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Aliases for LGALS1 Gene

Aliases for LGALS1 Gene

  • Lectin, Galactoside-Binding, Soluble, 1 2 3
  • Beta-Galactoside-Binding Lectin L-14-I 3 4
  • Putative MAPK-Activating Protein PM12 3 4
  • 14 KDa Laminin-Binding Protein 3 4
  • Lactose-Binding Lectin 1 3 4
  • S-Lac Lectin 1 3 4
  • 14 KDa Lectin 3 4
  • Galectin 1 2 3
  • Galaptin 3 4
  • HLBP14 3 4
  • Gal-1 3 4
  • HBL 3 4
  • HPL 3 4
  • Beta-Galactoside-Binding Protein 14kDa 3
  • Lectin Galactoside-Binding Soluble 1 4
  • GAL1 3
  • GBP 3

External Ids for LGALS1 Gene

Previous GeneCards Identifiers for LGALS1 Gene

  • GC22P034686
  • GC22P036314
  • GC22P036396
  • GC22P038071
  • GC22P021039

Summaries for LGALS1 Gene

Entrez Gene Summary for LGALS1 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS1 Gene

LGALS1 (Lectin, Galactoside-Binding, Soluble, 1) is a Protein Coding gene. Diseases associated with LGALS1 include benign metastasizing leiomyoma and echolalia. Among its related pathways are NF-kappaB Signaling and MAP Kinase Signaling. GO annotations related to this gene include poly(A) RNA binding and signal transducer activity. An important paralog of this gene is LGALS2.

UniProtKB/Swiss-Prot for LGALS1 Gene

  • May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.

Gene Wiki entry for LGALS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS1 Gene

Genomics for LGALS1 Gene

Regulatory Elements for LGALS1 Gene

Genomic Location for LGALS1 Gene

Chromosome:
22
Start:
37,675,606 bp from pter
End:
37,679,806 bp from pter
Size:
4,201 bases
Orientation:
Plus strand

Genomic View for LGALS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGALS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS1 Gene

Proteins for LGALS1 Gene

  • Protein details for LGALS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09382-LEG1_HUMAN
    Recommended name:
    Galectin-1
    Protein Accession:
    P09382
    Secondary Accessions:
    • B2R5E8
    • Q9UDK5

    Protein attributes for LGALS1 Gene

    Size:
    135 amino acids
    Molecular mass:
    14716 Da
    Quaternary structure:
    • Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.

    Three dimensional structures from OCA and Proteopedia for LGALS1 Gene

neXtProt entry for LGALS1 Gene

Proteomics data for LGALS1 Gene at MOPED

Post-translational modifications for LGALS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LGALS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LGALS1 (Galectin-1)

No data available for DME Specific Peptides for LGALS1 Gene

Domains & Families for LGALS1 Gene

Gene Families for LGALS1 Gene

Protein Domains for LGALS1 Gene

Suggested Antigen Peptide Sequences for LGALS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09382

UniProtKB/Swiss-Prot:

LEG1_HUMAN :
  • Contains 1 galectin domain.
Domain:
  • Contains 1 galectin domain.
genes like me logo Genes that share domains with LGALS1: view

Function for LGALS1 Gene

Molecular function for LGALS1 Gene

GENATLAS Biochemistry:
lectin,galactoside-beta binding,soluble 1,autocrine negative growth factor (L14-I)
UniProtKB/Swiss-Prot Function:
May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.

Gene Ontology (GO) - Molecular Function for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IEA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 10369126
GO:0016936 galactoside binding --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with LGALS1: view
genes like me logo Genes that share phenotypes with LGALS1: view

Animal Models for LGALS1 Gene

MGI Knock Outs for LGALS1:

Animal Model Products

miRNA for LGALS1 Gene

miRTarBase miRNAs that target LGALS1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGALS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LGALS1 Gene

Localization for LGALS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS1 Gene COMPARTMENTS Subcellular localization image for LGALS1 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with LGALS1: view

Pathways & Interactions for LGALS1 Gene

genes like me logo Genes that share pathways with LGALS1: view

Pathways by source for LGALS1 Gene

3 Cell Signaling Technology pathways for LGALS1 Gene
1 BioSystems pathway for LGALS1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002317 plasma cell differentiation IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IMP 12761501
GO:0010812 negative regulation of cell-substrate adhesion IEA --
GO:0010977 negative regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with LGALS1: view

No data available for SIGNOR curated interactions for LGALS1 Gene

Drugs & Compounds for LGALS1 Gene

(25) Drugs for LGALS1 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1127
Heparin Approved, Investigational Pharma Antagonist 672,226
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97
Phosphatidylserine Approved Nutra 0

(37) Additional Compounds for LGALS1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
4-F-Glcnac
Agar
Agarose
butyrate
genes like me logo Genes that share compounds with LGALS1: view

