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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LGALS1 Gene

protein-coding GIFtS: 64
GCID: GC22P038071

lectin, galactoside-binding, soluble, 1

Explore 123 diseases affiliated with
LGALS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lectin, Galactoside-Binding, Soluble, 1¹ ²		S-Lac Lectin 1² ³
GBP¹ ²		GAL1²
Beta-Galactoside-Binding Lectin L-14-I² ³		Beta-Galactoside-Binding Protein 14kDa²
Lactose-Binding Lectin 1² ³		Gal-1³
Putative MAPK-Activating Protein PM12² ³		Galaptin³
14 KDa Laminin-Binding Protein² ³		Galectin 1²
14 KDa Lectin² ³		Galectin-1¹
HBL² ³		Gal-1³
HLBP14² ³		Galaptin³
HPL² ³		Lectin Galactoside-Binding Soluble 1³

External Ids:	HGNC: 6561¹	Entrez Gene: 3956²	Ensembl: ENSG00000100097⁷	OMIM: 150570⁵	UniProtKB: P09382³

Export aliases for LGALS1 gene to outside databases

Previous GC identifers: GC22P034686 GC22P036314 GC22P036396 GC22P021039

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LGALS1:

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix

interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382

Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array

of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase

Gene Wiki entry for LGALS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LGALS1 gene promoter:
p53 AP-1 ATF-2 MyoD YY1 HEN1 E2F E2F-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LGALS1 promoter sequence

Search SABiosciences Chromatin IP Primers for LGALS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGALS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

LGALS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P038071: view genomic region (about GC identifiers)

Start:	38,071,613 bp from pter	End:	38,075,813 bp from pter
Size:	4,201 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382 (See protein sequence)

Recommended Name: Galectin-1

Size: 135 amino acids; 14716 Da

Subunit: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via

poly-N-acetyllactosamine)

Subcellular location: Secreted, extracellular space, extracellular matrix

6/11 PDB 3D structures from and Proteopedia for LGALS1 (see all 11):

1GZW (3D)

1W6M (3D)

1W6N (3D)

1W6O (3D)

1W6P (3D)

1W6Q (3D)

Secondary accessions: B2R5E8 Q9UDK5

Explore the universe of human proteins at neXtProt for LGALS1: NX_P09382

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09382

LGALS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002296.1

ENSEMBL proteins:

ENSP00000215909 ENSP00000404414 ENSP00000388296

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for LGALS1 (Galectin-1)
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	OriGene Purified Protein: LGALS1 OriGene Protein Over-expression Lysate: LGALS1 OriGene Custom Protein Services for LGALS1
	GenScript Custom Purified and Recombinant Proteins Services for LGALS1
	Novus Biologicals LGALS1 Proteins Novus Biologicals LGALS1 Lysates
	Sino Biological Recombinant Protein for LGALS1
	ProSpec Recombinant Protein for LGALS1
	Uscn Proteins for LGALS1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IDA	--
GO:0005622	intracellular	IDA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	16130169

LGALS1 for ontologies About GeneDecksing

LGALS1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LGALS1
	R&D Systems Antibodies for LGALS1 (Galectin-1)
	Cell Signaling Technology (CST) Antibodies for LGALS1 (galectin-1)
	OriGene Antibodies: LGALS1 OriGene Custom Antibody Services for LGALS1
	GenScript Custom Superior Antibodies Services for LGALS1
	Novus Biologicals LGALS1 Antibodies
	Abcam antibodies for LGALS1
	Uscn Antibodies for LGALS1
	ThermoFisher Antibodies for LGALS1

Assay Products for LGALS1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for LGALS1 (Galectin-1) (see all)
	GenScript Custom Assay Services for LGALS1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LGALS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LGALS1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001079 Galectin_CRD

IPR013320 ConA-like_subgrp

IPR015535 Galectin_1

IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry P09382

ProtoNet protein and cluster: P09382

1 Blocks protein family: IPB001079 Galectin

UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382

Similarity: Contains 1 galectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382

Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array

of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase

Genatlas biochemistry entry for LGALS1:

lectin,galactoside-beta binding,soluble 1,autocrine negative growth factor (L14-I)

miRNA Products:		OriGene 3'-UTR Clone: LGALS1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate LGALS1:
		hsa-miR-22 hsa-miR-1827
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LGALS1 (see all 7) OriGene shRNA RFP: LGALS1 OriGene siRNA: LGALS1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LGALS1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LGALS1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LGALS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LGALS1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LGALS1 (NM_002305)
		Sino Biological Human cDNA Clone for LGALS1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LGALS1
		Search LifeMap BioReagents cell lines for LGALS1

