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LGALS3 Gene

protein-coding   GIFtS: 67
GCID: GC14P055595

Lectin, Galactoside-Binding, Soluble, 3


(Previous symbol: LGALS2)
  See LGALS3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lectin, Galactoside-Binding, Soluble, 31 2     Galectin 31
GALBP2 3 5     CBP352
MAC22 3 5     GAL32
LGALS21 2     GALIG2
Carbohydrate-Binding Protein 352 3     L312
Galactose-Specific Lectin 32 3     galectin-32
Laminin-Binding Protein2 3     Gal-33
Lectin L-292 3     L-313
Mac-2 Antigen2 3     CBP 353
35 KDa Lectin2 3     Galactoside-Binding Protein3
IgE-Binding Protein2 3     

External Ids:    HGNC: 65631   Entrez Gene: 39582   Ensembl: ENSG000001319817   OMIM: 1536195   UniProtKB: P179313   

Export aliases for LGALS3 gene to outside databases

Previous GC identifers: GC14P052920 GC14P049392 GC14P053586 GC14P054674 GC14P054665 GC14P035758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LGALS3 Gene:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family
have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem
repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through
the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the
extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions
including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple
transcript variants.(provided by RefSeq, Apr 2010)

GeneCards Summary for LGALS3 Gene:
LGALS3 (lectin, galactoside-binding, soluble, 3) is a protein-coding gene. Diseases associated with LGALS3 include follicular adenoma, and posterior fossa tumors. GO annotations related to this gene include carbohydrate binding and IgE binding. An important paralog of this gene is LGALS8.

UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931
Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation
by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar
epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor.
Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of
monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells

Gene Wiki entry for LGALS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LGALS3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGALS3 promoter sequence
   Search Chromatin IP Primers for LGALS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LGALS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.3   Ensembl cytogenetic band:  14q22.3   HGNC cytogenetic band: 14q22.3

LGALS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P055595:  view genomic region     (about GC identifiers)

Start:
55,590,828 bp from pter      End:
55,612,148 bp from pter
Size:
21,321 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931 (See protein sequence)
Recommended Name: Galectin-3  
Size: 250 amino acids; 26152 Da
Subunit: Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the
ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA
Selected PDB 3D structures from and Proteopedia for LGALS3 (see all 25):
1A3K (3D)        1KJL (3D)        1KJR (3D)        2NMN (3D)        2NMO (3D)        2NN8 (3D)    
Secondary accessions: B2RC38 Q16005 Q6IBA7 Q96J47

Explore the universe of human proteins at neXtProt for LGALS3: NX_P17931

Explore proteomics data for LGALS3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LGALS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001170859.1  NP_002297.2  

    ENSEMBL proteins: 
     ENSP00000451526   ENSP00000254301   ENSP00000451381  
    Reactome Protein details: P17931

    LGALS3 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for LGALS3 (Galectin-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LGALS3
    OriGene Protein Over-expression Lysate for LGALS3
    OriGene MassSpec for LGALS3
    OriGene Custom Protein Services for LGALS3
    GenScript Custom Purified and Recombinant Proteins Services for LGALS3
    Novus Biologicals LGALS3 Proteins
    Novus Biologicals LGALS3 Lysates
    Sino Biological Recombinant Protein for LGALS3
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LGALS3
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LGALS3 

    LGALS3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LGALS3
    R&D Systems Antibodies for LGALS3 (Galectin-3)
    Cell Signaling Technology (CST) Antibodies for LGALS3  (galectin-3)
    OriGene Antibodies for LGALS3
    OriGene Custom Antibody Services for LGALS3
    Novus Biologicals LGALS3 Antibodies
    Abcam antibodies for LGALS3
    Browse Antibodies at Cloud-Clone Corp.
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    LSBio Antibodies in human, mouse, rat for LGALS3

    LGALS3 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for LGALS3: (see all 2
                        Human Galectin-3 Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    LGALS: Lectins, galactoside-binding

    3 InterPro protein domains:
     IPR001079 Galectin_CRD
     IPR013320 ConA-like_subgrp
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P17931

    ProtoNet protein and cluster: P17931

    1 Blocks protein domain: IPB001079 Galectin

    UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931
    Similarity: Contains 1 galectin domain


    Find genes that share domains with LGALS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEG3_HUMAN, P17931
    Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation
    by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar
    epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor.
    Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of
    monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells

         Genatlas biochemistry entry for LGALS3:
    lectin,galactoside-beta binding,soluble 3 (L31),pre mRNA splicing factor

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19016746
    GO:0019863IgE binding IDA2261464
    GO:0030246carbohydrate binding IEA--
    GO:0042056chemoattractant activity IDA10925302
    GO:0043236laminin binding IDA2402511
         
