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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LGALS3 Gene

protein-coding GIFtS: 68
GCID: GC14P055595

lectin, galactoside-binding, soluble, 3

(Previous symbol: LGALS2)

Explore 128 diseases affiliated with
LGALS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lectin, Galactoside-Binding, Soluble, 3¹ ²		IgE-Binding Protein² ³
GALBP² ³ ⁵		MAC-2¹
MAC2² ³ ⁵		CBP35²
GALIG¹ ²		GAL3²
LGALS2¹ ²		L31²
Carbohydrate-Binding Protein 35² ³		Galectin-3¹
Galactose-Specific Lectin 3² ³		Gal-3³
Laminin-Binding Protein² ³		L-31³
Lectin L-29² ³		CBP 35³
Mac-2 Antigen² ³		Galactoside-Binding Protein³
35 KDa Lectin² ³

External Ids:	HGNC: 6563¹	Entrez Gene: 3958²	Ensembl: ENSG00000131981⁷	OMIM: 153619⁵	UniProtKB: P17931³

Export aliases for LGALS3 gene to outside databases

Previous GC identifers: GC14P052920 GC14P049392 GC14P053586 GC14P054674 GC14P054665 GC14P035758

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LGALS3:

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have

an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat

domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal

domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the

cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate

immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.(provided by

RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931

Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by

CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar

epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor.

Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes

macrophages, opsonization of apoptotic neutrophils, and activation of mast cells

Gene Wiki entry for LGALS3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LGALS3 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LGALS3 promoter sequence

Search SABiosciences Chromatin IP Primers for LGALS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGALS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.3 Ensembl cytogenetic band: 14q22.3 HGNC cytogenetic band: 14q22.3

LGALS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P055595: view genomic region (about GC identifiers)

Start:	55,590,828 bp from pter	End:	55,612,148 bp from pter
Size:	21,321 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931 (See protein sequence)

Recommended Name: Galectin-3

Size: 250 amino acids; 26152 Da

Subunit: Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3,

ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA

Subcellular location: Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates

with the cell surface

6/17 PDB 3D structures from and Proteopedia for LGALS3 (see all 17):

1A3K (3D)

1KJL (3D)

1KJR (3D)

2NMN (3D)

2NMO (3D)

2NN8 (3D)

Secondary accessions: B2RC38 Q16005 Q6IBA7 Q96J47

Explore the universe of human proteins at neXtProt for LGALS3: NX_P17931

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P17931

LGALS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001170859.1 NP_002297.2

ENSEMBL proteins:

ENSP00000451526 ENSP00000254301 ENSP00000451381

Reactome Protein details: P17931
Human Recombinant Protein Products:

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	Novus Biologicals LGALS3 Proteins Novus Biologicals LGALS3 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for LGALS3
	Uscn Proteins for LGALS3

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005634	nucleus	IDA	14961764
GO:0005681	spliceosomal complex	IEA	--
GO:0005737	cytoplasm	IDA	14961764
GO:0005743	mitochondrial inner membrane	IDA	19016746

LGALS3 for ontologies About GeneDecksing

LGALS3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LGALS3
	R&D Systems Antibodies for LGALS3 (Galectin-3)
	OriGene Antibodies (see all 7): LGALS3 OriGene Custom Antibody Services for LGALS3
	GenScript Custom Superior Antibodies Services for LGALS3
	Novus Biologicals LGALS3 Antibodies
	Abcam antibodies for LGALS3
	Uscn Antibodies for LGALS3
	ThermoFisher Antibody for LGALS3

Assay Products for LGALS3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for LGALS3 (Galectin-3) (see all)
	GenScript Custom Assay Services for LGALS3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LGALS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LGALS3 for domains About GeneDecksing

4 InterPro domains/families:

IPR001079 Galectin_CRD

IPR013320 ConA-like_subgrp

IPR015534 Galectin_3

IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry P17931

ProtoNet protein and cluster: P17931

1 Blocks protein family: IPB001079 Galectin

UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931

Similarity: Contains 1 galectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931

Function: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by

CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar

epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor.

Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes

macrophages, opsonization of apoptotic neutrophils, and activation of mast cells

Genatlas biochemistry entry for LGALS3:

lectin,galactoside-beta binding,soluble 3 (L31),pre mRNA splicing factor

miRNA Products:		miRTarBase miRNAs that target LGALS3: hsa-mir-424 (MIRT003969)

		OriGene 3'-UTR Clone: LGALS3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS3
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LGALS3
		SwitchGear 3'UTR luciferase reporter plasmid: LGALS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LGALS3 (see all 7) OriGene shRNA RFP: LGALS3 OriGene siRNA: LGALS3
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LGALS3

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		GenScript: all cDNA clones in your preferred vector (see all 2): LGALS3 (NM_002306)
		Sino Biological Human cDNA Clone for LGALS3
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LGALS3
		Search LifeMap BioReagents cell lines for LGALS3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19016746
GO:0019863	IgE binding	IEA	--
GO:0030246	carbohydrate binding	IEA	--

LGALS3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for LGALS3: Lgals3^tm1Poi Lgals3^tm1Ftl
     13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lgals3):

cardiovascular system	cellular	digestive/alimentary	hematopoietic system	homeostasis/metabolism
immune system	integument	mortality/aging	nervous system	renal/urinary system
reproductive system	respiratory system	skeleton

LGALS3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

Immune System

Immune System

1.00

Innate Immune System

0.46

AGE/RAGE pathway

AGE/RAGE pathway

1.00

Hedgehog signaling events mediated by Gli proteins

Hedgehog signaling events mediated by Gli proteins

1.00

Advanced glycosylation endproduct receptor signaling

Advanced glycosylation endproduct receptor signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for LGALS3

Cell adhesion Cell-matrix glycoconjugates

1 GeneGo (Thomson Reuters) Pathway for LGALS3

Cell adhesion Cell-matrix glycoconjugates

2 BioSystems Pathways for LGALS3

	AGE/RAGE pathway
	Hedgehog signaling events mediated by Gli proteins

3 Reactome Pathways for LGALS3

	Advanced glycosylation endproduct receptor signaling
	Immune System
	Innate Immune System

LGALS3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LGALS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/70 Interacting proteins for LGALS3 (P17931^{2, 3} ENSP00000254301⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MICA	Q29983²^,³	MINT-8214455 MINT-8214577 I2D: score=1
LGALS3BP	Q08380³, ENSP00000262776⁴	I2D: score=3 STRING: ENSP00000262776
GEMIN4	P57678³, ENSP00000321706⁴	I2D: score=2 STRING: ENSP00000321706
LGALS1	P09382³, ENSP00000215909⁴	I2D: score=2 STRING: ENSP00000215909
MMP2	P08253³, ENSP00000219070⁴	I2D: score=2 STRING: ENSP00000219070

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IEA	--
GO:0006397	mRNA processing	IEA	--
GO:0008380	RNA splicing	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0030198	extracellular matrix organization	IEA	--

LGALS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LGALS3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LGALS3

1 DrugBank Compound for LGALS3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide	--	--	target	--	17139284 17016423 10592235

10/61 Novoseek chemical compound relationships for LGALS3 gene (see all 61) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
n-acetyllactosamine	79.9	26	18725453 (2), 18949555 (2), 15701008 (2), 1386213 (1) (see all 21)
c(yigsr)3-nh2	77.6	2	7768944 (1), 9539159 (1)
lactose	76	76	8020591 (5), 19641853 (3), 10745086 (2), 10558859 (2) (see all 46)
gal(beta1-3)galnac	56.3	1	19690136 (1)
galactose	49.6	14	11434930 (2), 9466664 (1), 16210905 (1), 8012932 (1) (see all 13)
allergens	38.7	5	16210905 (1), 17015148 (1), 9363906 (1), 10103045 (1) (see all 5)
polysaccharide	36.8	22	12701754 (2), 18216021 (2), 17176047 (2), 16210905 (1) (see all 13)
matrigel	36.2	7	8647922 (2), 14644168 (2), 7593320 (1), 16080502 (1)
pectin	35.6	6	18832596 (2), 19556244 (1), 17786185 (1), 16685077 (1) (see all 5)
paraffin	21.7	7	9084856 (2), 12649736 (1), 16184379 (1), 16405409 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about LGALS3 / LEG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LGALS3 gene (2 alternative transcripts):

NM_001177388.1 NM_002306.3

Unigene Cluster for LGALS3:

Lectin, galactoside-binding, soluble, 3

Hs.531081 [show with all ESTs]

Unigene Representative Sequence: AB209391

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000553493 ENST00000254301(uc001xbr.3 uc021rtj.1) ENST00000553755