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for LGALS1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IEA	--
GO:0004871	signal transducer activity	IMP	12761501
GO:0016936	galactoside binding	IEA	--
GO:0030395	lactose binding	IEA	--
GO:0042803	protein homodimerization activity	IEA	--

LGALS1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Lgals1^tm1Rob for LGALS1
     8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lgals1):

behavior/neurological	immune system	integument	mortality/aging	muscle
nervous system	normal	reproductive system

LGALS1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MAP Kinase Signaling

MAP Kinase Signaling

1.00

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Validated targets of C-MYC transcriptional repression

Validated targets of C-MYC transcriptional repression

1.00

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Cell Signaling Technology (CST) Pathways for LGALS1

	MAP Kinase Signaling
	Apoptosis and Autophagy
	Lymphocyte Signaling

1 BioSystems Pathway for LGALS1

Validated targets of C-MYC transcriptional repression

LGALS1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LGALS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/39 Interacting proteins for LGALS1 (P09382^{2, 3} ENSP00000215909⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPRC	P08575²^,³, ENSP00000356346⁴	MINT-8310897 MINT-8310907 I2D: score=4 STRING: ENSP00000356346
SMN1	Q16637³, ENSP00000370083⁴	I2D: score=2 STRING: ENSP00000370083
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3306462 I2D: score=1 STRING: ENSP00000309503
CD2	P06729³, ENSP00000358490⁴	I2D: score=4 STRING: ENSP00000358490
GEMIN4	P57678³, ENSP00000321706⁴	I2D: score=4 STRING: ENSP00000321706

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002317	plasma cell differentiation	IEA	--
GO:0006915	apoptotic process	TAS	1713454
GO:0007165	signal transduction	IMP	12761501
GO:0010812	negative regulation of cell-substrate adhesion	IEA	--
GO:0010977	negative regulation of neuron projection development	IEA	--

LGALS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LGALS1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LGALS1

4 DrugBank Compounds for LGALS1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1,4-Dithiothreitol	--	--	target	--	17139284 17016423 10592235
Thiodigalactoside	--	--	target	--	17139284 17016423 10592235
Alpha-D-Mannose	--	3458-28-4	target	--	10592235
Beta-Mercaptoethanol	--	60-24-2	target	--	10592235

10/59 Novoseek chemical compound relationships for LGALS1 gene (see all 59) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
n-acetyllactosamine	86.3	36	18977853 (2), 16156668 (2), 19819223 (2), 12223272 (2) (see all 23)
lactose	83.2	61	17373821 (2), 18509838 (2), 16697988 (2), 7780201 (1) (see all 49)
4-f-glcnac	73	2	8077232 (1)
gal(beta1-3)galnac	71.8	6	12382235 (1), 8955156 (1), 15862866 (1)
thiodigalactoside	71.1	4	8872116 (1), 17457616 (1), 19053747 (1)
gal 1	68	17	15236693 (2), 18662664 (1), 17670934 (1), 15910247 (1) (see all 13)
galactose	63.7	25	17457616 (2), 18509838 (2), 2335508 (2), 11749598 (2) (see all 18)
polysaccharide	63.6	58	18216021 (6), 12223272 (3), 16319083 (3), 19432560 (2) (see all 32)
farnesylthiosalicylic acid	61.9	2	16113100 (1), 18637482 (1)
swainsonine	60.5	13	15583810 (3), 15754003 (3), 16327992 (2), 16581792 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about LGALS1 / LEG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LGALS1 gene:

NM_002305.3

Unigene Cluster for LGALS1:

Lectin, galactoside-binding, soluble, 1

Hs.445351 [show with all ESTs]

Unigene Representative Sequence: BF570935

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000215909(uc003atn.3) ENST00000464120 ENST00000425542 ENST00000480207

ENST00000454173 ENST00000489315 ENST00000472321

miRNA Products:		OriGene 3'-UTR Clone: LGALS1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate LGALS1:
		hsa-miR-22 hsa-miR-1827
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LGALS1 (see all 7) OriGene shRNA RFP: LGALS1 OriGene siRNA: LGALS1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LGALS1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LGALS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LGALS1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LGALS1 (NM_002305)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LGALS1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LGALS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS1

Additional cDNA sequence:

AB097036.1 AK312161.1 AL832117.1 BC001693.1 BC020675.1 BT006775.1 CR456511.1 EU363770.1

J04456.1 S44881.1 X14829.1 X15256.1

24/27 DOTS entries (see all 27):

DT.40271823 DT.100761016 DT.100689747 DT.120644987 DT.120645038 DT.454146 DT.100689749 DT.102840388

DT.97864050 DT.95367872 DT.100679458 DT.100689752 DT.95367883 DT.120644997 DT.95210732 DT.95326633

DT.95367892 DT.100689748 DT.120645009 DT.120645056 DT.92459643 DT.120644986 DT.120689532 DT.121039944

24/1106 AceView cDNA sequences (see all 1106):

