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Aliases for LGALS3 Gene

Aliases for LGALS3 Gene

  • Lectin, Galactoside-Binding, Soluble, 3 2 3
  • Carbohydrate-Binding Protein 35 3 4
  • Galactose-Specific Lectin 3 3 4
  • Laminin-Binding Protein 3 4
  • IgE-Binding Protein 3 4
  • 35 KDa Lectin 3 4
  • Lectin L-29 3 4
  • GALBP 3 4
  • MAC2 3 4
  • Galactoside-Binding Protein 4
  • MAC-2 Antigen 3
  • Mac-2 Antigen 4
  • Galectin 3 2
  • LGALS2 3
  • CBP 35 4
  • CBP35 3
  • GALIG 3
  • Gal-3 4
  • GAL3 3
  • L-31 4
  • L31 3

External Ids for LGALS3 Gene

Previous HGNC Symbols for LGALS3 Gene

  • LGALS2

Previous GeneCards Identifiers for LGALS3 Gene

  • GC14P052920
  • GC14P049392
  • GC14P053586
  • GC14P054674
  • GC14P054665
  • GC14P055595
  • GC14P035758

Summaries for LGALS3 Gene

Entrez Gene Summary for LGALS3 Gene

  • This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

GeneCards Summary for LGALS3 Gene

LGALS3 (Lectin, Galactoside-Binding, Soluble, 3) is a Protein Coding gene. Diseases associated with LGALS3 include follicular adenoma and neonatal candidiasis. Among its related pathways are Immune System and Spinal Cord Injury. GO annotations related to this gene include poly(A) RNA binding and chemoattractant activity. An important paralog of this gene is LGALS9B.

UniProtKB/Swiss-Prot for LGALS3 Gene

  • Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Gene Wiki entry for LGALS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS3 Gene

Genomics for LGALS3 Gene

Regulatory Elements for LGALS3 Gene

Transcription factor binding sites by QIAGEN in the LGALS3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LGALS3 Gene

Chromosome:
14
Start:
55,124,110 bp from pter
End:
55,145,430 bp from pter
Size:
21,321 bases
Orientation:
Plus strand

Genomic View for LGALS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGALS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS3 Gene

Proteins for LGALS3 Gene

  • Protein details for LGALS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17931-LEG3_HUMAN
    Recommended name:
    Galectin-3
    Protein Accession:
    P17931
    Secondary Accessions:
    • B2RC38
    • Q16005
    • Q6IBA7
    • Q96J47

    Protein attributes for LGALS3 Gene

    Size:
    250 amino acids
    Molecular mass:
    26152 Da
    Quaternary structure:
    • Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.

    Three dimensional structures from OCA and Proteopedia for LGALS3 Gene

neXtProt entry for LGALS3 Gene

Proteomics data for LGALS3 Gene at MOPED

Post-translational modifications for LGALS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LGALS3 (Galectin-3)

No data available for DME Specific Peptides for LGALS3 Gene

Domains & Families for LGALS3 Gene

Gene Families for LGALS3 Gene

Protein Domains for LGALS3 Gene

Graphical View of Domain Structure for InterPro Entry

P17931

UniProtKB/Swiss-Prot:

LEG3_HUMAN :
  • Contains 1 galectin domain.
Domain:
  • Contains 1 galectin domain.
genes like me logo Genes that share domains with LGALS3: view

Function for LGALS3 Gene

Molecular function for LGALS3 Gene

GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 3 (L31),pre mRNA splicing factor
UniProtKB/Swiss-Prot Function:
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Gene Ontology (GO) - Molecular Function for LGALS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2402511
GO:0019863 IgE binding IDA 2261464
GO:0030246 carbohydrate binding IEA --
GO:0042056 chemoattractant activity IDA 10925302
GO:0043236 laminin binding IDA 2402511
genes like me logo Genes that share ontologies with LGALS3: view
genes like me logo Genes that share phenotypes with LGALS3: view

Animal Models for LGALS3 Gene

MGI Knock Outs for LGALS3:

Animal Model Products

miRNA for LGALS3 Gene

miRTarBase miRNAs that target LGALS3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGALS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LGALS3 Gene

Localization for LGALS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS3 Gene

Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS3 Gene COMPARTMENTS Subcellular localization image for LGALS3 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 4
cytoskeleton 2
cytosol 2
vacuole 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LGALS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 19706535
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 7682704
GO:0005681 spliceosomal complex IEA --
genes like me logo Genes that share ontologies with LGALS3: view

Pathways & Interactions for LGALS3 Gene

genes like me logo Genes that share pathways with LGALS3: view

Pathways by source for LGALS3 Gene

1 Cell Signaling Technology pathway for LGALS3 Gene
1 GeneGo (Thomson Reuters) pathway for LGALS3 Gene

PCR Array Products

SIGNOR curated interactions for LGALS3 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for LGALS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0002548 monocyte chemotaxis IDA 10925302
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with LGALS3: view

Drugs & Compounds for LGALS3 Gene

(25) Drugs for LGALS3 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 971
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1127
Heparin Approved, Investigational Pharma Antagonist 672,226
Nitric Oxide Approved Pharma 540

(37) Additional Compounds for LGALS3 Gene - From: NovoSeek

genes like me logo Genes that share compounds with LGALS3: view

Transcripts for LGALS3 Gene

Unigene Clusters for LGALS3 Gene

Lectin, galactoside-binding, soluble, 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGALS3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for LGALS3 Gene

GeneLoc Exon Structure for
LGALS3
ECgene alternative splicing isoforms for
LGALS3

Expression for LGALS3 Gene

mRNA expression in normal human tissues for LGALS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS3 Gene

This gene is overexpressed in Colon - Transverse (x5.3).

