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Aliases for LETM2 Gene

Aliases for LETM2 Gene

  • Leucine Zipper-EF-Hand Containing Transmembrane Protein 2 2 3
  • Leucine Zipper-EF-Hand-Containing Transmembrane Protein 1-Like 4
  • LETM1 And EF-Hand Domain-Containing Protein 2 4

External Ids for LETM2 Gene

Summaries for LETM2 Gene

GeneCards Summary for LETM2 Gene

LETM2 (Leucine Zipper-EF-Hand Containing Transmembrane Protein 2) is a Protein Coding gene. An important paralog of this gene is LETM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LETM2 Gene

Genomics for LETM2 Gene

Genomic Location for LETM2 Gene

Start:
38,382,563 bp from pter
End:
38,409,527 bp from pter
Size:
26,965 bases
Orientation:
Plus strand

Genomic View for LETM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LETM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LETM2 Gene

Regulatory Elements for LETM2 Gene

Proteins for LETM2 Gene

  • Protein details for LETM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VYF4-LETM2_HUMAN
    Recommended name:
    LETM1 domain-containing protein LETM2, mitochondrial
    Protein Accession:
    Q2VYF4
    Secondary Accessions:
    • A6NMG3
    • Q8NCR2
    • Q96LL1

    Protein attributes for LETM2 Gene

    Size:
    491 amino acids
    Molecular mass:
    55921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LETM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LETM2 Gene

Proteomics data for LETM2 Gene at MOPED

Post-translational modifications for LETM2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for LETM2 Gene

Domains for LETM2 Gene

Gene Families for LETM2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for LETM2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

LETM2_HUMAN
Domain:
  • Contains 1 LETM1 domain.:
    • Q2VYF4
genes like me logo Genes that share domains with LETM2: view

Function for LETM2 Gene

Phenotypes for LETM2 Gene

GenomeRNAi human phenotypes for LETM2:
genes like me logo Genes that share phenotypes with LETM2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LETM2 Gene

Localization for LETM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LETM2 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LETM2 Gene COMPARTMENTS Subcellular localization image for LETM2 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LETM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LETM2: view

Pathways for LETM2 Gene

SuperPathways for LETM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LETM2 Gene

None

No data available for Pathways by source for LETM2 Gene

Transcripts for LETM2 Gene

Unigene Clusters for LETM2 Gene

Leucine zipper-EF-hand containing transmembrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LETM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - - -
SP8: - -
SP9:
SP10: -

Relevant External Links for LETM2 Gene

GeneLoc Exon Structure for
LETM2
ECgene alternative splicing isoforms for
LETM2

Expression for LETM2 Gene

mRNA expression in normal human tissues for LETM2 Gene

mRNA differential expression in normal tissues according to GTEx for LETM2 Gene

This gene is overexpressed in Brain - Cerebellum (6.5), Brain - Cerebellar Hemisphere (6.4), and Testis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LETM2 Gene

SOURCE GeneReport for Unigene cluster for LETM2 Gene Hs.696457

genes like me logo Genes that share expressions with LETM2: view

Orthologs for LETM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LETM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LETM2 36
  • 99.39 (n)
  • 98.57 (a)
LETM2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LETM2 36
  • 86.47 (n)
  • 86.85 (a)
LETM2 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LETM2 36
  • 88.5 (n)
  • 86.12 (a)
LETM2 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Letm2 36
  • 80.17 (n)
  • 79.33 (a)
Letm2 16
Letm2 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LETM2 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
-- 37
  • 25 (a)
OneToMany
-- 37
  • 45 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Letm2 36
  • 79.63 (n)
  • 78.68 (a)
chicken
(Gallus gallus)
Aves LETM2 36
  • 66.3 (n)
  • 63.3 (a)
LETM2 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LETM2 37
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30798 36
tropical clawed frog
(Silurana tropicalis)
Amphibia letm2 36
  • 63.83 (n)
  • 64.48 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26418 36
letm2 36
  • 57.89 (n)
  • 56.05 (a)
letm2 37
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Letm1 37
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea letm-1 37
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDM38 37
  • 22 (a)
ManyToMany
YLH47 37
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
OneToMany
Species with no ortholog for LETM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LETM2 Gene

ENSEMBL:
Gene Tree for LETM2 (if available)
TreeFam:
Gene Tree for LETM2 (if available)

Paralogs for LETM2 Gene

Paralogs for LETM2 Gene

Selected SIMAP similar genes for LETM2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LETM2: view

Variants for LETM2 Gene

Sequence variations from dbSNP and Humsavar for LETM2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2293972 -- 38,408,677(-) AAATG(A/G)TTTTT utr-variant-3-prime, downstream-variant-500B
rs2915661 -- 38,397,502(-) ATACT(A/C)TCTTA intron-variant
rs2936720 -- 38,386,113(-) TCTCC(C/T)TCGGA upstream-variant-2KB, intron-variant, utr-variant-5-prime
rs2956727 -- 38,391,918(-) ggtca(A/G)gagtt intron-variant
rs2978081 -- 38,387,346(+) AAGCG(C/T)CCCTG intron-variant

Relevant External Links for LETM2 Gene

HapMap Linkage Disequilibrium report
LETM2

No data available for Structural Variations from Database of Genomic Variants (DGV) for LETM2 Gene

Disorders for LETM2 Gene

(1) University of Copenhagen DISEASES for LETM2 Gene

genes like me logo Genes that share disorders with LETM2: view

No data available for UniProtKB/Swiss-Prot for LETM2 Gene

Publications for LETM2 Gene

  1. WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. (PMID: 11549311) Stec I. … den Dunnen J.T. (Genomics 2001) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. (PMID: 18628306) Tamai S. … Oka T. (J. Cell Sci. 2008) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for LETM2 Gene

Sources for LETM2 Gene

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