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Aliases for LGALS2 Gene

Aliases for LGALS2 Gene

  • Lectin, Galactoside Binding Soluble 2 2 3
  • Lectin, Galactoside-Binding, Soluble, 2 2 3 5
  • Beta-Galactoside-Binding Lectin L-14-II 3 4
  • Lactose-Binding Lectin 2 3 4
  • S-Lac Lectin 2 3 4
  • Galectin 2 2 3
  • Gal-2 3 4
  • HL14 3 4

External Ids for LGALS2 Gene

Previous GeneCards Identifiers for LGALS2 Gene

  • GC22M034580
  • GC22M036209
  • GC22M036290
  • GC22M037966
  • GC22M020933

Summaries for LGALS2 Gene

Entrez Gene Summary for LGALS2 Gene

  • The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS2 Gene

LGALS2 (Lectin, Galactoside Binding Soluble 2) is a Protein Coding gene. Diseases associated with LGALS2 include myocardial infarction. GO annotations related to this gene include carbohydrate binding and galactoside binding. An important paralog of this gene is LGALS1.

UniProtKB/Swiss-Prot for LGALS2 Gene

  • This protein binds beta-galactoside. Its physiological function is not yet known.

Gene Wiki entry for LGALS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS2 Gene

Genomics for LGALS2 Gene

Regulatory Elements for LGALS2 Gene

Enhancers for LGALS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LGALS2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LGALS2 gene promoter:

Genomic Location for LGALS2 Gene

Chromosome:
22
Start:
37,570,246 bp from pter
End:
37,582,616 bp from pter
Size:
12,371 bases
Orientation:
Minus strand

Genomic View for LGALS2 Gene

Genes around LGALS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LGALS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LGALS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS2 Gene

Proteins for LGALS2 Gene

  • Protein details for LGALS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05162-LEG2_HUMAN
    Recommended name:
    Galectin-2
    Protein Accession:
    P05162
    Secondary Accessions:
    • Q6FGY4

    Protein attributes for LGALS2 Gene

    Size:
    132 amino acids
    Molecular mass:
    14644 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for LGALS2 Gene

neXtProt entry for LGALS2 Gene

Proteomics data for LGALS2 Gene at MOPED

Post-translational modifications for LGALS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LGALS2 Gene

Domains & Families for LGALS2 Gene

Gene Families for LGALS2 Gene

Protein Domains for LGALS2 Gene

Suggested Antigen Peptide Sequences for LGALS2 Gene

Graphical View of Domain Structure for InterPro Entry

P05162

UniProtKB/Swiss-Prot:

LEG2_HUMAN :
  • Contains 1 galectin domain.
Domain:
  • Contains 1 galectin domain.
genes like me logo Genes that share domains with LGALS2: view

Function for LGALS2 Gene

Molecular function for LGALS2 Gene

GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 2 (L14-II)
UniProtKB/Swiss-Prot Function:
This protein binds beta-galactoside. Its physiological function is not yet known.

Gene Ontology (GO) - Molecular Function for LGALS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016936 galactoside binding IEA --
genes like me logo Genes that share ontologies with LGALS2: view
genes like me logo Genes that share phenotypes with LGALS2: view

Animal Models for LGALS2 Gene

MGI Knock Outs for LGALS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LGALS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LGALS2 Gene

Localization for LGALS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS2 Gene COMPARTMENTS Subcellular localization image for LGALS2 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LGALS2 Gene

Pathways & Interactions for LGALS2 Gene

SuperPathways for LGALS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LGALS2 Gene

Drugs & Compounds for LGALS2 Gene

(1) Drugs for LGALS2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-D-Glucose Experimental Pharma Target 0
genes like me logo Genes that share compounds with LGALS2: view

Transcripts for LGALS2 Gene

mRNA/cDNA for LGALS2 Gene

Unigene Clusters for LGALS2 Gene

Lectin, galactoside-binding, soluble, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS2 Gene

No ASD Table

Relevant External Links for LGALS2 Gene

GeneLoc Exon Structure for
LGALS2
ECgene alternative splicing isoforms for
LGALS2

Expression for LGALS2 Gene

mRNA expression in normal human tissues for LGALS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS2 Gene

This gene is overexpressed in Kidney - Cortex (x16.4), Pancreas (x15.7), Small Intestine - Terminal Ileum (x8.0), and Colon - Transverse (x4.4).

