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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LETM2 Gene

protein-coding GIFtS: 45
GCID: GC08P038244

leucine zipper-EF-hand containing transmembrane protein...

Explore 2 diseases affiliated with
LETM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucine Zipper-EF-Hand Containing Transmembrane Protein 2¹ ²
LETM1 And EF-Hand Domain-Containing Protein 2² ³
FLJ25409¹
LETM1 Domain-Containing Protein LETM2, Mitochondrial²
Leucine Zipper-EF-Hand Containing Transmembrane Protein 1-Like Protein²
Leucine Zipper-EF-Hand-Containing Transmembrane Protein 1-Like³

External Ids:	HGNC: 14648¹	Entrez Gene: 137994²	Ensembl: ENSG00000165046⁷	UniProtKB: Q2VYF4³

Export aliases for LETM2 gene to outside databases

Previous GC identifers: GC08P038363 GC08P036778

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LETM2 gene promoter:
HFH-3 Egr-1 FOXD3 XBP-1 LUN-1 Nkx2-5 GATA-1 FOXI1 PPAR-gamma1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LETM2 promoter sequence

Search SABiosciences Chromatin IP Primers for LETM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LETM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.23 Ensembl cytogenetic band: 8p11.23 HGNC cytogenetic band: 8p12

LETM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LETM2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P038244: view genomic region (about GC identifiers)

Start:	38,243,725 bp from pter	End:	38,267,045 bp from pter
Size:	23,321 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LETM2_HUMAN, Q2VYF4 (See protein sequence)

Recommended Name: LETM1 domain-containing protein LETM2, mitochondrial precursor

Size: 491 amino acids; 55921 Da

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein (By similarity)

Caution: Despite its name, it does not contain any EF-hand domains

Secondary accessions: A6NMG3 Q8NCR2 Q96LL1

Alternative splicing: 4 isoforms: Q2VYF4-1 Q2VYF4-2 Q2VYF4-3 Q2VYF4-4

Explore the universe of human proteins at neXtProt for LETM2: NX_Q2VYF4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q2VYF4

LETM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001186588.1 NP_001186589.1 NP_653253.1

ENSEMBL proteins:

ENSP00000432080 ENSP00000429269 ENSP00000297720 ENSP00000431211 ENSP00000369291

ENSP00000429019 ENSP00000428765 ENSP00000428944 ENSP00000432955 ENSP00000434867

ENSP00000432607

Human Recombinant Protein Products for LETM2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: LETM2 OriGene Custom Protein Services for LETM2
	GenScript Custom Purified and Recombinant Proteins Services for LETM2
	Novus Biologicals LETM2 Protein Novus Biologicals LETM2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LETM2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

LETM2 for ontologies About GeneDecksing

LETM2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for LETM2
	GenScript Custom Superior Antibodies Services for LETM2
	Novus Biologicals LETM2 Antibodies
	Abcam antibodies for LETM2
	Uscn Antibodies for LETM2
	Search ThermoFisher Antibodies for LETM2

Assay Products for LETM2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LETM2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LETM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LETM2 for domains About GeneDecksing

1 InterPro domain/family:

IPR011685 LETM1

Graphical View of Domain Structure for InterPro Entry Q2VYF4

ProtoNet protein and cluster: Q2VYF4

UniProtKB/Swiss-Prot: LETM2_HUMAN, Q2VYF4

Similarity: Contains 1 LETM1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
2 GenomeRNAi human phenotypes for LETM2:

G0/1 arrest

Increased G1 DNA content

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LETM2

miRNA Products:		OriGene 3'-UTR Clone: LETM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LETM2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate LETM2:
		hsa-miR-4252
		SwitchGear 3'UTR luciferase reporter plasmid: LETM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LETM2 (see all 7) OriGene shRNA RFP: LETM2 OriGene siRNA: LETM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LETM2
		Sirion Biotech Custom design and validation of potent shRNA sequences against LETM2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for LETM2
			Sirion Biotech Customized adenovirus for overexpression of LETM2 Sirion Biotech Customized adenovirus for potent knockdown of LETM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LETM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LETM2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): LETM2 (NM_001199660)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LETM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LETM2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LETM2
		Search LifeMap BioReagents cell lines for LETM2
		Sirion Biotech Customized stable knockdown cell line services for LETM2 Sirion Biotech Customized inducible knockdown cell line services for LETM2 Sirion Biotech Customized stable overexpressing cell line services for LETM2 Sirion Biotech Customized inducible overexpressing cell line services for LETM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LETM2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LETM2

2 Interacting proteins for LETM2 (Q2VYF4³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GABARAPL1	Q9H0R8³	I2D: score=1
VCL	P18206³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LETM2
Search CenterWatch for drugs/clinical trials and news about LETM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LETM2 gene (3 alternative transcripts):

NM_001199659.1 NM_001199660.1 NM_144652.2

Unigene Clusters for LETM2:

Leucine zipper-EF-hand containing transmembrane protein 2

Hs.696457 [show with all ESTs], Hs.734005 [show with all ESTs]

Unigene Representative Sequences: BC069830, AL832241

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000527334 ENST00000519476(uc003xlk.3) ENST00000297720(uc003xll.2)

