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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LGALS1 Gene

protein-coding   GIFtS: 65
GCID: GC22P038071

Lectin, Galactoside-Binding, Soluble, 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lectin, Galactoside-Binding, Soluble, 11 2     S-Lac Lectin 12 3
Galectin 11 2     GAL12
Beta-Galactoside-Binding Lectin L-14-I2 3     GBP2
Lactose-Binding Lectin 12 3     Beta-Galactoside-Binding Protein 14kDa2
Putative MAPK-Activating Protein PM122 3     gal-12
14 KDa Laminin-Binding Protein2 3     galaptin2
14 KDa Lectin2 3     galectin-12
HBL2 3     Gal-13
HLBP142 3     Galaptin3
HPL2 3     Lectin Galactoside-Binding Soluble 13

External Ids:    HGNC: 65611   Entrez Gene: 39562   Ensembl: ENSG000001000977   OMIM: 1505705   UniProtKB: P093823   

Export aliases for LGALS1 gene to outside databases

Previous GC identifers: GC22P034686 GC22P036314 GC22P036396 GC22P021039


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LGALS1 Gene:
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix
interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for LGALS1 Gene: 
LGALS1 (lectin, galactoside-binding, soluble, 1) is a protein-coding gene. Diseases associated with LGALS1 include appendicitis, and newcastle disease. GO annotations related to this gene include protein homodimerization activity and glycoprotein binding. An important paralog of this gene is LGALS2.

UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382
Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide
array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of
Lyn kinase

Gene Wiki entry for LGALS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LGALS1 gene promoter:
         p53   AP-1   ATF-2   MyoD   YY1   HEN1   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLGALS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LGALS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LGALS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

LGALS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038071:  view genomic region     (about GC identifiers)

Start:
38,071,613 bp from pter      End:
38,075,813 bp from pter
Size:
4,201 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382 (See protein sequence)
Recommended Name: Galectin-1  
Size: 135 amino acids; 14716 Da
Subunit: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via
poly-N-acetyllactosamine)
Subcellular location: Secreted, extracellular space, extracellular matrix
6/11 PDB 3D structures from and Proteopedia for LGALS1 (see all 11):
1GZW (3D)        1W6M (3D)        1W6N (3D)        1W6O (3D)        1W6P (3D)        1W6Q (3D)    
Secondary accessions: B2R5E8 Q9UDK5

Explore the universe of human proteins at neXtProt for LGALS1: NX_P09382

Explore proteomics data for LGALS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09382

  • LGALS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LGALS1 Protein Expression
    REFSEQ proteins: NP_002296.1  
    ENSEMBL proteins: 
     ENSP00000215909   ENSP00000404414   ENSP00000388296  

    Human Recombinant Protein Products for LGALS1: 
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    R&D Systems Recombinant & Natural Proteins for LGALS1 (Galectin-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LGALS1
    OriGene Protein Over-expression Lysate for LGALS1
    OriGene MassSpec for LGALS1 
    OriGene Custom Protein Services for LGALS1
    GenScript Custom Purified and Recombinant Proteins Services for LGALS1
    Novus Biologicals LGALS1 Proteins
    Novus Biologicals LGALS1 Lysates
    Sino Biological Recombinant Protein for LGALS1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LGALS1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005622intracellular IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS16130169

    LGALS1 for ontologies           About GeneDecksing



    LGALS1 Antibody Products: 
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    R&D Systems Antibodies for LGALS1 (Galectin-1)
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    GenScript Custom Superior Antibodies Services for LGALS1
    Novus Biologicals LGALS1 Antibodies
    Abcam antibodies for LGALS1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for LGALS1
    LSBio Antibodies in human, mouse, rat for LGALS1 

    Assay Products for LGALS1: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for LGALS1 (Galectin-1)         (see all)
    GenScript Custom Assay Services for LGALS1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LGALS: Lectins, galactoside-binding

    4 InterPro protein domains:
     IPR001079 Galectin_CRD
     IPR013320 ConA-like_subgrp
     IPR015535 Galectin_1
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P09382

    ProtoNet protein and cluster: P09382

    1 Blocks protein domain: IPB001079 Galectin

    UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382
    Similarity: Contains 1 galectin domain


    LGALS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEG1_HUMAN, P09382
    Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide
    array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of
    Lyn kinase

         Genatlas biochemistry entry for LGALS1:
    lectin,galactoside-beta binding,soluble 1,autocrine negative growth factor (L14-I)