Protein differential expression in normal tissues from HIPED for LGALS3 Gene

This gene is overexpressed in Nasal epithelium (7.1) and Hair follicle (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LGALS3 Gene



SOURCE GeneReport for Unigene cluster for LGALS3 Gene Hs.531081

mRNA Expression by UniProt/SwissProt for LGALS3 Gene

P17931-LEG3_HUMAN
Tissue specificity: A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
genes like me logo Genes that share expression patterns with LGALS3: view

Protein tissue co-expression partners for LGALS3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LGALS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LGALS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LGALS3 35
  • 84.01 (n)
  • 81.71 (a)
LGALS3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LGALS3 35
  • 85.73 (n)
  • 86 (a)
LGALS3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgals3 35
  • 83.2 (n)
  • 85.66 (a)
Lgals3 16
Lgals3 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGALS3 35
  • 99.07 (n)
  • 98 (a)
LGALS3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgals3 35
  • 81.93 (n)
  • 83.53 (a)
oppossum
(Monodelphis domestica)
Mammalia LGALS3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGALS3 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LGALS3 35
  • 65.07 (n)
  • 66.09 (a)
LGALS3 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LGALS3 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals3 35
  • 56.9 (n)
  • 52.3 (a)
MGC75803 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52947 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-67f24.5 35
  • 55.46 (n)
  • 50.22 (a)
LGALS3 36
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11374 36
  • 9 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lec-12 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
CSA.123 36
  • 19 (a)
ManyToMany
Species with no ortholog for LGALS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LGALS3 Gene

ENSEMBL:
Gene Tree for LGALS3 (if available)
TreeFam:
Gene Tree for LGALS3 (if available)

Paralogs for LGALS3 Gene

genes like me logo Genes that share paralogs with LGALS3: view

Variants for LGALS3 Gene

Sequence variations from dbSNP and Humsavar for LGALS3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4644 - 55,138,217(+) CTACC(A/C)TGGAG missense, reference, nc-transcript-variant
rs4652 - 55,138,318(+) GTGCC(A/C)CCGGA reference, missense, nc-transcript-variant
rs11001 -- 55,145,176(+) TGTTG(C/T)AGTAC intron-variant, reference, stop-gained, nc-transcript-variant
rs11125 -- 55,145,121(+) ATACA(A/T)GTACT intron-variant, reference, missense, nc-transcript-variant
rs1009977 -- 55,136,284(+) CCAAA(G/T)ATTTT intron-variant, upstream-variant-2KB

Variation tolerance for LGALS3 Gene

Residual Variation Intolerance Score: 69.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS3 Gene

HapMap Linkage Disequilibrium report
LGALS3
Human Gene Mutation Database (HGMD)
LGALS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LGALS3 Gene

Disorders for LGALS3 Gene

MalaCards: The human disease database

(26) MalaCards diseases for LGALS3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
follicular adenoma
  • thyroid follicular adenoma
neonatal candidiasis
  • neonatal candida infection
nodular goiter
  • goiter, nodular
malignant struma ovarii
  • struma ovarii, malignant
multicystic dysplastic kidney
  • mcdk
- elite association

Relevant External Links for LGALS3

Genetic Association Database (GAD)
LGALS3
Human Genome Epidemiology (HuGE) Navigator
LGALS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS3
genes like me logo Genes that share disorders with LGALS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS3 Gene

Publications for LGALS3 Gene

  1. Serum levels of galectin-3 and its ligand 90k/mac-2bp in colorectal cancer patients. (PMID: 19686089) Iacovazzi P.A. … Altomare D.F. (Immunopharmacol Immunotoxicol 2010) 23 67
  2. Galectin-3 is associated with prostasomes in human semen. (PMID: 19830550) Jones J.L. … Diekman A.B. (Glycoconj. J. 2010) 23 67
  3. Galectin-3, a marker for vacuole lysis by invasive pathogens. (PMID: 19951367) Paz I. … Sansonetti P. (Cell. Microbiol. 2010) 23 67
  4. Expression of Galectin-3 in renal neoplasms: a diagnostic, possible prognostic marker. (PMID: 20073610) Dancer J.Y. … Shen S.S. (Arch. Pathol. Lab. Med. 2010) 23 67
  5. CD133(+) human pulmonary adenocarcinoma cells induce apoptosis of CD8(+) T cells by highly expressed galectin-3. (PMID: 20144269) Li W. … Feng Z. (Clin Invest Med 2010) 23 67

Products for LGALS3 Gene

Sources for LGALS3 Gene

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