    Find genes that share ontologies with LGALS3           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lgals3):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  renal/urinary system 
     reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with LGALS3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LGALS3: Lgals3tm1Poi Lgals3tm1Ftl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LGALS3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LGALS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LGALS3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGALS3

    miRNA
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    miRTarBase miRNAs that target LGALS3:
    hsa-mir-424-3p (MIRT003969), hsa-mir-744-5p (MIRT037600)

    Block miRNA regulation of human, mouse, rat LGALS3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LGALS3
    SwitchGear 3'UTR luciferase reporter plasmidLGALS3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LGALS3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): LGALS3 (NM_002306)
    Sino Biological Human cDNA Clone for LGALS3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS3

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    eBioscience FlowRNA Probe Sets ( VA1-10130) for LGALS3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LEG3_HUMAN, P17931: Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and
    associates with the cell surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion5
    nucleus5
    plasma membrane4
    cytosol3
    cytoskeleton2
    endosome1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA19706535
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA14961764
    GO:0005681spliceosomal complex IEA--

    Find genes that share ontologies with LGALS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LGALS3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Spinal Cord Injury
    Spinal Cord Injury
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Hedgehog signaling events mediated by Gli proteins
    Hedgehog signaling events mediated by Gli proteins
    4Cell adhesion Cell matrix glycoconjugates
    Cell adhesion Cell matrix glycoconjugates
    5AGE/RAGE pathway
    AGE/RAGE pathway


    Find genes that share SuperPaths with LGALS3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for LGALS3
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for LGALS3
        Cell adhesion Cell-matrix glycoconjugates

    3 BioSystems Pathways for LGALS3
        AGE/RAGE pathway
    Spinal Cord Injury
    Hedgehog signaling events mediated by Gli proteins


    1 Reactome Pathway for LGALS3
        Advanced glycosylation endproduct receptor signaling


        Pathway & Disease-focused RT2 Profiler PCR Arrays including LGALS3: 
              Nephrotoxicity in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LGALS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LGALS3 (P179311, 2, 3 ENSP000002543014) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183214Q299831, 2, 3EBI-1170392,EBI-1031130 MINT-8214455 MINT-8214577 I2D: score=1 
    ENSG00000235233Q299831, 2, 3EBI-1170392,EBI-1031130 MINT-8214455 MINT-8214577 I2D: score=1 
    MICAQ299831, 2, 3EBI-1170392,EBI-1031130 MINT-8214455 MINT-8214577 I2D: score=1 
    LGALS3BPQ083803, ENSP000002627764I2D: score=3 STRING: ENSP00000262776
    GEMIN4P576783, ENSP000003217064I2D: score=2 STRING: ENSP00000321706
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0002548monocyte chemotaxis IDA10925302
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0030154cell differentiation ----

    Find genes that share ontologies with LGALS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LGALS3 (LEG3)

    1 DrugBank Compound for LGALS3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for LGALS3 gene (see all 61)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetyllactosamine 79.9 26 18725453 (2), 18949555 (2), 15701008 (2), 1386213 (1) (see all 21)
    c(yigsr)3-nh2 77.6 2 7768944 (1), 9539159 (1)
    lactose 76 76 8020591 (5), 19641853 (3), 10745086 (2), 10558859 (2) (see all 46)
    gal(beta1-3)galnac 56.3 1 19690136 (1)
    galactose 49.6 14 11434930 (2), 9466664 (1), 16210905 (1), 8012932 (1) (see all 13)
    allergens 38.7 5 16210905 (1), 17015148 (1), 9363906 (1), 10103045 (1) (see all 5)
    polysaccharide 36.8 22 12701754 (2), 18216021 (2), 17176047 (2), 16210905 (1) (see all 13)
    matrigel 36.2 7 8647922 (2), 14644168 (2), 7593320 (1), 16080502 (1)
    pectin 35.6 6 18832596 (2), 19556244 (1), 17786185 (1), 16685077 (1) (see all 5)
    paraffin 21.7 7 9084856 (2), 12649736 (1), 16184379 (1), 16405409 (1) (see all 5)



    Find genes that share compounds with LGALS3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LGALS3 gene (2 alternative transcripts): 
    NM_001177388.1  NM_002306.3  

    Unigene Cluster for LGALS3:

    Lectin, galactoside-binding, soluble, 3
    Hs.531081  [show with all ESTs]
    Unigene Representative Sequence: AB209391
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553493 ENST00000254301(uc001xbr.3 uc021rtj.1) ENST00000553755
    ENST00000554715 ENST00000556438 ENST00000556322 ENST00000556263
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): LGALS3 (NM_002306)
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat LGALS3
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10130) for LGALS3 

