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Aliases for LETMD1 Gene

Aliases for LETMD1 Gene

  • LETM1 Domain Containing 1 2 3 5
  • Cervical Cancer 1 Proto-Oncogene Protein P40 3 4
  • Cervical Cancer Proto-Oncogene 2 Protein 3 4
  • HCCR-1 3 4
  • HCRR-2 3 4
  • Cervical Cancer 1 Protooncogene 2
  • Regulator Of TP53 3
  • 1110019O13Rik 3
  • HCCR-2 3
  • HCCR1 3

External Ids for LETMD1 Gene

Previous GeneCards Identifiers for LETMD1 Gene

  • GC12P049729
  • GC12P051442
  • GC12P048474

Summaries for LETMD1 Gene

Entrez Gene Summary for LETMD1 Gene

  • This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for LETMD1 Gene

LETMD1 (LETM1 Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LETMD1 Gene

  • Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.

Gene Wiki entry for LETMD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LETMD1 Gene

Genomics for LETMD1 Gene

Regulatory Elements for LETMD1 Gene

Promoters for LETMD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LETMD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LETMD1 Gene

Chromosome:
12
Start:
51,047,962 bp from pter
End:
51,067,369 bp from pter
Size:
19,408 bases
Orientation:
Plus strand

Genomic View for LETMD1 Gene

Genes around LETMD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LETMD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LETMD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LETMD1 Gene

Proteins for LETMD1 Gene

  • Protein details for LETMD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1Q0-LTMD1_HUMAN
    Recommended name:
    LETM1 domain-containing protein 1
    Protein Accession:
    Q6P1Q0
    Secondary Accessions:
    • A6NER7
    • B3KXK7
    • Q6X2E4
    • Q6X2E5
    • Q7L2G9
    • Q7L690
    • Q8WXW6
    • Q96PK7
    • Q9BY59
    • Q9Y3X3

    Protein attributes for LETMD1 Gene

    Size:
    360 amino acids
    Molecular mass:
    41790 Da
    Quaternary structure:
    • Interacts with BRI3BP.

    Alternative splice isoforms for LETMD1 Gene

neXtProt entry for LETMD1 Gene

Proteomics data for LETMD1 Gene at MOPED

Post-translational modifications for LETMD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for LETMD1 Gene

Domains & Families for LETMD1 Gene

Protein Domains for LETMD1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6P1Q0

UniProtKB/Swiss-Prot:

LTMD1_HUMAN :
  • Contains 1 Letm1 RBD (ribosome-binding) domain.
Domain:
  • Contains 1 Letm1 RBD (ribosome-binding) domain.
genes like me logo Genes that share domains with LETMD1: view

No data available for Gene Families for LETMD1 Gene

Function for LETMD1 Gene

Molecular function for LETMD1 Gene

UniProtKB/Swiss-Prot Function:
Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.

Animal Model Products

  • Taconic Biosciences Mouse Models for LETMD1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LETMD1 Gene

Localization for LETMD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LETMD1 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LETMD1 Gene COMPARTMENTS Subcellular localization image for LETMD1 gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LETMD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with LETMD1: view

Pathways & Interactions for LETMD1 Gene

SuperPathways for LETMD1 Gene

No Data Available

Interacting Proteins for LETMD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262055%0d%0a9606.ENSP00000368959%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000262055 Q6P1Q0-LTMD1_HUMAN for LETMD1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for LETMD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LETMD1 Gene

Drugs & Compounds for LETMD1 Gene

No Compound Related Data Available

Transcripts for LETMD1 Gene

Unigene Clusters for LETMD1 Gene

LETM1 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LETMD1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b · 8c · 8d · 8e ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - -
SP17: - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - - - - - -
SP22: - - - - -
SP23: - - - - - - - - - - - - - - - - - - - - -
SP24: - - - - - - - - - - - - - - - - - - - - -
SP25: - - - - - - - - - - - - - - - - - - - -
SP26: - - - - - - - - - - - - - - - - - - -
SP27: - - - - - - - - - - - - - - - - - - - -
SP28: - - - - - - - - - - - - - - - - -
SP29:
SP30: - - - -
SP31:
SP32:
SP33:
SP34: - - -
SP35: -
SP36: - - - - - - -

