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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LETM2 Gene

protein-coding   GIFtS: 44
GCID: GC08P038244

Leucine Zipper-EF-Hand Containing Transmembrane Protein...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine Zipper-EF-Hand Containing Transmembrane Protein 21 2
LETM1 And EF-Hand Domain-Containing Protein 22 3
LETM1 Domain-Containing Protein LETM2, Mitochondrial2
Leucine Zipper-EF-Hand Containing Transmembrane Protein 1-Like Protein2
Leucine Zipper-EF-Hand-Containing Transmembrane Protein 1-Like3

External Ids:    HGNC: 146481   Entrez Gene: 1379942   Ensembl: ENSG000001650467   UniProtKB: Q2VYF43   

Export aliases for LETM2 gene to outside databases

Previous GC identifers: GC08P038363 GC08P036778


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LETM2 Gene: 
LETM2 (leucine zipper-EF-hand containing transmembrane protein 2) is a protein-coding gene. Diseases associated with LETM2 include wolf-hirschhorn syndrome. An important paralog of this gene is LETM1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LETM2 gene promoter:
         HFH-3   Egr-1   FOXD3   XBP-1   LUN-1   Nkx2-5   GATA-1   FOXI1   PPAR-gamma1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLETM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LETM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LETM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.23   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p12

LETM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LETM2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038244:  view genomic region     (about GC identifiers)

Start:
38,243,725 bp from pter      End:
38,267,045 bp from pter
Size:
23,321 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LETM2_HUMAN, Q2VYF4 (See protein sequence)
Recommended Name: LETM1 domain-containing protein LETM2, mitochondrial precursor  
Size: 491 amino acids; 55921 Da
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein (By similarity)
Caution: Despite its name, it does not contain any EF-hand domains
Secondary accessions: A6NMG3 Q8NCR2 Q96LL1
Alternative splicing: 4 isoforms:  Q2VYF4-1   Q2VYF4-2   Q2VYF4-3   Q2VYF4-4   

Explore the universe of human proteins at neXtProt for LETM2: NX_Q2VYF4

Explore proteomics data for LETM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2VYF4

  • LETM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LETM2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186588.1  NP_001186589.1  NP_653253.1  

    ENSEMBL proteins: 
     ENSP00000432080   ENSP00000429269   ENSP00000297720   ENSP00000431211   ENSP00000369291  
     ENSP00000429019   ENSP00000428765   ENSP00000428944   ENSP00000432955   ENSP00000434867  
     ENSP00000432607  

    Human Recombinant Protein Products for LETM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LETM2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for LETM2
    GenScript Custom Purified and Recombinant Proteins Services for LETM2
    Novus Biologicals LETM2 Protein
    Novus Biologicals LETM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LETM2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--

    LETM2 for ontologies           About GeneDecksing



    LETM2 Antibody Products: 
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    Abcam antibodies for LETM2
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    LSBio Antibodies in human, mouse, rat for LETM2 

    Assay Products for LETM2: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LETM2
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    Cloud-Clone Corp. ELISAs for LETM2 
    Cloud-Clone Corp. CLIAs for LETM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    1 InterPro protein domain:
     IPR011685 LETM1

    Graphical View of Domain Structure for InterPro Entry Q2VYF4

    ProtoNet protein and cluster: Q2VYF4

    UniProtKB/Swiss-Prot: LETM2_HUMAN, Q2VYF4
    Similarity: Contains 1 LETM1 domain


    LETM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for LETM2:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LETM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LETM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LETM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LETM2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LETM2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate LETM2:
    hsa-miR-4252
    SwitchGear 3'UTR luciferase reporter plasmidLETM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LETM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LETM2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LETM2
    Sirion Biotech Customized adenovirus for overexpression of LETM2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LETM2 (see all 7)
    OriGene ORF clones in mouse, rat for LETM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LETM2 (NM_001199660)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LETM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LETM2
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                         Customized lentivirus expression plasmids for stable overexpression of LETM2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LETM2
    Search LifeMap BioReagents cell lines for LETM2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LETM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LETM2

    2 Interacting proteins for LETM2 (Q2VYF43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL1Q9H0R83I2D: score=1 
    VCLP182063I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LETM2

    Search CenterWatch for drugs/clinical trials and news about LETM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LETM2 gene (3 alternative transcripts): 
    NM_001199659.1  NM_001199660.1  NM_144652.2  

    Unigene Clusters for LETM2:

    Leucine zipper-EF-hand containing transmembrane protein 2
    Hs.696457  [show with all ESTs], Hs.734005  [show with all ESTs]
    Unigene Representative Sequences: BC069830, AL832241
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527334 ENST00000519476(uc003xlk.3) ENST00000297720(uc003xll.2)
    ENST00000524874 ENST00000379957(uc003xlm.2 uc003xln.2 uc003xlo.2)
    ENST00000518883 ENST00000523983 ENST00000523268 ENST00000518121(uc011lbn.2)
    ENST00000526356 ENST00000527710 ENST00000528827 ENST00000530448 ENST00000527175
    ENST00000526075
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LETM2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate LETM2:
    hsa-miR-4252
    SwitchGear 3'UTR luciferase reporter plasmidLETM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LETM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LETM2
    Clone
    Products:
         
