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Aliases for LGALS1 Gene

Aliases for LGALS1 Gene

  • Lectin, Galactoside-Binding, Soluble, 1 2 3
  • Beta-Galactoside-Binding Lectin L-14-I 3 4
  • Putative MAPK-Activating Protein PM12 3 4
  • 14 KDa Laminin-Binding Protein 3 4
  • Lactose-Binding Lectin 1 3 4
  • S-Lac Lectin 1 3 4
  • 14 KDa Lectin 3 4
  • Galectin 1 2 3
  • Galaptin 3 4
  • HLBP14 3 4
  • Gal-1 3 4
  • HBL 3 4
  • HPL 3 4
  • Beta-Galactoside-Binding Protein 14kDa 3
  • Lectin Galactoside-Binding Soluble 1 4
  • Galectin-1 3
  • GAL1 3
  • GBP 3

External Ids for LGALS1 Gene

Summaries for LGALS1 Gene

Entrez Gene Summary for LGALS1 Gene

  • The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for LGALS1 Gene

LGALS1 (Lectin, Galactoside-Binding, Soluble, 1) is a Protein Coding gene. Diseases associated with LGALS1 include chondroblastic osteosarcoma and glioblastoma. Among its related pathways are MAPK targets/ Nuclear events mediated by MAP kinases and Apoptosis and Autophagy. GO annotations related to this gene include protein homodimerization activity and glycoprotein binding. An important paralog of this gene is LGALS2.

UniProtKB/Swiss-Prot for LGALS1 Gene

  • May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.

Gene Wiki entry for LGALS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LGALS1 Gene

Genomics for LGALS1 Gene

Genomic Location for LGALS1 Gene

Start:
37,675,606 bp from pter
End:
37,679,806 bp from pter
Size:
4,201 bases
Orientation:
Plus strand

Genomic View for LGALS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LGALS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LGALS1 Gene

Regulatory Elements for LGALS1 Gene

Proteins for LGALS1 Gene

  • Protein details for LGALS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09382-LEG1_HUMAN
    Recommended name:
    Galectin-1
    Protein Accession:
    P09382
    Secondary Accessions:
    • B2R5E8
    • Q9UDK5

    Protein attributes for LGALS1 Gene

    Size:
    135 amino acids
    Molecular mass:
    14716 Da
    Quaternary structure:
    • Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.

    Three dimensional structures from OCA and Proteopedia for LGALS1 Gene

neXtProt entry for LGALS1 Gene

Proteomics data for LGALS1 Gene at MOPED

Post-translational modifications for LGALS1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys29 and Lys108

Other Protein References for LGALS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LGALS1 Gene

Domains for LGALS1 Gene

Gene Families for LGALS1 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • LGALS :Lectins, galactoside-binding

Protein Domains for LGALS1 Gene

UniProtKB/Swiss-Prot:

LEG1_HUMAN
Domain:
  • Contains 1 galectin domain.:
    • P09382
genes like me logo Genes that share domains with LGALS1: view

Function for LGALS1 Gene

Molecular function for LGALS1 Gene

GENATLAS Biochemistry: lectin,galactoside-beta binding,soluble 1,autocrine negative growth factor (L14-I)
UniProtKB/Swiss-Prot Function: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.

Gene Ontology (GO) - Molecular Function for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IEA --
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 10369126
GO:0016936 galactoside binding IEA --
GO:0030246 carbohydrate binding --
genes like me logo Genes that share ontologies with LGALS1: view
genes like me logo Genes that share phenotypes with LGALS1: view

Animal Models for LGALS1 Gene

MGI Knock Outs for LGALS1:

miRNA for LGALS1 Gene

miRTarBase miRNAs that target LGALS1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LGALS1 Gene

Localization for LGALS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LGALS1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LGALS1 Gene COMPARTMENTS Subcellular localization image for LGALS1 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with LGALS1: view

Pathways for LGALS1 Gene

genes like me logo Genes that share pathways with LGALS1: view

Pathways by source for LGALS1 Gene

3 Cell Signaling Technology pathways for LGALS1 Gene
1 BioSystems pathway for LGALS1 Gene

Gene Ontology (GO) - Biological Process for LGALS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002317 plasma cell differentiation IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IMP 12761501
GO:0010812 negative regulation of cell-substrate adhesion IEA --
GO:0010977 negative regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with LGALS1: view

Compounds for LGALS1 Gene

(4) Drugbank Compounds for LGALS1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1,4-Dithiothreitol
target
Alpha-D-Mannose
3458-28-4 target
Beta-Mercaptoethanol
60-24-2 target
Thiodigalactoside
target

(59) Novoseek inferred chemical compound relationships for LGALS1 Gene

Compound -log(P) Hits PubMed IDs
n-acetyllactosamine 86.3 28
lactose 83.2 52
4-f-glcnac 73 1
gal(beta1-3)galnac 71.8 3
thiodigalactoside 71.1 3
genes like me logo Genes that share compounds with LGALS1: view

