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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LGALS2 Gene

protein-coding   GIFtS: 62
GCID: GC22M037966

Lectin, Galactoside-Binding, Soluble, 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lectin, Galactoside-Binding, Soluble, 21 2     S-Lac Lectin 22 3
Galectin 21 2     gal-22
Beta-Galactoside-Binding Lectin L-14-II2 3     galectin-22
Lactose-Binding Lectin 22 3     Gal-23
HL142 3     

External Ids:    HGNC: 65621   Entrez Gene: 39572   Ensembl: ENSG000001000797   OMIM: 1505715   UniProtKB: P051623   

Export aliases for LGALS2 gene to outside databases

Previous GC identifers: GC22M034580 GC22M036209 GC22M036290 GC22M020933


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LGALS2 Gene:
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a
homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter
the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. (provided by
RefSeq, Jul 2008)

GeneCards Summary for LGALS2 Gene: 
LGALS2 (lectin, galactoside-binding, soluble, 2) is a protein-coding gene. Diseases associated with LGALS2 include myocardial infarction, and smooth muscle tumor. GO annotations related to this gene include galactoside binding and carbohydrate binding. An important paralog of this gene is LGALS1.

UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162
Function: This protein binds beta-galactoside. Its physiological function is not yet known

Gene Wiki entry for LGALS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LGALS2 gene promoter:
         AP-1   ATF-2   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGALS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LGALS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGALS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

LGALS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037966:  view genomic region     (about GC identifiers)

Start:
37,966,253 bp from pter      End:
37,978,623 bp from pter
Size:
12,371 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162 (See protein sequence)
Recommended Name: Galectin-2  
Size: 132 amino acids; 14644 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for LGALS2:
1HLC (3D)    
Secondary accessions: Q6FGY4

Explore the universe of human proteins at neXtProt for LGALS2: NX_P05162

Explore proteomics data for LGALS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05162

  • LGALS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LGALS2 Protein Expression
    REFSEQ proteins: NP_006489.1  
    ENSEMBL proteins: 
     ENSP00000215886   ENSP00000407351  

    Human Recombinant Protein Products for LGALS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LGALS2 (Galectin-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LGALS2
    OriGene Protein Over-expression Lysate for LGALS2
    OriGene MassSpec for LGALS2 
    OriGene Custom Protein Services for LGALS2
    GenScript Custom Purified and Recombinant Proteins Services for LGALS2
    Novus Biologicals LGALS2 Proteins
    Novus Biologicals LGALS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LGALS2
    Browse Proteins at Cloud-Clone Corp. 


    LGALS2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LGALS2 (Galectin-2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LGALS2
    GenScript Custom Superior Antibodies Services for LGALS2
    Novus Biologicals LGALS2 Antibodies
    Abcam antibodies for LGALS2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for LGALS2
    LSBio Antibodies in human, mouse, rat for LGALS2 

    Assay Products for LGALS2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LGALS2
    R&D Systems Proteome Profiler Antibody Arrays for LGALS2 (Galectin-2)
    GenScript Custom Assay Services for LGALS2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LGALS: Lectins, galactoside-binding

    3 InterPro protein domains:
     IPR001079 Galectin_CRD
     IPR013320 ConA-like_subgrp
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P05162

    ProtoNet protein and cluster: P05162

    1 Blocks protein domain: IPB001079 Galectin

    UniProtKB/Swiss-Prot: LEG2_HUMAN, P05162
    Similarity: Contains 1 galectin domain


    LGALS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEG2_HUMAN, P05162
    Function: This protein binds beta-galactoside. Its physiological function is not yet known

         Genatlas biochemistry entry for LGALS2:
    lectin,galactoside-beta binding,soluble 2 (L14-II)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016936galactoside binding IEA--
    GO:0030246carbohydrate binding IEA--
         
    LGALS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LGALS2:
     Decreased influenza A/WSN/33 r 

