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LGALS13 Gene

protein-coding   GIFtS: 56
GCID: GC19P040093

Lectin, Galactoside-Binding, Soluble, 13

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lectin, Galactoside-Binding, Soluble, 131 2     Beta-Galactoside-Binding Lectin2
PP132 3 5     gal-132
Galectin 131 2     Galactoside-Binding Soluble Lectin 132
Placental Protein 132 3     galectin-132
Placental Tissue Protein 132 3     Gal-133
PLAC82 3     Galectin-133
GAL132 5     

External Ids:    HGNC: 154491   Entrez Gene: 291242   Ensembl: ENSG000001051987   OMIM: 6087175   UniProtKB: Q9UHV83   

Export aliases for LGALS13 gene to outside databases

Previous GC identifers: GC19P044786 GC19P044787 GC19P036539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LGALS13 Gene:
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids.
The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which
are held together by disulfide bonds. This protein has structural similarity to several members of the
beta-galactoside-binding S-type lectin family. (provided by RefSeq, Jul 2008)

GeneCards Summary for LGALS13 Gene:
LGALS13 (lectin, galactoside-binding, soluble, 13) is a protein-coding gene. Diseases associated with LGALS13 include patau syndrome, and hellp syndrome. GO annotations related to this gene include lysophospholipase activity and carbohydrate binding. An important paralog of this gene is CLC.

UniProtKB/Swiss-Prot: PP13_HUMAN, Q9UHV8
Function: Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis

Gene Wiki entry for LGALS13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the LGALS13 gene promoter:
         NRSF form 1   Bach2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGALS13 promoter sequence
   Search Chromatin IP Primers for LGALS13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LGALS13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

LGALS13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS13 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P040093:  view genomic region     (about GC identifiers)

Start:
40,093,164 bp from pter      End:
40,098,116 bp from pter
Size:
4,953 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PP13_HUMAN, Q9UHV8 (See protein sequence)
Recommended Name: Galactoside-binding soluble lectin 13  
Size: 139 amino acids; 16119 Da
Subunit: Homodimer; disulfide-linked
1 PDB 3D structure from and Proteopedia for LGALS13:
1F87 (3D)    
Secondary accessions: C5HZ15

Explore the universe of human proteins at neXtProt for LGALS13: NX_Q9UHV8

Explore proteomics data for LGALS13 at MOPED


See LGALS13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_037400.1  
ENSEMBL proteins: 
 ENSP00000221797   ENSP00000470928  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LGALS: Lectins, galactoside-binding

3 InterPro protein domains:
 IPR001079 Galectin_CRD
 IPR013320 ConA-like_subgrp
 IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q9UHV8

ProtoNet protein and cluster: Q9UHV8

1 Blocks protein domain: IPB001079 Galectin

UniProtKB/Swiss-Prot: PP13_HUMAN, Q9UHV8
Similarity: Contains 1 galectin domain


LGALS13 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PP13_HUMAN, Q9UHV8
Function: Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004622lysophospholipase activity TAS10527825
GO:0005515protein binding IPI--
GO:0030246carbohydrate binding IEA--
     
LGALS13 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for LGALS13:
 Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LGALS13
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGALS13

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS13

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS13


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol1
mitochondrion1
nucleus1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for LGALS13 About    
See pathways by source

SuperPathContained pathways About
1Integrated Breast Cancer Pathway
Integrated Breast Cancer Pathway


1 BioSystems Pathway for LGALS13
    Integrated Breast Cancer Pathway



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LGALS13
Interactions:

    GeneGlobe Interaction Network for LGALS13

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for LGALS13 (Q9UHV81, 3 ENSP000002217974) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
ANXA2P073553, ENSP000003460324I2D: score=2 STRING: ENSP00000346032
ACTG1P632613, ENSP000003315144I2D: score=2 STRING: ENSP00000331514
CREB5Q029303I2D: score=1 
Hoxa1P090221EBI-3957707,EBI-3957603
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006644phospholipid metabolic process TAS10527825
GO:0006915apoptotic process IEA--

LGALS13 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LGALS13 (PP13)

10 HMDB Compounds for LGALS13    About this table
CompoundSynonyms CAS #PubMed Ids
Arachidic acidArachate (see all 10)506-30-9--
Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
Glycerophosphocholine2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)28319-77-9--
Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
Palmitic acidHexaectylic acid (see all 45)57-10-3--
Pentadecanoic acidPentadecanoate (see all 8)1002-84-2--
Stearic acid1-Heptadecanecarboxylate (see all 12)57-11-4--
Tridecanoic acid(S)-2-Aminotridecanoate (see all 12)638-53-9--

2 Novoseek inferred chemical compound relationships for LGALS13 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
n-acetyllactosamine 71.9 2 11742106 (1), 15009185 (1)
tyrosine 18.1 2 17532461 (1), 18854808 (1)



LGALS13 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for LGALS13 gene: 
NM_013268.2  

Unigene Cluster for LGALS13:

Lectin, galactoside-binding, soluble, 13
Hs.23671  [show with all ESTs]
Unigene Representative Sequence: CB997629
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000221797(uc002omb.3) ENST00000600141 ENST00000600546
miRNA
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Primer
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OriGene qPCR primer pairs and template standards for LGALS13
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Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LGALS13
  QuantiTect SYBR Green Assays in human, mouse, rat LGALS13
  QuantiFast Probe-based Assays in human, mouse, rat LGALS13

Additional mRNA sequence: 