Transcripts for LGALS1 Gene

Unigene Clusters for LGALS1 Gene

Lectin, galactoside-binding, soluble, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LGALS1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for LGALS1 Gene

GeneLoc Exon Structure for
LGALS1
ECgene alternative splicing isoforms for
LGALS1

Expression for LGALS1 Gene

mRNA expression in normal human tissues for LGALS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LGALS1 Gene

SOURCE GeneReport for Unigene cluster for LGALS1 Gene Hs.445351

mRNA Expression by UniProt/SwissProt for LGALS1 Gene

P09382-LEG1_HUMAN
Tissue specificity: Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
genes like me logo Genes that share expressions with LGALS1: view

Orthologs for LGALS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LGALS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LGALS1 36
  • 99.51 (n)
  • 100 (a)
LGALS1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LGALS1 36
  • 88.64 (n)
  • 86.67 (a)
LGALS1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 81 (a)
OneToMany
LGALS1 36
  • 86.17 (n)
  • 82.22 (a)
LGALS1 37
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lgals1 36
  • 85.93 (n)
  • 88.15 (a)
Lgals1 16
Lgals1 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LGALS1 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LGALS1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lgals1 36
  • 86.17 (n)
  • 90.37 (a)
chicken
(Gallus gallus)
Aves LGALS1 36
  • 60.65 (n)
  • 56.39 (a)
LGALS1 37
  • 56 (a)
OneToMany
LGALS1 37
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 52 (a)
OneToMany
-- 37
  • 49 (a)
OneToMany
-- 37
  • 50 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485378 36
  • 57.6 (n)
  • 51.2 (a)
zebrafish
(Danio rerio)
Actinopterygii lgals1l1 37
  • 36 (a)
OneToMany
lgals2a 37
  • 40 (a)
OneToMany
lgals2b 36
  • 59.06 (n)
  • 49.12 (a)
lgals2b 37
  • 43 (a)
OneToMany
Species with no ortholog for LGALS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LGALS1 Gene

ENSEMBL:
Gene Tree for LGALS1 (if available)
TreeFam:
Gene Tree for LGALS1 (if available)

Paralogs for LGALS1 Gene

Paralogs for LGALS1 Gene

Selected SIMAP similar genes for LGALS1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LGALS1: view

Variants for LGALS1 Gene

Sequence variations from dbSNP and Humsavar for LGALS1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4887 -- 37,678,600(+) GCCTG(A/G)GGGAC stop-gained, reference
rs4888 -- 37,678,606(+) GGGAC(C/T)GAGCA reference, synonymous-codon
rs12251 -- 37,678,522(+) CTGTG(C/T)CTGCA reference, synonymous-codon
rs12403 -- 37,675,700(+) ACTCA(A/G)TCATG utr-variant-5-prime
rs929039 -- 37,675,504(+) AAAAC(C/T)GGCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LGALS1 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv834191 CNV Loss 17160897
dgv4964n71 CNV Loss 21882294
nsv471197 CNV Loss 18288195
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850
esv2662670 CNV Deletion 23128226
nsv528985 CNV Loss 19592680

Relevant External Links for LGALS1 Gene

HapMap Linkage Disequilibrium report
LGALS1

Disorders for LGALS1 Gene

(3) University of Copenhagen DISEASES for LGALS1 Gene

(97) Novoseek inferred disease relationships for LGALS1 Gene

Disease -log(P) Hits PubMed IDs
tumors 50.2 157
tumor escape 47.7 4
cancer 46.9 93
metastasis 46.6 51
trophoblastic tumor 45.6 4

Relevant External Links for LGALS1

Genetic Association Database (GAD)
LGALS1
Human Genome Epidemiology (HuGE) Navigator
LGALS1
genes like me logo Genes that share disorders with LGALS1: view

No data available for UniProtKB/Swiss-Prot for LGALS1 Gene

Publications for LGALS1 Gene

  1. Human splenic galaptin: physicochemical characterization. (PMID: 2383549) Sharma A. … Allen H.J. (Biochemistry 1990) 3 4 23
  2. Apoptosis of T cells mediated by galectin-1. (PMID: 7501023) Perillo N.L. … Baum L.G. (Nature 1995) 3 4 23
  3. Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. (PMID: 10764829) Fouillit M. … Caron M. (Glycobiology 2000) 3 4 23
  4. Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation. (PMID: 11146440) Tinari N. … Liu F.-T. (Int. J. Cancer 2001) 3 4 23
  5. Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. (PMID: 10369126) Walzel H. … Brock J. (Immunol. Lett. 1999) 3 4 23

Products for LGALS1 Gene

Sources for LGALS1 Gene

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