  • 71.97 (a)
LGALS3BP 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CANT1 36
  • 81.99 (n)
  • 76.12 (a)
LGALS3BP 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgals3bp 36
  • 75.98 (n)
  • 69.77 (a)
Lgals3bp 16
Lgals3bp 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgals3bp 36
  • 76.33 (n)
  • 68.19 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8783 36
zebrafish
(Danio rerio)
Actinopterygii LGALS3BP (3 of 3) 37
  • 35 (a)
OneToMany
lgals3bpa 36
  • 49.39 (n)
  • 40.31 (a)
lgals3bpa 37
  • 34 (a)
OneToMany
lgals3bpb 37
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tango10 37
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W07A12.4 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
OneToMany
Species with no ortholog for LGALS3BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LGALS3BP Gene

ENSEMBL:
Gene Tree for LGALS3BP (if available)
TreeFam:
Gene Tree for LGALS3BP (if available)

Paralogs for LGALS3BP Gene

Paralogs for LGALS3BP Gene

genes like me logo Genes that share paralogs with LGALS3BP: view

Variants for LGALS3BP Gene

Sequence variations from dbSNP and Humsavar for LGALS3BP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11024 -- 78,971,445(-) CACCT(C/G)AGCGC utr-variant-3-prime
rs1113032 -- 78,977,257(-) GGGCC(A/G)TCTGG intron-variant
rs1114624 -- 78,977,255(-) GCCAT(A/C)TGGCT intron-variant
rs1131459 -- 78,971,493(-) CCTCT(C/T)TGCAA utr-variant-3-prime
rs1131516 -- 78,971,332(-) TTGCT(C/T)TGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LGALS3BP Gene

Variant ID Type Subtype PubMed ID
dgv3283n71 CNV Loss 21882294
nsv457917 CNV Gain 19166990
nsv908900 CNV Loss 21882294
dgv3284n71 CNV Loss 21882294
nsv523650 CNV Loss 19592680
nsv2155 CNV Insertion 18451855
nsv908903 CNV Loss 21882294
nsv470610 CNV Loss 18288195
nsv908905 CNV Gain 21882294

Relevant External Links for LGALS3BP Gene

HapMap Linkage Disequilibrium report
LGALS3BP

Disorders for LGALS3BP Gene

(1) University of Copenhagen DISEASES for LGALS3BP Gene

(22) Novoseek inferred disease relationships for LGALS3BP Gene

Disease -log(P) Hits PubMed IDs
ovarian carcinoma 39.2 2
tumors 32.7 36
cancer 29.9 27
lung carcinoma 28 5
metastasis 26.5 15

Relevant External Links for LGALS3BP

Genetic Association Database (GAD)
LGALS3BP
Human Genome Epidemiology (HuGE) Navigator
LGALS3BP
genes like me logo Genes that share disorders with LGALS3BP: view

No data available for UniProtKB/Swiss-Prot for LGALS3BP Gene

Publications for LGALS3BP Gene

  1. Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. (PMID: 8390986) Koths K. … Wang A. (J. Biol. Chem. 1993) 2 3 4 23
  2. The secreted tumor-associated antigen 90K is a potent immune stimulator. (PMID: 8034587) Ullrich A. … Natoli C. (J. Biol. Chem. 1994) 2 3 4 23
  3. Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. (PMID: 9501082) Sasaki T. … Timpl R. (EMBO J. 1998) 3 4 23
  4. The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25. (PMID: 7698018) Calabrese G. … Iacobelli S. (Cytogenet. Cell Genet. 1995) 2 3 23
  5. Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PMID: 11146440) Tinari N. … Liu F.-T. (Int. J. Cancer 2001) 3 4 23

Products for LGALS3BP Gene

Sources for LGALS3BP Gene

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