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IEA--
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI10369126
    GO:0016936galactoside binding IEA--
    GO:0030246carbohydrate binding ----
         
    LGALS1 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lgals1):
     behavior/neurological  craniofacial  immune system  integument  mortality/aging 
     muscle  nervous system  normal  reproductive system  respiratory system 
     taste/olfaction 

    LGALS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lgals1tm1Rob for LGALS1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LGALS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LGALS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LGALS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LGALS1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LGALS1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LGALS1:
    hsa-miR-22 hsa-miR-1827
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for LGALS1
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    Gene Editing
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    Sirion Biotech Validated adenovirus to knockdown LGALS1 (GAL1) in human, mouse 
                         Customized adenovirus for overexpression of LGALS1

    Clone
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    OriGene ORF clones in mouse, rat for LGALS1
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    GenScript: all cDNA clones in your preferred vector: LGALS1 (NM_002305)
    Sino Biological Human cDNA Clone for LGALS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS1
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                         Customized lentivirus expression plasmids for stable overexpression of LGALS1 

    Cell Line
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    Search LifeMap BioReagents cell lines for LGALS1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LGALS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression
    2MAP Kinase Signaling
    MAP Kinase Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy
    4Lymphocyte Signaling
    Lymphocyte Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for LGALS1
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Lymphocyte Signaling

    1 BioSystems Pathway for LGALS1
        Validated targets of C-MYC transcriptional repression




    LGALS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LGALS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for LGALS1 (P093822, 3 ENSP000002159094) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRCP085752, 3, ENSP000003563464MINT-8310897 MINT-8310907 I2D: score=4 STRING: ENSP00000356346
    SMN1Q166373, ENSP000003700834I2D: score=2 STRING: ENSP00000370083
    YWHAZP631042, 3, ENSP000003095034MINT-3306462 I2D: score=1 STRING: ENSP00000309503
    CD2P067293, ENSP000003584904I2D: score=4 STRING: ENSP00000358490
    GEMIN4P576783, ENSP000003217064I2D: score=4 STRING: ENSP00000321706
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002317plasma cell differentiation IEA--
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IMP12761501
    GO:0010812negative regulation of cell-substrate adhesion IEA--
    GO:0010977negative regulation of neuron projection development IEA--

    LGALS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LGALS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LGALS1 (LEG1)

    4 DrugBank Compounds for LGALS1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Dithiothreitol-- --target--17139284 17016423 10592235
    Thiodigalactoside-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--10592235
    Beta-Mercaptoethanol-- 60-24-2target--10592235

    10/59 Novoseek inferred chemical compound relationships for LGALS1 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-acetyllactosamine 86.3 36 18977853 (2), 16156668 (2), 19819223 (2), 12223272 (2) (see all 23)
    lactose 83.2 61 17373821 (2), 18509838 (2), 16697988 (2), 7780201 (1) (see all 49)
    4-f-glcnac 73 2 8077232 (1)
    gal(beta1-3)galnac 71.8 6 12382235 (1), 8955156 (1), 15862866 (1)
    thiodigalactoside 71.1 4 8872116 (1), 17457616 (1), 19053747 (1)
    gal 1 68 17 15236693 (2), 18662664 (1), 17670934 (1), 15910247 (1) (see all 13)
    galactose 63.7 25 17457616 (2), 18509838 (2), 2335508 (2), 11749598 (2) (see all 18)
    polysaccharide 63.6 58 18216021 (6), 12223272 (3), 16319083 (3), 19432560 (2) (see all 32)
    farnesylthiosalicylic acid 61.9 2 16113100 (1), 18637482 (1)
    swainsonine 60.5 13 15583810 (3), 15754003 (3), 16327992 (2), 16581792 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about LGALS1 / LEG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LGALS1 gene: 
    NM_002305.3  

    Unigene Cluster for LGALS1:

    Lectin, galactoside-binding, soluble, 1
    Hs.445351  [show with all ESTs]
    Unigene Representative Sequence: BF570935
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215909(uc003atn.3) ENST00000464120 ENST00000425542 ENST00000480207
    ENST00000454173 ENST00000489315 ENST00000472321
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LGALS1:
    hsa-miR-22 hsa-miR-1827
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LGALS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LGALS1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LGALS1

    Additional mRNA sequence: 

