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LGALS3 Gene(Protein Coding)

Galectin 3

GCID:
GC14P055124
GIFtS:
66
Genes Participants
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Aliases for LGALS3 Gene

Aliases for LGALS3 Gene

  • Galectin 3 2 3 5
  • Advanced Glycation End-Product Receptor 3 2 3
  • Lectin, Galactoside-Binding, Soluble, 3 2 3
  • Carbohydrate-Binding Protein 35 3 4
  • Galactose-Specific Lectin 3 3 4
  • Laminin-Binding Protein 3 4
  • IgE-Binding Protein 3 4
  • 35 KDa Lectin 3 4
  • Lectin L-29 3 4
  • GALBP 3 4
  • MAC2 3 4
  • Galactoside-Binding Protein 4
  • MAC-2 Antigen 3
  • Mac-2 Antigen 4
  • Galectin-3 3
  • LGALS2 3
  • CBP 35 4
  • CBP35 3
  • GALIG 3
  • Gal-3 4
  • GAL3 3
  • L-31 4
  • L31 3

External Ids for LGALS3 Gene

Previous HGNC Symbols for LGALS3 Gene

  • LGALS2

Previous GeneCards Identifiers for LGALS3 Gene

  • GC14P052920
  • GC14P049392
  • GC14P053586
  • GC14P054674
  • GC14P054665
  • GC14P055595
  • GC14P035758

Summaries for LGALS3 Gene

Entrez Gene Summary for LGALS3 Gene

  • This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

GeneCards Summary for LGALS3 Gene

LGALS3 (Galectin 3) is a Protein Coding gene. Diseases associated with LGALS3 include Follicular Adenoma and Papillary Carcinoma. Among its related pathways are Advanced glycosylation endproduct receptor signaling and Innate Immune System. GO annotations related to this gene include poly(A) RNA binding and chemoattractant activity. An important paralog of this gene is LGALS9.

UniProtKB/Swiss-Prot for LGALS3 Gene

  • Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Gene Wiki entry for LGALS3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS3 Gene

Genomics for LGALS3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for LGALS3 Gene

Enhancers for LGALS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G055097 2.1 FANTOM5 Ensembl ENCODE dbSUPER 40.7 -20.7 -20706 12.7 MLX DMAP1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D GLIS1 NBN LGALS3 LOC105370509 MAPK1IP1L GCH1 DLGAP5 FBXO34 ENSG00000259318 ATG14 GC14M055059 GC14M055058
GH14G055113 2.1 FANTOM5 Ensembl ENCODE dbSUPER 28.5 -0.1 -127 21.7 MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 LOC105370509 LGALS3 ATG14 WDHD1 GCH1 FBXO34 DLGAP5 SOCS4 ENSG00000259318 MAPK1IP1L
GH14G055070 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.8 -49.2 -49215 8.6 HDGF PKNOX1 WRNIP1 BRCA1 ZNF121 GATA2 ZNF143 FOS JUNB TBX21 LGALS3 LOC105370509 MAPK1IP1L FBXO34 ATG14 GC14M055058 GC14M055059
GH14G055270 1.1 ENCODE 14.6 +149.0 149023 4.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B LOC105370509 LGALS3 ENSG00000259318 RPL34P28
GH14G055084 0.8 ENCODE dbSUPER 11.6 -38.8 -38817 1.6 RFX1 HLF CUX1 ZNF652 SPI1 LOC105370509 MAPK1IP1L LGALS3 DLGAP5 GC14M055058 GC14M055059
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LGALS3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LGALS3 gene promoter:

Genomic Location for LGALS3 Gene

Chromosome:
14
Start:
55,124,110 bp from pter
End:
55,145,430 bp from pter
Size:
21,321 bases
Orientation:
Plus strand

Genomic View for LGALS3 Gene

Genes around LGALS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LGALS3 Gene

Proteins for LGALS3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LGALS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17931-LEG3_HUMAN
    Recommended name:
    Galectin-3
    Protein Accession:
    P17931
    Secondary Accessions:
    • B2RC38
    • Q16005
    • Q6IBA7
    • Q96J47

    Protein attributes for LGALS3 Gene

    Size:
    250 amino acids
    Molecular mass:
    26152 Da
    Quaternary structure:
    • Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Interacts with CD6 and ALCAM (PubMed:24945728). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.

