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LGALS3BP Gene

protein-coding   GIFtS: 62
GCID: GC17M076970

Lectin, Galactoside-Binding, Soluble, 3 Binding Protein

  See LGALS3BP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lectin, Galactoside-Binding, Soluble, 3 Binding Protein1 2     Transport And Golgi Organization 10 Homolog B (Drosophila)1
Mac-2-Binding Protein1 2 3     90K2
L3 Antigen1 2     BTBD17B2
Serum Protein 90K1 2     MAC-2-BP2
Basement Membrane Autoantigen P1052 3     TANGO10B2
Lectin Galactoside-Binding Soluble 3-Binding Protein2 3     Galectin-3-Binding Protein2
Mac-2 BP2 3     Transport And Golgi Organization 10 Homolog B2
Tumor-Associated Antigen 90K2 3     M2BP3
MAC2BP2 3     

External Ids:    HGNC: 65641   Entrez Gene: 39592   Ensembl: ENSG000001086797   OMIM: 6006265   UniProtKB: Q083803   

Export aliases for LGALS3BP gene to outside databases

Previous GC identifers: GC17P076798 GC17P080282 GC17M077428 GC17M077564 GC17M074478 GC17M072389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LGALS3BP Gene:
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix
interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the
human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer
(NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full
length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human
macrophage-associated lectin known as Mac-2 and also binds galectin 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for LGALS3BP Gene:
LGALS3BP (lectin, galactoside-binding, soluble, 3 binding protein) is a protein-coding gene. Diseases associated with LGALS3BP include ostertagiasis, and henoch-schoenlein purpura. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is BTBD17.

UniProtKB/Swiss-Prot: LG3BP_HUMAN, Q08380
Function: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells

Gene Wiki entry for LGALS3BP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the LGALS3BP gene promoter:
         RP58   FOXF2   Pax-5   RelA   HNF-3beta   NF-kappaB   PPAR-gamma2   ZIC2/Zic2   MRF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LGALS3BP promoter sequence
   Search Chromatin IP Primers for LGALS3BP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LGALS3BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

LGALS3BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS3BP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M076970:  view genomic region     (about GC identifiers)

Start:
76,967,320 bp from pter      End:
76,976,191 bp from pter
Size:
8,872 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LG3BP_HUMAN, Q08380 (See protein sequence)
Recommended Name: Galectin-3-binding protein precursor  
Size: 585 amino acids; 65331 Da
Subunit: Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds
LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID
1 PDB 3D structure from and Proteopedia for LGALS3BP:
1BY2 (3D)    
Secondary accessions: Q7M4S0 Q9UCH8 Q9UCH9 Q9UCI0

Explore the universe of human proteins at neXtProt for LGALS3BP: NX_Q08380

Explore proteomics data for LGALS3BP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys441, Lys474
  • Glycosylation2 at Asn69, Asn125, Asn192, Asn362, Asn398, Ser444, Asn551, Asn580
  • Modification sites at PhosphoSitePlus

  • See LGALS3BP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005558.1  
    ENSEMBL proteins: 
     ENSP00000465120   ENSP00000262776   ENSP00000467976   ENSP00000465982   ENSP00000466850  
     ENSP00000468480   ENSP00000467211   ENSP00000465729   ENSP00000468774   ENSP00000465380  
     ENSP00000466333   ENSP00000467646   ENSP00000468131   ENSP00000466318   ENSP00000468586  

    LGALS3BP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LGALS3BP

     
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    Cloud-Clone Corp. CLIAs for LGALS3BP
    eBioscience ELISAs for LGALS3BP:  
                        Human s90K/Mac-2BP Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    BTBD: BTB/POZ domain containing

    5 InterPro protein domains:
     IPR001190 SRCR
     IPR011333 BTB/POZ_fold
     IPR017448 Srcr_rcpt-rel
     IPR011705 BACK
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q08380