Protein differential expression in normal tissues from HIPED for LGALS2 Gene

This gene is overexpressed in Fetal gut (22.4), Islet of Langerhans (22.3), Pancreas (13.4), and Kidney (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LGALS2 Gene



SOURCE GeneReport for Unigene cluster for LGALS2 Gene Hs.531776

genes like me logo Genes that share expression patterns with LGALS2: view

Protein tissue co-expression partners for LGALS2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LGALS2 Gene

Orthologs for LGALS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LGALS2 35
  • 81.54 (n)
  • 75.38 (a)
LGALS3 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LGALS2 35
  • 84.62 (n)
  • 78.46 (a)
LGALS2 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lgals2 35
  • 74.62 (n)
  • 66.15 (a)
Lgals2 16
Lgals2 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGALS2 35
  • 99.24 (n)
  • 98.48 (a)
LGALS2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgals2 35
  • 74.62 (n)
  • 66.92 (a)
oppossum
(Monodelphis domestica)
Mammalia LGALS2 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGALS2 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves LGALS2 35
  • 61.83 (n)
  • 54.2 (a)
LGALS2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals2 35
  • 57.76 (n)
  • 48.85 (a)
Species with no ortholog for LGALS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LGALS2 Gene

ENSEMBL:
Gene Tree for LGALS2 (if available)
TreeFam:
Gene Tree for LGALS2 (if available)

Paralogs for LGALS2 Gene

Paralogs for LGALS2 Gene

(10) SIMAP similar genes for LGALS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LGALS2: view

Variants for LGALS2 Gene

Sequence variations from dbSNP and Humsavar for LGALS2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036570 A breast cancer sample
rs2235339 - 37,570,307(+) CCTTA(C/T)GCTCA reference, missense
rs2179230 -- 37,581,683(+) TTGCC(A/G)AGGGC upstream-variant-2KB
rs2281097 -- 37,570,053(+) TCCCA(C/T)GTTTT downstream-variant-500B
rs2281100 -- 37,571,425(+) AAGAG(A/G)ATGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LGALS2 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv915028 CNV Loss 21882294
nsv834191 CNV Loss 17160897
nsv915030 CNV Loss 21882294

Variation tolerance for LGALS2 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS2 Gene

HapMap Linkage Disequilibrium report
LGALS2
Human Gene Mutation Database (HGMD)
LGALS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS2 Gene

Disorders for LGALS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LGALS2 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LGALS2

Genetic Association Database (GAD)
LGALS2
Human Genome Epidemiology (HuGE) Navigator
LGALS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS2
genes like me logo Genes that share disorders with LGALS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS2 Gene

Publications for LGALS2 Gene

  1. Genomic sequence and organization of two members of a human lectin gene family. (PMID: 1988031) Gitt M.A. … Barondes S.H. (Biochemistry 1991) 2 3 4 67
  2. Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. (PMID: 15356130) Sturm A. … Gabius H.J. (J. Immunol. 2004) 2 3 23
  3. Lack of association between lymphotoxin-alpha, galectin-2 polymorphisms and coronary artery disease: a meta-analysis. (PMID: 19726041) Li W. … Hui R. (Atherosclerosis 2010) 3 23
  4. Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans. (PMID: 20500087) Randall L.M. … Engwerda C.R. (J. Infect. Dis. 2010) 3 23
  5. Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis. (PMID: 19330599) Panoulas V.F. … Kitas G.D. (Clin. Exp. Hypertens. 2009) 3 23

Products for LGALS2 Gene

Sources for LGALS2 Gene

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