ENST00000524874 ENST00000379957(uc003xlm.2 uc003xln.2 uc003xlo.2)

ENST00000518883 ENST00000523983 ENST00000523268 ENST00000518121(uc011lbn.2)

ENST00000526356 ENST00000527710 ENST00000528827 ENST00000530448 ENST00000527175

ENST00000526075

miRNA Products:		OriGene 3'-UTR Clone: LETM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LETM2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate LETM2:
		hsa-miR-4252
		SwitchGear 3'UTR luciferase reporter plasmid: LETM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LETM2 (see all 7) OriGene shRNA RFP: LETM2 OriGene siRNA: LETM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LETM2
		Sirion Biotech Custom design and validation of potent shRNA sequences against LETM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LETM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LETM2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): LETM2 (NM_001199660)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LETM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LETM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LETM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat LETM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LETM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LETM2

Additional cDNA sequence:

AK289944.1 AL832241.1

8 DOTS entries:

DT.100748626 DT.75140791 DT.75162551 DT.65285875 DT.100685923 DT.120644346 DT.95204641 DT.75147280

24/29 AceView cDNA sequences (see all 29):

BC069830 NM_144652 AK058138 BC024250 CB242043 AA055247 BM694146 AI480250

AI023774 AL832241 BI562362 BC029541 BG717085 AI827560 BI561721 BG717379

AA923591 BI489630 AA873745 AW793211 BF214759 BU732321 AI274843 BF362802

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for LETM2 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13a	·	13b	·	13c
SP1:					-								-		-						-								-						-
SP2:					-				-				-		-		-		-		-								-						-
SP3:																													-						-
SP4:									-				-		-						-
SP5:																																			-

ECgene alternative splicing isoforms for LETM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LETM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCCTGCCT

About this image

LETM2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LETM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LETM2

SOURCE GeneReport for Unigene clusters: Hs.696457 Hs.734005

SABiosciences Custom PCR Arrays for LETM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LETM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat LETM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LETM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LETM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LETM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for LETM2 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LETM2¹	leucine zipper-EF-hand containing transmembrane protein more	67.83(n) 66.17(a)		426779 XM_424391.3 XP_424391.3
lizard (Anolis carolinensis)	Reptilia	LETM2⁶	--	53(a)	1 ↔ 1	GL343418.1(107258-117287)
African clawed frog (Xenopus laevis)	Amphibia	Xl.30798²	Xenopus laevis transcribed sequence with weak similarity more	76.45(n)		48030898
zebrafish (Danio rerio)	Actinopterygii	Dr.26418²	Transcribed sequence with weak similarity to protein more	74.48(n)		BI473477.1
fruit fly (Drosophila melanogaster)	Insecta	Letm1⁶	Letm1	15(a)	1 → many	2R(20397031-20402843)
worm (Caenorhabditis elegans)	Secernentea	letm-1⁶	LETM1 (Leucine zipper, EF-hand, TransMembrane mito...	20(a)	1 → many	V(13661247-13664224)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G59820⁶ AT1G65540⁶	LETM1-like protein	18(a) 18(a)	many ↔ many many ↔ many	3(22098028-22102164) 1(24362382-24366011)
rice (Oryza sativa)	Liliopsida	-- --	calcium-binding mitochondrial protein anon-60Da, p... calcium-binding mitochondrial protein anon-60Da, p...	18(a) 18(a)	many ↔ many many ↔ many	2(23860526-23869012) 4(24661764-24668800)

ENSEMBL Gene Tree for LETM2 (if available)
TreeFam Gene Tree for LETM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LETM2 gene

LETM1²

2 SIMAP similar genes for LETM2 using alignment to 8 protein entries: LETM2_HUMAN (see all proteins):

LETM1 LETMD1

LETM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185795593^1,2		--	38242164(+)	`ATTGCC/TAAGTC`	2	--	us2k¹		0	--	--	--	--
rs190342852^1,2		--	38242437(+)	`GCATCA/CTTTAA`	2	--	us2k¹		0	--	--	--	--
rs181980189^1,2		--	38242508(+)	`TGAAAA/TCTACA`	2	--	us2k¹		0	--	--	--	--
rs149833899^1,2		--	38242523(+)	`CCTTCC/TAGAGC`	2	--	us2k¹		0	--	--	--	--
rs145801487^1,2		--	38242684(+)	`ACTGAA/GAAGTT`	3	--	us2k¹		0	--	--	--	--
rs35422477^1,2	C,F,H	--	38242712(+)	`GATCTA/GTTTGG`	3	--	us2k¹		16		NS EA NA	1814
rs187473194^1,2		--	38242963(+)	`CTGGAA/GTGCAG`	3	--	us2k¹		0	--	--	--	--
rs190633235^1,2		--	38243024(+)	`CTCCTA/GCCTCA`	3	--	us2k¹		0	--	--	--	--
rs182875693^1,2		--	38243087(+)	`TTGTAC/TTTTTT`	3	--	us2k¹		0	--	--	--	--
rs55796824^1,2	C,F	--	38243128(+)	`CCAAGA/GTGTTT`	3	--	us2k¹		6		WA NA CSA EA	247

