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LGALS1 Gene

protein-coding   GIFtS: 65
GCID: GC22P038071

Lectin, Galactoside-Binding, Soluble, 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lectin, Galactoside-Binding, Soluble, 11 2     S-Lac Lectin 12 3
Galectin 11 2     GAL12
Beta-Galactoside-Binding Lectin L-14-I2 3     GBP2
Lactose-Binding Lectin 12 3     Beta-Galactoside-Binding Protein 14kDa2
Putative MAPK-Activating Protein PM122 3     gal-12
14 KDa Laminin-Binding Protein2 3     galaptin2
14 KDa Lectin2 3     galectin-12
HBL2 3     Gal-13
HLBP142 3     Galaptin3
HPL2 3     Lectin Galactoside-Binding Soluble 13

External Ids:    HGNC: 65611   Entrez Gene: 39562   Ensembl: ENSG000001000977   OMIM: 1505705   UniProtKB: P093823   

Export aliases for LGALS1 gene to outside databases

Previous GC identifers: GC22P034686 GC22P036314 GC22P036396 GC22P021039


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LGALS1 Gene:
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix
interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for LGALS1 Gene:
LGALS1 (lectin, galactoside-binding, soluble, 1) is a protein-coding gene. Diseases associated with LGALS1 include chondroblastic osteosarcoma, and benign metastasizing leiomyoma. GO annotations related to this gene include protein homodimerization activity and glycoprotein binding. An important paralog of this gene is LGALS2.

UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382
Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide
array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of
Lyn kinase. Strong inducer of T-cell apoptosis

Gene Wiki entry for LGALS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LGALS1 gene promoter:
         p53   AP-1   ATF-2   MyoD   YY1   HEN1   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGALS1 promoter sequence
   Search Chromatin IP Primers for LGALS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LGALS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

LGALS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038071:  view genomic region     (about GC identifiers)

Start:
38,071,613 bp from pter      End:
38,075,813 bp from pter
Size:
4,201 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382 (See protein sequence)
Recommended Name: Galectin-1  
Size: 135 amino acids; 14716 Da
Subunit: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via
poly-N-acetyllactosamine)
Selected PDB 3D structures from and Proteopedia for LGALS1 (see all 13):
1GZW (3D)        1W6M (3D)        1W6N (3D)        1W6O (3D)        1W6P (3D)        1W6Q (3D)    
Secondary accessions: B2R5E8 Q9UDK5

Explore the universe of human proteins at neXtProt for LGALS1: NX_P09382

Explore proteomics data for LGALS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys29, Lys108
  • Modification sites at PhosphoSitePlus

  • See LGALS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002296.1  
    ENSEMBL proteins: 
     ENSP00000215909   ENSP00000404414   ENSP00000388296  

    LGALS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LGALS1 (Galectin-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LGALS1
    OriGene Protein Over-expression Lysate for LGALS1
    OriGene MassSpec for LGALS1
    OriGene Custom Protein Services for LGALS1
    GenScript Custom Purified and Recombinant Proteins Services for LGALS1
    Novus Biologicals LGALS1 Proteins
    Novus Biologicals LGALS1 Lysates
    Sino Biological Recombinant Protein for LGALS1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LGALS1
    Browse Proteins at Cloud-Clone Corp.

    LGALS1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LGALS1
    R&D Systems Antibodies for LGALS1 (Galectin-1)
    Cell Signaling Technology (CST) Antibodies for LGALS1  (galectin-1)
    OriGene Antibodies for LGALS1
    OriGene Custom Antibody Services for LGALS1
    Novus Biologicals LGALS1 Antibodies
    Abcam antibodies for LGALS1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for LGALS1
    LSBio Antibodies in human, mouse, rat for LGALS1

    LGALS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LGALS1
    R&D Systems ELISAs for LGALS1 (Galectin-1)         (see all)
    GenScript Custom Assay Services for LGALS1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    LGALS: Lectins, galactoside-binding

    4 InterPro protein domains:
     IPR001079 Galectin_CRD
     IPR013320 ConA-like_subgrp
     IPR015535 Galectin_1
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P09382

    ProtoNet protein and cluster: P09382

    1 Blocks protein domain: IPB001079 Galectin

    UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382
    Similarity: Contains 1 galectin domain


    LGALS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEG1_HUMAN, P09382
    Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide
    array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of
    Lyn kinase. Strong inducer of T-cell apoptosis

         Genatlas biochemistry entry for LGALS1:
    lectin,galactoside-beta binding,soluble 1,autocrine negative growth factor (L14-I)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IEA--
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI10369126
    GO:0016936galactoside binding IEA--
    GO:0030246carbohydrate binding ----
         