CF129005 W52256 H28400 CN485176 BM669447 AA378832 AW806489 CN483317

AI309110 AI350213 BQ674789 F31970 BQ708621 BM850476 BQ945831 CR456511

AW960655 BU689156 BM672730 BQ878680 AA380014 BC020675 AI302174 C05180

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LGALS1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b
SP1:							-		-						-
SP2:							-		-						-
SP3:							-								-
SP4:									-						-
SP5:							-		-						-		-		-

ECgene alternative splicing isoforms for LGALS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LGALS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCCAATA

About this image

LGALS1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Kidney

Kidney

Lower Urinary Tract

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LGALS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LGALS1

SOURCE GeneReport for Unigene cluster: Hs.445351

UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382

Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in

trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal

membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac,

smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells

SABiosciences Expression via Pathway-Focused PCR Arrays including LGALS1:

Estrogen Receptor Signaling in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LGALS1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LGALS1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LGALS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for LGALS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LGALS1 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lgals1^{1 , 5}	lectin, galactose binding, soluble 1^{1, 5}	85.93(n)¹ 88.15(a)¹		15 (37.70 cM)⁵ 16852¹ NM_008495.2¹ NP_032521.1¹ 78926725⁵
chicken (Gallus gallus)	Aves	LGALS1¹	lectin, galactoside-binding, soluble, 1	60.65(n) 56.39(a)		404269 NM_206905.1 NP_996788.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	52(a) 50(a) (see all 4)	possible ortholog possible ortholog (see all 4)	2(193529071-193533661) 5(146459007-146462410)
zebrafish (Danio rerio)	Actinopterygii	lgals2b⁶ lgals2a⁶ (see all 3)	lectin, galactoside-binding, soluble, 2a (see all 3)	43(a) 40(a) (see all 3)	many ↔ many many ↔ many (see all 3)	6(456975-463584) 3(29104393-29111376)

ENSEMBL Gene Tree for LGALS1 (if available)
TreeFam Gene Tree for LGALS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LGALS1 gene

LGALS2²

9 SIMAP similar genes for LGALS1 using alignment to 3 protein entries: LEG1_HUMAN (see all proteins):

HL14 LGALS2 LGALS9 LGALS9B LGALS9C LGALS3

LGALS8 LGALS7 LGALS7B

LGALS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13057866^1,2	C,	--	38069622(+)	`TGAGTG/ATAAGG`	1	--	us2k¹		4		NA WA EA	360
rs144165662^1,2		--	38069636(+)	`GCACCA/CCTCCC`	1	--	us2k¹		0	--	--	--	--
rs186136635^1,2		--	38069708(+)	`CACCCA/TCCCTC`	1	--	us2k¹		0	--	--	--	--
rs114795998^1,2	F,	--	38069820(+)	`ATCCCC/TGTTTT`	1	--	us2k¹		1		WA	118
rs76195399^1,2	C,F,	--	38069877(+)	`TCTGGA/CGCTTC`	1	--	us2k¹		1		WA	118
rs113663896^1,2		--	38070041(+)	`TTTTTT/AAATTG`	1	--	us2k¹		2		CSA WA	119
rs139591788^1,2		--	38070065(+)	`CTCTTA/GTTGCC`	1	--	us2k¹		0	--	--	--	--
rs189767478^1,2		--	38070131(+)	`TCAAGC/TGATTC`	1	--	us2k¹		0	--	--	--	--
rs149709091^1,2		--	38070162(+)	`TAGCAA/GGGATT`	1	--	us2k¹		0	--	--	--	--
rs57261268^1,2	C,	--	38070164(+)	`GCAGGG/CATTAC`	1	--	us2k¹		1		WA	2

HapMap Linkage Disequilibrium report for LGALS1 (38071613 - 38075813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LGALS1
1 CNV: 4128

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LGALS1 for disorders           About GeneDecksing

OMIM gene information: 150570    OMIM disorders: --

20/123 diseases for LGALS1 (see all 123):    About MalaCards

spinal cord injury sertoli cell-only syndrome middle ear cholesteatoma diffuse large b-cell lymphoma

central nervous system lymphoma amyotrophic lateral sclerosis b-cell lymphomas benign metastasizing leiomyoma

dry eye syndrome leydig cell tumor smooth muscle tumor anaplastic large cell lymphoma

placental abruption squamous cell carcinoma inflammatory bowel disease bladder transitional cell carcinoma

lateral sclerosis placental insufficiency transitional cell carcinoma newcastle disease