    ProtoNet protein and cluster: Q08380

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: LG3BP_HUMAN, Q08380
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 1 SRCR domain


    Find genes that share domains with LGALS3BP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LG3BP_HUMAN, Q08380
    Function: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells

         Genatlas biochemistry entry for LGALS3BP:
    galectin 3,beta-galactoside specific lectin,associated with cancer and HIV infection,overexpressed in colorectal
    cancer in progression with poor prognosis and liver metastasis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LGALS3BP           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lgals3bp):
     homeostasis/metabolism  immune system 

    Find genes that share phenotypes with LGALS3BP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lgals3bptm1Megt for LGALS3BP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LGALS3BP
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGALS3BP

    miRNA
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    hsa-mir-1260b (MIRT052728), hsa-mir-296-3p (MIRT038443), hsa-mir-671-5p (MIRT039290), hsa-mir-222-3p (MIRT046598), hsa-mir-1 (MIRT024048), hsa-mir-596 (MIRT007309), hsa-mir-26b-3p (MIRT038953), hsa-mir-7-5p (MIRT025918)

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    SwitchGear 3'UTR luciferase reporter plasmidLGALS3BP 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS3BP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LG3BP_HUMAN, Q08380: Secreted. Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    lysosome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space TAS8390986
    GO:0016020membrane IEA--
    GO:0031012colocalizes with extracellular matrix IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with LGALS3BP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LGALS3BP
    Interactions:

        GeneGlobe Interaction Network for LGALS3BP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for LGALS3BP (Q083802, 3 ENSP000002627764) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD22, 3, ENSP000003299674MINT-49267 I2D: score=2 STRING: ENSP00000329967
    IKBKEQ141642, 3MINT-48106 I2D: score=2 
    MAP3K1Q132332, 3MINT-48308 I2D: score=2 
    TAB2Q9NYJ82, 3MINT-49200 I2D: score=2 
    TRADDQ156282, 3MINT-49478 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS8390986
    GO:0006968cellular defense response TAS8034587
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS8390986

    Find genes that share ontologies with LGALS3BP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LGALS3BP (LG3BP)

    2 Novoseek inferred chemical compound relationships for LGALS3BP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neopterin 57.9 7 8913279 (2), 9413956 (1), 8163831 (1)
    lactose 32.9 4 9501082 (2), 11146440 (1), 18450743 (1)



    Find genes that share compounds with LGALS3BP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LGALS3BP gene: 
    NM_005567.3  

    Unigene Cluster for LGALS3BP:

    Lectin, galactoside-binding, soluble, 3 binding protein
    Hs.514535  [show with all ESTs]
    Unigene Representative Sequence: NM_005567
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000591778 ENST00000262776(uc002jwh.3 uc002jwi.3) ENST00000587311
    ENST00000586720 ENST00000587251 ENST00000588508 ENST00000588198 ENST00000589527
    ENST00000588587 ENST00000592255 ENST00000585407 ENST00000589775 ENST00000589906
    ENST00000587310 ENST00000588205 ENST00000588990 ENST00000588899 ENST00000591274

    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LGALS3BP
      QuantiTect SYBR Green Assays in human, mouse, rat LGALS3BP
      QuantiFast Probe-based Assays in human, mouse, rat LGALS3BP

    Additional mRNA sequence: 

    AK055977.1 AK057776.1 AK293183.1 AK295442.1 AK301040.1 AK301444.1 AK307665.1 BC002403.2 
    BC002998.1 BC015761.1 L13210.1 X79089.1 

    Selected DOTS entries (see all 45):

    DT.454138  DT.97822035  DT.100687362  DT.100687367  DT.99973557  DT.100687355  DT.100687347  DT.100687370 
    DT.100687312  DT.100687324  DT.100687341  DT.100687327  DT.100687345  DT.100696286  DT.100866434  DT.92045121 
    DT.100687307  DT.100687331  DT.100687339  DT.100687348  DT.92007154  DT.95366962  DT.95366993  DT.100687314 