ENST00000554715 ENST00000556438 ENST00000556322 ENST00000556263

miRNA Products:		OriGene 3'-UTR Clone: LGALS3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS3
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LGALS3
		SwitchGear 3'UTR luciferase reporter plasmid: LGALS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LGALS3 (see all 7) OriGene shRNA RFP: LGALS3 OriGene siRNA: LGALS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LGALS3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LGALS3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LGALS3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS3

Additional cDNA sequence:

AB006780.1 AB209391.1 AK091776.1 AK314929.1 BC001120.2 BC053667.1 BC068068.1 BC128253.1

BC128403.1 BX161455.1 CR456897.1 CR542097.1 M35368.1 M36682.1 M57710.1 M64303.1

NR_003225.2 S59012.1

23 DOTS entries:

DT.449319 DT.100760272 DT.95337105 DT.100886325 DT.120786489 DT.92459512 DT.40309720 DT.100008668

DT.95302008 DT.40305029 DT.100039271 DT.120786547 DT.100018791 DT.100829813 DT.100886322 DT.100886326

DT.120786448 DT.120786849 DT.92459505 DT.92459510 DT.99971636 DT.100841837 DT.91870643

24/661 AceView cDNA sequences (see all 661):

AA330845 AI355088 CB161162 BU185352 BU155739 AA102237 AL701812 CA308862

AU076446 BU617415 BM768380 BQ680123 BQ681859 CD723052 BM788194 CA449881

AI708067 BE384253 BU538529 BU538879 AA417983 CA306287 BU944102 BX377896

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for LGALS3 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7
SP1:													-
SP2:
SP3:					-
SP4:

ECgene alternative splicing isoforms for LGALS3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LGALS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCACTGTGA

About this image

LGALS3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Selective marker (cell-identifying gene)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Bone

Zeugopod Epiphyseal End

Bone, Cartilage

Ovary

Ovarian Somatic Cells

Ovary

Placenta

Chorioallantoic Placenta

Extraembryonic Angioblasts

Endothelium

Bone

Mandibular Process

Bone

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Embryoid bodies (Two-step protocol fo...)

See LGALS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LGALS3

SOURCE GeneReport for Unigene cluster: Hs.531081

UniProtKB/Swiss-Prot: LEG3_HUMAN, P17931

Tissue specificity: A major expression is found in the colonic epithelium. It is also abundant in the activated

macrophages

SABiosciences Expression via Pathway-Focused PCR Arrays including LGALS3:

Nephrotoxicity in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

T-Cell Anergy & Immune Tolerance in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LGALS3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LGALS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LGALS3 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LGALS3¹	lectin, galactoside-binding, soluble, 3	62.64(n) 61.67(a)		373917 NM_214591.1 NP_999756.1
lizard (Anolis carolinensis)	Reptilia	LGALS3⁶	--	57(a)	1 ↔ 1	GL343325.1(191144-200162)
African clawed frog (Xenopus laevis)	Amphibia	MGC52947²	similar to lectin, galactose binding, soluble 3	72.45(n)		AB080020.1
zebrafish (Danio rerio)	Actinopterygii	si:ch211-67f24.5¹	si:ch211-67f24.5	54.67(n) 48.44(a)		557373 XM_699180.5 XP_704272.2
fruit fly (Drosophila melanogaster)	Insecta	CG11374⁶ galectin⁶	galectin	9(a) 9(a)	possible ortholog possible ortholog	2L(76348-77783) 2L(71757-76211)
worm (Caenorhabditis elegans)	Secernentea	lec-2⁶ lec-1⁶ (see all 6)	32 kDa beta-galactoside-binding lectin (see all 6)	4(a) 17(a) (see all 6)	many ↔ many many ↔ many (see all 6)	II(10009547-10016001) II(13195479-13199533)

ENSEMBL Gene Tree for LGALS3 (if available)
TreeFam Gene Tree for LGALS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LGALS3 gene

LGALS8² LGALS9² LGALS9C² LGALS7² LGALSL² LGALS7B² LGALS4² LGALS12²

LGALS9B²

18/23 SIMAP similar genes for LGALS3 using alignment to 5 protein entries: LEG3_HUMAN (see all proteins) (see all similar genes):

