Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LEXM Gene

Aliases for LEXM Gene

  • Lymphocyte Expansion Molecule 2 3 5
  • LEM 3 4
  • Chromosome 1 Open Reading Frame 177 2
  • Uncharacterized Protein C1orf177 3
  • C1orf177 3

External Ids for LEXM Gene

Previous HGNC Symbols for LEXM Gene

  • C1orf177

Summaries for LEXM Gene

GeneCards Summary for LEXM Gene

LEXM (Lymphocyte Expansion Molecule) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LEXM Gene

  • May have on role on T-cell metabolism however these data are controversial.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEXM Gene

Genomics for LEXM Gene

Regulatory Elements for LEXM Gene

Enhancers for LEXM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LEXM on UCSC Golden Path with GeneCards custom track

Genomic Location for LEXM Gene

54,806,063 bp from pter
54,842,264 bp from pter
36,202 bases
Plus strand

Genomic View for LEXM Gene

Genes around LEXM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEXM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEXM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEXM Gene

Proteins for LEXM Gene

  • Protein details for LEXM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lymphocyte expansion molecule
    Protein Accession:
    Secondary Accessions:
    • B7WPL2
    • Q8N7Y9

    Protein attributes for LEXM Gene

    418 amino acids
    Molecular mass:
    47609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LEXM Gene


neXtProt entry for LEXM Gene

Proteomics data for LEXM Gene at MOPED

Post-translational modifications for LEXM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LEXM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LEXM Gene

Domains & Families for LEXM Gene

Protein Domains for LEXM Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LEXM: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LEXM Gene

Function for LEXM Gene

Molecular function for LEXM Gene

UniProtKB/Swiss-Prot Function:
May have on role on T-cell metabolism however these data are controversial.
UniProtKB/Swiss-Prot Induction:
Up-regulated in activated CD8+ T cells.
genes like me logo Genes that share phenotypes with LEXM: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LEXM Gene

Localization for LEXM Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEXM Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LEXM Gene

Pathways & Interactions for LEXM Gene

SuperPathways for LEXM Gene

No Data Available

Interacting Proteins for LEXM Gene

Gene Ontology (GO) - Biological Process for LEXM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035740 CD8-positive, alpha-beta T cell proliferation IEA,IDA 25883318
GO:1903862 positive regulation of oxidative phosphorylation IEA --
genes like me logo Genes that share ontologies with LEXM: view

No data available for Pathways by source and SIGNOR curated interactions for LEXM Gene

Drugs & Compounds for LEXM Gene

No Compound Related Data Available

Transcripts for LEXM Gene

mRNA/cDNA for LEXM Gene

(3) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for LEXM Gene

No ASD Table

Relevant External Links for LEXM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LEXM Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LEXM Gene

Orthologs for LEXM Gene

This gene was present in the common ancestor of chordates.

Orthologs for LEXM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C3H1orf177 35
  • 83.8 (n)
  • 79.85 (a)
C1orf177 36
  • 77 (a)
(Canis familiaris)
Mammalia C5H1orf177 35
  • 85.51 (n)
  • 81.66 (a)
C1orf177 36
  • 81 (a)
(Mus musculus)
Mammalia BC055111 35
  • 78.94 (n)
  • 72.14 (a)
Lexm 16
BC055111 36
  • 70 (a)
(Pan troglodytes)
Mammalia C1H1orf177 35
  • 98.88 (n)
  • 98.56 (a)
C1orf177 36
  • 98 (a)
(Rattus norvegicus)
Mammalia RGD1559493 35
  • 78.64 (n)
  • 73.57 (a)
(Monodelphis domestica)
Mammalia C1orf177 36
  • 45 (a)
(Gallus gallus)
Aves C8H1ORF177 35
  • 54.19 (n)
  • 44.03 (a)
C1orf177 36
  • 42 (a)
(Anolis carolinensis)
Reptilia C1orf177 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491026 35
  • 51.91 (n)
  • 44.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
-- 36
  • 31 (a)
Species with no ortholog for LEXM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LEXM Gene

Gene Tree for LEXM (if available)
Gene Tree for LEXM (if available)

Paralogs for LEXM Gene

No data available for Paralogs for LEXM Gene

Variants for LEXM Gene

Sequence variations from dbSNP and Humsavar for LEXM Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9782980 - 54,807,907(+) GCCCC(A/G/T)GCTCC reference, missense
rs600499 - 54,811,926(-) CTGAT(A/G)AGGCC reference, missense
rs141014 -- 54,833,466(-) TAGCC(A/G)CACAT intron-variant
rs591739 -- 54,823,784(-) aaaga(A/G)cgaca intron-variant
rs595682 -- 54,805,098(-) ACCCA(A/G)TGCCC upstream-variant-2KB

Variation tolerance for LEXM Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.10; 98.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for LEXM Gene

Disorders for LEXM Gene

Relevant External Links for LEXM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LEXM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEXM Gene

Publications for LEXM Gene

  1. T cell metabolism. The protein LEM promotes CD8a8_ T cell immunity through effects on mitochondrial respiration. (PMID: 25883318) Okoye I. … Ashton-Rickardt P.G. (Science 2015) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LEXM Gene

Sources for LEXM Gene