    Selected AceView cDNA sequences (see all 1367):

    BF346142 AA430521 BG766889 BM743767 BP351241 BU179787 BM473596 AI968978 
    C00378 BQ787464 BQ691795 CB529071 CD366432 CD559078 BX098885 BM982778 
    BU146738 AA295140 BM041986 CA425508 BE793605 BU858253 BG110528 BM887762 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LGALS3BP (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ·
    SP1:                                      -     -                       -     -                                         -                                       
    SP2:                                            -                       -     -                                         -                                       
    SP3:                                      -     -                                                                       -                                       
    SP4:                                      -     -                       -     -           -     -     -                 -                                       
    SP5:                                      -     -                       -     -                                                                                 

    ExUns: 9d · 9e · 9f ^ 10a · 10b · 10c · 10d
    SP1:        -     -                           
    SP2:                                          
    SP3:                                          
    SP4:        -     -                           
    SP5:                                          


    ECgene alternative splicing isoforms for LGALS3BP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LGALS3BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTCCCTG
    LGALS3BP Expression
    About this image


    LGALS3BP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Gonad
             Primordial germ cell-like cells
    LGALS3BP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LGALS3BP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514535

    UniProtKB/Swiss-Prot: LG3BP_HUMAN, Q08380
    Tissue specificity: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine.
    Expressed by keratinocytes and fibroblasts

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS3BP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LGALS3BP gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lgals3bp1 , 5 lectin, galactoside-binding, soluble, 3 binding protein1, 5 75.98(n)1
    69.77(a)1
      11 (83.14 cM)5
    190391  NM_011150.21  NP_035280.11 
     1183927515 
    zebrafish
    (Danio rerio)
    Actinopterygii lgals3bpa1 lectin, galactoside-binding, soluble, 3 binding protein more 49.39(n)
    40.31(a)
      677742  NM_001040041.1  NP_001035130.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango106
    Transport and Golgi organization 10
    16(a)
    1 → many
    X(11614278-11617889)
    worm
    (Caenorhabditis elegans)
    Secernentea W07A12.46
    Protein W07A12.4 (W07A12.4) mRNA, complete cds
    17(a)
    1 → many
    II(9148356-9152311) WBGene00012322


    ENSEMBL Gene Tree for LGALS3BP (if available)
    TreeFam Gene Tree for LGALS3BP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LGALS3BP gene
    BTBD172  
    10 SIMAP similar genes for LGALS3BP using alignment to 13 protein entries:     LG3BP_HUMAN (see all proteins):
    LOXL2    DMBT1    HHIPL1    MSR1    SSC5D    CD6
    CD163    MARCO    CD163L1    LOXL3

    Find genes that share paralogs with LGALS3BP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LGALS3BP (see all 376)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859828531,2
    --76966851(+) TACAAA/CAATAC 1 -- ds50010--------
    rs1140193841,2
    C,F--76966873(+) AGGTAC/TGATGG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1484386481,2
    C--76966993(+) GCGAC-/AGAACAA 1 -- ds50010--------
    rs591595441,2
    C,F--76967063(+) GGGCAG/CCCGTC 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs589964431,2
    C,F--76967096(+) ACACAC/G/TGCCTG 1 -- ds50012WA 120
    rs1177712941,2
    C,F--76967348(+) CCTCAA/GTGTAA 1 -- ut311Minor allele frequency- G:0.03NA 120
    rs1466487901,2
    C--76967436(+) TCCTGG/TTGCTT 1 -- ut310--------
    rs1908524621,2
    --76967552(+) TGGTGA/GCCGGT 1 -- ut310--------
    rs31913751,2
    C--76967577(-) TTCCTC/TTCTGC 1 -- ut31 ese3 trp32Minor allele frequency- T:0.00NA 4
    rs790981711,2
    C,F--76967602(+) GGAGCC/TTGCAG 1 -- ut311Minor allele frequency- T:0.03EA 120