SUN3 MKRN1 ATL2 BUB1B CNOT2 COX7A2

GNPTAB C12orf23 KLHDC1 UTY GALK2 FAM3A

DAPK2 NSD1 LGALS9 LGALS7 LGALS7B LGALS2

LGALS3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71412666^1,2	C,	--	35756987(+)	`CACTCC/TTGGCC`	2	--	us2k¹		2		NA	122
rs77222245^1,2	C,F,	--	35757256(+)	`TTCAAG/ATTTAT`	2	--	us2k¹		4		NA EA	244
rs75490731^1,2	F,	--	35757900(+)	`CAAGGC/TCTCCA`	2	--	us2k¹		1		NA	120
rs3742566^1,2	C,	--	35758441(+)	`GTGTCT/AGGCCG`	2	--	us2k¹ tfbs³		5		NA WA	244
rs8012397^1,2	C,F,A,H,	--	35758824(+)	`TGATTA/CTCGAG`	2	--	int¹		20		NS EA NA WA CSA	2328
rs10149038^1,2	C,F,H,	--	35759707(+)	`GCGCAA/GTGAGG`	2	--	int¹		12		NS EA NA WA	1564
rs61160305^1,2	C,	--	35759817(+)	`CTACTT/CGGGCA`	2	--	int¹		2		WA	120
rs61677952^1,2	C,	--	35760073(+)	`GGTGG-/TGGGGG`	2	--	int¹		0	--	--	--	--
rs78793419^1,2	C,	--	35761219(+)	`AATGGG/TCTTTC`	2	--	int¹		2		NA	122
rs74669285^1,2	F,	--	35761441(+)	`CATAGT/GGCAGC`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for LGALS3 (55590828 - 55612148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LGALS3: --
Human Gene Mutation Database (HGMD): LGALS3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LGALS3

DNA2.0 Custom Variant and Variant Library Synthesis for LGALS3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LGALS3 for disorders           About GeneDecksing

OMIM gene information: 153619    OMIM disorders: --

20/128 diseases for LGALS3 (see all 128):    About MalaCards

polymorphous low-grade adenocarcinoma adult astrocytic tumour venezuelan equine encephalitis smooth muscle tumor

diffuse large b-cell lymphoma central nervous system lymphoma myxopapillary ependymoma non-small cell lung carcinoma

b-cell lymphomas anaplastic oligodendroglioma pilocytic astrocytoma anaplastic large cell lymphoma

parathyroid adenoma food allergy chordoid meningioma bladder transitional cell carcinoma

thyroiditis goiter anaplastic astrocytoma transitional cell carcinoma

5 diseases from the University of Copenhagen DISEASES database for LGALS3:

Thyroid cancer Follicular adenoma Adenoma Carcinoma

Goiter

10/95 Novoseek disease relationships for LGALS3 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenoma follicular	85.5	41	15500653 (4), 14575419 (2), 10357421 (2), 17308358 (2) (see all 24)
thyroid nodule	79.8	58	16438854 (7), 17725102 (5), 17868400 (4), 18495537 (3) (see all 25)
carcinoma papillary	78.6	56	15500653 (3), 15487449 (3), 16722927 (3), 12370115 (3) (see all 31)
thyroid papillary carcinoma	76.8	60	11251175 (4), 12746563 (3), 17597183 (3), 18460740 (3) (see all 27)
thyroid neoplasms	71.7	17	18299472 (2), 10821488 (2), 12657934 (2), 19826479 (1) (see all 12)
thyroid carcinoma	68.4	42	11903601 (3), 18657294 (3), 18341829 (2), 16831319 (2) (see all 26)
thyroid follicular carcinoma	68.3	10	14575419 (1), 18341829 (1), 10996713 (1), 11701669 (1) (see all 8)
carcinoma anaplastic	67.8	9	10357421 (2), 9072007 (1), 14558920 (1), 17001889 (1) (see all 6)
thyroid adenoma	67.4	11	7677193 (3), 16552965 (2), 14575419 (1), 10357421 (1) (see all 7)
thyroid cancer	65.6	42	20363921 (4), 10357421 (3), 16438854 (3), 9072007 (2) (see all 22)

Human Genome Epidemiology (HuGE) Navigator: LGALS3 (7 documents)

