Aliases for LGALS1 Gene
External Ids for LGALS1 Gene
Previous GeneCards Identifiers for LGALS1 Gene
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for LGALS1 Gene
LGALS1 (Galectin 1) is a Protein Coding gene. Diseases associated with LGALS1 include Benign Metastasizing Leiomyoma and Chronic Monocytic Leukemia. Among its related pathways are Validated targets of C-MYC transcriptional repression and Apoptosis and Autophagy. GO annotations related to this gene include poly(A) RNA binding and signal transducer activity. An important paralog of this gene is LGALS2.
UniProtKB/Swiss-Prot for LGALS1 Gene
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.