    LGALS1 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lgals1):
     behavior/neurological  craniofacial  immune system  integument  mortality/aging 
     muscle  nervous system  normal  reproductive system  respiratory system 
     taste/olfaction 

    LGALS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lgals1tm1Rob for LGALS1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LGALS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LGALS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LGALS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGALS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LGALS1:
    hsa-mir-1 (MIRT023570)

    Block miRNA regulation of human, mouse, rat LGALS1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate LGALS1:
    hsa-miR-22 hsa-miR-1827
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LGALS1
    Predesigned siRNA for gene silencing in human, mouse, rat LGALS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LGALS1

    Clone
    Products:
         
    OriGene clones in human, mouse for LGALS1 (see all 6)
    OriGene ORF clones in mouse, rat for LGALS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LGALS1 (NM_002305)
    Sino Biological Human cDNA Clone for LGALS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LGALS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LGALS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LEG1_HUMAN, P09382: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005622intracellular IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169

    LGALS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LGALS1 About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31
    2Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression
    3Lymphocyte Signaling
    Lymphocyte Signaling
    4Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for LGALS1
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Lymphocyte Signaling

    1 BioSystems Pathway for LGALS1
        Validated targets of C-MYC transcriptional repression




    LGALS1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LGALS1: 
              Estrogen Receptor Signaling in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LGALS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LGALS1 (P093821, 2, 3 ENSP000002159094) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRCP085751, 2, 3, ENSP000003563464EBI-1048875,EBI-1341 MINT-8310897 MINT-8310907 I2D: score=4 STRING: ENSP00000356346
    SMN1Q166373, ENSP000003700834I2D: score=2 STRING: ENSP00000370083
    YWHAZP631042, 3, ENSP000003095034MINT-3306462 I2D: score=1 STRING: ENSP00000309503
    CD2P067293, ENSP000003584904I2D: score=4 STRING: ENSP00000358490
    GEMIN4P576783, ENSP000003217064I2D: score=4 STRING: ENSP00000321706
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002317plasma cell differentiation IEA--
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IMP12761501
    GO:0010812negative regulation of cell-substrate adhesion IEA--
    GO:0010977negative regulation of neuron projection development IEA--

    LGALS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LGALS1 (LEG1)

    4 DrugBank Compounds for LGALS1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Dithiothreitol-- --target--17139284 17016423 10592235
    Thiodigalactoside-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--10592235
    Beta-Mercaptoethanol-- 60-24-2target--10592235

    Selected Novoseek inferred chemical compound relationships for LGALS1 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetyllactosamine 86.3 36 18977853 (2), 16156668 (2), 19819223 (2), 12223272 (2) (see all 23)
    lactose 83.2 61 17373821 (2), 18509838 (2), 16697988 (2), 7780201 (1) (see all 49)
    4-f-glcnac 73 2 8077232 (1)
    gal(beta1-3)galnac 71.8 6 12382235 (1), 8955156 (1), 15862866 (1)
    thiodigalactoside 71.1 4 8872116 (1), 17457616 (1), 19053747 (1)
    gal 1 68 17 15236693 (2), 18662664 (1), 17670934 (1), 15910247 (1) (see all 13)
    galactose 63.7 25 17457616 (2), 18509838 (2), 2335508 (2), 11749598 (2) (see all 18)
    polysaccharide 63.6 58 18216021 (6), 12223272 (3), 16319083 (3), 19432560 (2) (see all 32)
    farnesylthiosalicylic acid 61.9 2 16113100 (1), 18637482 (1)
    swainsonine 60.5 13 15583810 (3), 15754003 (3), 16327992 (2), 16581792 (1) (see all 6)



    LGALS1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LGALS1 gene: 
    NM_002305.3  

    Unigene Cluster for LGALS1:

    Lectin, galactoside-binding, soluble, 1
    Hs.445351  [show with all ESTs]
    Unigene Representative Sequence: BF570935
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215909(uc003atn.3) ENST00000464120 ENST00000425542 ENST00000480207
    ENST00000454173 ENST00000489315 ENST00000472321
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate LGALS1:
    hsa-miR-22 hsa-miR-1827
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LGALS1
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    Clone
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    OriGene clones in human, mouse for LGALS1 (see all 6)
    OriGene ORF clones in mouse, rat for LGALS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LGALS1 (NM_002305)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS1
    Primer
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    OriGene qPCR primer pairs and template standards for LGALS1
    OriGene qSTAR qPCR primer pairs in human, mouse for LGALS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LGALS1
      QuantiTect SYBR Green Assays in human, mouse, rat LGALS1
      QuantiFast Probe-based Assays in human, mouse, rat LGALS1