    OriGene clones in human, mouse for LETM2 (see all 7)
    OriGene ORF clones in mouse, rat for LETM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LETM2 (NM_001199660)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LETM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LETM2
    Sirion Biotech Customized lentivirus for stable overexpression of LETM2 
                         Customized lentivirus expression plasmids for stable overexpression of LETM2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LETM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LETM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LETM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LETM2

    Additional mRNA sequence: 

    AK289944.1 AL832241.1 

    9 DOTS entries:

    DT.75162551  DT.100748626  DT.75140791  DT.100685923  DT.65285875  DT.120644346  DT.95204641  DT.75147280 
    DT.309856 

    24/29 AceView cDNA sequences (see all 29):

    BM694146 CB242043 BC069830 NM_144652 AK058138 AA055247 BC024250 BG717379 
    AI480250 AA923591 BI489630 BG717085 BI562362 BI561721 AI023774 AI827560 
    AL832241 BC029541 AA873745 AW189536 BU732321 AI274843 AW793211 BX954643 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for LETM2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:              -                       -     -                 -                       -                 -                                 
    SP2:              -           -           -     -     -     -     -                       -                 -                                 
    SP3:                                                                                      -                 -                                 
    SP4:                          -           -     -                 -                                                                           
    SP5:                                                                                                        -                                 


    ECgene alternative splicing isoforms for LETM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LETM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCTGCCT
    LETM2 Expression
    About this image


    See LETM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LETM2

    SOURCE GeneReport for Unigene clusters: Hs.696457 Hs.734005
        SABiosciences Custom PCR Arrays for LETM2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LETM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for LETM2 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Letm21 , 5 leucine zipper-EF-hand containing transmembrane protein more1, 5 80.68(n)1
    80.6(a)1
      8 (14.17 cM)5
    2700351  NM_173012.31  NP_766600.21 
     255784925 
    chicken
    (Gallus gallus)
    Aves LETM21 leucine zipper-EF-hand containing transmembrane protein more 67.83(n)
    66.17(a)
      426779  XM_424391.3  XP_424391.3 
    lizard
    (Anolis carolinensis)
    Reptilia LETM26
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL343418.1(105330-120697)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.307982 Xenopus laevis transcribed sequence with weak similarity more 76.45(n)    48030898 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.264182 Transcribed sequence with weak similarity to protein more 74.48(n)    BI473477.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Letm16
    Letm1
    15(a)
    1 → many
    2R(20397031-20402843)
    worm
    (Caenorhabditis elegans)
    Secernentea letm-16
    Protein LETM-1, isoform a
    19(a)
    1 → many
    V(13661259-13664236)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YLH476
    MDM386
    Mitochondrial inner membrane protein exposed to th...
    Mitochondrial protein, forms a complex with Mba1p ...
    25(a)
    21(a)
    many ↔ many
    many ↔ many
    XVI(787961-789325)
    XV(272003-273724)


    ENSEMBL Gene Tree for LETM2 (if available)
    TreeFam Gene Tree for LETM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LETM2 gene
    LETM12  
    2 SIMAP similar genes for LETM2 using alignment to 8 protein entries:     LETM2_HUMAN (see all proteins):
    LETM1    LETMD1

    LETM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/447 SNPs in LETM2 are shown (see all 447)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857955931,2
    --38242164(+) ATTGCC/TAAGTC 2 -- us2k10--------
    rs1903428521,2
    --38242437(+) GCATCA/CTTTAA 2 -- us2k10--------
    rs1819801891,2
    C--38242508(+) TGAAAA/TCTACA 2 -- us2k10--------
    rs1498338991,2
    --38242523(+) CCTTCC/TAGAGC 2 -- us2k10--------
    rs1458014871,2
    --38242684(+) ACTGAA/GAAGTT 3 -- us2k10--------
    rs354224771,2
    C,F,H--38242712(+) GATCTA/GTTTGG 3 -- us2k116Minor allele frequency- G:0.13NS EA NA 1814
    rs1874731941,2
    C--38242963(+) CTGGAA/GTGCAG 3 -- us2k10--------
    rs1906332351,2
    --38243024(+) CTCCTA/GCCTCA 3 -- us2k10--------
    rs1828756931,2
    --38243087(+) TTGTAC/TTTTTT 3 -- us2k10--------
    rs557968241,2
    C,F--38243128(+) CCAAGA/GTGTTT 3 -- us2k16Minor allele frequency- G:0.29WA NA CSA EA 247

    HapMap Linkage Disequilibrium report for LETM2 (38243725 - 38267045 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LETM2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LETM2
    DNA2.0 Custom Variant and Variant Library Synthesis for LETM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for LETM2:    About MalaCards
    wolf-hirschhorn syndrome    

    1 disease from the University of Copenhagen DISEASES database for LETM2:
    Wolf-Hirschhorn syndrome

    LETM2 for disorders           About GeneDecksing


    Export disorders for LETM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LETM2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with LETM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. (PubMed id 11549311)1, 3 Stec I.... den Dunnen J.T. (2001)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 137994 HGNC: 14648 AceView: LETM2 Ensembl:ENSG00000165046 euGenes: HUgn137994
    ECgene: LETM2 H-InvDB: LETM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LETM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LETM2 gene:
    Search GeneIP for patents involving LETM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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