    Additional mRNA sequence: 

    AB006780.1 AB209391.1 AK091776.1 AK314929.1 BC001120.2 BC053667.1 BC068068.1 BC128253.1 
    BC128403.1 BX161455.1 CR456897.1 CR542097.1 M35368.1 M36682.1 M57710.1 M64303.1 
    NR_003225.2 S59012.1 

    23 DOTS entries:

    DT.449319  DT.100760272  DT.95337105  DT.100886325  DT.120786489  DT.92459512  DT.40309720  DT.100008668 
    DT.95302008  DT.40305029  DT.100039271  DT.120786547  DT.100018791  DT.100829813  DT.100886322  DT.100886326 
    DT.120786448  DT.120786849  DT.92459505  DT.92459510  DT.99971636  DT.100841837  DT.91870643 

    Selected AceView cDNA sequences (see all 661):

    S59012 BU191587 BE349505 BQ271145 CD723052 AA887470 BQ681859 CR611593 
    AA242885 CR592906 BU161395 CF528537 CR599127 AI355088 CA449881 AU076446 
    CA308862 BU681070 BU157379 AA418153 BC001120 BQ674796 BQ676692 BU194504 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LGALS3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                      -         
    SP2:                                                
    SP3:              -                                 
    SP4:                                                


    ECgene alternative splicing isoforms for LGALS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LGALS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACTGTGA
    LGALS3 Expression
    About this image


    LGALS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Stylopod
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
    LGALS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LGALS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531081

    UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931
    Tissue specificity: A major expression is found in the colonic epithelium. It is also abundant in the activated
    macrophages. Expressed in fetal membranes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LGALS3: 
              Nephrotoxicity in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LGALS3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lgals31 , 5 lectin, galactose binding, soluble 31, 5 83.2(n)1
    85.66(a)1
      14 (24.60 cM)5
    168541  NM_001145953.11  NP_001139425.11 
     473677515 
    chicken
    (Gallus gallus)
    Aves LGALS31 lectin, galactoside-binding, soluble, 3 65.07(n)
    66.09(a)
      373917  NM_214591.1  NP_999756.1 
    lizard
    (Anolis carolinensis)
    Reptilia LGALS36
    lectin, galactoside-binding, soluble, 3
    55(a)
    1 ↔ 1
    GL343325.1(191139-200162)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC529472 similar to lectin, galactose binding, soluble 3 72.45(n)    AB080020.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-67f24.51 si:ch211-67f24.5 55.46(n)
    50.22(a)
      557373  XM_699180.6  XP_704272.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113746
    --
    9(a)
    many ↔ many
    2L(76348-77783)
    worm
    (Caenorhabditis elegans)
    Secernentea lec-126
    Protein LEC-12, isoform b
    13(a)
    1 → many
    V(204382-209757) WBGene00017080


    ENSEMBL Gene Tree for LGALS3 (if available)
    TreeFam Gene Tree for LGALS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LGALS3 gene
    LGALS82  LGALS92  LGALSL2  LGALS9C2  LGALS72  LGALS7B2  LGALS42  LGALS122  
    LGALS9B2  
    Selected SIMAP similar genes for LGALS3 using alignment to 5 protein entries:     LEG3_HUMAN (see all proteins) (see all similar genes):
    SUN3    MKRN1    ATL2    BUB1B    CNOT2    COX7A2
    GNPTAB    C12orf23    KLHDC1    UTY    ECD    GALK2
    FAM3A    DAPK2    NSD1    LGALS9    LGALS7    LGALS7B

    Find genes that share paralogs with LGALS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LGALS3 (see all 428)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467116981,2
    --36577376(+) TTTTTA/GCGCTT 2 -- us2k10--------
    rs1403454491,2
    --36577377(+) TTTTAC/TGCTTA 2 -- us2k10--------
    rs2000453711,2
    C--36577389(+) CTTAG-/AAAAGG 2 -- us2k10--------
    rs1812727931,2
    --36577408(+) TTTGGA/GTTGGG 2 -- us2k10--------
    rs1853231431,2
    --36577539(+) ATGTAA/CAAGTA 2 -- us2k10--------
    rs71595301,2
    C--36577711(+) TTCTTA/TTTACC 2 -- us2k13Minor allele frequency- T:0.36WA CSA 122
    rs714126661,2
    C,F--36577745(+) CACTCC/TTGGCC 2 -- us2k12Minor allele frequency- T:0.02NA 122
    rs1884778181,2
    --36577817(+) TCCTTC/TGGGTG 2 -- us2k10--------
    rs71605231,2
    C,F,A,H--36577920(+) AACTTT/GCATAA 2 -- us2k123Minor allele frequency- G:0.39NS EA NA WA CSA 2350
    rs1809360051,2
    --36577949(+) GTGACC/TTCTAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for LGALS3 (55590828 - 55612148 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LGALS3: --
    Human Gene Mutation Database (HGMD): LGALS3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LGALS3
    DNA2.0 Custom Variant and Variant Library Synthesis for LGALS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153619    OMIM disorders: --