Export disorders for LGALS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LGALS3 gene, integrated from 9 sources (see all 829):
(articles sorted by number of sources associating them with LGALS3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and chromosomal mapping of a human galactoside- binding protein. (PubMed id 2009535)^{1, 2, 3} Raz A.... Wolman S.R. (1991)
Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. (PubMed id 7682704)^{1, 2, 9} Lotz M.M.... Mercurio A.M. (1993)
The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter. (PubMed id 9439577)^{1, 2, 9} Kadrofske M.M.... Wang J.L. (1998)
Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen. (PubMed id 2022338)^{1, 2, 9} Oda Y.... Barondes S.H. (1991)
Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms. (PubMed id 2261464)^{1, 2, 9} Robertson M.W.... Liu F.-T. (1990)
NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. (PubMed id 15181153)^{1, 2} Fukushi J.... Stallcup W.B. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution. (PubMed id 9582341)^{1, 2} Seetharaman J....Rini J.M. (1998)
Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. (PubMed id 9501082)^{1, 2} Sasaki T.... Timpl R. (1998)
Galectins. Structure and function of a large family of animal lectins. (PubMed id 8063692)^{1, 3} Barondes S.H....Leffler H. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3958	HGNC: 6563	AceView: LGALS3	Ensembl:ENSG00000131981	euGenes: HUgn3958
ECgene: LGALS3	H-InvDB: LGALS3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LGALS3	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00118

Intellectual Property for LGALS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LGALS3 gene:
Search GeneIP for patents involving LGALS3

Licensable Technologies for LGALS3 gene:

Tufts University:

Use of Galectins to treat dry eye syndrome

(see all 2)

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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LGALS3 Gene

lectin, galactoside-binding, soluble, 3

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LGALS3 (Gene Symbol)
Lectin, Galactoside-Binding, Soluble, 3
GALBP
MAC2
GALIG
LGALS2
Carbohydrate-Binding Protein 35
Galactose-Specific Lectin 3
Laminin-Binding Protein
Lectin L-29
Mac-2 Antigen
35 KDa Lectin
IgE-Binding Protein
MAC-2
CBP35
GAL3
L31
Galectin-3
Gal-3
L-31
CBP 35
Galactoside-Binding Protein

Lymphoma Large Cell
Anaplastic Oligodendroglioma
Leukemia T-Cell
Pituitary Tumors
THYROID CARCINOMA ANAPLASTIC
Carcinoma Basal Cell
Oncocytoma
THYROID FOLLICULAR CARCINOMA
Dermatitis Atopic
Allergic Reaction
Thyroid Nodule
aggressiveness
COLON CARCINOMA
allergy
Encephalitis Tick-Borne
PARATHYROID ADENOMA
Anaplastic Astrocytoma
Lymphoma Follicular
Atherosclerosis
Ischemia
Liver diseases
THYROID ECTOPIC
Breast Cancer
primary tumor
Adenocarcinoma
THYROID CARCINOMA MEDULLARY
Multicystic Dysplastic Kidney
Cancer
GOITER COLLOID
Colorectal Carcinoma
Lymphoma
Carcinoma Non-Small Cell Lung
Pathological Processes
COLON ADENOCARCINOMA
Encephalitis Venezuelan Equine
Colorectal Cancer
HNSCC
Inflammation
Smooth Muscle Tumor
Thyroid Neoplasms
Hypertrophy
prostate cancer
Tumors
Metastasis
prostatic adenocarcinoma
Carcinoma Ductal
Glioblastoma
virus infection
neoplastic transformation
BREAST CARCINOMA
Melanoma
Colon Cancer
Adenoma Follicular
Glioma
Hyperplasia
PITUITARY ADENOMA
ARPKD
Goiter Nodular
Squamous Cell Cancer
Oligodendroglioma
Cholesteatoma
Astrocytoma
Carcinoma
stage breast cancer
Thyroid Cancer
PROSTATE CARCINOMA
epithelial tumor
GASTROINTESTINAL TUMOR
Chordoma
metastatic cancer
Carcinoma Papillary
Laryngeal Cancer
metastatic melanoma
Carcinoma Anaplastic
THYROID PAPILLARY CARCINOMA
Pancreatic Cancer
Goiter
aggressive behavior
THYROID ADENOMA
Carcinoma Mucinous
gestational trophoblastic disease
Pancreatic tumor
Adenoma
Carcinoma Adenoid Cystic
Prostatic Intraepithelial Neoplasia
benign tumor
Carcinoma Medullary
Cholangiocarcinoma
Thyroid Diseases
Carcinoma Squamous Cell
papillary thyroid cancer
Graves Disease
Hashimotos Thyroiditis
THYROID CARCINOMA
Pilocytic Astrocytoma

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LGALS3 Gene

lectin, galactoside-binding, soluble, 3

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