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LETM2 Gene

protein-coding   GIFtS: 41
GCID: GC08P038244

Leucine Zipper-EF-Hand Containing Transmembrane Protein...

  Search for LETM2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Zipper-EF-Hand Containing Transmembrane Protein 21 2
LETM1 And EF-Hand Domain-Containing Protein 22 3
LETM1 Domain-Containing Protein LETM2, Mitochondrial2
Leucine Zipper-EF-Hand Containing Transmembrane Protein 1-Like Protein2
Leucine Zipper-EF-Hand-Containing Transmembrane Protein 1-Like3

External Ids:    HGNC: 146481   Entrez Gene: 1379942   Ensembl: ENSG000001650467   UniProtKB: Q2VYF43   

Export aliases for LETM2 gene to outside databases

Previous GC identifers: GC08P038363 GC08P036778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LETM2 Gene:
LETM2 (leucine zipper-EF-hand containing transmembrane protein 2) is a protein-coding gene. An important paralog of this gene is LETM1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LETM2 gene promoter:
         HFH-3   Egr-1   FOXD3   XBP-1   LUN-1   Nkx2-5   GATA-1   FOXI1   PPAR-gamma1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLETM2 promoter sequence
   Search Chromatin IP Primers for LETM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LETM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.23   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p12

LETM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LETM2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038244:  view genomic region     (about GC identifiers)

Start:
38,243,725 bp from pter      End:
38,267,045 bp from pter
Size:
23,321 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LETM2_HUMAN, Q2VYF4 (See protein sequence)
Recommended Name: LETM1 domain-containing protein LETM2, mitochondrial precursor  
Size: 491 amino acids; 55921 Da
Caution: Despite its name, it does not contain any EF-hand domains
Secondary accessions: A6NMG3 Q8NCR2 Q96LL1
Alternative splicing: 4 isoforms:  Q2VYF4-1   Q2VYF4-2   Q2VYF4-3   Q2VYF4-4   

Explore the universe of human proteins at neXtProt for LETM2: NX_Q2VYF4

Explore proteomics data for LETM2 at MOPED


See LETM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (6 alternative transcripts): 
NP_001186588.1  NP_001186589.1  NP_001273716.1  NP_001273748.1  NP_001273750.1  NP_653253.1  

ENSEMBL proteins: 
 ENSP00000432080   ENSP00000429269   ENSP00000297720   ENSP00000431211   ENSP00000369291  
 ENSP00000429019   ENSP00000428765   ENSP00000428944   ENSP00000432955   ENSP00000434867  
 ENSP00000432607  

LETM2 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for LETM2
OriGene Custom MassSpec
OriGene Custom Protein Services for LETM2
GenScript Custom Purified and Recombinant Proteins Services for LETM2
Novus Biologicals LETM2 Protein
Novus Biologicals LETM2 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for LETM2

 
Search eBioscience for Proteins for LETM2 

LETM2 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
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OriGene Custom Antibody Services for LETM2
Novus Biologicals LETM2 Antibodies
Abcam antibodies for LETM2
Cloud-Clone Corp. Antibodies for LETM2
Search ThermoFisher Antibodies for LETM2
LSBio Antibodies in human, mouse, rat for LETM2

LETM2 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for LETM2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for LETM2
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for LETM2
Cloud-Clone Corp. CLIAs for LETM2
Search eBioscience for ELISAs for LETM2 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
EFHAND: EF-hand domain containing

1 InterPro protein domain:
 IPR011685 LETM1

Graphical View of Domain Structure for InterPro Entry Q2VYF4

ProtoNet protein and cluster: Q2VYF4

UniProtKB/Swiss-Prot: LETM2_HUMAN, Q2VYF4
Similarity: Contains 1 LETM1 domain


Find genes that share domains with LETM2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     2 GenomeRNAi human phenotypes for LETM2:
 G0/1 arrest  Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LETM2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LETM2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LETM2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LETM2

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat LETM2 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate LETM2:
hsa-miR-4252
SwitchGear 3'UTR luciferase reporter plasmidLETM2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for LETM2
Predesigned siRNA for gene silencing in human, mouse, rat LETM2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for LETM2

Clone
Products:
     
OriGene clones in human, mouse for LETM2 (see all 7)
OriGene ORF clones in mouse, rat for LETM2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): LETM2 (NM_001199660)
Sino Biological Human cDNA Clone for LETM2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LETM2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LETM2