    Selected diseases for LGALS3 (see all 21):    
    About MalaCards
    follicular adenoma    posterior fossa tumors    adult astrocytic tumour    chordoid meningioma
    polymorphous low-grade adenocarcinoma    multicystic dysplastic kidney    histiocytic sarcoma    oligodendroglioma
    anaplastic oligodendroglioma    myxopapillary ependymoma    chordoma    papillary carcinoma
    venezuelan equine encephalitis    cholangiocarcinoma    encephalitis    goiter
    astrocytoma    papillary thyroid carcinoma    pilocytic astrocytoma    thyroid cancer

    5 diseases from the University of Copenhagen DISEASES database for LGALS3:
    Thyroid cancer     Follicular adenoma     Adenoma     Carcinoma
    Goiter

    Find genes that share disorders with LGALS3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LGALS3 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenoma follicular 85.5 41 15500653 (4), 14575419 (2), 10357421 (2), 17308358 (2) (see all 24)
    thyroid nodule 79.8 58 16438854 (7), 17725102 (5), 17868400 (4), 18495537 (3) (see all 25)
    carcinoma papillary 78.6 56 15500653 (3), 15487449 (3), 16722927 (3), 12370115 (3) (see all 31)
    thyroid papillary carcinoma 76.8 60 11251175 (4), 12746563 (3), 17597183 (3), 18460740 (3) (see all 27)
    thyroid neoplasms 71.7 17 18299472 (2), 10821488 (2), 12657934 (2), 19826479 (1) (see all 12)
    thyroid carcinoma 68.4 42 11903601 (3), 18657294 (3), 18341829 (2), 16831319 (2) (see all 26)
    thyroid follicular carcinoma 68.3 10 14575419 (1), 18341829 (1), 10996713 (1), 11701669 (1) (see all 8)
    carcinoma anaplastic 67.8 9 10357421 (2), 9072007 (1), 14558920 (1), 17001889 (1) (see all 6)
    thyroid adenoma 67.4 11 7677193 (3), 16552965 (2), 14575419 (1), 10357421 (1) (see all 7)
    thyroid cancer 65.6 42 20363921 (4), 10357421 (3), 16438854 (3), 9072007 (2) (see all 22)

    Genetic Association Database (GAD): LGALS3
    Human Genome Epidemiology (HuGE) Navigator: LGALS3 (7 documents)

    Export disorders for LGALS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LGALS3 gene, integrated from 10 sources (see all 884):
    (articles sorted by number of sources associating them with LGALS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal mapping of a human galactoside- binding protein. (PubMed id 2009535)1, 2, 3 Raz A.... Wolman S.R. (Cancer Res. 1991)
    2. Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. (PubMed id 7682704)1, 2, 9 Lotz M.M.... Mercurio A.M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    3. The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter. (PubMed id 9439577)1, 2, 9 Kadrofske M.M.... Wang J.L. (Arch. Biochem. Biophys. 1998)
    4. [Polymorphism on codon 98 of the galectin-3 gene is not associated to benign and malignant thyroid tumors]. (PubMed id 17221114)1, 4, 9 Martins L....Kimura E.T. (Arq Bras Endocrinol Metabol 2006)
    5. Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen. (PubMed id 2022338)1, 2, 9 Oda Y.... Barondes S.H. (Gene 1991)
    6. Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms. (PubMed id 2261464)1, 2, 9 Robertson M.W.... Liu F.-T. (Biochemistry 1990)
    7. DDOST, PRKCSH and LGALS3, which encode AGE-receptors 1, 2 and 3, respectively, are not associated with diabetic nephropathy in type 1 diabetes. (PubMed id 20490454)1, 4 Hoverfelt A....Wessman M. (Diabetologia 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. (PubMed id 15181153)1, 2 Fukushi J.... Stallcup W.B. (Mol. Biol. Cell 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3958 HGNC: 6563 AceView: LGALS3 Ensembl:ENSG00000131981 euGenes: HUgn3958
    ECgene: LGALS3 H-InvDB: LGALS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LGALS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LGALS3 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00118

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LGALS3 gene:
    Search GeneIP for patents involving LGALS3

    Licensable Technologies for LGALS3 gene:
     Tufts University:  Use of Galectins to treat dry eye syndrome    (see all 2)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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