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Aliases for LEXM Gene

Aliases for LEXM Gene

  • Lymphocyte Expansion Molecule 2 3 5
  • LEM 3 4
  • Chromosome 1 Open Reading Frame 177 2
  • C1orf177 3

External Ids for LEXM Gene

Previous HGNC Symbols for LEXM Gene

  • C1orf177

Summaries for LEXM Gene

GeneCards Summary for LEXM Gene

LEXM (Lymphocyte Expansion Molecule) is a Protein Coding gene. Diseases associated with LEXM include Emery-Dreifuss Muscular Dystrophy.

UniProtKB/Swiss-Prot for LEXM Gene

  • May have on role on T-cell metabolism however these data are controversial.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEXM Gene

Genomics for LEXM Gene

Regulatory Elements for LEXM Gene

Enhancers for LEXM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F054874 1.1 FANTOM5 ENCODE 24.6 +68.5 68465 0.3 PAF1 HLF HHEX MROH7 LEXM PIR36544 GC01P054854
GH01F054856 0.9 Ensembl ENCODE 18.3 +53.8 53793 7.5 MLX ZFP64 ARID4B FEZF1 DMAP1 GATA2 FOS PAF1 SP5 MXD4 ENSG00000233203 DHCR24 LEXM ENSG00000242396 TTC22 ENSG00000237453 LDLRAD1 MIR4781 TCEANC2 TMEM59
GH01F054792 0.9 Ensembl ENCODE 14.5 -8.5 -8541 9.5 HDGF ATF1 CREB3L1 ARID4B DMAP1 RAD21 YY1 ZNF143 FOS CREM LEXM PARS2 TTC4 DHCR24 ENSG00000242396 ENSG00000233203 TTC22 ENSG00000237453 PIR51709
GH01F054806 0.8 Ensembl ENCODE 14.1 +1.7 1694 1.6 CTCF KLF1 ZFHX2 REST RAD21 LEXM GC01P054809
GH01F054813 0.5 Ensembl ENCODE 9.2 +8.7 8733 3.4 FOSL1 JUND NR2F1 CEBPA NR2F6 CREM MAFK RELA LEXM GC01P054809 GC01P054854
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LEXM on UCSC Golden Path with GeneCards custom track

Genomic Location for LEXM Gene

Chromosome:
1
Start:
54,806,063 bp from pter
End:
54,842,264 bp from pter
Size:
36,202 bases
Orientation:
Plus strand

Genomic View for LEXM Gene

Genes around LEXM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEXM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEXM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEXM Gene

Proteins for LEXM Gene

  • Protein details for LEXM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCV2-LEXM_HUMAN
    Recommended name:
    Lymphocyte expansion molecule
    Protein Accession:
    Q3ZCV2
    Secondary Accessions:
    • B7WPL2
    • Q8N7Y9

    Protein attributes for LEXM Gene

    Size:
    418 amino acids
    Molecular mass:
    47609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LEXM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LEXM Gene

Post-translational modifications for LEXM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LEXM Gene

No data available for DME Specific Peptides for LEXM Gene

Domains & Families for LEXM Gene

Protein Domains for LEXM Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LEXM: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LEXM Gene

Function for LEXM Gene

Molecular function for LEXM Gene

UniProtKB/Swiss-Prot Function:
May have on role on T-cell metabolism however these data are controversial.
UniProtKB/Swiss-Prot Induction:
Up-regulated in activated CD8+ T-cells.
genes like me logo Genes that share phenotypes with LEXM: view

Animal Models for LEXM Gene

MGI Knock Outs for LEXM:
  • Lexm tm1a(KOMP)Wtsi

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LEXM Gene

Localization for LEXM Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEXM Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for LEXM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005761 mitochondrial ribosome IEA --
genes like me logo Genes that share ontologies with LEXM: view

No data available for Subcellular locations from COMPARTMENTS for LEXM Gene

Pathways & Interactions for LEXM Gene

SuperPathways for LEXM Gene

No Data Available

Interacting Proteins for LEXM Gene

Gene Ontology (GO) - Biological Process for LEXM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0035740 CD8-positive, alpha-beta T cell proliferation IDA --
GO:1903862 positive regulation of oxidative phosphorylation IEA --
genes like me logo Genes that share ontologies with LEXM: view

