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LGALS2 Gene

protein-coding   GIFtS: 59
GCID: GC22M037966

Lectin, Galactoside-Binding, Soluble, 2

  See LGALS2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lectin, Galactoside-Binding, Soluble, 21 2     S-Lac Lectin 22 3
Galectin 21 2     gal-22
Beta-Galactoside-Binding Lectin L-14-II2 3     galectin-22
Lactose-Binding Lectin 22 3     Gal-23
HL142 3     

External Ids:    HGNC: 65621   Entrez Gene: 39572   Ensembl: ENSG000001000797   OMIM: 1505715   UniProtKB: P051623   

Export aliases for LGALS2 gene to outside databases

Previous GC identifers: GC22M034580 GC22M036209 GC22M036290 GC22M020933


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LGALS2 Gene:
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a
homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter
the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. (provided by
RefSeq, Jul 2008)

GeneCards Summary for LGALS2 Gene:
LGALS2 (lectin, galactoside-binding, soluble, 2) is a protein-coding gene. Diseases associated with LGALS2 include myocardial infarction, and coronary artery disease. GO annotations related to this gene include galactoside binding and carbohydrate binding. An important paralog of this gene is LGALS1.

UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162
Function: This protein binds beta-galactoside. Its physiological function is not yet known

Gene Wiki entry for LGALS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LGALS2 gene promoter:
         AP-1   ATF-2   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGALS2 promoter sequence
   Search Chromatin IP Primers for LGALS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LGALS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

LGALS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037966:  view genomic region     (about GC identifiers)

Start:
37,966,253 bp from pter      End:
37,978,623 bp from pter
Size:
12,371 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162 (See protein sequence)
Recommended Name: Galectin-2  
Size: 132 amino acids; 14644 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for LGALS2:
1HLC (3D)    
Secondary accessions: Q6FGY4

Explore the universe of human proteins at neXtProt for LGALS2: NX_P05162

Explore proteomics data for LGALS2 at MOPED


See LGALS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006489.1  
ENSEMBL proteins: 
 ENSP00000215886   ENSP00000407351  

LGALS2 Human Recombinant Protein Products:

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R&D Systems Recombinant & Natural Proteins for LGALS2 (Galectin-2)
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Novus Biologicals LGALS2 Proteins
Novus Biologicals LGALS2 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for LGALS2
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for LGALS2 

LGALS2 Antibody Products:

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Search for Antibodies for LGALS2 at Abcam
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ThermoFisher Antibodies for LGALS2
LSBio Antibodies in human, mouse, rat for LGALS2

LGALS2 Assay Products:

Browse Kits and Assays available from EMD Millipore
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Browse Enzo Life Sciences for kits & assays
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Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for LGALS2 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LGALS: Lectins, galactoside-binding

3 InterPro protein domains:
 IPR001079 Galectin_CRD
 IPR013320 ConA-like_subgrp
 IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry P05162

ProtoNet protein and cluster: P05162

1 Blocks protein domain: IPB001079 Galectin

UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162
Similarity: Contains 1 galectin domain


Find genes that share domains with LGALS2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LEG2_HUMAN, P05162
Function: This protein binds beta-galactoside. Its physiological function is not yet known

     Genatlas biochemistry entry for LGALS2:
lectin,galactoside-beta binding,soluble 2 (L14-II)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016936galactoside binding IEA--
GO:0030246carbohydrate binding IEA--
     
Find genes that share ontologies with LGALS2           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for LGALS2:
 Decreased influenza A/WSN/33 r 

     1 MGI phenotypic allele for Lgals2 (no phenotypes)

Find genes that share phenotypes with LGALS2           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Lgals2tm1.1Cfg for LGALS2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LGALS2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LGALS2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LGALS2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGALS2

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat LGALS2

Gene Editing
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DNA2.0 Custom Protein Engineering Service for LGALS2

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OriGene clones in human, mouse for LGALS2 (see all 6)
OriGene ORF clones in mouse, rat for LGALS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LGALS2 (NM_006498)
Sino Biological Human cDNA Clone for LGALS2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
mitochondrion2
nucleus2
extracellular1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LGALS2
Interactions:

    GeneGlobe Interaction Network for LGALS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for LGALS2 (P051622, 3 ENSP000002158864) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
ENSG00000231408P013742, 3, ENSP000004165094MINT-49838 MINT-49837 MINT-49836 I2D: score=4 STRING: ENSP00000416509
LTAP013742, 3, ENSP000004034954MINT-49838 MINT-49837 MINT-49836 I2D: score=4 STRING: ENSP00000403495
ENSG00000230279P013742, 3MINT-49838 MINT-49837 MINT-49836 I2D: score=4 
TUBA1AQ71U362, 3, ENSP000003010714MINT-49843 I2D: score=1 STRING: ENSP00000301071
TUBA4AP683663, ENSP000002484374I2D: score=2 STRING: ENSP00000248437
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LGALS2 (LEG2)

1 DrugBank Compound for LGALS2    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Beta-D-Glucose-- 50-99-7target--10592235



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for LGALS2 gene: 
NM_006498.2  

Unigene Cluster for LGALS2:

Lectin, galactoside-binding, soluble, 2
Hs.531776  [show with all ESTs]
Unigene Representative Sequence: AK130682
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000215886(uc003ata.3) ENST00000416480
miRNA
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Search for qRT-PCR Assays for microRNAs that regulate LGALS2
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for LGALS2
Predesigned siRNA for gene silencing in human, mouse, rat LGALS2
Clone
Products:
     
OriGene clones in human, mouse for LGALS2 (see all 6)
OriGene ORF clones in mouse, rat for LGALS2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LGALS2 (NM_006498)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for LGALS2
OriGene qSTAR qPCR primer pairs in human, mouse for LGALS2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LGALS2
  QuantiTect SYBR Green Assays in human, mouse, rat LGALS2
  QuantiFast Probe-based Assays in human, mouse, rat LGALS2

Additional mRNA sequence: 

AK130682.1 BC029063.2 BC059782.1 CR456512.1 CR541972.1 CR542000.1 M14079.1 M87842.1 

5 DOTS entries:

DT.210626  DT.100019106  DT.101963620  DT.120629198  DT.120629201 

Selected AceView cDNA sequences (see all 39):

BU584354 AI275539 BI833192 CR542000 AI288931 BX108632 NM_006498 CR456512 
CA449528 H55575 CR541972 BC029063 M87842 BC059782 AW949542 AA872397 
T28672 BG190992 AA927697 M14079 AI299922 AA917836 AU185862 AI378809 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LGALS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCCTCTTTCA
LGALS2 Expression
About this image


LGALS2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Pancreas (Endocrine System)
         Islets of Langerhans
 
 NULL (Uncategorized)
         Vascular endothelial growth factor-induced embryoid bodies
 
 Ovary (Reproductive System)
         Granulosa Cells Primary Follicle
 
 Blood (Hematopoietic System)
         Monocytes Peripheral Blood
 
 Colon (Gastrointestinal Tract)
LGALS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LGALS2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.531776
    Custom PCR Arrays for LGALS2
Primer
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OriGene qPCR primer pairs and template standards for LGALS2
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QuantiFast Probe-based Assays in human, mouse, rat LGALS2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for LGALS2 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lgals21 , 5 lectin, galactose-binding, soluble 21, 5 74.62(n)1
66.15(a)1
  15 (37.70 cM)5
1077531  NM_025622.31  NP_079898.21 
 788508625 
chicken
(Gallus gallus)
Aves LGALS21 lectin, galactoside-binding, soluble, 2 61.83(n)
54.2(a)
  425107  XM_001234399.3  XP_001234400.2 
tropical clawed frog
(Xenopus tropicalis)
Amphibia lgals21 lectin, galactoside-binding, soluble, 2 57.76(n)
48.85(a)
  100144680  NM_001123441.1  NP_001116913.1 


ENSEMBL Gene Tree for LGALS2 (if available)
TreeFam Gene Tree for LGALS2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LGALS2 gene
LGALS12  
10 SIMAP similar genes for LGALS2 using alignment to 3 protein entries:     LEG2_HUMAN (see all proteins):
LGALS1    LGALS3    LGALS4    LGALS7    LGALS7B    LGALS9
LGALS8    LGALS9B    LGALS9C    GRIP1