         1 MGI phenotypic allele for Lgals2 (no phenotypes)

    LGALS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lgals2tm1.1Cfg for LGALS2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LGALS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LGALS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LGALS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGALS2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LGALS2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LGALS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LGALS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LGALS2
    Sirion Biotech Customized adenovirus for overexpression of LGALS2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LGALS2 (see all 6)
    OriGene ORF clones in mouse, rat for LGALS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LGALS2 (NM_006498)
    Sino Biological Human cDNA Clone for LGALS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS2
    Sirion Biotech Customized lentivirus for stable overexpression of LGALS2 
                         Customized lentivirus expression plasmids for stable overexpression of LGALS2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LGALS2
    Search LifeMap BioReagents cell lines for LGALS2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LGALS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/11 Interacting proteins for LGALS2 (P051622, 3 ENSP000002158864) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000231408P013742, 3, ENSP000004165094MINT-49838 MINT-49837 MINT-49836 I2D: score=4 STRING: ENSP00000416509
    LTAP013742, 3, ENSP000004034954MINT-49838 MINT-49837 MINT-49836 I2D: score=4 STRING: ENSP00000403495
    ENSG00000230279P013742, 3MINT-49838 MINT-49837 MINT-49836 I2D: score=4 
    TUBA1AQ71U362, 3, ENSP000003010714MINT-49843 I2D: score=1 STRING: ENSP00000301071
    TUBA4AP683663, ENSP000002484374I2D: score=2 STRING: ENSP00000248437
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LGALS2 (LEG2)

    1 DrugBank Compound for LGALS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Beta-D-Glucose-- 50-99-7target--10592235

    Search CenterWatch for drugs/clinical trials and news about LGALS2 / LEG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LGALS2 gene: 
    NM_006498.2  

    Unigene Cluster for LGALS2:

    Lectin, galactoside-binding, soluble, 2
    Hs.531776  [show with all ESTs]
    Unigene Representative Sequence: AK130682
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215886(uc003ata.3) ENST00000416480
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LGALS2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LGALS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LGALS2
    Clone
    Products:
         
    OriGene clones in human, mouse for LGALS2 (see all 6)
    OriGene ORF clones in mouse, rat for LGALS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LGALS2 (NM_006498)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS2
    Sirion Biotech Customized lentivirus for stable overexpression of LGALS2 
                         Customized lentivirus expression plasmids for stable overexpression of LGALS2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LGALS2
    OriGene qSTAR qPCR primer pairs in human, mouse for LGALS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LGALS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LGALS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS2

    Additional mRNA sequence: 

    AK130682.1 BC029063.2 BC059782.1 CR456512.1 CR541972.1 CR542000.1 M14079.1 M87842.1 

    5 DOTS entries:

    DT.210626  DT.100019106  DT.101963620  DT.120629198  DT.120629201 

    24/39 AceView cDNA sequences (see all 39):

    CR456512 M87842 CR541972 BC059782 BU584354 CR542000 AI288931 BX108632 
    CA449528 BI833192 AI275539 BC029063 NM_006498 H55575 AA917836 AI378809 
    AU185862 AA927697 AA872397 AI299922 AW949542 BG190992 M14079 T28672 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LGALS2 expression in normal human tissues (normalized intensities)      LGALS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCTTTCA
    LGALS2 Expression
    About this image


    LGALS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 5 entries
             small intestine ; glandular cells   
             ileum   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Kidney (Urinary System)
             kidney ; cells in tubules   
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle

    See LGALS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LGALS2

    SOURCE GeneReport for Unigene cluster: Hs.531776
        SABiosciences Custom PCR Arrays for LGALS2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LGALS2
    OriGene qSTAR qPCR primer pairs in human, mouse for LGALS2
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LGALS2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LGALS2 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lgals21 , 5 lectin, galactose-binding, soluble 21, 5 74.62(n)1
    66.15(a)1
      15 (37.70 cM)5
    1077531  NM_025622.31  NP_079898.21 
     788508625 
    chicken
    (Gallus gallus)
    Aves LGALS21 lectin, galactoside-binding, soluble, 2 61.83(n)
    54.2(a)
      425107  XM_001234399.2  XP_001234400.2 


    ENSEMBL Gene Tree for LGALS2 (if available)
    TreeFam Gene Tree for LGALS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LGALS2 gene
    LGALS12  
    10 SIMAP similar genes for LGALS2 using alignment to 3 protein entries:     LEG2_HUMAN (see all proteins):
    LGALS1    LGALS3    LGALS4    LGALS7    LGALS7B    LGALS9
    LGALS8    LGALS9B    LGALS9C    GRIP1

