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Aliases for LEUTX Gene

Aliases for LEUTX Gene

  • Leucine Twenty Homeobox 2 3 5

External Ids for LEUTX Gene

Previous GeneCards Identifiers for LEUTX Gene

  • GC19P044961
  • GC19P040267
  • GC19P036713

Summaries for LEUTX Gene

GeneCards Summary for LEUTX Gene

LEUTX (Leucine Twenty Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LEUTX Gene

Genomics for LEUTX Gene

Regulatory Elements for LEUTX Gene

Enhancers for LEUTX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F039557 1.4 FANTOM5 Ensembl ENCODE 10.3 -218.2 -218171 2.1 HDGF SIX4 IRF2 PKNOX1 SAP130 ARID4B FEZF1 GATA3 ZNF366 ZNF169 PLEKHG2 EID2B CLC DLL3 LEUTX MED29 LGALS4 RPS16 PAF1 ZFP36
GH19F039676 1.2 Ensembl ENCODE 11.2 -98.0 -98022 3.6 HDGF TBP PKNOX1 TBL1XR1 SIN3A BMI1 YY1 ZNF121 EGR1 SCRT2 LGALS17A ENSG00000268088 LEUTX FBL CLC EID2B ZNF780A LGALS16
GH19F039677 1 FANTOM5 ENCODE 11.2 -100.4 -100439 0.2 MTA2 ZBED1 JUNB TBX21 ZNF121 JUND EED IKZF1 NFE2 ETV6 LEUTX FBL CLC EID2B PLEKHG2 MED29 ZFP36 PAF1 LGALS17A LGALS16
GH19F039726 1 ENCODE 10.7 -49.4 -49410 1.5 PKNOX1 SIN3A ZNF2 GLIS2 ZNF766 ZNF143 ZNF548 SP3 YY2 TSHZ1 PSMC4 LGALS14 ENSG00000269188 LOC105372399 ENSG00000269792 ENSG00000269172 LOC100129935 EID2 LEUTX LGALS13
GH19F039813 0.9 ENCODE 11.1 +37.0 37036 1.1 ZNF493 INSM2 KLF17 FEZF1 ZEB1 ZNF138 ZNF366 SCRT2 ZNF680 ZNF280D ENSG00000205041 FBL ENSG00000269069 SNRPA NUMBL LEUTX RPS16 ITPKC TTC9B ENSG00000276445
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LEUTX on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LEUTX gene promoter:

Genomic Location for LEUTX Gene

Chromosome:
19
Start:
39,776,594 bp from pter
End:
39,786,135 bp from pter
Size:
9,542 bases
Orientation:
Plus strand

Genomic View for LEUTX Gene

Genes around LEUTX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LEUTX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LEUTX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LEUTX Gene

Proteins for LEUTX Gene

  • Protein details for LEUTX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MZ59-LEUTX_HUMAN
    Recommended name:
    Leucine-twenty homeobox
    Protein Accession:
    A8MZ59

    Protein attributes for LEUTX Gene

    Size:
    168 amino acids
    Molecular mass:
    18626 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LEUTX Gene

Post-translational modifications for LEUTX Gene

No Post-translational modifications

Other Protein References for LEUTX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LEUTX Gene

Domains & Families for LEUTX Gene

Gene Families for LEUTX Gene

Protein Domains for LEUTX Gene

Suggested Antigen Peptide Sequences for LEUTX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MZ59

UniProtKB/Swiss-Prot:

LEUTX_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with LEUTX: view

Function for LEUTX Gene

Gene Ontology (GO) - Molecular Function for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with LEUTX: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LEUTX Gene

Localization for LEUTX Gene

Subcellular locations from UniProtKB/Swiss-Prot for LEUTX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LEUTX gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with LEUTX: view

Pathways & Interactions for LEUTX Gene

SuperPathways for LEUTX Gene

No Data Available

Interacting Proteins for LEUTX Gene

Gene Ontology (GO) - Biological Process for LEUTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with LEUTX: view

No data available for Pathways by source and SIGNOR curated interactions for LEUTX Gene

Transcripts for LEUTX Gene

mRNA/cDNA for LEUTX Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LEUTX Gene

Leucine twenty homeobox:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LEUTX Gene

No ASD Table

Relevant External Links for LEUTX Gene

GeneLoc Exon Structure for
LEUTX
ECgene alternative splicing isoforms for
LEUTX

Expression for LEUTX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LEUTX Gene

NURSA nuclear receptor signaling pathways regulating expression of LEUTX Gene:

LEUTX

SOURCE GeneReport for Unigene cluster for LEUTX Gene:

Hs.451638
genes like me logo Genes that share expression patterns with LEUTX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LEUTX Gene

Orthologs for LEUTX Gene

This gene was present in the common ancestor of mammals.

Orthologs for LEUTX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LEUTX 34 35
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia LEUTX 35
  • 46 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LEUTX 35
  • 37 (a)
OneToOne
Species where no ortholog for LEUTX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LEUTX Gene

ENSEMBL:
Gene Tree for LEUTX (if available)
TreeFam:
Gene Tree for LEUTX (if available)

Paralogs for LEUTX Gene

Pseudogenes.org Pseudogenes for LEUTX Gene

genes like me logo Genes that share paralogs with LEUTX: view

No data available for Paralogs for LEUTX Gene

Variants for LEUTX Gene

Sequence variations from dbSNP and Humsavar for LEUTX Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401830 -- 39,775,790(+) AAAAA(A/C)CTCTG upstream-variant-2KB
rs10409839 -- 39,777,023(+) TTTCC(C/T)GATAT intron-variant
rs10410397 -- 39,785,683(+) CCCCC(A/C)TCCTC intron-variant
rs10426810 -- 39,775,244(+) GAATG(C/T)TAAAA upstream-variant-2KB
rs10518261 -- 39,782,176(+) CTCAT(A/G)TAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LEUTX Gene

Variant ID Type Subtype PubMed ID
nsv579511 CNV loss 21841781
esv2762040 CNV loss 21179565
esv2758760 CNV gain 17122850
dgv3529n100 CNV loss 25217958

Variation tolerance for LEUTX Gene

Gene Damage Index Score: 0.35; 7.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LEUTX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LEUTX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LEUTX Gene

Disorders for LEUTX Gene

Relevant External Links for LEUTX

Genetic Association Database (GAD)
LEUTX
Human Genome Epidemiology (HuGE) Navigator
LEUTX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LEUTX

No disorders were found for LEUTX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LEUTX Gene

Publications for LEUTX Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Classification and nomenclature of all human homeobox genes. (PMID: 17963489) Holland P.W.H. … Bruford E.A. (BMC Biol. 2007) 3 4 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for LEUTX Gene

Sources for LEUTX Gene

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