    Three dimensional structures from OCA and Proteopedia for LGALS3 Gene

neXtProt entry for LGALS3 Gene

Protein Expression for LGALS3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LGALS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LGALS3 (galectin-3)
  • Cloud-Clone Corp. Antibodies for LGALS3

No data available for DME Specific Peptides for LGALS3 Gene

Domains & Families for LGALS3 Gene

Gene Families for LGALS3 Gene

HGNC:

Protein Domains for LGALS3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LGALS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LGALS3: view

No data available for UniProtKB/Swiss-Prot for LGALS3 Gene

Function for LGALS3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for LGALS3 Gene

GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 3 (L31),pre mRNA splicing factor
UniProtKB/Swiss-Prot Function:
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Gene Ontology (GO) - Molecular Function for LGALS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 2402511
GO:0019863 IgE binding IDA 2261464
GO:0030246 carbohydrate binding IEA --
GO:0042056 chemoattractant activity IDA 10925302
genes like me logo Genes that share ontologies with LGALS3: view
genes like me logo Genes that share phenotypes with LGALS3: view

Animal Models for LGALS3 Gene

MGI Knock Outs for LGALS3:

Animal Model Products

miRNA for LGALS3 Gene

miRTarBase miRNAs that target LGALS3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LGALS3 Gene

Localization for LGALS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS3 Gene

Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LGALS3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 2
lysosome 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for LGALS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 19706535
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 7682704
GO:0005681 spliceosomal complex IEA --
genes like me logo Genes that share ontologies with LGALS3: view

Pathways & Interactions for LGALS3 Gene

genes like me logo Genes that share pathways with LGALS3: view

Pathways by source for LGALS3 Gene

1 Cell Signaling Technology pathway for LGALS3 Gene
1 GeneGo (Thomson Reuters) pathway for LGALS3 Gene

SIGNOR curated interactions for LGALS3 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for LGALS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002548 monocyte chemotaxis IDA 10925302
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with LGALS3: view

Drugs & Compounds for LGALS3 Gene

Products:

  1. Drug

(27) Drugs for LGALS3 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Experimental Pharma Target 0
Antibiotics Pharma 0

(36) Additional Compounds for LGALS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LGALS3: view

Transcripts for LGALS3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for LGALS3 Gene

(3) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(661) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LGALS3 Gene

Lectin, galactoside-binding, soluble, 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for LGALS3 Gene

GeneLoc Exon Structure for
LGALS3
ECgene alternative splicing isoforms for
LGALS3

Expression for LGALS3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LGALS3 Gene

mRNA expression in normal human tissues for LGALS3 Gene
mRNA expression by BioGPS for LGALS3 GenemRNA expression by GTEx for LGALS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS3 Gene

This gene is overexpressed in Colon - Transverse (x5.3).

Protein differential expression in normal tissues from HIPED for LGALS3 Gene

This gene is overexpressed in Nasal epithelium (7.1) and Hair follicle (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LGALS3 Gene



Protein tissue co-expression partners for LGALS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LGALS3 Gene:

LGALS3

SOURCE GeneReport for Unigene cluster for LGALS3 Gene:

Hs.531081

mRNA Expression by UniProt/SwissProt for LGALS3 Gene:

P17931-LEG3_HUMAN
Tissue specificity: A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.

Evidence on tissue expression from TISSUES for LGALS3 Gene

  • Skin(4.9)
  • Nervous system(4.6)
  • Lung(4.5)
  • Intestine(4.1)
  • Heart(3.6)
  • Blood(3.3)
  • Muscle(3.3)
  • Thyroid gland(3.3)
  • Kidney(3.1)
  • Spleen(3.1)
  • Bone marrow(3)
  • Lymph node(3)
  • Stomach(2.7)
  • Eye(2.6)
  • Liver(2.6)
  • Pancreas(2.6)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with LGALS3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LGALS3 Gene