HapMap Linkage Disequilibrium report for LETM2 (38243725 - 38267045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LETM2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LETM2

DNA2.0 Custom Variant and Variant Library Synthesis for LETM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LETM2 for disorders About GeneDecksing

2 diseases for LETM2: About MalaCards

wolf-hirschhorn syndrome malaria

1 disease from the University of Copenhagen DISEASES database for LETM2:

Wolf-Hirschhorn syndrome

Export disorders for LETM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LETM2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LETM2)

Utopia: connect your pdf to the dynamic
world of online information

WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. (PubMed id 11549311)^{1, 3} Stec I.... den Dunnen J.T. (2001)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)² Nusbaum C....Lander E.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 137994	HGNC: 14648	AceView: LETM2	Ensembl:ENSG00000165046	euGenes: HUgn137994
ECgene: LETM2	H-InvDB: LETM2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LETM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LETM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LETM2 gene:
Search GeneIP for patents involving LETM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	EMD Millipore Custom Antibody & Bulk Services
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	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for LETM2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LETM2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LETM2
	OriGene Protein Over-expression Lysate for LETM2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for LETM2		OriGene 3'-UTR Clone for LETM2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LETM2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LETM2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for LETM2		OriGene Custom Protein Services for LETM2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LETM2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LETM2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LETM2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LETM2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LETM2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LETM2

	GenScript Custom Purified and Recombinant Proteins Services for LETM2		GenScript cDNA clones with any tag delivered in your preferred vector for LETM2
	GenScript Custom Assay Services for LETM2		GenScript Custom Superior Antibodies Services for LETM2
	GenScript Custom overexpressing Cell Line Services for LETM2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in LETM2 promoter
	Search Chromatin IP Primers for LETM2
	RT² qPCR Primer Assay in human, mouse / rat LETM2
	Search GNC Networks for LETM2
	SABiosciences Custom PCR Arrays for LETM2

Search Tocris compounds for LETM2

	Browse Sino Biological Proteins and Antibodies
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	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	LETM2 antibodies
	LETM2 proteins
	LETM2 lysates

	Antibodies for LETM2
	See all of Abcam's Antibodies, Kits and Proteins for LETM2
	Custom Antibody / Protein Production Service
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	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

LETM2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for LETM2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LETM2

	SwitchGear 3'UTR luciferase reporter plasmids for LETM2
	SwitchGear Promoter luciferase reporter plasmids for LETM2

Search ThermoFisher Antibodies for LETM2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LETM2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LETM2

Sirion Biotech Customized:

	stable knockdown cell line services for LETM2
	inducible knockdown cell line services for LETM2
	design and validation of potent shRNA sequences against LETM2
	adenovirus for potent knockdown of LETM2
	adenovirus for overexpression of LETM2
	stable overexpressing cell line services for LETM2
	inducible overexpressing cell line services for LETM2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LETM2 gene at Home site.

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LETM2 Gene

leucine zipper-EF-hand containing transmembrane protein...

Aliases
for LETM2 gene

Summaries
for LETM2 gene

Genomic Views
for LETM2 gene

Proteins
for LETM2 gene

Protein Domains /
Families
for LETM2 gene

Function
for LETM2 gene

Pathways & Interactions
for LETM2 gene

Drugs & Compounds
for LETM2 gene

Transcripts
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Expression
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Orthologs
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Disorders / Diseases
for LETM2 gene

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External Searches for LETM2 gene

Genome Databases showing LETM2 gene

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Export list of displayed genes

LETM2 Gene

leucine zipper-EF-hand containing transmembrane protein...

Aliasesfor LETM2 gene

Summariesfor LETM2 gene

Genomic Viewsfor LETM2 gene

Proteinsfor LETM2 gene

Protein Domains /Familiesfor LETM2 gene

Functionfor LETM2 gene

Pathways & Interactionsfor LETM2 gene

Drugs & Compoundsfor LETM2 gene

Transcriptsfor LETM2 gene

Expression for LETM2 gene

Orthologsfor LETM2 gene

Paralogsfor LETM2 gene

Genomic Variantsfor LETM2 gene

Disorders / Diseasesfor LETM2 gene

Publicationsfor LETM2 gene

External Searches for LETM2 gene

Genome Databases showing LETM2 gene

Other Databases showing LETM2 gene

Specialized Databases showing LETM2 gene

Intellectual Propertyfor LETM2 gene

Productsfor LETM2 gene

View Random Gene

Aliases
for LETM2 gene

Summaries
for LETM2 gene

Genomic Views
for LETM2 gene

Proteins
for LETM2 gene

Protein Domains /
Families
for LETM2 gene

Function
for LETM2 gene

Pathways & Interactions
for LETM2 gene

Drugs & Compounds
for LETM2 gene

Transcripts
for LETM2 gene

Expression
for LETM2 gene

Orthologs
for LETM2 gene

Paralogs
for LETM2 gene

Genomic Variants
for LETM2 gene

Disorders / Diseases
for LETM2 gene

Publications
for LETM2 gene

Intellectual Property
for LETM2 gene

Products
for LETM2 gene