Find genes that share paralogs with LGALS2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LGALS2 (see all 408)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0365704
A breast cancer sample4--see VAR_0365702 E Q mis40--------
rs119126161,2
C,F,H--20936065(+) gcgggT/Cgcctg 1 -- int11Minor allele frequency- C:0.00WA 2
rs591330861,2
C,F--20936085(+) CTACTC/TGGGAG 1 -- int11Minor allele frequency- T:0.00WA 2
rs614304721,2
C,F--20936109(+) AATTGT/CTTGAA 1 -- int12Minor allele frequency- C:0.33WA CSA 3
rs1429824651,2
C--21882556(+) AGAAAC/TGCCCT 1 -- ds50010--------
rs22353381,2
C,F,A,H--21882581(+) AGACCG/AGTTAA 1 -- ds500128Minor allele frequency- A:0.44EA NS NA WA CSA 4214
rs1475433441,2
C--21882630(+) CTGTCA/CCTACA 1 -- ds50010--------
rs734181871,2
C,F--21882678(+) CACTAC/TGGGAC 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs1926890761,2
--21882706(+) CAGGAC/GATTCT 1 -- ds50010--------
rs1496251441,2
C--21882750(+) GACCAA/GGGGTA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for LGALS2 (37966253 - 37978623 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for LGALS2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv829203CNV Loss20364138
nsv834191CNV Loss17160897
nsv915030CNV Loss21882294
nsv915028CNV Loss21882294

Human Gene Mutation Database (HGMD): LGALS2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LGALS2
DNA2.0 Custom Variant and Variant Library Synthesis for LGALS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 150571   
OMIM disorders: 608446  
2 diseases for LGALS2:    
About MalaCards
myocardial infarction    coronary artery disease

1 disease from the University of Copenhagen DISEASES database for LGALS2:
Myocardial infarction

Find genes that share disorders with LGALS2           About GenesLikeMe

3 Novoseek inferred disease relationships for LGALS2 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
myocardial infarction 58.8 22 17517687 (2), 17493152 (2), 19330599 (1), 19013708 (1) (see all 12)
inflammation 34.5 5 18777589 (1), 16770523 (1), 15129282 (1)
coronary artery disease 24 3 19726041 (3)

Genetic Association Database (GAD): LGALS2
Human Genome Epidemiology (HuGE) Navigator: LGALS2 (24 documents)

Export disorders for LGALS2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LGALS2 gene, integrated from 10 sources (see all 63):
(articles sorted by number of sources associating them with LGALS2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genomic sequence and organization of two members of a human lectin gene family. (PubMed id 1988031)1, 2, 3 Gitt M.A. and Barondes S.H. (Biochemistry 1991)
  2. Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations. (PubMed id 17493152)1, 4, 9 Kimura A....Park J.E. (Tissue Antigens 2007)
  3. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. (PubMed id 15129282)1, 4, 9 Ozaki K....Tanaka T. (Nature 2004)
  4. Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. (PubMed id 15356130)1, 3, 9 Sturm A....Gabius H.J. (J. Immunol. 2004)
  5. Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations. (PubMed id 17497114)1, 4, 9 Sedlacek K....Hengstenberg C. (J. Mol. Med. 2007)
  6. Lack of association between lymphotoxin-alpha, galectin-2 polymorphisms and coronary artery disease: a meta-analysis. (PubMed id 19726041)1, 4, 9 Li W....Hui R. (Atherosclerosis 2010)
  7. Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease. (PubMed id 17040205)1, 4, 9 Asselbergs F.W....Rimm E.B. (Clin. Sci. 2007)
  8. LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians. (PubMed id 17098239)1, 4, 9 Mangino M....Samani N.J. (Atherosclerosis 2007)
  9. Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis. (PubMed id 19330599)1, 4, 9 Panoulas V.F....Kitas G.D. (Clin. Exp. Hypertens. 2009)
  10. Lymphotoxin 252A&gt;G polymorphism is common and associates with myocardial infarction in patients with rheumatoid arthritis. (PubMed id 18230628)1, 4, 9 Panoulas V.F....Kitas G.D. (Ann. Rheum. Dis. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3957 HGNC: 6562 AceView: LGALS2 Ensembl:ENSG00000100079 euGenes: HUgn3957
ECgene: LGALS2 H-InvDB: LGALS2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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PharmGKB entry for LGALS2 Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_280

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LGALS2 gene:
Search GeneIP for patents involving LGALS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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 Block miRNA regulation of human, mouse, rat LGALS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LGALS2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LGALS2 Predesigned siRNA for gene silencing in human, mouse, rat LGALS2
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 Browse ESI BIO Cell Lines and PureStem Progenitors for LGALS2
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LGALS2
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 Browse compounds at ApexBio
 Search Addgene for plasmids for LGALS2
  Search eBioscience for proteins for LGALS2
  Search eBioscience for elisas for LGALS2
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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