AF117383.1 AY055826.1 BC066304.1 BC069312.1 FJ613336.1 FJ613337.1 FJ613338.1 

3 DOTS entries:

DT.208616  DT.121452870  DT.91721651 

Selected AceView cDNA sequences (see all 28):

BC069312 N41396 BC066304 AI459142 NM_013268 R24614 BF436105 AI800736 
AY055826 CB995660 AI091542 AA706870 BX107774 BF589220 BG015460 AI864108 
AF117383 BQ368735 AI189531 R31311 R31571 R24511 CB995390 CD388102 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for LGALS13    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:                                    
SP2:              -     -               


ECgene alternative splicing isoforms for LGALS13

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LGALS13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGATTCCCAG
LGALS13 Expression
About this image

LGALS13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LGALS13 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.23671

UniProtKB/Swiss-Prot: PP13_HUMAN, Q9UHV8
Tissue specificity: Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta.
Placental expression originates predominantly from the syncytiotrophoblast

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS13

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for LGALS13 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
Uncharacterized protein
38(a)
1 → many
4(383186287-383186752)


ENSEMBL Gene Tree for LGALS13 (if available)
TreeFam Gene Tree for LGALS13 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LGALS13 gene
CLC2  LGALS162  LGALS142  
11 SIMAP similar genes for LGALS13 using alignment to 3 protein entries:     PP13_HUMAN (see all proteins):
LGALS16    LGALS14    LGALS17A    CLC    LOC400696    LGALS9
LGALS9C    LGALS9B    LGALS4    LGALS7    LGALS7B

LGALS13 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LGALS13 (see all 206)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1499707641,2
--40091210(+) AGGAAA/GCTATC 1 -- us2k10--------
rs126102941,2
C,F,H--40091228(+) taaacA/Ggacag 1 -- us2k15Minor allele frequency- G:0.24NA EA 250
rs1894498761,2
--40091263(+) TCAAAC/GTATGT 1 -- us2k10--------
rs118816031,2
C,F,A,H--40091360(+) gtaaaG/CAGCTT 1 -- us2k18Minor allele frequency- C:0.41NA WA EA 368
rs1451916161,2
--40091415(+) AGGCTG/TGTGGA 1 -- us2k10--------
rs1447213251,2
C--40091488(+) AAAAA-/A/AA  
        
TAGCC
1 -- us2k10--------
rs1487277871,2
--40091529(+) GTAGTC/TCCAGC 1 -- us2k10--------
rs1422114431,2
--40091563(+) AAATCA/CCCTGA 1 -- us2k10--------
rs104090991,2
C,F--40091701(+) aaagtA/Gaggat 1 -- us2k12Minor allele frequency- G:0.06NA WA 120
rs1147982181,2
F--40091708(+) GGATAC/TAGGTG 1 -- us2k11Minor allele frequency- T:0.02WA 118

HapMap Linkage Disequilibrium report for LGALS13 (40093164 - 40098116 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for LGALS13:    About this table    
Variant IDTypeSubtypePubMed ID
esv2718554CNV Deletion23290073
nsv2481CNV Insertion18451855
esv34120CNV Loss18971310

Human Gene Mutation Database (HGMD): LGALS13
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LGALS13
DNA2.0 Custom Variant and Variant Library Synthesis for LGALS13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608717    OMIM disorders: --

6 diseases for LGALS13:    
About MalaCards
patau syndrome    hellp syndrome    pre-eclampsia    eclampsia
down syndrome    breast cancer

1 disease from the University of Copenhagen DISEASES database for LGALS13:
pre-eclampsia

LGALS13 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for LGALS13 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
preeclampsia 74.9 15 18791734 (6), 19035985 (2), 19087972 (1), 17618748 (1) (see all 7)

Genetic Association Database (GAD): LGALS13
Human Genome Epidemiology (HuGE) Navigator: LGALS13 (1 document)

Export disorders for LGALS13 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LGALS13 gene, integrated from 10 sources (see all 43):
(articles sorted by number of sources associating them with LGALS13)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein. (PubMed id 10527825)1, 2, 3, 9 Than N.G.... Bohn H. (Placenta 1999)
  2. Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). (PubMed id 6856484)1, 2, 3 Bohn H.... Winckler W. (Oncodev. Biol. Med. 1983)
  3. Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13). (PubMed id 11742106)1, 2, 9 Visegrady B.... Bohn H. (Protein Eng. 2001)
  4. A novel exonic variant (221delT) in the LGALS13 gene encoding placental protein 13 (PP13) is associated with preterm labour in a low risk population. (PubMed id 19818512)1, 4, 9 Gebhardt S....Hillermann R. (J. Reprod. Immunol. 2009)
  5. A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. (PubMed id 19497882)1, 2, 9 Than N.G.... Wildman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies. (PubMed id 15193867)1, 9 Burger O....Gonen R. (Placenta 2004)
  8. Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome. (PubMed id 18791734)1, 9 Than N.G....Papp Z. (Virchows Arch. 2008)
  9. Functional analyses of placental protein 13/galectin-13. (PubMed id 15009185)1, 9 Than N.G....Sumegi B. (Eur. J. Biochem. 2004)
  10. Placental protein 13 as a first trimester screening marker for aneuploidy. (PubMed id 19844942)1, 9 Koster M.P....Schielen P.C. (Prenat. Diagn. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29124 HGNC: 15449 AceView: LGALS13 Ensembl:ENSG00000105198 euGenes: HUgn29124
ECgene: LGALS13 H-InvDB: LGALS13

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for LGALS13 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LGALS13 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LGALS13 gene:
Search GeneIP for patents involving LGALS13

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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