4 diseases from the University of Copenhagen DISEASES database for LGALS1:

Galactosemia Cancer Hypobetalipoproteinemia Placental insufficiency

10/97 Novoseek disease relationships for LGALS1 gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	50.2	203	11414198 (5), 11259457 (4), 11145198 (4), 18202194 (4) (see all 99)
tumor escape	47.7	6	19205418 (1), 17611674 (1), 16900348 (1), 17390012 (1)
cancer	46.9	117	18288388 (4), 11259457 (3), 14758077 (3), 18081536 (3) (see all 72)
metastasis	46.6	59	11259457 (3), 7954433 (2), 17884770 (2), 14758079 (2) (see all 46)
trophoblastic tumor	45.6	4	16033063 (1), 15221419 (1), 16607538 (1), 19900702 (1)
neoplastic transformation	42.6	4	11146440 (1), 11396139 (1), 14689585 (1), 10891535 (1)
autoimmunity	39.5	13	16239398 (2), 12244068 (1), 16782561 (1), 19706602 (1) (see all 9)
carcinoma squamous cell	37.6	18	8864733 (2), 9462711 (2), 19097359 (2), 11748478 (1) (see all 12)
inflammation	36.9	44	14758085 (3), 18777589 (2), 17496346 (2), 19594634 (2) (see all 35)
aggressiveness	35.8	16	15952056 (2), 10590378 (2), 11169519 (1), 20200618 (1) (see all 7)

Human Genome Epidemiology (HuGE) Navigator: LGALS1 (5 documents)

Export disorders for LGALS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LGALS1 gene, integrated from 9 sources (see all 779):
(articles sorted by number of sources associating them with LGALS1)

Utopia: connect your pdf to the dynamic
world of online information

Genomic sequence and organization of two members of a human lectin gene family. (PubMed id 1988031)^{1, 2, 3} Gitt M.A. and Barondes S.H. (1991)
Presentation of galectin-1 by extracellular matrix triggers T cell death. (PubMed id 14617626)^{1, 2, 9} He J. and Baum L.G. (2004)
Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. (PubMed id 18824694)^{1, 2, 9} Than N.G.... Wildman D.E. (2008)
Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PubMed id 11146440)^{1, 2, 9} Tinari N....Liu F.-T. (2001)
Human splenic galaptin: physicochemical characterization. (PubMed id 2383549)^{1, 2, 9} Sharma A.... Allen H.J. (1990)
Apoptosis of T cells mediated by galectin-1. (PubMed id 7501023)^{1, 2, 9} Perillo N.L.... Baum L.G. (1995)
Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. (PubMed id 18796645)^{1, 2, 9} Nishi N....Nakamura T. (2008)
Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose. (PubMed id 19128029)^{1, 2, 9} Di Lella S....Alvarez R.M.S. (2009)
Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. (PubMed id 10764829)^{1, 2, 9} Fouillit M.... Caron M. (2000)
Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. (PubMed id 10369126)^{1, 2, 9} Walzel H.... Brock J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3956	HGNC: 6561	AceView: LGALS1	Ensembl:ENSG00000100097	euGenes: HUgn3956
ECgene: LGALS1	H-InvDB: LGALS1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LGALS1	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00116

Intellectual Property for LGALS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LGALS1 gene:
Search GeneIP for patents involving LGALS1

Licensable Technologies for LGALS1 gene:

Tufts University:

Use of Galectins to treat dry eye syndrome

GeneCards and IP:
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LGALS1 Gene

lectin, galactoside-binding, soluble, 1

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LGALS1 (Gene Symbol)
Lectin, Galactoside-Binding, Soluble, 1
GBP
Beta-Galactoside-Binding Lectin L-14-I
Lactose-Binding Lectin 1
Putative MAPK-Activating Protein PM12
14 KDa Laminin-Binding Protein
14 KDa Lectin
HBL
HLBP14
HPL
S-Lac Lectin 1
GAL1
Beta-Galactoside-Binding Protein 14kDa
Gal-1
Galaptin
Galectin 1
Galectin-1
Gal-1
Galaptin
Lectin Galactoside-Binding Soluble 1

LUNG TUMOR
Leukemia T-Cell
TONGUE CARCINOMA
Carcinoma Basal Cell
Lymphoma T-Cell
dysplasia
Allergic Reaction
aggressiveness
COLON CARCINOMA
allergy
LUNG CARCINOMA
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Adenocarcinoma
AIDS
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MYELOMA
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prostate cancer
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BREAST CARCINOMA
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PROSTATE CARCINOMA
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chemically induced
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THYROID ADENOMA
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OVARIAN CARCINOMA
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restenosis
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THYROID CARCINOMA
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LGALS1 Gene

lectin, galactoside-binding, soluble, 1

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