    Additional mRNA sequence: 

    AB097036.1 AK312161.1 AL832117.1 BC001693.1 BC020675.1 BT006775.1 CR456511.1 EU363770.1 
    J04456.1 S44881.1 X14829.1 X15256.1 

    Selected DOTS entries (see all 27):

    DT.40271823  DT.100761016  DT.100689747  DT.120644987  DT.120645038  DT.454146  DT.100689749  DT.102840388 
    DT.97864050  DT.95367872  DT.100679458  DT.100689752  DT.95367883  DT.120644997  DT.95210732  DT.95326633 
    DT.95367892  DT.100689748  DT.120645009  DT.120645056  DT.92459643  DT.120644986  DT.120689532  DT.121039944 

    Selected AceView cDNA sequences (see all 1106):

    BC001693 AI066764 BQ938241 F29687 BG030646 BQ675475 BQ053431 BM665341 
    AI184276 BM768739 T09366 BE620353 AU105980 BM672742 BM977404 AI350213 
    AW960655 W52256 BU728029 CR601334 BQ673419 AI017291 BC020675 BQ669551 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LGALS1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                    -     -                 -                           
    SP2:                    -     -                 -                           
    SP3:                    -                       -                           
    SP4:                          -                 -                           
    SP5:                    -     -                 -     -     -               


    ECgene alternative splicing isoforms for LGALS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LGALS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCCAATA
    LGALS1 Expression
    About this image


    LGALS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    LGALS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LGALS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445351

    UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382
    Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in
    trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within
    fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in
    cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LGALS1: 
              Estrogen Receptor Signaling in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LGALS1
    OriGene qSTAR qPCR primer pairs in human, mouse for LGALS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LGALS1
    QuantiTect SYBR Green Assays in human, mouse, rat LGALS1
    QuantiFast Probe-based Assays in human, mouse, rat LGALS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LGALS1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lgals11 , 5 lectin, galactose binding, soluble 11, 5 85.93(n)1
    88.15(a)1
      15 (37.70 cM)5
    168521  NM_008495.21  NP_032521.11 
     789267255 
    chicken
    (Gallus gallus)
    Aves LGALS11 lectin, galactoside-binding, soluble, 1 60.65(n)
    56.39(a)
      404269  NM_206905.1  NP_996788.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    52(a)
    50(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    2(193529071-193533661)
    5(146455933-146467025)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004853781 galectin-1-like 57.6(n)
    51.2(a)
      100485378  XM_002934214.2  XP_002934260.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lgals2b1 lectin, galactoside-binding, soluble, 2b 59.06(n)
    49.12(a)
      393486  NM_200514.1  NP_956808.1 


    ENSEMBL Gene Tree for LGALS1 (if available)
    TreeFam Gene Tree for LGALS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LGALS1 gene
    LGALS22  
    9 SIMAP similar genes for LGALS1 using alignment to 3 protein entries:     LEG1_HUMAN (see all proteins):
    HL14    LGALS2    LGALS9    LGALS9B    LGALS9C    LGALS3
    LGALS8    LGALS7    LGALS7B

    LGALS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LGALS1 (see all 190)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130578661,2
    C--38069622(+) TGAGTG/ATAAGG 1 -- us2k14Minor allele frequency- A:0.12NA WA EA 360
    rs1441656621,2
    C--38069636(+) GCACCA/CCTCCC 1 -- us2k10--------
    rs1861366351,2
    --38069708(+) CACCCA/TCCCTC 1 -- us2k10--------
    rs1147959981,2
    F--38069820(+) ATCCCC/TGTTTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs761953991,2
    C,F--38069877(+) TCTGGA/CGCTTC 1 -- us2k11Minor allele frequency- C:0.16WA 118
    rs1136638961,2
    C,F--38070041(+) TTTTTT/AAATTG 1 -- us2k12Minor allele frequency- A:0.20CSA WA 119
    rs1395917881,2
    --38070065(+) CTCTTA/GTTGCC 1 -- us2k10--------
    rs1897674781,2
    --38070131(+) TCAAGC/TGATTC 1 -- us2k10--------
    rs1497090911,2
    --38070162(+) TAGCAA/GGGATT 1 -- us2k10--------
    rs572612681,2
    C,F--38070164(+) GCAGGG/CATTAC 1 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for LGALS1 (38071613 - 38075813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for LGALS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662670CNV Deletion23128226
    nsv915035CNV Loss21882294
    nsv829203CNV Loss20364138
    dgv4964n71CNV Loss21882294
    nsv834191CNV Loss17160897
    nsv528985CNV Loss19592680
    nsv471197CNV Loss18288195
    dgv4965n71CNV Loss21882294
    dgv1406e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LGALS1
    DNA2.0 Custom Variant and Variant Library Synthesis for LGALS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 150570    OMIM disorders: --