    HapMap Linkage Disequilibrium report for LGALS3BP (76967320 - 76976191 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for LGALS3BP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2155CNV Insertion18451855
    nsv908903CNV Loss21882294
    dgv3284n71CNV Loss21882294
    nsv908900CNV Loss21882294
    dgv3283n71CNV Loss21882294
    nsv523650CNV Loss19592680
    nsv470610CNV Loss18288195
    nsv908905CNV Gain21882294
    nsv457917CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LGALS3BP
    DNA2.0 Custom Variant and Variant Library Synthesis for LGALS3BP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600626    OMIM disorders: --

    3 diseases for LGALS3BP:    
    About MalaCards
    ostertagiasis    henoch-schoenlein purpura    strongyloidiasis

    1 disease from the University of Copenhagen DISEASES database for LGALS3BP:
    Ostertagiasis

    Find genes that share disorders with LGALS3BP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LGALS3BP gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian carcinoma 39.2 2 7989123 (1), 8737525 (1)
    tumors 32.7 45 7615355 (5), 12404290 (5), 19544526 (3), 18942707 (2) (see all 21)
    cancer 29.9 39 15492795 (4), 16245278 (3), 12404290 (3), 15547688 (2) (see all 16)
    lung carcinoma 28 8 12404290 (4), 15492795 (1)
    metastasis 26.5 19 19544526 (3), 11815981 (2), 14758079 (2), 17131321 (2) (see all 9)
    ovarian cancer 24.4 7 11205296 (3), 8895537 (2), 8737525 (1), 8439505 (1)
    virus infection 18.5 5 7582257 (1), 10198166 (1), 15231701 (1), 8095982 (1) (see all 5)
    colon cancer 17.6 3 15140826 (1), 15362030 (1), 8439505 (1)
    lung tumor 16.4 3 8024581 (1), 1919444 (1)
    cancer lung 11.9 10 15492795 (2), 15547688 (1), 12015746 (1), 15094380 (1)

    Genetic Association Database (GAD): LGALS3BP
    Human Genome Epidemiology (HuGE) Navigator: LGALS3BP (2 documents)

    Export disorders for LGALS3BP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LGALS3BP gene, integrated from 10 sources (see all 154):
    (articles sorted by number of sources associating them with LGALS3BP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted tumor-associated antigen 90K is a potent immune stimulator. (PubMed id 8034587)1, 2, 3, 9 Ullrich A.... Natoli C. (J. Biol. Chem. 1994)
    2. Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PubMed id 11146440)1, 2, 9 Tinari N....Liu F.-T. (Int. J. Cancer 2001)
    3. The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25. (PubMed id 7698018)1, 3, 9 Calabrese G....Iacobelli S. (Cytogenet. Cell Genet. 1995)
    4. Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. (PubMed id 8390986)1, 2, 9 Koths K.... Wang A. (J. Biol. Chem. 1993)
    5. Functional studies on recombinant domains of Mac-2-binding protein. (PubMed id 11867635)1, 2, 9 Hellstern S.... Engel J. (J. Biol. Chem. 2002)
    6. Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. (PubMed id 9501082)1, 2, 9 Sasaki T.... Timpl R. (EMBO J. 1998)
    7. [SNP polymorphism of LGALS3BP gene in patients with benign and malignant thyroid tumours]. (PubMed id 17091456)1, 4 A8ukieA8czuk T....Dobosz T. (Endokrynol Pol 2006)
    8. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    10. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (Mol. Cell. Proteomics 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3959 HGNC: 6564 AceView: LGALS3BP Ensembl:ENSG00000108679 euGenes: HUgn3959
    ECgene: LGALS3BP H-InvDB: LGALS3BP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LGALS3BP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LGALS3BP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LGALS3BP gene:
    Search GeneIP for patents involving LGALS3BP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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