Orthologs for LGALS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LGALS3 34 35
  • 99.07 (n)
dog
(Canis familiaris)
 Mammalia LGALS3 34 35
  • 85.73 (n)
cow
(Bos Taurus)
 Mammalia LGALS3 34 35
  • 84.01 (n)
mouse
(Mus musculus)
 Mammalia Lgals3 34 16 35
  • 83.2 (n)
rat
(Rattus norvegicus)
 Mammalia Lgals3 34
  • 81.93 (n)
oppossum
(Monodelphis domestica)
 Mammalia LGALS3 35
  • 70 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia LGALS3 35
  • 58 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LGALS3 34 35
  • 65.07 (n)
lizard
(Anolis carolinensis)
 Reptilia LGALS3 35
  • 55 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia lgals3 34
  • 56.9 (n)
MGC75803 34
African clawed frog
(Xenopus laevis)
 Amphibia MGC52947 34
zebrafish
(Danio rerio)
 Actinopterygii si:ch211-67f24.5 34
  • 55.46 (n)
LGALS3 35
  • 31 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG11374 35
  • 9 (a)
 ManyToMany
worm
(Caenorhabditis elegans)
 Secernentea lec-12 35
  • 13 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 35 (a)
 ManyToMany
CSA.123 35
  • 19 (a)
 ManyToMany
Species where no ortholog for LGALS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LGALS3 Gene

ENSEMBL:
Gene Tree for LGALS3 (if available)
TreeFam:
Gene Tree for LGALS3 (if available)

Paralogs for LGALS3 Gene

Paralogs for LGALS3 Gene

(24) SIMAP similar genes for LGALS3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LGALS3: view

Variants for LGALS3 Gene

Sequence variations from dbSNP and Humsavar for LGALS3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000022826 -- 55,143,048(+) TTATG(G/T)TACAG intron-variant
rs1001146222 -- 55,144,500(+) ACTTA(A/C/T)GTATC intron-variant
rs1001196032 -- 55,131,229(+) TGATG(A/G)ATTGA intron-variant
rs1001304312 -- 55,134,010(+) ATTGG(C/T)GGTCC intron-variant
rs1001429120 -- 55,127,584(+) AGTGT(A/G)ATTCA upstream-variant-2KB

Variation tolerance for LGALS3 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS3 Gene

Human Gene Mutation Database (HGMD)
LGALS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LGALS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LGALS3 Gene

Disorders for LGALS3 Gene

MalaCards: The human disease database

(28) MalaCards diseases for LGALS3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
follicular adenoma
  • follicular adenoma of the thyroid gland
papillary carcinoma
  • papillary carcinoma nos
thyroid cancer
  • malignant neoplasm of thyroid gland
thyroid cancer, monmedullary, 1
  • papillary thyroid carcinoma
nodular goiter
  • goiter, nodular
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS3

Genetic Association Database (GAD)
LGALS3
Human Genome Epidemiology (HuGE) Navigator
LGALS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS3
genes like me logo Genes that share disorders with LGALS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS3 Gene

Publications for LGALS3 Gene

  1. Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. (PMID: 7682704) Lotz M.M. … Mercurio A.M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 22 64
  2. Molecular cloning and chromosomal mapping of a human galactoside- binding protein. (PMID: 2009535) Raz A. … Wolman S.R. (Cancer Res. 1991) 2 3 4 64
  3. Modulation of CD6 function through interaction with Galectin-1 and -3. (PMID: 24945728) Escoda-Ferran C. … Lozano F. (FEBS Lett. 2014) 3 4 64
  4. Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility. (PMID: 19940114) Kariya Y. … Gu J. (J. Biol. Chem. 2010) 3 22 64
  5. CD133(+) human pulmonary adenocarcinoma cells induce apoptosis of CD8(+) T cells by highly expressed galectin-3. (PMID: 20144269) Li W. … Feng Z. (Clin Invest Med 2010) 3 22 64

Products for LGALS3 Gene

  • Cloud-Clone Corp. Antibodies for LGALS3
  • Cloud-Clone Corp. Proteins for LGALS3
  • Cloud-Clone Corp Assay Kits for LGALS3

Sources for LGALS3 Gene

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