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Aliases for LGALS2 Gene

Aliases for LGALS2 Gene

  • Lectin, Galactoside-Binding, Soluble, 2 2 3
  • Beta-Galactoside-Binding Lectin L-14-II 3 4
  • Lactose-Binding Lectin 2 3 4
  • S-Lac Lectin 2 3 4
  • Galectin 2 2 3
  • Gal-2 3 4
  • HL14 3 4
  • Galectin-2 3

External Ids for LGALS2 Gene

Previous GeneCards Identifiers for LGALS2 Gene

  • GC22M034580
  • GC22M036209
  • GC22M036290
  • GC22M037966
  • GC22M020933

Summaries for LGALS2 Gene

Entrez Gene Summary for LGALS2 Gene

  • The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS2 Gene

LGALS2 (Lectin, Galactoside-Binding, Soluble, 2) is a Protein Coding gene. Diseases associated with LGALS2 include myocardial infarction and coronary artery disease. GO annotations related to this gene include carbohydrate binding and galactoside binding. An important paralog of this gene is LGALS1.

UniProtKB/Swiss-Prot for LGALS2 Gene

  • This protein binds beta-galactoside. Its physiological function is not yet known

Gene Wiki entry for LGALS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS2 Gene

Genomics for LGALS2 Gene

Regulatory Elements for LGALS2 Gene

Transcription factor binding sites by QIAGEN in the LGALS2 gene promoter:

Genomic Location for LGALS2 Gene

37,570,246 bp from pter
37,582,616 bp from pter
12,371 bases
Minus strand

Genomic View for LGALS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGALS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS2 Gene

Proteins for LGALS2 Gene

  • Protein details for LGALS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FGY4

    Protein attributes for LGALS2 Gene

    132 amino acids
    Molecular mass:
    14644 Da
    Quaternary structure:
    • Homodimer

    Three dimensional structures from OCA and Proteopedia for LGALS2 Gene

neXtProt entry for LGALS2 Gene

Proteomics data for LGALS2 Gene at MOPED

Post-translational modifications for LGALS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LGALS2 Gene

Domains for LGALS2 Gene

Gene Families for LGALS2 Gene

  • LGALS :Lectins, galactoside-binding

Protein Domains for LGALS2 Gene

Suggested Antigen Peptide Sequences for LGALS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P05162
  • Contains 1 galectin domain.
genes like me logo Genes that share domains with LGALS2: view

Function for LGALS2 Gene

Molecular function for LGALS2 Gene

GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 2 (L14-II)
UniProtKB/Swiss-Prot Function:
This protein binds beta-galactoside. Its physiological function is not yet known

Gene Ontology (GO) - Molecular Function for LGALS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016936 galactoside binding IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LGALS2: view

Phenotypes for LGALS2 Gene

GenomeRNAi human phenotypes for LGALS2:
genes like me logo Genes that share phenotypes with LGALS2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGALS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LGALS2 Gene

Localization for LGALS2 Gene

Subcellular locations from

Jensen Localization Image for LGALS2 Gene COMPARTMENTS Subcellular localization image for LGALS2 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LGALS2 Gene

Pathways for LGALS2 Gene

SuperPathways for LGALS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LGALS2 Gene


No data available for Pathways by source for LGALS2 Gene

Compounds for LGALS2 Gene

(1) Drugbank Compounds for LGALS2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
50-99-7 target
genes like me logo Genes that share compounds with LGALS2: view

Transcripts for LGALS2 Gene

mRNA/cDNA for LGALS2 Gene

Unigene Clusters for LGALS2 Gene

Lectin, galactoside-binding, soluble, 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGALS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS2 Gene

No ASD Table

Relevant External Links for LGALS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LGALS2 Gene

mRNA expression in normal human tissues for LGALS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LGALS2 Gene

This gene is overexpressed in Kidney - Cortex (16.4), Pancreas (15.7), Small Intestine - Terminal Ileum (8.0), and Colon - Transverse (4.4).

Protein differential expression in normal tissues for LGALS2 Gene

This gene is overexpressed in Fetal gut (22.4), Islet of Langerhans (22.3), Pancreas (13.4), and Kidney (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LGALS2 Gene

SOURCE GeneReport for Unigene cluster for LGALS2 Gene Hs.531776

genes like me logo Genes that share expressions with LGALS2: view

Expression partners for LGALS2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LGALS2 Gene

Orthologs for LGALS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LGALS2 35
  • 81.54 (n)
  • 75.38 (a)
  • 78 (a)
(Canis familiaris)
Mammalia LGALS2 35
  • 84.62 (n)
  • 78.46 (a)
  • 76 (a)
(Mus musculus)
Mammalia Lgals2 35
  • 74.62 (n)
  • 66.15 (a)
Lgals2 16
Lgals2 36
  • 65 (a)
(Pan troglodytes)
Mammalia LGALS2 35
  • 99.24 (n)
  • 98.48 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Lgals2 35
  • 74.62 (n)
  • 66.92 (a)
(Monodelphis domestica)
Mammalia LGALS2 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia LGALS2 36
  • 44 (a)
(Gallus gallus)
Aves LGALS2 35
  • 61.83 (n)
  • 54.2 (a)
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lgals2 35
  • 57.76 (n)
  • 48.85 (a)
Species with no ortholog for LGALS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LGALS2 Gene

Gene Tree for LGALS2 (if available)
Gene Tree for LGALS2 (if available)

Paralogs for LGALS2 Gene

Paralogs for LGALS2 Gene

Selected SIMAP similar genes for LGALS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LGALS2: view

Variants for LGALS2 Gene

Sequence variations from dbSNP and Humsavar for LGALS2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs140057 -- 37,573,184(+) gagaa(C/T)ggctt intron-variant
rs140058 -- 37,574,465(+) GAGCC(A/G)AGATT intron-variant
rs140059 -- 37,581,411(+) CTTTA(A/T)TGCCT upstream-variant-2KB
rs968725 -- 37,577,188(+) AAGGT(C/G/T)GGGAG intron-variant
rs1969639 -- 37,580,969(+) cagct(A/G)ctcaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LGALS2 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv915028 CNV Loss 21882294
nsv834191 CNV Loss 17160897
nsv915030 CNV Loss 21882294

Relevant External Links for LGALS2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS2 Gene

Disorders for LGALS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for LGALS2 Gene in MalaCards »

(2) Diseases for LGALS2 Gene including...

(1) OMIM Diseases for LGALS2 Gene (150571)

(1) University of Copenhagen DISEASES for LGALS2 Gene

(3) Novoseek inferred disease relationships for LGALS2 Gene

Disease -log(P) Hits PubMed IDs
myocardial infarction 58.8 14
inflammation 34.5 3
coronary artery disease 24 3

Relevant External Links for LGALS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LGALS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS2 Gene

Publications for LGALS2 Gene

  1. Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. (PMID: 1375225) Gitt M.A. … Barondes S.H. (J. Biol. Chem. 1992) 3 4 23
  2. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. (PMID: 15129282) Ozaki K. … Tanaka T. (Nature 2004) 3 23 48
  3. Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. (PMID: 15356130) Sturm A. … Gabius H.J. (J. Immunol. 2004) 2 3 23
  4. Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses. (PMID: 15990958) Ozaki K. … Tanaka T. (Cell. Mol. Life Sci. 2005) 3 23 48
  5. Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart disease. (PMID: 17040205) Asselbergs F.W. … Rimm E.B. (Clin. Sci. 2007) 3 23 48

Products for LGALS2 Gene

Sources for LGALS2 Gene

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