No data available for Pathways by source and SIGNOR curated interactions for LEXM Gene

Transcripts for LEXM Gene

mRNA/cDNA for LEXM Gene

(4) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LEXM Gene

No ASD Table

Relevant External Links for LEXM Gene

GeneLoc Exon Structure for
LEXM
ECgene alternative splicing isoforms for
LEXM

Expression for LEXM Gene

NURSA nuclear receptor signaling pathways regulating expression of LEXM Gene:

LEXM
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LEXM Gene

Orthologs for LEXM Gene

This gene was present in the common ancestor of chordates.

Orthologs for LEXM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf177 34
  • 98.88 (n)
C1orf177 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H1orf177 34
  • 85.51 (n)
C1orf177 35
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1orf177 34
  • 83.8 (n)
C1orf177 35
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC055111 34 35
  • 78.94 (n)
Lexm 16
rat
(Rattus norvegicus)
Mammalia RGD1559493 34
  • 78.64 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf177 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8H1ORF177 34
  • 54.19 (n)
C1orf177 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf177 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491026 34
  • 51.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
Species where no ortholog for LEXM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LEXM Gene

ENSEMBL:
Gene Tree for LEXM (if available)
TreeFam:
Gene Tree for LEXM (if available)

Paralogs for LEXM Gene

No data available for Paralogs for LEXM Gene

Variants for LEXM Gene

Sequence variations from dbSNP and Humsavar for LEXM Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1035815 -- 54,839,010(+) gagct(A/G)tggag intron-variant
rs10700346 -- 54,805,436(+) CCTCC(-/TCC)AAGAA upstream-variant-2KB
rs10788986 -- 54,811,757(+) AGTGG(A/T)TCTGA intron-variant
rs10788987 -- 54,821,414(+) gtgag(A/G)ggtct intron-variant
rs10788989 -- 54,839,362(+) TTTTT(A/T)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LEXM Gene

Variant ID Type Subtype PubMed ID
dgv38e212 CNV gain 25503493
esv1224986 CNV deletion 17803354
esv1945281 CNV deletion 18987734
esv23914 CNV loss 19812545
esv2421957 CNV duplication 20811451
esv2657155 CNV deletion 23128226
esv2675514 CNV deletion 23128226
esv2748352 CNV deletion 23290073
esv2748364 CNV deletion 23290073
esv2758937 CNV loss 17122850
esv3026 CNV loss 18987735
esv3562159 CNV deletion 23714750
esv3586102 CNV loss 21293372
esv6692 CNV loss 19470904
nsv1000673 CNV gain 25217958
nsv10173 CNV loss 18304495
nsv1110661 CNV insertion 24896259
nsv160901 CNV insertion 16902084
nsv441694 CNV loss 18776908
nsv461561 CNV gain 19166990
nsv514928 CNV gain 21397061
nsv546266 CNV gain 21841781
nsv546300 CNV loss 21841781
nsv817614 CNV gain 22305530
nsv829915 CNV gain 17160897
nsv958754 CNV deletion 24416366

Variation tolerance for LEXM Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.10; 98.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LEXM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LEXM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEXM Gene

Disorders for LEXM Gene

MalaCards: The human disease database

(1) MalaCards diseases for LEXM Gene - From: DISEASES

Disorder Aliases PubMed IDs
emery-dreifuss muscular dystrophy
  • edmd
- elite association - COSMIC cancer census association via MalaCards
Search LEXM in MalaCards View complete list of genes associated with diseases

Relevant External Links for LEXM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEXM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEXM
genes like me logo Genes that share disorders with LEXM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LEXM Gene

Publications for LEXM Gene

  1. T cell metabolism. The protein LEM promotes CD8a8_ T cell immunity through effects on mitochondrial respiration. (PMID: 25883318) Okoye I. … Ashton-Rickardt P.G. (Science 2015) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Editorial expression of concern. (PMID: 26657284) McNutt M. (Science 2015) 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64

Products for LEXM Gene

Sources for LEXM Gene

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