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for LETM2
Browse ESI BIO Cell Lines and PureStem Progenitors for LETM2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LETM2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
LETM2_HUMAN, Q2VYF4: Mitochondrion inner membrane; Single-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005743mitochondrial inner membrane IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with LETM2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LETM2
Interactions:

    Search GeneGlobe Interaction Network for LETM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for LETM2 (Q2VYF43 ENSP000002977204) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
GABARAPL1Q9H0R83I2D: score=1 
VCLP182063I2D: score=1 
ROMO1ENSP000003382934STRING: ENSP00000338293
MINOS1ENSP000003255624STRING: ENSP00000325562
MRPL33ENSP000002961024STRING: ENSP00000296102
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LETM2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for LETM2 gene (6 alternative transcripts): 
NM_001199659.2  NM_001199660.2  NM_001286787.1  NM_001286819.1  NM_001286821.1  NM_144652.3  

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000527334 ENST00000519476(uc003xlk.3) ENST00000297720(uc003xll.2)
ENST00000524874 ENST00000379957(uc003xlm.2 uc003xln.2 uc003xlo.2)
ENST00000518883 ENST00000523983 ENST00000523268 ENST00000518121(uc011lbn.2)
ENST00000526356 ENST00000527710 ENST00000528827 ENST00000530448 ENST00000527175
ENST00000526075
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat LETM2 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate LETM2:
hsa-miR-4252
SwitchGear 3'UTR luciferase reporter plasmidLETM2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for LETM2
Predesigned siRNA for gene silencing in human, mouse, rat LETM2
Clone
Products:
     
OriGene clones in human, mouse for LETM2 (see all 7)
OriGene ORF clones in mouse, rat for LETM2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): LETM2 (NM_001199660)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LETM2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LETM2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for LETM2
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LETM2
  QuantiTect SYBR Green Assays in human, mouse, rat LETM2
  QuantiFast Probe-based Assays in human, mouse, rat LETM2

Selected AceView cDNA sequences (see all 29):

CB242043 NM_144652 BC069830 AA055247 BC024250 BM694146 AK058138 AI827560 
BI562362 BG717085 AI023774 AI480250 BI489630 BG717379 AA923591 BI561721 
BC029541 AL832241 AI274843 BX954643 AA873745 BF214759 BF362802 BU732321 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for LETM2 (see all 10)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1:              -                       -     -                 -                       -                 -                                 
SP2:              -           -           -     -     -     -     -                       -                 -                                 
SP3:                                                                                      -                 -                                 
SP4:                          -           -     -                 -                                                                           
SP5:                                                                                                        -                                 


ECgene alternative splicing isoforms for LETM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LETM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GATCCTGCCT
LETM2 Expression
About this image

LETM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LETM2 Protein Expression
    Custom PCR Arrays for LETM2
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for LETM2
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LETM2
QuantiTect SYBR Green Assays in human, mouse, rat LETM2
QuantiFast Probe-based Assays in human, mouse, rat LETM2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LETM2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for LETM2 gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Letm21 , 5 leucine zipper-EF-hand containing transmembrane protein more1, 5 80.17(n)1
79.33(a)1
  8 (14.17 cM)5
2700351  NM_173012.31  NP_766600.21 
 255784925 
chicken
(Gallus gallus)
Aves LETM21 leucine zipper-EF-hand containing transmembrane protein more 66.3(n)
63.3(a)
  426779  XM_424391.4  XP_424391.4 
lizard
(Anolis carolinensis)
Reptilia LETM26
leucine zipper-EF-hand containing transmembrane pr...
53(a)
1 ↔ 1
GL343418.1(105330-120697)
African clawed frog
(Xenopus laevis)
Amphibia Xl.307982 Xenopus laevis transcribed sequence with weak similarity more 76.45(n)    48030898 
zebrafish
(Danio rerio)
Actinopterygii Dr.264182 Transcribed sequence with weak similarity to protein more 74.48(n)    BI473477.1 
fruit fly
(Drosophila melanogaster)
Insecta Letm16
Letm1
15(a)
1 → many
2R(20397031-20402843)
worm
(Caenorhabditis elegans)
Secernentea letm-16
Protein LETM-1, isoform a (letm-1) mRNA, complete ...
20(a)
1 → many
V(13661261-13664236) WBGene00010279
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLH476
MDM386
Mitochondrial inner membrane protein exposed to th...
Mitochondrial protein, forms a complex with Mba1p ...
24(a)
22(a)
many ↔ many
many ↔ many
XVI(787961-789325) YPR125W
XV(272003-273724) YOL027C


