LGALS2 Gene
protein-coding GIFtS : 57
GCID: GC22 M037966
lectin, galactoside-binding, soluble, 2
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Aliasesfor LGALS2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Lectin, Galactoside-Binding, Soluble, 2 1 2 Gal-23 HL141 2 3 Galectin 22 Beta-Galactoside-Binding Lectin L-14-II2 3 Galectin-21 Lactose-Binding Lectin 22 3 Gal-23 S-Lac Lectin 22 3
Export aliases for LGALS2 gene to outside databases Previous GC identifers: GC22M034580 GC22M036209 GC22M036290 GC22M020933
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Summariesfor LGALS2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for LGALS2 : The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162 Function : This protein binds beta-galactoside. Its physiological function is not yet knownGene Wiki entry for LGALS2
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Genomic Viewsfor LGALS2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000022.10 NC_018933.1 NT_011520.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the LGALS2 gene promoter: AP-1 ATF-2 c-Jun ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for LGALS2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGALS2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1 LGALS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22M037966: view genomic region
(about GC identifiers )
Start:
37,966,253 bp from pter
End:
37,978,623 bp from pter
Size:
12,371 bases
Orientation:
minus strand
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Proteinsfor LGALS2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162 (See
protein sequence )Recommended Name: Galectin-2 Size : 132 amino acids; 14644 Da
Subunit : Homodimer
1 PDB 3D structure from and Proteopedia for LGALS2 :1HLC (3D)
 
Secondary accessions : Q6FGY4Explore the universe of human proteins at neXtProt for LGALS2: NX_P05162 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P05162 LGALS2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_006489.1 ENSEMBL proteins: ENSP00000215886 ENSP00000407351 Human Recombinant Protein Products: LGALS2 Antibody Products: Assay Products for LGALS2:
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Protein
Domains / Familiesfor LGALS2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
LGALS2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P05162 ProtoNet protein and cluster: P05162
1 Blocks protein family : IPB001079 Galectin UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162 Similarity : Contains 1 galectin domain
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Functionfor LGALS2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162 Function : This protein binds beta-galactoside. Its physiological function is not yet known
Genatlas biochemistry entry for LGALS2 : lectin,galactoside-beta binding,soluble 2 (L14-II) Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for LGALS2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for LGALS2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: LGALS2 (NM_006498 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LGALS2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat LGALS2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016936 galactoside binding
IEA -- GO:0030246 carbohydrate binding
IEA --
LGALS2 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for LGALS2 :Animal Models: Mouse knock-out Lgals2 tm1.1Cfg for LGALS2 1 MGI phenotypic allele for Lgals2 (no phenotypes)
LGALS2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor LGALS2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LGALS2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/10 Interacting proteins for LGALS2 (P05162 2 , 3 ENSP00000215886 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 10 )About this table
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Drugs & Compoundsfor LGALS2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for LGALS2 1 DrugBank Compound for LGALS2 About this table Search CenterWatch for drugs/clinical trials and news about LGALS2 / LEG2
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Transcriptsfor LGALS2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for LGALS2 gene: NM_006498.2 Unigene Cluster for LGALS2:
Lectin, galactoside-binding, soluble, 2 Hs.531776 [show with all ESTs ] Unigene Representative Sequence: AK130682 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000215886 (uc003ata.3 ) ENST00000416480 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for LGALS2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for LGALS2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: LGALS2 (NM_006498 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LGALS2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat LGALS2
Additional cDNA sequence: AK130682.1 BC029063.2 BC059782.1 CR456512.1 CR541972.1 CR542000.1 M14079.1 M87842.1
5 DOTS entries : DT.210626 DT.100019106
DT.101963620 DT.120629198 DT.120629201 24/39 AceView cDNA sequences (see all 39 ):
CR456512 BU584354 H55575 AI275539 NM_006498 CR541972 CR542000 BC029063 CA449528 BC059782 BI833192 M87842 AI288931 BX108632 AI299922 T28672 AU185862 AW949542 AA872397 M14079 BG190992 AA927697 AI378809 AA917836 GeneLoc Exon Structure
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Expression for LGALS2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section LGALS2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCCTCTTTCA
About this image LGALS2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Primary Follicle Granulosa Cells Ovary Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See LGALS2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for LGALS2 SOURCE GeneReport for Unigene cluster: Hs.531776 SABiosciences Custom PCR Arrays for LGALS2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for LGALS2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat LGALS2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat LGALS2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat LGALS2