ExUns: 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h · 13i · 13j · 13k · 13l · 13m · 13n ·
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8: - - - -
SP9: - - - -
SP10:
SP11:
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19: - - - -
SP20: - - -
SP21: - - -
SP22: - - - -
SP23: - - - -
SP24: - - -
SP25: - - - - - - - -
SP26: - - -
SP27: - - - - - - - -
SP28: - - - -
SP29: - - - - - - - -
SP30:
SP31:
SP32: - - -
SP33: - - - -
SP34:
SP35:
SP36:

Relevant External Links for LETMD1 Gene

GeneLoc Exon Structure for
LETMD1
ECgene alternative splicing isoforms for
LETMD1

Expression for LETMD1 Gene

mRNA expression in normal human tissues for LETMD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LETMD1 Gene

This gene is overexpressed in Bone (22.0) and Stomach (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for LETMD1 Gene



SOURCE GeneReport for Unigene cluster for LETMD1 Gene Hs.655272

mRNA Expression by UniProt/SwissProt for LETMD1 Gene

Q6P1Q0-LTMD1_HUMAN
Tissue specificity: Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.
genes like me logo Genes that share expression patterns with LETMD1: view

Protein tissue co-expression partners for LETMD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LETMD1 Gene

Orthologs for LETMD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LETMD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LETMD1 35
  • 99.72 (n)
  • 99.72 (a)
LETMD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LETMD1 36
  • 88 (a)
OneToOne
LETMD1 35
  • 90.65 (n)
  • 88.06 (a)
dog
(Canis familiaris)
Mammalia LETMD1 35
  • 91.3 (n)
  • 87.22 (a)
LETMD1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Letmd1 36
  • 80 (a)
OneToOne
Letmd1 16
Letmd1 35
  • 84.07 (n)
  • 80 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia LETMD1 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Letmd1 35
  • 83.43 (n)
  • 79.72 (a)
lizard
(Anolis carolinensis)
Reptilia LETMD1 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12988 35
tropical clawed frog
(Silurana tropicalis)
Amphibia letmd1 35
  • 59.21 (n)
  • 54.63 (a)
Str.2051 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9816 35
zebrafish
(Danio rerio)
Actinopterygii zgc:194455 35
  • 51.85 (n)
  • 43.81 (a)
LETMD1 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005736 35
  • 43.18 (n)
  • 29.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5989 36
  • 21 (a)
OneToOne
CG5989 35
  • 39.71 (n)
  • 26.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3603 36
  • 21 (a)
OneToOne
Species with no ortholog for LETMD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LETMD1 Gene

ENSEMBL:
Gene Tree for LETMD1 (if available)
TreeFam:
Gene Tree for LETMD1 (if available)

Paralogs for LETMD1 Gene

genes like me logo Genes that share paralogs with LETMD1: view

No data available for Paralogs for LETMD1 Gene

Variants for LETMD1 Gene

Sequence variations from dbSNP and Humsavar for LETMD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12379 - 51,049,161(-) CAGGA(C/T)ATAGA intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10275 -- 51,059,899(-) ATGCA(C/G/T)GGACA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1026994 -- 51,059,891(-) ACACA(A/T)GTGCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs3759405 -- 51,048,114(-) GGGAG(C/T)GAGTT upstream-variant-2KB
rs3759406 -- 51,047,968(-) GCCTC(A/G)ACTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LETMD1 Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV Loss 18971310

Variation tolerance for LETMD1 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LETMD1 Gene

HapMap Linkage Disequilibrium report
LETMD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LETMD1 Gene

Disorders for LETMD1 Gene

Relevant External Links for LETMD1

Genetic Association Database (GAD)
LETMD1
Human Genome Epidemiology (HuGE) Navigator
LETMD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LETMD1

No disorders were found for LETMD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LETMD1 Gene

Publications for LETMD1 Gene

  1. Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. (PMID: 12879013) Ko J. … Kim J.W. (Oncogene 2003) 2 3 4 67
  2. HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis. (PMID: 18045496) Cho G.W. … Kim J.W. (BMC Cell Biol. 2007) 3 23
  3. Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes. (PMID: 12061725) Qi Z.Y. … Xie Y. (J. Neurooncol. 2002) 2 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for LETMD1 Gene

Sources for LETMD1 Gene

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