ENSEMBL Gene Tree for LETM2 (if available)
TreeFam Gene Tree for LETM2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LETM2 gene
LETM12  
2 SIMAP similar genes for LETM2 using alignment to 8 protein entries:     LETM2_HUMAN (see all proteins):
LETM1    LETMD1

Find genes that share paralogs with LETM2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LETM2 (see all 447)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1857955931,2
--38242164(+) ATTGCC/TAAGTC 2 -- us2k10--------
rs1903428521,2
--38242437(+) GCATCA/CTTTAA 2 -- us2k10--------
rs1819801891,2
C--38242508(+) TGAAAA/TCTACA 2 -- us2k10--------
rs1498338991,2
--38242523(+) CCTTCC/TAGAGC 2 -- us2k10--------
rs1458014871,2
--38242684(+) ACTGAA/GAAGTT 3 -- us2k10--------
rs354224771,2
C,F,H--38242712(+) GATCTA/GTTTGG 3 -- us2k116Minor allele frequency- G:0.13NS EA NA 1814
rs1874731941,2
C--38242963(+) CTGGAA/GTGCAG 3 -- us2k10--------
rs1906332351,2
--38243024(+) CTCCTA/GCCTCA 3 -- us2k10--------
rs1828756931,2
--38243087(+) TTGTAC/TTTTTT 3 -- us2k10--------
rs557968241,2
C,F--38243128(+) CCAAGA/GTGTTT 3 -- us2k16Minor allele frequency- G:0.29WA NA CSA EA 247

HapMap Linkage Disequilibrium report for LETM2 (38243725 - 38267045 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for LETM2: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LETM2
DNA2.0 Custom Variant and Variant Library Synthesis for LETM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease from the University of Copenhagen DISEASES database for LETM2:
Wolf-Hirschhorn syndrome

Find genes that share disorders with LETM2           About GenesLikeMe


Export disorders for LETM2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LETM2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with LETM2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. (PubMed id 11549311)1, 3 Stec I.... den Dunnen J.T. (Genomics 2001)
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  3. Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. (PubMed id 18628306)1 Tamai S.... Oka T. (J. Cell Sci. 2008)
  4. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
  9. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 137994 HGNC: 14648 AceView: LETM2 Ensembl:ENSG00000165046 euGenes: HUgn137994
ECgene: LETM2 H-InvDB: LETM2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for LETM2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LETM2 gene:
Search GeneIP for patents involving LETM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for LETM2  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for LETM2  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for LETM2  
 OriGene qSTAR qPCR primer pairs in human, mouse for LETM2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for LETM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for LETM2   OriGene Custom Protein Services for LETM2  

 
 
 Block miRNA regulation of human, mouse, rat LETM2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LETM2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LETM2 Predesigned siRNA for gene silencing in human, mouse, rat LETM2
 QuantiFast Probe-based Assays in human, mouse, rat LETM2 QuantiTect SYBR Green Assays in human, mouse, rat LETM2
 Custom PCR Arrays for LETM2 Search Chromatin IP Primers for LETM2
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LETM2  Search GeneGlobe Interaction Network for LETM2
 Regulatory tfbs in LETM2 promoter
 GenScript Custom Purified and Recombinant Proteins Services for LETM2 GenScript cDNA clones with any tag delivered in your preferred vector for LETM2
 GenScript Custom Assay Services for LETM2 GenScript Custom overexpressing Cell Line Services for LETM2
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for LETM2
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for LETM2
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 LETM2 antibodies
 LETM2 proteins
 LETM2 lysates
 Antibodies for LETM2
 See all of Abcam's Antibodies, Kits and Proteins for LETM2
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for LETM2
 Antibodies for LETM2
 ELISAs for LETM2
 CLIAs for LETM2



 Browse ESI BIO Cell Lines and PureStem Progenitors for LETM2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LETM2
 SwitchGear 3'UTR luciferase reporter plasmids for LETM2
 SwitchGear Promoter luciferase reporter plasmids for LETM2
 Search ThermoFisher Antibodies for LETM2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LETM2
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LETM2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LETM2
 LSBio Antibodies in human, mouse, rat for LETM2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for LETM2
  Search eBioscience for proteins for LETM2
  Search eBioscience for elisas for LETM2
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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