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Orthologsfor LGALS2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for LGALS2 gene from 2/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for LGALS2 (if available)TreeFam Gene Tree for LGALS2 (if available)
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Paralogsfor LGALS2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for LGALS2 gene LGALS1 2 10 SIMAP similar genes for LGALS2 using alignment to 3 protein entries: LEG2_HUMAN (see all proteins ):LGALS1 LGALS3 LGALS4 LGALS7 LGALS7B LGALS9 LGALS8 LGALS9B LGALS9C GRIP1
LGALS2 for paralogs About GeneDecksing
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Genomic Variantsfor LGALS2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 22 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for LGALS2 (37966253 - 37978623 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for LGALS2: -- Human Gene Mutation Database (HGMD) : LGALS2 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing LGALS2
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Disorders
/ Diseasesfor LGALS2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
LGALS2 for disorders About GeneDecksing
OMIM gene information: 150571
OMIM disorders : --17 diseases for LGALS2 : About MalaCards myocardial infarction myocardial infarction susceptibility smooth muscle tumor pilocytic astrocytoma coronary heart disease inflammatory bowel disease anaplastic astrocytoma squamous cell carcinoma cerebral infarction astrocytoma ptosis rheumatoid arthritis cerebritis arthritis glioblastoma carcinoma malaria 1 disease from the University of Copenhagen DISEASES database for LGALS2 :Myocardial infarction 3 Novoseek disease relationships for LGALS2 gene About this table
Genetic Association Database (GAD): LGALS2 Human Genome Epidemiology (HuGE) Navigator: LGALS2 (24 documents) Export disorders for LGALS2 gene to outside databases
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Publicationsfor LGALS2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for LGALS2 gene, integrated from 9 sources (see all 62 ): (articles sorted by number of sources associating them with LGALS2) Utopia : connect your pdf to the dynamic world of online information
Genomic sequence and organization of two members of a human lectin gene family. (PubMed id 1988031) 1 , 2 , 3 Gitt M.A. and Barondes S.H. (1991) Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. (PubMed id 15129282) 1 , 4, 9 Ozaki K....Tanaka T. (2004) Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. (PubMed id 15356130) 1 , 3, 9 Sturm A....Gabius H.J. (2004) Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses. (PubMed id 15990958) 1 , 4, 9 Ozaki K. and Tanaka T. (2005) Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. (PubMed id 1375225) 1 , 2 , 9 Gitt M.A.... Barondes S.H. (1992) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802) 1 , 2 Collins J.E.... Dunham I. (2004) The DNA sequence of human chromosome 22. (PubMed id 10591208) 1 , 2 Dunham I....O'Brien K.P. (1999) X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution. (PubMed id 8262940) 1 , 2 Lobsanov Y.D.... Rini J.M. (1993) Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. (PubMed id 3020551) 1 , 2 Gitt M.A. and Barondes S.H. (1986)
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External Searches for LGALS2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing LGALS2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing LGALS2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing LGALS2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for LGALS2 Pharmacogenomics, SNPs, Pathways Functional Glycomics Gateway - Glycan Binding http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_280
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About This Section Patent Information for LGALS2 gene: Search GeneIP for patents involving LGALS2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor LGALS2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for LGALS2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for LGALS2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for LGALS2 OriGene Protein Over-expression Lysate for LGALS2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for LGALS2 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for LGALS2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for LGALS2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for LGALS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for LGALS2 OriGene Custom Protein Services for LGALS2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LGALS2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing LGALS2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGALS2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat LGALS2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat LGALS2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat LGALS2
Search Tocris compounds for LGALS2
Recombinant Protein for LGALS2
Search ThermoFisher Antibodies for LGALS2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat LGALS2
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Aliases for LGALS2
Databases for LGALS2
Disorders / Diseases for LGALS2
Domains / Families for LGALS2
Drugs / Compounds for LGALS2
Expression for LGALS2
Function for LGALS2
Genomic Views for LGALS2
Intellectual Property for LGALS2
Orthologs for LGALS2
Paralogs for LGALS2
Pathways / Interactions for LGALS2
Products for LGALS2
Proteins for LGALS2
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Summaries for LGALS2
Transcripts for LGALS2
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