    LGALS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/408 SNPs in LGALS2 are shown (see all 408)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365704
    A breast cancer sample4--see VAR_0365702 E Q mis40--------
    rs119126161,2
    C,F,H--20936065(+) gcgggT/Cgcctg 1 -- int11Minor allele frequency- C:0.00WA 2
    rs591330861,2
    C,F--20936085(+) CTACTC/TGGGAG 1 -- int11Minor allele frequency- T:0.00WA 2
    rs614304721,2
    C,F--20936109(+) AATTGT/CTTGAA 1 -- int12Minor allele frequency- C:0.33WA CSA 3
    rs1429824651,2
    C--21882556(+) AGAAAC/TGCCCT 1 -- ds50010--------
    rs22353381,2
    C,F,A,H--21882581(+) AGACCG/AGTTAA 1 -- ds500128Minor allele frequency- A:0.44EA NS NA WA CSA 4214
    rs1475433441,2
    C--21882630(+) CTGTCA/CCTACA 1 -- ds50010--------
    rs734181871,2
    C,F--21882678(+) CACTAC/TGGGAC 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1926890761,2
    --21882706(+) CAGGAC/GATTCT 1 -- ds50010--------
    rs1496251441,2
    C--21882750(+) GACCAA/GGGGTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LGALS2 (37966253 - 37978623 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LGALS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829203CNV Loss20364138
    nsv834191CNV Loss17160897
    nsv915030CNV Loss21882294
    nsv915028CNV Loss21882294


    Human Gene Mutation Database (HGMD): LGALS2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LGALS2
    DNA2.0 Custom Variant and Variant Library Synthesis for LGALS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 150571    OMIM disorders: --

    16 diseases for LGALS2:    About MalaCards
    myocardial infarction    smooth muscle tumor    pilocytic astrocytoma    cerebral infarction
    anaplastic astrocytoma    astrocytoma    coronary heart disease    malaria
    inflammatory bowel disease    cerebritis    glioblastoma    rheumatoid arthritis
    arthritis    atherosclerosis    squamous cell carcinoma    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for LGALS2:
    Myocardial infarction

    LGALS2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for LGALS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myocardial infarction 58.8 22 17517687 (2), 17493152 (2), 19330599 (1), 19013708 (1) (see all 12)
    inflammation 34.5 5 18777589 (1), 16770523 (1), 15129282 (1)
    coronary artery disease 24 3 19726041 (3)

    Genetic Association Database (GAD): LGALS2
    Human Genome Epidemiology (HuGE) Navigator: LGALS2 (24 documents)

    Export disorders for LGALS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LGALS2 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with LGALS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic sequence and organization of two members of a human lectin gene family. (PubMed id 1988031)1, 2, 3 Gitt M.A. and Barondes S.H. (1991)
    2. Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations. (PubMed id 17493152)1, 4, 9 Kimura A....Park J.E. (2007)
    3. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. (PubMed id 15129282)1, 4, 9 Ozaki K....Tanaka T. (2004)
    4. Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. (PubMed id 15356130)1, 3, 9 Sturm A....Gabius H.J. (2004)
    5. Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations. (PubMed id 17497114)1, 4, 9 Sedlacek K....Hengstenberg C. (2007)
    6. Lack of association between lymphotoxin-alpha, galect in-2 polymorphisms and coronary artery disease: a meta-analysis. (PubMed id 19726041)1, 4, 9 Li W....Hui R. (2010)
    7. Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease. (PubMed id 17040205)1, 4, 9 Asselbergs F.W....Rimm E.B. (2007)
    8. LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians. (PubMed id 17098239)1, 4, 9 Mangino M....Samani N.J. (2007)
    9. Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis. (PubMed id 19330599)1, 4, 9 Panoulas V.F....Kitas G.D. (2009)
    10. The Lymphotoxin 252A>G polymorphism is common and associates with Myocardial Infarction in patients with rheumatoid arthritis. (PubMed id 18230628)1, 4, 9 Panoulas V.F....Kitas G.D. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3957 HGNC: 6562 AceView: LGALS2 Ensembl:ENSG00000100079 euGenes: HUgn3957
    ECgene: LGALS2 H-InvDB: LGALS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LGALS2 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_280

    (Patent information from GeneIP,
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    Patent Information for LGALS2 gene:
    Search GeneIP for patents involving LGALS2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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