    AB097036.1 AK312161.1 AL832117.1 BC001693.1 BC020675.1 BT006775.1 CR456511.1 EU363770.1 
    J04456.1 S44881.1 X14829.1 X15256.1 

    24/27 DOTS entries (see all 27):

    DT.40271823  DT.100761016  DT.100689747  DT.120644987  DT.120645038  DT.454146  DT.100689749  DT.102840388 
    DT.97864050  DT.95367872  DT.100679458  DT.100689752  DT.95367883  DT.120644997  DT.95210732  DT.95326633 
    DT.95367892  DT.100689748  DT.120645009  DT.120645056  DT.92459643  DT.120644986  DT.120689532  DT.121039944 

    24/1106 AceView cDNA sequences (see all 1106):

    CA414912 BM784464 CD675421 BU737853 AW239423 BQ053195 AA778032 BE267515 
    BQ930387 AA035793 AA341419 BM667055 AA380014 AA317300 F34679 BM830231 
    AA343331 AW188024 AI017291 BM697875 CD671186 BQ669551 AI094874 BC020675 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LGALS1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                    -     -                 -                           
    SP2:                    -     -                 -                           
    SP3:                    -                       -                           
    SP4:                          -                 -                           
    SP5:                    -     -                 -     -     -               


    ECgene alternative splicing isoforms for LGALS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LGALS1 expression in normal human tissues (normalized intensities)      LGALS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCCAATA
    LGALS1 Expression
    About this image


    LGALS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 7 entries
             Ureter
             visceral organ   
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Metanephros
             visceral organ/metanephros/pelvis   
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See LGALS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LGALS1

    SOURCE GeneReport for Unigene cluster: Hs.445351

    UniProtKB/Swiss-Prot: LEG1_HUMAN, P09382
    Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in
    trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within
    fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in
    cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including LGALS1: 
              Estrogen Receptor Signaling in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LGALS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LGALS1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lgals11 , 5 lectin, galactose binding, soluble 11, 5 85.93(n)1
    88.15(a)1
      15 (37.70 cM)5
    168521  NM_008495.21  NP_032521.11 
     789267255 
    chicken
    (Gallus gallus)
    Aves LGALS11 lectin, galactoside-binding, soluble, 1 60.65(n)
    56.39(a)
      404269  NM_206905.1  NP_996788.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    52(a)
    51(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    2(193529071-193533661)
    5(146455933-146467025)
    zebrafish
    (Danio rerio)
    Actinopterygii lgals2b6
    lgals2a6
    (see all 3)
    lectin, galactoside-binding, soluble, 2a
    (see all 3)
    43(a)
    40(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    6(456975-463584)
    3(29104393-29111376)


    ENSEMBL Gene Tree for LGALS1 (if available)
    TreeFam Gene Tree for LGALS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LGALS1 gene
    LGALS22  
    9 SIMAP similar genes for LGALS1 using alignment to 3 protein entries:     LEG1_HUMAN (see all proteins):
    HL14    LGALS2    LGALS9    LGALS9B    LGALS9C    LGALS3
    LGALS8    LGALS7    LGALS7B

    LGALS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/190 SNPs in LGALS1 are shown (see all 190)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs130578661,2
    C--38069622(+) TGAGTG/ATAAGG 1 -- us2k14Minor allele frequency- A:0.12NA WA EA 360
    rs1441656621,2
    C--38069636(+) GCACCA/CCTCCC 1 -- us2k10--------
    rs1861366351,2
    --38069708(+) CACCCA/TCCCTC 1 -- us2k10--------
    rs1147959981,2
    F--38069820(+) ATCCCC/TGTTTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs761953991,2
    C,F--38069877(+) TCTGGA/CGCTTC 1 -- us2k11Minor allele frequency- C:0.16WA 118
    rs1136638961,2
    C,F--38070041(+) TTTTTT/AAATTG 1 -- us2k12Minor allele frequency- A:0.20CSA WA 119
    rs1395917881,2
    --38070065(+) CTCTTA/GTTGCC 1 -- us2k10--------
    rs1897674781,2
    --38070131(+) TCAAGC/TGATTC 1 -- us2k10--------
    rs1497090911,2
    --38070162(+) TAGCAA/GGGATT 1 -- us2k10--------
    rs572612681,2
    C,F--38070164(+) GCAGGG/CATTAC 1 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for LGALS1 (38071613 - 38075813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for LGALS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662670CNV Deletion23128226
    nsv915035CNV Loss21882294
    nsv829203CNV Loss20364138
    dgv4964n71CNV Loss21882294
    nsv834191CNV Loss17160897
    nsv528985CNV Loss19592680
    nsv471197CNV Loss18288195
    dgv4965n71CNV Loss21882294
    dgv1406e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 150570    OMIM disorders: --