    Selected diseases for LGALS1 (see all 121):    
    About MalaCards
    chondroblastic osteosarcoma    benign metastasizing leiomyoma    appendicitis    newcastle disease
    fucosidosis    craniopharyngioma    hypobetalipoproteinemia    lymphosarcoma
    cholesteatoma    dry eye syndrome    middle ear cholesteatoma    abetalipoproteinemia
    leiomyoma    thyroid adenoma    galactosemia    central nervous system lymphoma
    leiomyosarcoma    sertoli cell-only syndrome    bladder transitional cell carcinoma    placental insufficiency

    3 diseases from the University of Copenhagen DISEASES database for LGALS1:
    Galactosemia     Cancer     Placental insufficiency

    LGALS1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for LGALS1 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 50.2 203 11414198 (5), 11259457 (4), 11145198 (4), 18202194 (4) (see all 99)
    tumor escape 47.7 6 19205418 (1), 17611674 (1), 16900348 (1), 17390012 (1)
    cancer 46.9 117 18288388 (4), 11259457 (3), 14758077 (3), 18081536 (3) (see all 72)
    metastasis 46.6 59 11259457 (3), 7954433 (2), 17884770 (2), 14758079 (2) (see all 46)
    trophoblastic tumor 45.6 4 16033063 (1), 15221419 (1), 16607538 (1), 19900702 (1)
    neoplastic transformation 42.6 4 11146440 (1), 11396139 (1), 14689585 (1), 10891535 (1)
    autoimmunity 39.5 13 16239398 (2), 12244068 (1), 16782561 (1), 19706602 (1) (see all 9)
    carcinoma squamous cell 37.6 18 8864733 (2), 9462711 (2), 19097359 (2), 11748478 (1) (see all 12)
    inflammation 36.9 44 14758085 (3), 18777589 (2), 17496346 (2), 19594634 (2) (see all 35)
    aggressiveness 35.8 16 15952056 (2), 10590378 (2), 11169519 (1), 20200618 (1) (see all 7)

    Genetic Association Database (GAD): LGALS1
    Human Genome Epidemiology (HuGE) Navigator: LGALS1 (5 documents)

    Export disorders for LGALS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LGALS1 gene, integrated from 10 sources (see all 813):
    (articles sorted by number of sources associating them with LGALS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic sequence and organization of two members of a human lectin gene family. (PubMed id 1988031)1, 2, 3 Gitt M.A. and Barondes S.H. (Biochemistry 1991)
    2. Presentation of galectin-1 by extracellular matrix triggers T cell death. (PubMed id 14617626)1, 2, 9 He J. and Baum L.G. (J. Biol. Chem. 2004)
    3. Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. (PubMed id 18824694)1, 2, 9 Than N.G.... Wildman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PubMed id 11146440)1, 2, 9 Tinari N....Liu F.-T. (Int. J. Cancer 2001)
    5. Human splenic galaptin: physicochemical characterization. (PubMed id 2383549)1, 2, 9 Sharma A.... Allen H.J. (Biochemistry 1990)
    6. Apoptosis of T cells mediated by galectin-1. (PubMed id 7501023)1, 2, 9 Perillo N.L.... Baum L.G. (Nature 1995)
    7. Functional and structural bases of a cysteine-less mutant as a long- lasting substitute for galectin-1. (PubMed id 18796645)1, 2, 9 Nishi N.... Nakamura T. (Glycobiology 2008)
    8. Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose. (PubMed id 19128029)1, 2, 9 Di Lella S....Alvarez R.M.S. (Biochemistry 2009)
    9. Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. (PubMed id 10764829)1, 2, 9 Fouillit M.... Caron M. (Glycobiology 2000)
    10. Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. (PubMed id 10369126)1, 2, 9 Walzel H.... Brock J. (Immunol. Lett. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3956 HGNC: 6561 AceView: LGALS1 Ensembl:ENSG00000100097 euGenes: HUgn3956
    ECgene: LGALS1 H-InvDB: LGALS1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LGALS1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00116

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LGALS1 gene:
    Search GeneIP for patents involving LGALS1

    Licensable Technologies for LGALS1 gene:
     Tufts University:  Use of Galectins to treat dry eye syndrome
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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