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Aliases for LETM2 Gene

Aliases for LETM2 Gene

  • Leucine Zipper And EF-Hand Containing Transmembrane Protein 2 2 3
  • Leucine Zipper-EF-Hand Containing Transmembrane Protein 2 2 5
  • Leucine Zipper-EF-Hand-Containing Transmembrane Protein 1-Like 4
  • LETM1 And EF-Hand Domain-Containing Protein 2 4

External Ids for LETM2 Gene

Previous GeneCards Identifiers for LETM2 Gene

  • GC08P038244
  • GC08P036778

Summaries for LETM2 Gene

GeneCards Summary for LETM2 Gene

LETM2 (Leucine Zipper And EF-Hand Containing Transmembrane Protein 2) is a Protein Coding gene. An important paralog of this gene is LETM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LETM2 Gene

Genomics for LETM2 Gene

Regulatory Elements for LETM2 Gene

Enhancers for LETM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LETM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LETM2 Gene

38,386,207 bp from pter
38,409,527 bp from pter
23,321 bases
Plus strand

Genomic View for LETM2 Gene

Genes around LETM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LETM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LETM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LETM2 Gene

Proteins for LETM2 Gene

  • Protein details for LETM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LETM1 domain-containing protein LETM2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NMG3
    • Q8NCR2
    • Q96LL1

    Protein attributes for LETM2 Gene

    491 amino acids
    Molecular mass:
    55921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LETM2 Gene


neXtProt entry for LETM2 Gene

Proteomics data for LETM2 Gene at MOPED

Post-translational modifications for LETM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LETM2 Gene

Domains & Families for LETM2 Gene

Gene Families for LETM2 Gene

Protein Domains for LETM2 Gene


Suggested Antigen Peptide Sequences for LETM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Letm1 RBD (ribosome-binding) domain.
  • Contains 1 Letm1 RBD (ribosome-binding) domain.
genes like me logo Genes that share domains with LETM2: view

Function for LETM2 Gene

genes like me logo Genes that share phenotypes with LETM2: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LETM2 Gene

Localization for LETM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LETM2 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LETM2 Gene COMPARTMENTS Subcellular localization image for LETM2 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LETM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with LETM2: view

Pathways & Interactions for LETM2 Gene

SuperPathways for LETM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LETM2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LETM2 Gene

Drugs & Compounds for LETM2 Gene

No Compound Related Data Available

Transcripts for LETM2 Gene

Unigene Clusters for LETM2 Gene

Leucine zipper-EF-hand containing transmembrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LETM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - - -
SP8: - -
SP10: -

Relevant External Links for LETM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LETM2 Gene

mRNA expression in normal human tissues for LETM2 Gene

mRNA differential expression in normal tissues according to GTEx for LETM2 Gene

This gene is overexpressed in Brain - Cerebellum (x6.5), Brain - Cerebellar Hemisphere (x6.4), and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for LETM2 Gene

This gene is overexpressed in Retina (48.3) and Testis (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LETM2 Gene

SOURCE GeneReport for Unigene cluster for LETM2 Gene Hs.696457

genes like me logo Genes that share expression patterns with LETM2: view

Protein tissue co-expression partners for LETM2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LETM2 Gene

Orthologs for LETM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LETM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LETM2 35
  • 86.47 (n)
  • 86.85 (a)
LETM2 36
  • 76 (a)
(Canis familiaris)
Mammalia LETM2 35
  • 88.5 (n)
  • 86.12 (a)
LETM2 36
  • 79 (a)
(Mus musculus)
Mammalia Letm2 35
  • 80.17 (n)
  • 79.33 (a)
Letm2 16
Letm2 36
  • 72 (a)
(Pan troglodytes)
Mammalia LETM2 35
  • 99.39 (n)
  • 98.57 (a)
LETM2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Letm2 35
  • 79.63 (n)
  • 78.68 (a)
(Monodelphis domestica)
Mammalia LETM2 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 25 (a)
-- 36
  • 45 (a)
(Gallus gallus)
Aves LETM2 35
  • 66.3 (n)
  • 63.3 (a)
LETM2 36
  • 52 (a)
(Anolis carolinensis)
Reptilia LETM2 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia letm2 35
  • 63.83 (n)
  • 64.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30798 35
(Danio rerio)
Actinopterygii Dr.26418 35
letm2 35
  • 57.89 (n)
  • 56.05 (a)
letm2 36
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Letm1 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea letm-1 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDM38 36
  • 22 (a)
YLH47 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for LETM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LETM2 Gene

Gene Tree for LETM2 (if available)
Gene Tree for LETM2 (if available)

Paralogs for LETM2 Gene

Paralogs for LETM2 Gene

(2) SIMAP similar genes for LETM2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LETM2: view

Variants for LETM2 Gene

Sequence variations from dbSNP and Humsavar for LETM2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2293972 -- 38,408,677(-) AAATG(A/G)TTTTT utr-variant-3-prime
rs2915661 -- 38,397,502(+) ATACT(A/C/G/T)TCTTA intron-variant
rs2936720 -- 38,386,113(-) TCTCC(C/T)TCGGA upstream-variant-2KB
rs2956727 -- 38,391,918(-) ggtca(A/G)gagtt intron-variant, upstream-variant-2KB
rs2978081 -- 38,387,346(+) AAGCG(C/T)CCCTG intron-variant, upstream-variant-2KB

Variation tolerance for LETM2 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for LETM2 Gene

Disorders for LETM2 Gene

Relevant External Links for LETM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LETM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LETM2 Gene

Publications for LETM2 Gene

  1. WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. (PMID: 11549311) Stec I. … den Dunnen J.T. (Genomics 2001) 2 3 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. (PMID: 18628306) Tamai S. … Oka T. (J. Cell Sci. 2008) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for LETM2 Gene

Sources for LETM2 Gene