    20/116 diseases for LGALS1 (see all 116):    About MalaCards
    appendicitis    newcastle disease    benign metastasizing leiomyoma    craniopharyngioma
    digestive diseases    fucosidosis    cholesteatoma    hypobetalipoproteinemia
    male breast cancer    middle ear cholesteatoma    lymphosarcoma    dry eye syndrome
    abetalipoproteinemia    bladder transitional cell carcinoma    galactosemia    thyroid adenoma
    leiomyoma    chorioamnionitis    placental insufficiency    central nervous system lymphoma

    3 diseases from the University of Copenhagen DISEASES database for LGALS1:
    Galactosemia     Cancer     Placental insufficiency

    LGALS1 for disorders           About GeneDecksing

    10/97 Novoseek inferred disease relationships for LGALS1 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 50.2 203 11414198 (5), 11259457 (4), 11145198 (4), 18202194 (4) (see all 99)
    tumor escape 47.7 6 19205418 (1), 17611674 (1), 16900348 (1), 17390012 (1)
    cancer 46.9 117 18288388 (4), 11259457 (3), 14758077 (3), 18081536 (3) (see all 72)
    metastasis 46.6 59 11259457 (3), 7954433 (2), 17884770 (2), 14758079 (2) (see all 46)
    trophoblastic tumor 45.6 4 16033063 (1), 15221419 (1), 16607538 (1), 19900702 (1)
    neoplastic transformation 42.6 4 11146440 (1), 11396139 (1), 14689585 (1), 10891535 (1)
    autoimmunity 39.5 13 16239398 (2), 12244068 (1), 16782561 (1), 19706602 (1) (see all 9)
    carcinoma squamous cell 37.6 18 8864733 (2), 9462711 (2), 19097359 (2), 11748478 (1) (see all 12)
    inflammation 36.9 44 14758085 (3), 18777589 (2), 17496346 (2), 19594634 (2) (see all 35)
    aggressiveness 35.8 16 15952056 (2), 10590378 (2), 11169519 (1), 20200618 (1) (see all 7)

    Genetic Association Database (GAD): LGALS1
    Human Genome Epidemiology (HuGE) Navigator: LGALS1 (5 documents)

    Export disorders for LGALS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LGALS1 gene, integrated from 9 sources (see all 807):
    (articles sorted by number of sources associating them with LGALS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic sequence and organization of two members of a human lectin gene family. (PubMed id 1988031)1, 2, 3 Gitt M.A. and Barondes S.H. (1991)
    2. Presentation of galectin-1 by extracellular matrix triggers T cell death. (PubMed id 14617626)1, 2, 9 He J. and Baum L.G. (2004)
    3. Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. (PubMed id 18824694)1, 2, 9 Than N.G.... Wildman D.E. (2008)
    4. Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PubMed id 11146440)1, 2, 9 Tinari N....Liu F.-T. (2001)
    5. Human splenic galaptin: physicochemical characterization. (PubMed id 2383549)1, 2, 9 Sharma A.... Allen H.J. (1990)
    6. Apoptosis of T cells mediated by galectin-1. (PubMed id 7501023)1, 2, 9 Perillo N.L.... Baum L.G. (1995)
    7. Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. (PubMed id 18796645)1, 2, 9 Nishi N....Nakamura T. (2008)
    8. Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose. (PubMed id 19128029)1, 2, 9 Di Lella S....Alvarez R.M.S. (2009)
    9. Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. (PubMed id 10764829)1, 2, 9 Fouillit M.... Caron M. (2000)
    10. Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. (PubMed id 10369126)1, 2, 9 Walzel H.... Brock J. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3956 HGNC: 6561 AceView: LGALS1 Ensembl:ENSG00000100097 euGenes: HUgn3956
    ECgene: LGALS1 H-InvDB: LGALS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LGALS1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00116

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LGALS1 gene:
    Search GeneIP for patents involving LGALS1

    Licensable Technologies for LGALS1 gene:
     Tufts University:  Use of Galectins to treat dry eye syndrome
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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