Transcripts for LGALS1 Gene

Unigene Clusters for LGALS1 Gene

Lectin, galactoside-binding, soluble, 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LGALS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for LGALS1 Gene

GeneLoc Exon Structure for
LGALS1
ECgene alternative splicing isoforms for
LGALS1

Expression for LGALS1 Gene

mRNA expression in normal human tissues for LGALS1 Gene

Protein differential expression in normal tissues from HIPED for LGALS1 Gene

This gene is overexpressed in Amniocyte (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LGALS1 Gene



SOURCE GeneReport for Unigene cluster for LGALS1 Gene Hs.445351

mRNA Expression by UniProt/SwissProt for LGALS1 Gene

P09382-LEG1_HUMAN
Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
genes like me logo Genes that share expression patterns with LGALS1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for LGALS1 Gene

Orthologs for LGALS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LGALS1 35
  • 88.64 (n)
  • 86.67 (a)
LGALS1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LGALS1 35
  • 86.17 (n)
  • 82.22 (a)
-- 36
  • 81 (a)
OneToMany
LGALS1 36
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lgals1 35
  • 85.93 (n)
  • 88.15 (a)
Lgals1 16
Lgals1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LGALS1 35
  • 99.51 (n)
  • 100 (a)
LGALS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgals1 35
  • 86.17 (n)
  • 90.37 (a)
oppossum
(Monodelphis domestica)
Mammalia LGALS1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGALS1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves LGALS1 35
  • 60.65 (n)
  • 56.39 (a)
LGALS1 36
  • 56 (a)
OneToMany
LGALS1 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485378 35
  • 57.6 (n)
  • 51.2 (a)
zebrafish
(Danio rerio)
Actinopterygii lgals2b 35
  • 59.06 (n)
  • 49.12 (a)
lgals1l1 36
  • 36 (a)
OneToMany
lgals2a 36
  • 40 (a)
OneToMany
lgals2b 36
  • 43 (a)
OneToMany
Species with no ortholog for LGALS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGALS1 Gene

ENSEMBL:
Gene Tree for LGALS1 (if available)
TreeFam:
Gene Tree for LGALS1 (if available)

Paralogs for LGALS1 Gene

Paralogs for LGALS1 Gene

(9) SIMAP similar genes for LGALS1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LGALS1: view

Variants for LGALS1 Gene

Sequence variations from dbSNP and Humsavar for LGALS1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4887 -- 37,678,600(+) GCCTG(A/G)GGGAC stop-gained, reference
rs4888 -- 37,678,606(+) GGGAC(C/T)GAGCA reference, synonymous-codon
rs12251 -- 37,678,522(+) CTGTG(C/T)CTGCA reference, synonymous-codon
rs12403 -- 37,675,700(+) ACTCA(A/G)TCATG utr-variant-5-prime
rs929039 -- 37,675,504(+) AAAAC(C/T)GGCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LGALS1 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv834191 CNV Loss 17160897
dgv4964n71 CNV Loss 21882294
nsv471197 CNV Loss 18288195
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
esv2662670 CNV Deletion 23128226
nsv528985 CNV Loss 19592680

Variation tolerance for LGALS1 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LGALS1 Gene

HapMap Linkage Disequilibrium report
LGALS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LGALS1 Gene

Disorders for LGALS1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for LGALS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
benign metastasizing leiomyoma
  • benign metastasizing leiomyoma of uterus
echolalia
chronic monocytic leukemia
  • leukemia, monocytic, chronic
placenta disease
  • placenta disorder
germ cell and embryonal cancer
- elite association

Relevant External Links for LGALS1

Genetic Association Database (GAD)
LGALS1
Human Genome Epidemiology (HuGE) Navigator
LGALS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LGALS1
genes like me logo Genes that share disorders with LGALS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LGALS1 Gene

Publications for LGALS1 Gene

  1. N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death. (PMID: 19920154) Earl L.A. … Baum L.G. (J. Biol. Chem. 2010) 23 67
  2. Lectins as pattern recognition molecules: the effects of epitope density in innate immunity. (PMID: 19939826) Dam T.K. … Brewer C.F. (Glycobiology 2010) 23 67
  3. Lactose binding to galectin-1 modulates structural dynamics, increases conformational entropy, and occurs with apparent negative cooperativity. (PMID: 20184898) Nesmelova I.V. … Mayo K.H. (J. Mol. Biol. 2010) 23 67
  4. Glycan gimmickry by parasitic helminths: a strategy for modulating the host immune response? (PMID: 19748975) van Die I. … Cummings R.D. (Glycobiology 2010) 23 67
  5. Fluorescence intensity- and lifetime-based glucose sensing using an engineered high-Kd mutant of glucose/galactose-binding protein. (PMID: 19961827) Khan F. … Pickup J.C. (Anal. Biochem. 2010) 23 67

Products for LGALS1 Gene

Sources for LGALS1 Gene

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