Aliases for LGALS1 Gene
External Ids for LGALS1 Gene
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for LGALS1 Gene
LGALS1 (Lectin, Galactoside-Binding, Soluble, 1) is a Protein Coding gene. Diseases associated with LGALS1 include chondroblastic osteosarcoma and glioblastoma. Among its related pathways are MAPK targets/ Nuclear events mediated by MAP kinases and Apoptosis and Autophagy. GO annotations related to this gene include protein homodimerization activity and glycoprotein binding. An important paralog of this gene is LGALS2.
UniProtKB/Swiss-Prot for LGALS1 Gene
May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.